pentylenetetrazole has been researched along with kainic acid in 158 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (12.03) | 18.7374 |
| 1990's | 46 (29.11) | 18.2507 |
| 2000's | 40 (25.32) | 29.6817 |
| 2010's | 43 (27.22) | 24.3611 |
| 2020's | 10 (6.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Freed, WJ; Michaelis, EK | 1 |
| Bellmann, R; Krause, JE; Marksteiner, J; Ortler, M; Sperk, G; Wahler, R | 1 |
| Fischer-Colbrie, R; Gruber, B; Mahata, M; Mahata, SK; Marksteiner, J; Sperk, G; Winkler, H | 1 |
| Bellmann, R; Gruber, B; Mahata, M; Marksteiner, J; Ortler, M; Sperk, G | 1 |
| Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Jope, RS; Kolasa, K; Li, X; Song, L | 1 |
| Garyaev, AP; Piotrovsky, LB; Poznyakova, LN | 1 |
| Hirai, Y; Kuraishi, Y; Minami, M; Nakai, S; Satoh, M; Yamaguchi, T | 1 |
| Artigas, F; de Vera, N; Martínez, E | 1 |
| Naquet, R | 1 |
| Bellmann, R; Humpel, C; Marksteiner, J; Saria, A; Sperk, G | 1 |
| Marksteiner, J; Prommegger, R; Sperk, G | 1 |
| De Barry, J; Mathis, C; Ungerer, A | 1 |
| Bellmann, R; Marksteiner, J; Ortler, M; Sperk, G | 1 |
| Albertson, TE; Joy, RM | 1 |
| Humpel, C; Marksteiner, J; Saria, A; Sperk, G | 1 |
| Curran, T; Hempstead, J; Macgregor-Leon, PF; Mitchelmore, C; Morgan, JI; Sonnenberg, JL | 1 |
| Kulhánková, I; Mares, P; Mirvaldová, H; Roztocilová, L; Velísek, L; Velísková, J | 1 |
| Marksteiner, J; Sperk, G | 1 |
| Lehmann, A | 1 |
| Balm, M; Coyle, JT; Markl, A; Zaczek, R | 1 |
| Ferrendelli, JA; Mirski, MA | 1 |
| Ault, B; Boyer, CE; Joyner, JL; Notrica, MA; Olney, MA; Soroko, FE; Wang, CM | 1 |
| Goping, G; Klatzo, I; Nitsch, C | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L | 1 |
| De Feo, MR; Mecarelli, O; Ricci, GF | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, W | 2 |
| Freed, WJ; Michaelis, EK; Michaelis, ML | 1 |
| Ben-Ari, Y; Charton, G; Riche, D; Tremblay, E | 1 |
| Ben-Ari, Y; Ghilini, G; Naquet, R; Riche, D; Tremblay, E | 1 |
| Javid, MJ; Stone, WE | 1 |
| Kaczmarek, L; Kamińska, B; Lasoń, W; Lukasiuk, K; Nowicka, DZ; Przewłocka, B; Przewłocki, R | 1 |
| Klitgaard, H; Laudrup, P | 1 |
| Davis, W; Penix, LP; Subramaniam, S | 1 |
| Ferrer, I; Planas, AM; Rodríguez Farré, E; Soriano, MA | 1 |
| Civenni, G; Hoyer, D; Pérez, J; Rizzi, M; Schüpbach, E; Tutka, P; Vezzani, A | 1 |
| Dunham, L; Guillet, R | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Curran, T; Hammer, RE; Kasof, GM; Maika, SD; Mandelzys, A; Morgan, JI | 1 |
| Civenni, G; Messali, S; Monno, A; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Ahmad, I; Lauretti, GR; Pleuvry, BJ | 1 |
| Kaczmarek, L; Kamińska, B; Lukasiuk, K | 1 |
| Keith, LD; Roberts, AJ | 1 |
| Sowell, KL; Stringer, JL | 1 |
| Belknap, JK; Crabbe, JC; Merrill, CM | 1 |
| Blisard, KS; Fagin, K; Falivena, P; Harrington, DA; Olejniczak, P; Privitera, MD; Scremin, OU; Taylor, KL | 1 |
| Hiraia, K; Hishinuma, F; Inokuchi, K; Inoue, M; Kato, A; Ozawa, F | 1 |
| Baldy-Moulinier, M; N'gouemo, P; Nguemby-Bina, C | 1 |
| Camón, L; de Vera, N; Giménez-Llort, L; Martínez, E | 2 |
| Akarsu, ES; Ayhan, IH; Cağlar, S; Inan, LE; Kuli, P; Palaoğlu, O; Uysal, H | 1 |
| Drewes, LR; Gerhart, DZ; Gronlund, KM; Leino, RL; McCall, AL | 1 |
| Gallyas, F; Ribak, CE; Séress, L; Tóth, P; Tóth, Z | 1 |
| Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV | 1 |
| De Vera, N; Giménez-Llort, L; Martínez, E | 1 |
| Ebert, U; Koch, M | 1 |
| Panegyres, PK | 1 |
| Becker, HC; Diaz-Granados, JL; Veatch, LM | 1 |
| Nakanishi, H; Tominaga, K; Yamamoto, K; Yasuda, Y | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Behrens, A; Sibilia, M; Wagner, EF | 1 |
| Górecki, DC; Kaczmarek, L; Lukasiuk, K; Simons, JP; Szklarczyk, A | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M | 1 |
| Choe, BK; Kim, SK; Kwon, GY; Shin, SW | 1 |
| Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS | 1 |
| Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R | 1 |
| Conti, M; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Bac, P; Delcourt, P; Herrenknecht, C; Maurois, P; Stables, JP; Vamecq, J | 1 |
| Cole, TB; Palmiter, RD; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Mack, KJ; Nanda, SA | 1 |
| Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M | 1 |
| French-Mullen, J; Gobbi, M; Moneta, D; Mulé, F; Ravizza, T; Vezzani, A | 1 |
| Hohmann, JG; Miller, NS; Palmiter, RD; Pyati, U; Rust, NC; Szot, P; Weinshenker, D; White, SS | 1 |
| Berkovic, SF; Clark, M; Drago, J; Finkelstein, DI; Horne, MK; Massalas, JS; McColl, C; Powney, E; Ross, SA; Wong, JY | 1 |
| Dubé, C; Koning, E; Nehlig, A | 1 |
| Aoki, T; Konishi, Y; Matsu-ura, T; Mikoshiba, K; Naranjo, JR; Tamura, TA | 1 |
| Aznavour, N; Carmant, L; Descarries, L; Mamer, OA; Meilleur, S; Psarropoulou, C | 1 |
| Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ | 1 |
| Jessberger, S; Kempermann, G | 1 |
| Cavazos, JE; Cross, DJ; Jones, SM | 1 |
| Bastlund, JF; Jennum, P; Mohapel, P; Vogel, V; Watson, WP | 1 |
| Auladell, C; Bellmann, A; Domínguez, MI; Ferrer, I; Journot, L; Valente, T | 1 |
| Barczynski, B; Tutka, P; Wielosz, M | 1 |
| Boissé, L; Heida, JG; Pittman, QJ | 1 |
| Lian, XY; Stringer, JL; Zhang, ZZ | 1 |
| González-Trujano, ME; Hong, E; López-Meraz, ML; Neri-Bazán, L; Rocha, LL | 1 |
| Barton, ME; Shannon, HE | 1 |
| Coulson, JM; Mori, N; Morii, H; Nakano, I; Yamada, T | 1 |
| Cheng, IH; Gerstein, H; Mucke, L; Palop, JJ; Roberson, ED; Scearce-Levie, K; Wu, T; Yan, F; Yu, GQ | 1 |
| Liu, X; Yang, H; Yang, J; Yang, Z | 1 |
| Chaix, Y; Ferraro, TN; Lapouble, E; Martin, B | 1 |
| Ramsdell, JS; Tiedeken, JA | 1 |
| Bolkvadze, T; Kigyradze, T; Kiladze, M; Kuchiashvili, N; Nozadze, M; Pkhakadze, V; Solomonia, R; Zhvania, M | 1 |
| de Lecea, L; Hochgeschwender, U; Johnson, B; Qiu, C; Tallent, MK; Zeyda, T | 1 |
| Albert, GW; Howard, MA; Schnizler, MK; Severson, MA; Welsh, MJ; Wemmie, JA; Ziemann, AE | 1 |
| Glickstein, SB; Koeller, HB; Ross, ME | 1 |
| Bachstetter, A; Barnes, GN; Blalock, EM; Gant, JC; Hauser, KF; Kotick, J; Li, Y; Mervis, R; Schauwecker, PE; Smith, GM; Thibault, O; Yang, J | 1 |
| Jain, R; Kaur, N; Krishnamoorthy, S; Meena, CL; Monga, V; Pawar, C; Rajput, SK; Sharma, SS | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Dassesse, D; Gillard, M; Hanon, E; Kaminski, RM; Klitgaard, H; Leclercq, K; Lorent, G; Matagne, A | 1 |
| Ingole, S; Jain, G; Jain, R; Kaur, N; Meena, CL; Monga, V; Rajput, SK; Sharma, SS; Singh, JN | 1 |
| Godlevskii, LS; Kobolev, EV; Kresyun, VI | 1 |
| Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG | 1 |
| Cloix, JF; Hévor, T; Martin, B; Tahi, Z | 1 |
| Bergbower, E; Hardwick, JM; Hartman, AL; Kennedy, M; Zheng, X | 1 |
| French, A; Gasior, M; Hartman, AL; Rogawski, MA; Yankura, J | 1 |
| Abe, K; Hasebe, N; Hosoi, R; Inoue, O; Sugiyama, E | 1 |
| Bastlund, JF; Gill, DA; Reynolds, DS; Ryan, CL; Tasker, RA; Watson, WP | 1 |
| Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S | 1 |
| Paz, C; Retana-Márquez, S; Rubio, C; Rubio-Osornio, M; Verónica Custodio, ML | 1 |
| Claycomb, RJ; Hewett, JA; Hewett, SJ | 2 |
| Chen, L; Kong, S; Qian, B; Sun, Y; Wan, L; Wang, Y; Wang, ZY; Wu, Z; Zhang, B; Zhang, F | 1 |
| Beleboni, RO; Cunha, AO; dos Santos, WF; Fachim, HA; Faggion, SA; Gavin, AS; Pereira, AM | 1 |
| Borsotto, M; Coppola, T; Gandin, C; Heurteaux, C; Labbal, F; Mazella, J; Moha Ou Maati, H; Veyssiere, J; Widmann, C | 1 |
| Brandt, C; Löscher, W; Rattka, M | 1 |
| Dolce, A; Hardwick, JM; Hartman, AL; Santos, P | 1 |
| Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C | 1 |
| Dhir, A; Rogawski, MA; Zolkowska, D | 1 |
| Chang, P; Walker, MC; Williams, RS | 1 |
| Ahsan, MJ; Stables, JP | 1 |
| Chen, Y; Hu, L; Hua, N; Zeng, L; Zhang, H | 1 |
| Gmiro, VE; Serdyuk, SE; Veselkina, OS | 1 |
| Kamiński, K; Obniska, J; Wiklik, B | 1 |
| Hutchinson, E; Meyerand, ME; Sayin, U; Sutula, T | 1 |
| Harrison, FE; Kang, JQ; Kennard, JA; Warner, TA | 1 |
| Japaridze, NJ; Ksovreli, M; Lordkipanidze, TG; Zhvania, MG | 1 |
| Chen, X; Chen, Y; Cheng, L; Deng, W; Li, J; Li, Y; Lü, Y; Mi, X; Wang, N; Wang, X; Wang, Z; Xu, X; Zhang, Y | 1 |
| Medina-Ceja, L; Villalpando-Vargas, F | 1 |
| Díaz-Ruíz, A; Flores-Espinosa, P; Heras-Romero, Y; Juárez-Rebollar, D; Manjarrez, J; Méndez-Armenta, M; Nava-Ruíz, C; Zaga-Clavellina, V | 1 |
| Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L | 1 |
| Atkinson, EW; Coleman, JE; Hoang-Minh, LB; Le, MM; Parker, AK; Sarkisian, MR; Semple-Rowland, S; Smith, TS; Ugartemendia, G | 1 |
| Ji, Y; Jiang, N; Jin, J; Lin, W; Wang, Z; Wu, H; Zhao, Y; Zhu, H | 1 |
| Adongo, DW; Mante, PK; Woode, E | 1 |
| Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ | 1 |
| Li, Y; Liu, F; Lu, S; Tian, X; Wang, X; Xu, X; Yang, Q; Yang, Y; Zhang, Y; Zheng, F | 1 |
| Huang, H; Lu, X; Luo, Z; Qiu, X; Tang, S; Xu, Z; Zhang, Y | 1 |
| da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R | 1 |
| Ali, ES; Atanasova, M; da Conceição Machado, K; da Silva Lopes, L; de Carvalho Melo-Cavalcante, AA; de Sousa Rios, MA; Dimitrova Tchekalarova, J; Găman, AM; Găman, MA; Islam, MA; Islam, MT; Khan, IN; Luiz Gomes, A; Mishra, SK; Mubarak, MS; Paz, MFCJ; Shill, MC; Yele, S | 1 |
| Drexel, M; Kofler, B; Sperk, G; Sternberg’, F | 1 |
| Acar Arslan, E; Cansu, A; Dilber, B; Diler Durgut, B; Gürgen, SG; İnce, İ; Kamaşak, T; Şahin, S; Yazar, U | 1 |
| Díaz-Ruíz, A; Flores-Espinosa, P; Manjarrez, J; Méndez-Armenta, M; Nava-Ruíz, C; Ruíz-Díaz, A; Yescas-Gómez, P; Zaga-Clavellina, V | 1 |
| Díaz-Ruíz, A; Méndez-Armenta, M; Munguía-Martínez, MF; Nava-Ruíz, C; Ruíz-Díaz, A; Yescas-Gómez, P | 1 |
| Hong, Z; Sun, W; Wang, Y; Wu, X; Xu, L; Zhang, L; Zhu, G | 1 |
| Auer, T; Erker, T; Schreppel, P; Schwarzer, C | 1 |
| Fan, Y; Hou, C; Jiang, G; Peng, S; Tang, F; Wang, X; Wang, Y; Yang, J; Yu, J | 1 |
| Adhikari, A; Copping, NA; Petkova, SP; Silverman, JL | 1 |
| Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH | 1 |
| de Oliveira, DL; Dos Santos, TG; Linazzi, AM; Moro, L; Rech, G | 1 |
| Cheng, Y; Cui, Y; Huang, W; Li, S; Liu, W; Sun, H; Xin, W; Zhang, M; Zhang, Y; Zhu, W | 1 |
| Barker-Haliski, M; Knox, KM; White, HS; Zierath, DK | 1 |
| Adeyemi, OO; Afolayan, O; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Nwose, E; Olubodun-Obadun, TG; Umukoro, S | 1 |
| Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H | 1 |
| Chen, Y; Gu, Y; Liu, Z; Ma, Y; Sun, H; Tao, K; Tian, X; Wang, X; Wu, J; Zhang, X | 1 |
| Ameli, C; Cordero-Maldonado, ML; Crawford, AD; Donato, C; Martins, TG; Mombaerts, L; Peri, F; Skupin, A; Soliman, R | 1 |
2 review(s) available for pentylenetetrazole and kainic acid
| Article | Year |
|---|---|
Chemoconvulsant-induced seizure susceptibility: toward a common genetic basis?
Topics: Animals; Carbolines; Chromosome Mapping; Chromosomes; Convulsants; GABA Agonists; Genetic Predisposition to Disease; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Potassium Channels; Quantitative Trait Loci; Seizures | 2007 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Epilepsy, Reflex; Flurothyl; gamma-Aminobutyric Acid; Humans; Kainic Acid; Kindling, Neurologic; Muscarinic Agonists; Papio; Penicillins; Pentylenetetrazole; Pilocarpine; Tetanus Toxin; Zinc Compounds | 2010 |
156 other study(ies) available for pentylenetetrazole and kainic acid
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Glutamic acid and ethanol dependence.
Topics: Alcoholism; Animals; Brain Chemistry; Ethanol; Excitatory Amino Acid Antagonists; Glutamates; Humans; Kainic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome; Time Factors | 1978 |
Limbic seizures cause pronounced changes in the expression of neurokinin B in the hippocampus of the rat.
Topics: Animals; Hippocampus; Immunohistochemistry; Kainic Acid; Limbic System; Male; Neurokinin B; Nucleic Acid Hybridization; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Substance P; Tachykinins | 1992 |
Temporal lobe epilepsy of the rat: differential expression of mRNAs of chromogranin B, secretogranin II, synaptin/synaptophysin and p65 in subfield of the hippocampus.
Topics: Animals; Calcium-Binding Proteins; Chromogranin B; Chromogranins; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Membrane Glycoproteins; Membrane Proteins; Nerve Tissue Proteins; Pentylenetetrazole; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synaptophysin; Synaptotagmin I; Synaptotagmins | 1992 |
Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat.
Topics: Animals; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Neurons; Neuropeptide Y; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Somatostatin | 1992 |
The prodynorphin system in the rat hippocampus is differentially influenced by kainic acid and pentetrazole.
Topics: Animals; Autoradiography; Enkephalins; Hippocampus; In Situ Hybridization; In Vitro Techniques; Kainic Acid; Male; Pentylenetetrazole; Protein Precursors; Rats; Rats, Wistar; Reference Values; RNA, Messenger; Seizures; Sulfur Radioisotopes | 1992 |
Adrenalectomy potentiates immediate early gene expression in rat brain.
Topics: Adrenalectomy; Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Gene Expression; Genes; Glucocorticoids; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Pentylenetetrazole; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1992 |
Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice.
Topics: Animals; Cerebral Ventricles; Dipeptides; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 1991 |
Convulsants induce interleukin-1 beta messenger RNA in rat brain.
Topics: Animals; Brain; Convulsants; Dexamethasone; Diazepam; DNA; Gene Expression; Interleukin-1; Kainic Acid; Kinetics; Male; Nucleic Acid Hybridization; Organ Specificity; Pentylenetetrazole; Rats; Rats, Inbred Strains; RNA; RNA, Messenger | 1990 |
Differential response of rat brain polyamines to convulsant agents.
Topics: Animals; Biogenic Polyamines; Body Weight; Brain; Convulsants; Hexachlorocyclohexane; Kainic Acid; Male; Ornithine Decarboxylase; Pentylenetetrazole; Picrotoxin; Putrescine; Rats; Rats, Inbred Strains; Sesterterpenes; Spermidine; Spermine | 1991 |
Epileptic manifestations and influence on sleep in the baboon Papio papio.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tonic-Clonic; Kainic Acid; Limbic System; Papio; Pentylenetetrazole; Photic Stimulation; Sleep Stages; Status Epilepticus | 1991 |
Differential changes in tachykinins in the rat brain after drug-induced seizures.
Topics: Animals; Brain; Kainic Acid; Kindling, Neurologic; Male; Neuropeptides; Organ Specificity; Pentylenetetrazole; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Seizures; Tachykinins | 1991 |
Effect of anticonvulsant treatment on kainic acid-induced increases in peptide levels.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamate Decarboxylase; Kainic Acid; Male; Neuropeptide Y; Neuropeptides; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Somatostatin | 1990 |
NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Seizures | 1990 |
Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat.
Topics: Animals; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Neuropeptide Y; Nucleic Acid Hybridization; Pentylenetetrazole; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1990 |
Convulsant-induced changes in perforant path-dentate gyrus excitability in urethane anesthetized rats.
Topics: Animals; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Hexachlorocyclohexane; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Pronounced increases in brain levels of calcitonin gene-related peptide after kainic acid induced seizures.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Glutamate Decarboxylase; Kainic Acid; Male; Mannitol; Pentylenetetrazole; Radioimmunoassay; Rats; Rats, Inbred Strains; Seizures | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA-Binding Proteins; Electroshock; Gene Expression Regulation; Immunoblotting; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Seizures; Transcription Factors | 1989 |
Ethosuximide affects both pentylenetetrazole- and kainate-induced clonic seizures but differentiates between tonic-clonic seizures.
Topics: Animals; Anticonvulsants; Ethosuximide; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1989 |
Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold.
Topics: Animals; Cysteamine; Dose-Response Relationship, Drug; Epilepsy; Frontal Lobe; Glutamate Decarboxylase; Kainic Acid; Kindling, Neurologic; Male; Neuropeptide Y; Pentylenetetrazole; Rats; Rats, Inbred Strains; Somatostatin; Time Factors | 1988 |
Pentylenetetrazol seizure threshold and extracellular levels of cortical amino acids in taurine-deficient kittens.
Topics: Amino Acids; Animals; Cats; Cerebral Cortex; Epilepsy; Extracellular Space; Female; Kainic Acid; Male; Pentylenetetrazole; Taurine | 1987 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diazepam; Electroencephalography; Hippocampus; Injections; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
Anterior thalamic mediation of generalized pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Behavior, Animal; Bicuculline; Cerebral Cortex; Electroencephalography; Female; Guinea Pigs; Kainic Acid; Microinjections; Muscimol; Pentylenetetrazole; Seizures; Stereotaxic Techniques; Thalamic Nuclei; Vigabatrin | 1986 |
Pro-convulsant actions of theophylline and caffeine in the hippocampus: implications for the management of temporal lobe epilepsy.
Topics: Animals; Caffeine; Convulsants; Drug Interactions; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline | 1987 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; Epilepsy; Kainic Acid; Methionine Sulfoximine; Pentylenetetrazole; Pyridoxine; Rabbits; Seizures | 1986 |
Atropine reversal of kainic acid-induced decrease in the leptazol convulsive threshold.
Topics: Animals; Atropine; Kainic Acid; Male; Mice; Parasympathetic Nervous System; Pentylenetetrazole; Pyrrolidines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1981 |
Status epilepticus and brain maturation.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Female; Kainic Acid; Limbic System; Male; Pentylenetetrazole; Pyrrolidines; Rats; Status Epilepticus | 1984 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrrolidines; Seizures; Succinimides; Trimethadione; Valproic Acid | 1981 |
Convulsant action of pentetrazol in rats with selective lesions of the hippocampal pyramidal cells with intracerebroventricular kainic acid.
Topics: Animals; Convulsants; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Pentylenetetrazole; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Inbred Strains | 1982 |
Chronic ethanol intake and synaptosomal glutamate binding activity.
Topics: Alcoholism; Animals; Brain; Calcium; Ethanol; Glutamates; Humans; Kainic Acid; Kinetics; Pentylenetetrazole; Rats; Synaptosomes | 1980 |
Alterations in local glucose consumption following systemic administration of kainic acid, bicuculline or metrazol.
Topics: Animals; Bicuculline; Brain; Convulsants; Deoxyglucose; Glucose; Kainic Acid; Male; Pentylenetetrazole; Pyrrolidines; Rats | 1981 |
Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy.
Topics: Animals; Bicuculline; Brain; Deoxy Sugars; Deoxyglucose; Electric Conductivity; Glucose; Kainic Acid; Male; Organ Specificity; Pentylenetetrazole; Pyrrolidines; Rats; Seizures | 1981 |
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrrolidines; Seizures | 1980 |
Seizure related changes in the regulation of opioid genes and transcription factors in the dentate gyrus of rat hippocampus.
Topics: Animals; Behavior, Animal; Dentate Gyrus; DNA; Enkephalins; Gene Expression Regulation; Genes, fos; Genes, jun; Kainic Acid; Male; Opioid Peptides; Pentylenetetrazole; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Seizures; Transcription Factor AP-1; Transcription Factors | 1995 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Drug Synergism; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Receptors, Glutamate; Seizures | 1993 |
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Cerebrovascular Circulation; Enzyme Inhibitors; Indazoles; Kainic Acid; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Regional expression of inducible heat shock protein-70 mRNA in the rat brain following administration of convulsant drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain Chemistry; Convulsants; Gene Expression Regulation; Hexachlorocyclohexane; HSP70 Heat-Shock Proteins; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Organ Specificity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1994 |
Functional effects of D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2 and differential changes in somatostatin receptor messenger RNAs, binding sites and somatostatin release in kainic acid-treated rats.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding Sites; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Sequence Data; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; RNA, Messenger; Seizures; Somatostatin | 1995 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Purinergic P1; Seizures; Sex Factors; Strychnine | 1995 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats.
Topics: Animals; Animals, Genetically Modified; Base Sequence; beta-Galactosidase; Binding Sites; Blotting, Northern; Cell Death; Cell Nucleus; DNA Damage; Gene Expression; Genes, fos; Genes, Immediate-Early; Hippocampus; Kainic Acid; Kinetics; Mice; Mice, Transgenic; Molecular Sequence Data; Neurons; Oligodeoxyribonucleotides; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats; Recombinant Fusion Proteins; Time Factors; Transcription Factor AP-1 | 1995 |
Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats.
Topics: Animals; Antibodies; Chronic Disease; Disease Susceptibility; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neurons; Neuropeptide Y; Pentylenetetrazole; Potassium Chloride; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Pentylenetetrazole; Seizures | 1994 |
Seizures-evoked activation of transcription factors.
Topics: Animals; Brain; DNA; Kainic Acid; Pentylenetetrazole; Protein Binding; Proto-Oncogene Proteins c-jun; Rats; Seizures; Transcription Factors | 1994 |
Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice.
Topics: Animals; Corticosterone; Disease Susceptibility; Kainic Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Receptors, Mineralocorticoid; Seizures; Strychnine | 1994 |
Kainic acid, bicuculline, pentylenetetrazol and pilocarpine elicit maximal dentate activation in the anesthetized rat.
Topics: Anesthesia; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley | 1994 |
Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Arousal; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Handling, Psychological; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Experimental seizures in the frog (Rana pipiens).
Topics: Animals; Behavior, Animal; Bicuculline; Brain; Cisplatin; Convulsants; Electroencephalography; Kainic Acid; Pentylenetetrazole; Rana pipiens; Seizures; Strychnine | 1994 |
Increase in activin beta A mRNA in rat hippocampus during long-term potentiation.
Topics: Activins; Animals; Base Sequence; Convulsants; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Inhibins; Kainic Acid; Long-Term Potentiation; Male; Molecular Sequence Data; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures | 1996 |
Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Analysis of Variance; Animals; Anticonvulsants; Body Temperature; Central Nervous System; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Ethanol; Excitatory Amino Acid Agonists; Kainic Acid; Male; Medicine, African Traditional; Mice; Pentylenetetrazole; Plant Extracts; Plant Leaves; Plants, Medicinal; Poisoning; Rats; Rats, Wistar; Seizures | 1996 |
Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine.
Topics: Aminopyrine; Analysis of Variance; Animals; Convulsants; Drug Evaluation, Preclinical; Evaluation Studies as Topic; Excitatory Amino Acid Agonists; Frontal Lobe; Hexachlorocyclohexane; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Putrescine; Rats; Rats, Wistar; Sesterterpenes | 1996 |
Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats.
Topics: Animals; Anticonvulsants; Blood Glucose; Convulsants; Drug Evaluation, Preclinical; Glucose; Hypoglycemic Agents; Insulin; Kainic Acid; Male; Ouabain; Penicillins; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Seizures | 1996 |
Chronic seizures increase glucose transporter abundance in rat brain.
Topics: Animals; Brain; Chronic Disease; Glucose Transporter Type 1; Glucose Transporter Type 3; Immunoblotting; Immunohistochemistry; Kainic Acid; Male; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Reference Values; Seizures; Time Factors | 1996 |
A common morphological response of astrocytes to various injuries: "dark" astrocytes. A light and electron microscopic analysis.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Craniocerebral Trauma; Female; Kainic Acid; Male; Microscopy, Electron; Neurons; Pentylenetetrazole; Rats; Rats, Wistar | 1997 |
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Injections, Intraperitoneal; Injections, Intraventricular; Kainic Acid; Male; Melatonin; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Pentylenetetrazole; Quinolinic Acid; Seizures | 1998 |
Long-term effects of status epilepticus induced by kainic acid on hippocampal polyamines.
Topics: Animals; Behavior, Animal; Biogenic Polyamines; Chromatography, High Pressure Liquid; Convulsants; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Status Epilepticus; Weight Gain | 1998 |
Analysis of chemically-induced alterations of the motor activity in rats.
Topics: 4-Aminopyridine; Animals; Convulsants; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Wistar; Sodium Chloride; Status Epilepticus; Video Recording | 1998 |
Deficient sensorimotor gating following seizures in amygdala-kindled rats.
Topics: Acoustic Stimulation; Amygdala; Analysis of Variance; Animals; Cues; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Inhibition, Psychological; Kainic Acid; Kindling, Neurologic; Pentylenetetrazole; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia; Seizures | 1998 |
The effects of excitotoxicity on the expression of the amyloid precursor protein gene in the brain and its modulation by neuroprotective agents.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; Brain; Dizocilpine Maleate; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Male; Neuroprotective Agents; Neurotoxins; Organ Specificity; Pentobarbital; Pentylenetetrazole; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic; Trypsin Inhibitor, Kunitz Soybean | 1998 |
Repeated ethanol withdrawal experience selectively alters sensitivity to different chemoconvulsant drugs in mice.
Topics: Animals; Body Weight; Convulsants; Ethanol; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred C3H; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome | 1998 |
Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E.
Topics: Animals; Blotting, Northern; Cathepsin D; Cathepsin E; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Immunohistochemistry; Intracellular Membranes; Kainic Acid; Male; Neurons; Neurotoxins; Pentylenetetrazole; Rats; Rats, Wistar; RNA, Messenger | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.
Topics: Animals; Animals, Newborn; Apoptosis; Base Sequence; Cell Division; Excitatory Amino Acid Agonists; Fibroblasts; GABA Antagonists; Gene Expression Regulation, Developmental; Hippocampus; Homozygote; Kainic Acid; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagens; Mutation; Neurons; Pentylenetetrazole; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-jun; Seizures; Stress, Physiological; Ultraviolet Rays | 1999 |
Differential seizure-induced and developmental changes of neurexin expression.
Topics: Aging; Animals; Animals, Newborn; Gene Expression; Isomerism; Kainic Acid; Male; Nerve Tissue Proteins; Pentylenetetrazole; Rats; Rats, Wistar; RNA Splicing; Seizures | 1999 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Mice, Inbred DBA; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1999 |
Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells.
Topics: Animals; Dopamine; Gene Expression Regulation, Neoplastic; Glioma; Glutamic Acid; Haloperidol; Kainic Acid; Muscimol; Neuropeptide Y; Pentylenetetrazole; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Mice; Mollusk Venoms; Oocytes; Pentylenetetrazole; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Sound; Xenopus | 2000 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; PrPC Proteins; Seizures | 1999 |
Modulatory role of neuropeptides in seizures induced in rats by stimulation of glutamate receptors.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Kainic Acid; Male; Neuropeptide Y; Neuropeptides; Octreotide; Pentylenetetrazole; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neuropeptide Y; Receptors, Somatostatin; Seizures; Somatostatin | 2000 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electroshock; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Magnesium Deficiency; Mice; N-Methylaspartate; Patch-Clamp Techniques; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Seizures; Sodium Channel Blockers; Structure-Activity Relationship; Synaptosomes; Tumor Cells, Cultured | 2000 |
Seizures and neuronal damage in mice lacking vesicular zinc.
Topics: Animals; Bicuculline; Carrier Proteins; Cation Transport Proteins; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Flurothyl; Genetic Predisposition to Disease; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Metallothionein 3; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Seizures; Synapses; Synaptic Vesicles; Zinc | 2000 |
Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Kainic Acid; Male; Neuronal Plasticity; Pentylenetetrazole; Physical Stimulation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Somatosensory Cortex; Touch; Vibrissae | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Guanosine; Hippocampus; Hypoxanthine; Inosine; Kainic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Xanthine | 2000 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Agonists; Isoxazoles; Kainic Acid; Mice; Mice, Inbred DBA; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Phthalazines; Propionates; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Structure-Activity Relationship | 2000 |
Plastic changes in neuropeptide Y receptor subtypes in experimental models of limbic seizures.
Topics: Animals; Anticonvulsants; Arginine; Blotting, Western; Electroencephalography; Epilepsy; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Neuronal Plasticity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 2000 |
Genetic comparison of seizure control by norepinephrine and neuropeptide Y.
Topics: Animals; Dopamine beta-Hydroxylase; Exercise Test; Flurothyl; Genetic Predisposition to Disease; Handling, Psychological; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Knockout; Neuropeptide Y; Norepinephrine; Pentylenetetrazole; Phenotype; Seizures | 2001 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Genotype; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Potassium Channel Blockers; Receptors, GABA-A; Receptors, Nicotinic; Seizures; Strychnine | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Lithium; Male; Muscarinic Agonists; Pentylenetetrazole; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus | 2002 |
Seizure-mediated neuronal activation induces DREAM gene expression in the mouse brain.
Topics: Animals; Calcium-Binding Proteins; Convulsants; Cycloheximide; Dizocilpine Maleate; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Kv Channel-Interacting Proteins; Male; Mice; Neurons; Neuroprotective Agents; Pentylenetetrazole; Protein Synthesis Inhibitors; Repressor Proteins; RNA, Messenger; Seizures; Time Factors | 2002 |
Pentylenetetrazol-induced seizures in immature rats provoke long-term changes in adult hippocampal cholinergic excitability.
Topics: Acetylcholine; Age Factors; Animals; Animals, Newborn; Cholinergic Fibers; Cholinesterase Inhibitors; Convulsants; Cortical Synchronization; Culture Techniques; Epilepsy, Generalized; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Long-Term Potentiation; Membrane Potentials; Pentylenetetrazole; Physostigmine; Rats; Rats, Sprague-Dawley | 2003 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Seizures | 2003 |
Adult-born hippocampal neurons mature into activity-dependent responsiveness.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cellular Senescence; Female; Gene Expression; Genes, Immediate-Early; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Pentylenetetrazole; Phosphopyruvate Hydratase; Seizures | 2003 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Muscarinic Antagonists; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Synapses | 2004 |
Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry.
Topics: Animals; Body Temperature; Cerebral Cortex; Electrodes, Implanted; Electroencephalography; Electromyography; Epilepsy; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Telemetry; Time Factors; Wakefulness | 2004 |
Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Convulsants; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Gene Expression; Genes, Tumor Suppressor; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Limbic System; Male; Mice; Mice, Inbred ICR; Neurons; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Tissue Distribution; Transcription Factors; Zinc Fingers | 2004 |
Convulsant and anticonvulsant effects of bupropion in mice.
Topics: Animals; Anticonvulsants; Bupropion; Convulsants; Dose-Response Relationship, Drug; Electroshock; Kainic Acid; Male; Mice; Pentylenetetrazole; Seizures; Survival Rate | 2004 |
Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Cell Death; Disease Models, Animal; Female; Fever; Humans; Immunohistochemistry; Kainic Acid; Lipopolysaccharides; Lithium; Pentylenetetrazole; Pilocarpine; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures, Febrile | 2004 |
Anticonvulsant activity of ginseng on seizures induced by chemical convulsants.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Ginsenosides; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; N-Methylscopolamine; Neurons; Panax; Pentylenetetrazole; Phytotherapy; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures | 2005 |
5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Complex Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; Kainic Acid; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Seizures; Serotonin Receptor Agonists; Status Epilepticus | 2005 |
The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.
Topics: Alleles; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Convulsants; Electric Stimulation; Electrodes, Implanted; Epilepsy, Tonic-Clonic; Kainic Acid; Kindling, Neurologic; Mice; Mice, Knockout; Pentylenetetrazole; Phenotype; Pilocarpine; Seizures | 2005 |
Site-specific phosphorylation of SCG10 in neuronal plasticity: role of Ser73 phosphorylation by N-methyl D-aspartic acid receptor activation in rat hippocampus.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Hippocampus; Kainic Acid; Male; Membrane Proteins; Microtubule Proteins; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nerve Growth Factors; Neurons; Pentylenetetrazole; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Time Factors | 2006 |
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Convulsants; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Hippocampus; Humans; Kainic Acid; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Phosphorylation; Seizures; tau Proteins | 2007 |
Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Hypnotics and Sedatives; Kainic Acid; Kindling, Neurologic; Male; Muscarinic Agonists; Pentylenetetrazole; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Rhodamine 123; Up-Regulation | 2007 |
Embryonic exposure to domoic Acid increases the susceptibility of zebrafish larvae to the chemical convulsant pentylenetetrazole.
Topics: Animals; Behavior, Animal; Convulsants; Embryo, Nonmammalian; Female; Kainic Acid; Larva; Male; Microinjections; Neuromuscular Depolarizing Agents; Pentylenetetrazole; Seizures; Swimming; Zebrafish | 2007 |
Effect of myo-inositol on convulsions induced by pentylenetetrazole and kainic acid in rats.
Topics: Animals; Anticonvulsants; Convulsants; Inositol; Kainic Acid; Pentylenetetrazole; Rats; Seizures | 2007 |
Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Mutation; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Reaction Time; Receptors, Somatostatin; Seizures | 2008 |
Seizure termination by acidosis depends on ASIC1a.
Topics: Acid Sensing Ion Channels; Acidosis; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Carbon Dioxide; Electroencephalography; Female; Hippocampus; Hydrogen-Ion Concentration; Interneurons; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Knockout; Nerve Tissue Proteins; Patch-Clamp Techniques; Pentylenetetrazole; Picrotoxin; Seizures; Sodium Channels; Time Factors | 2008 |
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.
Topics: Adult; Animals; Apoptosis; Convulsants; Cyclin D1; Disease Models, Animal; Epilepsy; Female; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurotoxins; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2008 |
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.
Topics: Analysis of Variance; Animals; Biophysics; Cell Count; Electric Stimulation; gamma-Aminobutyric Acid; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neural Pathways; Neuronal Plasticity; Neuropilin-2; Patch-Clamp Techniques; Pentylenetetrazole; Receptors, GABA; Seizures; Silver Staining; Synapses | 2009 |
Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Cardiovascular System; Central Nervous System Stimulants; Cerebrovascular Circulation; Convulsants; Electroshock; Hypnotics and Sedatives; Kainic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures; Sleep; Theophylline; Thyrotropin; Thyrotropin-Releasing Hormone | 2009 |
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Organoselenium Compounds; Pentylenetetrazole; Pilocarpine; Quinoxalines; Rats; Rats, Wistar; Seizures; Time Factors; Treatment Outcome | 2009 |
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Topics: Amygdala; Animals; Anticonvulsants; Binding Sites; Brain; Disease Models, Animal; Electroshock; Epilepsy; Kainic Acid; Kindling, Neurologic; Levetiracetam; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Pentylenetetrazole; Pharmacogenetics; Phenotype; Piracetam | 2009 |
Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electrophysiology; Electroshock; Ganglia, Spinal; Kainic Acid; Male; Mice; Motor Activity; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Thyrotropin-Releasing Hormone | 2009 |
Specificity of action of epileptogenic agents in diazepam-tolerant rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2009 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.
Topics: Animals; Cerebral Cortex; Convulsants; Crosses, Genetic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Female; Kainic Acid; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Pentylenetetrazole; Reaction Time; Seizures; Selection, Genetic | 2010 |
Seizure tests distinguish intermittent fasting from the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Blood Glucose; Caloric Restriction; Diet, Ketogenic; Electroshock; Fasting; Kainic Acid; Male; Mice; Pentylenetetrazole; Seizures | 2010 |
Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Antimetabolites; Blood Glucose; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Kainic Acid; Kindling, Neurologic; Male; Mice; Movement Disorders; Pentylenetetrazole; Rats; Seizures; Time Factors | 2010 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kainic Acid; Male; Mice; Motor Activity; Pentanones; Pentylenetetrazole; Seizures | 2010 |
Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats.
Topics: Action Potentials; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Neuromuscular Depolarizing Agents; Pentylenetetrazole; Rats; Rats, Sprague-Dawley | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rotarod Performance Test; Seizures | 2010 |
Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cell Death; Convulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diet; Dose-Response Relationship, Drug; Eating; Extinction, Psychological; Food-Drug Interactions; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Lactones; Male; Mice; Pentylenetetrazole; Seizures; Sulfones | 2011 |
Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats.
Topics: Animals; Benzothiadiazines; Convulsants; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Flowers; Heterocyclic Compounds, 4 or More Rings; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Seizures | 2011 |
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Topics: Animals; Antidepressive Agents; Biophysical Phenomena; Blood Glucose; Brain Infarction; CD8 Antigens; Cell Line, Transformed; Chlorocebus aethiops; Convulsants; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Eating; Electric Stimulation; Green Fluorescent Proteins; Hindlimb Suspension; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Potassium Channels; Potassium Channels, Tandem Pore Domain; Seizures; Swimming; Transfection | 2012 |
Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Interleukin-1beta; Kainic Acid; Lactones; Mice; Mice, Knockout; Pentylenetetrazole; Receptors, Interleukin-1; Seizures; Sulfones | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agonists; Kainic Acid; Lithium; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2012 |
The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Animals; Anticonvulsants; Blood Glucose; Blotting, Western; Cerebral Cortex; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Immunosuppressive Agents; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Pentylenetetrazole; Phosphorylation; Ribosomal Protein S6; Seizures; Sirolimus; Time Factors; TOR Serine-Threonine Kinases | 2012 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks Large Homolog 4 Protein; Excitatory Postsynaptic Potentials; Gene Knock-In Techniques; Guanylate Kinases; Hippocampus; Humans; Hypoxia; Kainic Acid; Membrane Proteins; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Phosphorylation; Receptors, AMPA; Seizures; Serine | 2012 |
Seizure protection by intrapulmonary delivery of midazolam in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Routes; Kainic Acid; Male; Mice; Midazolam; Pentylenetetrazole; Picrotoxin; Seizures | 2013 |
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
Topics: Animals; Anticonvulsants; Cells, Cultured; GABA Antagonists; Hippocampus; Kainic Acid; Male; Neurons; Pentylenetetrazole; Phosphatidylinositol Phosphates; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Status Epilepticus; Valproic Acid | 2014 |
Psychomotor seizure test, neurotoxicity and in vitro neuroprotection assay of some semicarbazone analogues.
Topics: Animals; Anticonvulsants; Cell Death; Coloring Agents; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Electroshock; Epilepsy, Complex Partial; Hippocampus; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Kainic Acid; Mice; Molecular Structure; Neuroprotective Agents; Pentylenetetrazole; Propidium; Semicarbazones | 2013 |
[Comparison of seizure induced by different drugs in ICR Mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Pilocarpine | 2013 |
Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
Topics: Adamantane; Amines; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intramuscular; Kainic Acid; Male; Memantine; N-Methylaspartate; Neuroprotective Agents; Pentylenetetrazole; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Analysis | 2014 |
Synthesis, anticonvulsant properties, and SAR analysis of differently substituted pyrrolidine-2,5-diones and piperidine-2,6-diones.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Drug Design; Electric Stimulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Molecular Structure; Neuroprotective Agents; Pentylenetetrazole; Piperidones; Seizures; Structure-Activity Relationship; Succinimides; Time Factors | 2014 |
Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood.
Topics: Animals; Animals, Newborn; Atrophy; Corpus Callosum; Diffusion Tensor Imaging; Disease Models, Animal; Female; Hippocampus; Hyperthermia, Induced; Kainic Acid; Kindling, Neurologic; Magnetic Resonance Imaging; Male; Neural Pathways; Pentylenetetrazole; Rats, Sprague-Dawley; Seizures | 2015 |
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Brain; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Female; Humans; Kainic Acid; Male; Malondialdehyde; Mice, Knockout; Mice, Transgenic; Oxidative Stress; Pentylenetetrazole; Presenilin-1; Seizures; Sodium-Coupled Vitamin C Transporters | 2015 |
Ultrastructural changes to rat hippocampus in pentylenetetrazol- and kainic acid-induced status epilepticus: A study using electron microscopy.
Topics: Animals; Astrocytes; Dendrites; Hippocampus; Kainic Acid; Male; Microscopy, Electron; Mitochondria; Neuroglia; Neurons; Pentylenetetrazole; Presynaptic Terminals; Rats; Status Epilepticus; Synapses; Synaptic Transmission | 2015 |
Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Apoptosis; CA3 Region, Hippocampal; Child; Child, Preschool; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Humans; Kainic Acid; Kindling, Neurologic; Male; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; RNA Interference; Seizures; Young Adult | 2015 |
Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Sparteine; Status Epilepticus | 2015 |
Metallothionein expression in the rat brain following KA and PTZ treatment.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Metallothionein; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Tyrosine | 2015 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Gliosis; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Protein Serine-Threonine Kinases; RNA, Messenger; Seizures; Signal Transduction | 2016 |
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Topics: Age Factors; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Mice; Microscopy, Immunoelectron; Nerve Tissue Proteins; Neuroglia; Neurons; Pentylenetetrazole; Seizures | 2016 |
Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Topics: Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Status Epilepticus; Time Factors | 2016 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nifedipine; Pentylenetetrazole; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley | 2017 |
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Injections, Intraventricular; Kainic Acid; Mice, Inbred C57BL; Pentylenetetrazole; Pilocarpine; Pyramidal Cells; Severity of Illness Index; Triterpenes; Zebrafish | 2017 |
CD36 Deficiency Suppresses Epileptic Seizures.
Topics: Action Potentials; Analysis of Variance; Animals; CD36 Antigens; Convulsants; Disease Models, Animal; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Seizures | 2017 |
Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy.
Topics: Adult; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy; Female; Growth Hormone-Releasing Hormone; Hippocampus; Humans; Kainic Acid; Male; Mice; Middle Aged; Neurons; Pentylenetetrazole; Receptors, GABA-A; Synapses; Young Adult | 2017 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Kainic Acid; Male; Malondialdehyde; Maze Learning; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Phenytoin; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Seizures; Sesquiterpenes; Status Epilepticus | 2018 |
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epilepsy; Humans; Kainic Acid; Mice; Pentylenetetrazole; Pilocarpine; Saccharomyces cerevisiae | 2018 |
Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Reaction Time; Receptor, Galanin, Type 2; Receptor, Galanin, Type 3; Seizures | 2018 |
Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Caspase 3; Convulsants; Disease Models, Animal; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Neuroprotective Agents; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Vitamin D | 2019 |
Expression of nuclear factor-erythroid 2-related factor 2 in rat brain following the administration of kainic acid and pentylenetetrazole.
Topics: Animals; Brain; Convulsants; Epilepsy; Kainic Acid; Male; NF-E2-Related Factor 2; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar | 2019 |
Immunohistochemical Study of Antioxidant Enzymes Regulated by Nrf2 in the Models of Epileptic Seizures (KA and PTZ).
Topics: Animals; Antioxidants; Behavior, Animal; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Models, Biological; NF-E2-Related Factor 2; Pentylenetetrazole; Rats, Wistar; Seizures | 2019 |
The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pentylenetetrazole; Seizures | 2019 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2 | 2020 |
Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Brain; Cognition; Epilepsy; Insulin; Kainic Acid; Male; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2020 |
Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration.
Topics: Animals; Convulsants; Female; Genetic Background; Interpersonal Relations; Kainic Acid; Male; Memory; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures; Species Specificity | 2019 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Flurothyl; Gene Expression; Gene Expression Profiling; Genetic Predisposition to Disease; Genotype; Hippocampus; Kainic Acid; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenotype; Quantitative Trait Loci; Seizures; Sudden Unexpected Death in Epilepsy; Whole Genome Sequencing | 2020 |
An optimized method for adult zebrafish brain-tissue dissociation that allows access mitochondrial function under healthy and epileptic conditions.
Topics: Animals; Brain; Cell Respiration; Disease Models, Animal; Energy Metabolism; Epilepsy; Female; Histocytological Preparation Techniques; Kainic Acid; Male; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Pentylenetetrazole; Tissue Preservation; Zebrafish | 2021 |
Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure.
Topics: Animals; Cerebral Cortex; Hippocampus; Iron; Kainic Acid; Male; Malonates; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seizures; Status Epilepticus; Succinic Acid | 2021 |
Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Emergencies; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Mice; Pentylenetetrazole; Seizures; Status Epilepticus | 2021 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanosine Monophosphate; Kainic Acid; Lamiaceae; Methylene Blue; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Picrotoxin; Plant Extracts; Receptors, GABA-A; Seizures; Soluble Guanylyl Cyclase; Spasm | 2022 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2022 |
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Topics: Animals; Apelin; Endocytosis; Kainic Acid; Mice; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures; Synaptic Transmission | 2023 |
Seizure-induced increase in microglial cell population in the developing zebrafish brain.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Microglia; Pentylenetetrazole; Seizures; Zebrafish | 2023 |