pentylenetetrazole has been researched along with bicuculline in 201 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 106 (52.74) | 18.7374 |
| 1990's | 45 (22.39) | 18.2507 |
| 2000's | 36 (17.91) | 29.6817 |
| 2010's | 12 (5.97) | 24.3611 |
| 2020's | 2 (1.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Carcache, D; Kalkman, HO; Koller, M; Mattes, H | 1 |
| Javid, MJ; Stone, WE | 2 |
| Bernardo, K; Keenan, L; Koopowitz, H | 1 |
| Fukushima, H; Nakamura, M | 1 |
| Matthews, WD; McCafferty, GP | 1 |
| Stone, WE | 1 |
| Franco, S; Schlosser, W | 1 |
| Barker, JL; Macdonald, RL | 1 |
| Bigler, ED | 2 |
| Gartside, IB; Hayes, AG; Straughan, DW | 1 |
| Lippa, AS; Regan, B | 1 |
| Feldberg, W; Rocha e Silva, M | 1 |
| Greenlee, D; Olsen, RW; Ticku, MK; Van Ness, PC | 1 |
| Kaplan, BJ; Williamson, PD | 1 |
| Simmonds, MA | 2 |
| Bianchi, M; Galzigna, L; Garbin, L; Marzotto, A | 1 |
| Frey, HH; Löscher, W | 1 |
| Gardner, CR; Webster, RA | 1 |
| Mulas, A; Pedata, F; Pepeu, G; Pepeu, IM | 1 |
| Brierley, JB; Meldrum, BS; Papy, JJ; Toure, MF | 1 |
| Lin, WC; Watanabe, K; Yano, S | 3 |
| Daval, JL; el Hamdi, G; Nehlig, A; Pereira de Vasconcelos, A; Werck, MC | 1 |
| Mathé, AA; Stenfors, C; Theodorsson, E | 1 |
| Rosenberg, HC; Weng, X | 1 |
| Golovenko, NIa; Zhuk, OV; Zin'kovskiĭ, VG | 4 |
| Diamantis, W; Gels, M; Gordon, R; Sofia, RD | 1 |
| de Feo, MR; Mecarelli, O; Ricci, G; Rina, MF | 1 |
| Faktorová, M; Kubová, H; Mares, P | 1 |
| Petersen, EN | 1 |
| Bardgett, ME; Gray, BC; Miller, JW | 1 |
| Arnoldi, A; Bonsignori, A; Melloni, P; Merlini, L; Quadri, ML; Varasi, M | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Abdikaliev, NA; Mdzinarishvili, AL; Meerson, FZ; Pshennikova, MG; Voronina, TA | 1 |
| Bastide, J; Bastide, P; Coudert, P; Couquelet, JM; Rubat, C; Tronche, P | 1 |
| Kaya, M; Oztaş, B | 1 |
| Simmet, T; Tippler, B | 1 |
| Mares, P; Rokyta, R; Velísek, L; Velísková, J | 1 |
| Coulter, DA; Huguenard, JR; Prince, DA | 1 |
| Bohuslav, T; Kubová, H; Mares, P | 1 |
| Ferrendelli, JA; Miller, JW | 1 |
| Campbell, JA; Greenwood, TD; Rathman, TL; Sleevi, MC; Wolfe, JF | 1 |
| Binnie, CD; Van Emde Boas, W; Wauquier, A | 1 |
| Albertson, TE; Joy, RM | 1 |
| Alpern, HP; McIntyre, TD | 3 |
| Sedlácek, J | 3 |
| Kumasaka, Y; Ueki, S; Yamamoto, T | 1 |
| Jackson, BW; Lewin, AH; Marvizón, JC; Monn, JA; Rice, KC; Skolnick, P | 1 |
| Nagaya, H; Negishi, N; Okada, R | 1 |
| Bhadra, S; Idemudia, SO; Lal, H | 1 |
| Georgieva, J | 1 |
| Halsey, MJ; Little, HJ; Wardley-Smith, B | 1 |
| Hodin, RA; Kreisman, NR; Rosenthal, M; Sick, TJ | 1 |
| Golovenko, NIa; Zhuk, OV; Zin'kovskiiĭ, VG | 1 |
| Hara, S; Morioka, S; Satoh, K; Yanagihara, S | 1 |
| Fujii, E; Nomoto, T | 1 |
| Collingridge, GL; Herron, CE; Williamson, R | 1 |
| McCaslin, PP; Morgan, WW | 1 |
| Kent, AP; Webster, RA | 1 |
| Faraci, FM; Heistad, DD; Motley, MG | 1 |
| Anderson, MC; Chung, EY; Van Woert, MH | 1 |
| Fletcher, A; Forster, EA | 1 |
| Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS | 1 |
| Lloyd, KG | 1 |
| Little, H; Nutt, DJ | 1 |
| Biggio, G; Corda, MG | 1 |
| Little, HJ; Nutt, DJ; Taylor, SC | 1 |
| Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A | 1 |
| Georgiev, VP; Kambourova, TS; Petkov, VD; Petkova, BP | 1 |
| Laporte, AM; Soubrié, P; Thiébot, MH | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Lister, RG; Nutt, DJ | 1 |
| Crider, AM; Hinko, CN; Wood, JD | 1 |
| Ferrendelli, JA; Mirski, MA | 1 |
| Goping, G; Klatzo, I; Nitsch, C | 1 |
| Piredda, SG; Swinyard, EA; Woodhead, JH | 1 |
| Hinko, CN; Lee, JA; Moore, JA; Nicholson, JM; Scott, KR; Zalucky, TB | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J | 1 |
| Anderson, RE; Meyer, FB; Sharbrough, FW; Sundt, TM | 1 |
| Cross, RS; Giesler, M; Nelson, SR; Pazdernik, TL; Samson, FE | 1 |
| Kupferberg, HJ; Swinyard, EA | 1 |
| Higashio, T; Inukai, T; Nakao, K | 1 |
| Cowen, PJ; Green, AR; Nutt, DJ | 2 |
| Malick, JB; Patel, JB | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L | 2 |
| Miyamoto, M; Nagawa, Y; Saji, Y; Shintani, M | 1 |
| Goitein, KJ; Shohami, E | 1 |
| Zetler, G | 1 |
| Batts, CC; Cowen, PJ; Grahame-Smith, DG; Green, AR; Nutt, DJ | 1 |
| Albertson, TE; Bowyer, JF | 1 |
| Engel, J; Liljequist, S | 1 |
| Feldman, RS; McElroy, JF | 1 |
| Blavet, N; DeFeudis, FV | 1 |
| Aleman, V; de Muñoz, DM | 1 |
| Mauss, EA; Wallenstein, MC | 1 |
| Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G | 1 |
| Sarhan, S; Seiler, N | 1 |
| Crider, AM; Hinko, CN; Seibert, K | 1 |
| Barker, JL; Mathers, DA; McBurney, RN | 1 |
| Barris, D; Cordi, A; Roba, J; van Dorsser, W | 1 |
| Bourgeois, BF; Dodson, WE; Ferrendelli, JA | 1 |
| Colombo, R; Ossi, C; Pinelli, A; Spazzi, L; Tofanetti, O | 1 |
| Clark, CR; Dockens, RC; Norris, GN; Ravis, WR; Sansom, RT; Wells, MJ | 1 |
| Fujiwara, K; Klatzo, I; Kuroiwa, T; Nitsch, C | 1 |
| Kharlamov, AN; Raevskiĭ, KS | 1 |
| Batts, CC; Cowen, PJ; Green, AR; Heal, DJ; Nutt, DJ | 1 |
| Chodkowska, A; Kleinrok, Z; Sieklucka-Dziuba, M | 1 |
| Scholfield, CN | 1 |
| Gale, K; Iadarola, MJ | 1 |
| Costa, LG; Doctor, SV; Murphy, SD | 1 |
| Crider, AM; Hinko, CN; Tita, TT; Wood, JD | 1 |
| Ben-Ari, Y; Charton, G; Riche, D; Tremblay, E | 1 |
| Ben-Ari, Y; Ghilini, G; Naquet, R; Riche, D; Tremblay, E | 1 |
| Pizzi, WJ; Unnerstall, JR | 1 |
| Davis, W; Penix, LP; Subramaniam, S | 1 |
| Bailleux, V; Hamoir, G; Nuyts, JP; Poupaert, JH; Stables, JP; Vallée, L; Vamecq, J | 1 |
| de Feo, MR; Del Priore, D; Mecarelli, O | 1 |
| Dunham, L; Guillet, R | 1 |
| Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B | 1 |
| Ahmad, I; Lauretti, GR; Pleuvry, BJ | 1 |
| Getova, DP; Maslarova, JE; Nikolov, RK; Semkova, IS | 1 |
| Sowell, KL; Stringer, JL | 1 |
| Blisard, KS; Fagin, K; Falivena, P; Harrington, DA; Olejniczak, P; Privitera, MD; Scremin, OU; Taylor, KL | 1 |
| Fiakpui, CY; Knaus, EE | 1 |
| Bingmann, D; Bonnet, U | 1 |
| Guiol, C; Ledoussal, C; Surgé, JM | 1 |
| Kozicka, M | 1 |
| Bartsch, R; Engel, J; Hönack, D; Kutscher, B; Löscher, W; Polymeropoulos, EE; Rostock, A; Rundfeldt, C; Tober, C; White, HS; Wolf, HH | 1 |
| Barrett, JA; Dixon, KD; Gietzen, DW; Jones, AC; Truong, BG; Washburn, DS | 1 |
| Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD | 1 |
| Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T | 1 |
| Miyakawa, T; Niki, H; Tateishi, K; Yagi, T | 1 |
| Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T | 1 |
| Almond, HR; Carmosin, RJ; Carson, JR; Pitis, PM; Stables, JP; Swinyard, EA; Vaught, JL; White, HS; Wolf, HH | 1 |
| Chunngam, T; Patarapanich, C; Sooksawate, T; Tantisira, B; Tantisira, MH | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Fukuda, T; Minami, E; Nomoto, M; Nunoura, Y; Shibata, H | 1 |
| Easton, A; Gale, K; Walker, BR | 1 |
| Aizenman, E; Gardner, G; Jensen, FE; Orlando, L; Rosenberg, PA; Sanchez, RM; Tauck, DL; Wang, C | 1 |
| Cole, TB; Palmiter, RD; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Chae, WG; Choi, H; Choi, J; Jahng, Y; Je, SM; Kim, EK; Kim, TH; Kim, YC; Lee, ES; Park, M; Zhao, LX | 1 |
| Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT | 1 |
| Choudhary, MI; DeLorenzo, RJ; Rahman, AU; Raza, M; Shaheen, F; Sombati, S; Suria, A | 1 |
| Choudhary, MI; DeLorenzo, RJ; Rafiq, A; Rahman, A; Raza, M; Shaheen, F; Sombati, S; Suria, A | 1 |
| Burnashev, N; Bushell, TJ; Clarke, VR; Collett, VJ; Collingridge, GL; Duvoisin, RM; Flor, PJ; Gasparini, F; Hampson, DR; Klebs, K; Knoepfel, T; Kuhn, R; Portet, C; Rozov, A; Sansig, G; Schmutz, M; Schroeder, M; Shigemoto, R; van Der Putten, H; Zhang, C | 1 |
| Gustaw, K; Rubaj, A; Sieklucka-Dziuba, M; Zgodzinski, W | 1 |
| Little, HJ; Watson, WP | 1 |
| Barton, ME; Bennett, GD; Bialer, M; Finnell, RH; Isoherranen, N; White, HS; Wilcox, KS; Woodhead, JH; Yagen, B | 1 |
| Hamann, M; Richter, A | 1 |
| Amabeoku, GJ; Bienvenu, E; Eagles, PK; Scott, G; Springfield, EP | 1 |
| Berkovic, SF; Clark, M; Drago, J; Finkelstein, DI; Horne, MK; Massalas, JS; McColl, C; Powney, E; Ross, SA; Wong, JY | 1 |
| Gatch, MB; Jung, ME; Lal, H; Wallis, CJ | 1 |
| Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H | 1 |
| Choudhary, MI; DeLorenzo, RJ; Rahman, AU; Raza, M; Shaheen, F; Sombati, S | 1 |
| Bureau, Y; McIntyre, DC; Racine, RJ; Steingart, M | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Frye, CA; Rhodes, ME | 1 |
| Forster, MJ; Gatch, MB; Selvig, M | 1 |
| Gal, A; Hentschke, M; Hentschke, S; Hermans-Borgmeyer, I; Hübner, CA; Jentsch, TJ; Kurth, I; Seidenbecher, T; Wiemann, M | 1 |
| Ojewole, JA | 4 |
| Dehpour, AR; Ebrahimi, F; Homayoun, H; Rafiei-Tabatabaei, N; Riazi, K; Roshanpour, M | 1 |
| Dimpfel, W | 1 |
| Amabeoku, GJ; Ojewole, JA | 1 |
| Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR | 1 |
| Amabeoku, GJ; Green, I; Kabatende, J | 1 |
| Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS | 1 |
| Kubová, H; Mares, P; Tchekalarova, J | 1 |
| Andreev, AA; Kalinina, MV; Karpova, MN; Klishina, NY; Kuznetsova, LV; Rebrov, IG | 1 |
| Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ | 1 |
| Amabeoku, G | 1 |
| Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG | 1 |
| Paz, C; Retana-Márquez, S; Rubio, C; Rubio-Osornio, M; Verónica Custodio, ML | 1 |
| Haghdoost-Yazdi, H; Janahmadi, M; Rajaei, F | 1 |
| Beleboni, RO; Cunha, AO; dos Santos, WF; Fachim, HA; Faggion, SA; Gavin, AS; Pereira, AM | 1 |
| Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX | 1 |
| Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M | 1 |
| Buhler, E; Chauvin, Y; Jalabert, M; Malvache, A; Manent, JB; Peret, A; Petit, LF; Represa, A; Watrin, F | 1 |
| Kubová, H; Mareš, P | 1 |
| Guan, LP; Jin, P; Li, FN; Quan, ZS; Wang, SB; Zhang, HJ | 1 |
| Dambrova, M; Lauberte, L; Misane, I; Stonans, I; Svalbe, B; Vavers, E; Zvejniece, L | 1 |
| Josiane Ojong, L; Jules Fifen, J; Kameni Njapdounke, JS; Kavaye Kandeda, A; Ngo Bum, E; Nkamguie Nkantchoua, GC; Sotoing Taiwe, G | 1 |
| Dambrova, M; Kupats, E; Lauberte, L; Mezapuke, R; Stelfa, G; Svalbe, B; Vavers, E; Vilks, K; Zvejniece, B; Zvejniece, L | 1 |
| An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y | 1 |
3 review(s) available for pentylenetetrazole and bicuculline
| Article | Year |
|---|---|
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Nerve Endings; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 1986 |
[2 types of effects of convulsants on the embryonic CNS].
Topics: Animals; Bicuculline; Central Nervous System; Chick Embryo; Convulsants; Methionine Sulfoximine; Movement; Oxotremorine; Penicillins; Pentylenetetrazole; Picrotoxin; Strychnine; Tetanus Toxin | 1985 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Epilepsy, Reflex; Flurothyl; gamma-Aminobutyric Acid; Humans; Kainic Acid; Kindling, Neurologic; Muscarinic Agonists; Papio; Penicillins; Pentylenetetrazole; Pilocarpine; Tetanus Toxin; Zinc Compounds | 2010 |
198 other study(ies) available for pentylenetetrazole and bicuculline
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.
Topics: Analgesics; Animals; Anticonvulsants; Antipsychotic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Protein Subunits; Receptors, AMPA | 2010 |
Benzodiazepines and phenobarbital as antagonists of dissimilar chemical convulsants.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Picrotoxin; Therapeutic Equivalency | 1978 |
Primitive nervous systems: action of aminergic drugs and blocking agents on activity in the ventral nerve cord of the flatworm Notoplana acticola.
Topics: Animals; Bicuculline; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Neurons; Neurotransmitter Agents; Pentylenetetrazole; Peripheral Nerves; Picrotoxin; Platyhelminths | 1979 |
Effect of benzodiazepines on central serotonergic neuron systems.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Cyproheptadine; Diazepam; Drug Interactions; In Vitro Techniques; Male; Mescaline; Mice; Muscle Contraction; Neurons; Pentylenetetrazole; Postural Balance; Rats; Serotonin; Synaptic Transmission; Synaptosomes; Time Factors | 1977 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Synaptic Transmission | 1979 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid | 1977 |
Reduction of gamma-aminobutyric acid (GABA)-mediated transmission by a convulsant benzodiazepine.
Topics: Animals; Benzodiazepinones; Bicuculline; Cats; Convulsants; Female; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pentylenetetrazole; Picrotoxin; Reflex; Spinal Cord; Strychnine | 1979 |
Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action.
Topics: Amino Acids; Aminobutyrates; Animals; Bicuculline; Convulsants; Culture Techniques; gamma-Aminobutyric Acid; Iontophoresis; Mice; Neural Inhibition; Neurons; Penicillins; Pentylenetetrazole; Picrotoxin; Spinal Cord | 1978 |
Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Light; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Visual Cortex | 1977 |
Effect of four convulsants on the time course of presynaptic inhibition and the relation to seizure activity.
Topics: Animals; Bemegride; Bicuculline; Cerebral Cortex; Convulsants; Instinct; Male; Medulla Oblongata; Neural Inhibition; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1977 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Male; Mice; Pentylenetetrazole; Seizures; Strychnine | 1977 |
Vasopressin release produced in anaesthetized cats by antagonists of gamma-aminobutyric acid and glycine.
Topics: Aminobutyrates; Anesthesia; Animals; Bicuculline; Blood Pressure; Cats; GABA Antagonists; Glycine; Medulla Oblongata; Pentylenetetrazole; Picrotoxin; Strychnine; Time Factors; Tubocurarine; Vasopressins | 1978 |
Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro.
Topics: Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Imipramine; In Vitro Techniques; Male; Mice; Penicillin G; Pentylenetetrazole; Picrotoxin; Receptors, Drug; Synaptosomes | 1978 |
Electroencephalogram and somatosensory evoked potential changes after administration of six convulsant drugs.
Topics: Animals; Bemegride; Bicuculline; Cats; Convulsants; Electroencephalography; Evoked Potentials; Glycine; Pentylenetetrazole; Picrotoxin; Somatosensory Cortex; Strychnine; Time Factors | 1978 |
Presynaptic actions of gamma-aminobutyric acid and some antagonists in a slice preparation of cuneate nucleus.
Topics: Aminobutyrates; Animals; Bemegride; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; In Vitro Techniques; Male; Medulla Oblongata; Neuromuscular Depolarizing Agents; Pentylenetetrazole; Potassium; Rats; Strychnine | 1978 |
Properties of two derivatives of gamma-aminobutyric acid (GABA) capable of abolishing Cardiazol- and bicuculline-induced convulsions in the rat.
Topics: Animals; Bicuculline; Brain; Chemical Phenomena; Chemistry, Physical; Female; gamma-Aminobutyric Acid; Isoquinolines; Male; Mitochondria; Pentylenetetrazole; Rats; Seizures | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; Drug Interactions; Electroencephalography; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Time Factors; Trimethadione | 1977 |
Bicuculline potentiation of photically evoked after-discharges.
Topics: Animals; Bicuculline; Evoked Potentials; Isoquinolines; Pentylenetetrazole; Photic Stimulation; Rats; Stimulation, Chemical | 1977 |
Changes in regional brain acetylcholine levels during drug-induced convulsions.
Topics: Acetylcholine; Animals; Bicuculline; Brain Chemistry; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine | 1976 |
Four models for studying cerebral lesions secondary to epileptic seizures.
Topics: Animals; Astrocytes; Bicuculline; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperature; Cerebellum; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Gallamine Triethiodide; Gliosis; Glycine; Hippocampus; Ischemia; Papio; Pentylenetetrazole; Purkinje Cells | 1975 |
Involvement of central GABAA receptor complex in controlling the basal gastric secretory activity in pylorus-ligated rats.
Topics: Analysis of Variance; Anesthesia; Animals; Bicuculline; Diazepam; Gastric Acid; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
Quantitative autoradiographic measurements of functional changes induced by generalized seizures in the developing rat brain: central adenosine and benzodiazepine receptors and local cerebral glucose utilization.
Topics: Age Factors; Animals; Autoradiography; Bicuculline; Blood Glucose; Brain; Brain Mapping; Epilepsy, Generalized; gamma-Aminobutyric Acid; Hippocampus; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Purinergic; Seizures; Status Epilepticus | 1992 |
Brain neuropeptides: changes by treatment with the convulsants pentylenetetrazole and bicuculline.
Topics: Animals; Bicuculline; Brain Chemistry; Electroshock; Male; Neuropeptides; Pentylenetetrazole; Radioimmunoassay; Rats; Rats, Inbred Strains | 1992 |
Infusion of bicuculline methiodide into the tectum: model specificity of pro- and anticonvulsant actions.
Topics: Animals; Behavior, Animal; Bicuculline; Electroshock; Male; Microinjections; Models, Neurological; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Superior Colliculi | 1992 |
[Effector modeling of the action of ligands of the GABA receptor complex: functional interactions of muscimol and exogenous modulators of the complex].
Topics: Animals; Anti-Anxiety Agents; Barbital; Benzodiazepines; Benzodiazepinones; Bicuculline; Ligands; Male; Mice; Muscimol; Pentylenetetrazole; Receptors, GABA-A; Semicarbazides | 1991 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A Receptor Antagonists; Isoniazid; Male; Mice; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Seizures | 1991 |
Effects of carbamazepine on bicuculline- and pentylenetetrazol-induced seizures in developing rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Carbamazepine; Epilepsy; Female; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1991 |
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Selective protection by adenosine receptor agonists against DMCM-induced seizures.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Female; Mice; Pentylenetetrazole; Phenylisopropyladenosine; Receptors, Purinergic; Seizures; Theophylline | 1991 |
The role of the laterodorsal tegmental nucleus of the rat in experimental seizures.
Topics: Alcian Blue; Animals; Baclofen; Bicuculline; Female; Histocytochemistry; In Vitro Techniques; Microinjections; Pentylenetetrazole; Piperidines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Tegmentum Mesencephali; Thalamic Nuclei | 1991 |
Synthesis and anticonvulsant activity of some benzopyranone imino derivatives of GABA and related compounds.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Chromans; gamma-Aminobutyric Acid; Imines; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Rats | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
[Comparative evaluation of anticonvulsant and anti-arrhythmic effects of phenazepam, a benzodiazepine receptor agonist].
Topics: Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Bicuculline; Heart; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Thiosemicarbazones | 1990 |
Synthesis and pharmacological evaluation of 6,8-diaryl 1,2,4-triazolo [4,3,-b] and 1,2,3,4,-tetrazolo [1,5-b] pyridazines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azoles; Behavior, Animal; Bicuculline; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and Sedatives; Mice; Motor Activity; Pentylenetetrazole; Pyridazines; Seizures; Tetrazoles; Triazoles | 1990 |
The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures.
Topics: Acute Disease; Albumins; Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Evans Blue; Female; Hypertension; Male; Mesencephalon; Pentylenetetrazole; Permeability; Rats; Rats, Inbred Strains; Seizures; Thalamus | 1991 |
On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures.
Topics: Animals; Bicuculline; Brain; Dinoprost; Epilepsy; Gerbillinae; Handling, Psychological; Kinetics; Pentylenetetrazole; Seizures; SRS-A | 1991 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Absence; Ethosuximide; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Succinimides; Thalamus | 1990 |
Anticonvulsant effects of clonazepam on chemically induced convulsions.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Clonazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1990 |
Characterization of GABAergic seizure regulation in the midline thalamus.
Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobutyric Acid; Pentobarbital; Pentylenetetrazole; Piperidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamic Nuclei | 1990 |
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Lethal Dose 50; Male; Methaqualone; Mice; Molecular Structure; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine | 1990 |
Geniculate spikes during epileptic seizures induced in dogs by pentylenetetrazol and bicuculline.
Topics: Animals; Bicuculline; Brain Stem; Dogs; Electroencephalography; Epilepsies, Partial; Evoked Potentials; Female; Frontal Lobe; Geniculate Bodies; Hippocampus; Occipital Lobe; Pentylenetetrazole; Photic Stimulation; Reaction Time | 1985 |
Convulsant-induced changes in perforant path-dentate gyrus excitability in urethane anesthetized rats.
Topics: Animals; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Hexachlorocyclohexane; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Female; Flumazenil; Male; Mice; Pentylenetetrazole; Phenobarbital; Reaction Time; Seizures; Sleep | 1989 |
Effects of the acute and chronic administration of chlordiazepoxide on the development of spontaneous motility in chick embryos.
Topics: Animals; Bicuculline; Chick Embryo; Chlordiazepoxide; gamma-Aminobutyric Acid; Movement; Pentylenetetrazole; Picrotoxin; Strychnine; Time Factors | 1989 |
[Effector modelling of the action of ligands of the GABA-receptor complex, cooperativity of the processes and the type of modification of the complex by convulsants and their reversible agonists].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbital; Bemegride; Benzodiazepines; Benzodiazepinones; Bicuculline; Convulsants; Drug Interactions; Female; Ligands; Mathematics; Mice; Mice, Inbred CBA; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1989 |
[Effector modeling of the action of ligands of GABA-receptor complex. Functional interaction of the hypothetic alcohol receptor with other subunits of the complex].
Topics: 1-Propanol; Alcohols; Animals; Barbiturates; Bemegride; Bicuculline; Butanols; Ethanol; Female; Methanol; Mice; Mice, Inbred CBA; Models, Biological; Pentanols; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Semicarbazides | 1989 |
Behavioral analysis of zopiclone on the basis of their discriminative stimulus properties in the rat.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Behavior, Animal; Benzodiazepines; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Hypnotics and Sedatives; Male; Muscimol; Naphthyridines; Pentylenetetrazole; Piperazines; Piperidines; Rats; Rats, Inbred WKY; Ritanserin; Serotonin Antagonists; Sulfur Compounds | 1989 |
Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Anticonvulsants; Aspartic Acid; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Strychnine; Synaptic Membranes | 1989 |
The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Pons; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Superior Colliculi | 1989 |
Inhibitory effect of intravenous GABA antagonists on gastric acid secretion stimulated by secretagogues in rats.
Topics: Animals; Bethanechol Compounds; Bicuculline; Deoxyglucose; GABA Antagonists; Gastric Acid; Injections, Intravenous; Male; Paralysis; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord Injuries; Stomach; Strychnine; Tubocurarine | 1989 |
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Sesterterpenes; Substance Withdrawal Syndrome | 1989 |
Effects of the diterpene sclareol glycol on convulsive seizures.
Topics: Animals; Bicuculline; Colforsin; Convulsants; Diterpenes; Drug Synergism; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1989 |
Systemically administered glycine protects against strychnine convulsions, but not the behavioural effects of high pressure, in mice.
Topics: Animals; Atmospheric Pressure; Bicuculline; Dose-Response Relationship, Drug; Glycine; High Pressure Neurological Syndrome; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Strychnine; Time Factors | 1989 |
Role of pulmonary edema in phasic changes of cerebral oxygenation during serial seizures.
Topics: Animals; Bicuculline; Brain; Electron Transport Complex IV; Hemodynamics; Hydrogen-Ion Concentration; Male; Oxygen Consumption; Pentylenetetrazole; Pulmonary Edema; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1987 |
[Effector modeling of the action of GABA-receptor complex ligands. Functional interactions of subunits of the complex].
Topics: Animals; Barbital; Benzodiazepines; Bicuculline; Dose-Response Relationship, Drug; Ligands; Male; Mice; Mice, Inbred CBA; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors.
Topics: Animals; Anticonvulsants; Atropine; beta-Alanine; Bicuculline; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Indomethacin; Male; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stomach Ulcer; Taurine | 1988 |
[Effector modeling of the effect of ligands of GABA receptor complex. Modification of conformation states of the complex by combined administration of benzodiazepines and barbiturates].
Topics: Animals; Anti-Anxiety Agents; Barbital; Barbiturates; Benzodiazepines; Benzodiazepinones; Bicuculline; Diazepam; Drug Antagonism; Female; Ligands; Mice; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
[Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the mice].
Topics: Animals; Bicuculline; Convulsants; Drug Synergism; Male; Mice; Morphine; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Epilepsy; Evoked Potentials; Female; Folic Acid Antagonists; Hippocampus; In Vitro Techniques; Magnesium; Pentylenetetrazole; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1985 |
Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Barbiturates; Bicuculline; Brain; Brain Chemistry; Cyclic GMP; Female; Injections, Intraventricular; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
Activation of a cranial vasodilator pathway during seizures in rats.
Topics: Animals; Atropine; Bicuculline; Cerebrovascular Circulation; Hexamethonium; Hexamethonium Compounds; Male; Microspheres; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Spinal Cord; Sympathetic Nervous System; Vasodilation | 1986 |
Effect of inferior olive lesion on seizure threshold in the rat.
Topics: Animals; Bicuculline; Cerebellum; Convulsants; Male; Motor Activity; Neural Pathways; Olivary Nucleus; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Seizures; Strychnine | 1987 |
A proconvulsant action of selective alpha 2-adrenoceptor antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Carbolines; Convulsants; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1988 |
Consequences of chronic phenobarbital blockade of spontaneous motility in chick embryos for the development of central motor output activity.
Topics: Animals; Bicuculline; Central Nervous System; Chick Embryo; gamma-Aminobutyric Acid; Motor Activity; Oxazepam; Pentylenetetrazole; Phenobarbital; Strychnine | 1988 |
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Bicuculline; Body Temperature; Drug Interactions; Female; gamma-Aminobutyric Acid; Hypothermia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; Valproic Acid | 1985 |
Benzodiazepine-receptor mediated convulsions in infant rats: effects of beta-carbolines.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Flurazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors | 1986 |
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; Harmaline; Male; Mice; Mice, Inbred DBA; Ouabain; Papio; Pentylenetetrazole; Picrotoxin; Rats; Riluzole; Seizures; Synaptic Transmission; Thiazoles | 1985 |
Interactions of angiotensin II and GABA-ergic agents at the threshold of convulsive reactions.
Topics: Aminooxyacetic Acid; Angiotensin II; Animals; Anticonvulsants; Baclofen; Bicuculline; Brain; Drug Synergism; Male; Mice; Muscimol; Pentylenetetrazole; Receptors, GABA-A | 1986 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures | 1987 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Interactions; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1988 |
A comparison of prodrug esters of nipecotic acid.
Topics: Animals; Anticonvulsants; Bicuculline; Esters; GABA Antagonists; Male; Mice; Nipecotic Acids; Parasympathomimetics; Pentylenetetrazole; Pharmaceutical Preparations; Prodrugs; Proline; Seizures; Strychnine | 1988 |
Possible involvement of the central GABAergic system in pentobarbital-stimulated gastric acid secretion in the perfused rat stomach preparation.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Male; Pentobarbital; Pentylenetetrazole; Perfusion; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Anterior thalamic mediation of generalized pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Behavior, Animal; Bicuculline; Cerebral Cortex; Electroencephalography; Female; Guinea Pigs; Kainic Acid; Microinjections; Muscimol; Pentylenetetrazole; Seizures; Stereotaxic Techniques; Thalamic Nuclei; Vigabatrin | 1986 |
Differential convulsive susceptibility of high-activity and low-activity selected mice in response to GABA antagonists.
Topics: Animals; Behavior, Animal; Bicuculline; Female; Flurothyl; GABA Antagonists; Male; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1987 |
GABAergic drugs can enhance or attenuate chlordiazepoxide-induced sleep time in a heterogeneous strain of mice.
Topics: Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Chlordiazepoxide; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Picrotoxin; Sleep | 1986 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; Epilepsy; Kainic Acid; Methionine Sulfoximine; Pentylenetetrazole; Pyridoxine; Rabbits; Seizures | 1986 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures; Valproic Acid | 1985 |
Spiro[4.5] and spiro[4.6] carboxylic acids: cyclic analogues of valproic acid. Synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Bicuculline; Carboxylic Acids; Male; Mice; Pentylenetetrazole; Picrotoxin; Spiro Compounds; Structure-Activity Relationship; Valproic Acid | 1985 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Hypnotics and Sedatives; Kindling, Neurologic; Male; Mice; Motor Skills; Papio; Pentylenetetrazole; Photic Stimulation; Pyridazines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1986 |
Selective central nervous system calcium channel blockers--a new class of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channel Blockers; Central Nervous System; Convulsants; Drug Evaluation, Preclinical; Electroencephalography; Ischemia; Nicotinic Acids; Nimodipine; Pentylenetetrazole; Perfusion; Rabbits; Seizures; Verapamil | 1986 |
Changes in local cerebral glucose utilization induced by convulsants.
Topics: Animals; Bicuculline; Brain; Convulsants; Glucose; Male; Penicillins; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Soman; Strychnine | 1985 |
Antiepileptic drugs: detection, quantification, and evaluation.
Topics: Age Factors; Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1985 |
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Haloperidol; Lithium; Male; Mice; Pentylenetetrazole; Picrotoxin | 1985 |
Studies on the post-ictal rise in seizure threshold.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Electroshock; GABA Antagonists; Halothane; Lidocaine; Male; Maximum Allowable Concentration; Neurotransmitter Agents; Pentylenetetrazole; Propranolol; Prostaglandins; Rats; Seizures | 1981 |
Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Drinking Behavior; Drug Interactions; Ethanol; Exploratory Behavior; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Sleep | 1982 |
Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Chlordiazepoxide; Clonazepam; Dose-Response Relationship, Drug; Male; Muridae; Nitrazepam; Pentylenetetrazole; Phenytoin; Seizures | 1982 |
[Effects of pentylenetetrazol on conflict behavior and interactions with anxiolytics in rats].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains | 1983 |
Intracranial pressure during prolonged experimental convulsions in cats.
Topics: Animals; Bicuculline; Blood Pressure; Cats; Intracranial Pressure; Pentylenetetrazole; Seizures | 1983 |
Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Ceruletide; Cholecystokinin; Diazepam; Kinetics; Male; Mice; Pentylenetetrazole; Seizures; Sincalide; Strychnine; Time Factors | 1980 |
Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).
Topics: Animals; Bicuculline; Electroshock; GABA Antagonists; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures | 1982 |
Classification of some GABA antagonists with regard to site of action and potency in slices of rat cuneate nucleus.
Topics: Animals; Bicuculline; Cyclic P-Oxides; Furosemide; GABA Antagonists; In Vitro Techniques; Medulla Oblongata; Organophosphorus Compounds; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Strychnine; Tubocurarine | 1982 |
The effects of pentylenetetrazol, bicuculline and strychnine on the development of kindled seizures.
Topics: Animals; Bicuculline; Electroencephalography; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.
Topics: Animals; Behavior, Animal; Bicuculline; Body Temperature Regulation; Dose-Response Relationship, Drug; Ethanol; Female; Motor Activity; Muridae; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Sleep Stages; Strychnine | 1982 |
Generalization between benzodiazepine- and triazolopyridazine-elicited discriminative cues.
Topics: Amphetamine; Animals; Benzodiazepines; Bicuculline; Chlordiazepoxide; Discrimination Learning; Drug Antagonism; Male; Pentylenetetrazole; Pyridazines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Reinforcement, Psychology; Strychnine | 1982 |
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice.
Topics: 3-Mercaptopropionic Acid; 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Brain; Convulsants; Humans; Mice; Morphine Dependence; Pentylenetetrazole; Receptors, Opioid; Seizures; Strychnine | 1983 |
Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cyclooxygenase Inhibitors; Electroshock; Female; Hindlimb; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Female; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Papio; Pentylenetetrazole; Photic Stimulation; Seizures; Strychnine; Valproic Acid | 1984 |
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Drug Synergism; Ethanolamines; Glycine; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Sesterterpenes; Strychnine; Vigabatrin | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Convulsant-induced depression of amino acid responses in cultured mouse spinal neurones studied under voltage clamp.
Topics: Amino Acids; Animals; Bicuculline; Cells, Cultured; Convulsants; GABA Antagonists; Glycine; Membrane Potentials; Mice; Neurons; Pentylenetetrazole; Picrotoxin; Spinal Cord; Strychnine | 1983 |
Anticonvulsant activity of milacemide.
Topics: Acetamides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1983 |
Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice.
Topics: Animals; Bicuculline; Brain; Brain Chemistry; Electroshock; Female; Malonates; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenobarbital; Phenylethylmalonamide; Primidone; Seizures | 1983 |
Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds.
Topics: Animals; Bicuculline; Injections, Intraventricular; Isomerism; Kynurenine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1984 |
Anticonvulsant activity of some 4-aminobenzamides.
Topics: Animals; Anticonvulsants; Benzamides; Bicuculline; Electroshock; Male; Mice; Pentylenetetrazole; Seizures | 1984 |
Specific gravity increases and brain water content decreases during short epileptiform seizures in discrete rabbit brain areas.
Topics: Animals; Bicuculline; Blood; Blood-Brain Barrier; Body Water; Brain; Epilepsy; Epinephrine; Hypertension; Male; Pentylenetetrazole; Rabbits; Specific Gravity; Time Factors; Tissue Distribution | 1984 |
[Tranquilizing effect of n-dipropylacetate and other GABA-ergic substances in conflict situations].
Topics: Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Caffeine; Conflict, Psychological; Male; Models, Psychological; Pantothenic Acid; Pentylenetetrazole; Piracetam; Pyrrolidinones; Rats; Tranquilizing Agents; Valproic Acid | 1980 |
Repeated administration of subconvulsant doses of GABA antagonist drugs. II. Effect on monoamine-mediated behaviour.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; GABA Antagonists; Humans; Kindling, Neurologic; Male; Methamphetamine; Motor Activity; Pentylenetetrazole; Picrotoxin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Stereotyped Behavior | 1982 |
[Comparison of the anticonvulsant and central effects of 3-bromophenylsuccinimide and N-methylimide of 3,5-dibromophenylsuccinic acid].
Topics: Animals; Anticonvulsants; Bicuculline; Bromosuccinimide; Depression, Chemical; Female; Humans; Hypnotics and Sedatives; Mice; Motor Activity; Pentylenetetrazole; Seizures; Stereotyped Behavior; Succinimides | 1982 |
Antagonism of gamma-aminobutyric acid and muscimol by picrotoxin, bicuculline, strychnine, bemegride, leptazol, D-tubocurarine and theophylline in the isolated olfactory cortex.
Topics: Animals; Bicuculline; GABA Antagonists; Guinea Pigs; In Vitro Techniques; Muscimol; Olfactory Bulb; Oxazoles; Pentylenetetrazole; Picrotoxin; Strychnine; Theophylline; Tubocurarine | 1982 |
Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Seizures; Substantia Nigra | 1982 |
Effect of trimethyltin on chemically-induced seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Isoniazid; Male; Mice; Pentylenetetrazole; Seizures; Strychnine; Time Factors; Trialkyltin Compounds; Trimethyltin Compounds | 1982 |
Esters of nipecotic and isonipecotic acids as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Chemistry, Physical; Isonipecotic Acids; Mice; Nipecotic Acids; Pentylenetetrazole | 1982 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures | 1981 |
Alterations in local glucose consumption following systemic administration of kainic acid, bicuculline or metrazol.
Topics: Animals; Bicuculline; Brain; Convulsants; Deoxyglucose; Glucose; Kainic Acid; Male; Pentylenetetrazole; Pyrrolidines; Rats | 1981 |
Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy.
Topics: Animals; Bicuculline; Brain; Deoxy Sugars; Deoxyglucose; Electric Conductivity; Glucose; Kainic Acid; Male; Organ Specificity; Pentylenetetrazole; Pyrrolidines; Rats; Seizures | 1981 |
Muscimol and gamma-hydroxybutyrate: similar interactions with convulsant agents.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Hydroxybutyrates; Male; Mice; Muscimol; Oxazoles; Pentylenetetrazole; Seizures; Sodium Oxybate; Strychnine; Sulfhydryl Compounds | 1981 |
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrrolidines; Seizures | 1980 |
On the measurement in rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock.
Topics: Animals; Bicuculline; Convulsants; Electroshock; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intravenous; Male; Pentylenetetrazole; Rats; Seizures | 1980 |
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Cerebrovascular Circulation; Enzyme Inhibitors; Indazoles; Kainic Acid; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide and prototype antiepileptic drugs in mice and rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Rats, Sprague-Dawley; Seizures; Strychnine | 1995 |
Prenatal cocaine: seizure susceptibility in rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Body Weight; Brain; Cocaine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pentylenetetrazole; Pregnancy; Rats; Rats, Wistar; Seizures | 1995 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Purinergic P1; Seizures; Sex Factors; Strychnine | 1995 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Imidazoles; Isoniazid; Male; Mice; Pentylenetetrazole; Pyridines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Pentylenetetrazole; Seizures | 1994 |
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1994 |
Kainic acid, bicuculline, pentylenetetrazol and pilocarpine elicit maximal dentate activation in the anesthetized rat.
Topics: Anesthesia; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley | 1994 |
Experimental seizures in the frog (Rana pipiens).
Topics: Animals; Behavior, Animal; Bicuculline; Brain; Cisplatin; Convulsants; Electroencephalography; Kainic Acid; Pentylenetetrazole; Rana pipiens; Seizures; Strychnine | 1994 |
Synthesis and anticonvulsant activity of 1,3-dihydro-5-phenyl-2H-pyrido[3,2-e]-1,4-diazepin-2-ones.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Evaluation, Preclinical; Mice; Pentylenetetrazole; Pyridones; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 1993 |
GABA-responses of CA3 neurones at epileptogenic threshold concentrations of convulsants.
Topics: Action Potentials; Animals; Bicarbonates; Bicuculline; Caffeine; Chlorides; Convulsants; Epilepsy; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Penicillins; Pentylenetetrazole; Synapses | 1993 |
Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents.
Topics: Animals; Anti-Infective Agents; Behavior, Animal; Bicuculline; Body Temperature; Central Nervous System; Drug Interactions; Female; Fluoroquinolones; Male; Mice; Motor Activity; Naphthyridines; Pentylenetetrazole; Phenylbutyrates; Postural Balance; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
The comparison of anticonvulsant properties of commercial diphenylhydantoin (DPH) and its 3-amino-derivative (3-amino-DPH).
Topics: Administration, Oral; Animals; Anticonvulsants; Bicuculline; Injections, Intraperitoneal; Lethal Dose 50; Mice; Pentylenetetrazole; Phenytoin; Psychomotor Performance; Strychnine | 1993 |
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamates; Dyskinesia, Drug-Induced; Electroshock; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Phenylenediamines; Postural Balance; Rats; Rats, Wistar; Seizures; Strychnine | 1996 |
Indispensable amino acid deficiency and increased seizure susceptibility in rats.
Topics: Amino Acids; Animals; Bicuculline; Differential Threshold; Disease Susceptibility; Drug Administration Schedule; Histidine; Injections; Injections, Intraperitoneal; Isoleucine; Limbic System; Male; Olfactory Pathways; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Threonine | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diazepam; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Quinazolines; Rats; Rats, Wistar; Seizures | 1996 |
Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice.
Topics: Animals; Arginine; Bicuculline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Time Factors | 1996 |
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
Topics: Animals; Bicuculline; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Protein-Tyrosine Kinases; Seizures | 1996 |
Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding.
Topics: Animals; Autoradiography; Behavior, Animal; Bicuculline; Brain; Caffeine; Disease Susceptibility; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Receptors, GABA-A; Receptors, Purinergic P1; RNA, Messenger; Seizures; Time Factors; Xanthines | 1996 |
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
Topics: Anesthesia; Animals; Anticonvulsants; Bicuculline; Calcium; Cerebellum; Electroshock; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Piperidines; Potassium; Pyrroles; Rats; Seizures; Structure-Activity Relationship; Veratridine | 1997 |
Preliminary evaluation of the anticonvulsant activity of a valproic acid analog: N-(2-propylpentanoyl) urea.
Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System; Convulsants; Dose-Response Relationship, Drug; Electroshock; Lethal Dose 50; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Sleep; Strychnine; Time Factors; Urea; Valproic Acid | 1997 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Efficacy of shitei-to, a traditional Chinese medicine formulation, against convulsions in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Drugs, Chinese Herbal; Electroshock; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Strychnine | 1999 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamates; Humans; Kynurenic Acid; Lidocaine; Limbic System; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Solitary Nucleus; Synaptic Transmission; Vagus Nerve | 1999 |
Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Chemotactic Factors; Convulsants; Dithionitrobenzoic Acid; Epilepsy; Hippocampus; Indicators and Reagents; Long-Term Potentiation; Membrane Potentials; Oxidation-Reduction; Patch-Clamp Techniques; Pentylenetetrazole; Phosphines; PQQ Cofactor; Quinolones; Quinones; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Seizures; Sulfhydryl Reagents | 2000 |
Seizures and neuronal damage in mice lacking vesicular zinc.
Topics: Animals; Bicuculline; Carrier Proteins; Cation Transport Proteins; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Flurothyl; Genetic Predisposition to Disease; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Metallothionein 3; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Seizures; Synapses; Synaptic Vesicles; Zinc | 2000 |
Design and synthesis of anticonvulsive agents as gamma-vinyl GABA-based potential dual acting prodrugs and their biological activities.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Design; Mice; Pentylenetetrazole; Picrotoxin; Prodrugs; Seizures; Vigabatrin | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Guanosine; Hippocampus; Hypoxanthine; Inosine; Kainic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Xanthine | 2000 |
Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Generalized; Magnoliopsida; Male; Mice; Muscle Contraction; Pentylenetetrazole; Picrotoxin; Plant Extracts; Plant Roots; Plants, Medicinal | 2001 |
Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electroshock; Ethanol; Male; Mice; Pentylenetetrazole; Picrotoxin; Ranunculaceae; Solvents; Strychnine; Water | 2001 |
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Drug Resistance; Electroencephalography; Excitatory Amino Acid Agonists; Gene Targeting; Genetic Predisposition to Disease; Glycine; Hippocampus; Homozygote; In Vitro Techniques; Mice; Mice, Knockout; Pentylenetetrazole; Phenotype; Physical Chromosome Mapping; Receptors, Metabotropic Glutamate; Seizures | 2001 |
Nociceptin, OP4 receptor ligand in different models of experimental epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Epilepsy; Female; Mice; N-Methylaspartate; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pentylenetetrazole; Receptors, Opioid | 2002 |
Selectivity of the protective effects of dihydropyridine calcium channel antagonists against the ethanol withdrawal syndrome.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Bicuculline; Body Temperature; Calcium Channel Blockers; Central Nervous System Depressants; Convulsants; Dihydropyridines; Ethanol; GABA Antagonists; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome | 2002 |
Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug.
Topics: Acoustic Stimulation; Administration, Oral; Amides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Cyclopropanes; Electrophysiology; Electroshock; Epilepsy; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Mutagenicity Tests; Neural Tube Defects; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 2002 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flurazepam; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mesocricetus; Microinjections; Muscimol; Pentylenetetrazole; Phenobarbital | 2002 |
Anticonvulsant activity of aqueous extract of Leonotis leonurus.
Topics: Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Lamiaceae; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2002 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Genotype; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Potassium Channel Blockers; Receptors, GABA-A; Receptors, Nicotinic; Seizures; Strychnine | 2002 |
Effects of GABA(A) compounds on mCPP drug discrimination in rats.
Topics: Alprazolam; Animals; Azides; Benzodiazepines; Bicuculline; Conditioning, Operant; Discrimination, Psychological; Flumazenil; GABA Agonists; GABA Antagonists; Male; Pentylenetetrazole; Piperazines; Rats; Rats, Long-Evans; Receptors, GABA-A | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental | 2002 |
In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cells, Cultured; Delphinium; Epilepsy; GABA Antagonists; Patch-Clamp Techniques; Pentylenetetrazole; Plant Extracts; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2002 |
Differential sensitivity of genetically Fast vs. Slow kindling rats strains to GABAergic convulsive agents.
Topics: Animals; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine Agents; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Long-Evans; Rats, Wistar; Species Specificity; Strychnine | 2003 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; gamma-Aminobutyric Acid; Hippocampus; Isotopes; Ovariectomy; Pentylenetetrazole; Progestins; Rats; Rats, Long-Evans; Reaction Time; Receptors, GABA-A; Seizures; Tissue Distribution | 2005 |
GABAergic modulation of the discriminative stimulus effects of methamphetamine.
Topics: Animals; Bicuculline; Central Nervous System Stimulants; Chlordiazepoxide; Discrimination Learning; Discrimination, Psychological; Drug Interactions; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Methamphetamine; Pentobarbital; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2005 |
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Topics: Animals; Antiporters; Bicuculline; Brain; Chloride-Bicarbonate Antiporters; Convulsants; Dentate Gyrus; Gene Targeting; Hydrogen-Ion Concentration; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; Seizures; Sensory Thresholds | 2006 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Pain; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Tetrapleura | 2005 |
The proconvulsant effect of sildenafil in mice: role of nitric oxide-cGMP pathway.
Topics: Animals; Arginine; Bicuculline; Cyclic GMP; Dose-Response Relationship, Drug; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pentylenetetrazole; Phosphodiesterase Inhibitors; Piperazines; Purines; Seizures; Signal Transduction; Sildenafil Citrate; Sulfones | 2006 |
Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Hesperidin; Hippocampus; In Vitro Techniques; Male; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tetraethylammonium | 2006 |
Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Persea; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2006 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behavior; Diazepam; Disease Models, Animal; Drug Interactions; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Spider Venoms; Spiders; Substantia Nigra; Urea | 2006 |
Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Crassulaceae; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2007 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epilepsy, Reflex; Excitatory Amino Acid Agonists; GABA Antagonists; Homocysteine; Kindling, Neurologic; Lacosamide; Male; Mice; N-Methylaspartate; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Disease Susceptibility; Drug Interactions; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Severity of Illness Index | 2007 |
Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Hypoxis; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Effect of classic convulsants on Cl- conductance of the GABA(A) receptor complex in membranes of cerebral cortex cells at the early stage of kindling.
Topics: Animals; Bicuculline; Cerebral Cortex; Chloride Channels; Convulsants; Drug Synergism; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Membranes; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2007 |
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Mice; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Anticonvulsant effect of Rhus chirindensis (Baker F.) (Anacardiaceae) stem-bark aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Rhus | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 2008 |
Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Generalized; Lethal Dose 50; Male; Methanol; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plant Extracts; Plant Leaves; Polygalaceae; Seizures; Solvents; Water | 2008 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Cerebellar Purkinje cells fire paroxysmal depolarization shift (PDS)-like events in response to epileptogenic drugs.
Topics: 4-Aminopyridine; Action Potentials; Animals; Bicuculline; Cerebellum; Convulsants; Male; Pentylenetetrazole; Purkinje Cells; Rats; Rats, Sprague-Dawley | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Flowers; Heterocyclic Compounds, 4 or More Rings; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Seizures | 2011 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pentylenetetrazole; Pyrimidinones; Seizures; Semicarbazides; Structure-Activity Relationship; Triazoles | 2011 |
Anticonvulsant action of indazole.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Indazoles; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures; Strychnine | 2013 |
Normotopic cortex is the major contributor to epilepsy in experimental double cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Classical Lissencephalies and Subcortical Band Heterotopias; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electroencephalography; Electrophysiological Phenomena; Epilepsy; Gene Knockdown Techniques; Microtubule-Associated Proteins; Neocortex; Nerve Net; Neuropeptides; Pentylenetetrazole; Rats; Rats, Transgenic; Seizures; Somatosensory Cortex | 2014 |
GABAB, not GABAA receptors play a role in cortical postictal refractoriness.
Topics: Animals; Azepines; Bicuculline; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Epilepsy; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Pentylenetetrazole; Picrotoxin; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B | 2015 |
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Quinazolinones; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Time Factors; Triazoles | 2015 |
The activity of selective sigma-1 receptor ligands in seizure models in vivo.
Topics: Acetamides; Analysis of Variance; Animals; Anisoles; Anticonvulsants; Bicuculline; Convulsants; Male; Mice; Morpholines; Pentylenetetrazole; Propylamines; Pyrrolidinones; Receptors, sigma; Seizures; Sigma-1 Receptor; Survival Analysis | 2017 |
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electric Stimulation; Flumazenil; Male; Mice; Pentylenetetrazole; Pilocarpine; Plant Extracts; Plant Leaves; Plants, Medicinal; Random Allocation; Seizures; Senna Plant | 2018 |
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures.
Topics: Animals; Anisoles; Bicuculline; Convulsants; Gene Expression; Genetic Predisposition to Disease; Habenula; Hippocampus; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Pentylenetetrazole; Propylamines; Receptors, GABA-A; Receptors, GABA-B; Receptors, sigma; Seizures; Sigma-1 Receptor | 2021 |
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Mice; Muscarinic Agonists; Pentylenetetrazole; Phenols; Pilocarpine; Propofol; Rats; Receptors, GABA-A; Seizures; Status Epilepticus | 2021 |