peloruside-a has been researched along with 3-hydroxybutanal* in 2 studies
2 other study(ies) available for peloruside-a and 3-hydroxybutanal
Article | Year |
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Dinuclear zinc-ProPhenol-catalyzed enantioselective α-hydroxyacetate aldol reaction with activated ester equivalents.
An enantioselective α-hydroxyacetate aldol reaction that employs N-acetyl pyrroles as activated ester equivalents and generates syn 1,2-diols in good yield and diastereoselectivity is reported. This dinuclear zinc-ProPhenol-catalyzed transformation proceeds with high enantioselectivity with a wide variety of substrates including aryl, alyl, and alkenyl aldehydes. The resulting α,β-dihydroxy activated esters are versatile intermediates for the synthesis of a variety of carboxylic acid derivatives including amides, esters, and unsymmetrical ketones. Topics: Alcohols; Aldehydes; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Combinatorial Chemistry Techniques; Esters; Ketones; Lactones; Molecular Structure; Pyrroles; Stereoisomerism; Zinc | 2013 |
Toward the synthesis of (+)-peloruside A via an intramolecular vinylogous aldol reaction.
The use of the intramolecular vinylogous aldol reaction for the preparation of an advanced intermediate for the synthesis of peloruside A is described. The reaction was applied to compound 19 and proceeds in high yield and good levels of diastereoselectivity. Application of the Achmatowicz reaction to this intermediate provided the corresponding pyranone, a late stage intermediate well positioned for conversion to the natural product. Topics: Aldehydes; Bridged Bicyclo Compounds, Heterocyclic; Cyclization; Lactones; Molecular Structure; Stereoisomerism; Vinyl Compounds | 2012 |