penciclovir and 2--3--dideoxyguanosine

penciclovir has been researched along with 2--3--dideoxyguanosine* in 1 studies

Other Studies

1 other study(ies) available for penciclovir and 2--3--dideoxyguanosine

Article	Year
Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:5 Penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yI)guanine], an effective antiherpesvirus agent, was found to be a potent and selective antiviral agent against intracellular hepatitis B virus (HBV) replication (drug concentration at which a 10-fold decrease in HBV DNA from the average level in an untreated culture was observed [EC90], 1.6 microM) and extracellular virion release (EC90, 0.7 microM) by cultured human hepatoblastoma (2.2.15) cells. Acyclovir and three other related 9-alkoxypurines with activity against either herpesviruses or human immunodeficiency virus were uniformly inactive against HBV. The activity of penciclovir is discussed in relation to recent findings related to its mode of action against HBV. Topics: Acyclovir; Antiviral Agents; Cell Line; Dideoxynucleosides; DNA-Directed DNA Polymerase; Guanine; Hepatitis B virus; Hepatoblastoma; Humans; Lamivudine; Microbial Sensitivity Tests; Virus Replication	1996

Article

Year

Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells.

Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:5

Penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yI)guanine], an effective antiherpesvirus agent, was found to be a potent and selective antiviral agent against intracellular hepatitis B virus (HBV) replication (drug concentration at which a 10-fold decrease in HBV DNA from the average level in an untreated culture was observed [EC90], 1.6 microM) and extracellular virion release (EC90, 0.7 microM) by cultured human hepatoblastoma (2.2.15) cells. Acyclovir and three other related 9-alkoxypurines with activity against either herpesviruses or human immunodeficiency virus were uniformly inactive against HBV. The activity of penciclovir is discussed in relation to recent findings related to its mode of action against HBV.

Topics: Acyclovir; Antiviral Agents; Cell Line; Dideoxynucleosides; DNA-Directed DNA Polymerase; Guanine; Hepatitis B virus; Hepatoblastoma; Humans; Lamivudine; Microbial Sensitivity Tests; Virus Replication

1996