pentobarbital has been researched along with etomidate in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (31.67) | 18.7374 |
| 1990's | 13 (21.67) | 18.2507 |
| 2000's | 19 (31.67) | 29.6817 |
| 2010's | 9 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asproni, B; Biggio, G; Busonero, F; Cerri, R; Mascia, MP; Pau, A; Sanna, E; Sanna, S; Talani, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| France, CP; Lu, Y; Woods, JH | 1 |
| Ashton, D; Willems, R | 1 |
| Alsip, NL; Asher, EF; Harris, PD; Zhang, PY | 1 |
| Elias, E; Freeman, JF; Mills, CO; Salt, PJ | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Adams, RJ; Martin, DC; Nason, LA; Watkins, CA | 1 |
| Maksay, G; Nielsen, M; Simonyi, M | 1 |
| Dunwiddie, TV; Olsen, RW; Worth, TS | 1 |
| Dunwiddie, TV; Mynlieff, M; Proctor, WR | 1 |
| Djurhuus, JC; Kraglund, K; Stødkilde-Jørgensen, H; Sørensen, B | 1 |
| Green, CJ; Knight, J; Precious, S; Simpkin, S | 1 |
| Willow, M | 1 |
| Brenner, O; Quast, U | 1 |
| Ramanjaneyulu, R; Thyagarajan, R; Ticku, MK | 1 |
| Burch, TP; Ramanjaneyulu, R; Thyagarajan, R; Ticku, MK | 1 |
| Ashton, D | 1 |
| Braestrup, C; Honoré, T; Nielsen, M | 1 |
| Aschenbrenner, G; Blümel, G; Erhardt, W; Hebestedt, A; Pichotka, B | 1 |
| Clincke, G; Hermans, C; Melis, W; Van den Broeck, WA; VAn Loon, J; Wauquier, A | 1 |
| Ramanjaneyulu, R; Ticku, MK | 1 |
| Jonkman, J; Kalenda, Z; Tulleken, CA; van Dieren, A | 1 |
| Bleyaert, AL; Nemoto, EM; Shiu, GK | 1 |
| Aranda, M; Giannotta, SL; Levy, ML; Zelman, V | 1 |
| Fuchs, K; Sieghart, W; Slany, A; Zezula, J | 1 |
| Cestari, IN; Uchida, I; Yang, J | 1 |
| Mazerolles, M; Montastruc, JL; Montastruc, P; Senard, JM; Tran, MA; Verwaerde, P; Virenque, C | 1 |
| Belelli, D; Hill-Venning, C; Lambert, JJ; Peters, JA | 1 |
| Blissitt, KJ; Bradley, AA; Camburn, MA; Clutton, RE | 1 |
| Giannotta, SL; Lavine, SD; Levy, ML; Masri, LS | 1 |
| Belelli, D; Lambert, JJ; Peters, JA; Pistis, M | 2 |
| Fukami, S; Mashimo, T; Takenoshita, M; Uchida, I; Yoshiya, I | 1 |
| Carlson, BX; Engblom, AC; Kristiansen, U; Olsen, RW; Schousboe, A | 1 |
| Engelman, E; Gilbart, E; Schmartz, D; Van der Linden, P; Vincent, JL | 1 |
| Johnson, TE; Montoliu, L; Rikke, BA; Simpson, VJ | 1 |
| Lu, H; Xu, TL | 1 |
| Bonnert, TP; Cagetti, E; Thompson, SA; Wafford, KA; Whiting, PJ | 1 |
| Hemmings, HC; Pashkov, VN | 1 |
| Ho, SM; Waite, PM | 1 |
| Alva, H; Blednov, YA; Harris, RA; Jung, S; Rosahl, T; Wallace, D; Whiting, PJ | 1 |
| Chang, CS; Olcese, R; Olsen, RW | 1 |
| Hunter, J; Kienstra, AJ; Macias, CG; Morriss, MC; Sasan, F; Ward, MA | 1 |
| Brimelow, BC; Joksovic, PM; Murbartián, J; Perez-Reyes, E; Todorovic, SM | 1 |
| Asproni, B; Biggio, G; Busonero, F; Cerri, R; Maciocco, E; Mascia, MP; Pau, A; Sanna, E; Talani, G | 1 |
| Drafts, BC; Fisher, JL | 1 |
| Braun, HA; Raines, DE; Rüsch, D; Schuster, A; Wulf, H | 1 |
| Gage, PW; Luu, T; Tierney, ML | 1 |
| Baxter, AL; Cravero, J; Freilich, SH; Mallory, MD; Sharma, S; Spandorfer, PR | 1 |
| Patel, A; Szarlej, D; Wordell, C | 1 |
| Chumpitazi, CE; Macias, CG | 1 |
| Akk, G; Eaton, MM; Li, P; Steinbach, JH | 1 |
| Akk, G; Li, P | 1 |
| Baur, R; Maldifassi, MC; Sigel, E | 1 |
| Maldifassi, MC; Sigel, E | 1 |
| Czajkowski, C; Ghosh, B; Tsao, TW | 1 |
3 review(s) available for pentobarbital and etomidate
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Alternatives to sodium amobarbital in the Wada test.
Topics: Amobarbital; Anesthetics, Intravenous; Diagnostic Techniques, Neurological; Dominance, Cerebral; Etomidate; Humans; Methohexital; Neuropsychological Tests; Pentobarbital; Propofol | 2011 |
Sedation and anesthesia for CT: emerging issues for providing high-quality care.
Topics: Anesthesia; Child; Child, Preschool; Chloral Hydrate; Conscious Sedation; Etomidate; Humans; Hypnotics and Sedatives; Infant; Midazolam; Monitoring, Physiologic; Pediatrics; Pentobarbital; Risk Factors; Tomography, X-Ray Computed | 2011 |
2 trial(s) available for pentobarbital and etomidate
| Article | Year |
|---|---|
Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Anesthetics, Intravenous; Brain; Brain Edema; Drug Administration Schedule; Etomidate; Female; Hemodynamics; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intracranial Pressure; Male; Middle Aged; Pentobarbital; Pharmaceutical Vehicles; Propylene Glycol; Propylene Glycols | 1995 |
Etomidate versus pentobarbital for sedation of children for head and neck CT imaging.
Topics: Child; Child, Preschool; Consciousness Disorders; Double-Blind Method; Emergency Service, Hospital; Etomidate; Female; Head; Hospitals, Pediatric; Hospitals, Urban; Humans; Hypnotics and Sedatives; Infant; Male; Neck; Pentobarbital; Radiology Department, Hospital; Texas; Tomography, X-Ray Computed; Treatment Outcome; Vomiting | 2004 |
55 other study(ies) available for pentobarbital and etomidate
| Article | Year |
|---|---|
Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Brain; Female; GABA-A Receptor Agonists; Humans; Imidazoles; In Vitro Techniques; Male; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Reflex; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Tolerance to the cataleptic effect of the N-methyl-D-aspartate (NMDA) receptor antagonists in pigeons: cross-tolerance between PCP-like compounds and competitive NMDA antagonists.
Topics: Animals; Binding, Competitive; Columbidae; Dose-Response Relationship, Drug; Drug Tolerance; Etomidate; Eye; Hypnotics and Sedatives; Injections, Intramuscular; Muscle Relaxation; Pentobarbital; Phencyclidine; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate | 1992 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Pentobarbital; Phenobarbital; Triazoles | 1992 |
Prostaglandin-related microvascular dilation in pentobarbital- and etomidate-anesthetized rats.
Topics: Anesthesia, Intravenous; Animals; Etomidate; Male; Microcirculation; Muscles; Nitric Oxide; Pentobarbital; Prostaglandins; Rats; Rats, Inbred Strains; Serotonin; Vasodilation | 1992 |
Effect of anaesthetic agents on bile flow and biliary excretion of 131I-cholylglycyltyrosine in the rat.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Bile; Etomidate; Glycocholic Acid; Kinetics; Male; Pentobarbital; Phenols; Propofol; Rats; Rats, Inbred Strains | 1989 |
Characteristics of flunitrazepam binding to intact primary cultured spinal cord neurons and its modulation by GABAergic drugs.
Topics: Animals; Benzodiazepines; Binding, Competitive; Carbolines; Cells, Cultured; Embryo, Mammalian; Etazolate; Etomidate; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Muscimol; Neurons; Pentobarbital; Receptors, GABA-A; Spinal Cord | 1987 |
Anesthetic effects on 5-hydroxytryptamine uptake by rat brain synaptosomes.
Topics: Anesthetics; Animals; Brain Chemistry; Etomidate; Fentanyl; Ketamine; Pentobarbital; Rats; Rats, Inbred Strains; Serotonin; Sufentanil; Synaptosomes | 1988 |
The enhancement of diazepam and muscimol binding by pentobarbital and (+)-etomidate: size of the molecular arrangement estimated by electron irradiation inactivation of rat cortex.
Topics: Animals; Cerebral Cortex; Diazepam; Etomidate; gamma-Aminobutyric Acid; In Vitro Techniques; Molecular Weight; Muscimol; Pentobarbital; Rats; Receptors, GABA-A | 1986 |
Facilitation of recurrent inhibition in rat hippocampus by barbiturate and related nonbarbiturate depressant drugs.
Topics: Animals; Barbiturates; Central Nervous System Depressants; Etomidate; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Mephobarbital; Neural Inhibition; Pentobarbital; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1986 |
Facilitatory action of etomidate and pentobarbital on recurrent inhibition in rat hippocampal pyramidal neurons.
Topics: Action Potentials; Animals; Etomidate; gamma-Aminobutyric Acid; Hippocampus; Male; Neurons; Pentobarbital; Pyramidal Tracts; Rats; Rats, Inbred Strains; Synapses | 1986 |
Gastric acid secretion during halothane, chloralose, pentobarbital and etomidate anaesthesia in the pig.
Topics: Animals; Chloralose; Etomidate; Gastric Acid; Halothane; Imidazoles; Pentagastrin; Pentobarbital; Swine | 1985 |
Metomidate, etomidate and fentanyl as injectable anaesthetic agents in mice.
Topics: Anesthesia, General; Animals; Ethanol; Etomidate; Fentanyl; Imidazoles; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Pentobarbital | 1981 |
A comparison of the actions of pentobarbitone and etomidate on [3H]GABA binding to crude synaptosomal rat brain membranes.
Topics: Animals; Brain; Etomidate; gamma-Aminobutyric Acid; Imidazoles; Intracellular Membranes; Kinetics; Pentobarbital; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes | 1981 |
Modulation of [3H]muscimol binding in rat cerebellar and cerebral cortical membranes by picrotoxin, pentobarbitone, and etomidate.
Topics: Animals; Cell Membrane; Cerebellar Cortex; Cerebral Cortex; Etomidate; Imidazoles; Kinetics; Male; Muscimol; Organ Specificity; Oxazoles; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Enhancement of diazepam and gamma-aminobutyric acid binding by (+)etomidate and pentobarbital.
Topics: Animals; Cell Membrane; Cerebellum; Cerebral Cortex; Diazepam; Etomidate; gamma-Aminobutyric Acid; Imidazoles; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Barbiturate interactions with benzodiazepine-GABA receptor-ionophore complex.
Topics: Animals; Barbiturates; Etomidate; In Vitro Techniques; Ionophores; Muscimol; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Binding of 3H-DMCM to benzodiazepine receptors; chloride dependent allosteric regulation mechanisms.
Topics: Animals; Anions; Carbolines; Cerebral Cortex; Chlorides; Etomidate; Indoles; Molecular Conformation; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes | 1983 |
A comparative study with various anesthetics in mice (pentobarbitone, ketamine-xylazine, carfentanyl-etomidate).
Topics: Anesthesia, General; Anesthetics; Animals; Cardiovascular System; Etomidate; Fentanyl; Ketamine; Male; Mice; Mice, Inbred BALB C; Pentobarbital; Respiration; Xylazine | 1984 |
Global incomplete ischemia in dogs assessed by quantitative EEG analysis. Effects of hypnotics and flunarizine.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Calcium Channel Blockers; Cinnarizine; Computers; Dogs; Electroencephalography; Etomidate; Female; Flunarizine; Imidazoles; Male; Pentobarbital; Piperazines; Thiopental | 1984 |
Binding characteristics and interactions of depressant drugs with [35S]t-butylbicyclophosphorothionate, a ligand that binds to the picrotoxinin site.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Convulsants; Diazepam; Etomidate; gamma-Aminobutyric Acid; Male; Membranes; Pentobarbital; Picrotoxin; Psychotropic Drugs; Rats; Rats, Inbred Strains; Sesterterpenes | 1984 |
Clinical and experimental experience with etomidate as a brain protective agent.
Topics: Animals; Blood Pressure; Brain; Cats; Cerebrovascular Circulation; Cerebrovascular Disorders; Etomidate; Humans; Imidazoles; Macaca mulatta; Models, Biological; Pentobarbital | 1982 |
Efficacy of therapies and attenuation of brain free fatty acid liberation during global ischemia.
Topics: Animals; Brain; Brain Ischemia; Etomidate; Fatty Acids, Nonesterified; Female; Halothane; Hypothermia, Induced; Pentobarbital; Rats | 1981 |
Allosteric modulation of [3H]flunitrazepam binding to recombinant GABAA receptors.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Cell Line; Cerebellum; Dose-Response Relationship, Drug; Etomidate; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kidney; Pentobarbital; Radioligand Assay; Rats; Receptors, GABA-A | 1995 |
The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons.
Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Bicuculline; Binding Sites; Cells, Cultured; Chloride Channels; Chlorides; Etomidate; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Models, Molecular; Neurons; Pentobarbital; Pyridazines; Rats; Receptors, GABA-A | 1996 |
Effects of pentobarbital and etomidate on plasma catecholamine levels and spectral analysis of blood pressure and heart rate in dogs.
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Blood Pressure; Catecholamines; Dogs; Etomidate; Fourier Analysis; Heart Rate; Pentobarbital; Signal Processing, Computer-Assisted | 1996 |
Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor.
Topics: Anesthetics, Intravenous; Animals; Etomidate; Humans; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis | 1997 |
Comparison of three injectable anaesthetic techniques in pigs.
Topics: Adjuvants, Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Azaperone; Etomidate; Female; Infusions, Intravenous; Injections, Intramuscular; Ketamine; Laparoscopy; Midazolam; Pentobarbital; Swine | 1997 |
Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Aneurysm, Ruptured; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Cerebrovascular Circulation; Constriction; Electroencephalography; Etomidate; Female; Humans; Iatrogenic Disease; Intracranial Aneurysm; Ischemic Attack, Transient; Isoflurane; Male; Microsurgery; Middle Aged; Neuroprotective Agents; Pentobarbital; Propofol; Radiography; Retrospective Studies; Risk Factors; Subarachnoid Hemorrhage; Time Factors | 1997 |
The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study.
Topics: Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Etomidate; GABA Modulators; Humans; Oocytes; Pentobarbital; Propofol; Rats; Receptors, GABA-A; Receptors, Glycine; Xenopus laevis | 1997 |
The effects of a point mutation of the beta2 subunit of GABA(A) receptor on direct and modulatory actions of general anesthetics.
Topics: Amino Acid Substitution; Anesthetics, General; Animals; Chloride Channels; Dose-Response Relationship, Drug; Etomidate; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Membrane Potentials; Mice; Oocytes; Pentobarbital; Phenylalanine; Point Mutation; Propofol; Receptors, GABA-A; Tyrosine; Xenopus laevis | 1999 |
The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors.
Topics: Anesthetics; Animals; Drug Interactions; Electric Conductivity; Etomidate; Female; gamma-Aminobutyric Acid; Glycine; Mutagenesis, Site-Directed; Oocytes; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Receptors, Glycine; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 1999 |
A single glycine residue at the entrance to the first membrane-spanning domain of the gamma-aminobutyric acid type A receptor beta(2) subunit affects allosteric sensitivity to GABA and anesthetics.
Topics: Allosteric Regulation; Amino Acid Sequence; Anesthetics; Animals; Cells, Cultured; Chloride Channels; Electrophysiology; Etomidate; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Pentobarbital; Pregnanediones; Propofol; Protein Conformation; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Sequence Homology, Amino Acid; Spodoptera | 2000 |
Effects of propofol, etomidate, and pentobarbital on critical oxygen delivery.
Topics: Anesthetics, Intravenous; Animals; Dogs; Dose-Response Relationship, Drug; Etomidate; Female; Hemodynamics; Lactates; Male; Oxygen Consumption; Pentobarbital; Propofol | 2000 |
No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics.
Topics: Albinism; Anesthetics; Animals; Crosses, Genetic; Ethanol; Etomidate; Female; Hypnotics and Sedatives; Isoflurane; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Pentobarbital; Postural Balance; Reflex | 2001 |
The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons.
Topics: Anesthetics, General; Animals; Etomidate; Neural Inhibition; Pentobarbital; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Taurine | 2002 |
Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics.
Topics: Anesthetics; Anesthetics, Intravenous; Animals; Blotting, Western; Cell Line; Cloning, Molecular; DNA, Complementary; Etomidate; Female; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Humans; Oocytes; Pentobarbital; Picrotoxin; Protein Engineering; Receptors, GABA-A; Steroids; Transfection; Xenopus laevis | 2002 |
The effects of general anesthetics on norepinephrine release from isolated rat cortical nerve terminals.
Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cerebral Cortex; Egtazic Acid; Etomidate; Halothane; In Vitro Techniques; Ketamine; Nerve Endings; Norepinephrine; Pentobarbital; Potassium Chloride; Propofol; Rats; Receptors, Presynaptic; Synaptic Transmission; Synaptosomes | 2002 |
Effects of different anesthetics on the paired-pulse depression of the h reflex in adult rat.
Topics: Administration, Inhalation; Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Etomidate; H-Reflex; Halothane; Heart Rate; Ketamine; Pentobarbital; Rats; Rats, Wistar; Respiration; Sensory Thresholds; Spinal Cord Injuries | 2002 |
Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System Depressants; Chlorides; Ethanol; Etomidate; Female; Flurazepam; GABA Agonists; GABA Modulators; Gene Deletion; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Mice, Knockout; Pentobarbital; Postural Balance; Pyridines; Receptors, GABA; Receptors, GABA-A; Sex Characteristics; Sleep; Time Factors; Zolpidem | 2003 |
A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation.
Topics: Adjuvants, Anesthesia; Allosteric Site; Amino Acid Sequence; Anesthetics; Anesthetics, Intravenous; Animals; Cloning, Molecular; DNA Mutational Analysis; Dose-Response Relationship, Drug; Etomidate; Kinetics; Ligands; Models, Biological; Molecular Sequence Data; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Propofol; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Xenopus | 2003 |
Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels.
Topics: Anesthetics, General; Barbiturates; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line; Dose-Response Relationship, Drug; Enflurane; Ethanol; Etomidate; Humans; Inhibitory Concentration 50; Isoflurane; Kinetics; Neurons, Afferent; Nitrous Oxide; Patch-Clamp Techniques; Pentobarbital; Propofol; Recombinant Proteins; Thalamus | 2005 |
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Etomidate; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Humans; Hydrocarbons, Halogenated; Imidazoles; Male; Membrane Potentials; Oocytes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, Serotonin, 5-HT3; Serotonin; Tritium; Xenopus laevis | 2005 |
Identification of structures within GABAA receptor alpha subunits that regulate the agonist action of pentobarbital.
Topics: Allosteric Regulation; Animals; Cell Line; Etomidate; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Mice; Pentobarbital; Protein Subunits; Receptors, GABA-A; Structure-Activity Relationship | 2006 |
Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital.
Topics: Animals; Dose-Response Relationship, Drug; Electrophysiology; Etomidate; Female; Humans; Hypnotics and Sedatives; Membrane Potentials; Microinjections; Oocytes; Pentobarbital; Propofol; Protein Isoforms; Receptors, Serotonin, 5-HT3; RNA; Xenopus laevis | 2007 |
Functional asymmetry of the conserved cystine loops in alphabetagamma GABA A receptors revealed by the response to GABA activation and drug potentiation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cystine; Diazepam; Drug Synergism; Etomidate; GABA Modulators; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Molecular Sequence Data; Patch-Clamp Techniques; Pentobarbital; Proline; Protein Conformation; Receptors, GABA-A; Receptors, GABA-B | 2008 |
Etomidate versus pentobarbital for computed tomography sedations: report from the Pediatric Sedation Research Consortium.
Topics: Age Factors; Child, Preschool; Cohort Studies; Conscious Sedation; Etomidate; Humans; Hypnotics and Sedatives; Infant; Outcome and Process Assessment, Health Care; Pentobarbital; Retrospective Studies; Tomography, X-Ray Computed; Treatment Outcome | 2007 |
The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.
Topics: Anesthetics; Animals; Binding Sites; Diazepam; Drug Synergism; Etomidate; GABA Modulators; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Patch-Clamp Techniques; Pentobarbital; Pregnanediones; Rats; Receptors, GABA-A | 2013 |
Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs.
Topics: Anesthetics; Animals; Cell Line; Chromosome Pairing; Etomidate; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Pentobarbital; Pregnanediones; Propofol; Rats; Receptors, GABA-A | 2015 |
Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital.
Topics: Anesthetics, Intravenous; Animals; Binding Sites; Electrophysiological Phenomena; Etomidate; Mutation; Oocytes; Pentobarbital; Propofol; Rats; Receptors, GABA-A; Xenopus | 2016 |
Functional sites for anesthetics in GABAA receptors.
Topics: Allosteric Site; Anesthetics; Animals; Binding Sites; DNA Mutational Analysis; Etomidate; Humans; Ions; Mutation; Neurotransmitter Agents; Oocytes; Pentobarbital; Propofol; Protein Domains; Protein Isoforms; Receptors, GABA-A; Xenopus | 2017 |
A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation.
Topics: Animals; Bacterial Proteins; Cell Membrane; Chlorides; Etomidate; Extracellular Space; gamma-Aminobutyric Acid; Humans; Ligand-Gated Ion Channels; Membrane Potentials; Mutation; Neurotransmitter Agents; Oocytes; Pentobarbital; Picrotoxin; Propofol; Protein Domains; Protons; Receptors, GABA-B; Recombinant Fusion Proteins; Xenopus laevis | 2017 |