pentamidine and pafuramidine

pentamidine has been researched along with pafuramidine in 16 studies

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (50.00)	29.6817
2010's	8 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Boykin, DW; Brun, R; Easterbrook, JD; Ismail, MA; Tanious, FA; Wilson, WD	1
Boykin, DW; Brun, R; Ismail, MA; Tanious, FA; Wenzler, T; Wilson, WD	1
Arafa, RK; Boykin, DW; Bridges, A; Brun, R; Generaux, C; Hall, JE; Ismail, MA; Miao, Y; Wenzler, T; Wilson, WD	1
Boykin, DW; Hall, JE; Jones, SK; Rahmathullah, SM; Tidwell, RR	1
Boykin, DW; Brun, R; Hall, JE; Ismail, MA; Tidwell, RR; Wenzler, T	1
Bakunov, SA; Bakunova, SM; Brun, R; Ghebru, M; Tidwell, RR; Wenzler, T; Werbovetz, KA	1
Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD	1
Bondada, L; Boykin, DW; Brun, R; Hu, L; Munde, M; Patel, A; Wang, MZ; Wenzler, T; Wilson, WD; Yang, S	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Werbovetz, K	1
Brun, R; Kagira, JM; Karanja, SM; Mdachi, RE; Ngotho, JM; Thuita, JK; Tidwell, R; Wenzler, T	1
Brun, R; Hall, JE; Kagira, JM; Mdachi, RE; Murilla, GA; Ndung'u, JM; Ngotho, JM; Thuita, JK; Tidwell, RR	1
Generaux, CN; Goldsmith, RB; Gray, DR; Reisner, HM; Tidwell, RR; Yan, Z	1
Barrett, MP; Boykin, DW; Brun, R; Burri, C; De Koning, HP; Generaux, CN; Murilla, GA; Olson, CA; Paine, MF; Pohlig, G; Thuita, JK; Tidwell, RR; Wang, MZ; Wilson, WD	1
Allen, JL; Bernhard, SC; Bilenge, CM; Blum, J; Burri, C; Josenando, T; Lubaki, JP; Lutumba, P; Manuel, F; Merolle, A; Mesu, VK; Mpanya, A; Mpoto, AM; Munungu, BF; Olson, CA; Pohlig, G; Serge, KK; Thompson, M; Tidwell, RR; Yeramian, PD	1
Bernhard, SC; Bilenge, CM; Blum, J; Burri, C; Dala, A; Deo, GK; Dituvanga, ND; Franco, JR; Kuikumbi, FM; Lubaki, JP; Macharia, S; Mesu, VK; Mintwo, AF; Mpanya, A; Mpoto, AM; Munungi, AK; Munungu, BF; Mutantu, PN; N'tombe, PM; Olson, CA; Pohlig, G; Tidwell, RR	1

Reviews

3 review(s) available for pentamidine and pafuramidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. Current opinion in investigational drugs (London, England : 2000), 2006, Volume: 7, Issue:2 Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Leishmania; Leishmaniasis; Malaria, Falciparum; Pentamidine; Plasmodium falciparum; Prodrugs; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma cruzi; Trypanosomiasis, African	2006
Diamidines for human African trypanosomiasis. Current opinion in investigational drugs (London, England : 2000), 2010, Volume: 11, Issue:8 Topics: Animals; Benzamidines; Biotransformation; Brain; Clinical Trials as Topic; Drug Design; Drug Resistance; Humans; Pentamidine; Prodrugs; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2010

Trials

2 trial(s) available for pentamidine and pafuramidine

Article	Year
Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies. PLoS neglected tropical diseases, 2016, Volume: 10, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Angola; Antiprotozoal Agents; Benzamidines; Democratic Republic of the Congo; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Pentamidine; Treatment Outcome; Trypanosomiasis, African; Young Adult	2016
Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. PLoS neglected tropical diseases, 2016, Volume: 10, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Angola; Benzamidines; Child; Democratic Republic of the Congo; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Injections, Intramuscular; Kidney Diseases; Male; Middle Aged; Pentamidine; Pregnancy; Sudan; Treatment Outcome; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult	2016

Article

Year

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies.

PLoS neglected tropical diseases, 2016, Volume: 10, Issue:2

Topics: Administration, Oral; Adolescent; Adult; Angola; Antiprotozoal Agents; Benzamidines; Democratic Republic of the Congo; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Pentamidine; Treatment Outcome; Trypanosomiasis, African; Young Adult

2016

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.

PLoS neglected tropical diseases, 2016, Volume: 10, Issue:2

Topics: Administration, Oral; Adolescent; Adult; Aged; Angola; Benzamidines; Child; Democratic Republic of the Congo; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Injections, Intramuscular; Kidney Diseases; Male; Middle Aged; Pentamidine; Pregnancy; Sudan; Treatment Outcome; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult

2016

Other Studies

11 other study(ies) available for pentamidine and pafuramidine

Article	Year
Synthesis and antiprotozoal activity of aza-analogues of furamidine. Journal of medicinal chemistry, 2003, Oct-23, Volume: 46, Issue:22 Topics: Animals; Antimalarials; Antiprotozoal Agents; Aza Compounds; Benzamidines; Mice; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2003
Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents. Journal of medicinal chemistry, 2004, Jul-01, Volume: 47, Issue:14 Topics: Animals; Antimalarials; Antiprotozoal Agents; Imidazoles; Mice; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense	2004
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues. Journal of medicinal chemistry, 2006, Aug-24, Volume: 49, Issue:17 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Biotransformation; Cations; DNA; Drug Stability; In Vitro Techniques; Liver; Mice; Microsomes; Molecular Structure; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Terphenyl Compounds; Trypanosoma brucei rhodesiense	2006
Carbamate prodrugs of N-alkylfuramidines. European journal of medicinal chemistry, 2008, Volume: 43, Issue:1 Topics: Animals; Benzamidines; Carbamates; Cysts; Disease Models, Animal; Furans; Lung; Pneumocystis carinii; Pneumonia, Pneumocystis; Prodrugs; Rats	2008
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10 Topics: Animals; Benzamidines; Central Nervous System; Female; Furans; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2009
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Amidines; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Disease Models, Animal; Female; Leishmania donovani; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Stereoisomerism; Structure-Activity Relationship; Triazoles; Trypanosoma brucei rhodesiense	2010
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. Bioorganic & medicinal chemistry, 2010, May-15, Volume: 18, Issue:10 Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Protozoan; Drug Stability; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorganic & medicinal chemistry, 2013, Nov-01, Volume: 21, Issue:21 Topics: Animals; Antiprotozoal Agents; Aza Compounds; Cations; Cell Line; Cell Survival; Disease Models, Animal; Mice; Myoblasts; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Poly dA-dT; Prodrugs; Pyrazines; Rats; Structure-Activity Relationship; Transition Temperature; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2013
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis. Acta tropica, 2008, Volume: 108, Issue:1 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Benzamidines; Female; Humans; Mice; Molecular Structure; Pentamidine; Prodrugs; Trypanosoma brucei gambiense; Trypanosomiasis, African	2008
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3 Topics: Administration, Oral; Animals; Benzamidines; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Pentamidine; Prodrugs; Random Allocation; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2009
Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo. Journal of clinical laboratory analysis, 2010, Volume: 24, Issue:3 Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Benzamidines; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Hepatocytes; Humans; Immunoglobulin G; Male; Mice; Mice, Inbred BALB C; Pentamidine; Prodrugs; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tandem Mass Spectrometry; Trypanocidal Agents; Trypanosomiasis, African	2010