Page last updated: 2024-08-17

penicillin g and cefepime

penicillin g has been researched along with cefepime in 67 studies

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.49)18.7374
1990's0 (0.00)18.2507
2000's47 (70.15)29.6817
2010's18 (26.87)24.3611
2020's1 (1.49)2.80

Authors

AuthorsStudies
Carter, AL; Ganapathy, ME; Ganapathy, V; Huang, W; Iseki, K; Leibach, FH; Rajan, DP; Sugawara, M1
Brandsch, M; Luckner, P1
Biegel, A; Brandsch, M; Gebauer, S; Hartrodt, B; Neubert, K; Thondorf, I1
Cattoir, V; Nordmann, P; Poirel, L; Soares, A; Soussy, CJ1
Bonnet, R; Chanal, C; Delmas, J; Lesens, O; Robin, F; Schweitzer, C; Tournilhac, O1
Aubert, D; Naas, T; Nordmann, P; Ozcan, A1
Cattoir, V; Corvec, S; Drugeon, H; Faccone, D; Galas, M; Mugnier, P; Nordmann, P; Pasteran, F; Petroni, A; Poirel, L; Rapoport, M1
Ayala, JA; Casellas, JM; Di Conza, J; Ghiglione, B; Gutkind, G; Power, P; Radice, M; Rodríguez, MM1
Amicosante, G; Caporale, B; Celenza, G; Docquier, JD; Mezzatesta, M; Pellegrini, C; Perilli, M; Rossolini, GM; Stefani, S1
Bush, K; Kania, M; Page, MG; Queenan, AM; Shang, W1
Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS1
Bonnet, R; Brebion, A; Constantin, JM; Delmas, J; Dubois, D; Robin, F1
Girlich, D; Leclercq, R; Naas, T; Nordmann, P1
Courvalin, P; Decré, D; Høiby, EA; Meziane-Cherif, D; Périchon, B1
Amicosante, G; Celenza, G; De Santis, F; Forcella, C; Pellegrini, C; Perilli, M; Rossolini, GM; Stefani, S1
Fiett, J; Gniadkowski, M; Hakenbeck, R; Hryniewicz, W; Izdebski, R; Rutschmann, J; Sadowy, E1
Bouallegue, O; Mansour, W; Nordmann, P; Poirel, L1
Bonnet, R; Caniça, M; Ferreira, E; Manageiro, V; Mendonça, N; Robin, F; Salgado, MJ1
Bonnet, R; Caniça, M; Manageiro, V; Mendonça, N1
Limansky, AS; Marchiaro, P; Mussi, MA; Pasteran, F; Tomatis, PE; Viale, AM; Vila, AJ1
Doi, Y; Nordmann, P; Paterson, DL; Poirel, L1
Beckius, ML; Fraser, SL; Galloway, RL; Griffith, ME; Hospenthal, DR; Mende, K; Miller, RS; Murray, CK; Pimentel, G; Ressner, RA1
Chang, KY; Ho, YH; Hsieh, YC; Hsueh, PR; Huang, LM; Huang, YC; Lin, HC1
Lombardo, F; Obach, RS; Waters, NJ1
Docquier, JD; Frère, JM; Rossolini, GM; Stoczko, M1
Arakawa, Y; Kato, H; Kimura, K; Kurokawa, H; Nagano, N; Shibata, N; Shibayama, K; Suzuki, S; Wachino, J; Yamane, K1
Bauernfeind, A; Keuleyan, E; Markovska, R; Queenan, AM; Rasshofer, R; Schneider, I1
Castanheira, M; Samuelsen, Ø; Spencer, J; Walsh, TR1
Amsler, KM; Bush, K; Davies, TA; Jacobs, MR; Shang, W1
Biek, D; Ge, Y; Sahm, DF; Talbot, GH1
Albertí, S; Beceiro, A; Bou, G; Garau, M; Gutiérrez, O; Juan, C; Oliver, A; Pérez, JL1
Arpin, C; Bezian, MC; Coulange, L; Demarthe, F; Dubois, V; Minarini, LA; Nordmann, P; Poirel, L; Quentin, C1
Aguilar, L; Biek, D; Fenoll, A; Giménez, MJ; Granizo, JJ; Robledo, O; Tarragó, D1
Kanamori, M; Kirikae, T; Kitao, T; Miyoshi-Akiyama, T; Morita, K; Okazaki, M; Sekiguchi, J; Watanabe, N1
Arakawa, Y; Kimura, K; Nagano, N; Nagano, Y; Tamai, K; Yanagisawa, H1
Nordmann, P; Plésiat, P; Poirel, L; Rodriguez-Martinez, JM1
Kotsakis, SD; Miriagou, V; Tzelepi, E; Tzouvelekis, LS; Whichard, JM; Zioga, A1
Nordmann, P; Poirel, L; Rodríguez-Martínez, JM1
Bonnet, R; Brisabois, A; Cloeckaert, A; Doublet, B; Fabre, L; Granier, SA; Robin, F; Weill, FX1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Kotsakis, SD; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS1
Bauernfeind, A; Keuleyan, E; Markova, B; Markovska, R; Queenan, AM; Schneider, I1
De Luca, F; Delmarcelle, M; Docquier, JD; Dubus, A; Frère, JM; Nacoulma, OG; Rossolini, GM; Simporé, J; Zeba, B1
Cho, HS; Giske, CG; Lee, K; Sundman, K; Toleman, MA; Walsh, TR; Yong, D1
Higgins, PG; Lehmann, M; Nordmann, P; Poirel, L; Seifert, H1
Bonnet, R; Casin, I; Doublet, B; Fabre, L; Le Fleche, A; Robin, F; Weill, FX1
De Luca, F; Docquier, JD; Ide, L; Nordmann, P; Poirel, L; Rossolini, GM; Verlinde, A1
Girlich, D; Nordmann, P; Poirel, L2
Aggoune-Khinache, N; Bonnet, R; Delmas, J; Naim, M; Robin, F1
Amoroso, A; Coyette, J; Henry, X; Joris, B1
Fortineau, N; Nordmann, P; Poirel, L; Rodriguez-Martinez, JM1
Kotsakis, SD; Legakis, NJ; Miriagou, V; Papagiannitsis, CC; Tzelepi, E; Tzouvelekis, LS1
De Luca, F; Docquier, JD; Fosse, T; Giraud-Morin, C; Rossolini, GM1
Al Naiemi, N; Debets-Ossenkopp, YJ; Nordmann, P; Poirel, L; Rodríguez-Martínez, JM1
Nordmann, P; Poirel, L; Rodríguez-Martínez, JM; Ronco, E1
Borgianni, L; Docquier, JD; Hanson, ND; Prandi, S; Rossolini, GM; Salden, L; Santella, G1
Aldini, G; De Luca, L; Marconi, C; Pedretti, A; Regazzoni, L; Vistoli, G1
Anderson, KC; Kellogg, GE; Sarkar, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bayer, A; Christopeit, T; Guttormsen, Y; Leiros, HK; Lund, BA1
Barbosa, G; Barreiro, EJ; Lima, LM; Silva, BNMD1
Bayer, AS; Kim, KS1
Karasawa, T; Kuriyama, T; Nakagawa, K; Nakamura, S; Yamamoto, E1
Cheng, CJ; Chou, CH; Lin, CS; Lin, SH1
Chumjan, W; Hajjar, E; Mahendran, KR; Schulte, A; Suginta, W; Weingart, H; Winterhalter, M1
Almuzara, M; Chiem, K; Collins, C; Iriarte, A; Montaña, S; Mussi, MA; Ramirez, MS; Saigo, M; Tolmasky, M; Traglia, G; Vay, C1

Reviews

2 review(s) available for penicillin g and cefepime

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
β-lactam antibiotics: An overview from a medicinal chemistry perspective.
    European journal of medicinal chemistry, 2020, Dec-15, Volume: 208

    Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Chemistry, Pharmaceutical; Humans; Hydrolysis; Models, Chemical; Molecular Structure

2020

Trials

1 trial(s) available for penicillin g and cefepime

ArticleYear
In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Anti-Bacterial Agents; Cephalosporins; Enterobacteriaceae; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Skin Diseases, Bacterial; Staphylococcus

2008

Other Studies

64 other study(ies) available for penicillin g and cefepime

ArticleYear
beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.
    The Journal of biological chemistry, 2000, Jan-21, Volume: 275, Issue:3

    Topics: Acetylcarnitine; Animals; Anti-Bacterial Agents; Carnitine; Carrier Proteins; Cefadroxil; Cefepime; Cephaloridine; Cephalosporins; Dose-Response Relationship, Drug; HeLa Cells; Humans; Kinetics; Membrane Proteins; Nitrogen; Organic Cation Transport Proteins; Rats; Sodium; Solute Carrier Family 22 Member 5; Tumor Cells, Cultured

2000
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2005, Volume: 59, Issue:1

    Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Binding Sites; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Peptide Transporter 1; Protein Binding; Rats; Symporters

2005
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.
    Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

    Topics: Animals; beta-Lactams; Cell Line, Tumor; Dipeptides; Drug Design; Humans; Mammals; Models, Molecular; Oligopeptides; Peptide Transporter 1; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters

2005
Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2

    Topics: Amino Acid Sequence; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Cloning, Molecular; Enterobacter cloacae; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Plasmids; Quinolones; Sequence Alignment

2007
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: beta-Lactamases; Drug Resistance, Bacterial; Escherichia coli; Evolution, Molecular; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation

2007
Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: beta-Lactamases; Chromosomes; Chromosomes, Bacterial; Citrobacter; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genes, Bacterial; Molecular Sequence Data

2007
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6

    Topics: Acinetobacter; Acinetobacter Infections; Amino Acid Sequence; Anti-Bacterial Agents; Argentina; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Clavulanic Acid; Cloning, Molecular; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA

2007
Biochemical characterization of PER-2 and genetic environment of blaPER-2.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Amino Acid Sequence; Base Sequence; beta-Lactam Resistance; beta-Lactamases; Catalysis; Citrobacter freundii; Conjugation, Genetic; DNA, Bacterial; DNA, Recombinant; Enterobacteriaceae; Genes, Bacterial; Humans; Hydrolysis; Isoelectric Focusing; Kinetics; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Weight; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Conformation; Protein Sorting Signals; Sequence Analysis, DNA

2007
Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cephalosporins; Chryseobacterium; Flavobacteriaceae Infections; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillins; Sequence Analysis, DNA

2007
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9

    Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamases; Cefepime; Ceftazidime; Cephalosporins; Hydrolysis; Kinetics; Microbial Sensitivity Tests; Spectrophotometry, Ultraviolet

2007
Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10

    Topics: Anti-Bacterial Agents; Cephalosporinase; Culture Media; DNA Primers; Drug Resistance, Bacterial; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Spectrophotometry, Ultraviolet

2007
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Catalysis; Ceftazidime; Clavulanic Acid; Escherichia coli; Escherichia coli Proteins; Isoenzymes; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA

2007
Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: Amino Acid Sequence; Bacillus; Bacterial Proteins; beta-Lactamases; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Weight; Sequence Homology, Amino Acid; Substrate Specificity

2007
Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2

    Topics: Amino Acid Sequence; beta-Lactams; Chromosomes, Bacterial; Cloning, Molecular; Electrophoresis, Gel, Pulsed-Field; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant, Newborn; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillin Resistance; Penicillinase; Sequence Alignment; Sequence Analysis, DNA; Substrate Specificity

2008
E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3

    Topics: Amino Acid Substitution; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Catalysis; Ceftazidime; Enterobacter aerogenes; Humans; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Sequence Analysis, DNA; Serratia marcescens; Structure-Activity Relationship; Substrate Specificity

2008
Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3

    Topics: Amino Acid Sequence; Aminoacyltransferases; Anti-Bacterial Agents; Antigenic Variation; Bacterial Proteins; Boron Compounds; Clone Cells; Genetic Variation; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillin Resistance; Penicillin-Binding Proteins; Penicillins; Peptidyl Transferases; Poland; Sequence Analysis, DNA; Streptococcus pneumoniae

2008
Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Acinetobacter baumannii; Africa; Bacterial Proteins; beta-Lactamases; Blotting, Southern; Carbapenems; Cross Infection; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Models, Genetic; Molecular Sequence Data; Polymerase Chain Reaction; Tunisia

2008
The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Amino Acid Substitution; Amoxicillin; Anti-Bacterial Agents; Arginine; Aztreonam; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporins; Clavulanic Acid; Computer Simulation; Imipenem; Isoelectric Focusing; Kinetics; Klebsiella pneumoniae; Lysine; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Penicillins; Protein Conformation; Protein Structure, Tertiary

2008
Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Anti-Bacterial Agents; beta-Lactamases; Kinetics; Klebsiella pneumoniae

2008
Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Binding Sites; Escherichia coli; Humans; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Plasmids; Pseudomonas aeruginosa; Pseudomonas Infections

2008
Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Achromobacter denitrificans; Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cloning, Molecular; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA

2008
Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Ampicillin; Anti-Bacterial Agents; Azithromycin; Cefepime; Cefotaxime; Ceftriaxone; Cephalosporins; Ciprofloxacin; Egypt; Hawaii; Humans; Leptospira; Leptospirosis; Levofloxacin; Microbial Sensitivity Tests; Nicaragua; Ofloxacin; Tetracycline; Thailand

2008
Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactams; Genotype; Humans; Microbial Sensitivity Tests; Pneumococcal Infections; Serotyping; Streptococcus pneumoniae; Taiwan

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; beta-Lactamases; Cloning, Molecular; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Genes, Bacterial; Molecular Sequence Data; Open Reading Frames; Pectobacterium carotovorum; Phenotype; Phylogeny; Recombinant Proteins; Sequence Homology, Amino Acid

2008
First molecular characterization of group B streptococci with reduced penicillin susceptibility.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Amino Acid Sequence; Amino Acid Substitution; Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; Blotting, Western; Cefepime; Cefotaxime; Ceftizoxime; Cephalosporins; Electrophoresis, Gel, Pulsed-Field; Humans; Japan; Microbial Sensitivity Tests; Molecular Sequence Data; Oxacillin; Penicillin Resistance; Penicillin-Binding Proteins; Penicillins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Streptococcal Infections; Streptococcus agalactiae

2008
VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Amino Acid Substitution; Bacterial Proteins; beta-Lactamases; Bulgaria; Catalysis; Germany; Hydrolysis; Isoenzymes; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Pseudomonas aeruginosa; Sequence Analysis, DNA

2008
Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Acremonium; Bacterial Proteins; beta-Lactamases; Catalysis; Catalytic Domain; Cefepime; Ceftazidime; Cephalosporins; Kinetics; Models, Molecular; Mutation; Penicillinase; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity

2008
In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; United States

2008
Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; beta-Lactam Resistance; beta-Lactamases; Cloning, Molecular; DNA Primers; DNA, Bacterial; Genes, Bacterial; Genetic Variation; Humans; Imipenem; Integrons; Kinetics; Meropenem; Molecular Sequence Data; Phylogeny; Pseudomonas aeruginosa; Pseudomonas Infections; Recombinant Proteins; Sequence Homology, Amino Acid; Spain; Thienamycins

2008
Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10

    Topics: Aged; Amino Acid Substitution; Base Sequence; beta-Lactam Resistance; beta-Lactamases; DNA Primers; DNA, Bacterial; Female; Genes, Bacterial; Humans; Isoelectric Point; Kinetics; Klebsiella Infections; Klebsiella pneumoniae; Molecular Sequence Data; Mutagenesis, Insertional; Recombinant Proteins

2008
In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11

    Topics: Amoxicillin; Anti-Bacterial Agents; Cefotaxime; Ceftaroline; Cephalosporin Resistance; Cephalosporins; Drug Resistance, Multiple, Bacterial; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Penicillin Resistance; Penicillins; Pneumococcal Infections; Streptococcus pneumoniae

2008
KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11

    Topics: Amino Acid Sequence; Base Sequence; beta-Lactam Resistance; beta-Lactamases; Citrobacter freundii; Conjugation, Genetic; DNA Primers; DNA, Bacterial; Enterobacteriaceae Infections; Escherichia coli K12; Genes, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Plasmids; Recombinant Proteins; Sequence Homology, Amino Acid

2008
Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:12

    Topics: Aminoacyltransferases; Anti-Bacterial Agents; Bacterial Proteins; Female; Genetic Heterogeneity; Humans; Infant, Newborn; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillin Resistance; Penicillin-Binding Proteins; Penicillins; Phylogeny; Sequence Analysis, DNA; Streptococcus agalactiae

2008
Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Alleles; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; beta-Lactamases; Burkholderia cepacia complex; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Hydrolysis; Isoelectric Point; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Plasmids; Sequence Analysis, DNA; Sequence Homology, Amino Acid

2009
CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Alleles; Amino Acid Sequence; Amino Acid Substitution; Arginine; Base Sequence; beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporinase; Citrobacter freundii; Cysteine; DNA Transposable Elements; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Glutamine; Humans; Hydrolysis; Inhibitory Concentration 50; Isoelectric Point; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Models, Genetic; Models, Molecular; Molecular Sequence Data; Plasmids; Salmonella enterica; Sequence Analysis, DNA; Species Specificity; Substrate Specificity; Transformation, Genetic

2009
Extended-spectrum cephalosporinases in Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Ceftazidime; Cephalosporinase; Humans; Imipenem; Microbial Sensitivity Tests; Molecular Sequence Data; Pseudomonas aeruginosa; Sequence Analysis, DNA

2009
Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cardiidae; Ceftazidime; Ceftriaxone; Cephalosporin Resistance; Electrophoresis, Gel, Pulsed-Field; France; Microbial Sensitivity Tests; Plasmids; Polymerase Chain Reaction; Salmonella enterica; Serotyping

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Aztreonam; beta-Lactamases; beta-Lactams; Ceftazidime; Cephalosporins; Escherichia coli Proteins; Protein Binding; Protein Structure, Secondary

2009
New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Anti-Bacterial Agents; beta-Lactamases; Bulgaria; Cefepime; Cefotaxime; Ceftazidime; Cephalosporins; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Sequence Data

2009
IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Adult; Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Cefepime; Ceftazidime; Cephalexin; Cephalosporins; Cephalothin; Chryseobacterium; Female; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Protein Structure, Secondary; Sequence Homology, Amino Acid

2009
Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Carboxylic Ester Hydrolases; Cefotaxime; Cefuroxime; Cephalosporins; Cephalothin; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Humans; India; Kinetics; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillins; Sequence Analysis, DNA; Sequence Homology, Amino Acid

2009
OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12

    Topics: Acinetobacter baumannii; Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Drug Resistance, Multiple, Bacterial; Escherichia coli; Imipenem; Meropenem; Molecular Sequence Data; Oxacillin; Penicillins; Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thienamycins

2009
Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactamases; Catheters, Indwelling; Chromosomes, Bacterial; Cloning, Molecular; Electrophoresis, Gel, Pulsed-Field; Genes, Bacterial; Genetic Variation; Isoelectric Focusing; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Plasmids; Pseudomonas; Pseudomonas Infections; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity

2010
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Belgium; beta-Lactamases; Cephalosporinase; Cephalosporins; Cross Infection; Escherichia coli; Genes, Bacterial; Humans; Kinetics; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections

2010
Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Blotting, Southern; Cloning, Molecular; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; France; Fresh Water; Gram-Negative Bacteria; Health Surveys; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Pseudomonas fluorescens; Water Microbiology

2010
Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Algeria; Anti-Bacterial Agents; Base Sequence; beta-Lactamases; beta-Lactams; Carbapenems; DNA, Bacterial; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Genome, Bacterial; Hospitals, Military; Imipenem; Isoelectric Focusing; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillins; Phenotype

2010
Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Cephalosporins; Enterococcus faecium; Microbial Sensitivity Tests; Penicillin G; Protein Binding

2010
VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Isoelectric Focusing; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Protein Conformation; Reverse Transcriptase Polymerase Chain Reaction

2010
GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactamases; beta-Lactams; Cephalosporins; Genetic Variation; Humans; Integrons; Microbial Sensitivity Tests; Molecular Sequence Data; Pseudomonas aeruginosa; Pseudomonas Infections; Sequence Analysis, DNA

2010
Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:4

    Topics: Aeromonas; Amino Acid Sequence; Base Sequence; beta-Lactamases; Cloning, Molecular; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Genes, Bacterial; Humans; Kinetics; Molecular Sequence Data; Phylogeny; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Transformation, Genetic

2010
PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:4

    Topics: Aeromonas; Animals; Base Sequence; beta-Lactamases; DNA Primers; DNA, Bacterial; Genes, Bacterial; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Paris; Water Microbiology

2010
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; beta-Lactamases; Cloning, Molecular; DNA, Bacterial; Drug Resistance, Bacterial; Genes, Bacterial; Humans; Integrons; Middle Aged; Molecular Sequence Data; Netherlands; Pseudomonas Infections; Pseudomonas stutzeri; Sequence Homology, Amino Acid; Substrate Specificity

2010
Extended-spectrum cephalosporinase in Acinetobacter baumannii.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8

    Topics: Acinetobacter baumannii; Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Aztreonam; Bacterial Proteins; beta-Lactamases; Cefepime; Ceftazidime; Cephalosporin Resistance; Cephalosporinase; Cephalosporins; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Monobactams; Mutagenesis, Site-Directed

2010
Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1

    Topics: Amino Acid Sequence; Bacterial Proteins; beta-Lactamases; beta-Lactams; Ertapenem; Meropenem; Microbial Sensitivity Tests; Models, Genetic; Molecular Sequence Data; Open Reading Frames; Pseudomonas aeruginosa; Sequence Homology, Amino Acid; Thienamycins; United States

2011
Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.
    Bioorganic & medicinal chemistry, 2011, Aug-01, Volume: 19, Issue:15

    Topics: Binding Sites; Computer Simulation; Drug Design; Humans; Ligands; Models, Molecular; Peptides; Protein Binding; Structural Homology, Protein; Symporters

2011
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Anti-Bacterial Agents; beta-Lactams; Computational Biology; Drug Resistance, Bacterial; Hydrophobic and Hydrophilic Interactions; Ligands; Membrane Transport Proteins; Microbial Sensitivity Tests; Models, Molecular; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Regression Analysis; Thermodynamics

2012
Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening.
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: beta-Lactamase Inhibitors; beta-Lactamases; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Surface Plasmon Resonance

2016
Efficacy of BMY-28142 in experimental bacteremia and meningitis caused by Escherichia coli and group B streptococci.
    Antimicrobial agents and chemotherapy, 1985, Volume: 28, Issue:1

    Topics: Animals; Cefepime; Cefotaxime; Cephalosporins; Escherichia coli; Female; Meningitis; Microbial Sensitivity Tests; Penicillin G; Pregnancy; Rats; Rats, Inbred Strains; Sepsis; Streptococcal Infections; Streptococcus agalactiae

1985
Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics.
    Oral microbiology and immunology, 2002, Volume: 17, Issue:5

    Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bacteroidaceae Infections; beta-Lactams; Cefepime; Cefmetazole; Cefoperazone; Cefpirome; Ceftazidime; Ceftizoxime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Fusobacterium; Fusobacterium Infections; Gram-Positive Bacterial Infections; Humans; Imipenem; Lactams; Microbial Sensitivity Tests; Mouth Diseases; Penicillin G; Penicillins; Peptostreptococcus; Porphyromonas gingivalis; Prevotella; Streptococcal Infections; Streptococcus; Sulbactam

2002
Piperacillin/tazobactam-induced seizure rapidly reversed by high flux hemodialysis in a patient on peritoneal dialysis.
    The American journal of the medical sciences, 2007, Volume: 333, Issue:3

    Topics: Anti-Bacterial Agents; Brain; Bronchiectasis; Cefazolin; Cefepime; Cephalosporins; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Molecular Structure; Penicillanic Acid; Penicillin G; Peritoneal Dialysis, Continuous Ambulatory; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Dialysis; Tomography, X-Ray Computed

2007
Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain.
    Biochimica et biophysica acta, 2011, Volume: 1808, Issue:6

    Topics: Amino Acid Sequence; Anti-Infective Agents; Bacterial Outer Membrane Proteins; beta-Lactams; Biological Transport; Burkholderia pseudomallei; Cefepime; Ceftazidime; Cephalosporins; Ertapenem; Humans; Imipenem; Kinetics; Lipid Bilayers; Melioidosis; Meropenem; Models, Molecular; Molecular Sequence Data; Norfloxacin; Penicillin G; Phospholipids; Porins; Protein Conformation; Sequence Homology, Amino Acid; Thienamycins

2011
Whole-Genome Analysis of an Extensively Drug-Resistance Empedobacter falsenii Strain Reveals Distinct Features and the Presence of a Novel Metallo-ß-Lactamase (EBR-2).
    Current microbiology, 2018, Volume: 75, Issue:8

    Topics: Amino Acid Sequence; Ampicillin; Anti-Bacterial Agents; beta-Lactamases; Cefepime; Cephalosporins; Cross Infection; Drug Resistance, Multiple, Bacterial; Flavobacteriaceae; Genome, Bacterial; Humans; Meropenem; Microbial Sensitivity Tests; Penicillin G; Thienamycins

2018