pentostatin and nebularine

pentostatin has been researched along with nebularine* in 1 studies

Other Studies

1 other study(ies) available for pentostatin and nebularine

Article	Year
Inhibition of adenosine deaminase by azapurine ribonucleosides. Biochemical pharmacology, 1992, Nov-03, Volume: 44, Issue:9 We have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but did not lower the Ki value for coformycin. Evaluation of these compounds in a MOLT-4 growth assay revealed that 2-azacoformycin was as effective as 2'-deoxycoformycin in potentiating growth inhibition by 2'-deoxyadenosine. The azapurine nucleosides merit further study as antitumor agents. Topics: Adenosine Deaminase Inhibitors; Antineoplastic Agents; Cell Division; Deoxyadenosines; Kinetics; Pentostatin; Purine Nucleosides; Ribonucleosides; Structure-Activity Relationship; T-Lymphocytes	1992

Article

Year

Inhibition of adenosine deaminase by azapurine ribonucleosides.

Biochemical pharmacology, 1992, Nov-03, Volume: 44, Issue:9

We have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but did not lower the Ki value for coformycin. Evaluation of these compounds in a MOLT-4 growth assay revealed that 2-azacoformycin was as effective as 2'-deoxycoformycin in potentiating growth inhibition by 2'-deoxyadenosine. The azapurine nucleosides merit further study as antitumor agents.

Topics: Adenosine Deaminase Inhibitors; Antineoplastic Agents; Cell Division; Deoxyadenosines; Kinetics; Pentostatin; Purine Nucleosides; Ribonucleosides; Structure-Activity Relationship; T-Lymphocytes

1992