Page last updated: 2024-08-25

penicillin n and cephalosporin c

penicillin n has been researched along with cephalosporin c in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19908 (33.33)18.7374
1990's3 (12.50)18.2507
2000's6 (25.00)29.6817
2010's6 (25.00)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Anderson, KC; Kellogg, GE; Sarkar, A1
Baker, BJ; Dotzlaf, JE; Yeh, WK1
Dotzlaf, JE; Yeh, WK1
Demain, AL; Jensen, SE; Shen, YQ; Westlake, DW; Wolfe, S1
Bowers, RJ; Jensen, SE; Lyubechansky, L; Westlake, DW; Wolfe, S1
Jensen, SE; Westlake, DW; Wolfe, S1
Martín, JF; Martin-Zanca, DM1
Baldwin, JE; Demain, AL; Sawada, Y; Singh, PD; Yoshida, M1
Baldwin, JE; Keeping, JW; Singh, PD; Vallejo, CA1
Faupel, M; Felix, HR; von Arx, E1
Barredo, JL; Díez, B; Fouces, R; Mellado, E; Rodríguez, M1
Adrio, JL; Cho, H; Demain, AL; Hintermann, G; Luengo, JM; Ocran, S; Piret, JM; Wolfe, S1
Hamilton-Miller, JM1
Baldwin, JE; Clifton, IJ; Harlos, K; Lee, HJ; Lloyd, MD; Schofield, CJ1
Adrio, JL; Barredo, JL; Moreno, MA; Rodriguez-Saiz, M; Soler, G; Velasco, J1
Baldwin, JE; Hensgens, CM; Hewitson, KS; Lipscomb, SJ; Lloyd, MD; Schofield, CJ1
Bunse, A; Friedlin, E; Hoff, B; Janus, D; Kück, U; Kürnsteiner, H; Schmitt, EK1
Casqueiro, J; Martín, JF; Naranjo, L; Ullán, RV; Vaca, I1
Guerra, SM; Martín, JF; Teijeira, F; Ullán, RV; Vaca, I1
Fernández-Aguado, M; Martín, JF; Teijeira, F; Ullán, RV1
An, Y; Dong, H; Liu, G1
García-Estrada, C; Martín, JF; Ullán, RV1
Cao, YX; Chen, Y; Lu, H; Qiao, B; Yuan, YJ1
Liu, Y; Shi, J1

Reviews

2 review(s) available for penicillin n and cephalosporin c

ArticleYear
Recombinant Acremonium chrysogenum strains for the industrial production of cephalosporin.
    Microbiologia (Madrid, Spain), 1996, Volume: 12, Issue:3

    Topics: Acetyltransferases; Acremonium; Bacterial Proteins; Cephalosporins; DNA, Fungal; DNA, Recombinant; Drug Industry; Fungal Proteins; Genes, Fungal; Hemoglobins; Industrial Microbiology; Intramolecular Transferases; Isomerases; Oxygenases; Penicillin G; Penicillin-Binding Proteins; Penicillins; Recombinant Fusion Proteins; Truncated Hemoglobins

1996
Role of peroxisomes in the biosynthesis and secretion of β-lactams and other secondary metabolites.
    Journal of industrial microbiology & biotechnology, 2012, Volume: 39, Issue:3

    Topics: Acyltransferases; Amino Acid Sequence; beta-Lactams; Biological Transport; Cephalosporins; Fungi; Hydrogen Peroxide; Molecular Sequence Data; Penicillin-Binding Proteins; Penicillins; Penicillium chrysogenum; Peroxisome-Targeting Signal 1 Receptor; Peroxisomes; Receptors, Cytoplasmic and Nuclear

2012

Other Studies

22 other study(ies) available for penicillin n and cephalosporin c

ArticleYear
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Anti-Bacterial Agents; beta-Lactams; Computational Biology; Drug Resistance, Bacterial; Hydrophobic and Hydrophilic Interactions; Ligands; Membrane Transport Proteins; Microbial Sensitivity Tests; Models, Molecular; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Regression Analysis; Thermodynamics

2012
Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication.
    The Journal of biological chemistry, 1991, Mar-15, Volume: 266, Issue:8

    Topics: Amino Acid Sequence; Biological Evolution; Cephalosporins; Cephamycins; Chromatography, Liquid; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Molecular Weight; Oxygenases; Penicillins; Sequence Homology, Nucleic Acid; Streptomyces

1991
Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium.
    Journal of bacteriology, 1987, Volume: 169, Issue:4

    Topics: Acremonium; Amino Acids; Cephalosporins; Chelating Agents; Hydrogen-Ion Concentration; Intramolecular Transferases; Isoelectric Point; Isomerases; Metals; Molecular Weight; Oxygenases; Penicillin-Binding Proteins; Penicillins; Substrate Specificity; Sulfhydryl Reagents; Temperature

1987
Further studies on the cyclization of the unnatural tripeptide delta-(D-alpha-aminoadipyl)-L-cysteinyl-D-valine to penicillin N.
    The Journal of antibiotics, 1986, Volume: 39, Issue:7

    Topics: Cephalosporins; Cyclization; Oligopeptides; Penicillins; Streptomyces

1986
Enzymatic synthesis of the penicillin and cephalosporin nuclei from an acyclic peptide containing carboxymethylcysteine.
    Biochemical and biophysical research communications, 1984, Apr-30, Volume: 120, Issue:2

    Topics: Amino Acid Isomerases; Bacterial Proteins; Biological Assay; Cephalosporins; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Enzymes; Oligopeptides; Oxidoreductases; Penicillins; Streptomyces

1984
Analysis of penicillin N ring expansion activity from Streptomyces clavuligerus by ion-pair high-pressure liquid chromatography.
    Antimicrobial agents and chemotherapy, 1983, Volume: 24, Issue:3

    Topics: Cephalosporins; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Culture Media; Penicillins; Spectrophotometry, Ultraviolet; Streptomyces

1983
Carbon catabolite regulation of the conversion of penicillin N into cephalosporin C.
    The Journal of antibiotics, 1983, Volume: 36, Issue:6

    Topics: Cephalosporins; Kinetics; Mitosporic Fungi; Multienzyme Complexes; Penicillins

1983
Incorporation of 3H and 14C from (6 alpha-3H)penicillin N and (10-14C,6 alpha-3H) penicillin N into deacetoxycephalosporin C.
    The Biochemical journal, 1980, Mar-15, Volume: 186, Issue:3

    Topics: Acremonium; Ascorbic Acid; Carbon Radioisotopes; Cephalosporins; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Ferrous Compounds; Penicillins; Tritium

1980
Cell-free conversion of isopenicillin N into deacetoxycephalosporin C by Cephalosporium acremonium mutant M-0198.
    The Biochemical journal, 1981, Feb-15, Volume: 194, Issue:2

    Topics: Acremonium; Cephalosporins; Chromatography, High Pressure Liquid; Penicillins

1981
Fast and simple method for the separation of intermediates and cofactors involved in the biosynthesis of cephalosporin C using chemically bonded C12 reversed-phase thin-layer chromatography.
    Journal of chromatography, 1980, May-30, Volume: 193, Issue:3

    Topics: Agar; Alcaligenes; Carbon; Cephalosporins; Chromatography, Thin Layer; Neisseria; Penicillins; Sarcina

1980
Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Sep-29, Volume: 95, Issue:20

    Topics: Adenosine Triphosphate; Ascorbic Acid; Cephalosporins; Colony Count, Microbial; Dithiothreitol; Ferrous Compounds; Interphase; Intramolecular Transferases; Ketoglutaric Acids; Kinetics; Magnesium Sulfate; Penicillin G; Penicillin-Binding Proteins; Penicillins; Potassium Chloride; Streptomyces

1998
Sir Edward Abraham's contribution to the development of the cephalosporins: a reassessment.
    International journal of antimicrobial agents, 2000, Volume: 15, Issue:3

    Topics: Cephalosporins; England; History, 20th Century; Penicillins

2000
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).
    Journal of molecular biology, 2001, May-18, Volume: 308, Issue:5

    Topics: Amino Acid Sequence; Carbon Dioxide; Cephalosporins; Crystallization; Crystallography, X-Ray; Intramolecular Transferases; Iron; Ketoglutaric Acids; Kinetics; Models, Molecular; Molecular Sequence Data; Penicillin-Binding Proteins; Penicillins; Protein Engineering; Protein Structure, Quaternary; Sequence Deletion; Streptomyces; Succinic Acid

2001
Extracellular production of biologically active deacetoxycephalosporin C synthase from Streptomyces clavuligerus in Pichia pastoris.
    Biotechnology and bioengineering, 2001, Nov-20, Volume: 75, Issue:4

    Topics: Cephalosporins; Clone Cells; Culture Media; Electroporation; Gene Expression; Gene Transfer Techniques; Hydrogen-Ion Concentration; Intramolecular Transferases; Methanol; Penicillin G; Penicillin-Binding Proteins; Penicillins; Periplasm; Pichia; Plasmids; Recombinant Proteins; Solvents; Streptomyces; Substrate Specificity; Time Factors

2001
Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.
    The Journal of biological chemistry, 2004, Apr-09, Volume: 279, Issue:15

    Topics: Acremonium; Amino Acid Sequence; Asparagine; Binding Sites; Cephalosporins; Cloning, Molecular; Intramolecular Transferases; Iron; Kinetics; Methionine; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxygen; Oxygenases; Penicillin-Binding Proteins; Penicillins; Point Mutation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Streptomyces; Substrate Specificity; Tryptophan

2004
Winged helix transcription factor CPCR1 is involved in regulation of beta-lactam biosynthesis in the fungus Acremonium chrysogenum.
    Eukaryotic cell, 2004, Volume: 3, Issue:1

    Topics: Acremonium; beta-Galactosidase; beta-Lactams; Binding Sites; Blotting, Southern; Blotting, Western; Cell Membrane; Cephalosporins; Chromatography, High Pressure Liquid; Escherichia coli; Fungal Proteins; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Lac Operon; Models, Genetic; Mutation; Nucleic Acid Hybridization; Penicillins; Peptides; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; RNA; RNA, Messenger; Time Factors; Transcription Factors; Transcriptional Activation

2004
Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis.
    Molecular genetics and genomics : MGG, 2004, Volume: 272, Issue:5

    Topics: Ascomycota; Blotting, Northern; Blotting, Southern; Cephalosporins; Genes, Fungal; Penicillins; Plasmids; Racemases and Epimerases; Time Factors; Transformation, Genetic

2004
Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C.
    The Biochemical journal, 2010, Dec-01, Volume: 432, Issue:2

    Topics: Acremonium; Base Sequence; Cell-Free System; Cephalosporins; DNA Primers; DNA, Fungal; Genes, Fungal; Genetic Complementation Test; Membrane Proteins; Molecular Sequence Data; Mutation; Penicillins; Penicillium chrysogenum; Peroxisomes; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction; RNA, Fungal

2010
CefR modulates transporters of beta-lactam intermediates preventing the loss of penicillins to the broth and increases cephalosporin production in Acremonium chrysogenum.
    Metabolic engineering, 2011, Volume: 13, Issue:5

    Topics: Acremonium; Carrier Proteins; Cephalosporins; Fungal Proteins; Gene Knockdown Techniques; Penicillins; Peroxisomes

2011
Expression of cefF significantly decreased deacetoxycephalosporin C formation during cephalosporin C production in Acremonium chrysogenum.
    Journal of industrial microbiology & biotechnology, 2012, Volume: 39, Issue:2

    Topics: Acremonium; Agrobacterium; Biotechnology; Cephalosporins; Fermentation; Genes, Fungal; Oxygenases; Penicillins; Streptomyces

2012
Comparison of the secondary metabolites in two scales of cephalosporin C (CPC) fermentation and two different post-treatment processes.
    Journal of industrial microbiology & biotechnology, 2013, Volume: 40, Issue:1

    Topics: 2-Aminoadipic Acid; Acremonium; Anti-Bacterial Agents; Cephalosporins; Fermentation; Oligopeptides; Penicillins

2013
Mechanistic Insights into the Oxidative Ring Expansion from Penicillin N to Deacetoxycephalosporin C Catalyzed by a Nonheme Iron(II) and α-KG-Dependent Oxygenase.
    Inorganic chemistry, 2020, Sep-08, Volume: 59, Issue:17

    Topics: Biocatalysis; Catalysis; Cephalosporins; Iron; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Oxygenases; Penicillins; Quantum Theory

2020