pentobarbital and indomethacin

pentobarbital has been researched along with indomethacin in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199024 (63.16)18.7374
1990's4 (10.53)18.2507
2000's7 (18.42)29.6817
2010's3 (7.89)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Caron, G; Ermondi, G1
Lombardo, F; Obach, RS; Waters, NJ1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Sen, S; Sinha, N1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dinnendahl, V; Gumulka, SW1
Arimura, A; Chihara, K; Chihara, M; Schally, AV1
Collins, AC; George, FR1
Grahame-Smith, DG; Green, AR; Heal, DJ1
Bartter, FC; Donahue, JJ; Kelly, GD; Yun, JC1
Bartter, FC; Kelly, GD; Tate, JE; Yun, JC1
Bauminger, A; Lindner, HR1
Chapnick, BM; Feigen, LP; Kadowitz, PJ; Klainer, E1
Duckrow, RB1
Chen, BB; Fehr, DM; Goll, HM; Murray, PA; Nyhan, DP1
Andersson, SE1
Misawa, M; Shiozaki, Y; Suzuki, T1
Hara, S; Morioka, S; Satoh, K; Yanagihara, S1
Clark, MR; Curry, TE; Dean, DD; LeMaire, WJ; Woessner, JF1
Jourdain, D; MacKenzie, ET; Nowicki, JP1
Filippelli, W; Guarino, V; Magliulo, R; Marmo, E; Rossi, F; Russo, S1
Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW1
Lamprecht, SA; Lindner, HR; Tsafriri, A; Zor, U1
Bauer, BJ; Brodie, DA; Cook, PG; Dagle, GE1
Coupar, IM; Lee, MK1
Satoh, S; Suzuki, M1
Bex, FJ; Corbin, A1
Collins, AC; George, FR; Jackson, SJ1
Provoost, AP1
Niida, H; Ohuchi, T; Okabe, S; Takeuchi, K1
Fant, RV; Henningfield, JE; Pickworth, WB1
Bolz, SS; de Wit, C; Esser, N; Lehr, HA; Pohl, U1
Saxena, NC1
Abbott, FV; Saddi, GM1
Arai, K; Fukuda, K; Hirakata, H; Nakagawa, T; Sato, M1
Comelli, F; Costa, B; Fowler, CJ; Holt, S1

Reviews

1 review(s) available for pentobarbital and indomethacin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for pentobarbital and indomethacin

ArticleYear
Inhibition of prostaglandin synthesis and effects of ethanol and pentobarbital in humans.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:1

    Topics: Adult; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Ethanol; Humans; Indomethacin; Male; Pentobarbital; Psychomotor Performance

1997

Other Studies

36 other study(ies) available for pentobarbital and indomethacin

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Stress-induced alterations of cyclic nucleotide levels in brain: effects of centrally acting drugs.
    Psychopharmacology, 1977, May-09, Volume: 52, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Brain; Brain Chemistry; Chlorpromazine; Clonidine; Cyclic AMP; Cyclic GMP; Diazepam; Diphenhydramine; Haloperidol; Indomethacin; Male; Mice; Pentobarbital; Phentolamine; Propanolamines; Propranolol; Reserpine; Stress, Physiological

1977
Studies on the mechanism of growth hormone and thyrotropin responses to somatostatin antiserum in anesthetized rats.
    Endocrinology, 1978, Volume: 103, Issue:5

    Topics: Anesthesia; Animals; Growth Hormone; Hypothalamus; Immune Sera; Indomethacin; Male; Pentobarbital; Prolactin; Rats; Somatostatin; Thyrotropin; Thyrotropin-Releasing Hormone; Urethane

1978
Prostaglandin synthetase inhibitors antagonize the depressant effects of ethanol.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:6

    Topics: Acetaminophen; Animals; Aspirin; Behavior, Animal; Butanols; Chloral Hydrate; Cyclooxygenase Inhibitors; Ethanol; Flufenamic Acid; Indomethacin; Male; Mefenamic Acid; Mice; Pentobarbital; Sleep

1979
Further observations on the effect of repeated electroconvulsive shock on the behavioural responses of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine.
    Psychopharmacology, 1977, Apr-29, Volume: 52, Issue:2

    Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Corpus Striatum; Cyclic AMP; Dopamine; Electroshock; Humans; Indomethacin; Male; Methamphetamine; Motor Activity; Pentobarbital; Rats; Serotonin; Sleep; Stereotyped Behavior; Substantia Nigra; Tranylcypromine; Tryptophan

1977
Effect of pentobarbital anesthesia and laparotomy on plasma renin activity in the dog.
    Canadian journal of physiology and pharmacology, 1979, Volume: 57, Issue:4

    Topics: Anesthesia; Animals; Blood Pressure; Dogs; Female; Heart Rate; Hemorrhage; Indomethacin; Laparotomy; Pentobarbital; Renin; Time Factors

1979
Mechanism for the increase in plasma renin activity by pentobarbital anesthesia.
    Life sciences, 1978, May-01, Volume: 22, Issue:17

    Topics: Anesthesia; Animals; Blood Pressure; Dogs; Female; Heart Rate; Indomethacin; Isoproterenol; Pentobarbital; Propranolol; Renin; Stimulation, Chemical

1978
Periovulatory changes in ovarian prostaglandin formation and their hormonal control in the rat.
    Prostaglandins, 1975, Volume: 9, Issue:5

    Topics: Animals; Depression, Chemical; Female; Follicle Stimulating Hormone; Indomethacin; Luteinizing Hormone; Mixed Function Oxygenases; Ovary; Ovulation; Pentobarbital; Pregnancy; Proestrus; Progesterone; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Prostaglandins F; Rats; Stimulation, Chemical

1975
The effect of indomethacin on renal function in pentobarbital-anesthetized dogs.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 198, Issue:2

    Topics: Aminohippuric Acids; Anesthesia; Animals; Blood Pressure; Dogs; Female; Glomerular Filtration Rate; Indomethacin; Kidney; Kidney Function Tests; Male; Pentobarbital; Potassium; Regional Blood Flow; Sodium

1976
Regional cerebral blood flow during spreading cortical depression in conscious rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1991, Volume: 11, Issue:1

    Topics: Animals; Blood Flow Velocity; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatum; Cortical Spreading Depression; Electric Stimulation; Frontal Lobe; Indomethacin; Male; Pentobarbital; Rats; Rats, Inbred Strains; Thalamus

1991
Pentobarbital augments pulmonary vasoconstrictor response to cyclooxygenase inhibition.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 2

    Topics: Animals; Blood Pressure; Carbon Dioxide; Cyclooxygenase Inhibitors; Dogs; Heart Rate; Hemodynamics; Indomethacin; Meclofenamic Acid; ortho-Aminobenzoates; Oxygen; Partial Pressure; Pentobarbital; Pulmonary Circulation; Vasoconstriction

1989
Cardiovascular responses to intravenous calcitonin gene-related peptide (CGRP) in the albino rabbit.
    Acta physiologica Scandinavica, 1989, Volume: 137, Issue:2

    Topics: Animals; Autonomic Nervous System; Blood Pressure; Calcitonin Gene-Related Peptide; Cardiac Output; Female; Hemodynamics; Hexamethonium; Hexamethonium Compounds; Indomethacin; Infusions, Intravenous; Male; Pentobarbital; Rabbits; Vascular Resistance; Vasodilation

1989
[Ethanol-induced discriminative stimulus properties in inbred rats with reference to aspirin, indomethacin and desipramine].
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1989, Volume: 24, Issue:6

    Topics: Animals; Aspirin; Desipramine; Discrimination, Psychological; Dose-Response Relationship, Drug; Indomethacin; Male; Pentobarbital; Rats; Rats, Inbred F344; Rats, Inbred Lew

1989
Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors.
    Japanese journal of pharmacology, 1988, Volume: 47, Issue:4

    Topics: Animals; Anticonvulsants; Atropine; beta-Alanine; Bicuculline; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Indomethacin; Male; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stomach Ulcer; Taurine

1988
The preovulatory increase in ovarian collagenase activity in the rat is independent of prostaglandin production.
    Endocrinology, 1986, Volume: 118, Issue:5

    Topics: Animals; Chorionic Gonadotropin; Female; Indomethacin; Luteinizing Hormone; Microbial Collagenase; Organ Size; Ovary; Ovulation; Pentobarbital; Prostaglandins E; Rats; Rats, Inbred Strains

1986
NADH fluorescence in vivo: changes in cerebral oxidative metabolism and perfusion induced by pentobarbital, indomethacin, and salicylate.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1987, Volume: 7, Issue:3

    Topics: Animals; Blood Volume; Brain; Fluorescence; Indomethacin; Male; NAD; Oxidation-Reduction; Pentobarbital; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid

1987
Organ tolerance of non-steroidal anti-inflammatory drugs: effect on liver cells.
    Drugs under experimental and clinical research, 1985, Volume: 11, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Benzoxazoles; Carbon Tetrachloride Poisoning; Indomethacin; Liver; Male; Mice; Pentobarbital; Propionates; Rats; Sulfobromophthalein; Transferases

1985
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
    Journal of neurosurgery, 1985, Volume: 62, Issue:6

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked Potentials, Somatosensory; Female; Indomethacin; Ketamine; Male; Pentobarbital

1985
Physiological role of prostaglandins in the induction of ovulation.
    Prostaglandins, 1972, Volume: 2, Issue:1

    Topics: Animals; Depression, Chemical; Estrus; Female; Indomethacin; Injections, Intraperitoneal; Luteinizing Hormone; Microscopy, Phase-Contrast; Ovarian Follicle; Ovary; Ovulation; Ovum; Pentobarbital; Pregnancy; Prostaglandins; Rats; Sodium; Stimulation, Chemical; Uterus

1972
Indomethacin-induced intestinal lesions in the rat.
    Toxicology and applied pharmacology, 1970, Volume: 17, Issue:3

    Topics: Administration, Oral; Animals; Antacids; Aspirin; Atropine; Bile Ducts; Bretylium Compounds; Chlorpromazine; Cholestyramine Resin; Cyproheptadine; Food Deprivation; Indomethacin; Injections, Subcutaneous; Intestinal Diseases; Intestinal Fistula; Intestinal Perforation; Intestine, Small; Male; Pentobarbital; Peptic Ulcer; Phenylbutazone; Rats; Scopolamine; Starvation; Time Factors

1970
Evidence implicating a prostaglandin as the mediator of intestinal fluid secretion induced by pithing: inhibition by indomethacin, morphine and pentobarbitone.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:7

    Topics: Animals; Body Fluids; Dinoprostone; Female; Indomethacin; Intestinal Mucosa; Intestines; Male; Morphine; Naloxone; Pentobarbital; Prostaglandins; Prostaglandins E; Rats; Spinal Cord

1982
Suppression of bradykinin-induced renin release by indomethacin in anesthetized rats.
    Clinical and experimental hypertension. Part A, Theory and practice, 1984, Volume: 6, Issue:6

    Topics: Anesthesia; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bradykinin; Heart Rate; Indomethacin; Male; Pentobarbital; Rats; Rats, Inbred Strains; Renin; Time Factors

1984
Cyclic response of hypophysectomized rats to ovulation induced by LHRH agonist: mediation by prostaglandins.
    Life sciences, 1984, Aug-27, Volume: 35, Issue:9

    Topics: Acetates; Adrenalectomy; Animals; Cyclooxygenase Inhibitors; Dinoprost; Estrus; Female; Gonadotropin-Releasing Hormone; Hypophysectomy; Indomethacin; Luteinizing Hormone; Median Eminence; Ovulation Induction; Pentobarbital; Pregnancy; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Thiazoles

1984
Prostaglandin synthetase inhibitors antagonize hypothermia induced by sedative hypnotics.
    Psychopharmacology, 1981, Volume: 74, Issue:3

    Topics: Body Temperature; Cyclooxygenase Inhibitors; Ethanol; Humans; Hypnotics and Sedatives; Indomethacin; Male; Pentobarbital; Postural Balance; Sleep; Time Factors

1981
The effect of prostaglandin synthesis inhibition of the acute blood pressure reduction by captopril in pentobarbital-anaesthetized rats.
    European journal of pharmacology, 1980, Aug-08, Volume: 65, Issue:4

    Topics: Anesthesia; Animals; Aspirin; Blood Pressure; Captopril; Drug Interactions; Heart Rate; Indomethacin; Male; Pentobarbital; Proline; Prostaglandins; Rats; Time Factors

1980
Influences of urethane anesthesia on indomethacin-induced gastric mucosal lesions in rats. Relation to blood glucose levels.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:12

    Topics: Anesthesia, General; Animals; Blood Glucose; Gastric Acid; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; Male; Pentobarbital; Prazosin; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Urethane; Yohimbine

1994
Pentobarbital-sensitive EDHF comediates ACh-induced arteriolar dilation in the hamster microcirculation.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: Acetylcholine; Adjuvants, Anesthesia; Animals; Arterioles; Biological Factors; Charybdotoxin; Cricetinae; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Fatty Acids, Unsaturated; Indomethacin; Mesocricetus; Microcirculation; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitroarginine; Penicillamine; Pentobarbital; Potassium; Potassium Channels; Skin; Vasodilator Agents

1999
Inhibition of GABA(A) receptor (GABAR) currents by arachidonic acid in HEK 293 cells stably transfected with alpha1beta2gamma2 GABAR subunits.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:3

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Anticonvulsants; Arachidonic Acid; Binding, Competitive; Cells, Cultured; Cyclooxygenase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Fatty Acids; Fatty Acids, Monounsaturated; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Indomethacin; Kidney; Linoleic Acid; Masoprocol; Membrane Potentials; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Transfection; Triazoles

2000
The formalin test in the mouse: a parametric analysis of scoring properties.
    Pain, 2000, Dec-15, Volume: 89, Issue:1

    Topics: Acepromazine; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Dipyrone; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Indomethacin; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Pain Measurement; Pentobarbital; Pimozide; Sensitivity and Specificity; Xylazine

2000
Thiamylal and pentobarbital have opposite effects on human platelet aggregation in vitro.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:5

    Topics: Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blood Platelets; Calcium; Fluorescent Dyes; Fura-2; Humans; Hypnotics and Sedatives; In Vitro Techniques; Indomethacin; Kinetics; Pentobarbital; Platelet Aggregation; Receptors, Thromboxane A2, Prostaglandin H2; Thiamylal

2003
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
    British journal of pharmacology, 2005, Volume: 146, Issue:3

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Brain; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Hindlimb; Indomethacin; Inflammation; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Phenylmethylsulfonyl Fluoride; Pyrazoles; Spinal Cord

2005