Compounds > pentylenetetrazole
Page last updated: 2024-08-17

pentylenetetrazole and pilocarpine

pentylenetetrazole has been researched along with pilocarpine in 100 studies

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-19904 (4.00)18.7374
1990's5 (5.00)18.2507
2000's21 (21.00)29.6817
2010's60 (60.00)24.3611
2020's10 (10.00)2.80

Authors

AuthorsStudies
Chawla, RK; Katra, BS; Rudman, D1
Bardgett, ME; Gray, BC; Miller, JW1
Zetler, G1
van Riezen, H1
Fleming, DE; Shearer, DE; Thodes, LE; Wilson, CE1
Sowell, KL; Stringer, JL1
Baran, L; Przegaliñski, E; Siwanowicz, J1
Sharma, V; Singh, R1
Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R1
Chopde, CT; Deshmukh, VK; Kasture, VS1
Chopde, CT; Kasture, SB; Kasture, VS1
Dubé, C; Koning, E; Nehlig, A1
Tan, CY; Wainman, D; Weaver, DF1
Doretto, MC; Magalhães, LH; Moraes, MF; Scarlatelli-Lima, AV1
Carvalho, JC; Carvalho, JE; Perazzo, FF; Rehder, VL1
Cavazos, JE; Cross, DJ; Jones, SM1
Boissé, L; Heida, JG; Pittman, QJ1
Bolvig, T; Clausen, RP; Falch, E; Frølund, B; Hansen, SL; Krogsgaard-Larsen, P; Larsson, OM; Perregaard, J; Petersen, G; Sarup, A; Schousboe, A; Slough, S; Watson, WP; White, HS1
Lian, XY; Stringer, JL; Zhang, ZZ1
Barton, ME; Shannon, HE1
Gal, A; Hentschke, M; Hentschke, S; Hermans-Borgmeyer, I; Hübner, CA; Jentsch, TJ; Kurth, I; Seidenbecher, T; Wiemann, M1
Anderson, NJ; Slough, S; Watson, WP1
Liu, X; Yang, H; Yang, J; Yang, Z1
Stringer, JL; Xu, K1
Ji, YH; Jiang, LL; Shu, XQ; Weng, CC; Yang, J; Zhang, JW; Zhang, XY; Zhao, R1
Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P1
Auvin, S; Bordet, R; Bouchaert, E; Lecointe, C; Porta, N; Staels, B; Vallée, L1
Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA1
Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM1
Kalra, R; Rehni, AK; Singh, N; Singh, TG1
Besio, WG; Gale, KN; Medvedev, AV1
Civelli, O; Gohil, K; Okumura, SM; Parks, GS1
Paz, C; Retana-Márquez, S; Rubio, C; Rubio-Osornio, M; Verónica Custodio, ML1
Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA1
Cardoso, A; Carvalho, LS; Freitas-da-Costa, P; Lukoyanov, NV1
Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY1
Afrikanova, T; Clinckers, R; Crawford, AD; de Witte, PA; Esguerra, CV; Loyens, E; Massie, A; Michotte, Y; Schallier, A; Serruys, AS; Smolders, I; Vermoesen, K1
Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R1
Cao, SX; Chen, XJ; Chen, Z; Duan, S; Li, KX; Li, XM; Lu, YM; Luo, JH; Xu, ZH; Zhang, J; Zhang, JM; Zhu, JM1
Akhtari, M; Bragin, A; Frew, A; Mandelkern, M; Moats, R1
Brandt, C; Löscher, W; Rattka, M1
Duncan, M; Futamura, T; Glyn, SE; Hill, AJ; Hill, TD; Jones, NA; Mercier, MS; Stephens, GJ; Stott, CG; Whalley, BJ; Williams, CM; Yamasaki, Y1
Aiello, R; Camastra, C; Chimirri, S; Citraro, R; De Sarro, G; Donato, G; Mainardi, P; Perucca, E; Russo, E; Scicchitano, F1
Ju, JG; Li, ST; Li, XR; Lu, QC; Sun, Z; Wu, SJ; Zhou, P1
Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K1
Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Barros Viana, GS; do Vale, OC; Leal, LK; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM1
Borges, K; Shaikh, MF; Tan, KN1
Cascio, MG; Duncan, M; Hill, AJ; Hill, TD; Pertwee, RG; Romano, B; Whalley, BJ; Williams, CM1
Costa, AP; de Lima, TC; de Pieri, CH; dos Santos, AA; Duarte, FS; Duzzioni, M; Farina, M; Hoeller, AA; Leme, LR; Naime, AA; Santos, EC1
Guerra, GP; Jesse, AC; Lenz, QF; Marafiga, JR; Mello, CF; Oliveira, SM; Santos, AC; Scimonelli, TN; Temp, FR1
Le, Y; Liang, F; Wang, B; Wang, H; Zhang, S1
Jain, J; Khosa, RL; Sara, UV; Sinha, R; Stables, J1
Chen, Y; Hu, L; Hua, N; Zeng, L; Zhang, H1
Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J1
Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z1
Filipek, B; Höfner, GC; Kowalczyk, P; Kulig, K; Mucha, M; Podkowa, A; Rapacz, A; Sałat, K; Wanner, KT1
Chońska, J; Dawidowski, M; Mika, W; Turło, J1
Mahmoodi, G; Mahmoodi, S; Mohammadi-Farani, A; Nedaei, SE; Pourmotabbed, A; Pourmotabbed, T1
Kouis, P; Mikroulis, A; Psarropoulou, C1
Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F1
de Oliveira, CV; Della-Pace, ID; Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Larrick, JW; Oliveira, MS; Pereira, LM; Ribeiro, LR; Royes, LF1
Barker, PA; Buckley, SM; Gibon, J; Kaartinen, V; Séguéla, P; Unsain, N1
Medina-Ceja, L; Villalpando-Vargas, F1
Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN1
Cao, Q; Chen, G; Gu, J; Jiang, G; Mi, X; Wang, K; Wang, W; Wang, X1
Borges, K; Carrasco-Pozo, C; Tan, KN1
Chen, G; Gu, J; Li, Z; Shen, H; Wang, W; Wang, X; Zhang, Y1
De Sousa, DP; Freitas, RM; Islam, MT; Junior, AL; Machado, KC; Oliveira, GL1
Bröer, S; Löscher, W1
Brandt, C; Erker, T; Löscher, W; Schidlitzki, A; Schreppel, P; Töllner, K; Twele, F1
Löscher, W; Töllner, K; Twele, F1
Chen, G; Chen, L; Jiang, G; Li, J; Liu, J; Luo, J; Wang, J; Wang, K; Wang, W; Wang, X; Xu, Z; Zhang, X; Zhang, Y1
Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K1
Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM1
Freitas, ML; Furian, AF; Grauncke, AC; Grigoletto, J; Oliveira, CV; Oliveira, MS; Santos, AR; Souto, NS; Souza, TL1
Coelho, VR; da Silva, LL; de Souza, LP; Papke, DK; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Vieira, CG1
Chang, FC; Jou, SB; Wu, YJ; Yi, PL1
Adongo, DW; Mante, PK; Woode, E1
Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ1
Braga, RM; da Fonsêca, DV; de Almeida, RN; de Farias, IEV; de Luna Freire Pessôa, H; de Melo, CGF; de Sousa, DP; do Amaral, IPG; Filho, MRDC; Lima, EM; Salgado, PRR1
Hessel, AT; Marafiga, JR; Mello, CF; Miyazato, LG; Oliveira, MS; Pillat, MM; Ribeiro, LR; Santos, AC; Temp, FR1
Josiane Ojong, L; Jules Fifen, J; Kameni Njapdounke, JS; Kavaye Kandeda, A; Ngo Bum, E; Nkamguie Nkantchoua, GC; Sotoing Taiwe, G1
Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M1
Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A1
Ali, ES; Atanasova, M; da Conceição Machado, K; da Silva Lopes, L; de Carvalho Melo-Cavalcante, AA; de Sousa Rios, MA; Dimitrova Tchekalarova, J; Găman, AM; Găman, MA; Islam, MA; Islam, MT; Khan, IN; Luiz Gomes, A; Mishra, SK; Mubarak, MS; Paz, MFCJ; Shill, MC; Yele, S1
Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER1
Kubová, H; Mareš, P1
Aguiar, CCT; Bessa, MC; Borges, LTN; Campos, AR; Cavalcante, TMB; Chaves Filho, AJM; De Melo, JMA; Fonteles, MMF; Lopes, LB; Macêdo, D; Santos, JG; Vasconcelos, LC; Vasconcelos, SMM; Vieira Neto, AE1
Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O1
Beltran-Parrazal, L; López-Meraz, ML; Morgado-Valle, C; Velazco-Cercas, E1
Dehpour, AR; Faghir-Ghanesefat, H; Gholami, M; Meskinimood, S; Rahimi, N; Sharifzadeh, M1
Birnbaumer, L; Cozart, MA; Mu, S; Phelan, KD; Rusch, NJ; Wu, H; Zheng, F1
An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y1
Askani, M; Malhi, SM; Nisar, U; Shaheen, F; Shahid, M; Simjee, SU1
Abdel-Daim, MM; Almeer, R; Kamel, M; Najda, A; Nurzyńska-Wierdak, R; Singh, M; Singh, S; Singh, TG1
Boda, VK; Hou, R; Jiang, J; Li, L; Li, W; Nagib, MM; Wu, Z; Yasmen, N; Yu, Y; Zhang, S1
Amanlou, A; Dehpour, AR; Dejban, P; Eslami, F; Rahimi, N; Shayan, M1
Singh, S; Singh, TG1
Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB1
Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D1

Reviews

3 review(s) available for pentylenetetrazole and pilocarpine

ArticleYear
Possible therapeutic effects of transcutaneous electrical stimulation via concentric ring electrodes.
    Epilepsia, 2010, Volume: 51 Suppl 3

    Topics: Animals; Convulsants; Disease Models, Animal; Electrodes; Penicillin G; Pentylenetetrazole; Pilocarpine; Rats; Seizures; Transcutaneous Electric Nerve Stimulation

2010
In vivo experimental models of epilepsy.
    Central nervous system agents in medicinal chemistry, 2010, Dec-01, Volume: 10, Issue:4

    Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Epilepsy, Reflex; Flurothyl; gamma-Aminobutyric Acid; Humans; Kainic Acid; Kindling, Neurologic; Muscarinic Agonists; Papio; Penicillins; Pentylenetetrazole; Pilocarpine; Tetanus Toxin; Zinc Compounds

2010
The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.
    Expert reviews in molecular medicine, 2016, Mar-21, Volume: 18

    Topics: Action Potentials; Animals; Cyclic AMP Response Element-Binding Protein; Epilepsy; Gene Expression Regulation; HEK293 Cells; Hippocampus; Humans; MicroRNAs; Neurons; Pentylenetetrazole; Pilocarpine; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2016

Other Studies

97 other study(ies) available for pentylenetetrazole and pilocarpine

ArticleYear
Melanotropic activity in extrahypophyseal regions of rodent brain: effect of age, hormones, and drugs.
    The American journal of physiology, 1975, Volume: 228, Issue:4

    Topics: Acetylcholine; Age Factors; Animals; Atropine; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Chick Embryo; Cycloheximide; Dihydroxyphenylalanine; Female; Fenclonine; Hydroxydopamines; Insulin; Male; Melanocyte-Stimulating Hormones; Melatonin; Mesencephalon; Methyltyrosines; Mice; Mitochondria; Myelin Sheath; Nerve Endings; Norepinephrine; Pargyline; Pentobarbital; Pentylenetetrazole; Pilocarpine; Pituitary Gland; Rats; Reserpine; Serotonin; Sex Factors; Starvation

1975
Characterization of cholinergic regulation of seizures by the midline thalamus.
    Neuropharmacology, 1992, Volume: 31, Issue:4

    Topics: Animals; Female; Neostigmine; Nicotine; Parasympathomimetics; Pentylenetetrazole; Pilocarpine; Rats; Rats, Inbred Strains; Reference Values; Scopolamine; Seizures; Thalamus; Tubocurarine

1992
Drug-induced catalepsy as influenced by convulsant and anticonvulsant drugs.
    Neuropharmacology, 1973, Volume: 12, Issue:8

    Topics: Animals; Anticonvulsants; Arecoline; Bemegride; Caffeine; Catalepsy; Central Nervous System Stimulants; Drug Synergism; Ethosuximide; Haloperidol; Humans; Lobeline; Male; Mice; Mice, Inbred Strains; Nicotine; Nikethamide; Paraoxon; Pentylenetetrazole; Pilocarpine; Tetrabenazine; Tremorine; Trifluoperazine

1973
Different central effects of the 5-HT antagonists mianserine and cyproheptadine.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 198, Issue:2

    Topics: Animals; Behavior, Animal; Cyproheptadine; Dibenzazepines; Drug Antagonism; Electroshock; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Pilocarpine; Pyrazines; Reserpine; Salivation; Seizures; Serotonin Antagonists; Strychnine; Tremorine

1972
Time-drug modulations of photically evoked after-discharge patterns.
    Physiology & behavior, 1972, Volume: 8, Issue:6

    Topics: Amphetamine; Animals; Arousal; Atropine; Drug Synergism; Electrodes, Implanted; Electroencephalography; Evoked Potentials; Habituation, Psychophysiologic; Neural Pathways; Pentylenetetrazole; Photic Stimulation; Physostigmine; Pilocarpine; Rats; Thalamic Nuclei; Visual Cortex

1972
Kainic acid, bicuculline, pentylenetetrazol and pilocarpine elicit maximal dentate activation in the anesthetized rat.
    Epilepsy research, 1994, Volume: 18, Issue:1

    Topics: Anesthesia; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley

1994
The role of nitric oxide in chemically- and electrically-induced seizures in mice.
    Neuroscience letters, 1996, Oct-18, Volume: 217, Issue:2-3

    Topics: Animals; Convulsants; Electroshock; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Male; Mice; Muscarinic Agonists; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Pilocarpine; Seizures

1996
Electroencephalographic study of the effect of neurotoxin DSP-4 in iron model of chronic focal epilepsy.
    Indian journal of experimental biology, 1999, Volume: 37, Issue:5

    Topics: Animals; Benzylamines; Cerebral Cortex; Chlorides; Electroencephalography; Epilepsy; Ferric Compounds; Locus Coeruleus; Male; Neurotoxins; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar

1999
Increased sensitivity to seizures in mice lacking cellular prion protein.
    Epilepsia, 1999, Volume: 40, Issue:12

    Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; PrPC Proteins; Seizures

1999
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
    Journal of ethnopharmacology, 2000, Volume: 71, Issue:1-2

    Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Convulsants; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Lithium; Male; Mice; Muscarinic Agonists; Pentobarbital; Pentylenetetrazole; Pilocarpine; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Serotonin; Sleep

2000
Anticonvulsive activity of Butea monosperma flowers in laboratory animals.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Butea; Convulsants; Dyskinesia, Drug-Induced; Electroshock; Flowers; Lithium; Male; Pentylenetetrazole; Picrotoxin; Pilocarpine; Postural Balance; Rats; Rats, Sprague-Dawley; Seizures; Strychnine

2002
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
    Epilepsy research, 2002, Volume: 51, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Lithium; Male; Muscarinic Agonists; Pentylenetetrazole; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus

2002
N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities.
    Bioorganic & medicinal chemistry, 2003, Jan-02, Volume: 11, Issue:1

    Topics: Animals; Anticonvulsants; Binding Sites; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Models, Molecular; Pentylenetetrazole; Pilocarpine; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Toxicity Tests

2003
Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine.
    Brain research, 2003, Jan-17, Volume: 960, Issue:1-2

    Topics: Acoustic Stimulation; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroshock; Female; Muscarinic Agonists; Myoclonus; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Seizures

2003
Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L.
    Pharmacological research, 2003, Volume: 48, Issue:5

    Topics: Animals; Anticonvulsants; Artemisia; Central Nervous System Agents; Convulsants; Ethanol; Gas Chromatography-Mass Spectrometry; Lethal Dose 50; Male; Mice; Oils, Volatile; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Plant Leaves; Postural Balance; Rats; Rats, Wistar; Seizures; Solvents; Strychnine

2003
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
    Neuroscience, 2004, Volume: 126, Issue:3

    Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Muscarinic Antagonists; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Synapses

2004
Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae.
    Epilepsia, 2004, Volume: 45, Issue:11

    Topics: Animals; Animals, Newborn; Body Temperature; Brain; Cell Death; Disease Models, Animal; Female; Fever; Humans; Immunohistochemistry; Kainic Acid; Lipopolysaccharides; Lithium; Pentylenetetrazole; Pilocarpine; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures, Febrile

2004
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Cloning, Molecular; Convulsants; Drug Synergism; Epilepsy; Epilepsy, Reflex; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; N-Acetylglucosaminyltransferases; Neurons; Nipecotic Acids; Pentylenetetrazole; Pilocarpine; Psychomotor Disorders; Recombinant Proteins; Seizures; Tiagabine

2005
Anticonvulsant activity of ginseng on seizures induced by chemical convulsants.
    Epilepsia, 2005, Volume: 46, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Ginsenosides; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; N-Methylscopolamine; Neurons; Panax; Pentylenetetrazole; Phytotherapy; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures

2005
The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.
    Neuroscience, 2005, Volume: 136, Issue:2

    Topics: Alleles; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Convulsants; Electric Stimulation; Electrodes, Implanted; Epilepsy, Tonic-Clonic; Kainic Acid; Kindling, Neurologic; Mice; Mice, Knockout; Pentylenetetrazole; Phenotype; Pilocarpine; Seizures

2005
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
    Molecular and cellular biology, 2006, Volume: 26, Issue:1

    Topics: Animals; Antiporters; Bicuculline; Brain; Chloride-Bicarbonate Antiporters; Convulsants; Dentate Gyrus; Gene Targeting; Hydrogen-Ion Concentration; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; Seizures; Sensory Thresholds

2006
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Levetiracetam; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Pilocarpine; Piracetam; Seizures; Sensory Thresholds; Small-Conductance Calcium-Activated Potassium Channels

2006
Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats.
    Neuropharmacology, 2007, Volume: 53, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Hypnotics and Sedatives; Kainic Acid; Kindling, Neurologic; Male; Muscarinic Agonists; Pentylenetetrazole; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Rhodamine 123; Up-Regulation

2007
Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.
    Epilepsy & behavior : E&B, 2008, Volume: 13, Issue:1

    Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures

2008
Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy.
    British journal of pharmacology, 2008, Volume: 154, Issue:5

    Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Electroencephalography; Hippocampus; Lithium Chloride; Male; Pentylenetetrazole; Pilocarpine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Seizures; Sodium Channels

2008
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
    Epilepsia, 2009, Volume: 50, Issue:4

    Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Susceptibility; Electroencephalography; Electroshock; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Seizures

2009
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
    Epilepsia, 2009, Volume: 50, Issue:4

    Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Body Weight; Diet, Ketogenic; Disease Models, Animal; Electroencephalography; Epilepsy; Fenofibrate; Hypolipidemic Agents; Ketone Bodies; Lithium Chloride; Liver; Male; Organ Size; Pentylenetetrazole; Pilocarpine; PPAR alpha; Rats; Rats, Wistar; Reaction Time

2009
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
    Brain research bulletin, 2009, Jun-30, Volume: 79, Issue:5

    Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Organoselenium Compounds; Pentylenetetrazole; Pilocarpine; Quinoxalines; Rats; Rats, Wistar; Seizures; Time Factors; Treatment Outcome

2009
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:3

    Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; Receptor, Adenosine A2A; Seizures

2009
Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice.
    Nitric oxide : biology and chemistry, 2009, Volume: 21, Issue:2

    Topics: Analysis of Variance; Animals; Convulsants; Guanidines; Male; Mice; Nitric Oxide Synthase Type II; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus

2009
Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures.
    Neuroscience letters, 2010, Oct-29, Volume: 484, Issue:2

    Topics: Animals; Disease Models, Animal; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylscopolamine; Pentylenetetrazole; Pilocarpine; Receptors, Somatostatin; Seizures

2010
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
    Life sciences, 2010, Nov-20, Volume: 87, Issue:19-22

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Lipid Peroxidation; Male; Malonates; Mice; Nitroprusside; Organoselenium Compounds; Oxidative Stress; Pentylenetetrazole; Pilocarpine; Seizures; Thiobarbituric Acid Reactive Substances

2010
Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis.
    Epilepsy & behavior : E&B, 2010, Volume: 19, Issue:4

    Topics: Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroshock; Gene Expression Regulation; Hippocampus; Male; Neurons; Neuropeptide Y; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Seizures; Somatostatin

2010
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
    Epilepsy & behavior : E&B, 2011, Volume: 20, Issue:2

    Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Embryo, Mammalian; Exploratory Behavior; Male; Membrane Potentials; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Scorpion Venoms; Seizures; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Valproic Acid

2011
Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.
    Epilepsy & behavior : E&B, 2011, Volume: 22, Issue:3

    Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Antidepressive Agents; Behavior, Animal; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Green Fluorescent Proteins; Male; Mice; Pentylenetetrazole; Pilocarpine; Seizures; Zebrafish

2011
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
    Epilepsy & behavior : E&B, 2011, Volume: 22, Issue:4

    Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Compounding; Drug Interactions; Epilepsy; Gas Chromatography-Mass Spectrometry; Lipid Peroxidation; Male; Manihot; Motor Activity; Muscarinic Agonists; Pentylenetetrazole; Phytotherapy; Picrotoxin; Pilocarpine; Plant Preparations; Random Allocation; Rats; Rats, Wistar; Seizures; Superoxide Dismutase

2011
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
    Nature neuroscience, 2011, Dec-11, Volume: 15, Issue:2

    Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; Down-Regulation; Electric Stimulation; Epilepsy; ErbB Receptors; Female; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kv1.1 Potassium Channel; Male; Mice; Mice, Transgenic; Neuregulin-1; Neurons; Parvalbumins; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Pilocarpine; Potassium Channel Blockers; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Signal Transduction; Tyrphostins

2011
Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI.
    Brain topography, 2012, Volume: 25, Issue:4

    Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Convulsants; Dextrans; Disease Models, Animal; Electric Stimulation; Electroencephalography; Ferric Compounds; Inositol; Magnetic Resonance Imaging; Mice; Neurons; Pentylenetetrazole; Pilocarpine; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Rest; Seizures; Vibrissae

2012
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
    The European journal of neuroscience, 2012, Volume: 36, Issue:4

    Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agonists; Kainic Acid; Lithium; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures

2012
Cannabidivarin is anticonvulsant in mouse and rat.
    British journal of pharmacology, 2012, Volume: 167, Issue:8

    Topics: Animals; Anticonvulsants; Cannabinoids; Cannabis; Disease Models, Animal; Female; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Phytotherapy; Pilocarpine; Rats; Rats, Inbred WKY; Seizures

2012
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.
    Neuroscience, 2012, Dec-13, Volume: 226

    Topics: Animals; Convulsants; Epilepsy; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Lactalbumin; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Milk Proteins; N-Methylaspartate; Pentylenetetrazole; Pilocarpine; Rats; Tryptophan; Whey Proteins

2012
[Effect of acute stress stimulation on the seizure induction in epileptic model rats].
    Sheng li xue bao : [Acta physiologica Sinica], 2012, Dec-25, Volume: 64, Issue:6

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Lithium Chloride; Pentylenetetrazole; Pilocarpine; Rats; Seizures; Stress, Physiological

2012
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
    Nutritional neuroscience, 2013, Volume: 16, Issue:2

    Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred Strains; Microdialysis; Pentylenetetrazole; Pilocarpine; Seizures; Tea

2013
Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures.
    Cellular and molecular neurobiology, 2013, Volume: 33, Issue:6

    Topics: Acetamides; Animals; Brain; Catalase; Female; Lipid Peroxidation; Mice; Nitrites; Oxidative Stress; Pentylenetetrazole; Picrotoxin; Pilocarpine; Seizures; Strychnine

2013
Anticonvulsant screening of luteolin in four mouse seizure models.
    Neuroscience letters, 2013, Aug-29, Volume: 550

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Luteolin; Male; Mice; Pentylenetetrazole; Pilocarpine; Seizures

2013
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.
    British journal of pharmacology, 2013, Volume: 170, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Cannabinoids; Cannabis; Disease Models, Animal; Dose-Response Relationship, Drug; Hand Strength; Male; Mice; Mice, Inbred DBA; Motor Activity; Noise; Pentylenetetrazole; Phytotherapy; Pilocarpine; Plant Extracts; Plants, Medicinal; Protein Binding; Rats; Rats, Inbred WKY; Receptor, Cannabinoid, CB1; Seizures

2013
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety.
    Brain research, 2013, Sep-26, Volume: 1532

    Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Electroencephalography; Emotions; GABA Antagonists; GABA Modulators; Hippocampus; Male; Maze Learning; Pentylenetetrazole; Pilocarpine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, GABA-A; Theta Rhythm

2013
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures.
    Life sciences, 2013, Nov-06, Volume: 93, Issue:20

    Topics: alpha-MSH; Animals; Anti-Inflammatory Agents; Hippocampus; Interleukin-1beta; Male; Mice; Pentylenetetrazole; Pilocarpine; Seizures

2013
Elevated expression of pleiotrophin in pilocarpine-induced seizures of immature rats and in pentylenetetrazole-induced hippocampal astrocytes in vitro.
    Acta histochemica, 2014, Volume: 116, Issue:2

    Topics: Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Survival; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Male; Pentylenetetrazole; Pilocarpine; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Seizures

2014
In silico validation and structure activity relationship study of a series of pyridine-3-carbohydrazide derivatives as potential anticonvulsants in generalized and partial seizures.
    Central nervous system agents in medicinal chemistry, 2013, Volume: 13, Issue:2

    Topics: Animals; Anticonvulsants; Computer Simulation; Cornea; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Electroshock; Hippocampus; Hydrazones; Kindling, Neurologic; Mice; Molecular Structure; Neuroprotective Agents; Neurotoxins; Niacinamide; Pentylenetetrazole; Pilocarpine; Rotarod Performance Test; Seizures; Structure-Activity Relationship

2013
[Comparison of seizure induced by different drugs in ICR Mice].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2013, Volume: 42, Issue:6

    Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Pilocarpine

2013
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
    CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:5

    Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Deficiency; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pilocarpine; Potassium; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Tissue Culture Techniques; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels

2014
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
    Synapse (New York, N.Y.), 2014, Volume: 68, Issue:9

    Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Disease; Disease Models, Animal; Disulfides; Epilepsy; Hypoxia-Inducible Factor 1, alpha Subunit; Lithium Compounds; Male; Pentylenetetrazole; Pilocarpine; Random Allocation; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Sulfonamides

2014
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.
    European journal of medicinal chemistry, 2014, Aug-18, Volume: 83

    Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Chemistry Techniques, Synthetic; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Male; Mice; Motor Activity; Pentylenetetrazole; Pilocarpine; Rotarod Performance Test; Seizures; Structure-Activity Relationship

2014
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
    Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship

2014
Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring.
    Neuroscience, 2014, Oct-24, Volume: 279

    Topics: Animals; Avoidance Learning; Brain; Female; Kindling, Neurologic; Learning Disabilities; Male; Muscarinic Agonists; Muscarinic Antagonists; Pentylenetetrazole; Pilocarpine; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Receptors, Muscarinic; Scopolamine

2014
A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way.
    Epilepsy research, 2014, Volume: 108, Issue:9

    Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Disease Progression; Female; Male; Muscarinic Agonists; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus

2014
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
    CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:1

    Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Interneurons; Kindling, Neurologic; Lithium Compounds; Male; Mice, Transgenic; Nerve Degeneration; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Pentylenetetrazole; Pilocarpine; Status Epilepticus; Valproic Acid

2015
Contrasting effects of Na+, K+-ATPase activation on seizure activity in acute versus chronic models.
    Neuroscience, 2015, Jul-09, Volume: 298

    Topics: Animals; Antibodies; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; Gene Expression Regulation, Enzymologic; Hippocampus; Male; Mice, Inbred C57BL; Pentylenetetrazole; Pilocarpine; Rats; Sodium-Potassium-Exchanging ATPase; Statistics, Nonparametric; Status Epilepticus; Time Factors

2015
proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Jul-01, Volume: 35, Issue:26

    Topics: Action Potentials; Aminoquinolines; Animals; Brain-Derived Neurotrophic Factor; Carbachol; Cells, Cultured; Cerebral Cortex; Cholinergic Agonists; Convulsants; Disease Models, Animal; Embryo, Mammalian; Female; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pentylenetetrazole; Phospholipase C delta; Pilocarpine; Protein Precursors; Pyrimidines; Receptors, Nerve Growth Factor; Seizures

2015
Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid.
    Brain research, 2015, Oct-22, Volume: 1624

    Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Sparteine; Status Epilepticus

2015
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
    Neuropharmacology, 2015, Volume: 99

    Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; DNA Methylation; Hippocampus; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pilocarpine; Random Allocation; Rats, Wistar; Seizures; Status Epilepticus; Valproic Acid

2015
Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain.
    Clinical science (London, England : 1979), 2015, Volume: 129, Issue:12

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain Waves; Case-Control Studies; Disease Models, Animal; Electroencephalography; Enzyme Activation; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Female; Hippocampus; Humans; Insulin-Like Growth Factor I; Male; Middle Aged; Pentylenetetrazole; Phosphorylation; Pilocarpine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Time Factors; Up-Regulation; Young Adult

2015
Sulforaphane is anticonvulsant and improves mitochondrial function.
    Journal of neurochemistry, 2015, Volume: 135, Issue:5

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electron Transport Complex I; Electroshock; Epilepsy; Flurothyl; Hippocampus; Isothiocyanates; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mitochondria; Nerve Degeneration; Oxidative Stress; Pentylenetetrazole; Pilocarpine; Sulfoxides; Superoxide Dismutase

2015
Plic-1, a new target in repressing epileptic seizure by regulation of GABAAR function in patients and a rat model of epilepsy.
    Clinical science (London, England : 1979), 2015, Volume: 129, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Anticonvulsants; Autophagy-Related Proteins; Brain Waves; CA1 Region, Hippocampal; Carrier Proteins; Case-Control Studies; Cell Cycle Proteins; Child; Child, Preschool; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Antagonists; Genetic Vectors; Humans; Inhibitory Postsynaptic Potentials; Lentivirus; Male; Miniature Postsynaptic Potentials; Molecular Chaperones; Oligopeptides; Pentylenetetrazole; Pilocarpine; Pyramidal Cells; Rats, Sprague-Dawley; Receptors, GABA-A; Signal Transduction; Time Factors; Transduction, Genetic; Young Adult

2015
Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate.
    Chemico-biological interactions, 2015, Dec-05, Volume: 242

    Topics: Animals; Anticonvulsants; Behavior, Animal; Coumaric Acids; Male; Mice; Motor Activity; Muscle Relaxation; Pentylenetetrazole; Pilocarpine; Seizures

2015
Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
    Epilepsy & behavior : E&B, 2015, Volume: 53

    Topics: Animals; Biomarkers; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Female; Lithium; Male; Pentylenetetrazole; Pilocarpine; Prospective Studies; Rats; Reaction Time; ROC Curve; Seizures; Status Epilepticus

2015
The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.
    Epilepsia, 2016, Volume: 57, Issue:5

    Topics: Animals; Anticonvulsants; Bumetanide; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Electroshock; Epilepsy, Temporal Lobe; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Prodrugs

2016
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
    Epilepsy & behavior : E&B, 2016, Volume: 57, Issue:Pt A

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagonists; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Piracetam; Rats; Seizures; Status Epilepticus; Valproic Acid

2016
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
    Epilepsia, 2016, Volume: 57, Issue:7

    Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pentylenetetrazole; Pilocarpine; Seizures; Urate Oxidase; Uric Acid

2016
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
    Epilepsy research, 2016, Volume: 126

    Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; Electrocorticography; Epilepsy; Female; Immunohistochemistry; Male; Neuropeptide Y; Pentylenetetrazole; Phenobarbital; Pilocarpine; Proto-Oncogene Proteins c-fos; Seizures; Valproic Acid

2016
Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice.
    Epilepsy & behavior : E&B, 2016, Volume: 62

    Topics: Animals; Anticonvulsants; Behavior, Animal; Cinnamates; Depsides; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Pilocarpine; Rosmarinic Acid; Seizures

2016
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2016, Volume: 389, Issue:11

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; Diazepam; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Pilocarpine; Reaction Time; Rosmarinic Acid; Seizures; Sleep; Time Factors

2016
Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture.
    Journal of visualized experiments : JoVE, 2016, 12-22, Issue:118

    Topics: Animals; Disease Models, Animal; Electroacupuncture; Electrocorticography; Electromyography; Epilepsy, Temporal Lobe; Locomotion; Mice; Pentylenetetrazole; Pilocarpine; Rats; Sleep; Wakefulness

2016
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
    BMC research notes, 2017, Apr-26, Volume: 10, Issue:1

    Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nifedipine; Pentylenetetrazole; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley

2017
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
    Scientific reports, 2017, 05-10, Volume: 7, Issue:1

    Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Injections, Intraventricular; Kainic Acid; Mice, Inbred C57BL; Pentylenetetrazole; Pilocarpine; Pyramidal Cells; Severity of Illness Index; Triterpenes; Zebrafish

2017
Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos.
    Naunyn-Schmiedeberg's archives of pharmacology, 2017, Volume: 390, Issue:9

    Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Male; Mice; Pentylenetetrazole; Pilocarpine; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Terpenes; Up-Regulation

2017
EP2 receptor agonist ONO-AE1-259-01 attenuates pentylenetetrazole- and pilocarpine-induced seizures but causes hippocampal neurotoxicity.
    Epilepsy & behavior : E&B, 2017, Volume: 73

    Topics: Animals; Anticonvulsants; Dinoprostone; Hippocampus; Male; Mice; Neurons; Neurotoxicity Syndromes; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus

2017
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
    Journal of ethnopharmacology, 2018, Feb-15, Volume: 212

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electric Stimulation; Flumazenil; Male; Mice; Pentylenetetrazole; Pilocarpine; Plant Extracts; Plant Leaves; Plants, Medicinal; Random Allocation; Seizures; Senna Plant

2018
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
    Epilepsy research, 2018, Volume: 140

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Male; Mice, Inbred ICR; Pentylenetetrazole; Pilocarpine; Prostaglandin-Endoperoxide Synthases; Seizures

2018
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
    Molecular neurobiology, 2018, Volume: 55, Issue:11

    Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pentylenetetrazole; Pilocarpine; Ribosomes; RNA Polymerase I; RNA Precursors; RNA, Ribosomal; Seizures; Status Epilepticus

2018
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106

    Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epilepsy; Humans; Kainic Acid; Mice; Pentylenetetrazole; Pilocarpine; Saccharomyces cerevisiae

2018
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
    The Journal of toxicological sciences, 2018, Volume: 43, Issue:11

    Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Ibuprofen; Indazoles; Male; Mice, Inbred Strains; Neurotoxins; Nitric Oxide; Pentylenetetrazole; Pilocarpine; Seizures; Thalidomide

2018
Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats.
    Epilepsy research, 2019, Volume: 149

    Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; GABA-B Receptor Antagonists; Male; Pentylenetetrazole; Phosphinic Acids; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus

2019
Ivabradine possesses anticonvulsant and neuroprotective action in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Ivabradine; Male; Mice; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Pilocarpine; Protein Structure, Secondary; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures

2019
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 182

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, Neurologic; Male; Miotics; Pentylenetetrazole; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Seizures; Valproic Acid

2019
Status Epilepticus Increases Cell Proliferation and Neurogenesis in the Developing Rat Cerebellum.
    Cerebellum (London, England), 2020, Volume: 19, Issue:1

    Topics: Animals; Cell Proliferation; Cerebellum; Female; Lithium Chloride; Male; Neurogenesis; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus

2020
Modulatory effect of opioid ligands on status epilepticus and the role of nitric oxide pathway.
    Epilepsy & behavior : E&B, 2019, Volume: 101, Issue:Pt A

    Topics: Analgesics, Opioid; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Indazoles; Ligands; Lithium Chloride; Male; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Signal Transduction; Status Epilepticus

2019
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus.
    Scientific reports, 2020, 01-21, Volume: 10, Issue:1

    Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Electroencephalography; Male; Mice, Knockout; Mice, Transgenic; Muscle, Smooth, Vascular; Neurovascular Coupling; Pentylenetetrazole; Pilocarpine; Status Epilepticus; TRPC Cation Channels

2020
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
    Epilepsia, 2021, Volume: 62, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Mice; Muscarinic Agonists; Pentylenetetrazole; Phenols; Pilocarpine; Propofol; Rats; Receptors, GABA-A; Seizures; Status Epilepticus

2021
In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models.
    Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:4

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Pentylenetetrazole; Pilocarpine; Seizures; Strychnine

2020
Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice.
    Molecules (Basel, Switzerland), 2021, Nov-09, Volume: 26, Issue:22

    Topics: Animals; Anticonvulsants; Chondroitin Sulfates; Male; Mice; Molecular Docking Simulation; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus; Valproic Acid

2021
Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
    Epilepsia, 2022, Volume: 63, Issue:4

    Topics: Animals; Disease Models, Animal; Mice; Pentylenetetrazole; Pilocarpine; Pyrazoles; Seizures

2022
Pentylenetetrazole preconditioning attenuates severity of status epilepticus induced by lithium-pilocarpine in male rats: evaluation of opioid/NMDA receptors and nitric oxide pathway.
    Pharmacological reports : PR, 2022, Volume: 74, Issue:4

    Topics: Analgesics, Opioid; Animals; Anticonvulsants; Enzyme Inhibitors; Lithium; Male; N-Methylaspartate; Nitric Oxide; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Signal Transduction; Status Epilepticus

2022
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
    Neurochemical research, 2023, Volume: 48, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus; Valproic Acid

2023
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
    Journal of ethnopharmacology, 2023, Mar-01, Volume: 303

    Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Seizures; Strychnine; Water

2023
A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae.
    PloS one, 2023, Volume: 18, Issue:7

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; Larva; Pentylenetetrazole; Pilocarpine; Zebrafish

2023