pentostatin and purine
pentostatin has been researched along with purine* in 2 studies
Reviews
1 review(s) available for pentostatin and purine
| Article | Year |
|---|---|
Purine analogs in leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia; Pentostatin; Purines; Stem Cell Transplantation; Vidarabine | 2004 |
Other Studies
1 other study(ies) available for pentostatin and purine
| Article | Year |
|---|---|
Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.
Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purines (15-27), 9-(p-toluenesulfonyl/cyclopentyl/ethoxycarbonylmethyl)-6-(substituted amino/piperazino)purines (28-34, 36, 37, 38-41) were synthesized and evaluated initially for their cytotoxic activities on liver Huh7, breast T47D and colon HCT116 carcinoma cells. N(6)-(4-Trifluoromethylphenyl)piperazine derivative (17) and its 9-(p-toluene-sulfonyl)/9-cyclopentyl analogues (28, 36) had promising cytotoxic activities. Compounds 17, 28 and 36 were further analysed for their cytotoxicity in a panel of a liver cancer cell lines. The compound 36 had better cytotoxic activities (IC50 ≤ 1 μM) than the nucleobase 5-FU and nucleosides fludarabine, cladribine, and pentostatine on Huh7 cells. Cytotoxicity induced by 36 was later identified as senescence associated cell death by SA-β-Gal assay. Topics: Antineoplastic Agents; Cell Death; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Hep G2 Cells; Humans; Models, Molecular; Molecular Structure; Purines; Structure-Activity Relationship; Tumor Cells, Cultured | 2015 |