pentobarbital has been researched along with pregnanolone in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 37 (58.73) | 18.2507 |
| 2000's | 21 (33.33) | 29.6817 |
| 2010's | 4 (6.35) | 24.3611 |
| 2020's | 1 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Acosta-Burruel, M; Alauddin, M; Bolger, MB; Gee, KW; Hawkinson, JE; Hogenkamp, DJ; Kimbrough, CL; Lan, NC; Tahir, SH; Upasani, RB; Whittemore, ER; Woodward, RM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Prince, RJ; Simmonds, MA | 1 |
| Allen, PM; Melchior, CL | 1 |
| Gee, KW; Lan, NC | 1 |
| Blakeman, DP; Im, WB | 1 |
| Ayer, DE; Blakeman, DP; Davis, JP; Im, WB | 1 |
| Costa, E; Paul, SM; Pritchett, DB; Puia, G; Purdy, RH; Santi, MR; Seeburg, PH; Vicini, S | 1 |
| Dartois, E; Fillion, G; Haour, F; Moyse, E; Vincens, M | 1 |
| Ator, NA; Grant, KA; Griffiths, RR; Paul, SM; Purdy, RH | 1 |
| Bähring, R; Grantyn, R; Martelli, EA; Standhardt, H | 1 |
| Bain, CJ; Kemp, JA; McKernan, RM; Quirk, K; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Jussofie, A | 1 |
| Bain, C; Garrett, EM; Hadingham, KL; Heavens, RP; Sirinathsinghji, DJ; Wafford, KA; Whiting, PJ | 1 |
| Hay, M; Ticku, MK; Yu, R | 1 |
| Azarov, A; Bowen, CA; Grant, KA; Mirkis, S; Purdy, RH | 1 |
| Akaike, N; Harata, N; Shimura, M; Tamai, M | 1 |
| Akaike, N; Harata, N; Wu, J | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Belelli, D; Hill-Venning, C; Lambert, JJ; Peters, JA | 1 |
| Davies, PA; Hales, TG; Kirkness, EF | 1 |
| Feltz, P; Poisbeau, P; Schlichter, R | 1 |
| Akaike, N; Imanishi, T; Xu, TL | 1 |
| Vanover, KE | 2 |
| Barros, HM; Manitiu, A; Miczek, KA; Vivian, JA | 1 |
| Bhave, SV; Hoffmann, E; Hoffmann, PL; Olsen, RW; Tabakoff, B; Tobin, AJ; Tyndale, RF | 1 |
| Brozowski, S; Chuang, L; Hadingham, K; Harris, RA; Valenzuela, CF; Whiting, PJ | 1 |
| Bowen, CA; Grant, KA | 1 |
| Bowen, CA; Gatto, GJ; Grant, KA | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Alkana, RL; Bolger, MB; Brinton, RD; Davies, DL; Finn, DA | 1 |
| Chistina Grobin, A; Devaud, LL; Inglefield, JR; Morrow, AL; Schwartz-Bloom, RD | 1 |
| Belelli, D; Lambert, JJ; Peters, JA; Pistis, M | 1 |
| Costa, E; Guidotti, A; Matsumoto, K; Mienville, JM; Pinna, G; Taki, K; Uzunov, DP; Uzunova, V; Watanabe, H | 1 |
| Fiszer de Plazas, S; Mitridate de Novara, AM; Rodríguez Gil, DJ; Viapiano, MS | 1 |
| Carter, RB; Edgar, DM; Fick, DB; Gee, KW; Hogenkamp, DJ; Lan, NC; Seidel, WF; Vanover, KE | 1 |
| Sapp, DW; Yeh, HH | 1 |
| Dekermendjian, K; Hartvig, L; Liljefors, T; Lükensmejer, B | 1 |
| Fiszer de Plazas, S; Rodríguez Gil, DJ; Viapiano, MS | 1 |
| Jaako, K; Kaasik, A; Kalda, A; Zharkovsky, A | 1 |
| Findlay, GS; Harris, RA; Harrison, NL; Ueno, S | 1 |
| Adkins, CE; Bonnert, TP; Gonzalez, JE; Haldon, C; Kerby, J; McKernan, RM; Oades, K; Pillai, GV; Simpson, PB; Whiting, PJ | 1 |
| Alkana, RL; Bolger, MB; Davies, DL; McCauley, LD | 1 |
| Hodge, CW; Kelley, SP; Mehmert, KK; Nannini, MA; Olive, MF | 1 |
| Simmonds, MA; Sooksawate, T | 1 |
| France, CP; McMahon, LR | 2 |
| Fiszer de Plazas, S; Mitridate de Novara, A; Rodríguez Gil, DJ | 1 |
| Bäckström, T; Lundgren, P; Strömberg, J; Wang, M | 1 |
| Grant, KA; Porcu, P | 1 |
| McKinnon, CS; Meyer, PJ; Palmer, AA; Phillips, TJ | 1 |
| France, CP; Gerak, LR; McMahon, LR | 1 |
| France, CP; Javors, MA; McMahon, LR | 1 |
| Betts, BA; Gill, N; Griffith, TN; Hall, AC; Humbert, DJ; Jenkins, A; Kelly, EW; Kotey, FO; Rowan, KC; Veneskey, KC; Watt, EE | 1 |
| Gerak, LR | 1 |
| Akk, G; Bracamontes, J; Li, P; Steinbach, JH | 1 |
| Calignano, A; Citraro, R; Cuzzocrea, S; D'Agostino, G; De Sarro, G; Iacono, A; La Rana, G; Meli, R; Piazza, PV; Russo, E; Russo, R; Sasso, O; Vitiello, S | 1 |
| Coyne, L; Halliwell, RF; Hirakawa, R; Przyborski, SA; Shan, M | 1 |
| Chesnoy-Marchais, D | 1 |
| Akk, G; Burbridge, AB; Germann, AL; Pierce, SR; Steinbach, JH | 1 |
| Benz, A; Lambert, PM; Mennerick, S; Ni, R; Rensing, NR; Wong, M; Zorumski, CF | 1 |
63 other study(ies) available for pentobarbital and pregnanolone
| Article | Year |
|---|---|
Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Desoxycorticosterone; Electrophysiology; Female; In Vitro Techniques; Models, Molecular; Oocytes; Rats; Receptors, GABA-A; Xenopus | 1997 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
5 beta-pregnan-3 beta-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor-complex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Flunitrazepam; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pentobarbital; Pregnanolone; Rats; Rats, Inbred Strains | 1992 |
Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pentobarbital; Pregnanolone; Pregnenolone; Seizures; Sleep; Time Factors | 1992 |
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes | 1991 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Studies on the mechanism of interactions between anesthetic steroids and gamma-aminobutyric acidA receptors.
Topics: Anesthetics; Animals; Chlorides; Desoxycorticosterone; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Nipecotic Acids; Pentobarbital; Pregnanolone; Progesterone; Proline; Rats; Receptors, GABA-A; Synaptic Membranes | 1990 |
Neurosteroids act on recombinant human GABAA receptors.
Topics: Benzodiazepines; Cell Line, Transformed; Cell Membrane Permeability; Chlorides; Desoxycorticosterone; Electric Conductivity; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Pentobarbital; Pregnanolone; Receptors, GABA-A; Recombinant Proteins; Transfection | 1990 |
An autoradiographic study comparing the interactions of 3 alpha-OH-5 alpha-pregnan-20-one, pregnenolone sulfate and pentobarbital with [3S]-TBPS binding sites and their modulation by GABA in different structures of the rat brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mesencephalon; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Drug discrimination analysis of endogenous neuroactive steroids in rats.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Discrimination Learning; Ethanol; Generalization, Stimulus; Lorazepam; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A | 1993 |
GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons?
Topics: Acetylcarnitine; Acetylcholine; Action Potentials; Animals; Bicuculline; Chloride Channels; Clonazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Potassium Chloride; Pregnanolone; Quinoxalines; Retina; Retinal Ganglion Cells; Strychnine; Substrate Specificity; Tetrodotoxin; Zinc | 1994 |
A novel allosteric modulatory site on the GABAA receptor beta subunit.
Topics: Allosteric Site; Animals; Anticonvulsants; Cells, Cultured; Chlorides; Drug Synergism; Electric Conductivity; Electrophysiology; Female; gamma-Aminobutyric Acid; Gene Expression; Humans; Pentobarbital; Pregnanolone; Rats; Receptors, GABA; Transfection; Triazoles; Xenopus | 1994 |
A new highly sensitive procedure--a prerequisite to evaluate the density of GABAA receptors and to study their allosteric properties in distinct areas of rat brain.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; Humans; Hydrogen-Ion Concentration; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.
Topics: Amino Acid Sequence; Animals; Antisense Elements (Genetics); Autoradiography; Base Sequence; Cerebellar Cortex; Cloning, Molecular; DNA Primers; DNA, Complementary; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Situ Hybridization; Kinetics; L Cells; Ligands; Macromolecular Substances; Membrane Potentials; Mice; Molecular Sequence Data; Oocytes; Pentobarbital; Polymerase Chain Reaction; Pregnanolone; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 1996 |
Chronic neurosteroid treatment attenuates single cell GABAA response and its potentiation by modulators in cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Down-Regulation; GABA Modulators; Mice; Mice, Inbred C57BL; Neurons; Pentobarbital; Pregnanolone; Radioligand Assay; Receptors, GABA-A | 1996 |
Ethanol-like discriminative stimulus effects of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in female Macaca fascicularis monkeys.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Female; Macaca fascicularis; Pentobarbital; Pregnanolone | 1996 |
Allosteric modulation of GABAA receptors in acutely dissociated neurons of the suprachiasmatic nucleus.
Topics: Allosteric Regulation; Animals; Bicuculline; Chlorides; Diazepam; Electric Conductivity; Female; GABA Antagonists; GABA-A Receptor Agonists; Intracellular Membranes; Male; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Suprachiasmatic Nucleus | 1996 |
Potentiation by sevoflurane of the gamma-aminobutyric acid-induced chloride current in acutely dissociated CA1 pyramidal neurones from rat hippocampus.
Topics: Animals; Chloride Channels; Diazepam; Drug Synergism; Ethers; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channel Gating; Methyl Ethers; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Sevoflurane | 1996 |
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship | 1997 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor.
Topics: Anesthetics, Intravenous; Animals; Etomidate; Humans; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis | 1997 |
Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells.
Topics: Anesthetics, General; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; gamma-Aminobutyric Acid; Humans; Pentobarbital; Pregnanolone; Propofol; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Sulfur Radioisotopes | 1997 |
Modulation of GABAA receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model.
Topics: Animals; Animals, Newborn; Cells, Cultured; Electrophysiology; Female; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypothalamo-Hypophyseal System; Membrane Potentials; Pentobarbital; Pregnancy; Pregnanes; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
Modulation of the GABAA response in rat ventromedial hypothalamic neurons by pregnanolone.
Topics: Animals; Chloride Channels; Chlorides; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Transport; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Ventromedial Hypothalamic Nucleus | 1997 |
Discriminative stimulus effects of the endogenous neuroactive steroid pregnanolone.
Topics: Animals; Behavior, Animal; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Male; Pentobarbital; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Ultrasonic vocalizations in rat pups: modulation at the gamma-aminobutyric acidA receptor complex and the neurosteroid recognition site.
Topics: Alprazolam; Animals; Diazepam; Female; Male; Muscimol; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Vocalization, Animal | 1997 |
Pentobarbital decreases the gamma-aminobutyric acidA receptor subunit gamma-2 long/short mRNA ratio by a mechanism distinct from receptor occupation.
Topics: Animals; Ethanol; GABA Modulators; Hexobarbital; Pentobarbital; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA Splicing; RNA, Messenger | 1997 |
Adaptation of gamma-aminobutyric acid type A receptors to alcohol exposure: studies with stably transfected cells.
Topics: Animals; Cells, Cultured; Drug Tolerance; Ethanol; Flunitrazepam; Humans; Mice; Muscimol; Pentobarbital; Pregnanolone; Protein Kinase C; Receptors, GABA-A; Transfection; Zinc | 1998 |
Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using a three-choice ethanol-dizocilpine-water discrimination.
Topics: Animals; Diazepam; Discrimination, Psychological; Dizocilpine Maleate; Ethanol; GABA Modulators; Indoles; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists; Water | 1998 |
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water | 1997 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors | 1998 |
In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Diazepam; Ethanol; Flunitrazepam; GABA Modulators; Hyperbaric Oxygenation; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Pregnanolone; Receptors, GABA-A | 1999 |
Interaction of ethanol with excitatory amino acid receptor antagonists in mice.
Topics: Animals; Ataxia; Behavior, Animal; Benzodiazepines; Central Nervous System Depressants; Chlordiazepoxide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Isoquinolines; Male; Mice; Muscle Relaxation; Pentobarbital; Piperazines; Pregnanolone; Psychomotor Performance; Quinoxalines; Receptors, Glutamate; Tetrazoles | 1999 |
Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.
Topics: Animals; Central Nervous System Depressants; Chlorides; Diazepam; DNA Primers; Ethanol; Flunitrazepam; Fluorescent Dyes; GABA Agonists; GABA Modulators; Gene Expression; Mice; Muscimol; Neoplastic Stem Cells; Neuroglia; Pentobarbital; Pregnanolone; Quinolinium Compounds; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 1999 |
The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors.
Topics: Anesthetics; Animals; Drug Interactions; Electric Conductivity; Etomidate; Female; gamma-Aminobutyric Acid; Glycine; Mutagenesis, Site-Directed; Oocytes; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Receptors, Glycine; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 1999 |
Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss.
Topics: 5-alpha Reductase Inhibitors; Animals; Fluoxetine; Male; Mice; Pentobarbital; Prefrontal Cortex; Pregnanolone; Reflex, Abnormal; Selective Serotonin Reuptake Inhibitors | 1999 |
Synaptic membrane freezing affects modulatory sites in avian central nervous system GABA(A) receptor.
Topics: Animals; Binding Sites; Chickens; Drug Synergism; Freezing; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Pentobarbital; Picrotoxin; Pregnanolone; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes; Tectum Mesencephali; Tritium | 1999 |
Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids.
Topics: Animals; Conditioning, Operant; Depression, Chemical; Dose-Response Relationship, Drug; Electroencephalography; Hypnotics and Sedatives; Male; Pentobarbital; Postural Balance; Pregnanolone; Pregnenolone; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Steroids; Triazolam; Zolpidem | 1999 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc | 2000 |
Two conserved arginines in the extracellular N-terminal domain of the GABA(A) receptor alpha(5) subunit are crucial for receptor function.
Topics: Amino Acid Substitution; Animals; Arginine; Chlorides; CHO Cells; Cricetinae; Diazepam; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Ion Channel Gating; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Structure, Tertiary; Receptors, GABA-A; Sequence Alignment; Steroids; Structure-Activity Relationship; Transfection | 2000 |
Acute hypoxic hypoxia transiently reduces GABA(A) binding site number in developing chick optic lobe.
Topics: Acute Disease; Allosteric Regulation; Animals; Binding Sites; Chick Embryo; GABA Modulators; gamma-Aminobutyric Acid; Hypoxia; Optic Lobe, Nonmammalian; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors | 2000 |
Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Count; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebellum; Colchicine; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; GABA Modulators; Glucose; Glutamic Acid; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Pentobarbital; Picrotoxin; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism | 2001 |
Allosteric modulation in spontaneously active mutant gamma-aminobutyric acidA receptors.
Topics: Allosteric Regulation; Animals; Bicuculline; Electric Conductivity; Female; Flunitrazepam; GABA Antagonists; GABA Modulators; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Xenopus laevis | 2001 |
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
Topics: Animals; Benzodiazepines; Cell Line; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mice; Models, Biological; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Protein Binding; Protein Conformation; Receptors, GABA-A; Spectrometry, Fluorescence; Time Factors; Transfection | 2001 |
Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors.
Topics: Animals; Atmospheric Pressure; Chlorides; Chlorine; Flunitrazepam; GABA Modulators; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Pentobarbital; Pregnanolone; Radioisotopes; Receptors, GABA-A; Synaptosomes | 2001 |
Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hippocampus; Injections, Intraperitoneal; Male; Nucleus Accumbens; Pentobarbital; Pregnanolone; Rats; Rats, Long-Evans | 2001 |
Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.
Topics: Animals; Cell Membrane; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Pregnenolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A | 2001 |
Daily treatment with diazepam differentially modifies sensitivity to the effects of gamma-aminobutyric acid(A) modulators on schedule-controlled responding in rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Electroshock; Food; GABA Agonists; GABA Antagonists; GABA Modulators; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule; Triazolam | 2002 |
Acute hypoxic hypoxia alters GABA(A) receptor modulation by allopregnanolone and pentobarbital in embryonic chick optic lobe.
Topics: Anesthetics; Animals; Chick Embryo; GABA Modulators; Hypoxia; Neurons; Optic Lobe, Nonmammalian; Pentobarbital; Pregnanolone; Receptors, GABA-A; Synapses | 2002 |
Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnan-20-one (isoallopregnanolone).
Topics: Animals; Cerebral Cortex; Chlorides; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Osmolar Concentration; Pentobarbital; Pregnanolone; Rats; Rats, Wistar | 2003 |
Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Indoles; Midazolam; Pentobarbital; Phencyclidine; Piperazines; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1B; Serotonin Receptor Agonists | 2004 |
Behavioral sensitization to ethanol is modulated by environmental conditions, but is not associated with cross-sensitization to allopregnanolone or pentobarbital in DBA/2J mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Environment; Ethanol; Female; Mice; Mice, Inbred DBA; Motor Activity; Pentobarbital; Pregnanolone | 2005 |
Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Isoxazoles; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors; Triazolam; Women | 2005 |
Efficacy and the discriminative stimulus effects of negative GABAA modulators, or inverse agonists, in diazepam-treated rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2006 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2007 |
Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol.
Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Cyclohexanols; Flumazenil; Flunitrazepam; Menthol; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Xenopus | 2008 |
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.
Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Ketamine; Male; Midazolam; Morphine; Pentobarbital; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reinforcement Schedule; Substance-Related Disorders | 2009 |
Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.
Topics: Binding Sites; Cell Line; Diazepam; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutation; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Multimerization; Protein Subunits; Receptors, GABA-A | 2009 |
Palmitoylethanolamide modulates pentobarbital-evoked hypnotic effect in mice: involvement of allopregnanolone biosynthesis.
Topics: Amides; Animals; Brain Stem; Drug Synergism; Endocannabinoids; Ethanolamines; Hypnotics and Sedatives; Male; Mice; Palmitic Acids; Pentobarbital; PPAR alpha; Pregnanolone | 2010 |
Neuropharmacological properties of neurons derived from human stem cells.
Topics: Cell Differentiation; Chlordiazepoxide; Diazepam; gamma-Aminobutyric Acid; Glycine; Humans; Immunohistochemistry; Ion Channel Gating; Ligands; Mefenamic Acid; Neurons; Pentobarbital; Pregnanolone; Stem Cells; Tetraethylammonium; Tetrodotoxin | 2011 |
Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons.
Topics: Animals; beta-Alanine; Bicuculline; Brain Stem; Central Nervous System Agents; Chlorine; GABA Agents; Hypoglossal Nerve; Midazolam; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pentobarbital; Phosphinic Acids; Pregnanolone; Pyridazines; Pyridines; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Strychnine; Taurine; Tissue Culture Techniques | 2016 |
Steady-State Activation and Modulation of the Concatemeric
Topics: Allosteric Regulation; Animals; beta-Alanine; GABA-A Receptor Agonists; Multiprotein Complexes; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Xenopus laevis | 2019 |
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators.
Topics: Animals; Antidepressive Agents; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Humans; Ketamine; Mice; Neurosteroids; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2023 |