pentylenetetrazole has been researched along with flunitrazepam in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (48.78) | 18.7374 |
| 1990's | 16 (39.02) | 18.2507 |
| 2000's | 2 (4.88) | 29.6817 |
| 2010's | 3 (7.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kokka, N; Olsen, RW; Sapp, DW; Witte, U | 1 |
| Davies, MF; Loew, GH; Maguire, PA; Onaivi, ES; Tsai, NF | 1 |
| Knaus, EE; Phillips, OA | 1 |
| Chang, YF; Chen, JS; Gao, XM | 1 |
| Fiakpui, CY; Knaus, EE; Namchuk, MN | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Calvo, D; Diaz, LE; Levi de Stein, M; Medina, JH; Paladini, AC; Peña, C; Wolfman, C | 1 |
| Danhof, M; Dingemanse, J; Hollander-Jansen, M; Langemeijer, MW | 1 |
| Chang, YF; Gao, XM | 1 |
| File, SE; Martin, IL; Wilks, L | 1 |
| Chang, YF; Chen, JS; Hargest, V | 1 |
| Chiu, TH; Rosenberg, HC; Tietz, EI | 1 |
| Chiu, TH; Duggan, JM; Rosenberg, HC; Tietz, EI | 1 |
| Avnimelech-Gigus, N; Feldon, J; Gavish, M; Myslobodsky, M | 1 |
| Chiu, TH; Ito, M; Rosenberg, HC | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Brown, C; Jones, B; Martin, I; Oakley, N | 1 |
| Bolger, GT; Cott, J; Mezey, E; Paul, SM; Skolnick, P; Weissman, BA | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Garattini, S; Mennini, T | 1 |
| Ito, K; Nose, T; Oki, K; Sukamoto, T | 1 |
| Beer, B; Lippa, AS; Meyerson, LR | 1 |
| Abbiati, A; Caccia, S; Cotecchia, S; Garattini, S; Gomez, A; Mennini, T | 1 |
| Chweh, AY; Swinyard, EA; Wolf, HH | 2 |
| Bymaster, FP; Lacefield, WB; Rathbun, RC; Wong, DT | 1 |
| Abbracchio, MP; Balduini, W; Cattabeni, F; Coen, E; Lombardelli, G; Peruzzi, G | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Battista De Sarro, G; Chimirri, A; De Sarro, A; Gitto, R; Grasso, S; Zappalà, M | 1 |
| Bruni, G; Corti, P; Massarelli, P; Pellerano, C; Romeo, MR; Savini, L | 1 |
| Chimirri, A; DeSarro, A; DeSarro, GB; Grasso, S; Zappalà, M | 1 |
| Cauley, RK; Chang, YF; Gao, XM; Wang, Y | 1 |
| Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF | 1 |
| Nakamoto, Y; Shiotani, T; Watabe, S; Yoshii, M | 1 |
| Ackermann, RF; Engel, J; Rocha, L | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Walsh, LA; Zhao, TJ | 1 |
| Bandyopadhyay, S; Beer, B; Czobor, P; Farb, DH; Gibbs, TT; Gravielle, M; Kostakis, E; Lippa, A; Russek, SJ; Skolnick, P; Stark, J | 1 |
| Fahey, JM; Grassi, JM; Greenblatt, DJ; Reddi, JM | 1 |
| Bruno-Blanch, LE; Higgs, J; Mangialavori, IC; Marder, M; Pastore, V; Wasowski, C | 1 |
| Liang, J; Lindemeyer, AK; Liu, Z; Olsen, RW; Shao, XM; Shao, Y; Tao, Y; Wallner, M | 1 |
| Botelho, P; Cunha, JM; de Zorzi, VN; Della-Pace, ID; do Nascimento, PS; Fighera, MR; Furian, AF; Gerbatin, RR; Hoffmann, MS; Kegler, A; Neto, JBT; Oliveira, MS; Royes, LFF; Silva, LFA | 1 |
2 review(s) available for pentylenetetrazole and flunitrazepam
| Article | Year |
|---|---|
Benzodiazepine receptors': correlation with pharmacological responses in living animals.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Kinetics; Muscle Relaxation; Pentylenetetrazole; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Molecular substrates of anxiety: clues from the heterogeneity of benzodiazepine receptors.
Topics: Aging; Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Chemical Phenomena; Chemistry, Physical; Flunitrazepam; Humans; Muscles; Pentylenetetrazole; Pyridazines; Receptors, Drug; Receptors, GABA-A; Tissue Distribution; Triazoles | 1982 |
1 trial(s) available for pentylenetetrazole and flunitrazepam
| Article | Year |
|---|---|
Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.
Topics: Adult; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety Disorders; Behavior, Animal; Conditioning, Operant; Diazepam; Double-Blind Method; Flunitrazepam; Germany; Humans; Oocytes; Patch-Clamp Techniques; Pentylenetetrazole; Pyrimidines; Rats; Receptors, GABA-A; Saimiri; Tritium; Xenopus laevis | 2005 |
38 other study(ies) available for pentylenetetrazole and flunitrazepam
| Article | Year |
|---|---|
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; Electroshock; Ethanol; Female; Flunitrazepam; Male; Muscimol; Orchiectomy; Ovariectomy; Pentylenetetrazole; Pregnanediones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sex Characteristics | 1992 |
Comparison of behavioral and central BDZ binding profile in three rat lines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Binding, Competitive; Body Temperature; Eating; Flumazenil; Flunitrazepam; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Species Specificity | 1992 |
Synthesis and anticonvulsant activity of 3-(3'-trifluoromethylphenoxy)-pyridines and -dihydropyridines.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Dihydropyridines; Electroshock; Flunitrazepam; In Vitro Techniques; Mice; Pentylenetetrazole; Pyridines; Rats; Receptors, GABA-A | 1991 |
Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Flunitrazepam; Lysine; Male; Membranes; Mice; Pentylenetetrazole; Seizures | 1991 |
Synthesis and anticonvulsant activity of 3-alkoxycarbonylaminomethylcarbonylamino-4-benzoylpyridines .
Topics: Animals; Anticonvulsants; Binding, Competitive; Biotransformation; Brain; Electroshock; Flunitrazepam; Male; Mice; Pentylenetetrazole; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1990 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties.
Topics: Animals; Anticonvulsants; Binding, Competitive; Flavonoids; Flunitrazepam; Mass Spectrometry; Mice; Pentylenetetrazole; Plant Extracts; Radioligand Assay; Receptors, GABA-A; Seizures | 1990 |
Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats.
Topics: Animals; Anticonvulsants; Central Nervous System; Chromatography, Gas; Flunitrazepam; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Temperature | 1989 |
Enhancement of benzodiazepine receptor binding by L-lysine is chloride-dependent and due to increase in binding affinity.
Topics: Animals; Cattle; Chlorides; Flunitrazepam; In Vitro Techniques; Kinetics; Lysine; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes | 1989 |
Evidence of strain differences in GABA-benzodiazepine coupling.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Male; Mice; Mice, Inbred Strains; Oxazepam; Pentylenetetrazole; Receptors, GABA-A; Seizures; Species Specificity | 1987 |
Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.
Topics: Animals; Biological Transport; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Lysine; Male; Mice; Pentylenetetrazole; Pipecolic Acids; Receptors, GABA-A; Seizures | 1988 |
Tolerance to the anticonvulsant action of benzodiazepines. Relationship to decreased receptor density.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Diazepam; Drug Tolerance; Flunitrazepam; Male; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Non-uniformity of tolerance to the actions of benzodiazepine agonists.
Topics: Animals; Anti-Anxiety Agents; Brain; Drug Tolerance; Flunitrazepam; Flurazepam; In Vitro Techniques; Pentylenetetrazole; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1988 |
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepam; Pentylenetetrazole; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1986 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
In vivo determination of efficacy of pyrazoloquinolinones at the benzodiazepine receptor.
Topics: Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Flunitrazepam; Male; Mice; Pentylenetetrazole; Pyrazoles; Receptors, GABA-A | 1984 |
Differential regulation of 'central' and 'peripheral' benzodiazepine binding sites in the rat olfactory bulb.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cerebellum; Convulsants; Flunitrazepam; Kinetics; Male; Olfactory Bulb; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
In vitro and ex vivo inhibition by flutoprazepam of [3H]flunitrazepam binding to mouse brain receptors.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Binding, Competitive; Brain; Flunitrazepam; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred Strains; Pentylenetetrazole; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Flunitrazepam; Kinetics; Male; Membranes; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1982 |
Pentylenetetrazol may discriminate between different types of benzodiazepine receptors.
Topics: Animals; Binding Sites; Brain; Flunitrazepam; Male; Mice; Pentylenetetrazole; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution | 1983 |
Enhanced binding of radioligands to receptors of gamma-aminobutyric acid and benzodiazepine by a new anticonvulsive agent, LY81067.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Triazines | 1983 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice.
Topics: Adenosine; Animals; Benzodiazepines; Flunitrazepam; Male; Mice; Pentylenetetrazole; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Tritium | 1984 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Solvents; Time Factors | 1993 |
Structure-activity relationships in thienodiazepine and benzodiazepine derivatives.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Clobazam; Flunitrazepam; Lipids; Male; Membranes; Mice; Mice, Inbred DBA; Pentylenetetrazole; Rats; Seizures; Structure-Activity Relationship | 1994 |
Pyrazolo[4,3-c]quinolines, synthesis and specific inhibition of benzodiazepine receptor binding. Note II.
Topics: Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Female; Flunitrazepam; Mice; Pentylenetetrazole; Pyrazoles; Quinolines; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1993 |
Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Body Temperature; Flumazenil; Flunitrazepam; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Mice, Inbred DBA; Molecular Weight; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Thiazoles | 1993 |
Chronic L-lysine develops anti-pentylenetetrazol tolerance and reduces synaptic GABAergic sensitivity.
Topics: Animals; Binding, Competitive; Brain; Chloride Channels; Chromatography, High Pressure Liquid; Drug Tolerance; Flunitrazepam; Injections, Intraperitoneal; Lysine; Male; Membrane Proteins; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures; Time Factors | 1993 |
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
Topics: Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Flunitrazepam; GABA Agonists; GABA Antagonists; Molecular Conformation; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Quinoxalines; Rats; Receptors, GABA-A | 1996 |
Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Cell Fractionation; Convulsants; Epilepsy; Flunitrazepam; GABA-A Receptor Agonists; Isoquinolines; Membrane Proteins; Mice; Mice, Mutant Strains; Mitochondria; Pentylenetetrazole; Prosencephalon; Receptors, GABA-A; Tritium | 1996 |
Chronic and single administration of pentylenetetrazol modifies benzodiazepine receptor-binding: an autoradiographic study.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Convulsants; Densitometry; Flunitrazepam; Male; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 1996 |
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with No effect on benzodiazepine binding site density.
Topics: Animals; Autoradiography; Brain; Down-Regulation; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1999 |
Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses.
Topics: Animals; Anticonvulsants; Binding, Competitive; Convulsants; Dose-Response Relationship, Drug; Flunitrazepam; Hypnotics and Sedatives; Lorazepam; Male; Mice; Motor Activity; Pentylenetetrazole; Pyridines; Receptors, Drug; Receptors, GABA-A; Seizures; Zolpidem | 2006 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazepam; Glutathione; Hindlimb Suspension; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Trimethadione; Veratrine | 2014 |
Flavonoids isolated from Tibetan medicines, binding to GABA
Topics: Animals; Anticonvulsants; Arenaria Plant; Asteraceae; China; Flavonoids; Flunitrazepam; GABA-A Receptor Antagonists; Male; Medicine, Tibetan Traditional; Mice; Mice, Inbred C57BL; Molecular Structure; Pentylenetetrazole; Plant Extracts; Prospective Studies; Receptors, GABA-A; Seizures | 2018 |
Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats.
Topics: Animals; Brain Injuries, Traumatic; Brain Waves; CA3 Region, Hippocampal; Cell Death; Creatine; Epilepsy, Post-Traumatic; Flunitrazepam; GABAergic Neurons; Glutamate Decarboxylase; Male; Neuroprotective Agents; Pentylenetetrazole; Radioligand Assay; Rats; Seizures; Time Factors; Tritium | 2019 |