pentylenetetrazole has been researched along with gamma-aminobutyric acid in 301 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 110 (36.54) | 18.7374 |
| 1990's | 52 (17.28) | 18.2507 |
| 2000's | 69 (22.92) | 29.6817 |
| 2010's | 51 (16.94) | 24.3611 |
| 2020's | 19 (6.31) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Javid, MJ; Stone, WE | 1 |
| Bernardo, K; Keenan, L; Koopowitz, H | 1 |
| Beer, B; Coupet, J; Greenblatt, EN; Klepner, CA; Lippa, AS | 1 |
| Bergman, A; Höglund, L; Hulth, L; Möller, L | 1 |
| Costa, E; Guidotti, A; Mao, CC; Suria, A | 1 |
| Dinnedahl, V; Gumulka, SW; Opmeer, FA; Schönhöfer, PS | 1 |
| Atanassova-shopova, S; Lazarova, MB; Roussinov, KS | 1 |
| Lazarova, MB; Roussinov, KS | 1 |
| Dinnendahl, V; Gumulka, SW; Schönhöfer, PS | 1 |
| Matthews, WD; McCafferty, GP | 1 |
| Costa, E; Guidotti, A; Mao, CC | 1 |
| Davidoff, RA; Hackman, JC | 1 |
| Stone, WE | 1 |
| Frey, HH; Löscher, W; Popp, C | 1 |
| Reiffenstein, RJ | 1 |
| Franco, S; Schlosser, W | 1 |
| Ackermann, RF; Engel, J; Myslobodsky, MS | 1 |
| Bloch-Tardy, M; Gonnard, P; Gonzalez Rios, F; Wegmann, R | 1 |
| Barker, JL; Macdonald, RL | 1 |
| Lippa, AS; Regan, B | 1 |
| Lazarova, M; Roussinov, K | 1 |
| Greenlee, D; Olsen, RW; Ticku, MK; Van Ness, PC | 1 |
| Andén, NE; Wachtel, H | 1 |
| Simmonds, MA | 1 |
| Chujo, T | 1 |
| Bianchi, M; Galzigna, L; Garbin, L; Marzotto, A | 1 |
| Bhaskar Rao, A; Joseph, PK; Rajan, R; Ramakrishna Rao, P; Ramakrishnan, S | 1 |
| Fukuda, T; Igisu, H; Izumi, K | 1 |
| Izumi, K | 1 |
| Pellmar, TC; Wilson, WA | 1 |
| Peesker, SJ; Wood, JD | 1 |
| Dobkin, J; Lichtshtein, D | 1 |
| Liu, CC; Nichols, AC; Snead, OC | 1 |
| Daval, JL; el Hamdi, G; Nehlig, A; Pereira de Vasconcelos, A; Werck, MC | 1 |
| Mehta, AK; Mhatre, M; Ticku, MK | 1 |
| Fink-Jensen, A; Hansen, L; Judge, ME; Nielsen, PG; Suzdak, PD; Swedberg, MD | 1 |
| Andersen, KE; Frederiksen, K; Knutsen, LJ; Nielsen, EB; Suzdak, PD; Sørensen, PO | 1 |
| Corda, MG; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M | 1 |
| Enna, SJ; Ferkany, JW; Karbon, EW | 1 |
| Browne, SE; Pertwee, RG; Ross, TM; Stretton, CD | 1 |
| Abed, WT | 2 |
| Casara, P; Knödgen, B; Sarhan, S; Seiler, N | 1 |
| Araki, H; Sano, M; Shimada, C; Tanaka, S | 1 |
| Hasegawa, T; Hashimoto, H; Nakajima, T; Nakao, J; Noto, T | 1 |
| Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD | 1 |
| Fredow, G; Löscher, W | 1 |
| Arnoldi, A; Bonsignori, A; Melloni, P; Merlini, L; Quadri, ML; Varasi, M | 1 |
| Coulter, DA; Huguenard, JR; Prince, DA | 2 |
| De Deyn, PP; MacDonald, RL; Marescau, B | 1 |
| Ferrendelli, JA; Miller, JW | 1 |
| Sedlácek, J | 4 |
| Gonsalves, SF; Harbaugh, RE; Krogsgaard-Larsen, P; Schousboe, A; Twitchell, B | 1 |
| Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M | 1 |
| Beal, MF; Männistö, PT; Pitkänen, A; Riekkinen, PJ; Sirviö, J; Swartz, KJ | 1 |
| Nagaya, H; Negishi, N; Okada, R | 1 |
| Rosenberg, HC; Tietz, EI; Zhang, H | 1 |
| Krsiak, M | 1 |
| Hara, S; Morioka, S; Satoh, K; Yanagihara, S | 1 |
| Leidenheimer, NJ; Schechter, MD | 1 |
| Harris, C; Lal, H | 1 |
| Drejer, J; Honoré, T; Jensen, LH; Petersen, EN | 1 |
| Kent, AP; Webster, RA | 1 |
| Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N | 1 |
| Maksay, G; Ticku, MK | 1 |
| Chang, YF; Myslinski, NR | 1 |
| Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS | 1 |
| Lloyd, KG | 1 |
| Chweh, AY; Lin-Michell, E; Swinyard, EA | 1 |
| Fukuda, H; Goto, M; Morishita, S | 1 |
| Chiu, TH; Ito, M; Rosenberg, HC | 1 |
| Little, HJ; Nutt, DJ; Taylor, SC | 1 |
| Vamvakidès, A | 1 |
| Kolokouris, N; Vamvakidès, A | 1 |
| Kantarev, N; Parisheva, Z; Toreva, D | 1 |
| Lee, M; Netzeband, JG; Strahlendorf, HK; Strahlendorf, JC | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Bennett, DB; Comereski, CR; Williams, PD | 1 |
| Lin, WC; Watanabe, K; Yano, S | 1 |
| Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M | 1 |
| Kraras, CM; Lathers, CM; Tumer, N | 1 |
| Rock, DM; Taylor, CP | 1 |
| Alpern, HP; McIntyre, TD | 1 |
| Keane, PE; Morre, M | 1 |
| Löscher, W | 4 |
| Asai, M; Linares, G; Massarini, A; Talavera, E; Vindrola, O; Zubieta, M | 1 |
| Higashio, T; Inukai, T; Nakao, K | 1 |
| Chalabian, ZhA | 1 |
| Owasoyo, JO; Walker, CA | 1 |
| Ramakrishnan, S; Rao, AB; Subrahmanyam, K | 1 |
| Brown, CL; Martin, IL | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Dunn, R; Fielding, S; Kruse, H; Lal, H; Shearman, GT; Theurer, K | 1 |
| Horisaka, K | 1 |
| Woodbury, DM | 1 |
| Kryzhanovskiĭ, GN; Nikushkin, EV; Shandra, AA | 1 |
| Morag, M; Myslobodsky, MS | 1 |
| Blavet, N; DeFeudis, FV | 1 |
| Bymaster, FP; Lacefield, WB; Rathbun, RC; Wong, DT | 1 |
| Abbracchio, MP; Balduini, W; Cattabeni, F; Coen, E; Lombardelli, G; Peruzzi, G | 1 |
| Lathers, CM; Suter, LE | 1 |
| Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J | 1 |
| Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G | 1 |
| Crider, AM; Hinko, CN; Seibert, K | 1 |
| Barris, D; Cordi, A; Roba, J; van Dorsser, W | 1 |
| File, SE; Simmonds, MA | 1 |
| Ciesielski, L; Klein, M; Mandel, P; Simler, S | 1 |
| Croucher, MJ; Krogsgaard-Larsen, P; Meldrum, BS | 1 |
| Kalichman, MW | 1 |
| McCandless, DM; Schwartzenburg, FC | 1 |
| Bowdler, JM; Cowen, PJ; Green, AR; Sant, K | 1 |
| Gale, K; Iadarola, MJ | 1 |
| Benedito, MA; Leite, JR | 1 |
| Kleinrok, Z; Lazarova, M; Rajtar, G; Roussinov, K | 1 |
| Joseph, PK; Ramakrishnan, S; Rao, AB; Rao, PR | 1 |
| Bloch-Tardy, M; Gonnard, P; Gonzalez Rios, FU; Wegmann, R | 1 |
| Frey, HH; Löscher, W | 1 |
| Lal, H; Shearman, GT | 1 |
| Erickson, CK | 1 |
| Koff, JM; Miller, LG | 1 |
| Sayin, U; Timmerman, W; Westerink, BH | 1 |
| Georgiev, VP; Kambourova, TS; Lazarova, MB | 1 |
| Day, IP; Goudie, J; Nishiki, K; Williams, PD | 1 |
| Bolster, B; Dakshinamurti, K; Sharma, SK | 1 |
| Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliand, M; Mineo, A; Sabatino, M | 1 |
| Kokate, TG; Rogawski, MA; Svensson, BE | 1 |
| Pomés, A; Rodríguez-Farré, E; Suñol, C | 1 |
| Getova, DP; Maslarova, JE; Nikolov, RK; Semkova, IS | 1 |
| Amabeoku, G; Bwakura, E; Chikuni, O | 1 |
| Altug, T; Cengiz, S; Sayin, U | 1 |
| Arai, H; Imai, K; Itagaki, Y; Kodaka, R; Nagai, T; Okada, S; Ono, J; Suzuki, Y; Tanaka, J | 1 |
| Bingmann, D; Bonnet, U | 1 |
| Moshé, SL; Velísek, L; Velísková, J | 1 |
| Gurin, VN; Rózsa, KS; Rubakhin, SS; Szücs, A | 1 |
| Avenet, P; Depoortere, H; Granger, P; Itier, V; Perrault, G; Scatton, B | 1 |
| Bottlaender, M; Brouillet, E; Fournier, D; Fuseau, C; Mazière, M; Schmid, L | 1 |
| Ito, M; Kishi, K; Sejima, H; Shiraishi, H; Tsuda, H | 1 |
| Brown, SD; Skeen, GA; White, HS; Wolf, HH; Woodhead, JH | 2 |
| Bashkatova, VG; Mikoian, VD; Narkevich, VB; Raevskiĭ, KS; Vanin, AF; Vitskova, GIu | 1 |
| Haugvicová, R; Mares, P | 1 |
| George, B; Kulkarni, SK | 1 |
| Kozuchová, A; Mares, P; Stanková, L | 1 |
| Haugvicová, R; Kubová, H; Mares, P | 1 |
| Anseloni, VZ; Brandão, ML | 1 |
| Hattori, Y; Hayashi, Y; Morizumi, Y; Tanaka, J | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Walsh, LA; Zhao, TJ | 1 |
| Easton, A; Gale, K; Walker, BR | 1 |
| Boehrer, A; Brailowsky, S; Marescaux, C; Montiel, T; Vergnes, M | 1 |
| Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS | 1 |
| Almeida, D; Arango, I; Brailowsky, S; Calixto, E; Casasola, C; Montiel, T | 1 |
| Bac, P; Delcourt, P; Herrenknecht, C; Maurois, P; Stables, JP; Vamecq, J | 1 |
| Dziuba, J; Kleinrok, Z; Saczonek, J; Sieklucka-Dziuba, M | 1 |
| Dibas, MI; Dillon, GH | 1 |
| Arikan, K; Coskun, T; Guvener, B; Oran, O | 1 |
| Abel, MS; Kohli, N | 1 |
| Chopde, CT; Deshmukh, VK; Kasture, VS | 2 |
| Beekman, M; Carter, RB; Dijkstra, D; Gasior, M; Ungard, JT; Witkin, JM | 1 |
| Dalby, NO | 1 |
| Ha, JH; Ha, JS; Huh, K; Kim, JA; Kim, JS; Lee, DU; Lee, JT; Yong, CS | 1 |
| Gutiérrez, R | 1 |
| Frye, CA; Harney, JP; Rhodes, ME; Walf, AA | 1 |
| He, X; Li, W; Ruan, X; Wang, W; Zhang, L | 1 |
| Hamann, M; Richter, A | 1 |
| Bruins Slot, LA; Colpaert, FC; Koek, W; Ribet, JP; Tarayre, JP | 1 |
| Assandri, R; Crestani, F; Martin, JR; Rudolph, U; Täuber, M | 1 |
| Tan, CY; Wainman, D; Weaver, DF | 1 |
| Armijo, JA; Bravo, J; Cuadrado, A | 1 |
| Aznavour, N; Carmant, L; Descarries, L; Mamer, OA; Meilleur, S; Psarropoulou, C | 1 |
| Dahl, CB; Eloqayli, H; Götestam, KG; Hadidi, H; Sonnewald, U; Unsgård, G | 1 |
| Goncharenko, NV; Pankrat'ev, DV; Talalaenko, AN | 1 |
| Amat, G; Armijo, JA; Cuadrado, A | 1 |
| LIGHTOWLER, JE; MACLEAN, JA | 1 |
| CARVAJAL, G; MASSIEU, G; RUSSEK, M; TAPIA, R | 1 |
| BHARGAVA, KP; BHATTACHARYA, SS; KISHOR, K; SAXENA, PN | 1 |
| Alhonen, L; Gröhn, OH; Jänne, J; Kaasinen, SK; Keinänen, TA | 1 |
| Bureau, Y; McIntyre, DC; Racine, RJ; Steingart, M | 1 |
| Ayala Guerrero, F; Barragán Mejía, G; Calderón Guzmán, D; Espitia Vázquez, I; Juárez Olguín, H; Labra Ruiz, N; Rodríguez Pérez, R; Santamaria del Angel, D | 1 |
| Czuczwar, SJ; Luszczki, JJ | 2 |
| Celio, MR; Henzi, T; Potier, MC; Schwaller, B; Silveira, DC; Tandon, P; Tetko, IV; Villa, AE; Vreugdenhil, M | 1 |
| Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN | 1 |
| Acosta, GB; Baratti, CM; Blake, MG; Boccia, MM | 1 |
| Chopde, CT; Hirani, K; Mittal, N; Ugale, RR | 1 |
| Bolvig, T; Clausen, RP; Falch, E; Frølund, B; Hansen, SL; Krogsgaard-Larsen, P; Larsson, OM; Perregaard, J; Petersen, G; Sarup, A; Schousboe, A; Slough, S; Watson, WP; White, HS | 1 |
| Gutiérrez, R; Vivar, C | 1 |
| Armijo, JA; Cuadrado, A | 1 |
| Dos Santos, RG; Dotsikas, I; Felix, R; Kolocouris, N; Papadopoulou-Daifoti, Z; Papanastasiou, I; Sandoval, A; Vamvakides, A; Zoidis, G | 1 |
| Brickley, S; Chiu, CS; Cull-Candy, S; Jensen, K; Lester, HA; Mckinney, S; Mody, I; Southwell, A | 1 |
| Aloe, L; Costa, N; Tirassa, P | 1 |
| Chen, L; Gao, MM; Liao, WP; Su, T; Sun, WW; Yang, SQ; Yi, YH | 1 |
| Frye, CA; Rhodes, ME | 1 |
| Bhardwaj, A; Keyl, PM; Mirski, MA; Sherman, DL; Zhang, N; Ziai, WC | 1 |
| Brito, VB; Fachinetto, R; Folmer, V; Nogueira, CW; Puntel, GO; Rocha, JB; Soares, JC; Zeni, G | 1 |
| Bhattacharyya, D; Dey, S; Mandal, TK; Manna, S | 1 |
| Bao, Y; Li, CZ; Xie, W; Yu, LJ | 1 |
| Caldwell, GA; Caldwell, KA; Locke, CJ; Schwarz, EM; Williams, SN | 1 |
| Kato, N; Murata, M | 1 |
| Calpona, PR; Citraro, R; Costa, N; Cuzzocrea, S; De Luca, G; De Sarro, G; Di Giorgio, RM; Di Paola, ED; Macaione, S; Russo, E | 1 |
| Enrique Jiménez-Ferrer, J; Gutiérrez, C; Herrera-Ruiz, M; León, I; Mirón, G; Tortoriello, J | 1 |
| Pericić, D; Strac, DS; Vlainić, J | 1 |
| Flórez, J; Martínez-Cué, C; Rueda, N | 1 |
| Nassiri-Asl, M; Shariati-Rad, S; Zamansoltani, F | 1 |
| Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ | 1 |
| Prakash, T; Rao, NR; Swamy, AH | 1 |
| Anzini, M; Betti, L; Braile, C; Cappelli, A; Ghelardini, C; Giannaccini, G; Giorgi, G; Ian Fryer, R; Limongelli, V; Lucacchini, A; Makovec, F; Marinelli, L; Norcini, M; Novellino, E; Valenti, S; Vomero, S | 1 |
| Bachstetter, A; Barnes, GN; Blalock, EM; Gant, JC; Hauser, KF; Kotick, J; Li, Y; Mervis, R; Schauwecker, PE; Smith, GM; Thibault, O; Yang, J | 1 |
| Kumar, M; Rehni, AK; Singh, I | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Berkovic, SF; Chiu, C; Davies, PJ; Jones, MV; Koukoulas, I; Petrou, S; Reid, CA; Single, FN; Sprengel, R; Tan, HO; Tan, SS | 1 |
| Alonso-Cortes, D; del Carmen Gutiérrez, M; Estrada-Soto, S; Herrera-Ruiz, M; León-Rivera, I; Mirón-López, G; Molina-Salinas, GM; Navarrete-Vázquez, G; Ríos, MY; Said-Fernández, S | 1 |
| Fernandez, F; Heller, HC; Hwang, CE; Ruby, NF; Sapolsky, R; Wessells, C; Zhang, P | 1 |
| Fukuma, G; Hase, K; Hirose, S; Kaneko, S; Kijima, H; Kishi, A; Kojima, T; Mitsudome, A; Miura, Y; Mori, F; Ohno, H; Okada, M; Saito, R; Sato, A; Takahara, T; Takano, Y; Tomiyama, M; Ueno, S; Wakabayashi, K; Yoshida, S; Zhu, G | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M | 1 |
| Angst, MJ; Ferrandon, A; François, J; Koning, E; Nehlig, A; Sandner, G | 1 |
| Bidziński, A; Hamed, A; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Sobolewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Wisłowska-Stanek, A | 1 |
| de Aquino Neto, MR; de Lavor, EP; de Sousa, DP; de Sousa, FC; de Sousa, HL; de Vasconcelos, PF; Macêdo, DS; Moura, BA; Silva, MA; Silva, MI; Vasconcelos, SM | 1 |
| Beleboni, RO; França, SC; Marques, MO; Neto, AC; Netto, JC; Pereira, AM; Pereira, PS; Taleb-Contini, SH | 1 |
| Canty, AJ; Dietze, J; Enomoto, H; Harvey, M; Ibáñez, CF; Milbrandt, J | 1 |
| Berry, KP; Caldwell, GA; Caldwell, KA; Kautu, BB; Lee, SK; Locke, CJ | 1 |
| Achim, CL; Bae, MH; Bissonette, GB; Depireux, DA; Mars, WM; Michalopoulos, GK; Powell, EM | 1 |
| Mares, P | 1 |
| Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM | 1 |
| Elsas, SM; Gregory, WL; Mohr, C; Pfankuch, T; Raber, J; Rossi, DJ; Seeley, CA; Soumyanath, A; White, G | 1 |
| Al-Tel, TH; Alsalahat, IM; El-Shorbagi, AN; Semreen, MH | 1 |
| González-Ramírez, M; González-Trujano, ME; Orozco-Suarez, S; Razo-Juárez, LI; Salgado-Ceballos, H; Sauer-Ramírez, JL | 1 |
| Paz, C; Retana-Márquez, S; Rubio, C; Rubio-Osornio, M; Verónica Custodio, ML | 1 |
| Desai, PV; Therisa, KK | 1 |
| Abraham, C; Bai, L; Leube, RE | 1 |
| Gopal, K; Gross, GW; Lukas, TJ; Moore, EJ; Wu, C | 1 |
| Chebib, M; Gavande, N; Hanrahan, JR; Johnston, GA; Karim, N; Wellendorph, P | 1 |
| Dabbish, NS; Raizen, DM | 1 |
| Goel, A; Goel, R; Kumar, Y | 1 |
| Abbasi, E; Nassiri-Asl, M; Shafeei, M; Sheikhi, M | 1 |
| Czuczwar, SJ; Luszczki, JJ; Nieoczym, D; Socała, K; Wlaź, P | 1 |
| Chang, WN; Du, HC; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH; Safo, MK; Sung, SY | 1 |
| Chen, Z; Fan, YY; Fang, Q; He, P; Hu, WW; Ohtsu, H; Xu, TL; Xu, ZH; Yan, HJ; Yang, Y; Zhang, CY; Zhang, XN; Zhong, K | 1 |
| Dai, K; Hoshikawa, M; Niwa, O; Okada, M; Saito, H; Suzuki, N; Yamamura, S | 1 |
| Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM | 1 |
| Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K | 1 |
| Banote, RK; Chatti, K; Chennubhotla, KS; Koutarapu, S; Kulkarni, P | 1 |
| Mohan, CG; Shylaja, H; Sunil, V; Viswanatha, GL; Yuvaraj, HC | 1 |
| Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM | 1 |
| Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E | 1 |
| Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM | 1 |
| Ahuja, P; Arya, SK; Malik, S; Siddiqui, N | 1 |
| Jiang, Y; Xiang, J | 1 |
| Cui, R; Dong, X; Li, B; Liu, C; Lv, J; Shao, D; Song, Y; Sun, Z; Wang, L; Wang, P; Zhang, X; Zhao, J; Zhou, Y | 1 |
| Filipek, B; Höfner, GC; Kowalczyk, P; Kulig, K; Mucha, M; Podkowa, A; Rapacz, A; Sałat, K; Wanner, KT | 1 |
| Jenita, JL; Lavanya, Y; Priyadarshini, SR; Ramasamy, M; Wilson, B | 1 |
| Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK | 1 |
| Elahdadi Salmani, M; Goudarzi, E; Goudarzi, I; Lashkarbolouki, T | 1 |
| Çengelli Ünel, Ç; Erol, K; Kırımlıoğlu, GY; Yazan, Y | 1 |
| Koshal, P; Kumar, P | 1 |
| Gernert, M; Gey, L; Löscher, W | 1 |
| Akhtar, MJ; Ali, Z; Khan, AA; Siddiqui, N; Yar, MS | 1 |
| Coppola, G; Iovane, V; Monda, M; Operto, FF; Pisano, S; Stoddard, M; Viggiano, A | 1 |
| Amiri, S; Dehdashtian, A; Dehpour, AR; Ghasemi, M; Ostadhadi, S; Sheikhi, M; Shirzadian, A | 1 |
| Ahmad, N; Akbar, S; Ali, G; Fawad, K; Karim, N; Mahmood, W; Shahid, M; Subhan, F | 1 |
| Kumar, M; Kumar, P | 1 |
| Prasad, NBL; Venkataranganna, MV; Viswanatha, GL | 1 |
| Ackley, MA; Althaus, AL; Doherty, JJ; Hammond, RS; Maciag, C; Martinez Botella, G; Robichaud, AJ; Salituro, FG | 1 |
| Arellano-García, J; Gutiérrez, MDC; Herrera-Ruiz, M; León-Rivera, I; Mundo, J; Perea-Arango, I; Villeda-Hernández, J | 1 |
| Barbieri Caus, L; Calcagnotto, ME; Ganzella, M; Gomes de Souza, DO; Goodman, S; Junges, B; Koeller, DM; Loureiro, S; Meier, L; Umpierrez Amaral, A; Vendramin Pasquetti, M; Wajner, M; Woontner, M | 1 |
| Ambassa, ARM; Dzeufiet, PDD; Kouamou, ALN; Menanga, JR; Taiwe, GS; Tchoya, TB | 1 |
| Amin, F; Arain, FM; Chand, P; Dar, AH; Haider, G; Khan, F; Mitha, R; Osama, K; Tharwani, A | 1 |
| Bi, Y; Ding, L; Gao, W; Ye, M; Zhu, W | 1 |
| Ashour, RH; El-Beltagi, HM; Hamada, NM; Shalaby, AA | 1 |
| Backofen-Wehrhahn, B; Bröer, S; Gernert, M; Gey, L; Handreck, A; Löscher, W; Niemann, H; Petersen, B; Scharrenbroich, J; Schiff, M; Staege, S; Stanslowsky, N; Wegner, F; Weißing, M | 1 |
| Choo, BKM; Johan Arief, MFB; Kumari, Y; Kundap, UP; Othman, I; Shaikh, MF; Wong, CP; Yap, JL | 1 |
| Reyes, GC; Vega Díaz, F; Vega Rasgado, LA | 1 |
| Barzroodi Pour, M; Bayat, M; Eftekharzadeh, M; Golab, F; Karimzadeh, F; Katebi, M; Soleimani, M | 1 |
| Aghamiri, H; Asgarpanah, J; Shafaroodi, H | 1 |
| Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ | 1 |
| Bosma, M; Braun, KPJ; Inserra, M; Koeleman, BPC; Rivara, M; Rook, MB; Singh, S; van 't Slot, RH; Verhoeven-Duif, NM; Vetter, I; Volkers, L; Weuring, WJ | 1 |
| Kishore, DV; Prasad, NBL; Shylaja, H; Venkataranganna, MV; Viswanatha, GL | 1 |
| Akagawa, K; Fujiwara, T; Kofuji, T; Mishima, T; Saito, A; Terao, Y | 1 |
| Ahn, JH; Ahn, SH; Bae, MA; Cho, SH; Hwang, KS; Kan, H; Kim, SS; Lee, BH; Shin, DS; Son, Y; Yang, JY | 1 |
| Bahramnejad, E; Dehpour, AR; Jahanbani, R; Moosavi-Movahedi, AA; Rahimi, N; Shafaroodi, H; Sheibani, N; Vahdati, K | 1 |
| Deking, LS; During, MJ; Feja, M; Gernert, M; Kaczmarek, E; Meller, S; Silverman, RB | 1 |
| Ergul, M; Gumus, E; Ozdemir, E; Sahin, B; Taskiran, AS | 1 |
| Chen, H; Cheung, AK; Lee, SMY; Qiu, J; Siu, SWI; Wong, CTT | 1 |
| Chen, Y; Li, R; Lin, L; Liu, L; Mei, R; Wen, Y; Zhang, F; Zhang, G; Zhang, P | 1 |
| Adegoke Salami, H; Muhammad Bello, A; Musa Chiroma, S; Samaila Malgwi, I | 1 |
| Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S | 1 |
| Chen, YM; Li, R; Lin, L; Mei, R; Zhang, FL; Zhang, P; Zhang, XL; Zhou, JY | 1 |
| Bila, RB; Bouvourne, P; Foyet, HS; Jugha, VT; Mambou, AHMY; Nkwingwa, BK; Taiwe, GS; Wado, EK | 1 |
| Arora, S; Kaur, S; Kumar, N; Rajput, A; Sharma, P; Singh Bedi, PM; Singh, B; Singh, H; Singh, S; Singh, T | 1 |
| Adassi, BM; Ateufack, G; Foutsop, AF; Kom, TD; Ngoupaye, GT; Noungoua, CM; Petsou, A; Yassi, FB | 1 |
| Ciltas, AC; Güneş, H; Toy, CE; Yaprak, M | 1 |
| He, X; Liu, Y; Xie, Y; Yang, Y; Yuan, X | 1 |
5 review(s) available for pentylenetetrazole and gamma-aminobutyric acid
| Article | Year |
|---|---|
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra | 1975 |
Epilepsy and the GABA-hypothesis a brief review and some examples.
Topics: Animals; Brain; Carbolines; Convulsants; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Guanidines; Humans; Mice; Pentylenetetrazole; Pyrazoles; Receptors, GABA-A | 1990 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Nerve Endings; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 1986 |
Modulation of presynaptic gamma aminobutyric acid release by prostaglandin E2: explanation for epileptogenic activity and dysfunction in autonomic cardiac neural discharge leading to arrhythmias?
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Cats; Dinoprostone; Epilepsy; gamma-Aminobutyric Acid; Heart; Humans; In Vitro Techniques; Models, Biological; Pentylenetetrazole; Prostaglandins E; Rabbits; Rats; Status Epilepticus | 1984 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Epilepsy, Reflex; Flurothyl; gamma-Aminobutyric Acid; Humans; Kainic Acid; Kindling, Neurologic; Muscarinic Agonists; Papio; Penicillins; Pentylenetetrazole; Pilocarpine; Tetanus Toxin; Zinc Compounds | 2010 |
296 other study(ies) available for pentylenetetrazole and gamma-aminobutyric acid
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Benzodiazepines and phenobarbital as antagonists of dissimilar chemical convulsants.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Picrotoxin; Therapeutic Equivalency | 1978 |
Primitive nervous systems: action of aminergic drugs and blocking agents on activity in the ventral nerve cord of the flatworm Notoplana acticola.
Topics: Animals; Bicuculline; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Neurons; Neurotransmitter Agents; Pentylenetetrazole; Peripheral Nerves; Picrotoxin; Platyhelminths | 1979 |
A synthetic non-benzodiazepine ligand for benzodiazepine receptors: a probe for investigating neuronal substrates of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Body Temperature; Conflict, Psychological; gamma-Aminobutyric Acid; Glycine; Humans; Ligands; Male; Mice; Motor Activity; Neurons; Pentylenetetrazole; Pyridazines; Rats; Receptors, Drug; Seizures | 1979 |
Convulsive properties of lindane, lindane metabolites, and the lindane isomer alpha-hexachlorocyclohexane: effects on the convulsive threshold for pentylenetetrazol and the brain content of gamma-aminobutyric acid (GABA) in the mouse.
Topics: Animals; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Mice; Pentylenetetrazole; Seizures | 1978 |
Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain.
Topics: Animals; Atropine; Brain; Brain Chemistry; Convulsants; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Harmaline; Male; Mice; Oxotremorine; Pentobarbital; Pentylenetetrazole; Picrotoxin; Tremor | 1976 |
On certain relationships between gamma-aminobutyric acid (GABA) and adrenergic mechanisms in convulsive-seizure reaction.
Topics: Aminobutyrates; Animals; Ditiocarb; Electroshock; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Methyltyrosines; Mice; Pentylenetetrazole; Seizures; Strychnine; Sympathetic Nervous System | 1976 |
On certain relationships between gamma-aminobutyric acid (GABA) and dopaminergic agents in pentylenetetrazol convulsions.
Topics: Amantadine; Animals; Apomorphine; Dextroamphetamine; Ditiocarb; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Haloperidol; Levodopa; Male; Mice; Pentylenetetrazole; Seizures | 1978 |
Baclofen and cerebellar cyclic GMP levels in mice.
Topics: Animals; Arecoline; Baclofen; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin | 1979 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Synaptic Transmission | 1979 |
Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoniazid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Strychnine | 1975 |
Pentylenetetrazol and reflex activity of isolated frog spinal cord.
Topics: Amino Acids; Animals; Anura; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Motor Neurons; Neurons, Efferent; Pentylenetetrazole; Rana pipiens; Reflex; Reflex, Monosynaptic; Spinal Cord | 1978 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid | 1977 |
Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice.
Topics: Animals; Atropine; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nipecotic Acids; Parasympathetic Nervous System; Pentylenetetrazole; Seizures | 1979 |
Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex.
Topics: Animals; Cats; Cerebral Cortex; Decerebrate State; Electric Stimulation; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Seizures | 1979 |
Reduction of gamma-aminobutyric acid (GABA)-mediated transmission by a convulsant benzodiazepine.
Topics: Animals; Benzodiazepinones; Bicuculline; Cats; Convulsants; Female; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pentylenetetrazole; Picrotoxin; Reflex; Spinal Cord; Strychnine | 1979 |
Effects of gamma-acetylenic GABA and gamma-vinyl GABA on metrazol-activated, and kindled seizures.
Topics: Alkynes; Aminocaproates; Animals; Arousal; Drug Interactions; Electric Stimulation; Electroencephalography; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Seizures | 1979 |
[Modifications of the synaptosomal level of gamma-aminobutyric acid during convulsions provoked by pentamethylenetetrazol (author's transl)].
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Pentylenetetrazole; Rats; Seizures; Synaptosomes | 1979 |
Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action.
Topics: Amino Acids; Aminobutyrates; Animals; Bicuculline; Convulsants; Culture Techniques; gamma-Aminobutyric Acid; Iontophoresis; Mice; Neural Inhibition; Neurons; Penicillins; Pentylenetetrazole; Picrotoxin; Spinal Cord | 1978 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Male; Mice; Pentylenetetrazole; Seizures; Strychnine | 1977 |
On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in pentylenetetrazol convulsions.
Topics: Aminobutyrates; Animals; Arecoline; gamma-Aminobutyric Acid; Male; Mice; Parasympathetic Nervous System; Parasympatholytics; Pentylenetetrazole; Physostigmine; Salicylates; Scopolamine; Seizures | 1977 |
Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro.
Topics: Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Imipramine; In Vitro Techniques; Male; Mice; Penicillin G; Pentylenetetrazole; Picrotoxin; Receptors, Drug; Synaptosomes | 1978 |
Motor activity of rats following intracerebral injections of drugs influencing GABA mechanisms.
Topics: Aminobutyrates; Animals; Apomorphine; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Habituation, Psychophysiologic; Hydroxybutyrates; Injections; Male; Motor Activity; Nucleus Accumbens; Pentylenetetrazole; Picrotoxin; Rats; Reserpine; Strychnine | 1978 |
Presynaptic actions of gamma-aminobutyric acid and some antagonists in a slice preparation of cuneate nucleus.
Topics: Aminobutyrates; Animals; Bemegride; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; In Vitro Techniques; Male; Medulla Oblongata; Neuromuscular Depolarizing Agents; Pentylenetetrazole; Potassium; Rats; Strychnine | 1978 |
Neuronal mechanisms of the late N-wave induced in vitro in thin sections of the olfactory cortex of rats.
Topics: Action Potentials; Animals; Dopamine; gamma-Aminobutyric Acid; In Vitro Techniques; Limbic System; Olfactory Pathways; Penicillins; Pentylenetetrazole; Rats; Temperature | 1978 |
Properties of two derivatives of gamma-aminobutyric acid (GABA) capable of abolishing Cardiazol- and bicuculline-induced convulsions in the rat.
Topics: Animals; Bicuculline; Brain; Chemical Phenomena; Chemistry, Physical; Female; gamma-Aminobutyric Acid; Isoquinolines; Male; Mitochondria; Pentylenetetrazole; Rats; Seizures | 1978 |
Glutamate-gamma-aminobutyric acid metabolism in cerebral cortex of rat in leptazol-induced convulsions.
Topics: Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamine; Male; Pentylenetetrazole; Rats; Seizures | 1978 |
Effects of edetate on seizure suppressing actions of taurine and GABA.
Topics: Aminobutyrates; Animals; Anticonvulsants; Calcium; Dose-Response Relationship, Drug; Edetic Acid; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Premedication; Seizures; Taurine | 1975 |
[Suppression of seizures by taurine - effects of edetate on actions of taurine and GABA (author's transl)].
Topics: Aminobutyrates; Animals; Anticonvulsants; Edetic Acid; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Seizures; Taurine | 1975 |
Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.
Topics: Acetylcholine; Animals; Chlorides; Dopamine; Electric Conductivity; gamma-Aminobutyric Acid; Membrane Potentials; Mollusca; Pentylenetetrazole; Potassium; Serotonin; Sodium; Synaptic Membranes | 1977 |
The anticonvulsant action of GABA-elevating agents: a re-evaluation.
Topics: Allyl Compounds; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hydrazines; Hydroxylamines; Hyperbaric Oxygenation; Isoniazid; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Stimulation, Chemical; Time Factors | 1975 |
Reduction of gamma-aminobutyric acid level in the cat cerebral cortex by afferent electrical stimulation.
Topics: Aminobutyrates; Animals; Brachial Plexus; Cats; Cerebral Cortex; Electric Stimulation; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Picrotoxin | 1976 |
gamma-Hydroxybutyric acid binding sites: interaction with the GABA-benzodiazepine-picrotoxin receptor complex.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sodium Oxybate; Synaptic Membranes | 1992 |
Quantitative autoradiographic measurements of functional changes induced by generalized seizures in the developing rat brain: central adenosine and benzodiazepine receptors and local cerebral glucose utilization.
Topics: Age Factors; Animals; Autoradiography; Bicuculline; Blood Glucose; Brain; Brain Mapping; Epilepsy, Generalized; gamma-Aminobutyric Acid; Hippocampus; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Purinergic; Seizures; Status Epilepticus | 1992 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Synaptic Transmission | 1992 |
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
Topics: Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Globus Pallidus; Male; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Tiagabine | 1992 |
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
Topics: Animals; Anticonvulsants; Astrocytes; Behavior, Animal; Brain; Carbolines; Cells, Cultured; Convulsants; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Neurons; Nicotinic Acids; Nipecotic Acids; Oximes; Pentylenetetrazole; Rats; Seizures; Synaptosomes; Tiagabine | 1992 |
MK-801 prevents chemical kindling induced by pentylenetetrazol in rats.
Topics: Amino Acids; Animals; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures; Synaptic Transmission; Time Factors | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed | 1991 |
Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice.
Topics: Animals; Anticonvulsants; Catalepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Receptors, Dopamine; Receptors, GABA-A; Time Factors | 1991 |
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Topics: Amino Acids; Amino Acids, Neutral; Analgesics; Animals; Anticonvulsants; Body Temperature; Cannabidiol; Dronabinol; Electric Stimulation; Flurazepam; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Nipecotic Acids; Pentylenetetrazole; Seizures; Tiagabine | 1991 |
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Pentylenetetrazole; Probenecid; Rats; Rats, Inbred Strains; Serotonin; Valproic Acid | 1990 |
(4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Fatty Acids, Unsaturated; gamma-Aminobutyric Acid; Kinetics; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Vigabatrin | 1991 |
[Drug-induced seizures in taurine-deficient mice].
Topics: Amino Acids; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine; Taurine | 1991 |
Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect.
Topics: 4-Aminobutyrate Transaminase; Amine Oxidase (Copper-Containing); Amino Acids; Animals; Anticonvulsants; Brain Chemistry; Cell Membrane; Chlorides; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pentylenetetrazole; Putrescine; Rats; Rats, Inbred Strains; Seizures | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Tiagabine | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Aminobutyric Acid; Mesocricetus; Mutation; Pentylenetetrazole; Phenobarbital; Phenytoin; Synaptic Transmission; Valproic Acid | 1991 |
Synthesis and anticonvulsant activity of some benzopyranone imino derivatives of GABA and related compounds.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Chromans; gamma-Aminobutyric Acid; Imines; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Rats | 1991 |
Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Absence; Ethosuximide; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Succinimides; Thalamus | 1990 |
Characterization of GABAergic seizure regulation in the midline thalamus.
Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobutyric Acid; Pentobarbital; Pentylenetetrazole; Piperidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamic Nuclei | 1990 |
Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.
Topics: Animals; Anticonvulsants; Calcium Channels; Convulsants; Epilepsy, Absence; Ethosuximide; gamma-Aminobutyric Acid; Neurons; Pentylenetetrazole; Rats; Structure-Activity Relationship; Succinimides; Thalamus | 1990 |
Effects of the acute and chronic administration of chlordiazepoxide on the development of spontaneous motility in chick embryos.
Topics: Animals; Bicuculline; Chick Embryo; Chlordiazepoxide; gamma-Aminobutyric Acid; Movement; Pentylenetetrazole; Picrotoxin; Strychnine; Time Factors | 1989 |
Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Isoniazid; Isoxazoles; Male; Nervous System; Neuroglia; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1989 |
Are spontaneous activity and supraspinal control co-responsible for functional development of the generator of embryonic motility?
Topics: Animals; Central Nervous System; Chick Embryo; gamma-Aminobutyric Acid; Motor Activity; Motor Neurons; Pentylenetetrazole; Phenobarbital | 1989 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats.
Topics: Acetylcholinesterase; Animals; Brain; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Kindling, Neurologic; Kinetics; Male; Neuropeptide Y; Pentylenetetrazole; Rats; Rats, Inbred Strains; Somatostatin; Tissue Distribution | 1989 |
The effect of monoamine depletors on metrazol induced convulsions and brain gamma-aminobutyric acid (GABA) contents in rats.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1989 |
The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Pons; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Superior Colliculi | 1989 |
Injection of benzodiazepines but not GABA or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures.
Topics: Animals; Benzodiazepines; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra | 1989 |
Effects of muscimol, cetyl-GABA, pentetrazol and picrotoxin on timidity during intraspecies conflict in mice.
Topics: Aggression; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pentylenetetrazole; Picrotoxin; Species Specificity | 1989 |
Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors.
Topics: Animals; Anticonvulsants; Atropine; beta-Alanine; Bicuculline; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Indomethacin; Male; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stomach Ulcer; Taurine | 1988 |
Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex.
Topics: Animals; Carbolines; Chlordiazepoxide; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Male; Pentobarbital; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Interoceptive stimuli produced by an anxiogenic drug are mimicked by benzodiazepine antagonists in rats pretreated with isoniazid.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain Chemistry; Convulsants; Discrimination, Psychological; Flumazenil; gamma-Aminobutyric Acid; Humans; Isoniazid; Male; Pentobarbital; Pentylenetetrazole; Pyrazoles; Rats | 1985 |
Bidirectional modulation of GABA function by beta-carbolines.
Topics: Acoustic Stimulation; Anesthesia, General; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Barbiturates; Carbolines; Conflict, Psychological; Disease Models, Animal; gamma-Aminobutyric Acid; Memory; Mice; Mice, Inbred DBA; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Seizures | 1985 |
Consequences of chronic phenobarbital blockade of spontaneous motility in chick embryos for the development of central motor output activity.
Topics: Animals; Bicuculline; Central Nervous System; Chick Embryo; gamma-Aminobutyric Acid; Motor Activity; Oxazepam; Pentylenetetrazole; Phenobarbital; Strychnine | 1988 |
Dissociation of [35S]t-butylbicyclophosphorothionate binding differentiates convulsant and depressant drugs that modulate GABAergic transmission.
Topics: Animals; Barbiturates; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Central Nervous System Depressants; Cerebral Cortex; Convulsants; Etazolate; Etomidate; gamma-Aminobutyric Acid; Kinetics; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures.
Topics: 2-Aminoadipic Acid; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentylenetetrazole; Pipecolic Acids; Piperidines; Seizures; Synaptic Transmission | 1985 |
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Bicuculline; Body Temperature; Drug Interactions; Female; gamma-Aminobutyric Acid; Hypothermia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; Valproic Acid | 1985 |
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Receptors, GABA-A; Seizures | 1986 |
Cerebellar cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Bucladesine; Cerebellum; Diazepam; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Male; Nucleotides, Cyclic; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors | 1986 |
[Effects of GABA-ergic and glycinergic agents on pentamethylenetetrazole-induced convulsions in rats submitted to repeated injections of reserpine].
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Linoleic Acids; Male; Pentylenetetrazole; Psychotropic Drugs; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Reserpine; Seizures; Substantia Nigra | 1986 |
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide].
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Changes in GABA content of the brain and sensitivity to GABA-antagonists during and after repetitive treatment of rats with diphenilhydantoin.
Topics: Animals; Brain; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1988 |
Pentobarbital augments serotonin-mediated inhibition of cerebellar Purkinje cells.
Topics: Action Potentials; Animals; gamma-Aminobutyric Acid; Male; Neural Inhibition; Pentobarbital; Pentylenetetrazole; Picrotoxin; Purkinje Cells; Rats; Rats, Inbred Strains; Serotonin | 1988 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
Animal model for evaluating the convulsive liability of beta-lactam antibiotics.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Binding, Competitive; Cefazolin; Cilastatin; Cilastatin, Imipenem Drug Combination; Cyclopropanes; Disease Models, Animal; Drug Combinations; gamma-Aminobutyric Acid; Imipenem; Lactams; Male; Mice; Pentylenetetrazole; Seizures; Thienamycins | 1988 |
Possible involvement of the central GABAergic system in pentobarbital-stimulated gastric acid secretion in the perfused rat stomach preparation.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Male; Pentobarbital; Pentylenetetrazole; Perfusion; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Injections; Isoniazid; Mice; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Seizures; Vigabatrin | 1988 |
The role of enkephalins in the production of epileptogenic activity and autonomic dysfunction: origin of arrhythmia and sudden death in the epileptic patient?
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Death, Sudden; Enkephalins; Epilepsy; gamma-Aminobutyric Acid; Heart Rate; Humans; Models, Biological; Pentylenetetrazole | 1987 |
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Diazepam; Electroshock; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Male; Neural Inhibition; Pentobarbital; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1986 |
GABAergic drugs can enhance or attenuate chlordiazepoxide-induced sleep time in a heterogeneous strain of mice.
Topics: Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Chlordiazepoxide; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Picrotoxin; Sleep | 1986 |
Effect of valproate on brain GABA: comparison with various medium chain fatty acids.
Topics: Ammonia; Animals; Anticonvulsants; Brain Chemistry; Fatty Acids; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Valproic Acid | 1985 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Isoxazoles; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1985 |
Pentylenetetrazol-induced seizures produce an increased release of IR-Met-enkephalin from rat striatum in vitro.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Epilepsy; gamma-Aminobutyric Acid; In Vitro Techniques; Kindling, Neurologic; Male; Pentylenetetrazole; Potassium; Rats | 1985 |
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Haloperidol; Lithium; Male; Mice; Pentylenetetrazole; Picrotoxin | 1985 |
[Change in the activity of a cell-free protein-synthesizing system with different functional states of the central nervous system].
Topics: Anesthesia; Animals; Brain; Cell-Free System; Chlorpromazine; gamma-Aminobutyric Acid; Hexobarbital; In Vitro Techniques; Methionine; Microsomes; Nerve Tissue Proteins; Pentylenetetrazole; Rabbits; Seizures; Semicarbazides; Sulfur Radioisotopes; Thiopental | 1972 |
The influence of serotonin, GABA and DL-dopa on the circadian rhythm in the toxicity of picrotoxin, pentylenetetrazol and phenobarbital in mice.
Topics: Aminobutyrates; Animals; Circadian Rhythm; Dihydroxyphenylalanine; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Serotonin; Time Factors | 1974 |
Metabolism of glucose in cerebral cortex of rat in leptazol-induced convulsions and effect of gamma-aminobutyric acid on the same.
Topics: Aminobutyrates; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamine; In Vitro Techniques; Male; Pentylenetetrazole; Rats; Seizures | 1974 |
Modification of pyrazoloquinolinone affinity by GABA predicts efficacy at the benzodiazepine receptor.
Topics: Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Mice, Inbred Strains; Pentylenetetrazole; Pyrazoles; Radioligand Assay; Receptors, GABA-A; Seizures | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
Evidence that GABA mechanisms mediate the anxiolytic action of benzodiazepines: a study with valproic acid.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Discrimination Learning; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Valproic Acid | 1980 |
omega-Aminosulfonic acids as depressant or excitant compounds: their effect on the behavior and electroencephalogram of young chickens.
Topics: Alkanesulfonates; Alkanesulfonic Acids; Animals; Behavior, Animal; Central Nervous System Depressants; Central Nervous System Stimulants; Chickens; Electroencephalography; gamma-Aminobutyric Acid; Pentylenetetrazole; Picrotoxin; Structure-Activity Relationship; Strychnine; Taurine; Tubocurarine | 1983 |
Convulsant drugs: mechanisms of action.
Topics: Amino Acids; Barbiturates; Biological Transport, Active; Brain; Cholinesterase Inhibitors; Convulsants; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glycine; Humans; Neurons; Pentylenetetrazole; Substance P | 1980 |
Development of pentazol (metrazol) activation of spontaneous motility in chick embryos.
Topics: Animals; Central Nervous System; Chick Embryo; gamma-Aminobutyric Acid; Glycine; Motor Activity; Pentylenetetrazole | 1982 |
[Antiepileptic effects of complex therapy with vitamins and anticonvulsant preparations (experimental findings)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Therapy, Combination; gamma-Aminobutyric Acid; Mice; Niacinamide; Pantothenic Acid; Pentylenetetrazole; Phenobarbital; Pyridoxal Phosphate; Seizures; Vitamin E; Vitamins | 1982 |
Pharmacologic analysis of sodium valproate-induced suppression of secondary components of visual evoked potentials in albino rats.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Interactions; Evoked Potentials, Visual; Female; gamma-Aminobutyric Acid; Male; Naloxone; Pentylenetetrazole; Photic Stimulation; Picrotoxin; Rats; Synaptic Transmission; Time Factors; Valproic Acid | 1981 |
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
Enhanced binding of radioligands to receptors of gamma-aminobutyric acid and benzodiazepine by a new anticonvulsive agent, LY81067.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Triazines | 1983 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Valproic Acid | 1983 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Female; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Papio; Pentylenetetrazole; Photic Stimulation; Seizures; Strychnine; Valproic Acid | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Anticonvulsant activity of milacemide.
Topics: Acetamides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1983 |
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Myoclonus; Pentylenetetrazole; Picrotoxin; Quinolines; Rats; Rats, Inbred Strains; Seizures | 1984 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1982 |
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Body Temperature; Female; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Intraventricular; Isoxazoles; Male; Mice; Mice, Inbred DBA; Motor Activity; Nipecotic Acids; Pentylenetetrazole; Seizures | 1983 |
Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats.
Topics: Amygdala; Animals; Convulsants; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1982 |
Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability.
Topics: Animals; Dogs; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Seizures; Seizures, Febrile | 1982 |
Pentylenetetrazole induced changes in cerebellar energy metabolism.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Cerebellum; Energy Metabolism; gamma-Aminobutyric Acid; Glycogen; Muridae; Parietal Lobe; Pentylenetetrazole; Phosphocreatine; Purkinje Cells; Seizures | 1982 |
Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs.
Topics: Animals; Anticonvulsants; Electroshock; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole | 1982 |
Further evidence for a relationship between changes in GABA concentration in rat brain and enhanced monoamine-mediated behavioural responses following repeated electroconvulsive shock.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Quipazine; Rats; Rats, Inbred Strains | 1982 |
Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Seizures; Substantia Nigra | 1982 |
Baclofen as an anticonvulsant in experimental models of convulsions.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Seizures | 1981 |
On some relationships between GABA-ergic and 5-HT-ergic mechanisms in pentylenetetrazol convulsive-seizure reactions.
Topics: Animals; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Seizures; Serotonin | 1980 |
Carbohydrate metabolism in extraneural tissues in leptazol-induced convulsions & on gamma-aminobutyric acid pretreatment.
Topics: Animals; Carbohydrate Metabolism; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Seizures | 1981 |
[GABA-neurotransmitter and its relation with the convulsions: rate, synthesis, uptake and release at the synaptosomal level (author's transl)].
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Pentylenetetrazole; Rats; Synaptosomes | 1981 |
Relationship between drug-induced changes in seizure thresholds and the GABA content of brain and brain nerve endings.
Topics: Animals; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Nerve Endings; Pentylenetetrazole; Seizures; Synaptosomes | 1981 |
Cetyl GABA: effect on convulsant thresholds in mice and acute toxicity.
Topics: Animals; Brain Chemistry; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Seizures | 1980 |
Generalization and antagonism studies with convulsant, GABAergic and anticonvulsant drugs in rats trained to discriminate pentylenetetrazol from saline.
Topics: Animals; Anticonvulsants; Convulsants; Discrimination Learning; Drug Interactions; gamma-Aminobutyric Acid; Generalization, Psychological; Male; Pentylenetetrazole; Prejudice; Rats | 1980 |
Requirements for an ideal alcohol antagonist.
Topics: Alcoholic Intoxication; Animals; Caffeine; Cats; Dextroamphetamine; Disease Models, Animal; Dogs; Ethanol; gamma-Aminobutyric Acid; Humans; Maleates; Naloxone; Pentylenetetrazole; Rabbits; Strychnine | 1980 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Muscimol; Pentylenetetrazole; Pregnancy; Prenatal Exposure Delayed Effects; Radioisotopes; Seizures | 1995 |
The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Substantia Nigra; Valproic Acid; Vigabatrin | 1995 |
Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Phenylurea Compounds; Receptors, GABA; Seizures | 1995 |
Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cilastatin; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Imipenem; Injections, Intravenous; Male; Meropenem; Mice; Muscimol; Pentylenetetrazole; Rats; Receptors, GABA-A; Seizures; Thienamycins | 1995 |
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats.
Topics: Animals; Cerebral Cortex; Differential Threshold; Electroencephalography; Electronic Data Processing; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurons; Pentylenetetrazole; Picrotoxin; Pyridoxine; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Vitamin B 6 Deficiency | 1994 |
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms.
Topics: Alprazolam; Animals; Behavior, Animal; Desipramine; Disease Models, Animal; Dizocilpine Maleate; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Motivation; Motor Activity; Muscimol; N-Methylaspartate; Pentylenetetrazole; Psychotic Disorders; Rats; Rats, Wistar; Swimming | 1994 |
Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation.
Topics: Animals; Anticonvulsants; Cells, Cultured; Chloride Channels; Clonazepam; Desoxycorticosterone; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Neurons; Pentylenetetrazole; Progesterone; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chlorides; Endosulfan; Female; gamma-Aminobutyric Acid; Insecticides; Mice; Pentylenetetrazole; Picrotoxin; Pregnancy; Receptors, GABA-A; Sesterterpenes | 1994 |
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1994 |
gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Clonidine; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizures | 1994 |
Vigabatrin as an anticonvulsant against pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Seizures; Vigabatrin | 1993 |
Effect of pentylentetrazol (PTZ) kindling on GABAergic system: a histochemical study by staining for GABA-transaminase (GABA-T).
Topics: 4-Aminobutyrate Transaminase; Animals; Autoradiography; Brain; Cerebral Cortex; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Kindling, Neurologic; Male; Neurons; Pentylenetetrazole; Rats; Rats, Inbred Strains; Substantia Nigra | 1993 |
GABA-responses of CA3 neurones at epileptogenic threshold concentrations of convulsants.
Topics: Action Potentials; Animals; Bicarbonates; Bicuculline; Caffeine; Chlorides; Convulsants; Epilepsy; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Penicillins; Pentylenetetrazole; Synapses | 1993 |
Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Baclofen; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Organophosphorus Compounds; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA; Seizures | 1996 |
Inhibition of calcium spikes by gamma-amino-butyric acid in the neurons of Lymnaea stagnalis L.
Topics: Action Potentials; Animals; Baclofen; Calcium; GABA Agonists; gamma-Aminobutyric Acid; Ion Transport; Lymnaea; Muscimol; Neurons; Pentylenetetrazole; Pertussis Toxin; Receptors, GABA-B; Virulence Factors, Bordetella | 1995 |
Protracted treatment with diazepam reduces benzodiazepine1 receptor-mediated potentiation of gamma-aminobutyric acid-induced currents in dissociated rat hippocampal neurons.
Topics: Allosteric Regulation; Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 1996 |
In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis.
Topics: Allylglycine; Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Electroencephalography; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Tomography, Emission-Computed | 1997 |
Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Kindling, Neurologic; Male; Neural Inhibition; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Taurine | 1997 |
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold.
Topics: Animals; Anticonvulsants; Brain; Cells, Cultured; Chloride Channels; Convulsants; Drug Synergism; Fluorescent Dyes; Fructose; gamma-Aminobutyric Acid; Infusions, Intravenous; Mice; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Seizures; Topiramate | 1997 |
[Possible role of nitric oxide in pathogenesis of model seizure of the different etiology].
Topics: Animals; Brain; Convulsants; Electron Spin Resonance Spectroscopy; Electroshock; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; N-Methylaspartate; Nitric Oxide; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Semicarbazides | 1998 |
Anticonvulsant action of gabapentin during postnatal development in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Gabapentin; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 1997 |
Protective effect of clozapine against pentylenetetrazol convulsions and kindling.
Topics: Animals; Antipsychotic Agents; Clozapine; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Seizures | 1998 |
Anticonvulsant effect of progabide in rats during ontogenesis.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Convulsants; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 1997 |
Anticonvulsant effect of SL 75 102 in adult and immature rats.
Topics: Aging; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Pentylenetetrazole; Rats; Seizures | 1997 |
Ethopharmacological analysis of behaviour of rats using variations of the elevated plus-maze.
Topics: Animals; Anxiety; Behavior, Animal; Convulsants; Factor Analysis, Statistical; GABA Modulators; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Posture; Rats; Rats, Wistar; Synaptic Transmission | 1997 |
Pentylenetetrazol-induced kindling stimulates the polyamine interconversion pathway in rat brain.
Topics: Animals; Brain Chemistry; Brain Stem; Cerebral Cortex; Convulsants; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neurons; Oxidoreductases Acting on CH-NH Group Donors; Pentylenetetrazole; Polyamines; Putrescine; Rats; Rats, Wistar | 1999 |
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with No effect on benzodiazepine binding site density.
Topics: Animals; Autoradiography; Brain; Down-Regulation; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1999 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamates; Humans; Kynurenic Acid; Lidocaine; Limbic System; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Solitary Nucleus; Synaptic Transmission; Vagus Nerve | 1999 |
Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy.
Topics: Animals; Convulsants; Electroencephalography; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Generalized; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Male; Pentylenetetrazole; Rats; Rats, Mutant Strains; Rats, Wistar | 1999 |
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Mice; Mollusk Venoms; Oocytes; Pentylenetetrazole; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Sound; Xenopus | 2000 |
Long-lasting effects of GABA infusion into the cerebral cortex of the rat.
Topics: Animals; Anisomycin; Cerebral Cortex; Convulsants; Electric Stimulation; Epilepsy; gamma-Aminobutyric Acid; In Vitro Techniques; Injections; Long-Term Potentiation; Male; Pentylenetetrazole; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Time Factors | 2000 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electroshock; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Magnesium Deficiency; Mice; N-Methylaspartate; Patch-Clamp Techniques; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Seizures; Sodium Channel Blockers; Structure-Activity Relationship; Synaptosomes; Tumor Cells, Cultured | 2000 |
Central action of some cytostatics--methotrexate (MTX) and doxorubicin (DXR). II. The influence on the seizure activity and the learning and memory processes in mice.
Topics: Animals; Brain; Doxorubicin; Drug Interactions; Female; gamma-Aminobutyric Acid; Hexobarbital; Learning; Male; Memory; Methotrexate; Mice; Pentylenetetrazole; Seizures; Sleep | 1998 |
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Clonazepam; Evoked Potentials; Flumazenil; Fructose; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Receptors, GABA; Seizures; Topiramate | 2000 |
The central nervous system convulsant pentylenetetrazole stimulates gamma-aminobutyric acid (GABA)-activated current in picrotoxin-resistant GABA(A) receptors in HEK293 cells.
Topics: Animals; Cells, Cultured; Convulsants; gamma-Aminobutyric Acid; Ion Channel Gating; Pentylenetetrazole; Receptors, GABA-A; Transfection | 2000 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Hepatic Encephalopathy; Linear Models; Male; Neurons; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 1999 |
GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Cerebral Ventricles; Cocaine; Convulsants; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Injections; Male; Mice; Mice, Inbred BALB C; Neurons; Oligodeoxyribonucleotides, Antisense; Pentylenetetrazole; Seizures; Time Factors | 1999 |
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Convulsants; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Lithium; Male; Mice; Muscarinic Agonists; Pentobarbital; Pentylenetetrazole; Pilocarpine; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Serotonin; Sleep | 2000 |
Modification of behavioral effects of drugs in mice by neuroactive steroids.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Convulsants; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Pregnenolone; Psychotropic Drugs; Steroids; Synaptic Transmission | 2000 |
GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
Topics: Acoustic Stimulation; Anesthesia; Animals; Anisoles; Anticonvulsants; Carbazoles; Chromatography, High Pressure Liquid; Convulsants; Electroshock; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Mice; Mice, Inbred DBA; Microdialysis; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Pentylenetetrazole; Piperidines; Seizures; Substantia Nigra; Thalamus; Tiagabine | 2000 |
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzaldehydes; Brain; Convulsants; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; Neurotransmitter Agents; Pentylenetetrazole; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid | 2000 |
Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system.
Topics: Amygdala; Animals; Dentate Gyrus; Electric Stimulation; Electrodes, Implanted; Epilepsy; Evoked Potentials; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Kindling, Neurologic; Neural Inhibition; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Wistar; Reaction Time; Seizures; Synapses; Synaptic Transmission | 2000 |
Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Brain; Convulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Hypogonadism; Male; Mice; Mice, Knockout; Pentylenetetrazole; Reaction Time; Receptors, Androgen; Seizures; Testosterone | 2001 |
Effects of antisense glutamic acid decarboxylase oligodeoxynucleotide on epileptic rats induced by pentylenetetrazol.
Topics: Animals; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Isoenzymes; Kindling, Neurologic; Male; Oligonucleotides, Antisense; Pentylenetetrazole; Rats | 2002 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flurazepam; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mesocricetus; Microinjections; Muscimol; Pentylenetetrazole; Phenobarbital | 2002 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Chronic Disease; Convulsants; Cyclohexanecarboxylic Acids; Drug Stability; Gabapentin; gamma-Aminobutyric Acid; Hypothermia; Imipramine; Infusion Pumps, Implantable; Ketamine; Male; Morphine; Pain; Pain Measurement; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Solubility; Tetrabenazine | 2002 |
Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Brain Chemistry; Electroshock; Fabaceae; gamma-Aminobutyric Acid; India; Locomotion; Male; Medicine, Ayurvedic; Mice; Pentobarbital; Pentylenetetrazole; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Seizures; Serotonin; Sleep | 2002 |
Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cell Line; Chloride Channels; Convulsants; Electrophysiology; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Point Mutation; Rats; Transfection | 2002 |
N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities.
Topics: Animals; Anticonvulsants; Binding Sites; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Models, Molecular; Pentylenetetrazole; Pilocarpine; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Toxicity Tests | 2003 |
Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Synergism; Felbamate; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Lamotrigine; Mice; Pentylenetetrazole; Phenylcarbamates; Potassium Channel Blockers; Propylene Glycols; Rats; Seizures; Triazines | 2003 |
Pentylenetetrazol-induced seizures in immature rats provoke long-term changes in adult hippocampal cholinergic excitability.
Topics: Acetylcholine; Age Factors; Animals; Animals, Newborn; Cholinergic Fibers; Cholinesterase Inhibitors; Convulsants; Cortical Synchronization; Culture Techniques; Epilepsy, Generalized; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Long-Term Potentiation; Membrane Potentials; Pentylenetetrazole; Physostigmine; Rats; Rats, Sprague-Dawley | 2003 |
Pentylenetetrazole decreases metabolic glutamate turnover in rat brain.
Topics: Animals; Brain; Brain Chemistry; Carbon Isotopes; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Apomorphine; Avoidance Learning; Biguanides; Brain Chemistry; Chlordiazepoxide; Clonidine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; GABA Agents; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Male; Memantine; Mephenytoin; Microinjections; Pentylenetetrazole; Phentolamine; Picrotoxin; Piperazines; Propranolol; Pyrimidines; Rats; Serotonin; Sulpiride; Ventromedial Hypothalamic Nucleus; Yohimbine | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid | 2003 |
STUDIES ON SOME ANALOGUES OF GAMMA-AMINOBUTYRIC ACID.
Topics: Aminobutyrates; Bemegride; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Pharmacology; Research; Strychnine; Toxicology | 1963 |
ANTICONVULSIVE ACTION OF SUBSTANCES DESIGNED AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID-ALPHA-KETOGLUTARIC ACID TRANSAMINASE.
Topics: Aminobutyrates; Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Electricity; Electroshock; Enzyme Inhibitors; gamma-Aminobutyric Acid; Ketoglutaric Acids; Mice; Pentylenetetrazole; Pharmacology; Rats; Research; Seizures; Thiosemicarbazones; Transaminases | 1964 |
A NEUROPHARMACOLOGICAL STUDY OF GAMMA-AMINOBUTYRIC ACID (GABA).
Topics: Aminobutyrates; Anesthesia; Anesthesia, Intravenous; Behavior, Animal; Brain Chemistry; Cats; Chlorpromazine; Electroencephalography; Electroshock; gamma-Aminobutyric Acid; Hydroxylamines; Metabolism; Neuropharmacology; Pentobarbital; Pentylenetetrazole; Pharmacology; Phenytoin; Research; Reserpine; Seizures; Strychnine; Toxicology | 1964 |
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Brain; Cell Count; Crosses, Genetic; Dose-Response Relationship, Drug; Drug Resistance; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Transgenic; Neurons; Pentylenetetrazole; Piperidines; Putrescine; Seizures | 2003 |
Differential sensitivity of genetically Fast vs. Slow kindling rats strains to GABAergic convulsive agents.
Topics: Animals; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine Agents; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Long-Evans; Rats, Wistar; Species Specificity; Strychnine | 2003 |
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain.
Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid | 2003 |
Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study.
Topics: Amines; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Seizures; Tiagabine | 2004 |
Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures.
Topics: Action Potentials; Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Hippocampus; Interneurons; Mice; Mice, Knockout; Nerve Net; Neural Inhibition; Parvalbumins; Pentylenetetrazole; Pyramidal Cells; Receptors, GABA-A; Synaptic Transmission | 2004 |
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Topics: Alleles; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Codon, Nonsense; Cytoskeleton; Disease Models, Animal; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Microtubule-Associated Proteins; Molecular Sequence Data; Neurons; Pentylenetetrazole; RNA, Small Interfering; Seizures; Sequence Alignment; Synaptic Vesicles | 2004 |
Posttraining administration of pentylenetetrazol dissociates gabapentin effects on memory consolidation from that on memory retrieval process in mice.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Convulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Gabapentin; gamma-Aminobutyric Acid; Male; Memory; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Reaction Time; Retention, Psychology; Time Factors | 2004 |
Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Pregnanolone; Seizures | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Cloning, Molecular; Convulsants; Drug Synergism; Epilepsy; Epilepsy, Reflex; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; N-Acetylglucosaminyltransferases; Neurons; Nipecotic Acids; Pentylenetetrazole; Pilocarpine; Psychomotor Disorders; Recombinant Proteins; Seizures; Tiagabine | 2005 |
Blockade of the membranal GABA transporter potentiates GABAergic responses evoked in pyramidal cells by mossy fiber activation after seizures.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Transport Modulators; Membrane Transport Proteins; Mossy Fibers, Hippocampal; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Synaptic Membranes; Synaptic Transmission | 2005 |
Beneficial interaction between vigabatrin and valproate against seizures induced by pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Drug Synergism; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Pentylenetetrazole; Valproic Acid; Vigabatrin | 2005 |
The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin.
Topics: Acetates; Adamantane; Amines; Analgesics; Animals; Anticonvulsants; Calcium Channels; Cell Line; Cell Membrane; Cyclohexanecarboxylic Acids; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Mice; Models, Animal; Molecular Structure; Pentylenetetrazole; Rats; Semicarbazides; Structure-Activity Relationship | 2005 |
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebellum; Electric Stimulation; Electroencephalography; Exploratory Behavior; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gait Disorders, Neurologic; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; In Vitro Techniques; Inhibition, Psychological; Isoenzymes; Maze Learning; Membrane Potentials; Mice; Mice, Knockout; Motor Activity; Neurons; Pentylenetetrazole; Psychomotor Performance; Pyridazines; Receptors, GABA-A; Reflex, Acoustic; Rotarod Performance Test; Seizures; Synaptosomes; Tremor; Vesicular Inhibitory Amino Acid Transport Proteins | 2005 |
CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats.
Topics: Analysis of Variance; Animals; Blotting, Western; Choline O-Acetyltransferase; Drug Interactions; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Kindling, Neurologic; Male; Models, Animal; Neuropeptide Y; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sincalide | 2005 |
Study of antiepileptic effect of extracts from Acorus tatarinowii Schott.
Topics: Acorus; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Hot Temperature; Immunohistochemistry; Kindling, Neurologic; Male; Mice; Neurons; Oils, Volatile; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rhizome; Seizures | 2005 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; gamma-Aminobutyric Acid; Hippocampus; Isotopes; Ovariectomy; Pentylenetetrazole; Progestins; Rats; Rats, Long-Evans; Reaction Time; Receptors, GABA-A; Seizures; Tissue Distribution | 2005 |
Target-specific catecholamine elevation induced by anticonvulsant thalamic deep brain stimulation.
Topics: Animals; Brain; Catecholamines; Chromatography, High Pressure Liquid; Deep Brain Stimulation; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Pentylenetetrazole; Random Allocation; Rats; Seizures; Stereotaxic Techniques; Thalamus; Tissue Distribution | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Nipecotic Acids; Oxcarbazepine; Pentylenetetrazole; Seizures; Tiagabine | 2005 |
Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.
Topics: Animals; Benzene Derivatives; Brain; Chelating Agents; Convulsants; Dimercaprol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Neural Inhibition; Organoselenium Compounds; Pentylenetetrazole; Reaction Time; Receptors, GABA; Seizures; Survival Rate; Time Factors | 2006 |
Neuropharmacological effects of deltamethrin in rats.
Topics: Animals; Ataxia; Brain; Female; gamma-Aminobutyric Acid; Insecticides; Male; Molecular Structure; Nitriles; Pentylenetetrazole; Phenobarbital; Pyrethrins; Rats; Rats, Wistar; Seizures; Sleep | 2006 |
[Saikosaponins inhibit increased glutamate and GABA expressions in the hippocampus of pentetrazole-induced slow kindling rats].
Topics: Animals; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Immunohistochemistry; Kindling, Neurologic; Male; Oleanolic Acid; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Movement; Computational Biology; Disease Susceptibility; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Green Fluorescent Proteins; Microinjections; Microtubule-Associated Proteins; Models, Biological; Molecular Sequence Data; Pentylenetetrazole; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Seizures; Synaptic Transmission; Synaptic Vesicles | 2006 |
Autocorrelogram sorting: a novel method for evaluating negative-feedback regulation of spike firing.
Topics: Acetylcholine; Action Potentials; Animals; Cholinergic Fibers; Convulsants; Electrophysiology; Feedback; gamma-Aminobutyric Acid; Hippocampus; Male; Neural Inhibition; Neurons; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Signal Processing, Computer-Assisted; Synaptic Transmission | 2007 |
Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling.
Topics: Amino Acids; Animals; Brain; Convulsants; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Kindling, Neurologic; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Pentylenetetrazole; Seizures; Taurine | 2006 |
Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots.
Topics: Acetates; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Central Nervous System Depressants; Cerebral Cortex; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Ipomoea; Male; Mice; Mice, Inbred ICR; Motor Activity; Neurotransmitter Agents; Pentobarbital; Pentylenetetrazole; Plant Extracts; Plant Roots; Seizures; Solvents; Swimming | 2007 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred CBA; Motor Activity; Pentylenetetrazole; Picrotoxin; Pyridines; Zolpidem | 2008 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Models, Animal; Donepezil; Down Syndrome; Drug Administration Schedule; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Indans; Male; Maze Learning; Memory Disorders; Mice; Mice, Neurologic Mutants; Neural Inhibition; Pentylenetetrazole; Piperidines; Receptors, GABA-A; Treatment Outcome; Trisomy | 2008 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Pentylenetetrazole; Rats; Rats, Wistar; Rutin; Seizures | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 2008 |
Neuropharmacological studies on Wedelia calendulacea Less stem extract.
Topics: Analgesics; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Drug Evaluation, Preclinical; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Locomotion; Male; Mass Spectrometry; Mice; Motor Activity; Neuropharmacology; Pentobarbital; Pentylenetetrazole; Plant Extracts; Plant Stems; Plants, Medicinal; Rats; Sleep; Strychnine; Wedelia | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Crystallography, X-Ray; gamma-Aminobutyric Acid; Humans; Hydrogen Bonding; Imidazoles; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 2008 |
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.
Topics: Analysis of Variance; Animals; Biophysics; Cell Count; Electric Stimulation; gamma-Aminobutyric Acid; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neural Pathways; Neuronal Plasticity; Neuropilin-2; Patch-Clamp Techniques; Pentylenetetrazole; Receptors, GABA; Seizures; Silver Staining; Synapses | 2009 |
Tramadol-induced seizurogenic effect: a possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway.
Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; GABA Agents; Gabapentin; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Pentylenetetrazole; Receptors, GABA; Receptors, Opioid; Seizures; Tramadol | 2008 |
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Muscle Strength; Pentylenetetrazole; Psychomotor Performance; Seizures; Vigabatrin | 2008 |
Developmental impact of a familial GABAA receptor epilepsy mutation.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Net; Neural Inhibition; Pentylenetetrazole; Receptors, GABA-A; Tetracycline | 2008 |
Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antitubercular Agents; Central Nervous System; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ipomoea; KB Cells; Mexico; Mice; Models, Animal; Oligosaccharides; Pentobarbital; Pentylenetetrazole; Plant Roots; Plants, Medicinal; Tuberculosis | 2008 |
Hippocampal-dependent learning requires a functional circadian system.
Topics: Animals; Circadian Rhythm; Cricetinae; Female; gamma-Aminobutyric Acid; Hippocampus; Learning; Male; Pentylenetetrazole; Phodopus; Sleep | 2008 |
Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype.
Topics: Age Factors; Analysis of Variance; Animals; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Frontal Lobe; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; In Vitro Techniques; Leucine; Microscopy, Immunoelectron; Motor Activity; Motor Skills; Mutation; Neurotransmitter Agents; Nicotine; Pain Measurement; Pentylenetetrazole; Phenotype; Rats; Rats, Transgenic; Receptors, Nicotinic; Serine; Synaptic Transmission | 2008 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Interactions; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Levetiracetam; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Piracetam; Seizures; Tiagabine; Tissue Distribution; Vigabatrin | 2009 |
Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats.
Topics: Acoustic Stimulation; Action Potentials; Animals; Animals, Newborn; Apomorphine; Calbindin 2; Calbindins; Dopamine Agonists; Electroencephalography; Female; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Hippocampus; Ibotenic Acid; Locomotion; Male; Neural Inhibition; Parvalbumins; Pentylenetetrazole; Rats; Reflex, Startle; S100 Calcium Binding Protein G; Seizures; Synaptic Transmission | 2009 |
The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Receptors, Metabotropic Glutamate; Taurine | 2009 |
Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Cyclohexane Monoterpenes; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; gamma-Aminobutyric Acid; Glutathione; Hippocampus; Lipid Peroxidation; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Receptors, GABA-A; Seizures; Terpenes | 2009 |
The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) N.E. Brown chemotypes.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flavonoids; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Lippia; Male; Mice; Motor Skills; Oils, Volatile; Pentylenetetrazole; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Rotarod Performance Test; Seizures; Terpenes | 2009 |
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Brain Mapping; Caspase 3; Cell Death; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Acid; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glutamate Decarboxylase; Green Fluorescent Proteins; Homeodomain Proteins; Intermediate Filament Proteins; Interneurons; LIM-Homeodomain Proteins; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nestin; Neural Inhibition; Parvalbumins; Pentylenetetrazole; Seizures; Signal Transduction; Social Behavior; Transcription Factors | 2009 |
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.
Topics: Aldicarb; Animals; Biological Transport; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Membrane; Dyneins; gamma-Aminobutyric Acid; Integrins; Larva; Male; Microtubule-Associated Proteins; Motor Neurons; Mutation; Pentylenetetrazole; Pharmacogenetics; rac GTP-Binding Proteins; RNA Interference; Seizures; Synaptic Transmission; Synaptic Vesicles | 2009 |
Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Avoidance Learning; Brain; Disease Susceptibility; Electroencephalography; Enzyme-Linked Immunosorbent Assay; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Hepatocyte Growth Factor; Humans; Interneurons; Mice; Neural Inhibition; Parvalbumins; Pentylenetetrazole; Reaction Time; Receptors, Urokinase Plasminogen Activator; Seizures | 2010 |
Age- and dose-specific anticonvulsant action of bumetanide in immature rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2 | 2009 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Glutathione; Lipid Peroxidation; Magnesium; Male; Nitric Oxide; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Seizures; Statistics, Nonparametric; Valproic Acid | 2010 |
Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method.
Topics: Animals; Anticonvulsants; Anxiety; Dose-Response Relationship, Drug; Flavonoids; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred Strains; Passiflora; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures; Temperature | 2010 |
Targeting γ-aminobutyric acid (GABA) carriers to the brain: potential relevance as antiepileptic pro-drugs.
Topics: Animals; Blood-Brain Barrier; Epilepsy; Female; GABA Agonists; gamma-Aminobutyric Acid; Male; Mice; Models, Animal; Pentylenetetrazole; Prodrugs; Thiazines; Thiones | 2010 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Convulsants; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; gamma-Aminobutyric Acid; Glutamates; Glutamine; Male; Pentylenetetrazole; Progesterone; Rats; Rats, Sprague-Dawley; Seizures; Vitamins | 2010 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Glutamic Acid; Neurons; Pentylenetetrazole; Valproic Acid | 2011 |
Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans.
Topics: Animals; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Proteins; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Phosphoric Monoester Hydrolases; R-SNARE Proteins; Synapses; Synaptic Transmission; Synaptic Vesicles; Synaptogyrins; Synaptotagmins | 2011 |
An in vitro model for testing drugs to treat tinnitus.
Topics: Amines; Animals; Antioxidants; Calcium Channel Blockers; Carnitine; Convulsants; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Gabapentin; gamma-Aminobutyric Acid; Indoles; Mice; Neurons; Pentylenetetrazole; Potassium Channel Blockers; Pregabalin; Pyridines; Tinnitus | 2011 |
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Fatty Acids, Volatile; Flavones; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Motor Activity; Oocytes; Pentylenetetrazole; Receptors, GABA-A; Recombinant Proteins; Thiopental; Xenopus | 2011 |
GABAergic synaptic plasticity during a developmentally regulated sleep-like state in C. elegans.
Topics: Adjuvants, Anesthesia; Aldicarb; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cholinesterase Inhibitors; Epidermal Growth Factor; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Larva; Muscimol; Muscle Contraction; Mutation; Neuromuscular Junction; Pentylenetetrazole; RNA Interference; Sleep; Sodium Oxybate; Time Factors; Transcription Factors; Tretinoin | 2011 |
Influence of carvedilol on anticonvulsant effect of gabapentin.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Brain; Carbazoles; Carvedilol; Convulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Electroshock; Exploratory Behavior; Gabapentin; gamma-Aminobutyric Acid; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Memory; Mice; Motor Activity; Pentylenetetrazole; Propanolamines; Rotarod Performance Test; Seizures; Vasodilator Agents | 2011 |
Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Apigenin; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Neuroprotective Agents; Pennisetum; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2012 |
Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Hand Strength; Male; Mice; Motor Skills; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Seizures; Sildenafil Citrate; Sulfones; Vigabatrin | 2012 |
Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbon; Folic Acid; gamma-Aminobutyric Acid; Larva; Models, Neurological; Neurons; Neurotoxins; Pentylenetetrazole; Primidone; Pyridoxal Phosphate; Pyridoxine; Seizures; Swimming; Zebrafish | 2012 |
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase.
Topics: Animals; Astrocytes; Blotting, Western; Chromatography, High Pressure Liquid; Convulsants; Electroshock; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Histamine H1 Antagonists; Histidine Decarboxylase; Immunohistochemistry; Kindling, Neurologic; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 2012 |
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pentylenetetrazole; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serine; Synaptic Transmission | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Gene Expression; Male; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid; Zebrafish | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred Strains; Microdialysis; Pentylenetetrazole; Pilocarpine; Seizures; Tea | 2013 |
Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish.
Topics: Action Potentials; Administration, Oral; Amines; Analysis of Variance; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Locomotion; Male; Pentylenetetrazole; Seizures; Time Factors; Zebrafish | 2013 |
Anticonvulsant activity of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose isolated from leaves of Mangifera indica.
Topics: Animals; Anticonvulsants; Brain; Electroshock; gamma-Aminobutyric Acid; Hydrolyzable Tannins; Male; Mangifera; Mice; Motor Activity; Pentylenetetrazole; Phytotherapy; Plant Leaves; Seizures | 2013 |
Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Lobelia; Lobeline; Male; Mice; Pentylenetetrazole; Plant Extracts; Seizures | 2012 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; gamma-Aminobutyric Acid; Heterocyclic Compounds, 3-Ring; Hypnotics and Sedatives; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Psychomotor Performance; Seizures; Sleep | 2013 |
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; gamma-Aminobutyric Acid; Hypericum; Male; Medicine, Traditional; Mice; Nitric Oxide; Pentylenetetrazole; Picrotoxin; Plant Extracts; Seizures; Time Factors | 2013 |
Design of benzothiazole-1,3,4-thiadiazole conjugates: synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Benzothiazoles; Brain; Disease Models, Animal; Drug Design; Electroshock; gamma-Aminobutyric Acid; Liver; Male; Mice; Molecular Structure; Pentylenetetrazole; Rats, Wistar; Seizures; Structure-Activity Relationship; Thiadiazoles | 2013 |
Antiepileptic potential of matrine via regulation the levels of gamma-aminobutyric acid and glutamic acid in the brain.
Topics: Alkaloids; Animals; Anticonvulsants; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Glycine; Male; Matrines; Mice; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Seizures; Up-Regulation | 2013 |
The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Hippocampus; Male; Mice, Inbred ICR; Ondansetron; Pentylenetetrazole; Piperidines; Proto-Oncogene Proteins c-fos; Seizures; Survival Analysis | 2014 |
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.
Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Chemistry Techniques, Synthetic; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Male; Mice; Motor Activity; Pentylenetetrazole; Pilocarpine; Rotarod Performance Test; Seizures; Structure-Activity Relationship | 2014 |
Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Carriers; Drug Compounding; Electroshock; Gabapentin; gamma-Aminobutyric Acid; Male; Nanoparticles; Pentylenetetrazole; Polysorbates; Rats, Wistar; Seizures; Serum Albumin, Bovine | 2014 |
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mesenchymal Stem Cell Transplantation; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Umbilical Cord | 2014 |
Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats.
Topics: Animals; Benzoxazoles; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Isoquinolines; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pentylenetetrazole; Pyridines; Rats; Seizures; Urea | 2015 |
Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery.
Topics: Aluminum Silicates; Animals; Brain; Cell Survival; Clay; Drug Carriers; Drug Liberation; Drug Stability; gamma-Aminobutyric Acid; Male; Nanotubes; Particle Size; Pentylenetetrazole; Rats; Seizures; Sterilization | 2015 |
Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice.
Topics: Animals; Comorbidity; Epilepsy; gamma-Aminobutyric Acid; Glucagon-Like Peptide 1; Glutamic Acid; Glutathione; Kindling, Neurologic; Liraglutide; Male; Mice; Nitrites; Pentylenetetrazole | 2016 |
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models.
Topics: Animals; Basal Ganglia; Disease Models, Animal; Electric Stimulation; Female; gamma-Aminobutyric Acid; Microinjections; Pentylenetetrazole; Rats, Wistar; Seizures; Substantia Nigra; Subthalamic Nucleus; Vigabatrin | 2016 |
Design, Synthesis, and Biological Evaluation of 6-(2-Amino-substituted phenyl)-4-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Electroshock; gamma-Aminobutyric Acid; Mice; Molecular Docking Simulation; Neuroprotective Agents; Pentylenetetrazole; Receptors, GABA-A; Seizures; Sodium Channels; Structure-Activity Relationship; Triazines | 2016 |
Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Animals; Blood Glucose; Body Weight; Convulsants; Diet, Ketogenic; Electroencephalography; gamma-Aminobutyric Acid; Male; Neurons; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Substantia Nigra | 2016 |
Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Cromakalim; Dose-Response Relationship, Drug; Drug Therapy, Combination; gamma-Aminobutyric Acid; KATP Channels; Male; Mice; Morphine; Pentylenetetrazole; Pyridines; Seizures; Zolpidem | 2016 |
6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain.
Topics: Amines; Animals; Computer Simulation; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Female; Flavanones; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Models, Molecular; Naloxone; Neuralgia; Nociception; Pentylenetetrazole; Rats, Sprague-Dawley; Receptors, GABA; Streptozocin; Toxicity Tests, Acute; Vulvodynia | 2016 |
Protective effect of spermine against pentylenetetrazole kindling epilepsy induced comorbidities in mice.
Topics: Animals; Arginine; Avoidance Learning; Brain; Catecholamines; Comorbidity; Depression; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Kindling, Neurologic; Male; Mice; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Pentylenetetrazole; Spermine | 2017 |
Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism.
Topics: Animals; Anticonvulsants; Brain; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Lamiaceae; Medicine, Traditional; Methanol; Mice; Models, Theoretical; Pentylenetetrazole; Phytotherapy; Plant Extracts; Plant Roots; Seizures; Solvents | 2017 |
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Fragile X Mental Retardation Protein; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Piperidines; Potassium Channel Blockers; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures | 2017 |
Neuropharmacological and neuroprotective activities of some metabolites produced by cell suspension culture of Waltheria americana Linn.
Topics: Animals; Anticonvulsants; Biomass; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Malvaceae; Metabolome; Mice; Neurons; Neuroprotective Agents; Pentylenetetrazole; Plant Extracts; Seizures; Solubility; Suspensions | 2017 |
Impairment of GABAergic system contributes to epileptogenesis in glutaric acidemia type I.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Blotting, Western; Brain; Brain Diseases, Metabolic; Chromatography, High Pressure Liquid; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Glutaryl-CoA Dehydrogenase; Mice; Mice, Knockout; Pentylenetetrazole; Synaptosomes | 2017 |
Evidence for the involvement of the GABA-ergic pathway in the anticonvulsant activity of the roots bark aqueous extract of Anthocleista djalonensis A. Chev. (Loganiaceae).
Topics: Animals; Anticonvulsants; Benzodiazepines; gamma-Aminobutyric Acid; Loganiaceae; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Phytotherapy; Plant Bark; Plant Extracts; Plant Roots; Seizures | 2017 |
A species dependent response to the pro-epileptic drug pentylentetrazole in birds.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Myoclonus; Neurons; Parrots; Pentylenetetrazole; Phenotype; Seizures; Sparrows; Species Specificity; Telencephalon | 2017 |
SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 1; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; MicroRNAs; Oleanolic Acid; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats, Wistar; Saponins; Transcription Factor AP-1 | 2017 |
Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Calcitonin; Drug Synergism; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Pregabalin; Seizures; Valproic Acid | 2018 |
Anticonvulsant effects after grafting of rat, porcine, and human mesencephalic neural progenitor cells into the rat subthalamic nucleus.
Topics: Animals; Convulsants; Disease Models, Animal; Embryo, Mammalian; Epilepsy; Fetus; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Median Eminence; Mesencephalon; Nestin; Neural Stem Cells; Pentylenetetrazole; Rats; Somatostatin; Species Specificity; Subthalamic Nucleus; Swine; Tubulin | 2018 |
Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Drug Interactions; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Locomotion; Maze Learning; Neuropeptide Y; Pentylenetetrazole; Seizures; Zebrafish | 2019 |
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Pentylenetetrazole; Seizures | 2018 |
The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression; Glutamate Decarboxylase; Hippocampus; Male; Pentylenetetrazole; Physical Conditioning, Animal; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Signal Transduction | 2019 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Male; Mice; Nitric Oxide; Oils, Volatile; Pentylenetetrazole; Plant Leaves; Plant Oils; Salvia; Seizures; Synaptic Transmission | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethosuximide; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizures; Time Factors; Valproic Acid; Vigabatrin | 2020 |
NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Humans; Locomotion; Morpholinos; Mutagenesis; NAV1.1 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pentylenetetrazole; Phenotype; RNA, Guide, Kinetoplastida; RNA, Messenger; Voltage-Gated Sodium Channel Agonists; Voltage-Gated Sodium Channel Blockers; Zebrafish; Zebrafish Proteins | 2020 |
Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Glucosides; Lamiaceae; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phenols; Plant Extracts; Plant Roots; Signal Transduction | 2020 |
Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures.
Topics: Animals; Animals, Newborn; Body Temperature; Cells, Cultured; Extracellular Fluid; gamma-Aminobutyric Acid; Hippocampus; Hyperthermia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pentylenetetrazole; Seizures; Synapses; Syntaxin 1 | 2021 |
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, Animal; Estradiol; gamma-Aminobutyric Acid; Hydrocortisone; Male; Neuroprotective Agents; Normetanephrine; Oxadiazoles; Oxidative Stress; Pentylenetetrazole; Pregnanolone; Progesterone; Reactive Oxygen Species; Seizures; Serotonin; Zebrafish | 2021 |
Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Juglans; Mice; Nitric Oxide; Pentylenetetrazole; Peptides; Seizures | 2021 |
OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Kindling, Neurologic; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Transaminases; Vigabatrin | 2021 |
The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats.
Topics: Animals; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Phenols; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Serotonin; Seizures; Sulfonamides | 2022 |
Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis.
Topics: Animals; Anthozoa; Anticonvulsants; gamma-Aminobutyric Acid; Glutamates; Humans; Molecular Docking Simulation; Pentylenetetrazole; Peptides; Phylogeny; Receptors, GABA-A; Transcriptome; Zebrafish | 2022 |
HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA
Topics: 14-3-3 Proteins; Animals; Epilepsy; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Pentylenetetrazole; Rats; Receptors, GABA-A; Seizures; Synaptic Transmission | 2022 |
Stem bark chloroform extract of Bombax costatum Pellegr. & Vuillet exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Bombax; Chloroform; gamma-Aminobutyric Acid; Neuroprotective Agents; Pentylenetetrazole; Plant Bark; Rats; Seizures | 2023 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Molecular Docking Simulation; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 2022 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetetrazole; Rats; Receptors, GABA-A; Seizures; Synaptic Transmission | 2023 |
Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Topics: Albizzia; Amnesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Epilepsy; gamma-Aminobutyric Acid; Kindling, Neurologic; Memory Disorders; Mice; Neuroinflammatory Diseases; Oxidative Stress; Pentylenetetrazole; Plant Extracts; Seizures; Water | 2023 |
Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies.
Topics: Animals; Anticonvulsants; Antioxidants; Chloroform; Epilepsy; Gallic Acid; gamma-Aminobutyric Acid; Grewia; Hexanes; Kaempferols; Methanol; Mice; Pentylenetetrazole; Plant Extracts; Receptors, AMPA; Seizures | 2023 |
The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties.
Topics: Alchemilla; Animals; Anticonvulsants; Antioxidants; Catalase; Epilepsy; Female; gamma-Aminobutyric Acid; Glutathione; Kindling, Neurologic; Male; Malondialdehyde; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Rosaceae; Seizures; Transaminases | 2023 |
Effects of probiotics on GABA/glutamate and oxidative stress in PTZ- induced acute seizure model in rats.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Male; Oxidative Stress; Pentylenetetrazole; Probiotics; Rats; Rats, Wistar; Seizures | 2023 |
Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.
Topics: Acorus; Animals; Anticonvulsants; Anxiety; Epilepsy; gamma-Aminobutyric Acid; Inflammation; Mice; Oxidative Stress; Pentylenetetrazole; Polygala; Seizures | 2023 |