pd 98059 has been researched along with y 27632 in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (77.78) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Gonias, SL; Jo, M; Somlyo, AP; Somlyo, AV; Thomas, KS | 1 |
| Helfman, DM; Pawlak, G | 1 |
| Basdra, EK; Kletsas, D; Papavassiliou, AG | 1 |
| Fujii, K; Fukuhara, M; Iida, M; Lin, Y; Matsumura, K; Tsuchihashi, T | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Roberts, RE | 1 |
| Funfar, MR; Korpi, NL; McCoy, AC; Olmschenk, SM; Provost, JJ; Thronson, HL; Wallert, MA | 1 |
| Goez, P; Hagelgans, A; Hempel, U; Heyne, B; Jaross, W; Menschikowski, M; Neumeister, V; Siegert, G | 1 |
| Bae, YM; Cho, S; Choi, WH; Kim, B; Kim, J; Lee, CH; Lee, CK; Lee, YR | 1 |
| Chen, CP; Chen, JC; Ho, FM; Hsu, HB; Jeng, KC; Lee, ST; Lin, WW | 1 |
| Matsusaka, S; Wakabayashi, I | 1 |
| Ahn, DS; Cho, YE; Choi, SK; Kim, YH; Lee, YH; Morgan, KG; Ryu, SK | 1 |
| Annabi, B; Duhamel, S; Galipeau, J; Lejeune, L; Meriane, M | 1 |
| Chen, JW; Chen, YH; Chen, YL; Hsieh, LY; Ku, HH; Lin, CY; Lin, FY; Lin, SJ; Wang, SH; Wang, YC | 1 |
| Gambaryan, S; Roewer, N; Tas, PW | 1 |
| Kanda, S; Kanetake, H; Miyata, Y | 1 |
| Giehl, K; Goppelt-Struebe, M; Graness, A | 1 |
| Gahtan, V; Lawler, J; Maier, KG; Sadowitz, B; Seymour, KA; Stein, JJ | 1 |
| Bao, SL; Kuang, ZJ; Li, YG; Mao, YY; Tang, CS; Wei, RH; Wu, LB; Zhang, YG | 1 |
| Andrews, MA; Austin, M; Ibe, BO; Lazaro, M; Lustina, J; Raj, JU; Renteria, LS | 1 |
| Kaidoh, M; Kawai, Y; Ohhashi, T; Yokoyama, Y | 1 |
| Choi, SY; Hahn, S; Jee, J; Jeong, S; Jeong, SY; Kim, HK; Kim, HS; Kim, MS; Park, JS; Shin, H; Yoo, J | 1 |
27 other study(ies) available for pd 98059 and y 27632
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.
Topics: Amides; Cell Line; Cell Movement; Collagen; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Guanosine Triphosphate; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; ras Proteins; rho GTP-Binding Proteins; Time Factors; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2002 |
Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts.
Topics: Actin Cytoskeleton; Amides; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Chromones; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Oncogene Protein p21(ras); Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Transcription, Genetic; Transfection | 2002 |
Effect of protein kinase inhibitors on the stretch-elicited c-Fos and c-Jun up-regulation in human PDL osteoblast-like cells.
Topics: Amides; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; rho-Associated Kinases; Stress, Mechanical; Up-Regulation | 2002 |
Role of ERK and Rho kinase pathways in central pressor action of urotensin II.
Topics: Amides; Androstadienes; Animals; Blood Pressure; Consciousness; Drug Synergism; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Urotensins; Wortmannin | 2004 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
The role of Rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein.
Topics: Amides; Animals; Brimonidine Tartrate; Drug Interactions; Flavonoids; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Myosin Light Chains; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Receptors, Adrenergic, alpha-2; rho-Associated Kinases; Swine; Vasoconstriction; Veins | 2004 |
Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway.
Topics: Amides; Animals; Butadienes; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Hydrogen-Ion Concentration; Intracellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Kinase 1; Nitriles; Phenylephrine; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Pyridines; Receptors, Adrenergic, alpha; Receptors, G-Protein-Coupled; rho-Associated Kinases; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection | 2005 |
Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells.
Topics: Amides; Aorta; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Butadienes; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Drug Synergism; Flavonoids; Group II Phospholipases A2; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Janus Kinase 2; Lovastatin; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrroles; RNA Stability; Up-Regulation | 2005 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hypertension; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasodilator Agents; Verapamil | 2005 |
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.
Topics: Amides; Animals; Antioxidants; Ascorbic Acid; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hemin; I-kappa B Kinase; Immunoblotting; Interferon Regulatory Factor-1; Interferon-gamma; Lipopolysaccharides; Luciferases; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Phosphorylation; Pyridines; Quercetin; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Transcription Factor AP-1; Transfection | 2005 |
5-Hydroxytryptamine as a potent migration enhancer of human aortic endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aorta; Benzamides; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluoxetine; Humans; Microscopy, Video; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Pyridines; rhoA GTP-Binding Protein; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Antagonists; Stress Fibers; Time Factors | 2005 |
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
Topics: Amides; Animals; Calcium; Flavonoids; Hypertension; Mesenteric Arteries; Mitogen-Activated Protein Kinases; Myosin Light Chains; Naphthalenes; Phosphorylation; Phosphorylcholine; Protein Kinase C; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Sphingosine; Vasoconstriction | 2006 |
Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived str
Topics: Actin Cytoskeleton; Amides; Animals; Bone Marrow Cells; Cell Shape; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Hydroxamic Acids; Indoles; Intracellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Paxillin; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Sphingosine; Stromal Cells | 2006 |
Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.
Topics: Amides; Anthracenes; Aorta; Blotting, Western; Boron Compounds; cdc42 GTP-Binding Protein; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Endothelial Cells; Enzyme Activation; Flavonoids; Humans; Imidazoles; Leucine; Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Protein Transport; Pyridines; rac1 GTP-Binding Protein; Thrombomodulin; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.
Topics: Adrenergic beta-Agonists; Amides; Anesthetics, Inhalation; Animals; Cell Line, Tumor; Cell Shape; Culture Media, Serum-Free; Enzyme Activation; Flavonoids; Glioma; Halothane; Isoflurane; Isoproterenol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oncogene Protein v-akt; Pyridines; Rats; rhoA GTP-Binding Protein; Signal Transduction | 2007 |
Long-term exposure of human renal carcinoma cells to PD98059 induces epithelial-mesenchymal transition-like phenotype and enhanced motility.
Topics: Amides; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Enzyme Activation; Epithelium; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Mesoderm; Phenotype; Pyridines; rhoA GTP-Binding Protein; Stress Fibers; Time Factors | 2008 |
The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression.
Topics: Actins; Amides; Aminoquinolines; Animals; Cell Adhesion; Cell Shape; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesions; Gene Expression; Mesangial Cells; Microtubules; Nocodazole; Paxillin; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Thrombospondin 1 | 2008 |
Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated.
Topics: Amides; Cell Movement; Cells, Cultured; Chemotaxis; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organophosphonates; Protein Folding; Pyridines; Pyrimidines; Signal Transduction; Thrombospondin 1 | 2011 |
Osteopontin is involved in urotensin II-induced migration of rat aortic adventitial fibroblasts.
Topics: Amides; Animals; Calcium Channels; Cell Movement; Culture Media; Cyclosporine; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Gene Expression Regulation; Male; Nicardipine; Oligonucleotides; Oligonucleotides, Antisense; Osteopontin; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Time Factors; Urotensins | 2011 |
RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Imidazoles; Lung; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Mutation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Sheep | 2013 |
Pivotal roles of lymphatic endothelial cell layers in the permeability to hydrophilic substances through collecting lymph vessel walls: effects of inflammatory cytokines.
Topics: Amides; Cell Membrane Permeability; Cells, Cultured; Cytokines; Endothelial Cells; Flavonoids; Humans; Inflammation Mediators; Lymphatic Vessels; Phosphorylation; Pyridines | 2014 |
Leucine-rich repeat-containing G-protein coupled receptor 5 enriched organoids under chemically-defined growth conditions.
Topics: Adult Stem Cells; Amides; Animals; Cell Self Renewal; Culture Media, Serum-Free; Flavonoids; Gene Expression; Humans; Intestinal Mucosa; Mice; Mice, Transgenic; Organoids; Pyrazoles; Pyridines; Pyrimidines; Receptors, G-Protein-Coupled; RNA, Messenger; Thiosemicarbazones; Valproic Acid | 2019 |