pentylenetetrazole has been researched along with diazepam in 390 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 202 (51.79) | 18.7374 |
| 1990's | 66 (16.92) | 18.2507 |
| 2000's | 59 (15.13) | 29.6817 |
| 2010's | 45 (11.54) | 24.3611 |
| 2020's | 18 (4.62) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, DE; Marriott, JG; Poschel, BP | 1 |
| Golovenko, NIa; Zin'kovskii, VG | 1 |
| de Angelis, L; Traversa, U; Vertua, R | 2 |
| Javid, MJ; Stone, WE | 1 |
| Lal, H; Miksic, S; Shearman, GT | 1 |
| Costa, E; Guidotti, A; Mao, CC; Suria, A | 1 |
| Dinnedahl, V; Gumulka, SW; Opmeer, FA; Schönhöfer, PS | 1 |
| Ferrendelli, JA; Rubin, EH | 1 |
| Fukushima, H; Nakamura, M | 1 |
| Jones, DJ; Medina, MA; Palmer, GC; Stavinoha, WB | 1 |
| Garibova, TL; Klygul', TA; Vikhliaev, IuI | 1 |
| Costa, E; Guidotti, A; Mao, CC | 1 |
| Goodwin, FK; Marangos, PJ; Paul, SM; Skolnick, P | 1 |
| Decsi, L; Nagy, J | 1 |
| Goodwin, FK; Marangos, PJ; Parma, AM; Paul, SM; Skolnick, P; Syapin, P | 1 |
| Anhut, H; Hertting, G; Steinhauer, HB | 1 |
| Banerjee, U; Yeoh, PN | 1 |
| Lippa, AS; Regan, B | 1 |
| Greenlee, D; Olsen, RW; Ticku, MK; Van Ness, PC | 1 |
| Paul, SM; Skolnick, P | 1 |
| Faugier-Grimaud, S | 1 |
| Bantutova, I; Koburova, K; Ovcharov, R | 1 |
| Anderson, RJ; Raines, A | 1 |
| Bigler, ED; Eidelberg, E | 1 |
| Kokka, N; Olsen, RW; Sapp, DW; Witte, U | 1 |
| Lin, WC; Watanabe, K; Yano, S | 2 |
| Boone, MS; Emmett-Oglesby, MW; Pugh, SL | 1 |
| al-Hader, A; Hasan, M; Hasan, Z | 1 |
| Carey, GJ; Costall, B; Domeney, AM; Jones, DN; Naylor, RJ | 1 |
| Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA | 1 |
| Beal, MF; MacGarvey, U; Miller, J; Vécsei, L | 1 |
| Georgiev, VP; Kambourova, TS; Lazarova, MB | 1 |
| Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M | 1 |
| Diamantis, W; Gels, M; Gordon, R; Sofia, RD | 1 |
| Becker, A; Grecksch, G; Matthies, H; Ruethrich, HL; Schneider, R | 1 |
| Bhattacharya, SK; Mitra, SK | 1 |
| Fukuda, N; Wada, T | 2 |
| Oles, RJ; Singh, L; Tricklebank, MD | 1 |
| Hirai, Y; Kuraishi, Y; Minami, M; Nakai, S; Satoh, M; Yamaguchi, T | 1 |
| Coper, H; Jänicke, B | 1 |
| Enginar, N; Eroğlu, L | 1 |
| Bhattacharya, SK; Clow, A; Glover, V; Halket, J; Przyborowska, A; Sandler, M | 1 |
| Dudkin, AO | 1 |
| Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD | 1 |
| Fredow, G; Löscher, W | 1 |
| Akbar, GK; Shanmugasundaram, ER; Shanmugasundaram, KR | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Dahl, CB; Flaten, MA; Gråwe, RW; Haug, T | 1 |
| Bittle, BK; Jaimovich, DG; Noorani, PA; Osborne, JS; Shabino, CL | 1 |
| Teo, WL; Wong, PT | 1 |
| Genkova-Papasova, M; Lazarova-Bakarova, M; Petkov, VV | 1 |
| Hijzen, TH; Slangen, JL; Woudenberg, F | 1 |
| Hill, JL; Insel, TR; Mayor, RB | 1 |
| Schneider, HH; Stephens, DN; Weidmann, R; Zimmermann, L | 1 |
| Emmett-Oglesby, MW; Harris, CM; Lal, H | 1 |
| Eigyo, M; Matsushita, A; Murata, S; Shindo, H; Takada, S | 1 |
| Aranko, K; Dingemanse, J; File, SE; Johnston, AL | 1 |
| Antelman, SM; Edwards, DJ; Knopf, S; Kocan, D | 1 |
| Boyland, P; Cox, A; Feely, M; Gent, JP; Picardo, A | 1 |
| Nagatani, T; Sugihara, T; Ueki, S; Yamamoto, T | 1 |
| Chang, YF; Chen, JS; Hargest, V | 1 |
| Golovenko, NIa; Zhuk, OV; Zin'kovskiĭ, VG | 1 |
| Chapouthier, G; Potier, MC; Prado de Carvalho, L; Rossier, J; Venault, P | 1 |
| Chiu, TH; Rosenberg, HC; Tietz, EI | 1 |
| Bertolissi, M; de Angelis, L; Della Loggia, R; Nardini, G; Traversa, U; Vertua, R | 1 |
| Grützner, M; Meldrum, BS; Schneider, C; Stephens, DN; Weidmann, R | 1 |
| Biziere, K; Keane, PE; Morre, M; Simiand, J | 1 |
| Bender, AS; Hertz, L | 1 |
| Kryzhanovskiĭ, GN; Shandra, AA | 1 |
| Ibba, M; Mennini, T; Testa, R | 1 |
| Bennett, DA; Bernard, PS; Liebman, JM; Pastor, G; Yokoyama, N | 1 |
| Bourn, WM; Garrett, RL | 1 |
| Vellucci, SV; Webster, RA | 2 |
| Fukuda, H; Goto, M; Morishita, S | 3 |
| Creveling, CR; Daly, JW; Hollingsworth, EB; Lewandowski, G; Waters, JA | 1 |
| Biggio, G; Corda, MG | 1 |
| Kulkarni, SK; Kunchandy, J | 1 |
| Cohen, DR; Curran, T; Hempstead, JL; Morgan, JI | 1 |
| Antelman, SM; Caggiula, AR; Edwards, DJ; Knopf, S; Kocan, D; Lysle, DT | 1 |
| Hönack, D; Löscher, W; Nolting, B | 1 |
| Bentley, M; Feely, M; Gent, JP; Haigh, JR | 1 |
| Katzman, NJ; Shannon, HE | 1 |
| Emmett-Oglesby, MW; Harris, CM; Lal, H; Robinson, NG | 1 |
| Laporte, AM; Soubrié, P; Thiébot, MH | 1 |
| Igarashi, T; Kitagawa, H; Ohmori, S; Okiyama, M; Ueno, K | 1 |
| Emmett-Oglesby, MW; Harris, CM; Lal, H; Mathis, DA | 1 |
| Barrett, RJ; Smith, RL | 1 |
| Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA | 1 |
| Pappas, BA; Ryan, CL; Smythe, JW | 1 |
| Hiltunen, AJ; Järbe, TU | 1 |
| Antelman, SM; Edwards, DJ; Knopf, S; Kocan, D; Nemeroff, CB; Ritchie, JC | 1 |
| Balm, M; Coyle, JT; Markl, A; Zaczek, R | 1 |
| Angelo, H; Bredgaard Sørensen, M; Carl, P; Høgskilde, S; Nielsen, JW | 1 |
| Georgieva, Zh; Ognianov, I; Ovcharov, R; Uzunov, P | 1 |
| Davidson, TL; Lucki, I | 1 |
| Albertson, TE | 1 |
| Bareggi, SR; Bianchi, M; Mantegazza, P; Panerai, AE; Rovati, LC | 1 |
| Benjamin, D; Harris, CM; Lal, H | 1 |
| Gallager, DW; Gonsalves, SF | 1 |
| Rock, DM; Taylor, CP | 1 |
| Böke-Kuhn, K; Danneberg, P; Lehr, E | 1 |
| Kaneda, H; Kaneto, H; Kawatani, S | 1 |
| Dolin, SJ; Halsey, MJ; Little, HJ | 1 |
| Lathers, CM; McNamara, RM; Spivey, WH; Unger, HD | 1 |
| Longo, VG; Sagratella, S | 1 |
| Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Makul'kin, RF; Shandra, AA | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Brown, C; File, SE; Greenblatt, DJ; Martin, IL | 1 |
| File, SE; Pellow, S; Wilks, L | 1 |
| Higashio, T; Inukai, T; Nakao, K | 1 |
| Jaffe, R; Rapoport, AM; Schlaifer, LW | 1 |
| Garattini, S; Guaitani, A; Marcucci, F; Martelli, P; Mussini, E | 1 |
| Gogerty, JH; Iorio, LC; Ryan, EA | 1 |
| Bauer, EW; Da Vanzo, JP; Heilman, RD | 1 |
| Asami, Y; Hirohashi, T; Inaba, S; Otsuka, M; Yamamoto, H | 1 |
| Ferrini, R; Miragoli, G; Taccardi, B | 1 |
| Killam, EK; Killam, KF; Naquet, R | 1 |
| Bergamasco, B | 2 |
| Cossette, A; Gastaut, H; Naquet, R | 3 |
| Ellington, A; Torres, F | 1 |
| Browne, TR; Penry, JK | 1 |
| Chen, G; Ensor, CR; McCarthy, DA; Poschel, BP | 1 |
| Gillette, JR; Stripp, B | 1 |
| Chusid, JG; Kopeloff, LM | 2 |
| Brodie, BB; Koppanyi, T; Maling, HM; Saul, W | 1 |
| Consolo, S; Garattini, S; Ladinsky, H; Peri, G | 2 |
| Fryer, RI; Walser, A | 1 |
| Izquierdo, I | 1 |
| Barnett, A; Fiedler, EP; Goldstein, J; Taber, RI | 1 |
| Booker, HE; Celesia, GG; Sato, S | 1 |
| Kirsten, EB; Schoener, EP | 1 |
| Thigpen, CH | 2 |
| Airoldi, L; Garattini, S; Guaitani, A; Marcucci, F; Mussini, E | 1 |
| Besson, JM; Decaud-Gasarabwe, J; Menétrey, D | 1 |
| Costa, E; Doteuchi, M | 1 |
| De Souza, NJ; Desai, PD; Dohadwalla, AN; Kohl, H | 1 |
| Müller, D; Schulz, H | 1 |
| Gylys, JA; Hillyard, IW; Robichaud, RC; Sledge, KL | 1 |
| Fromm, GH; Killian, JM; Sanchez, F | 1 |
| Inoki, R; Iwatsubo, K; Shigenaga, Y | 1 |
| Fanelli, R; Garattini, S; Guaitani, A; Marcucci, F; Mussini, E | 1 |
| Castillo de Bonnevaux, S; Díez Altares, MC | 1 |
| Babbini, M; De Marchi, F; Montanaro, N; Strocchi, P; Torrielli, MV | 1 |
| Schaumann, W; Wohlfarth-Ribbentrop, A | 1 |
| Garattini, S; Marcucci, F; Mussini, E | 1 |
| Fanelli, R; Garattini, S; Marcucci, F; Mussini, E | 1 |
| Christmas, AJ; Maxwell, DR | 1 |
| Carbone, JJ; Cheripko, JA; Coutinho, CB | 1 |
| Coeugniet, E; Dobrescu, D | 1 |
| Hudson, RD; Wolpert, MK | 1 |
| Adronati, SA; Klygul', TA; Prokudin, VN; Vikhliaev, IuI | 1 |
| Carrillo, L; de Bonnevaux, SC | 1 |
| Colley, B; Spehlman, R | 1 |
| Straw, RN | 1 |
| Denhoff, E; Shammas, E | 1 |
| Garattini, S; Guaitani, A; Kvetina, J; Marcucci, F; Mussini, E | 1 |
| Marcucci, F; Mussini, E | 1 |
| Choksey, HK; Doctor, RB; Jindal, MN; Kelkar, VV | 1 |
| Arrigo, A; Mille, T; Pastorino, G | 1 |
| Arrigo, A; Jann, G; Tonali, P | 1 |
| Castellion, AW; Swinyard, EA | 1 |
| Shapiro, EP; Taber, RI; Topliss, JG | 1 |
| Boudouresques, J; Dubois, D; Gastaut, H; Lob, H; Roger, J; Toga, M | 1 |
| Kehr, W; Shearman, GT; Stephens, DN | 1 |
| Brown, C; Jones, B; Martin, I; Oakley, N | 1 |
| File, SE | 3 |
| Brown, CL; Martin, IL | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Dunn, R; Fielding, S; Kruse, H; Lal, H; Shearman, GT; Theurer, K | 1 |
| Jones, BJ; Oakley, NR | 1 |
| Kosoĭ, MIu | 1 |
| Ballabio, M; Caccia, S; Carli, M; Garattini, S; Samanin, R | 1 |
| Fryer, RI; Leimgruber, W; Trybulski, EJ | 1 |
| Barker, SA; Cain, M; Cook, JM; Crawley, JN; Guzman, F; Paul, SM; Rice, KC; Skolnick, P; Weber, RW | 1 |
| Garattini, S; Mennini, T | 1 |
| Benjamin, LE; Fryer, RI; Gilman, NW; Trybulski, EJ | 1 |
| Gherezghiher, T; Lal, H | 1 |
| Miyamoto, M; Nagawa, Y; Saji, Y; Shintani, M | 1 |
| Gonzalez, JP; McCulloch, AJ; Nicholls, PJ; Sewell, RD; Tekle, A | 1 |
| Zetler, G | 1 |
| Hirsch, JD; Tenen, SS | 1 |
| Lapin, IP | 3 |
| Marangos, PJ; Paul, SM; Skolnick, P | 1 |
| Petersen, EN | 1 |
| File, SE; Green, AR; Nutt, DJ; Vincent, ND | 1 |
| Chapouthier, G; de Carvalho, LP; Grecksch, G; Rossier, J; Venault, P | 1 |
| Ballabio, M; Caccia, S; Garattini, S; Guiso, G; Reginato, R | 1 |
| Elmesallamy, F; Emmett-Oglesby, M; Lal, H; Lewis, M; Spencer, D | 1 |
| Coleman, JB; Cox, C; Schuler, R; Wood, RW | 1 |
| Emmett-Oglesby, MW; Lal, H; Lewis, MW; Spencer, DG | 1 |
| Cavalheiro, EA; Chapouthier, G; Dodd, RH; Grecksch, G; Prado de Carvalho, L; Rossier, J | 1 |
| Frey, HH; Philippin, HP; Scheuler, W | 1 |
| Baimbridge, KG; Miller, JJ | 1 |
| Shibata, K; Shibata, S; Ueki, S; Watanabe, S; Yamamoto, T | 1 |
| Fukuda, T; Tsumagari, T | 1 |
| Pappas, BA; Walsh, P | 1 |
| Benjamin, L; Fryer, RI; Trybulski, EJ; Vitone, S; Walser, A | 1 |
| Syapin, PJ | 1 |
| Elmesallamy, F; Emmett-Oglesby, MW; Lal, H; Spencer, DG | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, W | 1 |
| Frey, HH; Löscher, W | 1 |
| Albertson, TE; Joy, RM; Stark, LG | 1 |
| Emmett-Oglesby, MW; Lal, H; Wurst, M | 1 |
| Angioi, RM; Bonetti, EP; Cumin, R; Haefely, WE; Möhler, H; Pieri, L; Polc, P | 1 |
| Lal, H; Shearman, GT | 1 |
| Albertson, TE; Lakin, ML; Peterson, SL; Stark, LG; Winters, WD | 1 |
| Mattson, M; Paul, SM; Rice, KC; Skolnick, P; Williams, EF | 1 |
| Albertson, TE; Peterson, SL; Stark, LG | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L | 1 |
| Billimoria, RB; Naik, PR; Satoskar, RS | 1 |
| Bluth, R | 1 |
| Alberton, TE; Bowyer, JF | 1 |
| George, B; Kulkarni, SK | 1 |
| Carey, MP; Fry, JP | 1 |
| Hönack, D; Löscher, W | 1 |
| Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Akai, T; Nakada-Kometani, Y; Ozawa, M; Sugimachi, K; Yamaguchi, M | 1 |
| Melchior, CL; Ritzmann, RF | 1 |
| Ramsey-Williams, VA; Rosenberg, HC; Wu, Y | 1 |
| Glebov, RN; Karpova, MN; Kruglikov, RI; Pankov, OIu; Zhulin, VV | 1 |
| Becker, A; Grecksch, G; Matthies, H | 1 |
| Costentin, J; Panissaud, C; Simon, P | 1 |
| Belknap, JK; Crabbe, JC; Merrill, CM | 1 |
| Peterson, SL | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Leuschner, J; Müller, J; Rudmann, M | 1 |
| Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD | 1 |
| Avenet, P; Depoortere, H; Granger, P; Itier, V; Perrault, G; Scatton, B | 1 |
| Bottlaender, M; Brouillet, E; Fournier, D; Fuseau, C; Mazière, M; Schmid, L | 1 |
| Lin, WC | 1 |
| Berton, O; Chaouloff, F; Mormède, P; Ramos, A | 1 |
| Misawa, M; Suzuki, T; Tsuda, M | 1 |
| Becker, A; Grecksch, GA; Tiedge, A | 1 |
| Carter, DB; Franklin, SR; Jacobsen, EJ; Needham, LM; Sethy, VH; Tang, AH; Von Voigtlander, PF | 1 |
| Hu, XJ; Ticku, MK | 1 |
| de Pádua Carobrez, A; De Souza, MM; Schenberg, LC | 1 |
| Stephens, DN; Ward, BO | 1 |
| Dunworth, SJ; Stephens, DN | 1 |
| Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y | 1 |
| Jenck, F; Martin, JR; Moreau, JL; Pieri, L | 1 |
| da Silva, LF; Elisabetsky, E; Pereira, P | 1 |
| Garibova, TL; Kraĭneva, VA; Val'dman, EA; Voronina, TA | 1 |
| Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E | 1 |
| Czuczwar, SJ; Kleinrok, Z; Klonowski, P; Tutka, P | 1 |
| Misawa, M; Shimizu, N; Soma, M; Suzuki, T; Tsuda, M | 1 |
| Gupta, YK; Malhotra, J | 1 |
| Gatch, MB; Jung, ME; Lal, H; Wallis, CJ | 1 |
| Bijak, M; Chojnacka-Wójcik, E; Czuczwar, SJ; Kroczka, B; Kłodzińska, A; Pilc, A; Swiader, M | 1 |
| Adam, G; Cesura, AM; Dautzenberg, FM; Jenck, F; Kilpatrick, G; Kolczewski, S; Lundstrom, K; Martin, JR; Moreau, JL; Ouagazzal, AM; Poli, SM; Roever, S; Wichmann, J | 1 |
| Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM | 1 |
| Nogueira, E; Vassilieff, VS | 1 |
| Becker, A; Grecksch, G; Höllt, V; Thiemann, W | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z | 1 |
| Reddy, DS; Rogawski, MA | 2 |
| Cornford, EM; Landaw, EM; Nguyen, EV | 1 |
| Lilly, SM; Tietz, EI | 1 |
| do Vale, TG; Matos, FJ; Silva, CM; Viana, GS | 1 |
| Crestani, F; Martin, JR; Möhler, H; Rudolph, U | 1 |
| Bazyan, AS; Glebov, RN; Karpova, MN; Klishina, NY; Zhulin, VV | 1 |
| Depoortere, R; Jung, ME; Oglesby, MW | 1 |
| Gupta, YK; Srivastava, AK | 1 |
| Groenink, L; Maes, RA; Olivier, B; Oosting, RS; Pattij, T; van der Gugten, J | 1 |
| Akamatsu, N; Tsuji, S | 1 |
| Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H | 1 |
| Akbarzadeh, T; Khoshnoud, MJ; Shafaghi, B; Shafiee, A; Tabatabai, SA | 1 |
| Jelen, P; Soltysik, S; Zagrodzka, J | 1 |
| Bale, AS; Balster, RL; Wiley, JL | 1 |
| Ahmadiani, A; Mandgary, A; Sayyah, M | 1 |
| Crabbe, JC; Finn, DA; Kliethermes, CL | 1 |
| Li, CL; Song, HR; Wang, YL; Wu, CF; Yang, JY; Zhang, HF | 1 |
| SIGG, EB; WARNER, CL; YEN, HC | 1 |
| BANZIGER, RF | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Hosseinzadeh, H; Parvardeh, S | 1 |
| Kalueff, AV; Tuohimaa, P | 1 |
| Kenunen, OG; Kozlovskiĭ, BL; Prakh'e, IV | 1 |
| Baier, H; Baraban, SC; Castro, PA; Taylor, MR | 1 |
| Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S | 1 |
| Bandyopadhyay, S; Beer, B; Czobor, P; Farb, DH; Gibbs, TT; Gravielle, M; Kostakis, E; Lippa, A; Russek, SJ; Skolnick, P; Stark, J | 1 |
| Ahadian, A; Faizi, M; Khojastehpoor, HR; Shafaghi, B; Shafiee, A; Tabatabai, SA; Zanganeh, V; Zarghi, A | 1 |
| Ahmad, FJ; Ali, A; Pillai, KK; Vohora, D | 1 |
| Fidecka, S; Listos, J; Malec, D | 1 |
| Kenunen, OG; Kozlovskii, VL; Prakh'e, IV | 1 |
| Chávez, M; Domínguez, F; González, M; González-Trujano, ME; Martínez, AL; Orozco, S; Salgado, H | 1 |
| Aimoto, T; Araki, H; Hidaka, N; Suemaru, K | 1 |
| Chojnacka-Wójcik, E; Nikiforuk, A; Wesołowska, A | 1 |
| Andreatini, R; Da Cunha, C; Vargas, KM | 1 |
| Dhir, A; Kulkarni, SK; Naidu, PS | 1 |
| Crabbe, JC; Kliethermes, CL | 1 |
| Atack, JR; Bull, S; Dawson, GR; Fradley, RL; Garrett, EM; Goodacre, SC; Guscott, MR; Hallett, DJ; Newman, RJ; O'Meara, GF; Reynolds, DS; Rosahl, TW; Wafford, KA; Whiting, PJ | 1 |
| Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR | 1 |
| Kalueff, AV; Keisala, T; Minasyan, A; Tuohimaa, P | 1 |
| Nassiri-Asl, M; Shariati-Rad, S; Zamansoltani, F | 2 |
| O'Brien, GS; Plotnikoff, NP | 1 |
| Alves, PB; Antoniolli, AR; Blank, AF; Bonjardim, LR; Leite, BS; Lessa, NM; Quintans-Júnior, LJ; Santos, MR; Souza, TT | 1 |
| Pericić, D; Strac, DS; Vlainić, J | 1 |
| Flores, P; Lopez-Crespo, G; López-Grancha, M; Sanchez-Amate, MC | 1 |
| Fidecka, S; Listos, J; Talarek, S | 1 |
| Bailabar, T; Bum, EN; Hiana, IR; Moto, FC; Nkainsa, LA; Rakotonirina, A; Rakotonirina, SV; Seke Etet, PF; Seyni, P; Taiwe, GS | 1 |
| Pericić, D; Vlainić, J | 1 |
| Assreuy, AM; Bezerra, EH; Cavada, BS; de Sousa, FC; Lima, SR; Lobato, Rde F; Patrocínio, MC; Santi-Gadelha, T; Soares, PM; Vasconcelos, GS; Vasconcelos, SM | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Moto, FC; Ngo Bum, E; Ngoupaye, GT; Nkantchoua, GC; Pelanken, MM; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS | 1 |
| Dehpour, AR; Gholipour, T; Jabbarzadeh, A; Nezami, BG; Rasouli, A; Riazi, K; Sharifzadeh, M | 1 |
| Bhattacharya, SK; Katiyar, C; Kumar, A; Singh, RS | 1 |
| Barbosa, FF; Fernandes, VS; Godinho, M; Munguba, H; Nascimento, EB; Ribeiro, AM; Silva, RH | 1 |
| Araki, H; Kawasaki, H; Ochi, R; Suemaru, K | 1 |
| Godlevskii, LS; Kobolev, EV; Kresyun, VI | 1 |
| Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M | 1 |
| Badami, S; Mahendran, S; Thippeswamy, BS; Veerapur, VP | 1 |
| Anitha, T; Gajera, K; Jayaraman, R; Joshi, VD; Ladani, K; Manisenthil, KT; Palei, NN | 1 |
| Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S | 1 |
| Arora, T; Banerjee, BD; Joshi, V; Mahajan, P; Mediratta, PK; Mehta, AK; Mehta, KD; Rathor, N; Sharma, AK; Sharma, KK | 1 |
| France, CP; Gerak, LR | 1 |
| Ibi, D; Itohara, S; Kamei, H; Koike, H; Mizoguchi, H; Nabeshima, T; Nakade, J; Sato, J; Sawada, M; Someya, E; Tachibana, M; Takuma, K; Yamada, K | 1 |
| Chebib, M; Gavande, N; Hanrahan, JR; Johnston, GA; Karim, N; Wellendorph, P | 1 |
| Can, OD; Ozkay, UD | 1 |
| Chagas, PM; Gai, BM; Nogueira, CW; Roehrs, JA; Souza, AC; Wilhelm, EA | 1 |
| Gmiro, VE; Serdiuk, SE | 1 |
| Bansal, R; Chauhan, P; Sharma, R | 1 |
| Mori, T; Shibasaki, M; Shimizu, N; Suzuki, T | 1 |
| Baggio, S; Battastini, AM; Calcagnotto, ME; Campos, MM; de Oliveira, DL; Dias, RD; Leite, CE; Moro, L; Mussulini, BH; Rico, EP; Rosemberg, DB; Souza, TM; Zenki, KC | 1 |
| Andjus, PR; Ilić, TV; Ostojić, ZS; Vesković, SM | 1 |
| Mendes-Gomes, J; Nunes-de-Souza, RL; Rico, JL; Rodgers, RJ; Sorregotti, T | 1 |
| Drozdova, GA; Godlevsky, LS; Kobolev, EV; Mustyatsa, VF; Polyasnyi, VA | 1 |
| Beleboni, RO; Cunha, AO; Dos Santos, WF; Gelfuso, EA; Liberato, JL; Lopes, NP; Mortari, MR | 1 |
| Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM | 1 |
| Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E | 1 |
| Costa, AP; de Lima, TC; de Pieri, CH; dos Santos, AA; Duarte, FS; Duzzioni, M; Farina, M; Hoeller, AA; Leme, LR; Naime, AA; Santos, EC | 1 |
| da Silva Junior, PI; dos Santos, WF; Godoy, LD; Liberato, JL | 1 |
| Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA | 1 |
| Ahmad, A; Vohora, D | 1 |
| Costa, EA; Da Rocha, FF; Fajemiroye, JO; Florentino, IF; Galdino, PM; Ghedini, PC; Polepally, PR; Zjawiony, JK | 1 |
| Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T | 1 |
| FallahHuseini, H; Ghaznavi, H; Gholamine, B; Hosseinzadeh, A; Mehrzadi, S; Sadr, S; Shahbazi, A | 1 |
| Almeida-Souza, TH; Goes, TC; Teixeira-Silva, F | 1 |
| Hernández-Medel, Mdel R; Mora-Pérez, A | 1 |
| Díaz, FV; Rasgado, LA; Reyes, GC | 1 |
| Löscher, W; Töllner, K; Twele, F | 1 |
| Coelho, VR; da Silva, LL; de Souza, LP; Papke, DK; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Vieira, CG | 1 |
| Fotouhi, M; Keshavarz, M; Rasti, A | 1 |
| Adongo, DW; Mante, PK; Woode, E | 1 |
| Erfanparast, A; Henareh-Chareh, F; Tamaddonfard, E | 1 |
| Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A | 1 |
| Kotlińska, J; Listos, J; Orzelska-Gorka, J; Serefko, A; Talarek, S | 1 |
| Boi, M; Corda, MG; Fernández Teruel, A; Giorgi, O; Piludu, MA; Piras, G; Sanna, F | 1 |
| da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R | 1 |
| Arrifano, GPF; Carvalho, JCT; Crespo-López, ME; Farina, M; Lichtenstein, MP; Rogez, H; Souza-Monteiro, JR; Suñol, C | 1 |
| Barbosa, NV; Canzian, J; Dos Santos, MM; Fontana, BD; Loro, VL; Mello, CF; Mezzomo, NJ; Müller, TE; Rosemberg, DB; Ziani, PR | 1 |
| Bykov, VN; Drachkova, IM; Sarana, AM; Vengerovich, NG; Yudin, MA | 1 |
| Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF | 1 |
| Ahmad, G; Imran, I; Rashid, U; Rasool, N; Rizwan, K; Sadiq, A; Zahoor, AF; Zubair, M | 1 |
| Brito, ES; Campos, AR; Costa, AM; Dionisio, AP; Holanda, DKR; Iunes, MF; Moreira, RA; Ribeiro, PRV; Sousa, PHM; Wurlitzer, NJ | 1 |
| Aghamiri, H; Asgarpanah, J; Shafaroodi, H | 1 |
| da Silva, LS; de Oliveira, C; de Souza, A; Fregni, F; Pereira, P; Pflüger, P; Regner, GG; Scarabelot, VL; Ströher, R; Torres, ILS | 1 |
| Godlevsky, LS; Pervak, MP; Shandra, AA; Shandra, OO | 1 |
| Aguiar, GPS; Almeida, ER; Decui, L; Garbinato, C; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Schneider, SE; Siebel, AM | 1 |
| Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL | 1 |
| Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD | 1 |
| Kangi, S; Najimi, S; Rahimi, HR; Sabouri, S | 1 |
| Barbas, LAL; da Silva, TVN; Hamoy, M; Monserrat, JM; Sampaio, LA; Torres, MF | 1 |
| Aguiar, GPS; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Piato, A; Schneider, SE; Siebel, AM | 1 |
| Fantegrossi, WE; Wilson, CD; Zheng, F | 1 |
| Manna, SSS | 1 |
| Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR | 1 |
| Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR | 1 |
| Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE | 1 |
| Abula, T; Alberts, PSF; Lee, HJ; Raimondo, JV; Salile, SS; Stafford, GI | 1 |
| Abdolmaleki, A; Asadi, A; Hassanpour, H; Shayan, TK | 1 |
| Azevedo, JEC; de Araujo, DB; de Mello, VJ; Favacho Lopes, DC; Hamoy, AO; Hamoy, M; Martins Rodrigues, JC; Nascimento, CP; Silva, ALMD; Tiago, ACDS; Vieira, LR | 1 |
6 review(s) available for pentylenetetrazole and diazepam
| Article | Year |
|---|---|
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra | 1975 |
Putative endogenous ligands for the benzodiazepine receptor.
Topics: Animals; Benzodiazepines; Diazepam; Ligands; Neurons; Pentylenetetrazole; Protein Binding; Purines; Receptors, Drug; Xanthines | 1979 |
Stress and enhanced dopamine utilization in the frontal cortex: the myth and the reality.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzodiazepines; Diazepam; Dopamine; Electroshock; Frontal Lobe; Pentylenetetrazole; Restraint, Physical; Stress, Physiological | 1988 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Light; Myoclonus; Nitrazepam; Oxazepam; Pentylenetetrazole; Pregnancy; Seizures; Substance Withdrawal Syndrome | 1973 |
Benzodiazepine receptors': correlation with pharmacological responses in living animals.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Kinetics; Muscle Relaxation; Pentylenetetrazole; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
[Treatment of status epilepticus].
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electric Stimulation Therapy; Humans; Magnetics; Midazolam; Pentobarbital; Pentylenetetrazole; Phenytoin; Rats; Status Epilepticus | 2001 |
2 trial(s) available for pentylenetetrazole and diazepam
| Article | Year |
|---|---|
Observations on the discrepancy between the clinical and the laboratory effects of anti-petit mal drugs.
Topics: Action Potentials; Anticonvulsants; Chloralose; Clinical Trials as Topic; Diazepam; Epilepsy, Absence; Humans; Oxazoles; Pentylenetetrazole; Trigeminal Nerve; Trimethadione | 1967 |
Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.
Topics: Adult; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety Disorders; Behavior, Animal; Conditioning, Operant; Diazepam; Double-Blind Method; Flunitrazepam; Germany; Humans; Oocytes; Patch-Clamp Techniques; Pentylenetetrazole; Pyrimidines; Rats; Receptors, GABA-A; Saimiri; Tritium; Xenopus laevis | 2005 |
382 other study(ies) available for pentylenetetrazole and diazepam
| Article | Year |
|---|---|
Cognition-activating properties of 3-(Aryloxy)pyridines.
Topics: Animals; Cognition; Dose-Response Relationship, Drug; Male; Mice; Psychotropic Drugs; Pyridines; Structure-Activity Relationship | 1981 |
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred CBA; Nordazepam; Oxazepam; Pentylenetetrazole; Seizures; Time Factors | 1976 |
On the hypnogenic and anticonvulsant activities of demethyldiazepam and chlordemethyldiazepam: time-effect relations.
Topics: Animals; Anticonvulsants; Chlorprothixene; Diazepam; Female; Hexobarbital; Hypnotics and Sedatives; Mice; Nordazepam; Pentylenetetrazole; Time Factors | 1977 |
Benzodiazepines and phenobarbital as antagonists of dissimilar chemical convulsants.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Picrotoxin; Therapeutic Equivalency | 1978 |
Lack of tolerance development to benzodiazepines in antagonism of the pentylenetetrazol discriminative stimulus.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Discrimination, Psychological; Drug Tolerance; Male; Pentylenetetrazole; Rats; Reinforcement Schedule | 1979 |
Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain.
Topics: Animals; Atropine; Brain; Brain Chemistry; Convulsants; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Harmaline; Male; Mice; Oxotremorine; Pentobarbital; Pentylenetetrazole; Picrotoxin; Tremor | 1976 |
Distribution and regulation of cyclic nucleotide levels in cerebellum, in vivo.
Topics: Amphetamine; Animals; Atropine; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Female; Harmaline; In Vitro Techniques; Mice; Oxotremorine; Pentylenetetrazole; Reserpine; Seizures; Stress, Physiological | 1977 |
Effect of benzodiazepines on central serotonergic neuron systems.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Cyproheptadine; Diazepam; Drug Interactions; In Vitro Techniques; Male; Mescaline; Mice; Muscle Contraction; Neurons; Pentylenetetrazole; Postural Balance; Rats; Serotonin; Synaptic Transmission; Synaptosomes; Time Factors | 1977 |
Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebellum; Cerebral Cortex; Clonazepam; Culture Techniques; Cyclic AMP; Diazepam; Male; Mice; Norepinephrine; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Potassium; Premedication; Seizures | 1979 |
[Experimental characteristics of the spectrum of pharmacologic activity of the tranquilizer lorazepam].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Chlordiazepoxide; Conflict, Psychological; Diazepam; Drug Synergism; Hexobarbital; Humans; Hypnotics and Sedatives; Inhibition, Psychological; Mice; Muscle Relaxants, Central; Nicotine; Nitrazepam; Pentylenetetrazole; Rats; Reaction Time | 1975 |
Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoniazid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Strychnine | 1975 |
Further studies on the site of action of diazepam: anticonvulsant effect in the rabbit.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Electroencephalography; Female; Hippocampus; Male; Pentylenetetrazole; Phenobarbital; Rabbits; Seizures | 1979 |
Purinergic inhibition of diazepam binding to rat brain (in vitro).
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Kinetics; Pentylenetetrazole; Purines; Pyrimidines; Rats; Receptors, Drug; Xanthines | 1979 |
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Picrotoxin; Prostaglandins; Seizures; Thromboxanes; Time Factors; Trimethadione | 1979 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; Flurazepam; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Seizures; Trimethadione | 1977 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Male; Mice; Pentylenetetrazole; Seizures; Strychnine | 1977 |
Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro.
Topics: Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Imipramine; In Vitro Techniques; Male; Mice; Penicillin G; Pentylenetetrazole; Picrotoxin; Receptors, Drug; Synaptosomes | 1978 |
Rapid changes in brain benzodiazepine receptors after experimental seizures.
Topics: Animals; Binding Sites; Brain; Cerebral Cortex; Diazepam; Electroshock; Hypoxia; Kinetics; Male; Pentylenetetrazole; Rats; Receptors, Drug; Seizures; Synaptosomes | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitro Techniques; Neurons; Pentylenetetrazole; Phenytoin; Trimethadione | 1978 |
Changes in the convulsion threshold and in the level of brain biogenic amines in rats chronically treated with phenobarbital or diazepam.
Topics: Animals; Biogenic Amines; Brain Chemistry; Diazepam; Dopamine; Drug Synergism; Male; Norepinephrine; Pentylenetetrazole; Phenobarbital; Rats; Seizures; Serotonin | 1978 |
Effects of acute cerebellectomy on maximal electroshock seizures and anticonvulsant efficacy of diazepam in the rat.
Topics: Animals; Cerebellum; Diazepam; Electroshock; Male; Pentylenetetrazole; Rats; Seizures | 1976 |
Diazepam suppression of evoked after-discharges in rat lateral geniculate nucleus and visual cortex.
Topics: Animals; Diazepam; Drug Interactions; Evoked Potentials; Geniculate Bodies; Pentylenetetrazole; Photic Stimulation; Rats; Visual Cortex | 1976 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; Electroshock; Ethanol; Female; Flunitrazepam; Male; Muscimol; Orchiectomy; Ovariectomy; Pentylenetetrazole; Pregnanediones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sex Characteristics | 1992 |
Involvement of central GABAA receptor complex in controlling the basal gastric secretory activity in pylorus-ligated rats.
Topics: Analysis of Variance; Anesthesia; Animals; Bicuculline; Diazepam; Gastric Acid; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; Male; Midazolam; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
The comparative effects of propofol, thiopental, and diazepam, administered intravenously, on pentylenetetrazol seizure threshold in the rabbit.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Injections, Intravenous; Male; Pentylenetetrazole; Propofol; Rabbits; Seizures; Thiopental | 1992 |
Behavioural effects of anxiogenic agents in the common marmoset.
Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Caffeine; Callithrix; Carbolines; Diazepam; Motor Activity; Pentylenetetrazole; Yohimbine | 1992 |
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Triazoles | 1992 |
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Probenecid; Seizures | 1992 |
Interactions between angiotensin II, diazepam, clonazepam and di-n-propylacetate in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Clonazepam; Diazepam; Drug Interactions; Electric Stimulation; Ionophores; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Valproic Acid | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed | 1991 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A Receptor Antagonists; Isoniazid; Male; Mice; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Seizures | 1991 |
Pharmacological effects on two inbred substrains of AB mice.
Topics: Aggression; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Haloperidol; Hexobarbital; Mice; Mice, Inbred Strains; Neurotransmitter Agents; Pentylenetetrazole; Species Specificity | 1991 |
Anxiolytic activity of Panax ginseng roots: an experimental study.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Diazepam; Exploratory Behavior; Isatin; Male; Mice; Monoamine Oxidase Inhibitors; Panax; Pentylenetetrazole; Plants, Medicinal; Rats; Rats, Inbred Strains | 1991 |
Effects of DN-2327, a new anxiolytic, diazepam and buspirone on exploratory activity of the rat in an elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Exploratory Behavior; Flumazenil; Isoindoles; Male; Naphthyridines; Pentylenetetrazole; Rats; Rats, Inbred Strains; Spiro Compounds; Yohimbine | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Piperazines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1990 |
Convulsants induce interleukin-1 beta messenger RNA in rat brain.
Topics: Animals; Brain; Convulsants; Dexamethasone; Diazepam; DNA; Gene Expression; Interleukin-1; Kainic Acid; Kinetics; Male; Nucleic Acid Hybridization; Organ Specificity; Pentylenetetrazole; Rats; Rats, Inbred Strains; RNA; RNA, Messenger | 1990 |
Effects of age and drugs on food and fluid intake.
Topics: Aging; Amphetamines; Animals; Behavior, Animal; Benzodiazepines; Body Weight; Diazepam; Drinking; Drug Combinations; Eating; Female; Models, Biological; Pentylenetetrazole; Piracetam; Rats; Rats, Inbred Strains; Time Factors | 1991 |
The effect of ofloxacin and ciprofloxacin on pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Ciprofloxacin; Diazepam; Epilepsy, Tonic-Clonic; Male; Mice; Ofloxacin; Pentylenetetrazole | 1991 |
Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain.
Topics: Animals; Brain; Diazepam; Isatin; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pentylenetetrazole; Phenylalanine; Rats; Rats, Inbred Strains; Tryptophan; Tyrosine; Yohimbine | 1991 |
Paroxysmal activity in the rabbit visual cortex induced by photostimulation.
Topics: Animals; Caffeine; Diazepam; Electroencephalography; Epilepsy; Pentylenetetrazole; Photic Stimulation; Rabbits; Visual Cortex | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Tiagabine | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Aminobutyric Acid; Mesocricetus; Mutation; Pentylenetetrazole; Phenobarbital; Phenytoin; Synaptic Transmission; Valproic Acid | 1991 |
Brahmighritham, an Ayurvedic herbal formula for the control of epilepsy.
Topics: Administration, Oral; Animals; Diazepam; Electroencephalography; Epilepsy; Injections, Intraperitoneal; Male; Medicine, Ayurvedic; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Aversive and compensatory classical conditioning with diazepam as conditional stimulus.
Topics: Animals; Arousal; Association Learning; Avoidance Learning; Conditioning, Classical; Diazepam; Electroshock; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1991 |
Intravenous midazolam suppression of pentylenetetrazol-induced epileptogenic activity in a porcine model.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Diazepam; Electroencephalography; Epilepsies, Partial; Midazolam; Pentylenetetrazole; Swine | 1990 |
Diazepam sensitive mice: differential sensitivity to the depressant and anticonvulsant effects of diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Mice; Mice, Inbred Strains; Motor Activity; Muscle Relaxation; Pentylenetetrazole; Reflex; Seizures; Species Specificity; Time Factors | 1990 |
Effect of diazepam and medazepam on pentylenetetrazol kindling in albino rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Kindling, Neurologic; Male; Medazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1990 |
The long-term effects of diazepam and pentylenetetrazol on the potentiated startle response.
Topics: Acoustic Stimulation; Animals; Anxiety; Conditioning, Classical; Diazepam; Electroshock; Male; Pentylenetetrazole; Rats; Reflex, Startle; Stress, Psychological; Time Factors | 1990 |
Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex.
Topics: Animals; Benzodiazepinones; Chlorides; Diazepam; Flumazenil; Ion Channels; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sex Factors; Temperature; Vocalization, Animal | 1986 |
Decreased sensitivity to benzodiazepine receptor agonists and increased sensitivity to inverse agonists following chronic treatments: evidence for separate mechanisms.
Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Benzodiazepines; Carbolines; Chlorides; Diazepam; Drug Interactions; Drug Tolerance; Exploratory Behavior; Ion Channels; Kindling, Neurologic; Locomotion; Lorazepam; Mice; Muscimol; Pentylenetetrazole; Rats; Receptors, GABA-A | 1988 |
Sensitivity of pentylenetetrazol discrimination increased by a stimulus fading technique.
Topics: Animals; Benzodiazepinones; Diazepam; Discrimination, Psychological; Male; Nicotine; Pentylenetetrazole; Rats | 1989 |
Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: continuous shift from inverse agonist to agonist properties depending on the size of the alkyl substituent.
Topics: Animals; Chemical Phenomena; Chemistry; Diazepam; Drug Synergism; Male; Mice; Molecular Structure; Pentylenetetrazole; Pyrazoles; Quinolines; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Thiophenes | 1989 |
Diazepam reverses the effects of pentylenetetrazole in rat pups by acting at type 2 benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Female; Male; Pentylenetetrazole; Rats; Receptors, GABA-A; Tremor | 1989 |
Anticonvulsant and other effects of diazepam grow with time after a single treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Antipsychotic Agents; Blepharoptosis; Brain Chemistry; Catalepsy; Diazepam; Dopamine; Drug Interactions; Flumazenil; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Stress, Psychological; Time Factors | 1989 |
Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Drug Tolerance; Imidazoles; Injections, Intraperitoneal; Male; Mice; Pentylenetetrazole; Pyrimidines; Seizures | 1989 |
The effect of agonists at the GABA-benzodiazepine-receptor-complex on the proconflict effect induced by beta-CCM and pentetrazol in rats.
Topics: Aminooxyacetic Acid; Animals; Azabicyclo Compounds; Carbolines; Conflict, Psychological; Convulsants; Diazepam; Flumazenil; Hypnotics and Sedatives; Male; Pentylenetetrazole; Phenobarbital; Piperazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.
Topics: Animals; Biological Transport; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Lysine; Male; Mice; Pentylenetetrazole; Pipecolic Acids; Receptors, GABA-A; Seizures | 1988 |
[Effector modeling of the effect of ligands of GABA receptor complex. Modification of conformation states of the complex by combined administration of benzodiazepines and barbiturates].
Topics: Animals; Anti-Anxiety Agents; Barbital; Barbiturates; Benzodiazepines; Benzodiazepinones; Bicuculline; Diazepam; Drug Antagonism; Female; Ligands; Mice; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
Demonstration of the partial agonist profiles of Ro 16-6028 and Ro 17-1812 in mice in vivo.
Topics: Animals; Anticonvulsants; Ataxia; Benzodiazepinones; Brain; Conflict, Psychological; Diazepam; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Receptors, GABA-A | 1988 |
Tolerance to the anticonvulsant action of benzodiazepines. Relationship to decreased receptor density.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Diazepam; Drug Tolerance; Flunitrazepam; Male; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; Electroshock; Male; Mice; Nordazepam; Pentylenetetrazole; Seizures | 1985 |
Does the excitatory amino acid receptor antagonist 2-APH exhibit anxiolytic activity?
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Discrimination, Psychological; Drug Interactions; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1986 |
Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Feeding Behavior; Flumazenil; Male; Mice; Motor Activity; Pentylenetetrazole; Rats; Seizures | 1988 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Therapy, Combination; Male; Niacinamide; Pentylenetetrazole; Pyridoxal Phosphate; Rats; Seizures; Valproic Acid; Vitamin E; Vitamins | 1985 |
Enhancement of diazepam activities induced by denzimol in mice.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Imidazoles; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenobarbital; Receptors, GABA-A; Time Factors | 1985 |
CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents.
Topics: Acoustic Stimulation; Aggression; Agonistic Behavior; Animals; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Motor Activity; Muscle Contraction; Muscle Relaxation; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
The effects of beta-carboline carboxylic acid ethyl ester and its free acid, administered ICV, on the anticonvulsant activity of diazepam and sodium valproate in the mouse.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Drug Interactions; Female; Mice; Mice, Inbred C3H; Pentylenetetrazole; Receptors, GABA-A; Seizures; Valproic Acid | 1986 |
Cerebellar cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Bucladesine; Cerebellum; Diazepam; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Male; Nucleotides, Cyclic; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.
Topics: Amino Alcohols; Animals; Anticonvulsants; Ataxia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Diazepam; Electroshock; Esters; Muscimol; Pentylenetetrazole; Phenytoin; Piperidines; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1986 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Apparent pA2 estimation of benzodiazepine receptor antagonists.
Topics: Animals; Diazepam; Drug Interactions; Female; Flumazenil; Male; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
Mapping patterns of c-fos expression in the central nervous system after seizure.
Topics: Animals; Brain Chemistry; Diazepam; DNA-Binding Proteins; Fluorescent Antibody Technique; Gene Expression Regulation; Mice; Mice, Inbred BALB C; Neurons; Pentobarbital; Pentylenetetrazole; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Receptors, GABA-A; Seizures | 1987 |
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbillinae; Kindling, Neurologic; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phenobarbital; Piperazines; Psychomotor Performance; Rats; Time Factors | 1988 |
Benzodiazepine cross-tolerance in mice extends to sodium valproate.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Clonazepam; Diazepam; Drug Tolerance; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Valproic Acid | 1986 |
CGS 8216: agonist and diazepam-antagonist effects in rodents.
Topics: Animals; Ataxia; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mice; Pentylenetetrazole; Pyrazoles; Rats; Rats, Inbred F344; Reinforcement, Psychology | 1986 |
Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentylenetetrazol (PTZ).
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1986 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures | 1987 |
Imipramine treatment alters the pharmacokinetics and pharmacodynamics of diazepam.
Topics: Animals; Blood Proteins; Brain Chemistry; Diazepam; Drug Interactions; Imipramine; Liver; Male; Nordazepam; Oxazepam; Pentylenetetrazole; Protein Binding; Rats; Rats, Inbred Strains; Temazepam | 1987 |
Quantal detection and homogeneous sensitivity in a pentylenetetrazol discrimination.
Topics: Animals; Conditioning, Operant; Diazepam; Discrimination, Psychological; Male; Pentylenetetrazole; Rats; Reinforcement Schedule | 1988 |
Time dependent pentylenetetrazol-like cues subsequent to diazepam administration.
Topics: Animals; Conditioning, Operant; Cues; Diazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
A behavioral and electrocorticographic comparison of diazepam and pentylenetetrazol in rat pups.
Topics: Animals; Animals, Newborn; Diazepam; Electrodes, Implanted; Electrophysiology; Pentylenetetrazole; Rats; Rats, Inbred Strains; Tremor | 1988 |
Ethanol and Ro 15-4513: behaviour maintained by operant procedures (DRL-72s and PTZ-drug discrimination) in rats.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Generalization, Stimulus; Male; Mental Recall; Pentylenetetrazole; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1988 |
One stressful event blocks multiple actions of diazepam for up to at least a month.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebral Cortex; Diazepam; Dopamine; Male; Pain; Pentylenetetrazole; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological | 1988 |
Possible involvement of the central GABAergic system in pentobarbital-stimulated gastric acid secretion in the perfused rat stomach preparation.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Male; Pentobarbital; Pentylenetetrazole; Perfusion; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diazepam; Electroencephalography; Hippocampus; Injections; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
The anticonvulsive activity and toxicity of diazepam in three different formulations. An experimental study in mice.
Topics: Animals; Diazepam; Emulsions; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Seizures | 1987 |
[Effects of sklareol-glycol on pentylenetetrazole-induced convulsions and its interaction with diazepam].
Topics: Animals; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Pentylenetetrazole; Reaction Time; Seizures | 1987 |
The long-term effects of diazepam and pentylenetetrazol on behavioral sensitivity to a stressor.
Topics: Animals; Conditioning, Classical; Conditioning, Operant; Diazepam; Fear; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1987 |
Modification of amygdala-kindled postictal inhibition by pentylenetetrazol and diazepam.
Topics: Amygdala; Animals; Diazepam; Kindling, Neurologic; Male; Membrane Potentials; Neural Inhibition; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1987 |
Effect of a cholecystokinin antagonist on some effects of diazepam.
Topics: Animals; Cholecystokinin; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Proglumide; Seizures | 1987 |
Anxiety-like subjective effect of ethanol antagonist RO 15-4513 demonstrated in pentylenetetrazol discrimination.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Diazepam; Discrimination, Psychological; Male; Pentylenetetrazole; Rats | 1987 |
Tolerance to anti-pentylenetetrazol effects following chronic diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1986 |
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Diazepam; Electroshock; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Male; Neural Inhibition; Pentobarbital; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1986 |
Therapeutic safety studies of brotizolam in animals.
Topics: Aggression; Animals; Azepines; Diazepam; Hypnotics and Sedatives; Mice; Pentylenetetrazole; Psychomotor Performance | 1986 |
Differentiation of alcohol and barbital physical dependence.
Topics: Animals; Barbital; Barbiturates; Diazepam; Ethanol; Ethosuximide; Male; Mice; Morphine; Naloxone; Pentylenetetrazole; Phenytoin; Substance Withdrawal Syndrome | 1986 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; Nitrendipine; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Substance Withdrawal Syndrome; Verapamil | 1986 |
Intraosseous diazepam suppression of pentylenetetrazol-induced epileptogenic activity in pigs.
Topics: Animals; Blood Pressure; Diazepam; Heart Rate; Injections, Intravenous; Pentylenetetrazole; Seizures; Swine; Tibia | 1987 |
An EEG investigation on the role of cerebello-rubral system in the effects of diazepam and pentobarbital.
Topics: Animals; Benzodiazepinones; Cerebellum; Diazepam; Electroencephalography; Female; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rabbits; Red Nucleus | 1985 |
[The hippocampus as the determinant structure generating epileptic activity during korazol kindling].
Topics: Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Dimethyl Sulfoxide; Electroencephalography; Epilepsies, Myoclonic; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Seizures | 1985 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; Pentylenetetrazole; Seizures; Species Specificity; Time Factors | 1985 |
Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse.
Topics: Animals; Convulsants; Diazepam; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures | 1985 |
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Haloperidol; Lithium; Male; Mice; Pentylenetetrazole; Picrotoxin | 1985 |
The use of pharmacologic techniques in the confirmation of the isoelectric EEG.
Topics: Brain; Brain Death; Death; Diazepam; Electroencephalography; Humans; Pentylenetetrazole | 1970 |
Metabolism and anticonvulsant activity of deuterated N-demethyldiazepam.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dealkylation; Deuterium; Diazepam; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mice; Microsomes, Liver; NADP; Pentylenetetrazole; Structure-Activity Relationship; Time Factors | 1973 |
Anticonvulsant testing with a new analeptic convulsant: N-sulfamoyl-hexahydro-azepine (Sah 41-178).
Topics: Acetamides; Animals; Anticonvulsants; Azepines; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Glutethimide; Haloperidol; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Strychnine; Sulfonamides; Trimethadione | 1973 |
Pharmacologic studies with triflubazam (ORF 8063): a new psychotherapeutic agent.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Appetite Depressants; Behavior, Animal; Cats; Chlordiazepoxide; Diazepam; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Eating; Electroshock; Ethanol; Female; Hemodynamics; Humans; Hydrocarbons, Fluorinated; Hypnotics and Sedatives; Lethal Dose 50; Male; Mice; Motor Skills; Neurologic Manifestations; Pentylenetetrazole; Seizures; Species Specificity; Time Factors | 1974 |
The synthesis and pharmacology of a novel benzodiazepine derivative, 1-methyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one(ID-540).
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Bemegride; Benzodiazepinones; Cats; Chlorprothixene; Diazepam; Drug Synergism; Electroencephalography; Electroshock; Female; Fluorobenzenes; Hexobarbital; Humans; Lethal Dose 50; Male; Mice; Motor Activity; Muscle Tonus; Olfactory Bulb; Pentylenetetrazole; Rats; Reflex; Seizures; Septum Pellucidum; Strychnine | 1974 |
Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class.
Topics: Aggression; Amphetamine; Animals; Anti-Anxiety Agents; Avoidance Learning; Carbamates; Chlordiazepoxide; Diazepam; Drug Synergism; Electroencephalography; Electroshock; Female; Humans; Male; Mice; Motor Activity; Muscle Tonus; Pentobarbital; Pentylenetetrazole; Rabbits; Rats; Seizures; Sleep; Strychnine | 1974 |
An animal model of light sensitive epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Diazepam; Electroencephalography; Electromyography; Electrophysiology; Evoked Potentials; Eye Movements; Female; Haplorhini; Light; Male; Noise; Pentylenetetrazole; Phenobarbital; Photosensitivity Disorders; Seizures; Sleep; Trimethadione | 1967 |
Modifications of cortical responsiveness in humans induced by drugs acting on the central nervous system.
Topics: Barbiturates; Cerebral Cortex; Diazepam; Evoked Potentials; Humans; Pentylenetetrazole | 1967 |
Effects of intravenous Valium on the EEG changes caused by intravenous injection of Cardiazol; proposals for perfecting "Cardiazol activation".
Topics: Cerebral Cortex; Diazepam; Electroencephalography; Evoked Potentials; Humans; Injections, Intravenous; Pentylenetetrazole; Stimulation, Chemical | 1967 |
Metrazol-valium combination for EEG activation.
Topics: Diazepam; Electroencephalography; Humans; Pentylenetetrazole; Seizures | 1970 |
Pyrazapon (CI-683): a new antianxiety agent.
Topics: Animals; Anticonvulsants; Anxiety; Azepines; Behavior, Animal; Blood Pressure; Chlordiazepoxide; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Electroencephalography; Feeding Behavior; Female; Haplorhini; Hemodynamics; Humans; Kidney; Ligation; Locomotion; Macaca; Male; Mice; Pentylenetetrazole; Postural Balance; Pyrazoles; Rats; Self Stimulation; Species Specificity; Tranquilizing Agents | 1974 |
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Cortisone; Cytochrome c Group; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Female; Guinea Pigs; Hexobarbital; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Oxidoreductases; Pentylenetetrazole; Pharmaceutical Preparations; Phenobarbital; Rats; Research; Sleep; Spironolactone | 1972 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Diphenhydramine; Electroencephalography; Ethers; Fluorine; Haplorhini; Hydroxides; Hydroxylamines; Isoflurophate; Pentylenetetrazole; Picrotoxin; Pyridoxine; Reserpine; Seizures; Semicarbazides; Strychnine | 1969 |
Jumping activity induced by sodium 5-(1,3-dimethylbutyl)-5-ethyl barbiturate. I. The role of the sympathetic nervous system.
Topics: Adrenergic beta-Antagonists; Amino Alcohols; Amobarbital; Animals; Anticonvulsants; Barbiturates; Benzazepines; Blood Glucose; Body Temperature; Brain Chemistry; Caffeine; Chlordiazepoxide; Chlorisondamine; Dextroamphetamine; Diazepam; Drug Synergism; Fatty Acids, Nonesterified; Male; Mice; Motor Activity; Pempidine; Pentobarbital; Pentylenetetrazole; Phentolamine; Propranolol; Sympathetic Nervous System | 1970 |
Effect of central stimulants and depressants on mouse brain acetylcholine and choline levels.
Topics: Acetylcholine; Amphetamine; Animals; Atropine; Brain Chemistry; Central Nervous System Stimulants; Chlorpromazine; Choline; Depression, Chemical; Desipramine; Diazepam; Haloperidol; Ketones; Male; Mice; Pentobarbital; Pentylenetetrazole; Physostigmine; Reserpine; Stimulation, Chemical; Tranquilizing Agents; Tremorine | 1972 |
Quinazolines and 1,4-benzodiazepines. 69. 1-Vinyl-1,4-benzodiazepin-2-ones and 1-vinylquinazolin-2(1H)-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Chlordiazepoxide; Depression, Chemical; Diazepam; Flurazepam; Lethal Dose 50; Mice; Pentylenetetrazole; Quinazolines; Seizures; Vinyl Compounds | 1974 |
Effect on pseudoconditioning of drugs with known central nervous activity.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione | 1974 |
Comparative evaluation of the central nervous system activity of diazepam and its metabolites (demethyl-diazepam, methyl-oxazepam and oxazepam).
Topics: Animals; Central Nervous System; Dealkylation; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; Hexobarbital; Hydroxylation; Mice; Motor Activity; Muscle Relaxants, Central; Muscles; Oxazepam; Pentylenetetrazole; Sleep; Strychnine; Time Factors | 1974 |
The pharmacology of fletazepam a centrally-acting muscle relaxant.
Topics: Aggression; Animals; Anticonvulsants; Avoidance Learning; Benzazepines; Benzodiazepines; Cats; Diazepam; Dose-Response Relationship, Drug; Electroshock; Female; Fluorobenzenes; Humans; Male; Mice; Muscle Relaxants, Central; Muscle Rigidity; Pentylenetetrazole; Rats; Reflex; Seizures; Strychnine; Time Factors | 1974 |
Brain and serum concentrations of diazepam in experimental epilepsy.
Topics: Acute Disease; Animals; Brain; Cats; Diazepam; Dose-Response Relationship, Drug; Penicillin G; Pentylenetetrazole; Potassium; Seizures; Time Factors | 1974 |
Antagonism of pentylenetetrazol excitation by anticonvulsants on single brain stem neurons.
Topics: Animals; Anticonvulsants; Brain Stem; Cats; Decerebrate State; Diazepam; Drug Antagonism; In Vitro Techniques; Microelectrodes; Neurons; Pentobarbital; Pentylenetetrazole; Phenytoin; Stereotaxic Techniques; Time Factors; Trimethadione | 1972 |
Metrazol (Leptazol, Cardiazol) with ECT.
Topics: Diazepam; Electroconvulsive Therapy; Humans; Injections, Intravenous; Pentylenetetrazole; Positive-Pressure Respiration; Succinylcholine | 1973 |
Succinylcholine in EST.
Topics: Diazepam; Electroconvulsive Therapy; Humans; Injections, Intravenous; Mental Disorders; Methohexital; Pentylenetetrazole; Succinylcholine | 1973 |
Letters to the editor: Drug dosage in ECT.
Topics: Depression; Diazepam; Electroconvulsive Therapy; Humans; Injections, Intravenous; Methohexital; Pentylenetetrazole; Premedication; Succinylcholine | 1973 |
Diazepam metabolism and anticonvulsant activity in newborn animals.
Topics: Age Factors; Animals; Anticonvulsants; Appetite; Appetite Depressants; Brain; Chlorine; Chromatography, Gas; Dealkylation; Diazepam; Dopamine; Guinea Pigs; In Vitro Techniques; Male; Norepinephrine; Pentylenetetrazole; Rats; Serotonin | 1973 |
Effects of diazepam on dorsal root potentials induced by cortical paroxysmal activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Blood Pressure; Body Temperature; Cats; Cerebral Cortex; Decerebrate State; Diazepam; Electric Stimulation; Electroencephalography; Evoked Potentials; Laminectomy; Neural Inhibition; Pentylenetetrazole; Photic Stimulation; Seizures; Spinal Cord; Spinal Nerve Roots; Time Factors | 1973 |
Pentylenetetrazol convulsions and brain catecholamine turnover rate in rats and mice receiving diphenylhydantoin or benzodiazepines.
Topics: Animals; Benzazepines; Body Temperature; Brain; Brain Chemistry; Catecholamines; Cerebellum; Chlordiazepoxide; Corpus Striatum; Diazepam; Dopamine; Hypothalamus; Kinetics; Male; Methyltyrosines; Mice; Norepinephrine; Pentylenetetrazole; Phenytoin; Rats; Seizures | 1973 |
Effect of diazepam on mouse whole brain and brain area acetylcholine and choline levels.
Topics: Acetylcholine; Acetylcholinesterase; Acetyltransferases; Animals; Brain; Brain Chemistry; Cerebellum; Choline; Diazepam; Diencephalon; Electrophoresis, Paper; Female; Mesencephalon; Mice; Pentylenetetrazole; Time Factors | 1974 |
Synthesis and CNS activity of 3-substituted 7-chloro-5-phenyl-1,3,4-benzotriazepin-2-ones.
Topics: Alkylation; Animals; Anticonvulsants; Behavior, Animal; Benzazepines; Central Nervous System; Chlordiazepoxide; Cricetinae; Cyclization; Depression, Chemical; Diazepam; Drug Synergism; Electroshock; Exploratory Behavior; Hexobarbital; Hypnotics and Sedatives; Lethal Dose 50; Mass Spectrometry; Methamphetamine; Mice; Motor Activity; Muscle Tonus; Pentylenetetrazole; Reflex; Sleep | 1974 |
[On the raised convulsion threshold through diazepam in therapeutic pentamethylentetrazol induced convulsion].
Topics: Adult; Cerebral Cortex; Child; Convulsive Therapy; Diazepam; Electroencephalography; Epilepsy, Absence; Female; Humans; Male; Pentylenetetrazole; Psychotic Disorders | 1967 |
Diazepam as anticonvulsant in epileptic and normal monkeys.
Topics: Animals; Chlordiazepoxide; Diazepam; Electroencephalography; Haplorhini; Injections, Intramuscular; Injections, Intravenous; Pentylenetetrazole; Seizures | 1967 |
The pharmacology of prazepam. A new benzodiazepine derivative.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Chlordiazepoxide; Diazepam; Dogs; Electroshock; Escape Reaction; Female; Haplorhini; Humans; Male; Meprobamate; Mice; Motor Activity; Muscle Contraction; Muscle, Smooth; Pentylenetetrazole; Phenobarbital; Rats; Reflex; Seizures; Strychnine; Time Perception; Tranquilizing Agents | 1970 |
[Pharmacological studies of a new minor tranquilizer, dipotassium chlorazepate (7-chloro-1,3-dihydro-2-oxo-5-phenyl-1H-1, 4-benzodiazepine 3-carboxylic acid monopotassium salt monopotassium hydroxide). 1. Central action].
Topics: Animals; Anticonvulsants; Apomorphine; Bemegride; Benzazepines; Central Nervous System; Cerebral Cortex; Diazepam; Dogs; Electroencephalography; Evoked Potentials; Hexobarbital; Hypothalamus; Limbic System; Male; Mice; Morphine; Nicotine; Pentylenetetrazole; Rats; Strychnine; Tranquilizing Agents; Tremorine | 1972 |
Metabolism and anticonvulsant activity of diazepam in guinea pigs.
Topics: Adipose Tissue; Animals; Anticonvulsants; Brain; Chromatography, Gas; Diazepam; Drug Antagonism; Guinea Pigs; Kinetics; Male; Methylation; Oxazepam; Pentylenetetrazole; Seizures; Time Factors; Tremor | 1971 |
[Combined action of diazepam, alpha-methyldopa and reserpine on the effect of pentamethylenetetrazole in mice].
Topics: Animals; Diazepam; Drug Antagonism; Drug Synergism; Male; Methyldopa; Mice; Pentylenetetrazole; Reserpine; Seizures | 1969 |
Chemistry and CNS-pharmacological properties of two hydrosoluble benzodiazepine derivatives.
Topics: Animals; Avoidance Learning; Behavior, Animal; Central Nervous System; Chemical Phenomena; Chemistry, Physical; Depression, Chemical; Diazepam; Dibenzazepines; Drug Synergism; Hexobarbital; Locomotion; Male; Methamphetamine; Motor Activity; Oxazepam; Pentylenetetrazole; Rats; Stimulation, Chemical; Time Factors | 1969 |
[Animal experimental comparison of tranquilizing effect of doxepine with known psychopharmaceuticals].
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Conditioning, Classical; Depression, Chemical; Diazepam; Dibenzoxepins; Drug Synergism; Electroshock; Exploratory Behavior; Fear; Female; Humans; Hypnotics and Sedatives; Male; Mice; Movement; Muscle Relaxants, Central; Opipramol; Pentylenetetrazole; Rats; Strychnine; Thioridazine; Tranquilizing Agents; Urethane | 1969 |
Studies on the anticonvulsant action of diazepam.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, Gas; Diazepam; Mice; Oxazepam; Pentylenetetrazole; Rats; Seizures | 1970 |
Further studies on the long lasting antimetrazol activity of diazepam in mice.
Topics: Animals; Brain Chemistry; Diazepam; Male; Mice; Oxazepam; Pentylenetetrazole | 1970 |
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
Topics: Aggression; Animals; Chlordiazepoxide; Diazepam; Electroshock; Exploratory Behavior; Humans; Locomotion; Male; Meprobamate; Mice; Oxazepam; Pentobarbital; Pentylenetetrazole; Rats; Seizures; Tranquilizing Agents | 1970 |
Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice.
Topics: Adipose Tissue; Animals; Anticonvulsants; Benzazepines; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Diazepam; Female; Male; Mice; Muscles; Myocardium; Oxazepam; Pentylenetetrazole; Seizures; Time Factors; Tritium | 1970 |
[Anticonvulsant action of imipramine and imitriptyline associated with phenobarbital, phenytoin and diazepam].
Topics: Amitriptyline; Animals; Anticonvulsants; Diazepam; Electroshock; Imipramine; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures | 1970 |
Anticonvulsant and motor depressant effects of Diazepam.
Topics: Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Depression, Chemical; Diazepam; Dogs; Drug Antagonism; Electroencephalography; Electroshock; Mice; Motor Activity; Motor Cortex; Neuromuscular Junction; Pentylenetetrazole; Reticular Formation; Seizures; Spinal Nerves | 1970 |
[Comparison of the characteristics of the effect of tranquilizing agents under experimental and clinical conditions].
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Diseases; Chlordiazepoxide; Depression, Chemical; Diazepam; Drug Synergism; Electroshock; Emotions; Hexobarbital; Humans; Hypnotics and Sedatives; Mental Disorders; Meprobamate; Mice; Morpholines; Movement; Muscle Relaxants, Central; Neurotic Disorders; Orientation; Oxazepam; Pentylenetetrazole; Rats; Schizophrenia; Strychnine; Tranquilizing Agents | 1971 |
[Contribution of daizepam (valium) to the completion of cardiazolic activation in clinical electroencephalography].
Topics: Diazepam; Drug Synergism; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole | 1967 |
Autonomic response to pentamethylenetetrazol following trimetadione and benzodiazepines administration.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Glucose; Blood Pressure; Chlordiazepoxide; Curare; Diazepam; Drug Antagonism; Female; Hyperglycemia; Male; Oxazoles; Pentylenetetrazole; Pupil; Rabbits; Trimethadione | 1968 |
Effect of diazepam (Valium) on experimental seizures in unanesthetized cat.
Topics: Animals; Cats; Cerebral Cortex; Coma; Diazepam; Electroencephalography; Light; Pentylenetetrazole; Phenobarbital; Seizures | 1968 |
The effect of certain benzodaizepines on the threshold for pentylenetetrazol-induced seizures in the cat.
Topics: Animals; Benzazepines; Cats; Chlordiazepoxide; Diazepam; Pentylenetetrazole; Seizures; Time Factors | 1968 |
Diazepam as an aid in the photo-Metrazol activation test.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Diazepam; Electroencephalography; Female; Humans; Light; Male; Myoclonus; Pentylenetetrazole; Sleep; Wakefulness | 1968 |
Species difference in diazepam metabolism and anticonvulsant effect.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Injections, Intraperitoneal; Injections, Intravenous; Mice; Oxazepam; Pentylenetetrazole; Rats; Species Specificity | 1968 |
A metabolic explantation for differences between species of the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Injections, Intravenous; Mice; Pentylenetetrazole; Rats; Species Specificity | 1968 |
Certain aspects of pharmacological profiles of chlordiazepoxide and diazepam.
Topics: Analgesics; Animals; Benzazepines; Chlordiazepoxide; Diazepam; Drug Antagonism; Drug Synergism; Electroshock; Ethanol; Guinea Pigs; Mice; Morphine; Motor Activity; Neurons; Pentobarbital; Pentylenetetrazole; Rats; Seizures; Sleep; Strychnine | 1968 |
A new benzodiazepine: electroencephalographic studies of its anticonvulsant activity in non-anesthetized, non-curarized rabbits.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Diazepam; Dibenzazepines; Electrocardiography; Electroencephalography; Electroshock; Hypnotics and Sedatives; Hypothalamus; Oxazepam; Pentylenetetrazole; Rabbits; Reticular Formation; Strychnine; Thalamus | 1969 |
Some aspects of the action of valium and of librium on the electrical activity of the rabbit brain.
Topics: Animals; Anticonvulsants; Brain; Chlordiazepoxide; Diazepam; Electroconvulsive Therapy; Electroencephalography; Hypothalamus; Limbic System; Pentylenetetrazole; Rats; Reticular Formation; Seizures | 1965 |
Anticonvulsant properties of some benzodiazepines.
Topics: Animals; Anticonvulsants; Azepines; Cats; Chlordiazepoxide; Diazepam; Electric Stimulation; Electroconvulsive Therapy; Male; Mice; Neural Conduction; Pentylenetetrazole; Trimethadione | 1966 |
[Evoked potential and the cycle of cortical recovery in man used as tests for study of the action of neuropharmacological agents].
Topics: Brain; Diazepam; Electroencephalography; Humans; Pentylenetetrazole; Thiopental | 1966 |
Synthesis of some dibenzo[b,f][1,5]diazocines and dibenzo[b,f][1,4]diazocines.
Topics: Animals; Azocines; Chemistry, Organic; Chlordiazepoxide; Diazepam; Drug Antagonism; Electric Stimulation; Electrophysiology; Locomotion; Male; Mice; Muscles; Organic Chemistry Phenomena; Pentylenetetrazole; Tetrabenazine; Tranquilizing Agents; Tremorine | 1967 |
[Progressive myoclonus epilepsy with Lafora bodies. Clinical and polygraphic study. Anatomical ultrastructural verification].
Topics: Adolescent; Brain; Cytoplasmic Granules; Diazepam; Electrocardiography; Electroencephalography; Electromyography; Epilepsy; Female; Humans; Light; Myoclonus; Pentylenetetrazole | 1967 |
[Effects of intravenous Valium on the modifications of the EEG induced by the intravenous injection of Cardiazol. Proposals for an improvement of the "Cardiazolic activation"].
Topics: Adolescent; Adult; Brain; Diazepam; Electroencephalography; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Middle Aged; Pentylenetetrazole | 1967 |
Discriminative stimulus properties of beta-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors.
Topics: Animals; Carbolines; Chlordiazepoxide; Cues; Diazepam; Discrimination Learning; Discrimination, Psychological; Generalization, Stimulus; Indoles; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
In vivo determination of efficacy of pyrazoloquinolinones at the benzodiazepine receptor.
Topics: Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Flunitrazepam; Male; Mice; Pentylenetetrazole; Pyrazoles; Receptors, GABA-A | 1984 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Tolerance; Isoquinolines; Ligands; Male; Mice; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Strychnine | 1984 |
Brain cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Brain; Bucladesine; Cyclic AMP; Cyclic GMP; Diazepam; Dibutyryl Cyclic GMP; Electroencephalography; Electromyography; Female; Mice; Mice, Inbred ICR; Nucleotides, Cyclic; Pentylenetetrazole; Seizures | 1984 |
Modification of pyrazoloquinolinone affinity by GABA predicts efficacy at the benzodiazepine receptor.
Topics: Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Mice, Inbred Strains; Pentylenetetrazole; Pyrazoles; Radioligand Assay; Receptors, GABA-A; Seizures | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
Evidence that GABA mechanisms mediate the anxiolytic action of benzodiazepines: a study with valproic acid.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Discrimination Learning; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Valproic Acid | 1980 |
The proconvulsant and diazepam-reversing effects of ethyl-beta-carboline-3-carboxylate.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Cerebral Cortex; Convulsants; Diazepam; In Vitro Techniques; Indoles; Pentylenetetrazole; Rats; Receptors, Drug; Receptors, GABA-A | 1980 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Therapy, Combination; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Semicarbazides; Valproic Acid | 1981 |
Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Brain Chemistry; Conflict, Psychological; Diazepam; Female; Kinetics; Motor Activity; Nordazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1981 |
Quinazolines and 1,4-benzodiazepines. 90. Structure-activity relationship between substituted 2-amino-N-(2-benzoyl-4-chlorophenyl)acetamides and 1,4-benzodiazepinones.
Topics: Acetamides; Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Chemical Phenomena; Chemistry; Diazepam; Mice; Pentylenetetrazole; Structure-Activity Relationship | 1982 |
Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Carbolines; Chemical Phenomena; Chemistry; Diazepam; Drug Interactions; Indoles; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
2-Benzazepines. 2. Thiazolo[5,4-d][2]benzazepines.
Topics: Animals; Anti-Anxiety Agents; Benzazepines; Binding, Competitive; Chemical Phenomena; Chemistry; Diazepam; Male; Mice; Pentylenetetrazole | 1983 |
RO 15-1788 selectively reverses antagonism of pentylenetetrazol-induced discriminative stimuli by benzodiazepines but not by barbiturates.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Benzodiazepinones; Diazepam; Flumazenil; Male; Pentobarbital; Pentylenetetrazole; Rats; Stimulation, Chemical | 1982 |
[Effects of pentylenetetrazol on conflict behavior and interactions with anxiolytics in rats].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains | 1983 |
Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Psychological; Diazepam; Drinking Behavior; Drug Tolerance; Humans; Male; Mice; Motor Activity; Oxazepam; Pentylenetetrazole; Rats; Seizures; Substance Withdrawal Syndrome; Triazolam | 1984 |
Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Ceruletide; Cholecystokinin; Diazepam; Kinetics; Male; Mice; Pentylenetetrazole; Seizures; Sincalide; Strychnine; Time Factors | 1980 |
beta-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Diazepam; Drug Synergism; Indoles; Membranes; Pentylenetetrazole; Rats; Receptors, Drug; Receptors, GABA-A; Seizures | 1980 |
Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Binding, Competitive; Diazepam; Hypoxanthines; Inosine; Kynurenine; Ligands; Male; Mice; Mice, Inbred Strains; Niacinamide; Pentylenetetrazole; Receptors, Drug; Receptors, GABA-A; Seizures | 1981 |
Modification of diazepam's antileptazol activity by endogenous tryptophan-like compounds.
Topics: Adrenocorticotropic Hormone; Animals; Carbolines; Diazepam; Dipeptides; Female; Ligands; Mice; Pentylenetetrazole; Receptors, Drug; Receptors, GABA-A; Tryptophan | 1981 |
Role of benzodiazepine receptors in seizures.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Diazepam; Hypoxanthines; Inosine; Mice; Pentylenetetrazole; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
DMCM: a potent convulsive benzodiazepine receptor ligand.
Topics: Animals; Carbolines; Convulsants; Diazepam; Drug Interactions; Female; Indoles; Lorazepam; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Valproic Acid | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Tolerance to the anti-pentylenetetrazole effects of diazepam in the mouse.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Pentylenetetrazole; Picrotoxin; Time Factors | 1983 |
Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Seizures | 1983 |
Metabolic and pharmacological studies with N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloro-glycinanilide (F 1797).
Topics: Anilides; Animals; Anticonvulsants; Brain Chemistry; Diazepam; Male; Nordazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1983 |
Anxiogenic aspects of diazepam withdrawal can be detected in animals.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Discrimination Learning; Flumazenil; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1983 |
Anticonvulsant and antipunishment effects of toluene.
Topics: Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mice; Pentylenetetrazole; Punishment; Rats; Seizures; Time Factors; Toluene; Xylenes | 1984 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimination Learning; Flumazenil; Generalization, Stimulus; Humans; Male; Pentobarbital; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Characterization of convulsions induced by methyl beta-carboline-3-carboxylate in mice.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Flumazenil; Hypnotics and Sedatives; Indoles; Male; Mice; Pentylenetetrazole; Postural Balance; Time Factors | 1984 |
Development of tolerance to the anticonvulsant effect of diazepam in dogs.
Topics: Animals; Anticonvulsants; Diazepam; Dogs; Drug Tolerance; Electrocardiography; Electroencephalography; Female; Male; Nordazepam; Pentylenetetrazole; Seizures; Time Factors | 1984 |
[Interaction of kynurenine and diazepam].
Topics: Animals; Benzoates; Caffeine; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenine; Mice; Mice, Inbred Strains; Pentylenetetrazole; Reaction Time; Seizures | 1984 |
Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: progressive decline and effects of anticonvulsants.
Topics: Animals; Calcium-Binding Proteins; Diazepam; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative.
Topics: Aggression; Anesthesia; Animals; Anticonvulsants; Azepines; Behavior, Animal; Conflict, Psychological; Diazepam; Electroshock; Estazolam; Humans; Hypnotics and Sedatives; Male; Mice; Motor Activity; Nitrazepam; Olfactory Bulb; Pentylenetetrazole; Postural Balance; Raphe Nuclei; Rats; Rats, Inbred Strains; Thiopental | 1984 |
Effects of psychotropic drugs on the rage responses induced by electrical stimulation of the medial hypothalamus in cats.
Topics: Anger; Animals; Cats; Diazepam; Electric Stimulation; Female; Hypothalamus, Middle; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Psychotropic Drugs; Rage | 1983 |
Anticonvulsant action of diazepam in mice pretreated with caffeine.
Topics: Animals; Anticonvulsants; Behavior, Animal; Caffeine; Diazepam; Drug Interactions; Electroencephalography; Electromyography; Female; Mice; Mice, Inbred ICR; Pentylenetetrazole | 1983 |
Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam.
Topics: Animals; Diazepam; Drug Tolerance; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Myoclonus; Pentylenetetrazole; Seizures; Species Specificity | 1983 |
Behavioral comparison of pentylenetetrazol, clonidine, chlordiazepoxide and diazepam in infant rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Chlordiazepoxide; Clonidine; Diazepam; Motor Activity; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1983 |
2-Benzazepines. 4. [1,2,3]Triazolo[4,5-d][2]benzazepines and dibenzo[c,f][1,2,3]triazolo[3,4-a]azepines: synthesis and evaluation as central nervous system agents.
Topics: Animals; Behavior, Animal; Chemical Phenomena; Chemistry; Diazepam; Dibenzazepines; Pentylenetetrazole; Postural Balance; Triazoles | 1983 |
Inhibition of pentylenetetrazol induced genetically-determined stereotypic convulsions in tottering mutant mice by diazepam.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Pentylenetetrazole; Phenytoin; Seizures; Stereotyped Behavior | 1983 |
The pentylenetetrazol model of anxiety detects withdrawal from diazepam in rats.
Topics: Animals; Anxiety; Diazepam; Discrimination Learning; Disease Models, Animal; Humans; Male; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1983 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrrolidines; Seizures; Succinimides; Trimethadione; Valproic Acid | 1981 |
Anticonvulsant potency of unmetabolized diazepam.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Male; Mice; Nordazepam; Oxazepam; Pentylenetetrazole; Time Factors | 1982 |
The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats.
Topics: Amygdala; Animals; Diazepam; Doxapram; Kindling, Neurologic; Male; Pentylenetetrazole; Phenobarbital; Rats; Rats, Inbred Strains; Seizures | 1983 |
Discriminative stimulus properties of a small dose of cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dextroamphetamine; Diazepam; Dose-Response Relationship, Drug; Male; Methylphenidate; Pentylenetetrazole; Rats | 1983 |
Caffeine antagonizes several central effects of diazepam.
Topics: Aggression; Animals; Caffeine; Cats; Central Nervous System; Conflict, Psychological; Diazepam; Humans; Hypothalamus; Muscle Tonus; Pentylenetetrazole; Phenobarbital; Spinal Cord | 1981 |
Discriminative stimulus properties of cocaine related to an anxiogenic action.
Topics: Animals; Anxiety; Cocaine; Diazepam; Discrimination, Psychological; Haloperidol; Humans; Male; Pentylenetetrazole; Rats | 1981 |
The anticonvulsant properties of melatonin on kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Melatonin; Naloxone; Pentylenetetrazole; Phenobarbital; Rats; Seizures | 1981 |
In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Diazepam; Mice; Pentylenetetrazole | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Pentylenetetrazole; Phenobarbital; Rats; Seizures | 1981 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures | 1981 |
Effect of diazepam alone and in combination with chlorpromazine or propranolol in experimentally induced convulsions in mice.
Topics: Animals; Chlorpromazine; Diazepam; Drug Therapy, Combination; Electroshock; Male; Mice; Pentylenetetrazole; Propranolol; Seizures; Strychnine | 1981 |
[Pharmacological characterization of novel pyridazines. Part 1: Physicochemical parameters, acute toxicity and action on the central nervous system (author's transl)].
Topics: Animals; Central Nervous System; Chemical Phenomena; Chemistry, Physical; Diazepam; Drug Interactions; Hexobarbital; Lethal Dose 50; Mice; Motor Activity; Pentylenetetrazole; Pyridazines | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Male; Pentylenetetrazole; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Pentylenetetrazol-induced kindling in animals: protective effect of BR-16A.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Female; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Plant Extracts; Seizures | 1995 |
Discriminative stimulus properties of a new anxiolytic, DN-2327, in rats.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Generalization, Stimulus; Isoindoles; Male; Naphthyridines; Pentobarbital; Pentylenetetrazole; Rats; Rats, Wistar; Spiro Compounds | 1993 |
A behavioural and pharmacological evaluation of the discriminative stimulus induced by pentylenetetrazole in the pig.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cues; Diazepam; Discrimination, Psychological; Electroshock; Emotions; Ethosuximide; Male; Pentylenetetrazole; Reinforcement Schedule; Swine | 1993 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Excitatory Amino Acid Antagonists; Flumazenil; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Reflex; Seizures; Synaptic Transmission | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Imidazoles; Isoniazid; Male; Mice; Pentylenetetrazole; Pyridines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Solvents; Time Factors | 1993 |
Chronic pharmacological activities of the novel anxiolytic beta-carboline abecarnil in rats.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Drinking Behavior; Male; Memory; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 1994 |
Dehydroepiandrosterone is an anxiolytic in mice on the plus maze.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diazepam; Ethanol; Flumazenil; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pentylenetetrazole; Receptors, GABA | 1994 |
Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain; Diazepam; Drug Tolerance; Male; Midazolam; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 1994 |
[3H-diazepam binding in the rat brain 11 months after terminating korazol-induced kindling].
Topics: Animals; Cerebellum; Cerebral Cortex; Diazepam; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Receptors, GABA-A; Synaptic Membranes; Time Factors; Tritium | 1994 |
The influence of diazepam on learning processes impaired by pentylenetetrazol kindling.
Topics: Animals; Avoidance Learning; Diazepam; Injections, Intraperitoneal; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar | 1994 |
Anxiogenic-like effects induced by stimulation of dopamine receptors.
Topics: Animals; Anxiety; Benzazepines; Carbolines; Dextroamphetamine; Diazepam; Dopamine Agents; Dopamine Antagonists; Haloperidol; Male; Mice; Motor Activity; Pentylenetetrazole; Phenethylamines; Piperazines; Receptors, Dopamine; Receptors, Dopamine D1; Yohimbine | 1993 |
Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Arousal; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Handling, Psychological; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Strychnine | 1994 |
Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation.
Topics: Animals; Diazepam; Ethanol; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Seizures; Serotonin Antagonists; Stimulation, Chemical; Substance Withdrawal Syndrome | 1993 |
Characterisation of the central nervous depressant activity of a commercially available valerian root extract.
Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Chlorpromazine; Diazepam; Female; Mice; Motor Activity; Pentylenetetrazole; Plant Extracts; Plants, Medicinal; Sleep; Thiopental; Valerian | 1993 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diazepam; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Quinazolines; Rats; Rats, Wistar; Seizures | 1996 |
Protracted treatment with diazepam reduces benzodiazepine1 receptor-mediated potentiation of gamma-aminobutyric acid-induced currents in dissociated rat hippocampal neurons.
Topics: Allosteric Regulation; Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 1996 |
In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis.
Topics: Allylglycine; Animals; Binding, Competitive; Brain; Convulsants; Diazepam; Electroencephalography; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Tomography, Emission-Computed | 1997 |
Stimulatory effect of diazepam on gastric acid secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Anesthetics, Intravenous; Animals; Atropine; Diazepam; Flumazenil; GABA Agents; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gastric Acid; Gastric Mucosa; Hexamethonium; Isoquinolines; Male; Parasympatholytics; Pentylenetetrazole; Picrotoxin; Pylorus; Rats; Rats, Wistar; Receptors, GABA; Urethane; Vagotomy | 1997 |
A multiple-test study of anxiety-related behaviours in six inbred rat strains.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Diazepam; Factor Analysis, Statistical; Female; Lighting; Male; Pentylenetetrazole; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Rats, Wistar; Social Behavior; Species Specificity | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Subcutaneous; Kynurenic Acid; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1997 |
Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cell Count; Convulsants; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; Kindling, Neurologic; Learning; Male; Memory; Models, Neurological; Neurons; Pentylenetetrazole; Rats; Rats, Wistar | 1997 |
Anxiolytic-like effects of PNU-101017, a partial agonist at the benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Cells, Cultured; Cerebellum; Conflict, Psychological; Corticosterone; Cyclic GMP; Diazepam; Drinking Behavior; Electroshock; Ethanol; GABA-A Receptor Agonists; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Motor Activity; Muscle Relaxation; Pentylenetetrazole; Quinolines; Radioimmunoassay; Radioligand Assay; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Stress, Physiological | 1997 |
Functional characterization of a kindling-like model of ethanol withdrawal in cortical cultured neurons after chronic intermittent ethanol exposure.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Diazepam; Drug Administration Schedule; Ethanol; Female; GABA Modulators; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pentylenetetrazole; Substance Withdrawal Syndrome | 1997 |
NMDA-coupled periaqueductal gray glycine receptors modulate anxioselective drug effects on plus-maze performance.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Binding, Competitive; Central Nervous System Stimulants; Diazepam; Injections, Intraperitoneal; Kynurenic Acid; Male; Pentylenetetrazole; Periaqueductal Gray; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Sensitisation of withdrawal signs following repeated withdrawal from a benzodiazepine: differences between measures of anxiety and seizure sensitivity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Conflict, Psychological; Diazepam; Electroshock; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome | 1998 |
Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Convulsants; Diazepam; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission | 1998 |
Role of nitric oxide in the hypersusceptibility to pentylenetetrazole-induced seizure in diazepam-withdrawn mice.
Topics: Animals; Arginine; Diazepam; Enzyme Inhibitors; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome | 1998 |
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Drug Tolerance; Female; GABA-A Receptor Agonists; Imidazoles; Isoniazid; Ligands; Mice; Mice, Inbred Strains; Pentylenetetrazole; Rats; Rats, Inbred Strains; Saimiri; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
A neuropharmacological analysis of PTZ-induced kindling in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Diazepam; Glutamic Acid; Kindling, Neurologic; Male; Membranes; Mice; Pentylenetetrazole; Phenobarbital | 1998 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium Channels; Convulsants; Diazepam; Kindling, Neurologic; Male; Nifedipine; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Electroconvulsive Therapy; Epilepsy; Excitatory Amino Acid Agonists; Flumazenil; GABA-A Receptor Antagonists; Kindling, Neurologic; Levetiracetam; Male; Mice; Pentylenetetrazole; Piracetam; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Antagonism of kynurenic acid to anxiogens in mice.
Topics: Animals; Anxiety; Brain; Caffeine; Diazepam; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Kynurenic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Phenethylamines; Yohimbine | 1998 |
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Ethosuximide; Male; Mice; Nitroarginine; Pentylenetetrazole; Phenobarbital; Psychomotor Performance; Seizures; Valproic Acid | 1999 |
Role of metabotropic glutamate receptors in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Drug Interactions; Injections, Intraventricular; Ligands; Male; Mice; Pentylenetetrazole; Receptors, Metabotropic Glutamate; Seizures; Substance Withdrawal Syndrome | 1999 |
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protective Agents; Rats; Rats, Wistar; Seizures; Theophylline; Valproic Acid | 1997 |
Sex differences in the pentylenetetrazol-like stimulus induced by ethanol withdrawal.
Topics: Animals; Behavior, Animal; Castration; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Estradiol; Ethanol; Female; Male; Ovariectomy; Pentylenetetrazole; Rats; Rats, Long-Evans; Sex Factors; Stimulation, Chemical; Substance Withdrawal Syndrome | 1999 |
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Bridged Bicyclo Compounds; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2000 |
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Fear; Humans; Imidazoles; Male; Maze Learning; Nociceptin Receptor; Pain; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Recombinant Proteins; Reflex, Startle; Seizures; Self Stimulation; Spiro Compounds | 2000 |
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Seizures; Stereotypic Movement Disorder; Valproic Acid | 2000 |
Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system.
Topics: Animals; Anticonvulsants; Barbiturates; Brazil; Diazepam; Flumazenil; GABA Modulators; Hexanes; Hypnotics and Sedatives; Male; Mice; Muscle Relaxants, Central; Pentylenetetrazole; Plant Extracts; Plants, Medicinal; Receptors, GABA-A; Seizures | 2000 |
Pentylenetetrazol-kindling modulates stimulated dopamine release in the nucleus accumbens of rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dopamine; Kindling, Neurologic; Male; Nucleus Accumbens; Pentylenetetrazole; Rats; Rats, Wistar | 2000 |
The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid | 2000 |
Acute upregulation of blood-brain barrier glucose transporter activity in seizures.
Topics: 1-Butanol; Acute Disease; Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Carbon Radioisotopes; Carotid Arteries; Catheterization; Diazepam; Electroencephalography; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Injections, Intra-Arterial; Injections, Intravenous; Jugular Veins; Male; Monosaccharide Transport Proteins; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Tritium; Up-Regulation | 2000 |
Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cocaine; Convulsants; Diazepam; Dopamine Uptake Inhibitors; Drug Interactions; Hippocampus; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2000 |
Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Lippia; Mice; Oils, Volatile; Pentylenetetrazole; Plant Leaves; Seizures | 2000 |
Mechanism of action of the hypnotic zolpidem in vivo.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Female; GABA Antagonists; Hypnotics and Sedatives; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Motor Activity; Pentylenetetrazole; Pyridines; Receptors, GABA-A; Zolpidem | 2000 |
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epilepsy; GABA Antagonists; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Time | 2001 |
Use of negatively reinforcing electrical brain stimulation to detect conventional and nonconventional anxiolytics as well as an anxiogenic drug.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Buspirone; Carbolines; Convulsants; Diazepam; Electric Stimulation; Electrodes; Flumazenil; GABA Modulators; Male; Pentylenetetrazole; Rats; Rats, Long-Evans; Reinforcement, Psychology | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Aspirin; Diazepam; Male; Mice; Pentylenetetrazole; Prostaglandins; Seizures; Valproic Acid | 2001 |
GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Diazepam; Ethanol; Fever; Flumazenil; GABA Antagonists; Hypnotics and Sedatives; Male; Maze Learning; Mice; Mice, Knockout; Pentylenetetrazole; Phenobarbital; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Species Specificity; Stress, Physiological | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental | 2002 |
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Design; GABA-A Receptor Agonists; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Pentylenetetrazole; Postural Balance; Seizures; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Triazoles | 2003 |
22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state.
Topics: Animals; Anxiety; Behavior, Animal; Buspirone; Carbolines; Conditioning, Classical; Diagnosis, Differential; Diazepam; Disease Models, Animal; Fear; GABA Antagonists; GABA Modulators; Male; Mood Disorders; Pentylenetetrazole; Rats; Rats, Wistar; Reference Values; Serotonin Receptor Agonists; Ultrasonics; Vocalization, Animal | 2003 |
Evaluation of toluene dependence and cross-sensitization to diazepam.
Topics: Animals; Convulsants; Diazepam; Excitatory Amino Acid Agonists; Inhalation Exposure; Male; Mice; Motor Activity; N-Methylaspartate; Pentylenetetrazole; Seizures; Solvents; Substance-Related Disorders; Toluene | 2003 |
Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Flutamide; Infusions, Intravenous; Injections, Intraperitoneal; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Motor Skills; Pentylenetetrazole; Postural Balance; Premedication; Rats; Receptors, GABA-A; Seizures | 2003 |
Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice.
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety; Carbolines; Dextroamphetamine; Diazepam; Disease Models, Animal; Equipment and Supplies; Ethanol; Exploratory Behavior; Female; Male; Maze Learning; Mice; Mice, Inbred Strains; Motor Activity; Pentobarbital; Pentylenetetrazole; Polymorphism, Genetic | 2003 |
Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice.
Topics: Animals; Convulsants; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Oleic Acids; Pentylenetetrazole; Seizures; Sleep | 2003 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System Stimulants; Chlorisondamine; Chlorpromazine; Diazepam; Mephenesin; Meprobamate; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Picrotoxin; Research; Seizures; Strychnine; Tranquilizing Agents | 1963 |
ANTICONVULSANT PROPERTIES OF CHLORDIAZEPOXIDE, DIAZEPAM AND CERTAIN OTHER 1,4-BENZODIAZEPINES.
Topics: Animals; Anticonvulsants; Azepines; Benzodiazepines; Chlordiazepoxide; Diazepam; Electric Stimulation; Electroshock; Mice; Pentylenetetrazole; Pharmacology; Research; Toxicology | 1965 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice.
Topics: Animals; Anticonvulsants; Benzoquinones; Diazepam; Electroshock; Flumazenil; GABA Modulators; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Motor Activity; Nigella sativa; Pentylenetetrazole; Phytotherapy; Plant Extracts; Seeds; Seizures | 2004 |
Mouse grooming microstructure is a reliable anxiety marker bidirectionally sensitive to GABAergic drugs.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; GABA Agents; Grooming; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole | 2005 |
[A change in the alarm level entails a change in behavioural strategy of mice in stress and a change in analgesia induced by it].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Convulsants; Diazepam; Male; Mice; Pentylenetetrazole; Stress, Psychological | 2004 |
Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Gene Expression; In Situ Hybridization; Larva; Membrane Potentials; Motor Activity; Neurons; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Superior Colliculi; Time Factors; Zebrafish | 2005 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, Intraventricular; Male; Nigella; Pentylenetetrazole; Phytotherapy; Rats; Rats, Wistar; Seeds; Seizures | 2005 |
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Diazepam; Drug Design; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Mice; Models, Molecular; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 2005 |
Amiloride protects against pentylenetetrazole-induced kindling in mice.
Topics: Amiloride; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Seizures | 2005 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Mice; Pentylenetetrazole; Phenethylamines; Purinergic Agonists; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Seizures; Substance Withdrawal Syndrome; Temazepam | 2005 |
Changes in anxiety levels are followed by changes in behavioral strategy in mice subjected to stress and in the extent of stress-induced analgesia.
Topics: Adaptation, Physiological; Analgesia; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Convulsants; Diazepam; Male; Mice; Pain; Pain Threshold; Pentylenetetrazole; Stress, Psychological | 2006 |
Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Hypnotics and Sedatives; Lethal Dose 50; Magnolia; Male; Maze Learning; Mice; Pentobarbital; Pentylenetetrazole; Plant Extracts; Plant Leaves; Seizures; Sleep; Solvents; Time Factors | 2006 |
Effect of simultaneous insertion of oleaginous base on the absorption and on the anticonvulsant effect of diazepam suppository.
Topics: Animals; Anticonvulsants; Area Under Curve; Convulsants; Diazepam; Dose-Response Relationship, Drug; Intestinal Absorption; Male; Ointment Bases; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Suppositories | 2006 |
Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.
Topics: Animals; Anticonvulsants; Benzamides; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Fenclonine; Indoles; Male; Mice; Oxadiazoles; Pentylenetetrazole; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Seizures; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2006 |
Amphetamine and pentylenetetrazole given post-trial 1 enhance one-trial tolerance to the anxiolytic effect of diazepam in the elevated plus-maze in mice.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Diazepam; Drug Administration Schedule; Drug Tolerance; Maze Learning; Memory; Mice; Models, Animal; Pentylenetetrazole; Reaction Time | 2006 |
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action.
Topics: Animals; Anticonvulsants; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Disease Models, Animal; Male; Mice; Pentylenetetrazole; Seizures | 2006 |
Pharmacological and genetic influences on hole-board behaviors in mice.
Topics: Animals; Desipramine; Diazepam; Exploratory Behavior; Female; Fluoxetine; Male; Methamphetamine; Mice; Mice, Inbred Strains; Pentylenetetrazole; Piperazines; Selective Serotonin Reuptake Inhibitors | 2006 |
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
Topics: Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Convulsants; Diazepam; Electroshock; GABA-A Receptor Agonists; Ligands; Mice; Mice, Mutant Strains; Mice, Transgenic; Pentylenetetrazole; Point Mutation; Protein Subunits; Pyridines; Receptors, GABA-A; Seizures; Zolpidem | 2007 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behavior; Diazepam; Disease Models, Animal; Drug Interactions; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Spider Venoms; Spiders; Substantia Nigra; Urea | 2006 |
Pharmacological modulation of anxiety-related behaviors in the murine Suok test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Circadian Rhythm; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Exploratory Behavior; Female; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole | 2007 |
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy, Absence; Flumazenil; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Passiflora; Pentylenetetrazole; Phytotherapy; Plant Components, Aerial; Plant Extracts; Receptors, GABA-A; Receptors, Opioid; Sodium Chloride; Treatment Outcome | 2007 |
Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys.
Topics: Animals; Anticonvulsants; Clorazepate Dipotassium; Convulsants; Diazepam; Macaca mulatta; Pentylenetetrazole; Seizures; Time Factors; Treatment Outcome | 1974 |
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Oils, Volatile; Pentylenetetrazole; Phenytoin; Phytotherapy; Picrotoxin; Plant Leaves; Plant Oils; Poaceae; Seizures; Strychnine | 2008 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred CBA; Motor Activity; Pentylenetetrazole; Picrotoxin; Pyridines; Zolpidem | 2008 |
Individual differences in schedule-induced polydipsia and the role of gabaergic and dopaminergic systems.
Topics: Animals; Arousal; Brain; Cocaine; Conditioning, Operant; Dextroamphetamine; Diazepam; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drinking; GABA Antagonists; GABA Modulators; Male; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, GABA; Reinforcement Schedule | 2008 |
Adenosine receptor agonists attenuate the development of diazepam withdrawal-induced sensitization in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Convulsants; Diazepam; Hypnotics and Sedatives; Male; Mice; Pentylenetetrazole; Phenethylamines; Purinergic P1 Receptor Agonists; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 2008 |
Possible role of GABAA-benzodiazepine receptor in anticonvulsant effects of Pasipay in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Male; Passiflora; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 2008 |
Validation of anticonvulsant and sedative activity of six medicinal plants.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Hypnotics and Sedatives; Isoniazid; Male; Medicine, African Traditional; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plants, Medicinal; Sleep Initiation and Maintenance Disorders; Stereotyped Behavior; Strychnine | 2009 |
Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; GABA Agonists; GABA-A Receptor Agonists; Hypnotics and Sedatives; Locomotion; Male; Mice; Mice, Inbred CBA; Myoclonus; Pentylenetetrazole; Pyridines; Receptors, GABA-A; Seizures; Zolpidem | 2009 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Flumazenil; Lectins; Locomotion; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Reaction Time; Seeds; Seizures; Strychnine | 2009 |
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Organoselenium Compounds; Pentylenetetrazole; Pilocarpine; Quinoxalines; Rats; Rats, Wistar; Seizures; Time Factors; Treatment Outcome | 2009 |
Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cameroon; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Agonists; Fever; Hypnotics and Sedatives; Male; Mice; Motor Activity; N-Methylaspartate; Pentylenetetrazole; Plant Roots; Rubiaceae; Seizures; Sleep; Stress, Psychological; Strychnine | 2009 |
The interaction of sildenafil with the anticonvulsant effect of diazepam.
Topics: Animals; Anticonvulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Male; Mice; Nitric Oxide; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Seizures; Signal Transduction; Sildenafil Citrate; Substrate Specificity; Sulfones | 2009 |
Ayurvedic processed seeds of nux-vomica: neuropharmacological and chemical evaluation.
Topics: Aloe; Animals; Behavior, Animal; Catalepsy; Central Nervous System Agents; Diazepam; Dietary Fats; Female; Lethal Dose 50; Male; Medicine, Ayurvedic; Mice; Milk; Morphine; Motor Activity; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Seeds; Seizures; Sleep; Strychnine; Strychnos nux-vomica; Zingiber officinale | 2010 |
A rodent model of appetitive discrimination with concomitant evaluation of anxiety-like behavior.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Anxiety; Appetitive Behavior; Diazepam; Discrimination Learning; Female; GABA Antagonists; Housing, Animal; Maze Learning; Models, Animal; Neuropharmacology; Neuropsychology; Pentylenetetrazole; Rats; Rats, Wistar; Reward | 2009 |
Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Apnea; Bronchodilator Agents; Child; Convulsants; Diazepam; Dizocilpine Maleate; Fever; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; Humans; Infant; Japan; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Picrotoxin; Purinergic P1 Receptor Agonists; Saccharomyces cerevisiae; Seizures | 2009 |
Specificity of action of epileptogenic agents in diazepam-tolerant rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms | 2010 |
Anticonvulsant activity of embelin isolated from Embelia ribes.
Topics: Animals; Anticonvulsants; Benzoquinones; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Embelia; Locomotion; Pentylenetetrazole; Phenytoin; Phytotherapy; Plant Extracts; Rats; Seizures | 2011 |
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electricity; Etoricoxib; Male; Mice; Pentylenetetrazole; Phenytoin; Pyridines; Seizures; Sulfones | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rotarod Performance Test; Seizures | 2010 |
Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.
Topics: Acetylcholinesterase; Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Diazepam; Disease Models, Animal; Electroshock; Insecticides; Male; Malondialdehyde; Oxidative Stress; Pentylenetetrazole; Phosphamidon; Progesterone; Rats; Rats, Wistar; Seizures; Sulfhydryl Compounds | 2010 |
Chronic benzodiazepine treatment does not alter interactions between positive GABA(A) modulators and flumazenil or pentylenetetrazole in monkeys.
Topics: Animals; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; Macaca mulatta; Male; Midazolam; Pentylenetetrazole; Receptors, GABA-A | 2011 |
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain-Derived Neurotrophic Factor; Convulsants; Diazepam; Dizocilpine Maleate; Electrophoresis, Polyacrylamide Gel; Fear; Hippocampus; Kindling, Neurologic; Male; Matrix Metalloproteinase 9; Memory; Mice; Mice, Inbred ICR; Mice, Knockout; Microinjections; Nerve Tissue Proteins; Neuroprotective Agents; Pentylenetetrazole; Protein Kinases; Protein Precursors; Receptor, trkB; RNA, Messenger; Seizures | 2011 |
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Fatty Acids, Volatile; Flavones; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Motor Activity; Oocytes; Pentylenetetrazole; Receptors, GABA-A; Recombinant Proteins; Thiopental; Xenopus | 2011 |
Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/Benzodiazepine receptors in its pharmacological activity.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Diazepam; Exploratory Behavior; Hexobarbital; Hypericum; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pentylenetetrazole; Plant Extracts; Receptors, GABA-A; Seizures; Sleep | 2012 |
Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: protective effect of 3-alkynyl selenophene.
Topics: Animals; Anticonvulsants; Cognition Disorders; Convulsants; Diazepam; Hyperthermia, Induced; Male; Memory; Motor Activity; Organoselenium Compounds; Pentylenetetrazole; Rats; Rats, Wistar; Seizures, Febrile | 2012 |
[Adrenaline potentiates antiepileptic but not sedative action of diazepam in rats].
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Epinephrine; Gastric Mucosa; Hypnotics and Sedatives; Injections, Intramuscular; Male; Pentylenetetrazole; Rats; Seizures; Visceral Afferents | 2012 |
Synthesis and anticonvulsant activity of O-alkylated derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime.
Topics: Alkylation; Animals; Anticonvulsants; Chloroacetates; Diazepam; Imidazoles; Male; Mice; Oximes; Pentylenetetrazole; Seizures; Trichloroacetic Acid | 2012 |
Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Arachidonic Acid; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Diclofenac; Enzyme Inhibitors; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phospholipase A2 Inhibitors; Prostaglandin-Endoperoxide Synthases; Psychotropic Drugs; Quinacrine; Seizures; Substance Withdrawal Syndrome | 2012 |
Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Humans; Motor Activity; Pentylenetetrazole; Swimming; Zebrafish | 2013 |
GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy.
Topics: Animals; Anticonvulsants; Benzoates; Body Temperature Regulation; Cerebral Cortex; Diazepam; Epilepsy, Absence; Hypothermia; Male; Organophosphorus Compounds; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-B; Seizures; Sodium Oxybate | 2013 |
Ethopharmacological analysis of the open elevated plus-maze in mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Convulsants; Corticosterone; Diazepam; Factor Analysis, Statistical; Fluoxetine; Male; Maze Learning; Mice; Pentylenetetrazole; Statistics, Nonparametric; Yohimbine | 2013 |
Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy.
Topics: Animals; Anticonvulsants; Brain; Brain Waves; Cerebral Cortex; Diazepam; Drug Synergism; Epilepsies, Partial; Free Radical Scavengers; Kindling, Neurologic; Male; Penicillins; Pentoxifylline; Pentylenetetrazole; Rats; Rats, Wistar | 2013 |
Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Uptake Inhibitors; Kindling, Neurologic; Male; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Spider Venoms; Urea | 2013 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; Hypothalamus; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Nerve Tissue Proteins; Pentylenetetrazole; Polymorphism, Single Nucleotide; Psychomotor Performance; Seizures; Sex Factors; Substance-Related Disorders | 2013 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; gamma-Aminobutyric Acid; Heterocyclic Compounds, 3-Ring; Hypnotics and Sedatives; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Psychomotor Performance; Seizures; Sleep | 2013 |
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Electroencephalography; Emotions; GABA Antagonists; GABA Modulators; Hippocampus; Male; Maze Learning; Pentylenetetrazole; Pilocarpine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, GABA-A; Theta Rhythm | 2013 |
Mygalin: a new anticonvulsant polyamine in acute seizure model and neuroethological schedule.
Topics: Acute Disease; Animals; Anticonvulsants; Cognition; Diazepam; Dizocilpine Maleate; Drug Evaluation, Preclinical; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Exploratory Behavior; Locomotion; Male; Maze Learning; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Rotarod Performance Test; Spermidine | 2013 |
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Knockdown Techniques; Pentylenetetrazole; Potassium Channels, Inwardly Rectifying; Seizures; Zebrafish | 2013 |
Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model.
Topics: Animals; Anticonvulsants; Clomiphene; Convulsants; Diazepam; Disease Models, Animal; Estriol; Female; Hand Strength; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures | 2014 |
Plurality of anxiety and depression alteration mechanism by oleanolic acid.
Topics: alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Hippocampus; Imipramine; Male; Mice; Monoamine Oxidase; Motor Activity; Oleanolic Acid; Pentylenetetrazole; Piperazines; Pyridines | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethosuximide; Flumazenil; Juglans; Male; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Seizures | 2014 |
Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Lythraceae; Male; Mice; Pentylenetetrazole; Phytotherapy; Plant Extracts; Random Allocation; Seeds; Seizures; Strychnine; Treatment Outcome | 2015 |
Pharmacological validation of the free-exploratory paradigm in male Wistar rats: A proposed test of trait anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Drug Evaluation, Preclinical; Exploratory Behavior; Fluoxetine; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Wistar | 2015 |
Anticonvulsant activity of methanolic extract from Kalanchoe pinnata Lam. stems and roots in mice: A comparison to diazepam.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Female; Kalanchoe; Male; Methanol; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Plant Extracts; Plant Roots; Plant Stems; Seizures; Solvents | 2016 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Male; Mice; Oxidation-Reduction; Oxygen Consumption; Pentylenetetrazole; Phenytoin; Seizures; Time Factors; Valproic Acid | 2015 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagonists; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Piracetam; Rats; Seizures; Status Epilepticus; Valproic Acid | 2016 |
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; Diazepam; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Pilocarpine; Reaction Time; Rosmarinic Acid; Seizures; Sleep; Time Factors | 2016 |
Dantrolene: A Selective Ryanodine Receptor Antagonist, Protects Against Pentylenetetrazole-Induced Seizure in Mice.
Topics: Animals; Anticonvulsants; Dantrolene; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Ryanodine Receptor Calcium Release Channel; Seizures | 2016 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nifedipine; Pentylenetetrazole; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley | 2017 |
Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats.
Topics: Animals; Anticonvulsants; Diazepam; Epilepsy; Flumazenil; Hippocampus; Male; Microinjections; Oxytocics; Oxytocin; Pentylenetetrazole; Rats; Tocolytic Agents; Vasotocin | 2017 |
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Male; Mice, Inbred BALB C; Pentylenetetrazole; Seizures; Thiamine | 2019 |
NMDA Receptors and NO:cGMP Signaling Pathway Mediate the Diazepam-Induced Sensitization to Withdrawal Signs in Mice.
Topics: Animals; Benzodiazepines; Cyclic GMP; Diazepam; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substance Withdrawal Syndrome | 2018 |
The Roman high- and low-avoidance rats differ in the sensitivity to shock-induced suppression of drinking and to the anxiogenic effect of pentylenetetrazole.
Topics: Animals; Animals, Outbred Strains; Avoidance Learning; Behavior, Animal; Diazepam; Drinking; Electric Stimulation; Male; Pentylenetetrazole; Punishment; Rats; Rats, Inbred Strains; Species Specificity | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Kainic Acid; Male; Malondialdehyde; Maze Learning; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Phenytoin; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Seizures; Sesquiterpenes; Status Epilepticus | 2018 |
Clarified Açaí (
Topics: Animals; Anticonvulsants; Cells, Cultured; Complex Mixtures; Diazepam; Disease Models, Animal; Euterpe; Fruit and Vegetable Juices; GABA Agents; Mice; Mice, Inbred Strains; Neurons; Pentylenetetrazole; Seizures; Synaptic Transmission | 2018 |
Taurine Protects from Pentylenetetrazole-Induced Behavioral and Neurochemical Changes in Zebrafish.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Brain Chemistry; Cell Death; Cell Survival; Diazepam; Female; Male; Neurochemistry; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Phenotype; Protein Carbonylation; Seizures; Swimming; Taurine; Thiobarbituric Acid Reactive Substances; Zebrafish | 2019 |
Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.
Topics: Administration, Inhalation; Albuterol; Animals; Atropine; Bronchodilator Agents; Convulsants; Diazepam; Epilepsy; Ipratropium; Isoflurophate; Male; Pentylenetetrazole; Rats; Respiration Disorders; Respiratory Mechanics; Seizures | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2018 |
Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Electrophorus; Female; Horses; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Thiophenes | 2019 |
Garlic passion fruit (Passiflora tenuifila Killip): Assessment of eventual acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Fluoxetine; Fruit; Mice; Motor Activity; Passiflora; Pentylenetetrazole; Plant Extracts; Seizures | 2020 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Male; Mice; Nitric Oxide; Oils, Volatile; Pentylenetetrazole; Plant Leaves; Plant Oils; Salvia; Seizures; Synaptic Transmission | 2020 |
Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Inflammation; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Transcranial Direct Current Stimulation | 2020 |
Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebellum; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentylenetetrazole; Rats, Wistar; Seizures | 2020 |
Micronized Resveratrol Shows Anticonvulsant Properties in Pentylenetetrazole-Induced Seizure Model in Adult Zebrafish.
Topics: Animals; Anticonvulsants; Diazepam; Female; Locomotion; Male; Particle Size; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Resveratrol; Seizures; Zebrafish | 2021 |
Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Molecular Docking Simulation; Monoterpenes; Patient Acuity; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mice; Pentylenetetrazole; Phytochemicals; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Psychotria; Rats, Wistar; Seizures; Semicarbazides; Sleep; Sleep Latency; Strychnine; Water | 2021 |
Effects of probiotics on pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Diazepam; Mice; Pentylenetetrazole; Probiotics; Seizures | 2021 |
Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum.
Topics: Animals; Anticonvulsants; Brain; Characiformes; Diazepam; Diet; Euterpe; Lipid Peroxidation; Pentylenetetrazole; Seizures; Thiobarbituric Acid Reactive Substances | 2021 |
Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio).
Topics: Animals; Anticonvulsants; Caspase 3; Diazepam; Epilepsy; Interleukin-1beta; Neuroprotective Agents; Pentylenetetrazole; Resveratrol; Seizures; Stilbenes; Zebrafish | 2022 |
Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice.
Topics: Animals; Benzodiazepines; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Diazepam; Electroencephalography; Humans; Indazoles; Indoles; Male; Mice; Naphthalenes; Pentylenetetrazole; Receptor, Cannabinoid, CB1; Rimonabant; Seizures; Substance-Related Disorders; Valine | 2022 |
Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Capsaicin; Diazepam; Endocannabinoids; Mice; Pentylenetetrazole; Polyunsaturated Alkamides; Seizures; TRPV Cation Channels | 2022 |
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise; Hippocampus; Interleukin-10; Pentylenetetrazole; Seizures; Tumor Necrosis Factor-alpha | 2022 |
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2022 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; NF-kappa B; Pentylenetetrazole; Rats; Seizures | 2023 |
In vitro and in vivo anti-seizure activity of hydromethanolic extract and fractions of Pterolobium stellatum.
Topics: Animals; Anticonvulsants; Butanols; Chloroform; Chromatography, Liquid; Diazepam; Ellagic Acid; Ethiopia; Kaempferols; Methanol; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Phenytoin; Plant Extracts; Solvents; Tandem Mass Spectrometry; Water | 2023 |
Neuroprotective anticonvulsant and anxiolytic effects of octreotide in wistar rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Male; Mice; Neuroprotective Agents; Octreotide; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Somatostatin | 2023 |
Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility.
Topics: Animals; Anticonvulsants; Diazepam; Humans; Male; Pentylenetetrazole; Phenobarbital; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Seizures; Sildenafil Citrate; Sulfones; Tadalafil | 2023 |