Page last updated: 2024-08-23

pentamethylmelamine and altretamine

pentamethylmelamine has been researched along with altretamine in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (95.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (2.50)	29.6817
2010's	1 (2.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Ames, MM; Eagan, RT; Kovach, JS; Powis, G	1
Ames, MM; Powis, G	1
Narasimhan, TR; Riley, C; Slavik, J; Slavik, M	1
Borm, PJ; Frankhuyzen-Sierevogel, AC; Noordhoek, J; Weller, EB	1
Clagett-Carr, K; Foster, BJ; Hoth, D; Leyland-Jones, B	1
Abel, G; Graham, MA; Judson, IR; Rutty, CJ	1
Abel, G; Goddard, PM; Harrap, KR; Judson, IR; Newell, DR; Rutty, CJ	1
Abikhalil, F; Atassi, G; Dubois, J; Hanocq, M	2
Hofman, GA; Hulshoff, A; Klippert, PJ; Noordhoek, J	1
Harrap, KR; Muindi, JR; Newell, DR; Smith, IE	1
Hofman, G; Hulshoff, A; Klippert, PJ; Mingels, MJ; Noordhoek, J	1
Hahn, DA	1
Bianchi, M; Catalani, P; Colombo, T; D'Incalci, M; Donelli, MG; Garattini, E; Pantarotto, C	1
Gescher, A; Langdon, SP; Ross, D; Stevens, MF	1
Elserafi, M; Gad-el-Mawla, N; Hamza, R; Khaled, H; Ziegler, JL	1
Broggini, M; Coccia, P; Colombo, T; D'Incalci, M; Garattini, E; Rossi, C	1
Benjamin, RS; Benvenuto, JA; Cabanillas, F; Leavens, M; Loo, TL; Smith, RG; Stewart, DJ	1
Achilli, G; Broggini, M; D'Incalci, M; Garattini, S; Lipartiti, M; Perego, C; Ponzio, F	1
Carter, SK	1
Abel, G; Rutty, CJ	1
Boyd, MR; Dutcher, JS; Jones, RB	1
Goldin, A; Green, D; Morimoto, M; Rahman, A; Schein, PS	1
Begleiter, A; Goldenberg, GJ; Grover, J	1
Benjamin, RS; Benvenuto, JA; Loo, TL; Stewart, DJ	1
Goldberg, RS; Griffin, JP; Krakoff, IH; McSherry, JW	1
Aisner, J; Chiuten, DF; Lichtenfeld, JL; Van Echo, DA; Whitacre, M; Wiernik, PH	1
Casper, ES; Gordon, C; Gralla, RJ; Jones, BR; Kelsen, DP; Lynch, GR; Woodcock, TM; Young, CW	1
Benjamin, RS; Benvenuto, JA; Loo, TL; Smith, RG; Stewart, DJ	1
McMillan, DR; Ross, CF; Ross, WE	1
Gescher, A; Raymont, C	1
Colombo, T; D'Incalci, M; Torti, L	1
Ames, MM; Sanders, ME; Tiede, WS	1
Broggini, M; Colombo, T; D'Incalci, M; Rossi, C	1
Ajani, JA; Bodey, GP; Cabanillas, FF	1
Harrap, KR; Muindi, JR; Newell, DR; Rutty, CJ	1
Casper, ES; Deesen, PE; Leyland-Jones, BR; Young, CW	1
Broggini, M; Colombo, T; D'Incalci, M; Gescher, A	1

Reviews

2 review(s) available for pentamethylmelamine and altretamine

Article	Year
Pentamethylmelamine: review of an aqueous analog of hexamethylmelamine. Cancer treatment reports, 1986, Volume: 70, Issue:3 Topics: Altretamine; Animals; Antineoplastic Agents; Clinical Trials as Topic; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Haplorhini; Humans; Kinetics; Mice; Neoplasms; Structure-Activity Relationship; Triazines	1986
New cytotoxic drugs for breast cancer and their clinical evaluation. European journal of cancer, 1980, Volume: Suppl 1 Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Daunorubicin; Doxorubicin; Female; Gallium; Humans; Ifosfamide; Leukemia; Vinblastine; Vindesine; Zinostatin	1980

Trials

4 trial(s) available for pentamethylmelamine and altretamine

Article	Year
Pentamethylmelamine: review of an aqueous analog of hexamethylmelamine. Cancer treatment reports, 1986, Volume: 70, Issue:3 Topics: Altretamine; Animals; Antineoplastic Agents; Clinical Trials as Topic; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Haplorhini; Humans; Kinetics; Mice; Neoplasms; Structure-Activity Relationship; Triazines	1986
Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies. British journal of cancer, 1983, Volume: 47, Issue:1 Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Clinical Trials as Topic; Female; Humans; Kinetics; Liver; Liver Neoplasms; Male; Middle Aged; Nausea; Neoplasms; Nervous System Diseases; Triazines; Vomiting	1983
Randomized phase II trial of hexamethylmelamine versus pentamethylmelamine in carcinoma of the bilharzial bladder. Cancer treatment reports, 1984, Volume: 68, Issue:5 Topics: Altretamine; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Humans; Nausea; Random Allocation; Schistosomiasis; Time Factors; Triazines; Urinary Bladder Neoplasms	1984
New cytotoxic drugs for breast cancer and their clinical evaluation. European journal of cancer, 1980, Volume: Suppl 1 Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Daunorubicin; Doxorubicin; Female; Gallium; Humans; Ifosfamide; Leukemia; Vinblastine; Vindesine; Zinostatin	1980

Other Studies

36 other study(ies) available for pentamethylmelamine and altretamine

Article	Year
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Disposition and metabolism of pentamethylmelamine and hexamethylmelamine in rabbits and humans. Cancer research, 1979, Volume: 39, Issue:12 Topics: Altretamine; Animals; Biological Availability; Drug Evaluation; Humans; Intestinal Absorption; Liver; Male; Neoplasms; Rabbits; Time Factors; Triazines	1979
Determination of pentamethylmelamine and hexamethylmelamine in plasma and urine by nitrogen-phosphorus gas-liquid chromatography. Journal of chromatography, 1979, Jun-01, Volume: 174, Issue:1 Topics: Altretamine; Antineoplastic Agents; Chromatography, Gas; Humans; Nitrogen; Phosphorus; Triazines	1979
Changes in serum copper and zinc during treatment with anticancer drugs interfering with pyridoxal phosphate. Advances in experimental medicine and biology, 1989, Volume: 258 Topics: Altretamine; Animals; Antineoplastic Agents; Coenzymes; Copper; Male; Procarbazine; Pyridoxal Phosphate; Rabbits; Triazines; Zinc	1989
Absorption and metabolism of hexamethylmelamine and pentamethylmelamine in rat everted perfused gut segments: correlation with in-vivo data. The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:9 Topics: Altretamine; Animals; Antineoplastic Agents; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Kinetics; Male; Muscle, Smooth; Rats; Rats, Inbred Strains; Subcellular Fractions; Triazines	1985
Low central nervous system penetration of N2,N4,N6,-trihydroxymethyl-N2,N4,N6,-trimethylmelamine (Trimelamol): a cytotoxic s-triazine with reduced neurotoxicity. British journal of cancer, 1986, Volume: 53, Issue:5 Topics: Altretamine; Animals; Blood Proteins; Blood-Brain Barrier; Brain; Kinetics; Male; Mice; Mice, Inbred BALB C; Protein Binding; Triazines	1986
Preclinical toxicology, pharmacokinetics and formulation of N2,N4,N6-trihydroxymethyl-N2,N4,N6-trimethylmelamine (trimelamol), a water-soluble cytotoxic s-triazine which does not require metabolic activation. Cancer chemotherapy and pharmacology, 1986, Volume: 17, Issue:3 Topics: Altretamine; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Kinetics; Male; Mice; Mice, Inbred BALB C; Plasmacytoma; Rats; Rats, Inbred Strains; Solubility; Triazines	1986
Pharmacokinetics and metabolism of hexamethylmelamine in mice after IP administration. Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:3 Topics: Algorithms; Altretamine; Animals; Chemical Phenomena; Chemistry; Half-Life; Injections, Intraperitoneal; Kinetics; Male; Mice; Models, Biological; Triazines	1986
Pharmacokinetics and metabolism of hexamethylmelamine in mice bearing renal cell tumors. Cancer chemotherapy and pharmacology, 1988, Volume: 22, Issue:4 Topics: Altretamine; Animals; Biological Availability; Carcinoma, Renal Cell; Kidney Neoplasms; Male; Mathematics; Mice; Triazines	1988
First-pass metabolism of pentamethylmelamine in the rat liver. Cancer research, 1985, Volume: 45, Issue:3 Topics: Altretamine; Animals; Antineoplastic Agents; Biological Availability; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Triazines	1985
Low oral bioavailability of hexamethylmelamine in the rat due to simultaneous hepatic and intestinal metabolism. Cancer research, 1983, Volume: 43, Issue:7 Topics: Altretamine; Animals; Biological Availability; Chromatography, Gas; Injections, Intra-Arterial; Injections, Intravenous; Intestinal Absorption; Intestine, Small; Intubation, Gastrointestinal; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Triazines	1983
Hexamethylmelamine and pentamethylmelamine: an update. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:6 Topics: Altretamine; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans; Leukemia; Lung Neoplasms; Male; Ovarian Neoplasms; Prostatic Neoplasms; Triazines	1983
Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma. Cancer chemotherapy and pharmacology, 1983, Volume: 11, Issue:1 Topics: Altretamine; Animals; Antineoplastic Agents; Female; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Tissue Distribution; Triazines	1983
Studies of the mode of action of antitumour triazenes and triazines-V. The correlation of the in vitro cytotoxicity and in vivo antitumour activity of hexamethylmelamine analogues with their metabolism. Biochemical pharmacology, 1984, Apr-01, Volume: 33, Issue:7 Topics: Altretamine; Animals; Antineoplastic Agents; Biotransformation; Cell Line; Dealkylation; Female; Formaldehyde; Male; Mice; Mice, Inbred Strains; Triazines	1984
Biochemical studies on the ability of pentamethylmelamine to interact in vivo with DNA and proteins in a sensitive murine ovarian reticular cell sarcoma. Biochemical pharmacology, 1984, Sep-01, Volume: 33, Issue:17 Topics: Altretamine; Animals; Antineoplastic Agents; DNA, Neoplasm; Female; Liver; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Ovarian Neoplasms; Protein Binding; Triazines	1984
Human central nervous system pharmacology of pentamethylmelamine and its metabolites. Journal of neuro-oncology, 1983, Volume: 1, Issue:4 Topics: Altretamine; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Glioma; Humans; Kinetics; Melanoma; Triazines	1983
Central side effects of pentamethylmelamine: biochemical and behavioural studies. Biochemical pharmacology, 1984, Dec-15, Volume: 33, Issue:24 Topics: Altretamine; Animals; Biogenic Amines; Body Temperature; Brain; Dopamine; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Motor Activity; Receptors, Dopamine; Spiperone; Triazines	1984
In vitro cytotoxicity of the methylmelamines. Chemico-biological interactions, 1980, Volume: 29, Issue:2 Topics: Altretamine; Animals; Cell Survival; Cells, Cultured; Formaldehyde; Mice; Neoplasms, Experimental; Semicarbazides; Triazines	1980
A sensitive and specific assay for pentamethylmelamine in plasma: applicability to clinical studies. Cancer treatment reports, 1980, Volume: 64, Issue:1 Topics: Aged; Altretamine; Antineoplastic Agents; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Male; Middle Aged; Neoplasms; Reference Standards; Triazines	1980
Comparative pharmacology of pentamethylmelamine and hexamethylmelamine in mice. Cancer research, 1980, Volume: 40, Issue:8 Pt 1 Topics: Alkylating Agents; Altretamine; Animals; DNA Replication; DNA, Neoplasm; Leukocyte Count; Male; Mice; Microsomes, Liver; Neoplasms, Experimental; Plasmacytoma; RNA, Neoplasm; Triazines	1980
Uptake and metabolism of hexamethylmelamine and pentamethylmelamine by L5178Y lymphoblasts in vitro. Cancer research, 1980, Volume: 40, Issue:12 Topics: Altretamine; Animals; Antineoplastic Agents; Biological Transport; Cell Membrane Permeability; Free Radicals; Kinetics; Leukemia, Experimental; Lymphocytes; Methylation; Mice; Structure-Activity Relationship; Temperature; Triazines	1980
Pharmacology of pentamethylmelamine in humans. Cancer research, 1981, Volume: 41, Issue:2 Topics: Altretamine; Biotransformation; Central Nervous System; Humans; Liver; Liver Diseases; Metabolic Clearance Rate; Triazines	1981
Phase I study of pentamethylmelamine. Cancer treatment reports, 1980, Volume: 64, Issue:12 Topics: Adult; Altretamine; Dose-Response Relationship, Drug; Drug Evaluation; Electroencephalography; Humans; Injections, Intravenous; Leukocyte Count; Myeloproliferative Disorders; Nausea; Neoplasms; Platelet Count; Psychoses, Substance-Induced; Triazines; Vomiting	1980
Phase I trial of pentamethylmelamine in patients with previously treated malignancies. Cancer treatment reports, 1980, Volume: 64, Issue:12 Topics: Adult; Aged; Altretamine; Anorexia; Central Nervous System; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Middle Aged; Nausea; Neoplasms; Triazines; Vomiting	1980
Phase I and pharmacological studies of pentamethylmelamine administered by 24-hour intravenous infusion. Cancer research, 1981, Volume: 41, Issue:4 Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusions, Parenteral; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Nausea; Prognosis; Triazines; Vomiting	1981
High-performance liquid chromatographic analysis of pentamethylmelamine and its metabolites in biological fluids. Journal of chromatography, 1981, Mar-13, Volume: 222, Issue:3 Topics: Altretamine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Kinetics; Metabolic Clearance Rate; Neoplasms; Structure-Activity Relationship; Triazines	1981
Comparison of DNA damage by methylmelamines and formaldehyde. Journal of the National Cancer Institute, 1981, Volume: 67, Issue:1 Topics: Altretamine; Animals; Cells, Cultured; DNA, Neoplasm; Formaldehyde; Leukemia L1210; Mice; Semicarbazides; Triazines	1981
Studies of the metabolism of N-methyl containing anti-tumour agents: 14CO2 breath analysis after administration of 14C-labelled N-methyl drugs, formaldehyde and formate in mice. Biochemical pharmacology, 1981, Jun-01, Volume: 30, Issue:11 Topics: Altretamine; Aminopyrine; Animals; Antineoplastic Agents; Biotransformation; Caffeine; Carbon Dioxide; Formaldehyde; Formates; Male; Mice; Mice, Inbred CBA; Procarbazine	1981
Dose-dependent pharmacokinetics of PMM in the rat. Cancer chemotherapy and pharmacology, 1981, Volume: 5, Issue:3 Topics: Altretamine; Animals; Biotransformation; Kinetics; Male; Rats; Triazines	1981
Metabolic activation of hexamethylmelamine and pentamethylmelamine by liver microsomal preparations. Life sciences, 1981, Oct-12, Volume: 29, Issue:15 Topics: Altretamine; Animals; Antineoplastic Agents; Biotransformation; Glutathione; In Vitro Techniques; Male; Microsomes, Liver; NADP; Protein Binding; Rats; Rats, Inbred Strains; Time Factors; Triazines	1981
Hexamethylmelamine and pentamethylmelamine tissue distribution in M5076/73A ovarian cancer-bearing mice. Cancer treatment reports, 1982, Volume: 66, Issue:1 Topics: Altretamine; Animals; Antineoplastic Agents; Female; Kinetics; Mice; Neoplasms, Experimental; Ovarian Neoplasms; Tissue Distribution; Triazines	1982
Phase I trial of pentamethylmelamine. Cancer treatment reports, 1982, Volume: 66, Issue:5 Topics: Altretamine; Antineoplastic Agents; Bone Marrow; Central Nervous System; Drug Evaluation; Humans; Neoplasms; Triazines	1982
The comparative pharmacokinetics of pentamethylmelamine in man, rat, and mouse. Cancer chemotherapy and pharmacology, 1982, Volume: 8, Issue:1 Topics: Altretamine; Animals; Antineoplastic Agents; Female; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Species Specificity; Triazines	1982
Specific determination of pentamethylmelamine and its demethylated metabolites in human plasma by high pressure liquid chromatography. Therapeutic drug monitoring, 1982, Volume: 4, Issue:2 Topics: Altretamine; Chromatography, High Pressure Liquid; Dealkylation; Humans; Kinetics; Triazines	1982
Routes of elimination of hexamethylmelamine and pentamethylmelamine in the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1982, Volume: 12, Issue:5 Topics: Altretamine; Animals; Bile; Feces; Male; Rats; Triazines	1982