pentoxyl has been researched along with 5-hydroxymethyluracil in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (19.38) | 18.7374 |
| 1990's | 40 (31.01) | 18.2507 |
| 2000's | 20 (15.50) | 29.6817 |
| 2010's | 38 (29.46) | 24.3611 |
| 2020's | 6 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Hayatsu, H; Shiragami, M | 1 |
| Rae, PM; Steele, RE | 1 |
| Rae, PM | 1 |
| Duker, NJ; Ganguly, T | 2 |
| Cocito, CG; Coene, MM; Hoet, PP | 1 |
| Chen, XW; Djuric, Z; Duffy, PH; Hart, RW; Heilbrun, LK; Lewis, SM; Lu, MH; Luongo, DA; Reading, BA | 1 |
| Djuric, Z; Potter, DW | 1 |
| Levy, DD; Teebor, GW | 1 |
| Härd, T; Kearns, DR | 1 |
| Cannon-Carlson, SV; Gokhale, H; Teebor, GW | 1 |
| Herrala, AM; Vilpo, JA | 1 |
| Kaufman, ER | 1 |
| Boorstein, RJ; Cannon, SV; Teebor, GW | 1 |
| Giese, RW; Itani, M; Kresbach, GM; Rogers, EJ; Saha, M; Vouros, P | 1 |
| Boorstein, RJ; Teebor, GW | 2 |
| Choy, HA; Geiduschek, EP; Romeo, JM | 1 |
| Boorstein, RJ; Levy, DD; Teebor, GW | 1 |
| Geiduschek, EP; Greene, JR; Morrissey, LM | 1 |
| Cadet, J; Cummings, A; Frenkel, K; Solomon, J; Steinberg, JJ; Teebor, GW | 1 |
| Bron, S; Luxen, E; Venema, G | 1 |
| Hannett, NM; Korman, A; Lee, G; Pero, J | 1 |
| Beemer, FA; Berger, R; de Bree, PK; Duran, M; Penders, TJ; Stoker-de Vries, SA; van der Woude, JK; Wadman, SK; Weits-Binnerts, JJ | 1 |
| Abbott, MT; Macrander, LA; Warn-Cramer, BJ | 1 |
| Kraal, I; Leyva, A; Pinedo, HM; Schornagel, JH; Wadman, SK | 1 |
| Curran, JF; Stewart, CR | 1 |
| Daney de Marcillac, G; Herzog, M; Soyer, MO | 1 |
| Warren, RA | 1 |
| Bjelland, S; Eftedal, I; Eide, L; Seeberg, E; Stote, R; Time, RW; Volden, G | 1 |
| Miller, SL; Robertson, MP | 1 |
| Castro, GD; Castro, JA; Stamato, CJ | 1 |
| Vilpo, JA; Vilpo, LM | 1 |
| Djuric, Z; Hart, RW; Heilbrun, LK; Martino, S | 1 |
| Boujet, C; Cadet, J; Ducros, V; Faure, H; Favier, A; Incardona, MF | 1 |
| Borst, P; Gommers-Ampt, JH; Teixeira, AJ; van de Werken, G; van Dijk, WJ | 1 |
| Fujimoto, J; Yonei, S; Zhang, QM | 1 |
| Goodrich-Blair, H; Shub, DA | 1 |
| Bianchini, F; Cadet, J; Coudray, C; Douki, T; Ducros, V; Faure, H; Favier, A; Mousseau, M | 1 |
| Galeone, A; Geiduschek, EP; Grove, A; Mayol, L | 1 |
| Mazurek, M; Sowers, LC | 1 |
| Castro, GD; Castro, JA; Díaz Gómez, MI | 1 |
| Figueiredo, ML; Galeone, A; Geiduschek, EP; Grove, A; Mayol, L | 1 |
| Ambulos, NP; Friedberg, EC; Malanoski, G; Radany, EH; Yasbin, RE | 2 |
| Aruoma, OI; England, TG; Halliwell, B; Jenner, A | 2 |
| Depper, JB; Djuric, Z; Heilbrun, LK; Lababidi, S; Martino, S; Smith, D; Uhley, V | 1 |
| LaFrancois, CJ; Sowers, LC; Yu, K | 1 |
| Cadet, J; Faure, H; Favier, A; Guimier, C; Hida, H; Mousseau, M; Tripier, M | 1 |
| Cezanne, I; Christensen, E; Faurholt Pedersen, V; Hørlyk, H; Kjaergaard, S; Van Gennip, AH; van Kuilenburg, AB; Vreken, P | 1 |
| Borst, P; Cross, M; Kieft, R; van Leeuwen, F | 1 |
| Galeone, A; Geiduschek, EP; Grove, A; Mayol, L; Yu, E | 1 |
| Dilman, V; Durr, NP; Frenkel, K; Karkoszka, J; Kato, I; Orentreich, N; Toniolo, P; Vogelman, JH | 1 |
| Kino, K; Matsuda, S; Miyabe, I; Saito, I; Sugiyama, H; Yonei, S; Zhang, QM | 1 |
| Dizdaroglu, M | 1 |
| Honsho, A; Ide, H; Kobayashi, M; Masaoka, A; Ohyama, Y; Terato, H | 1 |
| Dizdaroglu, M; Sentürker, S | 1 |
| Cadet, J; Guicherd, P; Ravanat, JL; Tuce, Z | 1 |
| Kearns, DR; Mayol, L; Pepe, A; Vu, HM | 1 |
| Cadet, J; Ducros, V; Faure, H; Favier, A; Firoozi, F; Hee, J; Pourcelot, S; Tripier, M | 1 |
| Boorstein, RJ; Brandon, ML; Chaung, W; Mi, L; Teebor, G | 1 |
| Kearns, DR; Pasternack, LB; Vu, HM | 1 |
| Rusmintratip, V; Sowers, LC | 1 |
| Boorstein, RJ; Chaung, W; Horowitz, R; Mi, LJ; Teebor, GW | 1 |
| Grove, A; Lim, L | 1 |
| Boorstein, RJ; Brown, SM; Chan, MK; Cummings, A; Ma, Y; Marenstein, DR; Neubert, TA; Teebor, GW | 1 |
| Schwartz, AW | 1 |
| Grove, A; Saavedra, TC | 1 |
| Burdzy, A; Lin, SS; Liu, P; Rogstad, DK; Sowers, LC | 1 |
| Kow, YW | 1 |
| Hori, M; Kino, K; Sugiyama, H; Yamamoto, K; Yonei, S; Zhang, QM | 1 |
| Haushalter, K; Pearl, LH; Verdine, GL; Waters, TR; Wibley, JE | 1 |
| Izuta, S; Kasama, T; Ono, A | 1 |
| Grove, A | 1 |
| KALLEN, RG; MARMUR, J; SIMON, M | 1 |
| ABBOTT, MT; FINK, RM; KADNER, RJ | 1 |
| Akamatsu, K; Fujii, K; Yokoya, A | 1 |
| Ide, H; Izumi, S; Katayanagi, K; Matsubara, M; Ohmae, E; Tanaka, T; Terato, H | 1 |
| Sugiyama, H; Takao, M; Yasui, A; Yonei, S; Yonekura, S; Zhang, QM | 1 |
| Foksinski, M; Gackowski, D; Gran, C; Klungland, A; Olinski, R; Rozalski, R; Siomek, A | 1 |
| Chen, HJ; Huang, JL; Wu, CF | 1 |
| Asagoshi, K; Braithwaite, EK; Horton, JK; Kedar, PS; Lan, L; Miller, H; Polosina, YY; Poltoratsky, VP; Teebor, GW; Wilson, SH; Yasui, A | 1 |
| Mirsaev, TR | 2 |
| Mananova, SSh; Pashnina, IA; Sibiryak, SV | 1 |
| Chang, Y; Cheng, X; Hashimoto, H; Howerton, SB; Liu, Y; Upadhyay, AK; Vertino, PM; Zhang, X | 1 |
| Dingler, FA; Kemmerich, K; Neuberger, MS; Rada, C | 1 |
| Agrawal, B; Bhavanam, S; Desroches, N; Kumar, R; Kunimoto, DY; Shakya, N; Srivastav, NC; Tse, C | 1 |
| Cheng, X; Hashimoto, H; Zhang, X | 1 |
| Couvé, S; Grin, I; Henriot, V; Ishchenko, AA; Moréra, S; Saparbaev, M; Vigouroux, A | 1 |
| Bhagwat, AS; Cheng, X; Hashimoto, H; Hong, S; Zhang, X | 1 |
| Aveiro, F; Câmara, JS; Mendes, B; Pereira, J; Silva, P | 1 |
| Madugundu, GS; Park, Y; Peoples, AR; Sanche, L; Wagner, JR | 1 |
| Foksinski, M; Gackowski, D; Olinski, R; Zarakowska, E | 1 |
| Câmara, JS; Mendes, B; Mendonça, I; Pereira, J; Silva, P | 1 |
| Çırak, Ç; Sert, Y; Ucun, F | 1 |
| Brandmayr, C; Carell, T; Eisen, D; Hackner, B; Kashiwazaki, G; Kosmatchev, O; Kotljarova, O; Laube, SK; Leonhardt, H; Michalakis, S; Müller, M; Müller, U; Pfaffeneder, T; Raddaoui, N; Schär, P; Schiesser, S; Schuermann, D; Spada, F; Spruijt, CG; Steigenberger, B; Steinbacher, J; Truss, M; Vermeulen, M; Wagner, M | 1 |
| Hocek, M; Vaníková, Z | 1 |
| Bullard, W; Liu, S; Lopes da Rosa-Spiegler, J; Sabatini, R; Wang, Y | 1 |
| Dahl, JA; Klungland, A; Robertson, AB | 1 |
| Gainullina, YY; Gus'kov, VY; Ivanov, SP; Kudasheva, FKh | 1 |
| Darwanto, A; Hsu, CW; Sowers, LC; Theruvathu, JA | 1 |
| Foksinski, M; Gackowski, D; Guz, J; Olinski, R; Rozalski, R | 1 |
| Ganguly, B; Jana, K | 1 |
| He, C; Song, CX; Yu, M | 1 |
| Balasubramanian, S; Hardisty, RE; Kawasaki, F; Sahakyan, AB | 1 |
| Banaszkiewicz, Z; Gackowski, D; Modrzejewska, M; Olinski, R; Rozalski, R; Siomek-Gorecka, A; Starczak, M | 1 |
| Coey, CT; Drohat, AC; Malik, SS; Pozharski, E; Varney, KM | 1 |
| Ding, J; Li, W; Zhang, T | 1 |
| Aksimentiev, A; Carson, S; Wanunu, M; Weigele, PR; Wilson, J | 1 |
| Gackowski, D; Modrzejewska, M; Olinski, R; Starczak, M; Zarakowska, E | 1 |
| Bullard, W; Cliffe, L; Sabatini, R; Wang, P; Wang, Y | 1 |
| Grin, I; Ishchenko, AA | 1 |
| Callahan, MP; Dworkin, JP; House, CH; Smith, KE | 1 |
| Bolte, M; Hützler, WM; Seiler, VK | 1 |
| Foksinski, M; Gackowski, D; Gawronski, M; Modrzejewska, M; Olinski, R; Rzeszowska-Wolny, J; Skonieczna, M; Starczak, M; Zarakowska, E | 1 |
| Balasubramanian, S; Beraldi, D; Hardisty, RE; Kawasaki, F; McInroy, GR; van Delft, P | 1 |
| Boháčová, S; Hocek, M; Janoušková, M; Krásný, L; Nici, F; Šanderová, H; Vaníková, Z; Vítovská, D | 1 |
| Bednárová, K; Dvoráková, Z; Kejnovská, I; Renciuk, D; Sagi, J; Školáková, P; Vorlícková, M | 1 |
| Boháčová, S; Hocek, M; Klán, P; Ludvíková, L; Poštová Slavětínská, L; Vaníková, Z | 1 |
| Papaluca, A; Ramotar, D; Saragovi, HU; Wagner, JR | 1 |
| Abakir, A; Gackowski, D; Gawronski, M; Kerr, C; Maciejewski, JP; Olinski, R; Radivoyevitch, T; Ruzov, A; Starczak, M; Zarakowska, E | 1 |
| Brabec, V; Hrabina, O; Novakova, O | 1 |
| Bai, M; Chen, F; Fan, C; Xue, J; Yu, X; Zhang, J; Zhao, Y | 1 |
| Abakir, A; Ruzov, A | 1 |
| Gackowska, L; Gackowski, D; Labejszo, A | 1 |
| Abduh, NAY; Afzal, M; Alarifi, A; Ayub, R; Fatima, A; Jaiswar, G; Javed, S; Kumar, M; Muddassir, M; Saeed, WS; Siddiqui, N | 1 |
| Cai, Y; Jiang, S; Liu, Q; Wang, ZY; Zhang, CY; Zhang, QY | 1 |
5 review(s) available for pentoxyl and 5-hydroxymethyluracil
| Article | Year |
|---|---|
Replication cycle of Bacillus subtilis hydroxymethyluracil-containing phages.
Topics: Bacillus Phages; Bacillus subtilis; Base Sequence; Molecular Sequence Data; Pentoxyl; Virus Replication | 1992 |
Modified bases in bacteriophage DNAs.
Topics: 2-Aminopurine; 5-Methylcytosine; Adenine; Bacteriophages; Base Composition; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytosine; Deoxyribonucleases; DNA Replication; DNA, Viral; Nucleic Acid Conformation; Pentoxyl; Substrate Specificity; Templates, Genetic; Thymine; Transcription, Genetic; Uracil | 1980 |
Facts about the artifacts in the measurement of oxidative DNA base damage by gas chromatography-mass spectrometry.
Topics: Adenine; Animals; Artifacts; Base Pairing; Cattle; Cytosine; DNA; DNA Damage; DNA Repair; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Oxidation-Reduction; Oxidative Stress; Pentoxyl; Pyrimidines; Temperature; Thymus Gland | 1998 |
Repair of deaminated bases in DNA.
Topics: Animals; Base Pair Mismatch; DNA; DNA Repair; Humans; Pentoxyl; Purines; Pyrimidines; Uracil | 2002 |
Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?
Topics: Animals; Brain; Cell Nucleus; Chromatin; Cytidine Deaminase; DNA; DNA Damage; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation; Genetic Markers; Guanine; Liver; Mixed Function Oxygenases; Oxidation-Reduction; Pentoxyl; Proto-Oncogene Proteins; Swine; Thymine; Thymus Gland | 2014 |
3 trial(s) available for pentoxyl and 5-hydroxymethyluracil
| Article | Year |
|---|---|
Dietary modulation of oxidative DNA damage.
Topics: Adolescent; Adult; Aged; Animals; Breast Neoplasms; Diet; Dietary Fats; DNA; DNA Damage; Energy Intake; Female; Humans; Liver; Mammary Glands, Animal; Middle Aged; Oxidation-Reduction; Pentoxyl; Rats; Rats, Inbred F344 | 1994 |
Oxidative DNA damage levels in blood from women at high risk for breast cancer are associated with dietary intakes of meats, vegetables, and fruits.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Diet; DNA; DNA Damage; Female; Fruit; Humans; Meat; Middle Aged; Oxidative Stress; Pentoxyl; Risk Factors; Vegetables | 1998 |
Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil.
Topics: Analysis of Variance; Antibody Formation; Confidence Intervals; Dietary Supplements; DNA Damage; Female; Humans; Immunoglobulin M; Iron Chelating Agents; Middle Aged; Obesity; Pentoxyl; Picolinic Acids; Prospective Studies | 1998 |
121 other study(ies) available for pentoxyl and 5-hydroxymethyluracil
| Article | Year |
|---|---|
Reaction of bisulfite with the 5-hydroxymethyl group in pyrimidines and in phage DNAs.
Topics: 5-Methylcytosine; Chemical Phenomena; Chemistry; Coliphages; Cytosine; DNA, Viral; Pentoxyl; Pyrimidines; Spectrophotometry, Ultraviolet; Sulfites; Uracil | 1979 |
Modified bases in the DNAs of unicellular eukaryotes: an examination of distributions and possible roles, with emphasis on hydroxymethyluracil in dinoflagellates.
Topics: Adenine; Animals; Cells; Cytosine; Dinoflagellida; DNA; Eukaryota; Eukaryotic Cells; Pentoxyl; Uracil | 1978 |
Hydroxymethyluracil in eukaryote DNA: a natural feature of the pyrrophyta (dinoflagellates).
Topics: Animals; Biological Evolution; Centrifugation, Isopycnic; Dinoflagellida; DNA; Eukaryota; Nucleic Acid Denaturation; Pentoxyl; Species Specificity; Uracil | 1976 |
Reduced 5-hydroxymethyluracil-DNA glycosylase activity in Werner's syndrome cells.
Topics: Aging; Cells, Cultured; DNA Glycosylases; DNA Repair; Humans; Infant; Matched-Pair Analysis; Middle Aged; N-Glycosyl Hydrolases; Pentoxyl; Werner Syndrome | 1992 |
Oxidative DNA damage levels in rats fed low-fat, high-fat, or calorie-restricted diets.
Topics: Animals; Dietary Fats; DNA Damage; Energy Intake; Female; Gas Chromatography-Mass Spectrometry; Liver; Mammary Glands, Animal; Oxidation-Reduction; Pentoxyl; Rats; Rats, Inbred F344 | 1992 |
Comparison of 8-hydroxydeoxyguanosine and 5-hydroxymethyluracil as products of oxidative DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cattle; Deoxyguanosine; DNA Damage; Edetic Acid; Free Radicals; Hydrogen Peroxide; In Vitro Techniques; Iron; Mannitol; Oxygen; Pentoxyl | 1991 |
Site directed substitution of 5-hydroxymethyluracil for thymine in replicating phi X-174am3 DNA via synthesis of 5-hydroxymethyl-2'-deoxyuridine-5'-triphosphate.
Topics: Bacteriophages; Base Sequence; Cloning, Molecular; Codon; Deoxyuracil Nucleotides; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Escherichia coli; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Pentoxyl; Spheroplasts; Thymine; Transfection | 1991 |
Reduced DNA flexibility in complexes with a type II DNA binding protein.
Topics: Bacteriophages; DNA-Binding Proteins; DNA, Viral; Ethidium; Fluorescence Polarization; Molecular Structure; Nucleic Acid Conformation; Pentoxyl; Viral Proteins | 1990 |
Glycosylases that excise modified DNA pyrimidines in young and senescent human WI-38 fibroblasts.
Topics: Cell Line; Cell Survival; DNA Glycosylases; DNA Repair; DNA Replication; Fibroblasts; Humans; N-Glycosyl Hydrolases; Pentoxyl; Uracil-DNA Glycosidase | 1990 |
Purification and characterization of 5-hydroxymethyluracil-DNA glycosylase from calf thymus. Its possible role in the maintenance of methylated cytosine residues.
Topics: Animals; Cattle; Cytosine; Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Hydrogen-Ion Concentration; Kinetics; Methylation; Molecular Weight; N-Glycosyl Hydrolases; Pentoxyl; Rats; Substrate Specificity; Thymus Gland; Uracil; Uracil-DNA Glycosidase | 1989 |
Template-primer activity of 5-(hydroxymethyl)uracil-containing DNA for prokaryotic and eukaryotic DNA and RNA polymerases.
Topics: Bacillus subtilis; Bacteriophages; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; DNA, Viral; Escherichia coli; Humans; Leukemia; Micrococcus; Pentoxyl; Templates, Genetic; Thymine; Transcription, Genetic; Tumor Cells, Cultured; Uracil | 1989 |
Induction of sister chromatid exchanges by the thymidine analog 5-hydroxymethyl-2'-deoxyuridine.
Topics: Animals; Benzamides; Cells, Cultured; DNA; Mutagens; Pentoxyl; Sister Chromatid Exchange; Thymidine | 1989 |
Enzymatic repair of oxidative DNA damage.
Topics: Animals; Cells, Cultured; Cricetinae; DNA Damage; DNA Repair; Mutation; Oxidation-Reduction; Pentoxyl; Thymidine | 1989 |
Ester and related derivatives of ring N-pentafluorobenzylated 5-hydroxymethyluracil. Hydrolytic stability, mass spectral properties, and trace detection by gas chromatography-electron-capture detection, gas chromatography-electron-capture negative ion mas
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Liquid; DNA Damage; Esters; Hydrolysis; Mass Spectrometry; Pentoxyl; Uracil | 1989 |
Effects of 5-hydroxymethyluracil and 3-aminobenzamide on the repair and toxicity of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Cricetinae; DNA; DNA Repair; HeLa Cells; Pentoxyl; Thymidine; Uracil | 1989 |
Activity of a phage-modified RNA polymerase at hybrid promoters. Effects of substituting thymine for hydroxymethyluracil in a phage SP01 middle promoter.
Topics: Bacillus subtilis; Bacteriophages; Binding Sites; DNA-Directed RNA Polymerases; Nucleic Acid Hybridization; Pentoxyl; Promoter Regions, Genetic; Recombination, Genetic; Thymine; Transcription, Genetic | 1986 |
Mutagenicity of 5-hydroxymethyl-2'-deoxyuridine to Chinese hamster cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Glycosylases; DNA Repair; Mutagenicity Tests; N-Glycosyl Hydrolases; Pentoxyl; Thymidine | 1988 |
Toxicity of 3-aminobenzamide to Chinese hamster cells containing 5-hydroxymethyluracil in their DNA.
Topics: Animals; Benzamides; Cells, Cultured; Cricetinae; DNA; DNA Repair; Pentoxyl; Poly Adenosine Diphosphate Ribose; Uracil | 1987 |
DNA binding by the bacteriophage SPO1-encoded type II DNA-binding protein, transcription factor 1. Site-specific binding requires 5-hydroxymethyluracil-containing DNA.
Topics: Binding Sites; DNA-Binding Proteins; DNA, Bacterial; Geobacillus stearothermophilus; Mathematics; Pentoxyl; Structure-Activity Relationship; Transcription Factors; Uracil | 1986 |
Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of gamma-irradiated cells.
Topics: Acetylation; Chromatography, High Pressure Liquid; DNA; DNA, Bacterial; DNA, Neoplasm; Escherichia coli; Gamma Rays; HeLa Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pentoxyl; Thymine; Uracil | 1985 |
Resistance of bacteriophage H1 to restriction and modification by Bacillus subtilis R.
Topics: Bacillus subtilis; Bacteriophages; Base Sequence; Cloning, Molecular; Dimethyl Sulfoxide; DNA-Cytosine Methylases; DNA, Viral; Hydrogen-Ion Concentration; Methyltransferases; Pentoxyl; Uracil | 1983 |
Transcription of cloned DNA from Bacillus subtilis phage SP01. Requirement for hydroxymethyluracil-containing DNA by phage-modified RNA polymerase.
Topics: Bacillus subtilis; Bacteriophage lambda; Bacteriophages; Base Sequence; Cloning, Molecular; DNA-Directed RNA Polymerases; DNA, Viral; Electrophoresis, Agar Gel; Nucleic Acid Hybridization; Operon; Pentoxyl; Transcription, Genetic | 1980 |
Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism.
Topics: Adolescent; Child; Child, Preschool; Chromatography, Thin Layer; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Leukocytes; Male; Mass Spectrometry; Oxidoreductases; Pentoxyl; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 1984 |
Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis.
Topics: Adenosine Triphosphate; Ascorbic Acid; Electrophoresis, Disc; Mitosporic Fungi; Mixed Function Oxygenases; Molecular Weight; Pentoxyl; Rhodotorula; Uracil | 1983 |
Clinical and biochemical studies of high-dose thymidine treatment in patients with solid tumors.
Topics: Aged; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasms; Pentoxyl; Purines; Pyrimidines; Thymidine | 1984 |
Recombination and expression of a cloned fragment of the DNA of Bacillus subtilis bacteriophage SP01.
Topics: Bacillus subtilis; Bacteriophages; Base Sequence; Cloning, Molecular; DNA, Recombinant; DNA, Viral; Gene Expression Regulation; Genes, Viral; Operon; Pentoxyl; Plasmids; Recombination, Genetic | 1982 |
A high level of thymine replacement by 5-hydroxymethyluracil in nuclear DNA of the primitive dinoflagellate Prorocentrum micans E.
Topics: Animals; Base Composition; Centrifugation, Density Gradient; Cytosine; Dinoflagellida; DNA; Guanine; Nucleic Acid Denaturation; Pentoxyl; Thymine; Uracil | 1982 |
Oxidation of thymine to 5-formyluracil in DNA: mechanisms of formation, structural implications, and base excision by human cell free extracts.
Topics: Base Composition; Cell Extracts; Chromatography, High Pressure Liquid; DNA; DNA Glycosylases; DNA Repair; Humans; Kinetics; Leukocytes, Mononuclear; Molecular Structure; Mutagenesis; N-Glycosyl Hydrolases; Oxidation-Reduction; Pentoxyl; Photolysis; Thymine; Ultraviolet Rays; Uracil; Vitamin K | 1995 |
Prebiotic synthesis of 5-substituted uracils: a bridge between the RNA world and the DNA-protein world.
Topics: Amino Acids; Models, Chemical; Pentoxyl; RNA, Catalytic; Uracil | 1995 |
5-methylcytosine attack by free radicals arising from bromotrichloromethane in a model system: structures of reaction products.
Topics: 5-Methylcytosine; Aerobiosis; Anaerobiosis; Bromotrichloromethane; Cytosine; DNA; Free Radicals; Gas Chromatography-Mass Spectrometry; Models, Chemical; Pentoxyl; Thymine | 1994 |
Restriction, methylation and ligation of 5-hydroxymethyluracil-containing DNA.
Topics: Bacillus Phages; DNA Damage; DNA Ligases; DNA Restriction Enzymes; DNA, Viral; Hydrolysis; Kinetics; Methylation; Methyltransferases; Oxidation-Reduction; Oxidative Stress; Pentoxyl; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Thymine; Viral Proteins | 1995 |
Gas chromatographic-mass spectrometric determination of 5-hydroxymethyluracil in human urine by stable isotope dilution.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Indicator Dilution Techniques; Organosilicon Compounds; Pentoxyl; Silicon | 1993 |
The identification of hydroxymethyluracil in DNA of Trypanosoma brucei.
Topics: Animals; Bacteriophages; Chromatography, Liquid; DNA, Protozoan; Gas Chromatography-Mass Spectrometry; Pentoxyl; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Trypanosoma brucei brucei; Trypanosomiasis | 1993 |
Enzymatic release of 5-formyluracil by mammalian liver extracts from DNA irradiated with ionizing radiation.
Topics: Animals; DNA; DNA Repair; Female; Liver; Mice; Mice, Inbred ICR; Pentoxyl; Rats; Tissue Extracts; Uracil | 1995 |
Beyond homing: competition between intron endonucleases confers a selective advantage on flanking genetic markers.
Topics: Bacillus Phages; Bacillus subtilis; Base Sequence; Cloning, Molecular; DNA Restriction Enzymes; DNA-Directed DNA Polymerase; DNA, Viral; Genetic Markers; Introns; Molecular Sequence Data; Open Reading Frames; Pentoxyl; Substrate Specificity | 1996 |
5-Hydroxymethyluracil excretion, plasma TBARS and plasma antioxidant vitamins in adriamycin-treated patients.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antioxidants; DNA Damage; Doxorubicin; Female; Humans; Male; Middle Aged; Neoplasms; Pentoxyl; Thiobarbituric Acid Reactive Substances; Vitamin A; Vitamin E; Vitamins | 1996 |
On the connection between inherent DNA flexure and preferred binding of hydroxymethyluracil-containing DNA by the type II DNA-binding protein TF1.
Topics: Bacillus Phages; Base Sequence; Binding Sites; DNA Probes; DNA-Binding Proteins; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pentoxyl; Protein Binding; Thymine; Viral Proteins | 1996 |
The paradoxical influence of thymine analogues on restriction endonuclease cleavage of oligodeoxynucleotides.
Topics: Binding Sites; Deoxyribonucleases, Type II Site-Specific; Electrophoresis, Polyacrylamide Gel; Fluoresceins; Fluorescence; Fluorescent Dyes; Hydrolysis; Kinetics; Molecular Structure; Oligodeoxyribonucleotides; Pentoxyl; Thymine; Uracil | 1996 |
DNA bases attack by reactive metabolites produced during carbon tetrachloride biotransformation and promotion of liver microsomal lipid peroxidation.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Cytosine; DNA Adducts; DNA Damage; Guanine; Lipid Peroxidation; Male; Microsomes, Liver; Pentoxyl; Pyrimidines; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Thymine | 1997 |
Twin hydroxymethyluracil-A base pair steps define the binding site for the DNA-binding protein TF1.
Topics: Bacillus subtilis; Bacteriophages; Base Sequence; Binding Sites; DNA-Binding Proteins; DNA, Viral; Escherichia coli; Molecular Sequence Data; Pentoxyl; Sequence Analysis; Viral Proteins | 1997 |
Transfection enhancement in Bacillus subtilis displays features of a novel DNA repair pathway. I: DNA base and nucleolytic specificity.
Topics: Bacillus subtilis; Bacteriophages; Base Composition; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli Proteins; N-Glycosyl Hydrolases; Pentoxyl; Pyrimidines; Substrate Specificity; Thymine; Transfection; Ultraviolet Rays; Uracil-DNA Glycosidase | 1997 |
Transfection enhancement in Bacillus subtilis displays features of a novel DNA repair pathway. II: Host constitutive expression, repair DNA synthesis, and in vitro activity.
Topics: Bacillus subtilis; Bacterial Proteins; Bacteriophages; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; DNA, Bacterial; DNA, Viral; Pentoxyl; Polyethylene Glycols; Substrate Specificity; Transfection; Ultraviolet Rays | 1997 |
Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases.
Topics: Adenine; Animals; Cattle; Cytosine; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Guanine Deaminase; Oxidation-Reduction; Pentoxyl; Sulfhydryl Compounds; Temperature | 1998 |
Quantification of 5-(hydroxymethyl)uracil in DNA by gas chromatography/mass spectrometry: problems and solutions.
Topics: DNA; Formates; Gas Chromatography-Mass Spectrometry; Hydrolysis; Indicators and Reagents; Oligonucleotides; Pentoxyl; Spectrophotometry, Ultraviolet | 1998 |
Urine 8-oxo-7,8-dihydro-2-deoxyguanosine vs. 5-(hydroxymethyl) uracil as DNA oxidation marker in adriamycin-treated patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antibiotics, Antineoplastic; Deoxyguanosine; DNA; Doxorubicin; Female; Humans; Male; Neoplasms; Oxidation-Reduction; Pentoxyl; Thiobarbituric Acid Reactive Substances | 1998 |
Clinical variability in three Danish patients with dihydropyrimidine dehydrogenase deficiency all homozygous for the same mutation.
Topics: Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Dihydrouracil Dehydrogenase (NADP); Female; Homozygote; Humans; Infant; Male; Mutation; Netherlands; Oxidoreductases; Pentoxyl; Thymine; Uracil | 1998 |
Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.
Topics: Animals; Base Pairing; Binding Sites; Bromodeoxyuridine; DNA; Gene Expression Regulation; Glucosides; Pentoxyl; Trypanosoma brucei brucei; Uracil; Variant Surface Glycoproteins, Trypanosoma | 1998 |
Affinity, stability and polarity of binding of the TATA binding protein governed by flexure at the TATA Box.
Topics: Base Pairing; Base Sequence; Binding Sites; DNA; DNA Footprinting; DNA-Binding Proteins; Half-Life; Kinetics; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Pentoxyl; RNA Polymerase III; Saccharomyces cerevisiae; TATA Box; TATA-Box Binding Protein; Templates, Genetic; Thermodynamics; Transcription Factor TFIIIB; Transcription Factors; Transcription, Genetic | 1998 |
Determination of oxidative DNA base damage by gas chromatography-mass spectrometry. Effect of derivatization conditions on artifactual formation of certain base oxidation products.
Topics: Adenine; Animals; Artifacts; Cytosine; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Hydantoins; Hydrolysis; Nitrogen; Oxidation-Reduction; Pentoxyl; Purines; Pyrimidines; Temperature; Time Factors | 1998 |
Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil- and 5-hydroxymethyluracil-containing oligonucleotides.
Topics: Animals; Base Pairing; DNA Glycosylases; DNA Replication; DNA Restriction Enzymes; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Oligonucleotides; Pentoxyl; Uracil | 1999 |
Enzymatic repair of 5-formyluracil. I. Excision of 5-formyluracil site-specifically incorporated into oligonucleotide substrates by alka protein (Escherichia coli 3-methyladenine DNA glycosylase II).
Topics: Adenine; Base Pair Mismatch; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli; Guanine; Kinetics; Magnetic Resonance Spectroscopy; Methylnitronitrosoguanidine; Molecular Structure; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Pentoxyl; Substrate Specificity; Thymine; Uracil | 1999 |
The effect of experimental conditions on the levels of oxidatively modified bases in DNA as measured by gas chromatography-mass spectrometry: how many modified bases are involved? Prepurification or not?
Topics: Adenine; Animals; Artifacts; Cattle; Cytosine; DNA; Gas Chromatography-Mass Spectrometry; Guanine; Hydrolysis; Nucleotides; Oxidation-Reduction; Pentoxyl; Trifluoroacetic Acid; Uracil | 1999 |
Simultaneous determination of five oxidative DNA lesions in human urine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxyguanosine; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Isotope Labeling; Nucleosides; Oxidation-Reduction; Pentoxyl; Reproducibility of Results | 1999 |
NMR-derived solution structure of a 17mer hydroxymethyluracil-containing DNA.
Topics: Base Pairing; Base Sequence; DNA; Hydrogen Bonding; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pentoxyl; Protons; Software; Solutions | 1999 |
Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine and 5-(hydroxymethyl) uracil in smokers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Case-Control Studies; Deoxyguanosine; DNA Damage; Free Radicals; Humans; Male; Middle Aged; Oxidation-Reduction; Pentoxyl; Smoking | 1999 |
5-chloro-2'-deoxyuridine cytotoxicity results from base excision repair of uracil subsequent to thymidylate synthase inhibition.
Topics: Animals; Antineoplastic Agents; Base Pairing; Cell Line; Cricetinae; Cricetulus; Deoxyuridine; DNA; DNA Damage; DNA Glycosylases; DNA Repair; N-Glycosyl Hydrolases; Pentoxyl; Thymidylate Synthase; Uracil | 2000 |
Specificity of hydroxylmethyluracil-containing DNA for transcription factor 1: structural insights.
Topics: Binding Sites; DNA; DNA-Binding Proteins; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Oligodeoxyribonucleotides; Pentoxyl; Viral Proteins | 1999 |
An unexpectedly high excision capacity for mispaired 5-hydroxymethyluracil in human cell extracts.
Topics: Adenine; Base Pairing; Cell Extracts; Cell Line; DNA Damage; DNA Glycosylases; DNA Repair; Fibroblasts; Guanine; HeLa Cells; Humans; N-Glycosyl Hydrolases; Pentoxyl | 2000 |
Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Cell Cycle; Cell Membrane; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Nucleotidylexotransferase; DNA Repair; Fibroblasts; Fluorescein-5-isothiocyanate; G2 Phase; Genes, p53; HL-60 Cells; Humans; Lung; Mice; Mutation; Pentoxyl; Phosphatidylserines; Thymidine; Tumor Suppressor Protein p53 | 2001 |
High-affinity DNA binding of HU protein from the hyperthermophile Thermotoga maritima.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Base Sequence; Binding Sites; Chromatin; Conserved Sequence; DNA; DNA Probes; DNA-Binding Proteins; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pentoxyl; Protein Binding; Sequence Alignment; Thermodynamics; Thermotoga maritima; Titrimetry | 2001 |
Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1.
Topics: Amino Acid Sequence; Animals; Cattle; DNA Glycosylases; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; N-Glycosyl Hydrolases; Pentoxyl; Uracil-DNA Glycosidase | 2001 |
Nucleic acid analogues and the origins of replication.
Topics: Adenine; DNA; Guanine; Hydrogen Cyanide; Models, Chemical; Pentoxyl | 1989 |
The role of surface-exposed lysines in wrapping DNA about the bacterial histone-like protein HU.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus Phages; Bacillus subtilis; Bacterial Proteins; Binding Sites; Conserved Sequence; DNA-Binding Proteins; DNA, Viral; Histones; Kinetics; Lysine; Molecular Sequence Data; Nucleic Acid Conformation; Pentoxyl; Sequence Homology, Amino Acid; Thymine; Viral Proteins | 2002 |
Endogenous DNA lesions can inhibit the binding of the AP-1 (c-Jun) transcription factor.
Topics: Adenine; Base Pair Mismatch; Binding, Competitive; Cytosine; DNA Damage; DNA Glycosylases; DNA-Binding Proteins; Humans; N-Glycosyl Hydrolases; Nucleic Acid Heteroduplexes; Oligonucleotides; Pentoxyl; Protein Binding; Proto-Oncogene Proteins c-jun; Thymine; Transcription Factor AP-1; Uracil; Uracil-DNA Glycosidase | 2002 |
Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases.
Topics: Base Pair Mismatch; Base Sequence; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Guanine; N-Glycosyl Hydrolases; Oligonucleotides; Pentoxyl; Substrate Specificity | 2003 |
Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.
Topics: Amino Acid Sequence; Animals; Base Pair Mismatch; Base Pairing; Base Sequence; Cytosine; DNA Damage; DNA Glycosylases; DNA Repair; Humans; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; N-Glycosyl Hydrolases; Pentoxyl; Protein Conformation; Sequence Homology, Amino Acid; Substrate Specificity; Uracil-DNA Glycosidase; Xenopus laevis; Xenopus Proteins | 2003 |
Binding activity of replication protein A to single-stranded DNA containing oxidized pyrimidine base.
Topics: Animals; Base Sequence; Binding Sites; DNA Damage; DNA-Binding Proteins; DNA, Single-Stranded; Oligonucleotides; Oxidation-Reduction; Pentoxyl; Pyrimidines; Replication Protein A; Thymine; Uracil; Xenopus laevis | 2001 |
Surface salt bridges modulate DNA wrapping by the type II DNA-binding protein TF1.
Topics: Alanine; Anions; Aspartic Acid; Bacillus subtilis; Bacteriophages; Cations; Cross-Linking Reagents; Dimerization; DNA; DNA-Binding Proteins; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Glutaral; Ions; Kinetics; Lysine; Models, Molecular; Mutation; Pentoxyl; Plasmids; Protein Binding; Salts; Thermotoga maritima; Thymine; Viral Proteins | 2003 |
The new occurrence of a new pyrimidine base replacing thymine in a bacteriophage DNA:5-hydroxymethyl uracil.
Topics: Bacteriophages; DNA; DNA, Viral; Pentoxyl; Pyrimidines; Thymine; Uracil | 1962 |
CONVERSION OF THYMINE TO 5-HYDROXYMETHYLURACIL IN A CELL-FREE SYSTEM.
Topics: Autoradiography; Cell-Free System; Chromatography; Dialysis; Glutathione; Metabolism; NADP; Neurospora; Pentoxyl; Pharmacology; Pyrimidines; Renal Dialysis; Research; Thymine; Uracil | 1964 |
Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.
Topics: Calibration; Chromatography, High Pressure Liquid; Cobalt Radioisotopes; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Gamma Rays; Models, Chemical; Nitrogen; Oxygen; Pentoxyl; Photons; Spectrophotometry; Synchrotrons; Thymine; Time Factors; Uracil; X-Rays | 2004 |
Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.
Topics: Amino Acid Sequence; Catalysis; DNA Damage; DNA Glycosylases; DNA Mutational Analysis; DNA Repair; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pentoxyl; Structural Homology, Protein; Uracil; Uracil-DNA Glycosidase; Xenopus Proteins | 2004 |
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.
Topics: Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA, Complementary; Escherichia coli; Humans; Hydrogen Peroxide; Mutation; Oligonucleotides; Pentoxyl; Thymine; Uracil | 2005 |
Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animal Feed; Animals; Deoxyguanosine; Diet; DNA; DNA Damage; Guanine; Humans; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxidative Stress; Pentoxyl | 2004 |
Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.
Topics: Adenine; Adult; Aged; Biomarkers; DNA Adducts; DNA Damage; Female; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Lipid Peroxidation; Male; Middle Aged; Pentoxyl; Smoking; Thiobarbituric Acid Reactive Substances | 2005 |
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.
Topics: Animals; Cell Line; DNA Damage; DNA Glycosylases; DNA Polymerase beta; DNA Repair; Fibroblasts; HeLa Cells; Humans; Mice; Oxidants; Oxidation-Reduction; Pentoxyl; Uracil-DNA Glycosidase | 2005 |
Experimental study of hepatoprotective activity of hydroxymethyluracil.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Liver; Male; Pentoxyl; Rats | 2007 |
Correction of morphological shifts in experimental syringomyelia.
Topics: Animals; Disease Models, Animal; Pentoxyl; Rabbits; Syringomyelia | 2007 |
Opposite effects of 5-hydroxymethyluracil on mitogenic response of T cells stimulated through T-cell receptor or through T-cell receptor and CD28 co-receptor molecule.
Topics: Adjuvants, Immunologic; CD28 Antigens; Cells, Cultured; Humans; Lymphocyte Activation; Pentoxyl; Receptors, Antigen, T-Cell; T-Lymphocytes | 2010 |
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.
Topics: 5-Methylcytosine; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; DNA-Binding Proteins; Humans; Pentoxyl; Thymine DNA Glycosylase | 2012 |
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Topics: Animals; beta-Galactosidase; Cell Line; DNA Repair; Fibroblasts; Fluorouracil; Gene Targeting; Genetic Predisposition to Disease; Longevity; Mice; Mice, Inbred C57BL; Mice, Knockout; MutS Homolog 2 Protein; Neoplasms, Experimental; Pentoxyl; Thymidine; Uracil-DNA Glycosidase | 2012 |
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors.
Topics: Antitubercular Agents; Cell Line, Tumor; Cell Survival; Drug Resistance, Bacterial; Humans; Mycobacterium avium; Mycobacterium bovis; Mycobacterium tuberculosis; Pentoxyl; Pyrimidine Nucleosides; Uracil | 2012 |
Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.
Topics: Animals; Base Pair Mismatch; DNA; DNA Glycosylases; Endodeoxyribonucleases; Mice; Models, Molecular; Pentoxyl; Protein Structure, Tertiary; Thymine | 2012 |
Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Topics: 5-Methylcytosine; Bacteria; Catalytic Domain; Cytosine; DNA; Endodeoxyribonucleases; Humans; Models, Molecular; Pentoxyl; Protein Structure, Tertiary; Substrate Specificity; Thymine; Thymine DNA Glycosylase | 2012 |
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.
Topics: Biocatalysis; Catalytic Domain; Cytosine; DNA; Humans; Models, Molecular; Pentoxyl; Thymine DNA Glycosylase | 2012 |
A micro-extraction technique using a new digitally controlled syringe combined with UHPLC for assessment of urinary biomarkers of oxidatively damaged DNA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Analysis of Variance; Biomarkers; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Damage; Female; Humans; Limit of Detection; Liquid Phase Microextraction; Male; Middle Aged; Molecular Structure; Oxidative Stress; Pentoxyl; Reactive Oxygen Species; Syringes; Tandem Mass Spectrometry | 2013 |
Side-by-side comparison of DNA damage induced by low-energy electrons and high-energy photons with solid TpTpT trinucleotide.
Topics: Chromatography, High Pressure Liquid; DNA Damage; Electrons; Oligonucleotides; Pentoxyl; Photons; Radiation, Ionizing; Tandem Mass Spectrometry; Thymine; Uracil | 2013 |
A new and fast methodology to assess oxidative damage in cardiovascular diseases risk development through eVol-MEPS-UHPLC analysis of four urinary biomarkers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Calibration; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyguanosine; Disease Progression; Female; Humans; Hydrogen-Ion Concentration; Hypercholesterolemia; Hypertension; Limit of Detection; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Pentoxyl; Reproducibility of Results; Risk Factors; Solid Phase Microextraction; Uric Acid | 2013 |
Effect of intermolecular hydrogen bonding, vibrational analysis and molecular structure of a biomolecule: 5-Hydroxymethyluracil.
Topics: Computer Simulation; Hydrogen Bonding; Models, Chemical; Molecular Dynamics Simulation; Pentoxyl; Spectroscopy, Fourier Transform Infrared | 2014 |
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
Topics: 5-Methylcytosine; Animals; Base Sequence; Carbon Isotopes; Chromatin Assembly and Disassembly; Chromatography, Liquid; Cytosine; Dioxygenases; DNA; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression; Mice; Molecular Sequence Data; Oxidation-Reduction; Pentoxyl; Protein Binding; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine; Transcription Factors | 2014 |
Polymerase synthesis of photocaged DNA resistant against cleavage by restriction endonucleases.
Topics: DNA; DNA Restriction Enzymes; DNA-Directed DNA Polymerase; Pentoxyl; Ultraviolet Rays | 2014 |
Identification of the glucosyltransferase that converts hydroxymethyluracil to base J in the trypanosomatid genome.
Topics: DNA, Protozoan; Epigenesis, Genetic; Gene Knockout Techniques; Genome, Protozoan; Glucosides; Glucosyltransferases; Mutagenesis, Site-Directed; Pentoxyl; Protozoan Proteins; RNA Interference; RNA, Messenger; RNA, Protozoan; Substrate Specificity; Thymine; Trypanosoma brucei brucei; Uracil | 2014 |
DNA metabolism: bases of DNA repair and regulation.
Topics: Animals; Dioxygenases; DNA; DNA-Binding Proteins; Embryonic Stem Cells; Pentoxyl; Proto-Oncogene Proteins; Thymine | 2014 |
Thermodynamics of organic molecule adsorption on sorbents modified with 5-hydroxy-6-methyluracil by inverse gas chromatography.
Topics: Adsorption; Alcohols; Alkanes; Chromatography, Gas; Crystallography, X-Ray; Entropy; Hydrogen Bonding; Molecular Conformation; Pentoxyl; Porosity; Surface Properties | 2014 |
The effect of Pot1 binding on the repair of thymine analogs in a telomeric DNA sequence.
Topics: Base Sequence; Binding Sites; DNA; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Fluorouracil; Pentoxyl; Protein Binding; Schizosaccharomyces pombe Proteins; Shelterin Complex; Telomere; Telomere-Binding Proteins; Uracil; Uracil-DNA Glycosidase | 2014 |
Comparison of the absolute level of epigenetic marks 5-methylcytosine, 5-hydroxymethylcytosine, and 5-hydroxymethyluracil between human leukocytes and sperm.
Topics: 5-Methylcytosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Leukocytes; Male; Pentoxyl; Poland; Spectrometry, Mass, Electrospray Ionization; Spermatozoa; Tandem Mass Spectrometry; Thymidine; Up-Regulation | 2014 |
In silico studies to explore the mutagenic ability of 5-halo/oxy/li-oxy-uracil bases with guanine of DNA base pairs.
Topics: Base Pairing; Computer Simulation; Cytosine; DNA; Guanine; Halogens; Hydrogen Bonding; Models, Genetic; Mutagenesis; Pentoxyl; Static Electricity; Uracil | 2014 |
Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling.
Topics: Animals; Deamination; DNA; DNA Methylation; Epigenomics; Mammals; Models, Biological; Pentoxyl | 2015 |
Selective Chemical Labeling of Natural T Modifications in DNA.
Topics: Base Sequence; DNA; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pentoxyl; Thymine; Uracil | 2015 |
Urinary 5-hydroxymethyluracil and 8-oxo-7,8-dihydroguanine as potential biomarkers in patients with colorectal cancer.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Biomarkers, Tumor; Colorectal Neoplasms; Female; Guanine; Humans; Male; Middle Aged; Pentoxyl | 2015 |
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Topics: Base Pair Mismatch; Catalytic Domain; Crystallography, X-Ray; DNA; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pentoxyl; Protein Binding; Thymine; Thymine DNA Glycosylase; Uracil | 2015 |
Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi.
Topics: Biocatalysis; Catalytic Domain; Fungal Proteins; Ketoglutaric Acids; Mixed Function Oxygenases; Mutagenesis; Neurospora crassa; Pentoxyl; Protein Binding; Substrate Specificity; Thymine; Uracil | 2015 |
Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA.
Topics: DNA; DNA-Binding Proteins; Epigenesis, Genetic; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; Nanopores; Nucleic Acid Denaturation; Oxidation-Reduction; Pentoxyl; Protein Binding; Surface Properties; Thymine | 2016 |
Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.
Topics: 5-Methylcytosine; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cytosine; Dioxygenases; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression; Kidney; Liver; Lung; Male; Myocardium; Organ Specificity; Pentoxyl; Rats; Rats, Wistar; Swine; Tandem Mass Spectrometry; Thymus Gland | 2015 |
Base J glucosyltransferase does not regulate the sequence specificity of J synthesis in trypanosomatid telomeric DNA.
Topics: DNA, Protozoan; Glucosyltransferases; Kinetics; Leishmania; Pentoxyl; Protozoan Proteins; Telomere; Thymine | 2015 |
An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation.
Topics: 5-Methylcytosine; Animals; Cell Line; Cell Line, Tumor; DNA; DNA Mismatch Repair; DNA Repair; Gene Expression; Humans; Mice; Mice, Knockout; MutS Homolog 2 Protein; Pentoxyl; Promoter Regions, Genetic; Uracil | 2016 |
Spontaneous Oligomerization of Nucleotide Alternatives in Aqueous Solutions.
Topics: 5-Methylcytosine; Evolution, Chemical; Hot Temperature; Origin of Life; Pentoxyl; Polymerization; Water | 2017 |
Eight new crystal structures of 5-(hydroxymethyl)uracil, 5-carboxyuracil and 5-carboxy-2-thiouracil: insights into the hydrogen-bonded networks and the predominant conformations of the C5-bound residues.
Topics: Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Pentoxyl; Thiouracil; Uracil | 2016 |
Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA.
Topics: 5-Methylcytosine; Ascorbic Acid; Cytosine; DNA; DNA Methylation; HCT116 Cells; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Pentoxyl; Proto-Oncogene Proteins; Spectrometry, Mass, Electrospray Ionization; Thymine | 2016 |
Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania.
Topics: Chromosome Mapping; DNA, Protozoan; Glucosides; Leishmania; Pentoxyl; Uracil | 2017 |
5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase.
Topics: Cytosine; DNA-Directed RNA Polymerases; Epigenesis, Genetic; Escherichia coli; Pentoxyl; Transcription, Genetic | 2017 |
i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions.
Topics: Adenine; Cytosine; DNA; DNA Damage; Humans; Pentoxyl; Telomere; Uracil | 2018 |
Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA.
Topics: DNA; DNA-Directed DNA Polymerase; Light; Models, Molecular; Nucleic Acid Conformation; Nucleotides; Pentoxyl; Photochemical Processes | 2018 |
UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans.
Topics: Animals; Apoptosis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Endonucleases; Germ Cells; Longevity; Loss of Function Mutation; Pentoxyl; Uracil-DNA Glycosidase | 2018 |
5-formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively.
Topics: Biomarkers; Cytosine; Dioxygenases; DNA-Binding Proteins; Humans; Mutation; Myelodysplastic Syndromes; Pentoxyl; Phosphoproteins; Proto-Oncogene Proteins; RNA Splicing Factors | 2020 |
Translesion DNA Synthesis Across Lesions Induced by Oxidative Products of Pyrimidines: An Insight into the Mechanism by Microscale Thermophoresis.
Topics: DNA; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; HIV-1; Humans; Mutagens; Oxidation-Reduction; Oxidative Stress; Pentoxyl; Pyrimidines; Thermodynamics; Uracil | 2019 |
Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding.
Topics: 5-Methylcytosine; Breast Neoplasms; Cell Line, Tumor; DNA; Epigenesis, Genetic; Female; Humans; Hydrogels; Microfluidics; Neoplasm Invasiveness; Pentoxyl; Single-Cell Analysis | 2020 |
Detection of Low-Abundance DNA Modifications Using Signal Amplification-Based Immunocytochemistry.
Topics: 5-Methylcytosine; Animals; Antibodies; Cell Nucleus; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Humans; Immunohistochemistry; Pentoxyl; Peroxidase | 2021 |
Analysis of 5-Hydroxymethyluracil Levels Using Flow Cytometry.
Topics: 5-Methylcytosine; Chromatography, Liquid; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Flow Cytometry; Humans; Oxidation-Reduction; Pentoxyl; Single-Cell Analysis; Tandem Mass Spectrometry; Thymine | 2021 |
Quantum Computational, Spectroscopic (FT-IR, FT-Raman, NMR, and UV-Vis) Hirshfeld Surface and Molecular Docking-Dynamics Studies on 5-Hydroxymethyluracil (Monomer and Trimer).
Topics: Humans; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Pentoxyl; Quantum Theory; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Thermodynamics | 2023 |
Bioorthogonal Reaction-Mediated Enzymatic Elongation-Driven Dendritic Nanoassembly for Genome-Wide Analysis of 5-Hydroxymethyluracil in Breast Tissues.
Topics: Cell Line; DNA; Humans; Pentoxyl | 2023 |