pd 98059 has been researched along with wortmannin in 380 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 95 (25.00) | 18.2507 |
| 2000's | 247 (65.00) | 29.6817 |
| 2010's | 38 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Granner, DK; Osawa, H; Printz, RL; Robey, RB; Sutherland, C | 1 |
| Hue, L; Lefebvre, V; Louckx, MP; Méchin, MC; Rider, MH | 1 |
| Calera, MR; Farmer, SR; Milasincic, DJ; Pilch, PF | 1 |
| Avdi, NJ; Johnson, GL; Russel, M; Winston, BW; Worthen, GS; Young, SK | 1 |
| LeRoith, D; Párrizas, M; Saltiel, AR | 1 |
| Borthwick, AC; Hurel, SJ; Rochford, JJ; Turnbull, DM; Vandenheede, JR; Wells, AM; Yeaman, SJ | 1 |
| Klippel, A; Kulik, G; Weber, MJ | 1 |
| Johnson, GL; Knall, C; Worthen, GS | 1 |
| Blenis, J; Grammer, TC | 1 |
| DaSilva, L; Erwin, RA; Farrar, WL; Hennighausen, L; Kirken, RA; Liu, X; Malabarba, MG; Rui, H; Xu, J | 1 |
| Dubois, C; Garcia, A; Montarras, D; Pinset, C; Rousse, S | 1 |
| Baumbach, WR; Ho, KK; Leung, KC; Markus, I; Waters, MJ | 1 |
| Kaziro, Y; Koide, H; Suzuki, J | 1 |
| Foulstone, E; Haigh, RJ; Nave, BT; Proud, C; Rincon, J; Shepherd, PR; Siddle, K; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Dong, LQ; Du, H; Fan, J; Kolakowski, LF; Lee, AV; Liu, F; Mandarino, J; Mandarino, LJ; Porter, SG; Yee, D | 1 |
| Bono, F; Herbert, JM; Lamarche, I | 1 |
| Carlsen, J; Christiansen, K; Vinten, J | 1 |
| Fryer, LG; Holness, MJ; Sugden, MC | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Coffer, PJ; Geijsen, N; Koenderman, L; Lammers, JW; M'rabet, L; Maikoe, T; Raaijmakers, JA; Schweizer, RC | 1 |
| Abboud, HE; Bardgette, J; Choudhury, GG; Gentilini, A; Hernandez, J; Karamitsos, C | 1 |
| Horetsky, RL; Jefferson, LS; Kimball, SR | 1 |
| Finlay, BB; Gold, MR; Sutherland, CL; Tang, P | 1 |
| Foncea, R; Lavandero, S; Pérez, V; Sapag-Hagar, M | 1 |
| Cheresh, DA; Klemke, R; Li, E; Nemerow, GR; Stupack, D | 1 |
| Brambilla, E; Kahn, CR; Landaker, EJ; Luzi, L; Patti, ME | 1 |
| Car, BD; Meunier, PC; Schnyder, B | 1 |
| Bernier, M; Lee-Kwon, W; Park, D | 1 |
| Jackson, JG; White, MF; Yee, D | 1 |
| de Jonge, HR; Dorrestijn, J; Maassen, JA; Narumiya, S; Tilly, BC; van der Wijk, T | 1 |
| Kanatsuka, A; Makino, H; Onuma, H; Osawa, H; Saito, Y; Suzuki, Y; Taira, M | 1 |
| Anand-Srivastava, MB; Pandey, SK; Srivastava, AK | 1 |
| Greene, LA; Yan, CY | 1 |
| Cheng, HL; Feldman, EL | 1 |
| Garlock, GL; Jivraj, S; Stapleton, SR; Wagle, A | 1 |
| Alexander, JS; Kevil, CG; Mire, E; Payne, DK | 1 |
| Bilney, AJ; Hartfield, PJ; Murray, AW | 1 |
| Daly, RJ; Fiddes, RJ; Janes, PW; Musgrove, EA; Sivertsen, SP; Sutherland, RL | 1 |
| Krantz, SB; Sui, X; You, M; Zhao, Z | 1 |
| Feldman, EL; Kim, B | 1 |
| Begum, N; Duddy, N; McCarthy, M; Ragolia, L; Rienzie, J | 1 |
| Agazie, YM; Halenda, SP; Kaufman, R; Wilden, PA | 1 |
| Klip, A; Somwar, R; Sumitani, S; Sweeney, G; Taha, C | 1 |
| Birchmeier, W; Brinkmann, V; Hartmann, G; Naundorf, H; Niemann, C; Sachs, M; Spitzer, E | 1 |
| Anand-Srivastava, MB; Ge, C | 1 |
| Nie, M; Selbie, LA | 1 |
| Carter-Su, C; Guan, K; Hodge, C; Liao, J; Schwartz, J; Stofega, M | 1 |
| Cheng, HL; Feldman, EL; Kim, B; Margolis, B | 1 |
| Suzuki, N; Tamanoi, F; Urano, J | 1 |
| Bracke, M; Coffer, PJ; Koenderman, L; Lammers, JW | 1 |
| Boulay, F; Christophe, T; Milcent, MD; Rabiet, MJ; Tardif, M | 1 |
| Eyers, PA; Hundal, HS; McDowell, HE | 1 |
| Inoue, K; Iwasaki, Y; Mutsuga, N; Niiori-Onishi, A; Oiso, Y; Saito, H | 1 |
| Blackshear, PJ; Myers, MG; Pitterle, DM; Sperling, RT; White, MF | 1 |
| Horiuchi, N; Kawane, T | 1 |
| Hecht, SS; Iijima, K; Jyonouchi, H; Sun, S; Wang, M | 1 |
| Allen, MP; Basilico, C; Bellosta, P; Heidenreich, KA; Meintzer, MK; Schneider, K; Varnum, B; Wierman, ME; Xiong, X; Zeng, C | 1 |
| Chayama, K; Gelfand, EW; Hamelmann, E; Ishizuka, T; Johnson, GL; Keller, GM; Takeda, K; Terada, N | 1 |
| Baccarini, M; Kovarik, P; Procyk, KJ; von Gabain, A | 1 |
| Hinoue, T; Kidd, M; Läuffer, JM; Modlin, IM; Schmid, SW; Tang, LH; Zhang, T | 1 |
| Ekinci, FJ; Shea, TB | 1 |
| Almazan, G; Larocca, JN; Liu, HN | 1 |
| Adayev, T; Banerjee, P; Barua, M; El-Sherif, Y; Penington, NJ | 1 |
| Hajjar, DP; Muller, WA; Rosengart, TK; Thakker, GD | 1 |
| Endo, Y; Hatanaka, H; Lindholm, D; Takei, N; Tanaka, O | 1 |
| Furukawa, M; Kojima, I; Nie, L; Shibata, H; Zhang, YQ | 1 |
| Shibuya, M; Takahashi, T; Ueno, H | 1 |
| Piper, HM; Schäfer, M; Schlüter, KD; Simm, A; Taimor, G | 1 |
| Hiraguri, M; Iwamoto, I; Kurasawa, K; Miike, S; Nakao, A; Saito, Y | 1 |
| Benedetti, A; Casini, A; Di Sario, A; Folli, F; Gaggiotti, G; Macarri, G; Marucci, L; Orlandoni, P; Perego, L; Ridolfi, F; Svegliati-Baroni, G | 1 |
| Schrör, K; Weber, AA; Zucker, TP | 1 |
| Anderson, SM; Gibson, S; Johnson, GL; Oyer, R; Tu, S | 1 |
| Fukunaga, K; Kanasaki, H; Miyamoto, E; Miyazaki, K; Takahashi, K | 1 |
| Gwag, BJ; Jou, I; Ko, HW; Noh, JS; Ryu, BR | 1 |
| Perkinton, MS; Sihra, TS; Williams, RJ | 1 |
| Ahn, BK; Chung, BS; Do, IR; Jhun, BH; Kang, CD; Kim, KW; Kim, SH; Yoo, MA | 1 |
| Haruta, T; Ishihara, H; Ishiki, M; Kobayashi, M; Sasaoka, T; Takata, Y; Usui, I; Wada, T | 1 |
| Abedi, H; Cospedal, R; Zachary, I | 1 |
| Beier, F; LuValle, P | 1 |
| Ai, W; Gong, J; Yu, L | 1 |
| Clemmons, DR; Imai, Y | 1 |
| Bussolati, O; Dall'Asta, V; Franchi-Gazzola, R; Gazzola, GC; Visigalli, R | 1 |
| Calvo, J; Cid, MC; Esparza, J; Juan, M; Urbano-Márquez, A; Vilardell, C; Vives, J; Yagüe, J | 1 |
| Goodyear, LJ; Jakobsen, AB; Lynge, J; Richter, EA; Wojtaszewski, JF | 1 |
| Bandyopadhyay, G; Burke, TR; Farese, RV; Quon, MJ; Sajan, MP; Standaert, ML | 1 |
| Brandt, SJ; Koury, MJ; Prasad, KS; Tang, T | 1 |
| Kobayashi, T; Michikawa, M; Mizusawa, H; Muramatsu, H; Muramatsu, T; Owada, K; Sanjo, N | 1 |
| Chan, JS; Chen, X; Filep, JG; Ingelfinger, JR; Tang, SS; Zhang, SL | 1 |
| Cohen, P; Shaw, M | 1 |
| Sotsios, Y; Ward, SG; Westwick, J; Whittaker, GC | 1 |
| Carlsen, J; Christiansen, K; Grunnet, N; Vinten, J | 1 |
| Novak, RF; Woodcroft, KJ | 1 |
| Fujita, Y; Hirasawa, N; Ohuchi, K; Sato, Y | 1 |
| Berti, L; Gammeltoft, S | 1 |
| Arase, Y; Hasegawa, R; Hiwasa, T; Ito, H; Nomura, J; Suzuki, N | 1 |
| Fukunaga, K; Miyamoto, E; Miyazaki, K; Munir, I; Okamura, H | 1 |
| Côté, S; Gingras, S; Simard, J | 1 |
| Bar-Peled, O; Bristol, LA; Coccia, C; Griffin, JW; Ho, TW; Jin, L; Johnson, E; Li, Y; Milbrandt, J; Rothstein, JD | 1 |
| Gentilini, A; Gentilini, P; Marra, F; Pinzani, M | 1 |
| Huper, G; Iglehart, JD; Lobenhofer, EK; Marks, JR | 1 |
| Alessi, DR; Bertrand, L; Deprez, J; Hue, L; Krause, U; Rider, MH | 1 |
| Aisaki, Ki; Ikawa, Y; Matsuzaki, T; Noda, M; Yamamura, Y | 1 |
| Cadilla, CL; Jimenez, BD; Longo, N; Meléndez, PA | 1 |
| Chang, C; Hu, C; Leu, CM | 1 |
| Fleck, E; Goetze, S; Hsueh, WA; Kawano, H; Kawano, Y; Kintscher, U; Law, RE; Wakino, S | 1 |
| Filippa, N; Giorgetti-Peraldi, S; Miele, C; Rochford, JJ; Van Obberghen, E | 1 |
| Fleischmann, M; Iynedjian, PB | 1 |
| Dickenson, JM; Germack, R | 2 |
| Bernier, SG; Haldar, S; Michel, T | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Baumgarten, CM; Dent, P; Fan, S; Gao, B; He, L; Kunos, G; Nguyen, VA; Sheng, X; Spector, M; Woodward, J | 1 |
| Baserga, R; Bossi, G; Cristofanelli, B; Dews, M; Marchetti, A; Morena, AR; Rizzo, MG; Sacchi, A; Soddu, S; Valentinis, B | 1 |
| Krantz, SB; Sui, X; Zhao, ZJ | 1 |
| Böhm, M; Geisler, M; Mies, F; Nohr, T; Schnabel, P | 1 |
| Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Sasaoka, T; Takano, A; Ueno, E; Uno, T; Usui, I | 1 |
| Pelling, JC; Persons, DL; Yazlovitskaya, EM | 1 |
| Kar, S; Quirion, R; Zheng, WH | 1 |
| Fukuda, K; Kato, T; Kodama, H; Makino, S; Manabe, T; Murata, M; Ogawa, S; Pan, J; Sano, M; Takahashi, T | 1 |
| Adrian, TE; Ding, XZ; Fehsenfeld, DM; Murphy, LO; Permert, J | 1 |
| Khandelwal, RL; Syed, NA | 1 |
| Boos, MD; Chini, CC; Dick, CJ; Leibson, PJ; Schoon, RA | 1 |
| Chan, JL; Nguyen, KT; Wang, LH; Wang, WJ | 1 |
| Lee, J; Mira-Arbibe, L; Ulevitch, RJ | 1 |
| Ballesteros, M; Doyle, N; Ho, KK; Leung, KC; Waters, MJ | 1 |
| Annunziato, F; Bonacchi, A; Efsen, E; Francalanci, M; Gentilini, P; Laffi, G; Lasagni, L; Marra, F; Pinzani, M; Romagnani, P; Romanelli, RG; Serio, M | 1 |
| Chen, CS; Dods, P; Gagnon, A; Roustan-Delatour, N; Sorisky, A | 1 |
| Baldacci, G; Pizon, V | 1 |
| Kobayashi, H; Mizisin, AP | 1 |
| Byrne, R; Hamilton, JA; Jessup, W; Kanagasundaram, V; Whitty, G | 1 |
| Aragona, F; Malendowicz, LK; Nussdorfer, GG; Rebuffat, P; Tortorella, C | 1 |
| Carrillo, JJ; Esteban-Gamboa, A; Felíu, JE; Ibares, B | 1 |
| Aoki, M; Horiuchi, M; Kaneda, Y; Matsumoto, K; Morishita, R; Nakagami, H; Nakamura, T; Ogihara, T; Taniyama, Y; Yamamoto, K | 1 |
| Chaudhary, LR; Hruska, KA | 1 |
| Chesterman, CN; Gousseva, N; Khachigian, LM; Kugathasan, K | 1 |
| Sun, HY; Zhao, RR; Zhi, JM | 1 |
| Asahi, KI; Honma, Y; Ishii, Y; Tomoyasu, S; Yamada, K; Yamamoto-Yamaguchi, Y | 1 |
| de Villiers, EM; Ruhland, A | 1 |
| Bode, AM; Chen, N; Dong, Z; Nomura, M; Zhang, Y; Zhong, S | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Shyr, MH; Wang, CC; Yang, CM | 1 |
| Chang, LC; Wang, JP | 1 |
| Cruise, L; Fuller, G; Ho, LK; Morris, BJ; Veitch, K | 1 |
| Byrnes, HD; Fine, JS; Hipkin, RW; Zavodny, PJ | 1 |
| Buridi, A; Coxon, PY; Kettritz, R; Klein, JB; Manning, T; McLeish, KR; Rane, MJ | 1 |
| Hibi, M; Hirano, T; Kanada, H; Kojima, H; Nagasawa, T; Shimizu, S; Shinagawa, A | 1 |
| Chen, KY; Chiu, SL; Hsu, HY; Hua, KF; Wen, MH | 1 |
| Claes, P; Grobben, B; Roymans, D; Slegers, H | 1 |
| Esch, GL; Harada, S; Holgado-Madruga, M; Wong, AJ | 1 |
| Combes, P; Crumiere, M; Dickenson, JM; Graham, S; Klotz, KN | 1 |
| Adamchik, Y; Baskys, A | 1 |
| Inanami, O; Kuwabara, M; Tsuji, M | 1 |
| Antonetti, DA; Barber, AJ; Gardner, TW; Nakamura, M; Reiter, CE; Seigel, GM; Wolpert, EB | 1 |
| Bazan, HE; Chandrasekher, G; Kakazu, AH | 1 |
| Bandyopadhyay, G; Dikic, I; Farese, RV; Kanoh, Y; Quon, MJ; Reed, BC; Sajan, MP; Standaert, ML | 2 |
| Amin, AR; Hamaguchi, M; Ichigotani, Y; Kikkawa, F; Nawa, A; Sein, TT; Thant, AA; Zhang, Y | 1 |
| Dobashi, K; Ichimonji, I; Iizuka, K; Ishiwara, M; Ishizuka, T; Kawata, T; Mori, M; Nakazawa, T; Okajima, F; Tsukagoshi, H | 1 |
| Amiot, M; Barillé, S; Bataille, R; Collette, M; Mellerin, MP; Puthier, D; Thabard, W | 1 |
| Delehedde, M; Fernig, DG; Lyon, M; Rudland, PS; Sergeant, N | 1 |
| Franco, R; Pasantes-Morales, H; Torres-Márquez, ME | 1 |
| Bocciardi, R; Bourget, I; Busca, R; Farahi-Far, D; Juhel, T; Mograbi, B; Rochet, N; Rossi, B | 1 |
| Låg, M; Refsnes, M; Schwarze, PE; Thoresen, GH; Thrane, EV | 1 |
| Bai, G; Kusiak, JW; Liu, A; Mei, L; Norton, DD; Prenger, MS | 1 |
| Corwin, JT; Montcouquiol, M; Witte, MC | 1 |
| Badwey, JA; Crossley, L; De Mesquita, DD; Zhan, Q | 1 |
| Bucana, CD; Ellis, LM; Gallick, GE; Jung, YD; McConkey, DJ; McMahon, G; Solorzano, CC | 1 |
| Pouysségur, J; Viñals, F | 1 |
| García-García, E; Rosales, C; Sánchez-Mejorada, G | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Lynch, OT | 1 |
| Bisotto, S; Fixman, ED | 1 |
| Crawford, JM; Sautin, YY; Svetlov, SI | 1 |
| Brunelleschi, S; Colangelo, D; Gaudino, G; Lavagno, L; Penengo, L; Santoro, C; Viano, I | 1 |
| Goodchild, AK; Pilowsky, PM; Seyedabadi, M | 1 |
| Bode, AM; Dong, Z; Liu, G; Ma, WY; Zhang, Y | 1 |
| Kandolf, R; Küpper, JH; Meyer, RG; Rodemann, HP | 1 |
| Gera, J; Hsu, JH; Hu, L; Lichtenstein, A; Shi, Y | 1 |
| Betti, M; Canesi, L; Ciacci, C; Citterio, B; Gallo, G; Pruzzo, C; Scarpato, A | 1 |
| Cederberg, A; Enerbäck, S; Grønning, LM; Miura, N; Taskén, K | 1 |
| Hayashi, K; Kadomatsu, K; Muramatsu, T | 1 |
| Li, YL; Li, ZY; Ma, KL; Tsui, ZC; Zou, W | 1 |
| Chan, JS; Chen, X; Filep, JG; Hohman, TC; Pang, L; To, C; Wang, TT; Wu, XH; Zhang, SL | 1 |
| Cohen, P; Peggie, M; Prescott, AR; Rena, G; Unterman, TG; Williams, MR; Woods, YL | 1 |
| Andrés, A; Carrascosa, JM; Fermín, Y; Martínez, C; Molero, JC; Pérez, C; Villar, M | 1 |
| Aizawa, T; Hashizume, K; Iijima, S; Nakajima, K; Shigematsu, S; Yamauchi, K | 1 |
| Bell, RM; Mocanu, MM; Yellon, DM | 1 |
| Cruciani, V; Mikalsen, SO | 1 |
| Dryer, SE; Lhuillier, L | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Klejman, A; Morrione, A; Rushen, L; Skorski, T; Slupianek, A | 1 |
| Block, ER; Li, YD; Patel, JM | 1 |
| Bertics, PJ; Dam, P; Kim, YN | 1 |
| Mann, GE; Morgan, AJ; Pearson, JD; Sobrevia, L; Steinert, JR; Sugden, D; Wheeler-Jones, CP; Wyatt, AW | 1 |
| Bezombes, C; Demur, C; Filomenko, R; Hernandez, H; Jaffrézou, JP; Laurent, G; Maestre, N; Mas, VM; Plo, I; Quillet-Mary, A | 1 |
| Bungenstock, A; Czupalla, C; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Nürnberg, B; Spencer-Hänsch, C; Stawowy, P | 1 |
| Bhatt, NY; Clanton, TL; Kelley, TW; Khramtsov, VV; Lam, GK; Marsh, CB; Wang, Y | 1 |
| Andreeff, M; Bondar, VM; McConkey, DJ; Mills, GB; Sweeney-Gotsch, B | 1 |
| Eggo, MC; Holder, JC; Kumar, S; Patel, NG; Smith, SA | 1 |
| Arai, H; Baik, YH; Choi, BS; Doi, K; Hwang, TJ; Itoh, H; Kim, KK; Kook, H; Nakao, K; Sawada, N | 1 |
| Bargou, R; Dörken, B; Gries, M; Janz, M; Lentzsch, S; Mapara, MY | 1 |
| Greenberg, DA; Jin, K; Mao, XO; Zhu, Y | 1 |
| Gadsby, JE; Ge, Z; Hedgpeth, V; Miller, EA | 1 |
| Brodt, P; Zhang, D | 1 |
| Najib, S; Sánchez-Margalet, V | 1 |
| Cohen, P; Francis, MJ; Moore, MG; Peehl, DM; Wetterau, LA | 1 |
| Andriantsitohaina, R; Beretz, A; Chang, SJ; Chataigneau, M; Chataigneau, T; Keravis, T; Oak, MH; Schini-Kerth, VB; Stoclet, JC | 1 |
| Blanquet, PR; Derer, P; Mariani, J | 1 |
| Bukczynska, P; Klingler-Hoffmann, M; Tiganis, T | 1 |
| López, HS; Mascó, DH; Salvarezza, SB | 1 |
| Fan, TP; Gherardi, E; Li, RC; Sasisekharan, R; Sellers, LA; Sengupta, S; Watson, N; Zhao, G | 1 |
| Cho, H; Kim, DK; Lee, MO; Lee, N; Oh, SH; Park, ES; Park, H; Seong, JK; Yoo, YG; Yu, DY | 1 |
| Baldwin, J; Bousquet, P; Chen, M; Dontenwill, M; Dupuy, L; Greney, H; Pascal, G; Piletz, JE; Rondé, P; Takeda, K; Urosevic, D | 1 |
| Cattaneo, MG; Pola, S; Vicentini, LM | 1 |
| Farnell, MB; Genovese, K; He, H; Kogut, MH | 1 |
| Coppens, A; Hooghe-Peters, E; Kooijman, R | 1 |
| Agrawal, DK; DelCore, MG; Hunter, WJ; Krueger, KD | 1 |
| Burt, HM; Hampong, M; Higo, TT; Jackson, JK; Pelech, SL; Tudan, C | 1 |
| Barrett, KE; Bertelsen, LS; Keely, SJ | 1 |
| Chen, JX; Meyrick, B | 1 |
| Hashimoto, T; Huey, M; Yang, GY; Yao, JS; Young, WL | 1 |
| Khaibullina, AA; Krum, JM; Rosenstein, JM | 1 |
| Chihara, K; Iida, K; Kaji, H; Matsuo, M; Okimura, Y; Takahashi, Y; Yoshioka, S | 1 |
| Bar-Eli, M; Brodt, P; Meloche, S; Zhang, D | 1 |
| Cohen, MV; Cui, L; Downey, JM; Krieg, T; Yang, XM | 1 |
| Acitores, A; González, N; Sancho, V; Valverde, I; Villanueva-Peñacarrillo, ML | 2 |
| Garnovskaya, MN; Grewal, JS; Mukhin, YV; Raymond, JR; Tholanikunnel, BG; Ullian, ME; Vlasova, TM | 1 |
| Han, HJ; Nickerson, PA; Sigurdson, WJ; Taub, M | 1 |
| Fujii, K; Fukuhara, M; Iida, M; Lin, Y; Matsumura, K; Tsuchihashi, T | 1 |
| Slomiany, A; Slomiany, BL | 4 |
| Chan, JS; Filep, JG; József, L; Khreiss, T | 1 |
| Draznin, B; Gurerich, I; Leitner, JW; Nadeau, KJ | 1 |
| Ariga, H; Matsumoto, K; Minamitani, T; Orba, Y; Sato, M; Sawa, H | 1 |
| Allen, WE; Campbell, M; Sawyer, C; Trimble, ER; Vanhaesebroeck, B | 1 |
| Aguilera, J; Chaïb-Oukadour, I; Gil, C | 1 |
| Brodmann, M; Egger, M; Eisterer, W; Fischer-Colbrie, R; Frauscher, S; Hanley, A; Kirchmair, R; Losordo, DW; Murayama, T; Nagl, M; Niederwanger, A; Patsch, JR; Pedrini, M; Schratzberger, P; Silver, M; Sturm, W; Walter, DH; Woell, E | 1 |
| Franklin, JL; Keeton, AB; Messina, JL; Xu, J | 1 |
| Chiou, WF; Tsai, HR; Tsai, WJ; Yang, LM | 1 |
| Delpiano, AM; Hitschfeld, C; Lavandero, S; Lobos, L; Marusic, ET; Michea, L | 1 |
| Hamburger, M; Riese, U; Ziegler, E | 1 |
| Chang, EJ; Chung, CP; Huh, JE; Kim, HH; Kim, HM; Kim, IA; Seung Ko, J | 1 |
| Li, W; Sumpio, BE | 1 |
| Fan, GH; Watson, K | 1 |
| Cho, ML; Kim, HY; Kim, KW; Lee, SH; Park, MK; Park, SH; Yoon, CH | 1 |
| Adachi, Y; Gabazza, EC; Hori, Y; Katsuki, A; Morioka, K; Nakatani, K; Nobori, T; Sumida, Y; Yano, Y | 1 |
| Ito, T; Kitamura, H; Okudela, K; Udaka, N; Wang, J; Yazawa, T | 1 |
| Davies, MG; Fegley, AJ; Kim, D; Nicholl, SM; Roztocil, E; Tanski, WJ | 1 |
| Andera, L; Cermak, L; Drosopoulos, KG; Pintzas, A; Roberts, ML; Sasazuki, T; Shirasawa, S | 1 |
| Auberger, P; Brambilla, C; Coll, JL; Dubrez-Daloz, L; Favrot, MC; Hurbin, A; Mari, B | 1 |
| Harris, DC; Hoe, HS; Rebeck, GW | 1 |
| Kim, SH; Kim, TS; Oh, SM | 1 |
| Chao, W; Novikov, M; Rosenzweig, A; Schmidt, U; Shen, Y; Zhao, H; Zhu, X | 1 |
| Hanley, S; Jamal, AM; Laganière, S; Lipsett, M; Rosenberg, L; Sladek, R | 1 |
| Bifulco, K; Campiglia, P; Carriero, MV; Franco, P; Gargiulo, L; Grieco, P; Longanesi-Cattani, I; Peluso, G; Raiola, R; Stoppelli, MP | 1 |
| Evers, BM; Rychahou, PG; Saito, H; Uchida, T; Watanabe, H | 1 |
| Iso, T; Kanai, H; Kurabayashi, M; Nagai, R; Ohyama, Y; Sakamoto, H; Sato, H; Sato, M; Tamura, J; Uchiyama, T | 1 |
| Chang, YC; Hsu, JD; Huang, HP; Wang, CJ; Yang, SF | 1 |
| Dietzmann, K; Firsching, R; Grimm, C; Kirches, E; Kropf, S; Lendeckel, U; Mawrin, C; Pambor, C; Sasse, T; Schneider, T; Vorwerk, CK | 1 |
| Adragna, NC; Lauf, PK; Zhang, J | 1 |
| Gilbert, AK; Pétrin, D; Rola-Pleszczynski, M; Stankova, J; Turcotte, S | 1 |
| Ikejima, T; Liu, YQ; Onodera, S; Tashiro, S; You, S | 1 |
| Collman, RG; Freedman, BD; Lee, C; Tomkowicz, B | 1 |
| Bösser, S; Oehme, I; Zörnig, M | 1 |
| Adrian, TE; Bell, RH; Ding, XZ; Talamonti, MS; Tong, WG | 1 |
| Tang, LL; Tang, XC; Wang, R | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Bassetti, CL; Gassmann, M; Hermann, DM; Kilic, E; Kilic, U; Soliz, J | 1 |
| Andò, S; Bonofiglio, D; Maggiolini, M; Musti, AM; Picard, D; Recchia, AG; Vivacqua, A | 1 |
| Bando, H; Hori, Y; Ikuno, Y; Sayanagi, K; Tano, Y | 1 |
| Jo, EK; Jung, SB; Kim, HJ; Lee, JS; Oh, JH; Paik, TH; Park, JK; Song, CH; Yang, CS | 1 |
| Bravo-Zehnder, M; Bull, P; Cáceres, M; Cárcamo, C; González, A; Jacobelli, S; Martínez, J; Massardo, L; Oyanadel, C; Pardo, E; Soza, A | 1 |
| Alvarez, ME; Ceballos, A; Coso, OA; Gamberale, R; Geffner, J; Martínez, D; Sabatté, J; Salamone, G; Tanos, T; Trevani, A; Vermeulen, M | 1 |
| Fulton, D; Kotanidou, A; Papapetropoulos, A; Roussos, C; Tsigkos, S; Zakynthinos, S; Zhou, Z | 1 |
| Dum, N; Gerwien, J; Poulsen, LK; Sha, Q; Skov, PS | 1 |
| Bodyak, N; He, Z; Izumo, S; Kahn, CR; Kang, PM; King, GL; Kulkarni, RN; Liao, R; Opland, DM; Ueki, K; Wang, B; Way, KJ | 1 |
| Duleba, AJ; Foyouzi, N; Kwintkiewicz, J; Pehlivan, T; Spaczynski, RZ | 1 |
| Blume, N; Friedrichsen, BN; Gram, VK; Lee, YC; Møldrup, A; Neubauer, N; Nielsen, JH; Petersen, JS | 1 |
| Chen, HL; Liu, SQ; Lv, P; Yu, HG; Yu, JP | 1 |
| Cicha, I; Goppelt-Struebe, M; Graness, A | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Han, JW; Kang, DW; Kim, SN; Kim, YK; Lee, HY; Seo, DW | 1 |
| Anand-Srivastava, MB; Hashim, S; Li, Y | 2 |
| Hanai, Y; Kozawa, O; Takai, S; Tokuda, H | 2 |
| Duarte, AI; Oliveira, CR; Proença, T; Rego, AC; Santos, MS | 1 |
| Adamczyk, J; Fischer, I; Gabryel, B; Malecki, A; Pudelko, A | 1 |
| Axelson, M; Carlsson-Skwirut, C; Colón, E; Larsson, O; Söder, O; Svechnikov, KV; Zaman, F | 1 |
| Saisho, H; Tomizawa, M | 1 |
| Bell, RM; Clark, JE; Hearse, DJ; Shattock, MJ | 1 |
| Agrawal, DK; Cheng, G; Jia, G; Kim, MJ | 1 |
| Akishita, M; Eto, M; Kaneko, A; Okabe, T; Ouchi, Y; Yu, J | 1 |
| Fischoeder, A; Fleck, E; Graf, K; Meyborg, H; Stawowy, P; Stibenz, D | 1 |
| Goalstone, ML; Sharma, G | 1 |
| Busacca, M; Di Blasio, AM; Di Francesco, S; Gentilini, D; Viganò, P; Vignali, M | 1 |
| Li, X; Li, Y; Lin, S; Song, YH; Yu, X; Zhang, S | 1 |
| Kimura, M; Ogihara, M; Okamoto, H | 1 |
| Durston, M; Massaeli, H; Mesaeli, N; Wu, M | 1 |
| Chiou, WF; Don, MJ; Liao, JF; Lin, LY | 1 |
| Seidler, U; Tuo, BG; Wen, GR | 1 |
| Cigorraga, SB; Galardo, MN; Meroni, SB; Pellizzari, EH; Riera, MF | 1 |
| Baldacci, C; Caruso, A; Flamini, MI; Fu, XD; Garibaldi, S; Genazzani, AR; Giretti, MS; Mannella, P; Sanchez, AM; Simoncini, T | 1 |
| Cooke, PS; Ekman, GC; Hess, RA; Murphy, KM; Simon, L; Tyagi, G | 1 |
| Chung, H; Moon, M; Park, S; Seo, S | 2 |
| Kersten, JR; Krolikowski, JG; Pagel, PS; Pratt, PF; Shim, YH; Venkatapuram, S; Warltier, DC; Weihrauch, D | 1 |
| Chen, SG; Cui, Q; Ikejima, T; Li, D; Onodera, S; Tashiro, S; Wu, LJ | 1 |
| Gómez, R; Gomez-Reino, JJ; Gualillo, O; Lago, F; Lago, R; Otero, M | 1 |
| Barrett, EJ; Liu, Z; Wang, AX; Wang, H | 1 |
| Arino, T; Kawahara, Y; Maki, T; Takagi, N; Takeo, S; Tanonaka, K; Yagi, A | 1 |
| Avissar, NE; Sax, HC; Toia, L | 1 |
| Li, JC; Yang, Z | 1 |
| Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW | 1 |
| Ganapathy, V; Kashiwagi, H; Sugawara, M; Takekuma, Y; Yamazaki, K | 1 |
| Kim, DY; Kim, JY; Ro, JY | 1 |
| Chung, KY; Dayton, WR; Hathaway, MR; Johnson, BJ; Kamanga-Sollo, E; White, ME | 1 |
| Bae, YS; Im, DS; Jo, SH; Kim, JM; Kim, SD; Lee, HY; Lee, SY; Shim, JW; Yun, J | 1 |
| Bertone, C; Bianco, MJ; Brama, M; Castelli, A; Rossi, F; Santiemma, V | 1 |
| Calvo, JC; Dueñas, JL; Maymó, JL; Pérez Pérez, A; Sánchez-Margalet, V; Varone, CL | 1 |
| Aslanidis, C; Buechler, C; Gerl, M; Gindner, A; Neumeier, M; Schäffler, A; Schölmerich, J; Wanninger, J; Weigert, J; Wurm, S | 1 |
| Ding, L; Guo, B; Huang, J; Qiu, L; Wang, D; Zhang, J | 1 |
| Brighente, IM; Cazarolli, LH; Folador, P; Moresco, HH; Pizzolatti, MG; Silva, FR | 1 |
| Franke, H; Hengstler, JG; Illes, P; Krügel, U; Rudolph, C; Sauer, C | 1 |
| Kim, DS; Shim, JW; Shim, JY; Shin, JH | 1 |
| Chauhan, P; Shrivastava, A; Sodhi, A | 1 |
| Cotero, VE; Routh, VH | 1 |
| Adolfo García-Sáinz, J; Alcántara-Hernández, R | 1 |
| Hashimoto, K; Hirato, J; Horiguchi, K; Mori, M; Satoh, T; Tosaka, M; Yamada, M; Yamada, S | 1 |
| Cazarolli, LH; Folador, P; Mena Barreto Silva, FR; Pizzolatti, MG | 1 |
| Lu, LQ; Ma, LQ; Tang, CS; Wang, HX; Zeng, XJ; Zhang, LK | 1 |
| Dueñas, JL; Gambino, Y; Goberna, R; Maymó, J; Pérez-Pérez, A; Sánchez-Margalet, V; Varone, C | 1 |
| Balbo, V; Boccafoschi, F; Burlando, B; Mazzucco, L; Ranzato, E | 1 |
| Lacerda, L; Lecour, S; Opie, LH; Somers, S | 1 |
| Hong, BZ; Kang, HS; Kim, HG; Kim, HN; Kwak, YG; Ma, TZ; Park, SA | 1 |
| Jeon, YT; Kim, SH; Kim, YB; Lee, SC; Song, YS | 1 |
| Choe, J; Chung, BH; Ha, KS; Jeoung, D; Kim, JD; Kim, YM; Kwon, YG; Lee, H; Lee, JJ | 1 |
| Barrett, KE; Hoda, MR; Keely, SJ; McCole, DF; Scharl, M | 1 |
| Hashimoto, R; Koizumi, H; Okabe, T; Ouchi, Y; Yu, J | 1 |
| Hazeki, K; Hazeki, O; Izumi, T; Nigorikawa, K; Okazaki, N | 1 |
| Kitsiouli, E; Lekka, ME; Letsiou, E; Nakos, G | 1 |
| Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S | 1 |
| Batistela, AP; Carvalho, TT; Cunha, FQ; Cunha, TM; Ferreira, SH; Flauzino, T; Otaguiri, ES; Verri, WA; Zarpelon, AC | 1 |
| Hsu, CK; Lee, CY; Li, SC; Liao, HF; Lin, TJ; Su, YC; Yu, CC | 1 |
| Kreydiyyeh, SI; Serhan, MF | 1 |
| De Caterina, R; Geng, YJ; Glatz, JF; Madonna, R; Salerni, S; Schiavone, D | 1 |
| Abdel-Rahman, AA; Ibrahim, BM | 1 |
| Li, X; Sun, F; Tang, Y; Yin, S; Zhou, X; Zhou, Y | 1 |
| Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Pavao-de-Souza, GF; Sanson, JS; Tedeschi, GC; Verri, WA; Zarpelon, AC | 1 |
| Oliveira, SH; Santos, VA | 1 |
| Guo, X; Jin, X; Li, L; Sun, W; Wang, Y; Xu, RC; Zhang, X | 1 |
| Gibson, JS; Milner, PI; Robinson, R; Smith, HC; Wilkins, RJ | 1 |
| Deng, XL; Li, GR; Su, XL; Wang, Y; Zhao, LM | 1 |
| Chao, CY; Chen, HW; Li, CC; Lii, CK; Lin, LL; Liu, KL; Lu, CY | 1 |
| Aparicio, C; González, N; Jensen, RT; Mantey, SA; Martín-Duce, A; Moreno-Villegas, Z; Portal-Núñez, S; Ramos-Álvarez, I; Sanz, R | 1 |
| Chang, CD; Chang, CI; Hsu, JL; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL | 1 |
| Affabris, E; Borgatti, M; De Vito, P; Gambari, R; Incerpi, S; Luly, P; Pedersen, JZ; Percario, Z | 1 |
| Fujii, H; Izawa, S; Kiessling, R; Kono, K; Kua, LF; Mimura, K; Mueller, A; Seliger, B; Shiraishi, K; So, J; Yong, WP | 1 |
| Chang, HH; Huang, YM; Juan, CC; Kao, CC; Kao, YH; Kuo, YC; Liu, CW; Tang, YC | 1 |
| Anada, T; Ishiko-Uzuka, R; Nishikawa, R; Suzuki, O | 1 |
| Li, B; Li, S; Qiu, T; Wang, X; Yin, Y; Zhang, P | 1 |
| Abdel-Rahman, AA; Penumarti, A | 1 |
| Fu, D; Ji, L; Li, R; Liang, X; Liu, F; Tie, R; Wang, W; Xing, W; Zhang, H | 1 |
| Kockar, F; Tokay, E | 1 |
| Wan, J; Wu, W | 1 |
| Archambault, E; Cynober, L; Goron, A; Guihenneuc, C; Jourdan, M; Le Plénier, S; Moinard, C; Neveux, N; Salles, J; Sotiropoulos, A; Walrand, S | 1 |
| Chen, HX; Tan, BZ; Xu, XX; Zhang, Z; Zhou, XD | 1 |
| Chen, LM; Guo, X; Ma, ZJ; Pan, CQ; Sun, B; Wang, Y; Zhang, XN | 1 |
| Ayala, TS; Bella, LM; Martins, JO; Nolasco, EL; Tessaro, FHG | 1 |
| Kira, Y; Mizukami, Y; Sugawara, K; Tsuruta, D | 1 |
| Liu, ZX; Luo, WW; Ma, D; Ma, SM; Su, Q; Sun, Y; Wang, CY; Wen, JK; Yang, YZ; Yang, Z; Zhang, XH; Zheng, B | 1 |
| Fujita, S; Inui, T; Kobayashi, M; Murayama, S; Ogiso, B; Takei, H; Yamamoto, K | 1 |
| Chang, HN; Chueh, HY; Pang, JS; Yeh, YC | 1 |
| Burd, MA; Peterson, DG; Strong, ME | 1 |
1 review(s) available for pd 98059 and wortmannin
| Article | Year |
|---|---|
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
1 trial(s) available for pd 98059 and wortmannin
| Article | Year |
|---|---|
G-CSF downregulates natural killer cell-mediated cytotoxicity in donors for hematopoietic SCT.
Topics: Adult; Androstadienes; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression Regulation, Enzymologic; Graft vs Host Disease; Graft vs Leukemia Effect; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Immunity, Cellular; K562 Cells; Killer Cells, Natural; Male; Peripheral Blood Stem Cell Transplantation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Tissue Donors; TOR Serine-Threonine Kinases; Triose-Phosphate Isomerase; Wortmannin | 2012 |
378 other study(ies) available for pd 98059 and wortmannin
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin.
Topics: Adipose Tissue; Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose Transporter Type 4; Hexokinase; Insulin; Insulin Antagonists; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Myocardium; Polyenes; Rats; RNA, Messenger; Signal Transduction; Sirolimus; Transcription, Genetic; Wortmannin | 1996 |
Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fructosediphosphates; Glycolysis; In Vitro Techniques; Insulin; Insulin Antagonists; Mitogen-Activated Protein Kinase 1; Models, Biological; Myocardium; Phosphatidylinositol 3-Kinases; Phosphofructokinase-2; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1996 |
Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; DNA; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Kinetics; Mice; Mitogen-Activated Protein Kinase Kinases; Muscle, Skeletal; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase Inhibitors; Recombinant Proteins; Signal Transduction; Wortmannin | 1996 |
Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Virulence Factors, Bordetella; Wortmannin | 1996 |
Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways.
Topics: Androstadienes; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Drug Synergism; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Morpholines; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1997 |
Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Insulin; Muscle, Skeletal; Polyenes; Protein Kinases; Signal Transduction; Sirolimus; Wortmannin | 1996 |
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.
Topics: Androstadienes; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Flavonoids; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases; Saccharomyces cerevisiae Proteins; Signal Transduction; Ultraviolet Rays; Wortmannin | 1997 |
Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases.
Topics: Androstadienes; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemotaxis, Leukocyte; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Wortmannin | 1997 |
Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases.
Topics: 3T3 Cells; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Wortmannin | 1997 |
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1997 |
Wortmannin inhibits IGF-dependent differentiation in the mouse myogenic cell line C2.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Mice; Muscles; Somatomedins; Wortmannin | 1997 |
Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: a novel mechanism of growth hormone receptor regulation.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Enzyme Inhibitors; Flavonoids; Homeostasis; Human Growth Hormone; Humans; Insulin; Insulin-Like Growth Factor I; Kinetics; Osteoblasts; Phospholipases A; Rats; Receptors, Somatotropin; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Trypsin; Wortmannin | 1997 |
An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-I.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cytokines; Enzyme Inhibitors; Flavonoids; GTP Phosphohydrolases; Humans; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; ras Proteins; Signal Transduction; Wortmannin | 1997 |
Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism.
Topics: 3-O-Methylglucose; Adult; Androstadienes; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glycogen Synthase; Humans; Insulin; Male; Mitogen-Activated Protein Kinase 1; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Wortmannin | 1997 |
Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.
Topics: Amino Acid Sequence; Androstadienes; Chromosome Mapping; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 7; Cloning, Molecular; DNA, Complementary; Enzyme Inhibitors; Flavonoids; GRB10 Adaptor Protein; Humans; Insulin; Molecular Sequence Data; Phosphorylation; Protein Binding; Proteins; Receptor, Insulin; Sequence Homology, Amino Acid; Serine; Signal Transduction; src Homology Domains; Wortmannin | 1997 |
NGF exhibits a pro-apoptotic activity for human vascular smooth muscle cells that is inhibited by TGFbeta1.
Topics: Androstadienes; Aorta; Apoptosis; Carbazoles; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Indole Alkaloids; Kinetics; MAP Kinase Kinase Kinase 1; Muscle, Smooth, Vascular; Nerve Growth Factors; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Time Factors; Transforming Growth Factor beta; Wortmannin | 1997 |
Insulin stimulated glycogen synthesis in isolated rat hepatocytes: effect of protein kinase inhibitors.
Topics: Androstadienes; Animals; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Hypoglycemic Agents; Insulin; Liver; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1997 |
Selective modification of insulin action in adipose tissue by hyperthyroidism.
Topics: Adipose Tissue; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Nonesterified; Female; Flavonoids; Glucose; Hyperthyroidism; Insulin; Insulin Antagonists; Lipid Metabolism; Lipolysis; Norepinephrine; Polyenes; Rats; Rats, Wistar; Sirolimus; Triiodothyronine; Wortmannin | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.
Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Cytokines; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Protein Kinases; Respiratory Burst; Signal Transduction; Wortmannin; Zymosan | 1998 |
PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Membrane; Cells, Cultured; Chemotaxis; DNA; Enzyme Inhibitors; Flavonoids; Glomerular Mesangium; Homeostasis; Humans; Kinetics; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Wortmannin | 1997 |
Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts.
Topics: Androstadienes; Animals; Carrier Proteins; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Flavonoids; Insulin; Muscle, Skeletal; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Polyenes; Protein Biosynthesis; Repressor Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1998 |
Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen-activated protein kinase pathway.
Topics: Androstadienes; Bacterial Toxins; Cytochalasin D; Epithelial Cells; Flavonoids; Genistein; Heat-Shock Proteins; HeLa Cells; Hemolysin Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Listeria monocytogenes; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Wortmannin | 1998 |
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Heart; Heart Ventricles; Insulin-Like Growth Factor I; Myocardium; Phosphorylation; Polyenes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Sirolimus; Staurosporine; Wortmannin | 1998 |
Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase.
Topics: Adenoviruses, Human; Androstadienes; Antigens, CD; Catalysis; Cell Adhesion Molecules; Chromones; Cyclosporins; Endocytosis; Enzyme Activation; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin alphaV; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Wortmannin | 1998 |
Bidirectional modulation of insulin action by amino acids.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cells, Cultured; Enzyme Activation; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin; Insulin Receptor Substrate Proteins; Liver; Phosphatidylinositol 3-Kinases; Phosphoproteins; Polyenes; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1998 |
Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.
Topics: Androstadienes; Blood Bactericidal Activity; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Respiratory Burst; Staphylococcus aureus; Thiazoles; Wortmannin | 1998 |
Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin.
Topics: Adipocytes; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Polyunsaturated Alkamides; Protein Prenylation; Proteins; ras Proteins; Receptor, Insulin; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Wortmannin | 1998 |
Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Receptor, Insulin; Receptors, Estrogen; Signal Transduction; Tumor Cells, Cultured; Wortmannin | 1998 |
Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway.
Topics: ADP Ribose Transferases; Androstadienes; Botulinum Toxins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Size; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Humans; Hypotonic Solutions; Indoles; Intestines; Iodine Radioisotopes; Maleimides; Osmotic Pressure; Phosphorylation; ras Proteins; Rubidium Radioisotopes; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Mitogen-activated protein kinase and p70 ribosomal protein S6 kinase are not involved in the insulin-dependent stimulation of cAMP phosphodiesterase kinase in rat adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Amino Acid Sequence; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell-Free System; Chromones; Epidermal Growth Factor; Epididymis; Flavonoids; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Male; Molecular Sequence Data; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Polyenes; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 1998 |
Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; Enzyme Activation; Flavonoids; Glycogen; Humans; Insulin Receptor Substrate Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polyenes; Receptor, Insulin; Ribosomal Protein S6 Kinases; Sirolimus; Tyrosine; Vanadium Compounds; Wortmannin | 1998 |
Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway.
Topics: Acetylcysteine; Androstadienes; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression Regulation; Genes, Immediate-Early; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Nitric Oxide Synthase; PC12 Cells; ras Proteins; Rats; Signal Transduction; Wortmannin | 1998 |
Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I.
Topics: Androstadienes; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Glucose; Humans; Immunohistochemistry; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Wortmannin | 1998 |
Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Flavonoids; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Insulin; Liver; Lovastatin; Male; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Wortmannin | 1998 |
Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins.
Topics: Androstadienes; Antigens, CD; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Membrane Permeability; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Histocytochemistry; Humans; Indoles; Lymphokines; Membrane Proteins; Muscle, Smooth, Vascular; Nitriles; Occludin; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Serum Albumin; Staurosporine; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1998 |
Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.
Topics: Amino Acid Chloromethyl Ketones; Androstadienes; Animals; Apoptosis; Cell Survival; Chromones; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Hypoglycemic Agents; Insulin; Morpholines; Nerve Growth Factors; Neurons; Neuropeptides; Neuroprotective Agents; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Sphingosine; Thionucleotides; Wortmannin | 1998 |
Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle; Cyclin D1; Cyclin-Dependent Kinases; Cyclins; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression; Glycoproteins; Humans; Mitogen-Activated Protein Kinase Kinases; Mitogens; Neuregulin-1; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-myc; Retinoblastoma Protein; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation; Wortmannin | 1998 |
Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Flavonoids; Humans; MAP Kinase Kinase Kinase 1; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Receptors, Erythropoietin; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Stem Cell Factor; Trans-Activators; Wortmannin | 1998 |
Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Chromones; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
Regulation of mitogen-activated protein kinase phosphatase-1 induction by insulin in vascular smooth muscle cells. Evaluation of the role of the nitric oxide signaling pathway and potential defects in hypertension.
Topics: Androstadienes; Animals; Cell Cycle Proteins; Cells, Cultured; Cyclic GMP; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Flavonoids; Imidazoles; Immediate-Early Proteins; Insulin; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Signal Transduction; Wortmannin | 1998 |
ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Chromones; Coronary Vessels; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Signal Transduction; Swine; Wortmannin | 1998 |
Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms.
Topics: Androstadienes; Animals; Cell Line; Chromones; Clone Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Homeostasis; Indoles; Insulin; Kinetics; Maleimides; Models, Biological; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors; Wortmannin | 1998 |
Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.
Topics: Androstadienes; Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Chromones; Enzyme Inhibitors; Flavonoids; Glycoproteins; Hepatocyte Growth Factor; Humans; Mammary Glands, Animal; Mice; Microscopy, Electron; Morphogenesis; Morpholines; Neuregulins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-met; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Wortmannin | 1998 |
Involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in AII-mediated enhanced expression of Gi proteins in vascular smooth muscle cells.
Topics: Androstadienes; Angiotensin II; Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dactinomycin; Embryo, Mammalian; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Protein Biosynthesis; Rats; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Transcription, Genetic; Wortmannin | 1998 |
Neuropeptide Y Y1 and Y2 receptor-mediated stimulation of mitogen-activated protein kinase activity.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Muscle Development; Muscle, Smooth, Vascular; Neuropeptide Y; Peptide YY; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Receptors, Neuropeptide Y; Recombinant Proteins; Transfection; Virulence Factors, Bordetella; Wortmannin | 1998 |
Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.
Topics: 3T3 Cells; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Early Growth Response Protein 1; ets-Domain Protein Elk-1; Flavonoids; Growth Hormone; Immediate-Early Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; ras Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transcription Factors; Transcriptional Activation; Wortmannin | 1998 |
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Cell Membrane; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Models, Biological; Morpholines; Neurites; Neuroblastoma; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Transfection; Tumor Cells, Cultured; Wortmannin | 1998 |
Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells.
Topics: Alkyl and Aryl Transferases; Androstadienes; Animals; Apoptosis; Breast Neoplasms; Caspase 3; Caspases; Cell Line, Transformed; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Flavonoids; Genes, ras; Humans; Indoles; Kidney; Mitochondria; Oligopeptides; Rats; Tumor Cells, Cultured; Wortmannin | 1998 |
Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; Immunoglobulin A; Immunoglobulin G; Interleukin-4; Interleukin-5; Microspheres; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Pyridines; Receptors, Fc; Receptors, IgG; Rosette Formation; Signal Transduction; Th2 Cells; Wortmannin | 1998 |
Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate.
Topics: Androstadienes; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; HL-60 Cells; Humans; Isoenzymes; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neoplasm Proteins; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella; Wortmannin | 1998 |
Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress.
Topics: Amino Acids; Androstadienes; Animals; Arsenites; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hot Temperature; Insulin; Kinetics; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction; Sirolimus; Sodium Compounds; Wortmannin | 1998 |
Molecular mechanisms of the negative effect of insulin-like growth factor-I on growth hormone gene expression in MtT/S somatotroph cells.
Topics: Androstadienes; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Genistein; Growth Hormone; Growth Inhibitors; Insulin; Insulin-Like Growth Factor I; Luciferases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Transfection; Tumor Cells, Cultured; Wortmannin | 1999 |
Early biochemical events in insulin-stimulated fluid phase endocytosis.
Topics: Adipose Tissue, Brown; Androstadienes; Animals; Cell Line; Endocytosis; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, Dominant; Genes, ras; Insulin; Insulin Receptor Substrate Proteins; Mice; Mutation; Phosphoproteins; Receptor Protein-Tyrosine Kinases; Receptor, Insulin; Signal Transduction; Wortmannin | 1999 |
Insulin-like growth factor I suppresses parathyroid hormone (PTH)/PTH-related protein receptor expression via a mitogen-activated protein kinase pathway in UMR-106 osteoblast-like cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Insulin-Like Growth Factor I; Molecular Sequence Data; Osteoblasts; Rats; Receptor, Parathyroid Hormone, Type 1; Receptors, Parathyroid Hormone; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Wortmannin | 1999 |
Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Androstadienes; Anticarcinogenic Agents; Apoptosis; Bronchoalveolar Lavage Fluid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Inositol; L-Lactate Dehydrogenase; Lung; MAP Kinase Kinase 1; Melitten; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Biosynthesis; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Uteroglobin; Wortmannin | 1999 |
Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
Topics: Androstadienes; Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation, Developmental; Gonadotropin-Releasing Hormone; Humans; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Mice; Microscopy, Fluorescence; Neurons; Oncogene Proteins; Precipitin Tests; Proteins; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Sirolimus; Wortmannin | 1999 |
Mitogen-activated protein kinase activation through Fc epsilon receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells.
Topics: Amino Acid Sequence; Androstadienes; Animals; Bone Marrow Cells; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinases; Cyclosporine; Enzyme Activation; Female; Flavonoids; Interleukin-4; JNK Mitogen-Activated Protein Kinases; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Receptor Aggregation; Receptors, IgE; Serotonin; Serotonin Antagonists; Tumor Necrosis Factor-alpha; Wortmannin | 1999 |
Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates.
Topics: Androstadienes; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Flavonoids; Lactams, Macrocyclic; Lipopolysaccharides; Macrophages; Phagocytosis; Phosphatidylinositol 3-Kinases; Phospholipase D; Protein Kinase C; Protein Serine-Threonine Kinases; Quinones; Rifabutin; Salmonella typhimurium; Signal Transduction; Wortmannin | 1999 |
Pituitary adenylate cyclase-activating polypeptide modulates gastric enterochromaffin-like cell proliferation in rats.
Topics: Androstadienes; Animals; Cell Division; Cells, Cultured; Colforsin; DNA; Enterochromaffin Cells; Female; Flavonoids; Gastric Mucosa; Gastrins; Genistein; Humans; Neuropeptides; Neurotransmitter Agents; Octreotide; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Signal Transduction; Terfenadine; Vasoactive Intestinal Peptide; Wortmannin | 1999 |
Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities.
Topics: Alzheimer Disease; Androstadienes; Brain; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Neuroblastoma; Neurons; Phosphorylation; Protein Kinase C; tau Proteins; Tumor Cells, Cultured; Wortmannin | 1999 |
Molecular pathways mediating activation by kainate of mitogen-activated protein kinase in oligodendrocyte progenitors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Animals, Newborn; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; GTP-Binding Proteins; Indoles; Kainic Acid; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligodendroglia; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Signal Transduction; Stem Cells; Tritium; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 1999 |
Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Androstadienes; Animals; Apoptosis; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Flavonoids; Hippocampus; Hypoxia; In Situ Nick-End Labeling; Inositol Phosphates; Membrane Proteins; Mice; Neurons; Oligopeptides; Patch-Clamp Techniques; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Wortmannin | 1999 |
The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling.
Topics: Androstadienes; Cells, Cultured; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Lymphokines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Serum Response Factor; Signal Transduction; Transcription Factors; Transcriptional Activation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways.
Topics: Androstadienes; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Ciliary Neurotrophic Factor; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Flavonoids; Ionomycin; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotrophin 3; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Rats, Wistar; Wortmannin | 1999 |
Role of mitogen-activated protein kinase and phosphoinositide 3-kinase in the differentiation of rat pancreatic AR42J cells induced by hepatocyte growth factor.
Topics: Activins; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Inhibins; Mitogen-Activated Protein Kinase Kinases; Pancreas; Phosphatidylinositol 3-Kinases; Protein Kinases; Protein Tyrosine Phosphatases; Rats; Signal Transduction; Transfection; Wortmannin | 1999 |
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcinogens; Cardiomegaly; Cells, Cultured; Chromones; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Heart Ventricles; Indoles; Isoenzymes; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Wortmannin | 1999 |
Involvement of JAK2, but not PI 3-kinase/Akt and MAP kinase pathways, in anti-apoptotic signals of GM-CSF in human eosinophils.
Topics: Androstadienes; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Eosinophils; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Janus Kinase 2; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrphostins; Wortmannin | 1999 |
Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Collagen; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Insulin-Like Growth Factor I; Kinetics; Liver; Liver Cirrhosis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Receptor, IGF Type 1; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Wortmannin | 1999 |
Platelet surface membranes are highly mitogenic for coronary artery smooth muscle cells--A novel mechanism for sustained proliferation after vessel injury?
Topics: Androstadienes; Animals; Antibodies; Becaplermin; Blood Platelets; Cattle; Cell Division; Cell Membrane; Cells, Cultured; Chlorobenzenes; Coronary Vessels; DNA; Flavonoids; Hot Temperature; Mitogens; Muscle, Smooth, Vascular; Phthalimides; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Sirolimus; Wortmannin | 1999 |
Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation.
Topics: Androstadienes; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; fas Receptor; Flavonoids; Humans; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Wortmannin | 1999 |
Mitogen-activated protein kinase activation by stimulation with thyrotropin-releasing hormone in rat pituitary GH3 cells.
Topics: Androstadienes; Animals; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Hormones; Naphthalenes; Pituitary Neoplasms; Prolactin; Prolactinoma; Rats; Sulfonamides; Thionucleotides; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Wortmannin | 1999 |
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Iron; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Necrosis; Neocortex; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphorylation; Staurosporine; Wortmannin | 1999 |
Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Arachidonic Acid; Benzodiazepines; Benzothiadiazines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Genistein; GTP-Binding Proteins; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, AMPA; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1999 |
Role of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells.
Topics: Androstadienes; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Flavonoids; Humans; K562 Cells; Lactams, Macrocyclic; Leukemia, Myeloid; Oligonucleotides, Antisense; Quinones; ras Proteins; Rifabutin; Wortmannin | 1999 |
Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Rats; Receptor, Insulin; Recombinant Fusion Proteins; Signal Transduction; Transfection; Wortmannin | 1999 |
Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases.
Topics: Androstadienes; Animals; Aorta; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Insulin-Like Growth Factor I; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rabbits; Stimulation, Chemical; Wortmannin | 1999 |
Serum induction of the collagen X promoter requires the Raf/MEK/ERK and p38 pathways.
Topics: Androstadienes; Blood Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chondrocytes; Collagen; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Isoquinolines; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Pyridines; Signal Transduction; Sulfonamides; Transcriptional Activation; Transfection; Wortmannin | 1999 |
MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Maleimides; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Opioid, mu; Recombinant Proteins; Thionucleotides; Transfection; Wortmannin | 1999 |
Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic acid synthesis by insulin-like growth factor-I.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Chromones; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Vitronectin; Swine; Wortmannin | 1999 |
Adaptive increase of amino acid transport system A requires ERK1/2 activation.
Topics: Amino Acids; Androstadienes; beta-Alanine; Biological Transport; Carrier Proteins; Cell Size; Culture Media; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Hypertonic Solutions; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Sirolimus; Wortmannin | 1999 |
Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways.
Topics: Androstadienes; Antibodies, Monoclonal; Benzoquinones; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, ras; GTP-Binding Proteins; Humans; Imidazoles; Integrins; Jurkat Cells; Lactams, Macrocyclic; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neoplasm Proteins; Peptide Fragments; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras); Pyridines; Quinones; Rifabutin; src-Family Kinases; T-Lymphocytes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin | 1999 |
Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications.
Topics: Amino Acids; Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen Synthase; Insulin; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Muscle Contraction; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 1999 |
Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adipocytes; Amino Acid Substitution; Androstadienes; Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Epididymis; Flavonoids; Genistein; Insulin; Kinetics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Recombinant Proteins; Signal Transduction; src Homology Domains; Threonine; Wortmannin | 1999 |
Mitogen-activated protein kinase mediates erythropoietin-induced phosphorylation of the TAL1/SCL transcription factor in murine proerythroblasts.
Topics: Androstadienes; Anemia; Animals; Basic Helix-Loop-Helix Transcription Factors; DNA-Binding Proteins; Enzyme Inhibitors; Erythroblasts; Flavonoids; Friend murine leukemia virus; Hematopoietic Stem Cells; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphopeptides; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins; Recombinant Proteins; Spleen; T-Cell Acute Lymphocytic Leukemia Protein 1; Transcription Factors; Wortmannin | 1999 |
Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons.
Topics: Androstadienes; Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Cytokines; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Flavonoids; In Situ Nick-End Labeling; Mice; Midkine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Wortmannin | 1999 |
Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.
Topics: Androstadienes; Angiotensinogen; Animals; Cell Line, Transformed; Enzyme Inhibitors; Flavonoids; Gene Expression; Glucose; Insulin; Kidney Tubules, Proximal; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 1999 |
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.
Topics: Actins; Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chemokine CXCL12; Chemokines, CXC; Chemotaxis, Leukocyte; Enzyme Activation; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Jurkat Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; T-Lymphocytes; Virulence Factors, Bordetella; Wortmannin | 1999 |
Involvement of PI 3-kinase and activated ERK in facilitating insulin-stimulated triacylglycerol synthesis in hepatocytes.
Topics: Acetyl-CoA Carboxylase; Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Glucose; Insulin; Liver; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sirolimus; Triglycerides; Wortmannin | 1999 |
The role of phosphatidylinositol 3-kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression.
Topics: Androstadienes; Animals; Benzoquinones; Bucladesine; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glucagon; Insulin; Lactams, Macrocyclic; Liver; Male; Phosphatidylinositol 3-Kinases; Quinones; Rats; RNA, Messenger; Signal Transduction; src-Family Kinases; Wortmannin | 1999 |
Involvement of a phosphatidylinositol 3-kinase-p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells.
Topics: Activating Transcription Factor 2; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP Response Element-Binding Protein; Dinitrophenols; Enzyme Activation; Flavonoids; Imidazoles; Interleukin-4; Mast Cells; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Serum Albumin; Transcription Factors; Wortmannin | 2000 |
Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2.
Topics: Androstadienes; Animals; Biological Transport; Carrier Proteins; Cell Line; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Glucose; Glucose Transporter Type 4; Humans; Leptin; Mice; Mitogen-Activated Protein Kinase 1; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, Cell Surface; Receptors, Leptin; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Wortmannin | 1999 |
Prevention of v-Ha-Ras-dependent apoptosis by PDGF coordinates in phosphorylation of ERK and Akt.
Topics: Androstadienes; Apoptosis; Cell Line; Cell Survival; Culture Media, Serum-Free; Dexamethasone; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Flavonoids; Genes, ras; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Transfection; Ultraviolet Rays; Wortmannin | 2000 |
Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2 expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell line HEC-1B.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents, Hormonal; Chorionic Gonadotropin; Cyclic AMP; Cyclooxygenase 2; Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Estradiol; Female; Flavonoids; Humans; Isoenzymes; Isoquinolines; Medroxyprogesterone Acetate; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Thionucleotides; Tumor Cells, Cultured; Wortmannin | 1999 |
Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Progesterone Reductase; Signal Transduction; STAT6 Transcription Factor; Steroid Isomerases; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Wortmannin | 2000 |
TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity.
Topics: Androstadienes; Animals; Axons; Chromones; Cloning, Molecular; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Humans; Kinetics; Morpholines; Motor Neurons; Nerve Growth Factors; Nerve Tissue Proteins; Neurturin; Nodal Protein; Organ Culture Techniques; Rats; Recombinant Proteins; Spinal Cord; Transforming Growth Factor beta; Wortmannin | 2000 |
Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells.
Topics: Androstadienes; Cell Division; Cell Movement; Cells, Cultured; Chemotactic Factors; Chromones; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; Liver; Mitogen-Activated Protein Kinases; Mitogens; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Wortmannin | 2000 |
Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
Topics: Adenocarcinoma; Androstadienes; Breast Neoplasms; Butadienes; Chromones; Culture Media, Serum-Free; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Depression, Chemical; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Flavonoids; Fulvestrant; Humans; Isoquinolines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Morpholines; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Sulfonamides; Wortmannin | 2000 |
Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase.
Topics: Androstadienes; Animals; Chromatography, Ion Exchange; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Kinetics; Male; Myocardium; Phosphofructokinase-2; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Wortmannin | 2000 |
Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line.
Topics: Androstadienes; Animals; Cell Differentiation; Dimethyl Sulfoxide; Down-Regulation; Enzyme Inhibitors; Erythropoietin; Flavonoids; Friend murine leukemia virus; Gene Transfer Techniques; Genes, Dominant; Globins; JNK Mitogen-Activated Protein Kinases; Leukemia, Erythroblastic, Acute; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Protein Serine-Threonine Kinases; ras Proteins; Repressor Proteins; Tumor Cells, Cultured; Wortmannin | 2000 |
Insulin-induced gene 33 mRNA expression in Chinese hamster ovary cells is insulin receptor dependent.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Blotting, Northern; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glucose; Humans; Immunoblotting; Insulin; Naphthalenes; Organophosphonates; Phosphorylation; Protein Binding; Protein Biosynthesis; Protein-Tyrosine Kinases; Proteins; Receptor, ErbB-2; Receptor, Insulin; Signal Transduction; Sirolimus; Time Factors; Transfection; Tumor Suppressor Proteins; Wortmannin | 2000 |
Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.
Topics: Androstadienes; Apoptosis; Carcinoma; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Antisense; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Recombinant Fusion Proteins; Staurosporine; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Tumor necrosis factor alpha inhibits insulin-induced mitogenic signaling in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 2000 |
Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways.
Topics: 3T3 Cells; Androstadienes; Animals; Cycloheximide; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Insulin; Insulin-Like Growth Factor I; Kinetics; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2000 |
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt.
Topics: Adenoviridae; Androstadienes; CCAAT-Enhancer-Binding Proteins; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Estrogen Antagonists; Flavonoids; Gene Expression Regulation; Genetic Vectors; Hepatocytes; Immunoblotting; Insulin; Liver; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Recombinant Fusion Proteins; Recombinant Proteins; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Tamoxifen; Time Factors; Transcription Factors; Transduction, Genetic; Wortmannin | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase.
Topics: Androstadienes; Animals; Bradykinin; Cattle; Endothelium, Vascular; Enzyme Activation; Flavonoids; Gene Expression Regulation, Enzymologic; Mitogen-Activated Protein Kinases; Naphthalenes; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Receptor, Bradykinin B2; Receptors, Bradykinin; Wortmannin | 2000 |
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
Topics: Adrenergic alpha-Agonists; Androstadienes; Cell Cycle; Chemotaxis; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras.
Topics: Androstadienes; Animals; Cell Differentiation; Cell Survival; Cell Transformation, Neoplastic; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Insulin Receptor Substrate Proteins; MAP Kinase Kinase Kinase 1; Mice; Mice, Nude; Morpholines; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Serine-Threonine Kinases; Rabbits; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways.
Topics: Androstadienes; Apoptosis; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoietin; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Stem Cell Factor; Wortmannin | 2000 |
Differential regulation of phospholipase C-beta isozymes in cardiomyocyte hypertrophy.
Topics: Androstadienes; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Growth Hormone; Insulin-Like Growth Factor I; Isoenzymes; Norepinephrine; Oligonucleotides, Antisense; Phospholipase C beta; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sirolimus; Type C Phospholipases; Wortmannin | 2000 |
Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Androstadienes; Animals; Cell Differentiation; Clone Cells; Dexamethasone; Flavonoids; Insulin; Insulin Antagonists; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Retinoblastoma Protein; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2000 |
Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin.
Topics: Androstadienes; Animals; Caffeine; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphorylation; Phosphoserine; Precipitin Tests; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Pyridines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Wortmannin | 2000 |
Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Mice; Mutagenesis; Myristic Acid; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transcription Factors; Transfection; Vanadates; Wortmannin | 2000 |
Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy.
Topics: Androstadienes; Animals; Antigens, CD; Cardiomegaly; Cell Size; Cells, Cultured; Cytokine Receptor gp130; Flavonoids; Genetic Markers; Growth Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Myocardium; Phenylalanine; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Signal Transduction; Trans-Activators; Tyrphostins; Wortmannin | 2000 |
Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression.
Topics: Androstadienes; Cell Division; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucose; Glucose Transporter Type 1; Humans; Insulin; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Somatostatin; Tumor Cells, Cultured; Wortmannin | 2000 |
Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hepatocytes; Humans; Insulin; Marine Toxins; Mitogen-Activated Protein Kinases; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Regulation of p38 mitogen-activated protein kinase during NK cell activation.
Topics: Androstadienes; Antibody-Dependent Cell Cytotoxicity; Cytotoxicity, Immunologic; Enzyme Inhibitors; Enzyme Precursors; Flavonoids; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lymphocyte Activation; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Receptors, IgG; src-Family Kinases; Syk Kinase; Wortmannin | 2000 |
Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromones; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Intestinal Mucosa; Mitogen-Activated Protein Kinases; Morpholines; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Receptor, IGF Type 1; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 2000 |
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Hypertonic Solutions; I-kappa B Kinase; Imidazoles; Inflammation; Insulin-Like Growth Factor I; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandins A; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Stress, Physiological; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation.
Topics: Androstadienes; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Human Growth Hormone; Humans; Insulin; Iodine Radioisotopes; Janus Kinase 2; Liver; Liver Neoplasms, Experimental; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Cell Surface; Receptors, Somatotropin; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Wortmannin | 2000 |
Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes.
Topics: Androstadienes; Antineoplastic Agents; Blood Vessels; Blotting, Western; Cell Division; Cell Movement; Cells, Cultured; Chemotaxis; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genistein; Humans; Ligands; Liver; Mitogen-Activated Protein Kinases; Pericytes; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptors, Chemokine; Receptors, CXCR3; Recombinant Proteins; Signal Transduction; src-Family Kinases; Time Factors; Wortmannin | 2001 |
Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Apoptosis; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sirolimus; Wortmannin | 2001 |
Rap1A protein interferes with various MAP kinase activating pathways in skeletal myogenic cells.
Topics: Androstadienes; Blood Proteins; Blotting, Western; Cell Division; Cell Line; Cyclic AMP; Down-Regulation; Enzyme Activation; Flavonoids; Guanosine Diphosphate; Guanosine Triphosphate; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; rap1 GTP-Binding Proteins; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
CNTFR alpha alone or in combination with CNTF promotes macrophage chemotaxis in vitro.
Topics: Androstadienes; Animals; Antigens, CD; Chemotactic Factors; Chemotaxis; Chromones; Ciliary Neurotrophic Factor; Cytokine Receptor gp130; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Growth Inhibitors; Humans; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Macrophages, Peritoneal; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Subunits; Receptor, Ciliary Neurotrophic Factor; Recombinant Proteins; Wortmannin | 2000 |
Comparison of macrophage responses to oxidized low-density lipoprotein and macrophage colony-stimulating factor (M-CSF or CSF-1).
Topics: Androstadienes; Animals; Bone Marrow Cells; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Lipoproteins, LDL; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Inbred CBA; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Wortmannin | 2001 |
Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.
Topics: Adenine; Androstadienes; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Hydrocortisone; Indomethacin; Naphthalenes; Nifedipine; Oligopeptides; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase C; Pyrazoles; Pyrrolidinones; Receptors, Endothelin; Signal Transduction; Type C Phospholipases; Tyrphostins; Wortmannin; Zona Fasciculata; Zona Reticularis | 2001 |
Involvement of both phosphatidylinositol 3-kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocytes; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyruvate Kinase; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 2001 |
Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Division; Cells, Cultured; Chromones; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinases; Morpholines; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Recombinant Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells.
Topics: 3T3 Cells; Androstadienes; Animals; Becaplermin; Blotting, Western; Cell Division; Cell Survival; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Ribosomal Protein S6 Kinases; Ribs; Signal Transduction; Sirolimus; Wortmannin | 2001 |
Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury.
Topics: Androstadienes; Animals; Base Sequence; Blotting, Western; Cells, Cultured; DNA Primers; DNA Replication; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelium, Vascular; Fibroblast Growth Factor 2; Flavonoids; Glucose; Humans; Imidazoles; Immediate-Early Proteins; Insulin; Oligonucleotides, Antisense; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Wortmannin | 2001 |
Insulin-like growth factor I inhibits cardiomyocyte apoptosis and the underlying signal transduction pathways.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; DNA Fragmentation; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genistein; Heart; Hypoxia; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron; Myocardium; Rats; Signal Transduction; Wortmannin | 2000 |
Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator.
Topics: Androstadienes; Antineoplastic Agents; Biomarkers; Cell Differentiation; Diterpenes; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Interferon-gamma; Leukemia, Myeloid; Lipopolysaccharide Receptors; Maleimides; Monocytes; Naphthalenes; Plant Growth Regulators; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells; Virulence Factors, Bordetella; Wortmannin | 2001 |
Opposite regulation of the HPV 20-URR and HPV 27-URR promoters by ultraviolet irradiation and cytokines.
Topics: Androstadienes; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Chloramphenicol O-Acetyltransferase; Colonic Neoplasms; Cytokines; DNA, Viral; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Green Fluorescent Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Luminescent Proteins; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Papillomaviridae; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Signal Transduction; Tumor Cells, Cultured; Ultraviolet Rays; Wortmannin | 2001 |
Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.
Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Subunits; Pyridines; Ribosomal Protein S6 Kinases; Sirolimus; Transfection; Ultraviolet Rays; Wortmannin | 2001 |
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
Topics: Androstadienes; Benzoquinones; Blotting, Western; Cell Division; Cells, Cultured; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Indoles; Lactams, Macrocyclic; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Isoforms; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rifabutin; Thrombin; Time Factors; Trachea; Transfection; Virulence Factors, Bordetella; Wortmannin | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Corpus Striatum; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Wortmannin | 2001 |
Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Colforsin; Flavonoids; Humans; In Vitro Techniques; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin | 2001 |
Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.
Topics: Androstadienes; Apoptosis; Chemotaxis, Leukocyte; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leukotriene B4; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Virulence Factors, Bordetella; Wortmannin | 2001 |
Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Blood Platelets; Chromones; Cytoplasmic Granules; Enzyme Inhibitors; Flavonoids; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Platelet Aggregation; Protein Serine-Threonine Kinases; Thrombin; Thrombopoietin; Wortmannin | 2001 |
Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways.
Topics: Androstadienes; Animals; Cell Adhesion Molecules; Cell Line; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Fucose; Gene Expression Regulation; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kinetics; Ligands; Lipoproteins, LDL; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polysaccharides; Pyridines; Receptors, Immunologic; Receptors, Scavenger; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoquinones; Cell Differentiation; Chromones; Cyclic AMP; Enzyme Inhibitors; Flavonoids; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Indoles; Isoproterenol; Isoquinolines; Lactams, Macrocyclic; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sirolimus; Sulfonamides; Tumor Cells, Cultured; Wortmannin | 2001 |
Grb-2-associated binder-1 is involved in insulin-induced egr-1 gene expression through its phosphatidylinositol 3'-kinase binding site.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Binding Sites; Butadienes; Cell Line; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression Regulation; Immediate-Early Proteins; Insulin; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Transcription Factors; Transfection; Wortmannin | 2001 |
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.
Topics: Adenosine; Androstadienes; Animals; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Receptor, Adenosine A3; Receptors, Purinergic P1; Recombinant Fusion Proteins; Wortmannin | 2001 |
Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Androstadienes; Animals; Cell Death; Culture Media, Serum-Free; Dentate Gyrus; Enzyme Inhibitors; Extracellular Space; Flavonoids; Fluorescent Dyes; Glutamic Acid; Hippocampus; MAP Kinase Signaling System; Microscopy, Confocal; Neuroprotective Agents; Organ Culture Techniques; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Propidium; Rats; Rats, Wistar; Receptors, Glutamate; Wortmannin | 2001 |
Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway.
Topics: Acetylcysteine; Androstadienes; Animals; Cyclic N-Oxides; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Indoles; Isoquinolines; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neurites; Neuroprotective Agents; Nitrogen Oxides; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Protein Kinase C; ras Proteins; Rats; Recombinant Proteins; Signal Transduction; Sulfonamides; Transfection; Wortmannin | 2001 |
Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.
Topics: Androstadienes; Animals; Apoptosis; Caspase 3; Caspases; Cattle; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Insulin-Like Growth Factor I; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Retina; Transfection; Wortmannin | 2001 |
HGF- and KGF-induced activation of PI-3K/p70 s6 kinase pathway in corneal epithelial cells: its relevance in wound healing.
Topics: Androstadienes; Animals; Cell Communication; Enzyme Inhibitors; Epithelium, Corneal; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Hepatocyte Growth Factor; MAP Kinase Signaling System; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rabbits; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin; Wound Healing | 2001 |
Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.
Topics: Adipocytes; Androstadienes; Animals; Dantrolene; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 2; Glucose; Glucose Transporter Type 4; Isoenzymes; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phospholipase D; Protein Kinase C; Protein Transport; Protein-Tyrosine Kinases; Rats; Wortmannin | 2001 |
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells.
Topics: Androstadienes; Butadienes; Chromones; Enzyme Inhibitors; Female; Fibronectins; Flavonoids; Humans; Indoles; Maleimides; MAP Kinase Kinase 1; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neoplasm Invasiveness; Nitriles; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured; Wortmannin | 2000 |
Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase.
Topics: Androstadienes; Animals; Cell Movement; Cells, Cultured; Clone Cells; Dinitrophenols; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Haptens; Imidazoles; Immunization; Immunoglobulin E; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-kit; Pyridines; Receptors, IgE; rho-Associated Kinases; Serum Albumin; Wortmannin | 2001 |
IL-6 upregulates its own receptor on some human myeloma cell lines.
Topics: Androstadienes; Antibodies, Monoclonal; Blotting, Northern; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Growth Inhibitors; Humans; Immunoblotting; Interleukin-6; Janus Kinase 2; Leukemia Inhibitory Factor; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Multiple Myeloma; Oncostatin M; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Interleukin-6; Signal Transduction; Tyrphostins; Up-Regulation; Wortmannin | 2001 |
Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.
Topics: Androstadienes; Animals; Cell Movement; Fibroblasts; Flavonoids; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Wortmannin | 2001 |
Evidence for two mechanisms of amino acid osmolyte release from hippocampal slices.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Androstadienes; Angiogenesis Inhibitors; Animals; Aspartic Acid; Cyclooxygenase Inhibitors; Cytochalasins; Enzyme Inhibitors; Flavonoids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Imidazoles; In Vitro Techniques; Mitogen-Activated Protein Kinases; Niflumic Acid; Nitrobenzoates; Osmolar Concentration; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyridines; Rats; Taurine; Tritium; Tyrphostins; Wortmannin | 2001 |
Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells.
Topics: Androstadienes; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Line; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Glial Cell Line-Derived Neurotrophic Factor; Humans; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; Nerve Growth Factors; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Wortmannin | 2001 |
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Topics: Androstadienes; Benzylamines; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Epithelial Cells; Flavonoids; Genistein; Humans; Indoles; Interleukin-8; Isoquinolines; Lung; Maleimides; Okadaic Acid; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Sulfonamides; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2001 |
Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter.
Topics: Androstadienes; Animals; Cell Nucleus; DNA; Enzyme Inhibitors; Flavonoids; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Nerve Growth Factor; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sirolimus; Sp1 Transcription Factor; Transfection; Up-Regulation; Wortmannin | 2001 |
Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry.
Topics: Androstadienes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apigenin; Blood Proteins; Butadienes; Cell Division; Chickens; Chromones; Enzyme Inhibitors; Flavonoids; Hair Cells, Auditory; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Regeneration; Ribosomal Protein S6 Kinases; S Phase; Sirolimus; Wortmannin | 2001 |
p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chemotactic Factors; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Morpholines; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Wortmannin | 2001 |
In vivo intracellular signaling as a marker of antiangiogenic activity.
Topics: Androstadienes; Angiogenesis Inhibitors; Biomarkers, Tumor; Blotting, Western; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Humans; Indoles; Liver Neoplasms; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Pathologic; Oxindoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Propionates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2001 |
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin | 2001 |
Phosphatidylinositol 3-kinase and ERK are required for NF-kappaB activation but not for phagocytosis.
Topics: Actin Cytoskeleton; Actins; Androstadienes; Cell Line; Chromones; Cytochalasin B; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Humans; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; NF-kappa B; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, IgG; Signal Transduction; Transcription, Genetic; Wortmannin | 2001 |
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin | 2001 |
Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Receptor, Endothelin A; Receptors, Endothelin; src Homology Domains; src-Family Kinases; Time Factors; Tyrosine; Wortmannin | 2001 |
Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line.
Topics: Androstadienes; Animals; Apoptosis; Bacterial Toxins; Butadienes; Cell Line; Chromones; DNA; Enterotoxins; Enzyme Inhibitors; Flavonoids; Hepatocytes; Humans; Lysophospholipids; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.
Topics: Adult; Androstadienes; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Growth Substances; Hepatocyte Growth Factor; Humans; Imidazoles; Insecta; Macrophages; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Proto-Oncogene Proteins; Pyridines; Receptors, Drug; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Differential role of kinases in brain stem of hypertensive and normotensive rats.
Topics: Androstadienes; Angiotensin II; Animals; Apnea; Blood Pressure; Brain Stem; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Hypertension; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstrictor Agents; Wortmannin | 2001 |
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.
Topics: Androstadienes; Carrier Proteins; Eukaryotic Initiation Factor-4E; Flavonoids; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Sulfonamides; Ultraviolet Rays; Wortmannin | 2002 |
Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.
Topics: Androstadienes; Anisomycin; Blotting, Western; Colforsin; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Flavonoids; Glioma; Humans; Imidazoles; Immediate-Early Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Suramin; Transcription Factors; Wortmannin | 2002 |
Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Carrier Proteins; Cell Cycle Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; Interleukin-6; Kinetics; MAP Kinase Signaling System; Multiple Myeloma; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Repressor Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tumor Cells, Cultured; Wortmannin | 2002 |
Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Cells, Cultured; Dantrolene; Enzyme Activation; Enzyme Inhibitors; Epididymis; Flavonoids; Focal Adhesion Kinase 2; Glucose Transporter Type 4; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phospholipase D; Protein Kinase C; Protein Transport; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Sorbitol; Transfection; Wortmannin | 2002 |
Signaling pathways involved in the physiological response of mussel hemocytes to bacterial challenge: the role of stress-activated p38 MAP kinases.
Topics: Androstadienes; Animals; Bivalvia; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavonoids; Hemocytes; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Wortmannin | 2002 |
Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Flavonoids; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Insulin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2002 |
Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages.
Topics: Androstadienes; Animals; Benzoquinones; Carrier Proteins; Cell Movement; Chondroitin Sulfates; Cytokines; Dermatan Sulfate; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Lactams, Macrocyclic; Macrophages; Mice; Midkine; Protein Tyrosine Phosphatases; Pyrazoles; Pyrimidines; Pyrrolidinones; Quinones; Rats; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Signal Transduction; Wortmannin | 2001 |
Overexpression of PEMT2 downregulates the PI3K/Akt signaling pathway in rat hepatoma cells.
Topics: Androstadienes; Animals; Apoptosis; Blotting, Western; Down-Regulation; Enzyme Inhibitors; Flavonoids; Liver Neoplasms, Experimental; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Transfection; Tumor Cells, Cultured; Wortmannin | 2002 |
Molecular mechanism(s) of insulin action on the expression of the angiotensinogen gene in kidney proximal tubular cells.
Topics: Androstadienes; Angiotensinogen; Animals; Artificial Gene Fusion; Cell Line; Diglycerides; Enzyme Inhibitors; Flavonoids; Gene Expression; Glucose; Human Growth Hormone; Humans; Insulin; Kidney Tubules, Proximal; Naphthalenes; Opossums; Peptide Fragments; Promoter Regions, Genetic; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
Topics: Amino Acid Sequence; Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Conserved Sequence; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Humans; Phosphorylation; ran GTP-Binding Protein; Sirolimus; Transcription Factors; Wortmannin | 2002 |
Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats.
Topics: Adipocytes; Aging; Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Vanadates; Wortmannin | 2002 |
IGF-1 regulates migration and angiogenesis of human endothelial cells.
Topics: Androstadienes; Cell Movement; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glucose; Humans; Insulin-Like Growth Factor I; Morpholines; Neovascularization, Physiologic; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Ischemic Preconditioning; Male; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Wortmannin | 2002 |
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin | 2002 |
Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Animals; Cell Culture Techniques; Chick Embryo; Chromones; Electrophysiology; Enzyme Inhibitors; Flavonoids; Immunoblotting; Immunohistochemistry; Large-Conductance Calcium-Activated Potassium Channels; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channels, Calcium-Activated; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transforming Growth Factor beta; Wortmannin | 2002 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.
Topics: Androstadienes; Antineoplastic Agents; Benzamides; Caspase 3; Caspases; Chromones; Drug Synergism; Enzyme Inhibitors; Flavonoids; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Pyrimidines; Reference Values; Tumor Cells, Cultured; Wortmannin | 2002 |
Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Angiotensin II; Animals; Anti-Bacterial Agents; Cell Division; Cells, Cultured; Endothelium; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Swine; Wortmannin | 2002 |
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.
Topics: Androstadienes; Carcinoma, Squamous Cell; Caveolae; Caveolin 1; Caveolins; Cell Line; Chromones; Colchicine; Cyclodextrins; Cytochalasin D; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Kinetics; Morpholines; Nucleic Acid Synthesis Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; src-Family Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2002 |
Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.
Topics: Adenosine; Androstadienes; Arginine; Biological Transport; Butadienes; Calcium; Cells, Cultured; Chromones; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Fetus; Flavonoids; Gene Expression; Genistein; Humans; Hydrogen-Ion Concentration; MAP Kinase Signaling System; Membrane Potentials; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitriles; Phenethylamines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium; Protein Isoforms; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin | 2002 |
Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcysteine; Androstadienes; Antibiotics, Antineoplastic; Antioxidants; Bridged-Ring Compounds; Cell Death; Daunorubicin; Diglycerides; Enzyme Activation; Flavonoids; Humans; Leukemia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Norbornanes; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-raf; Reactive Oxygen Species; Thiocarbamates; Thiones; Transfection; Tumor Cells, Cultured; Wortmannin | 2003 |
Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.
Topics: Androstadienes; Cell Line; Cell Movement; Chemotaxis; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Leptin; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins; Wortmannin | 2002 |
Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes.
Topics: Androstadienes; Cell Survival; Chromones; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; In Vitro Techniques; Macrophage Colony-Stimulating Factor; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Reactive Oxygen Species; Wortmannin | 2002 |
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Topics: Androstadienes; Animals; Apoptosis; Carcinoma; Chromones; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Laminin; Male; Mice; Mice, Nude; Morpholines; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured; Wortmannin | 2002 |
Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation.
Topics: Adipocytes; Androstadienes; Cell Differentiation; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leptin; Lipid Metabolism; Lipids; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rosiglitazone; Signal Transduction; Sirolimus; Stem Cells; Thiazoles; Thiazolidinediones; Tumor Necrosis Factor-alpha; Wortmannin | 2003 |
Physiological concentration of atrial natriuretic peptide induces endothelial regeneration in vitro.
Topics: Actins; Androstadienes; Atrial Natriuretic Factor; Cell Count; Cell Division; Cell Survival; Cells, Cultured; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Regeneration; Thionucleotides; Umbilical Veins; Wortmannin; Wound Healing | 2003 |
Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Topics: Androstadienes; Cell Division; Cell Survival; Chemokine CCL3; Chemokine CCL4; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Macrophage Inflammatory Proteins; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multiple Myeloma; Neoplasm Proteins; Osteolysis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Chemokine; Signal Transduction; Tumor Cells, Cultured; Wortmannin | 2003 |
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression.
Topics: Androstadienes; Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle Proteins; Cell Division; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cyclin A; Cyclin D1; Cyclin E; DNA-Binding Proteins; Dose-Response Relationship, Drug; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; E2F3 Transcription Factor; Electrophoresis, Polyacrylamide Gel; Endothelial Growth Factors; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Proliferating Cell Nuclear Antigen; Pyridines; Signal Transduction; Time Factors; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2003 |
Steroidogenic responses of pig corpora lutea to insulin-like growth factor I (IGF-I) throughout the oestrous cycle.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Corpus Luteum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrus; Female; Flavonoids; Follicular Phase; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Progesterone; Receptor, IGF Type 1; Signal Transduction; Sus scrofa; Wortmannin | 2003 |
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Topics: Amino Acid Substitution; Androstadienes; Animals; Carcinoma, Lewis Lung; Chromones; Collagen; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Insulin-Like Growth Factor I; Laminin; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Morpholines; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Point Mutation; Promoter Regions, Genetic; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptor, IGF Type 1; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2003 |
Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway.
Topics: Androstadienes; Annexin A5; Apoptosis; Cell Survival; Dose-Response Relationship, Immunologic; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Fluorescent Dyes; Humans; Leptin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Monocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Propidium; Wortmannin | 2002 |
Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.
Topics: Androstadienes; Cell Division; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Insulin-Like Growth Factor Binding Protein 2; Male; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Prostate; Prostatic Neoplasms; Recombinant Proteins; Telomerase; Tumor Cells, Cultured; Wortmannin | 2003 |
Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway.
Topics: Androstadienes; Animals; Antioxidants; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Platelet-Derived Growth Factor; Polyphenols; Protein Processing, Post-Translational; Pyridines; Rats; Reactive Oxygen Species; RNA, Messenger; Thrombin; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Wine; Wortmannin | 2003 |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin | 2003 |
Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.
Topics: Agar; Androstadienes; Animals; Blotting, Western; Cell Cycle; Cell Division; Cell Separation; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Flow Cytometry; G1 Phase; Glioblastoma; Humans; MAP Kinase Signaling System; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; PTEN Phosphohydrolase; S Phase; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2003 |
The same cellular signaling pathways mediate survival in sensory neurons that switch their trophic requirements during development.
Topics: Androstadienes; Animals; Arabidopsis Proteins; Cell Division; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Ganglia, Spinal; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurons, Afferent; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channels; Rats; Signal Transduction; Wortmannin | 2003 |
Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis.
Topics: Androstadienes; Animals; Biological Assay; Cell Division; Cells, Cultured; Chromones; Collagen; Drug Combinations; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Laminin; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Wortmannin | 2003 |
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway.
Topics: Active Transport, Cell Nucleus; Androstadienes; Animals; Blotting, Western; Cell Line; Cell Nucleus; Cobalt; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, Reporter; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Ligases; Lymphokines; MAP Kinase Signaling System; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Viral Regulatory and Accessory Proteins; Von Hippel-Lindau Tumor Suppressor Protein; Wortmannin | 2003 |
IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.
Topics: Androstadienes; Anilides; Animals; Annexin A5; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cell Survival; Chromones; Culture Media, Serum-Free; Flavonoids; Flow Cytometry; Humans; Imidazoline Receptors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Morpholines; Oligopeptides; PC12 Cells; Proteins; Rats; Staurosporine; Thapsigargin; Transfection; Wortmannin | 2003 |
Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity.
Topics: Androstadienes; Blotting, Western; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neuroblastoma; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; rac GTP-Binding Proteins; Somatostatin; Wortmannin | 2003 |
Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist.
Topics: Androstadienes; Animals; Animals, Newborn; Carbazoles; Chickens; Estrenes; Flavonoids; Indoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Neutrophils; Nitriles; Pyrrolidinones; Receptors, Cell Surface; Respiratory Burst; Signal Transduction; Sulfones; Teichoic Acids; Toll-Like Receptor 2; Toll-Like Receptors; Wortmannin | 2003 |
IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.
Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin | 2003 |
Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin | 2003 |
Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase.
Topics: Androstadienes; Apoptosis; Calcium Pyrophosphate; Caspase 3; Caspases; Cell Degranulation; Crystallization; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Muramidase; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Superoxides; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.
Topics: Androstadienes; Blotting, Western; Cell Line; Chlorides; Chlorine; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; GTP-Binding Protein alpha Subunits, Gs; Humans; Ions; Isoquinolines; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Quinazolines; Sulfonamides; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium.
Topics: Androstadienes; Animals; Benzoquinones; Cell Hypoxia; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinones; Swine; Time Factors; Up-Regulation; Wortmannin | 2004 |
Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration.
Topics: Androstadienes; Cerebrovascular Circulation; Chemotaxis; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A; Wortmannin | 2004 |
Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures.
Topics: Androstadienes; Animals; Animals, Newborn; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flavonoids; Gene Expression; Immunohistochemistry; Microtubule-Associated Proteins; Neurites; Neurons; Oligonucleotides, Antisense; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tubulin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Wortmannin | 2004 |
Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.
Topics: Androstadienes; Animals; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Transport Complex IV; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Profiling; Hepatocytes; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Mitochondrial Proteins; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nuclear Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; RNA, Mitochondrial; Transcription Factors; Tyrphostins; Up-Regulation; Wortmannin | 2004 |
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
Topics: Androstadienes; Animals; Blotting, Western; Carcinoma, Lewis Lung; Cell Line, Tumor; Chloramphenicol O-Acetyltransferase; Chromones; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Gene Expression Regulation, Enzymologic; Genes, Dominant; Genes, Reporter; Insulin-Like Growth Factor I; Matrix Metalloproteinase 2; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Plasmids; Proto-Oncogene Proteins c-raf; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sirolimus; Time Factors; Tumor Suppressor Proteins; Wortmannin | 2004 |
NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.
Topics: Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Androstadienes; Animals; Bradykinin; Caffeine; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Infarction; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; Receptors, Adenosine A2; Reperfusion; Signal Transduction; Vasodilator Agents; Wortmannin | 2004 |
Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.
Topics: Androstadienes; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glycogen Synthase; In Vitro Techniques; Indoles; Insulin; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Okadaic Acid; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.
Topics: Androstadienes; Angiotensin II; Animals; Aorta; Blotting, Western; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Mitogen-Activated Protein Kinases; Mitogens; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Rats; Retinoblastoma Protein; Serine; Serotonin; Time Factors; Wortmannin | 2004 |
Both mitogen activated protein kinase and the mammalian target of rapamycin modulate the development of functional renal proximal tubules in matrigel.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Biological Transport; Cell Polarity; Cells, Cultured; Collagen; Drug Combinations; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Kidney Tubules, Proximal; Laminin; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morphogenesis; Organic Anion Transport Protein 1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Protein Transport; Proteoglycans; Rabbits; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; TOR Serine-Threonine Kinases; Wheat Germ Agglutinins; Wortmannin | 2004 |
Role of ERK and Rho kinase pathways in central pressor action of urotensin II.
Topics: Amides; Androstadienes; Animals; Blood Pressure; Consciousness; Drug Synergism; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Urotensins; Wortmannin | 2004 |
Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Androstadienes; Animals; Bucladesine; Choline; Colforsin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Isoproterenol; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Pyrimidines; Quinazolines; Rats; Receptors, Adrenergic, beta; Saliva; src-Family Kinases; Sublingual Gland; Transcriptional Activation; Wortmannin | 2004 |
Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils.
Topics: Androstadienes; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspase 3; Caspases; CD11b Antigen; CD18 Antigens; Cell Adhesion; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Granulocytes; Humans; Inflammation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Activating Factor; Signal Transduction; Time Factors; Up-Regulation; Wortmannin | 2004 |
Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Cell Line; Chromones; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Insulin; Insulin Resistance; MAP Kinase Signaling System; Mice; Morpholines; Muscle, Skeletal; Muscles; Mutation; Phosphatidylinositol 3-Kinases; RNA; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Time Factors; Transcription Factors; Wortmannin | 2004 |
Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Topics: Androstadienes; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Tenascin; Wortmannin | 2004 |
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2004 |
The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.
Topics: Androstadienes; Animals; Animals, Newborn; Apoptosis; Brain-Derived Neurotrophic Factor; Caspase 3; Caspases; Cell Count; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flavonoids; Indoles; Mitogen-Activated Protein Kinases; Neurons; Peptide Fragments; Phosphatidylinositol 3-Kinases; Potassium; Precipitin Tests; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetanus Toxin; Tetrazolium Salts; Thiazoles; Time Factors; Wortmannin | 2004 |
Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.
Topics: Androstadienes; Animals; Apoptosis; Bone Marrow Transplantation; Cells, Cultured; Chemotaxis; Corneal Neovascularization; Flavonoids; Flow Cytometry; Hematopoietic Stem Cells; Humans; Lac Operon; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Inbred Strains; Mice, Transgenic; Neuropeptides; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radiation Chimera; Rats; Receptor, TIE-2; Secretogranin II; Signal Transduction; Vascular Endothelial Growth Factor A; Wortmannin | 2004 |
Regulation of Gene33 expression by insulin requires MEK-ERK activation.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Immune Sera; Insulin; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Signal Transduction; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2004 |
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
Topics: Androstadienes; Animals; Anthracenes; Cell Line; Cell Movement; Cell Survival; Chemokine CCL4; Chemotaxis; Chromones; Complement C5a; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophage Inflammatory Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin | 2004 |
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.
Topics: Aldosterone; Androstadienes; Animals; Blotting, Western; Calcium; Chromones; Enzyme Inhibitors; Eplerenone; Flavonoids; Hydrogen-Ion Concentration; Indoles; Male; Maleimides; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Morpholines; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Time Factors; Vasoconstriction; Wortmannin | 2005 |
Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways.
Topics: Adenylyl Cyclases; Alkaloids; Androstadienes; Animals; Blotting, Western; Cell Differentiation; Cell Membrane; CREB-Binding Protein; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinases; Molecular Structure; Nerve Growth Factor; Neurites; Nuclear Proteins; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridones; Rats; Signal Transduction; Subcellular Fractions; Trans-Activators; Wortmannin | 2004 |
Low proliferation and high apoptosis of osteoblastic cells on hydrophobic surface are associated with defective Ras signaling.
Topics: Androstadienes; Apoptosis; Cell Adhesion; Cell Proliferation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 1; Flavonoids; Focal Adhesions; Genes, ras; Humans; Hydrophobic and Hydrophilic Interactions; Osteoblasts; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Stress Fibers; Wortmannin | 2005 |
Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Animals; Antibiotics, Antineoplastic; Aorta; Carrier Proteins; Cattle; Cell Division; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2005 |
Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways.
Topics: Amyloid beta-Peptides; Androstadienes; Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Chemokine CXCL2; Chemokines; Enzyme Inhibitors; Flavonoids; Hippocampus; MAP Kinase Signaling System; Mice; Neurons; Peptide Fragments; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin | 2005 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Chemokines; Chromones; Cytokines; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-17; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Morpholines; NF-kappa B; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Wortmannin | 2005 |
Insulin enhanced thrombin-activable fibrinolysis inhibitor expression through PI3 kinase/Akt pathway.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Androstadienes; Animals; Carboxypeptidase B2; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Insulin; Insulin Resistance; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tamoxifen; Transcription, Genetic; Wortmannin | 2005 |
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin | 2005 |
PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung.
Topics: Androstadienes; Animals; Apoptosis; Cell Survival; Chromones; Extracellular Signal-Regulated MAP Kinases; Fetal Development; Fibroblast Growth Factor 1; Flavonoids; Gene Expression Regulation, Developmental; In Situ Nick-End Labeling; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Wortmannin | 2005 |
Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin.
Topics: Androstadienes; Animals; Blotting, Western; Cell Movement; Cells, Cultured; Chromones; Flavonoids; Lysophospholipids; Morpholines; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Wortmannin | 2005 |
Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.
Topics: Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Separation; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Down-Regulation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; MAP Kinase Kinase Kinases; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Oncogene Protein p21(ras); Phosphorylation; Proto-Oncogene Proteins c-fos; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Up-Regulation; Wortmannin | 2005 |
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
Topics: Amphiregulin; Androstadienes; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Line, Tumor; Culture Media, Serum-Free; EGF Family of Proteins; Enzyme Inhibitors; Flavonoids; Glycoproteins; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Models, Biological; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Wortmannin | 2005 |
Multiple pathways of apolipoprotein E signaling in primary neurons.
Topics: Analysis of Variance; Androstadienes; Animals; Apolipoproteins E; Blotting, Western; Calcium Channel Blockers; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Models, Neurological; Nerve Tissue Proteins; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Signal Transduction; src-Family Kinases; Time Factors; Wortmannin | 2005 |
Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstadienes; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Cell Differentiation; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HL-60 Cells; Humans; Indoles; Lactones; Maleimides; Models, Biological; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Wortmannin | 2005 |
Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation.
Topics: Adenoviridae; Androstadienes; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Caspase 3; Caspases; Cell Survival; Culture Media, Serum-Free; DNA; DNA Fragmentation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Green Fluorescent Proteins; Histones; Hypoxia; Immunoprecipitation; Interleukin-1 Receptor-Associated Kinases; Ischemia; Lipopolysaccharides; Membrane Glycoproteins; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Protein Kinases; Rats; Receptors, Cell Surface; Recombinant Proteins; Signal Transduction; Time Factors; Toll-Like Receptor 4; Toll-Like Receptors; Transgenes; Wortmannin | 2005 |
Morphogenetic plasticity of adult human pancreatic islets of Langerhans.
Topics: Adult; Androstadienes; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Islets of Langerhans; Keratins; Lectins, C-Type; Morphogenesis; Pancreatic Ducts; Pancreatitis-Associated Proteins; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Stem Cells; Wortmannin | 2005 |
Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide.
Topics: Actins; Alanine; Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Cell Movement; Chemotaxis; Chromones; Cytoskeleton; Dose-Response Relationship, Drug; Flavonoids; Humans; Immunoprecipitation; Integrin alphaV; Integrin alphaVbeta3; Integrin beta4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Peptides; Phosphorylation; Protein Binding; Protein Kinase C; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Signal Transduction; Temperature; Time Factors; Vitronectin; Wortmannin | 2005 |
Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.
Topics: Aging; Androstadienes; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Male; Mice; Mice, Inbred C57BL; Pancreas, Exocrine; Pancreatectomy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Regeneration; RNA, Small Interfering; Wortmannin | 2005 |
Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Blotting, Northern; Catalase; Cell Hypoxia; Cell Line; Flavonoids; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Immunoblotting; Microscopy, Fluorescence; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyridines; Pyrimidines; Rabbits; RNA, Messenger; Rotenone; Wortmannin | 2005 |
Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.
Topics: Androstadienes; Anthocyanins; Anthracenes; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Cell Survival; Cytochromes c; DNA, Mitochondrial; Dose-Response Relationship, Drug; Fas Ligand Protein; Flavonoids; Flowers; Hibiscus; HL-60 Cells; Humans; Imidazoles; Membrane Glycoproteins; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Proto-Oncogene Proteins c-jun; Pyridines; RNA, Messenger; Time Factors; Wortmannin | 2005 |
Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas.
Topics: Aged; Androstadienes; Apoptosis; Cell Proliferation; Cell Survival; Enzyme Activation; Female; Flavonoids; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Ki-67 Antigen; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; raf Kinases; ras Proteins; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Wortmannin | 2005 |
PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells.
Topics: Androstadienes; Animals; Becaplermin; Cells, Cultured; Chlorides; Chromones; Cyclosporine; Flavonoids; K Cl- Cotransporters; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Platelet-Derived Growth Factor; Potassium; Protein Phosphatase 1; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Symporters; Vanadates; Wortmannin | 2005 |
The anti-apoptotic effect of leukotriene B4 in neutrophils: a role for phosphatidylinositol 3-kinase, extracellular signal-regulated kinase and Mcl-1.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Kinetics; Leukotriene B4; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Reference Values; RNA, Messenger; Signal Transduction; Time Factors; Wortmannin | 2006 |
Adenosine triggers preconditioning through MEK/ERK1/2 signalling pathway during hypoxia/reoxygenation in neonatal rat cardiomyocytes.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Androstadienes; Animals; Animals, Newborn; Blotting, Western; Caspase 3; Caspase Inhibitors; Cell Hypoxia; Cell Survival; Cells, Cultured; Flavonoids; Ischemic Preconditioning; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 3; Models, Biological; Myocytes, Cardiac; Phenethylamines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Signal Transduction; Wortmannin | 2005 |
Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.
Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, High Pressure Liquid; Diterpenes; Diterpenes, Kaurane; Enzyme Activation; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Molecular Structure; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrrolidinones; Staurosporine; Time Factors; Type C Phospholipases; U937 Cells; Ultraviolet Rays; Wortmannin | 2005 |
HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.
Topics: Androstadienes; Butadienes; Cells, Cultured; Chromones; Flavonoids; HIV Envelope Protein gp120; Humans; Imidazoles; Macrophages; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptors, CCR5; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin | 2005 |
Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.
Topics: Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Caspase 8; Caspases; Cell Cycle; Cell Line, Tumor; Chromones; Colonic Neoplasms; Ecdysterone; Enzyme Activation; Fas Ligand Protein; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Membrane Glycoproteins; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Wortmannin | 2006 |
LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways.
Topics: Androstadienes; Arachidonate 5-Lipoxygenase; Benzoates; Butadienes; Cell Division; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flavonoids; Humans; Leukotriene B4; Mitogen-Activated Protein Kinases; Nitriles; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Signal Transduction; Wortmannin | 2005 |
Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
Topics: Alkaloids; Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Immunohistochemistry; Indole Alkaloids; Nerve Growth Factor; Neuroblastoma; Neuroprotective Agents; Oxidants; Oxidative Stress; Protein Kinase Inhibitors; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Wortmannin | 2005 |
Role of leptin in modulation of Porphyromonas gingivalis lipopolysaccharide-induced up-regulation of endothelin-1 in salivary gland acinar cells.
Topics: Analysis of Variance; Androstadienes; Animals; Dose-Response Relationship, Drug; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Leptin; Lipopolysaccharides; Mucins; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Rats; Signal Transduction; Sublingual Gland; Wortmannin | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.
Topics: Androstadienes; Animals; bcl-X Protein; Brain; Brain Ischemia; Enzyme Activation; Enzyme Inhibitors; Erythropoietin; Flavonoids; Humans; Hypoxia; Immunohistochemistry; Ischemia; Janus Kinase 2; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Erythropoietin; Signal Transduction; Time Factors; Wortmannin | 2005 |
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.
Topics: Androstadienes; Cell Proliferation; Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Splicing; Proto-Oncogene Proteins c-fos; Receptors, Estrogen; Receptors, G-Protein-Coupled; Selective Estrogen Receptor Modulators; Tamoxifen; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation; Wortmannin | 2006 |
Mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K) pathways differently regulate retinal pigment epithelial cell-mediated collagen gel contraction.
Topics: Androstadienes; Cell Line; Collagen; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Flow Cytometry; Gels; Humans; Integrin alpha1; Integrin alpha2; Integrin beta1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pigment Epithelium of Eye; Platelet-Derived Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stimulation, Chemical; Vitreoretinopathy, Proliferative; Wortmannin | 2006 |
Differential regulation of interleukin-12 and tumour necrosis factor-alpha by phosphatidylinositol 3-kinase and ERK 1/2 pathways during Mycobacterium tuberculosis infection.
Topics: Analysis of Variance; Androstadienes; Antigens, Bacterial; Butadienes; Cells, Cultured; Chromones; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Interleukin-12; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mycobacterium tuberculosis; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Tuberculosis; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells.
Topics: Androstadienes; Antibodies, Monoclonal; Autoantibodies; Cell Adhesion; Cell Shape; Cell Surface Extensions; Cytochalasin D; Cytoskeleton; Fibronectins; Flavonoids; Galectins; Humans; Integrin beta1; Jurkat Cells; Leukemia, T-Cell; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Kinase Inhibitors; rac1 GTP-Binding Protein; Thiogalactosides; Transfection; Wortmannin | 2006 |
Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways.
Topics: Acidosis; Androstadienes; Animals; Antigen Presentation; Calcium Signaling; Cell Shape; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Extracellular Fluid; Female; Flavonoids; Histocompatibility Antigens Class I; Humans; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neutrophil Activation; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Wortmannin | 2006 |
Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells.
Topics: Androstadienes; Angiopoietin-1; Angiopoietin-2; Animals; Cattle; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors; Flavonoids; Lung; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Transfection; Vascular Endothelial Growth Factor A; Wortmannin | 2006 |
Signaling transduction pathways involved in basophil adhesion and histamine release.
Topics: Androstadienes; Antibodies, Anti-Idiotypic; Basophils; CD18 Antigens; Cell Adhesion; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Histamine Release; Humans; Integrin beta1; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin | 2006 |
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Topics: Androstadienes; Animals; Cells, Cultured; Coronary Vessels; Flavonoids; Humans; Insulin; Insulin Resistance; Male; Mice; Myocardial Ischemia; Myocytes, Cardiac; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; Receptor, Insulin; Signal Transduction; Vascular Endothelial Growth Factor A; Wortmannin | 2006 |
Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways.
Topics: Androstadienes; Animals; Carrier Proteins; Cell Proliferation; Cell Survival; Cells, Cultured; Female; Flavonoids; Hydrogen Peroxide; Hypoxanthine; Insulin; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Theca Cells; TOR Serine-Threonine Kinases; Wortmannin | 2006 |
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Animals, Newborn; Cell Line; Cell Proliferation; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Enzyme Activation; Flavonoids; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Human Growth Hormone; Imidazoles; Insulin-Secreting Cells; Isoquinolines; Liraglutide; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Signal Transduction; Stimulation, Chemical; Sulfonamides; Transcription, Genetic; Transduction, Genetic; Wortmannin | 2006 |
Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells.
Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Etoposide; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Stomach Neoplasms; Tumor Suppressor Protein p53; Wortmannin | 2006 |
Contribution of Src-FAK signaling to the induction of connective tissue growth factor in renal fibroblasts.
Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Line, Transformed; Chromones; Colchicine; Collagen Type I; Connective Tissue Growth Factor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Extracellular Matrix; Fibroblasts; Flavonoids; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Humans; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Microscopy, Fluorescence; Models, Biological; Morpholines; Paclitaxel; Phalloidine; Rhodamines; Signal Transduction; src-Family Kinases; Transforming Growth Factor beta; Wortmannin | 2006 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis.
Topics: Androstadienes; Animals; Arachidonic Acids; Endothelin-1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastric Mucosa; Ginkgolides; Lactones; Lipopolysaccharides; Models, Biological; Mucins; Organophosphonates; Phosphatidylcholines; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Wortmannin | 2006 |
Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin.
Topics: Androstadienes; Butadienes; Chromones; Flavonoids; HeLa Cells; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Interleukin-8; Morpholines; NF-kappa B; Nitriles; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Protein Kinase C; Repressor Proteins; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways.
Topics: Amino Acid Sequence; Androstadienes; Angiotensin II; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Cell Line; Cell Proliferation; Endothelin-1; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Smooth, Vascular; Peptide Fragments; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Receptors, Atrial Natriuretic Factor; Signal Transduction; Vasoconstrictor Agents; Wortmannin | 2006 |
Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Cytokine Receptor gp130; Flavonoids; Gene Expression Regulation; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress.
Topics: Adenine Nucleotides; Adenosine; Androstadienes; Animals; Cells, Cultured; Cerebral Cortex; Chromones; Flavonoids; Glucose; Insulin; Lactic Acid; Morpholines; Neurons; Oxidative Stress; Phosphocreatine; Pyruvic Acid; Rats; Rats, Wistar; Thioinosine; Wortmannin | 2006 |
Intracellular peptides of natriuretic peptide receptor-C inhibit vascular hypertrophy via Gqalpha/MAP kinase signaling pathways.
Topics: Androstadienes; Angiotensin II; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blotting, Western; Cell Line; Cell Proliferation; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Flavonoids; GTP-Binding Protein alpha Subunits, Gq-G11; Leucine; MAP Kinase Signaling System; Myocytes, Smooth Muscle; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Stimulation, Chemical; Wortmannin | 2006 |
Calcineurin and Erk1/2-signaling pathways are involved in the antiapoptotic effect of cyclosporin A on astrocytes exposed to simulated ischemia in vitro.
Topics: Androstadienes; Animals; Animals, Newborn; Apoptosis; Astrocytes; bcl-X Protein; Blotting, Western; Calcineurin; Calcineurin Inhibitors; Caspase 3; Caspase Inhibitors; Cell Hypoxia; Cyclosporine; Dose-Response Relationship, Drug; Flavonoids; Immunoblotting; Immunosuppressive Agents; Mitogen-Activated Protein Kinase 3; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Signal Transduction; Transcription Factor RelA; Wortmannin | 2006 |
Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.
Topics: Androstadienes; Animals; Apoptosis; Cell Survival; Cells, Cultured; DNA; Flavonoids; Immunohistochemistry; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Leydig Cells; Male; Phosphorylation; Podophyllotoxin; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Testis; Wortmannin | 2007 |
Signaling pathway of insulin-like growth factor-II as a target of molecular therapy for hepatoblastoma.
Topics: Androstadienes; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Wortmannin | 2006 |
Reperfusion kinase phosphorylation is essential but not sufficient in the mediation of pharmacological preconditioning: Characterisation in the bi-phasic profile of early and late protection.
Topics: Androstadienes; Angiotensin II; Animals; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oncogene Protein v-akt; Perfusion; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Time Factors; Wortmannin | 2007 |
Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells.
Topics: Androstadienes; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Chloride Channels; Chromones; CLC-2 Chloride Channels; Female; Flavonoids; Insulin-Like Growth Factor I; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Swine; Wortmannin | 2007 |
Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor.
Topics: Amino Acid Sequence; Androgen Receptor Antagonists; Androstadienes; Aorta; Cells, Cultured; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ginsenosides; Humans; Imidazolidines; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Signal Transduction; Wortmannin | 2007 |
Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Dactinomycin; Enzyme Activation; Fibroblast Growth Factor 2; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A; Wortmannin | 2007 |
Insulin augments matrix metalloproteinase-9 expression in monocytes.
Topics: Androstadienes; Antibodies, Blocking; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Monocytes; Nitriles; Phospholipases A; Receptor, Insulin; Stimulation, Chemical; Time Factors; Wortmannin | 2007 |
Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells.
Topics: Androstadienes; Angiotensin II; Animals; Enzyme Activation; Flavonoids; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Muscle, Smooth, Vascular; Myogenic Regulatory Factors; Phosphorylation; Rats; Wortmannin | 2007 |
PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors.
Topics: Androstadienes; Cell Movement; Cells, Cultured; Chemotaxis; Endometrium; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Flavonoids; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Stromal Cells; Wortmannin | 2007 |
Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells.
Topics: Androstadienes; Animals; Cell Movement; Cell Proliferation; Chemokine CXCL12; Chemokines, CXC; Chromones; Flavonoids; Insulin-Like Growth Factor I; Mesenchymal Stem Cells; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Inbred Lew; Receptors, CXCR4; Signal Transduction; Wortmannin | 2007 |
Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Hepatocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Tyrphostins; Wortmannin | 2007 |
Differential expression and activity of matrix metalloproteinase-2 and -9 in the calreticulin deficient cells.
Topics: Androstadienes; Animals; Blotting, Western; Calreticulin; Cell Line; Embryonic Structures; Fibroblasts; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Developmental; Immunohistochemistry; Insulin; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Wortmannin | 2007 |
Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells.
Topics: Androstadienes; Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastric Mucins; Gastric Mucosa; Ginkgolides; Lactones; Leptin; Lipopolysaccharides; Organophosphonates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Wortmannin | 2007 |
Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway.
Topics: Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemotaxis, Leukocyte; Complement C5a; Enzyme Inhibitors; Flavonoids; Humans; In Vitro Techniques; Macrophage Inflammatory Proteins; Macrophages; Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Protein Transport; Salvia; Signal Transduction; Wortmannin | 2007 |
Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin | 2007 |
Participation of phosphatidyl inositol 3-kinase/protein kinase B and ERK1/2 pathways in interleukin-1beta stimulation of lactate production in Sertoli cells.
Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Interleukin-1beta; L-Lactate Dehydrogenase; Lactates; Male; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Sirolimus; Stimulation, Chemical; Transferrin; Wortmannin | 2007 |
Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors.
Topics: Aldosterone; Androstadienes; Androstenes; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Estradiol; Flavonoids; Humans; Medroxyprogesterone Acetate; Mifepristone; Nitric Oxide; Nitric Oxide Synthase Type III; Progesterone; Receptors, Mineralocorticoid; Receptors, Progesterone; Signal Transduction; Time Factors; Wortmannin | 2007 |
Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance.
Topics: Activins; Androstadienes; Animals; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Interleukin-1beta; Male; Mice; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; RNA, Messenger; Sertoli Cells; Signal Transduction; Spermatogonia; Stem Cells; Testosterone; Transcription Factors; Triiodothyronine; Tumor Necrosis Factor-alpha; Wortmannin | 2007 |
IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
Topics: Androstadienes; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biological Transport; Cell Line; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Immunohistochemistry; Indoles; Insulin-Like Growth Factor I; Isoquinolines; Male; Maleimides; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neurons; Oligonucleotides, Antisense; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Recombinant Proteins; Stroke; Sulfonamides; Wortmannin | 2007 |
Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.
Topics: Androstadienes; Animals; Argon; Atractyloside; Cardiotonic Agents; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heart Ventricles; Helium; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neon; Noble Gases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Wortmannin | 2007 |
Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.
Topics: Adenine; Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; bcl-X Protein; Beclin-1; Cell Line, Tumor; Cell Proliferation; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Indoles; Membrane Potential, Mitochondrial; Membrane Proteins; Microtubule-Associated Proteins; Molecular Structure; Phenols; Phosphatidylethanolamines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-raf; ras Proteins; Wortmannin | 2007 |
Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line; Cells, Cultured; Chondrocytes; Chromones; Enzyme Induction; Enzyme Inhibitors; Enzymes; Flavonoids; Humans; Imidazoles; Interferon-gamma; Leptin; MAP Kinase Kinase 1; Morpholines; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Wortmannin | 2007 |
Insulin signaling stimulates insulin transport by bovine aortic endothelial cells.
Topics: Androstadienes; Animals; Aorta; Cattle; Caveolin 1; Cells, Cultured; Endothelial Cells; Flavonoids; Genistein; Insulin; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Transport; Pyrazoles; Pyrimidines; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha; Wortmannin | 2008 |
Effects of tanshinone VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts.
Topics: Androstadienes; Animals; Atrial Natriuretic Factor; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Insulin-Like Growth Factor I; Leucine; Male; Molecular Structure; Myocytes, Cardiac; Phenanthrenes; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin | 2008 |
In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.
Topics: Amino Acid Transport System ASC; Androstadienes; Blotting, Western; Caco-2 Cells; Cell Membrane; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamine; Humans; Minor Histocompatibility Antigens; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Sodium; Time Factors; Tyrphostins; Up-Regulation; Wortmannin | 2008 |
Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3beta signaling in endothelial cells.
Topics: Androstadienes; Animals; Binding Sites; Blotting, Western; Cell Line; DNA-Binding Proteins; Endothelial Cells; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin; Lithium Chloride; Luciferases; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Swine; Transcription Factors; Transfection; Wortmannin | 2008 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chromones; Down-Regulation; Flavonoids; Humans; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multiprotein Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Invasiveness; Niacinamide; Nitriles; Phenylurea Compounds; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction; Sirolimus; Skin Neoplasms; Sorafenib; TOR Serine-Threonine Kinases; Transcription Factors; Wortmannin | 2008 |
Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation.
Topics: Amino Acid Transport System A; Amino Acid Transport Systems; Amino Acids; Androstadienes; Animals; Anthracenes; Cell Line; Chloroquine; Cycloheximide; Dactinomycin; Flavonoids; Insulin; Insulin Antagonists; Muscle, Skeletal; Osmotic Pressure; Protein Synthesis Inhibitors; Rats; Up-Regulation; Wortmannin | 2009 |
Granule formation in NGF-cultured mast cells is associated with expressions of pyruvate kinase type M2 and annexin I proteins.
Topics: Androstadienes; Animals; Annexin A1; Carbazoles; Cell Line, Tumor; Chromones; Cytoplasmic Granules; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Female; Flavonoids; Humans; Immunoblotting; Indole Alkaloids; Mast Cells; Mice; Mice, Inbred BALB C; Microscopy, Electron; Morpholines; Nerve Growth Factor; Phosphorylation; Pyruvate Kinase; RNA, Small Interfering; Transfection; Tumor Necrosis Factor-alpha; Wortmannin | 2008 |
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
Topics: Anabolic Agents; Androstadienes; Animals; Cattle; Cell Proliferation; Cells, Cultured; Culture Media; Estradiol; Estrogen Antagonists; Flavonoids; Fulvestrant; Gene Expression; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Receptor, IGF Type 1; Receptors, Androgen; Receptors, Estrogen; RNA, Messenger; Satellite Cells, Skeletal Muscle; Trenbolone Acetate; Wortmannin | 2008 |
Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.
Topics: Androstadienes; Cells, Cultured; Chemotaxis; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Isoxazoles; Killer Cells, Natural; Lysophospholipids; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Propionates; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid; Wortmannin | 2008 |
Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells.
Topics: Androstadienes; Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Chromones; Flavonoids; Ghrelin; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Wortmannin | 2008 |
Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation.
Topics: Adenine; Androstadienes; Aorta; Carbazoles; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Flavonoids; Ghrelin; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Wortmannin | 2008 |
Up-regulation of placental leptin by human chorionic gonadotropin.
Topics: Androstadienes; Cell Line, Tumor; Cesarean Section; Choriocarcinoma; Chorionic Gonadotropin; Delivery, Obstetric; Female; Flavonoids; Humans; Leptin; Placenta; Pregnancy; Promoter Regions, Genetic; Recombinant Proteins; Trophoblasts; Up-Regulation; Wortmannin | 2009 |
Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway.
Topics: Androstadienes; Blood Glucose; Body Mass Index; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Female; Flavonoids; Glucose; Humans; Insulin; Interleukin-8; Leukocytes; Male; Monocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin; Young Adult | 2008 |
Induction of copper/zinc-superoxide dismutase by CCL5/CCR5 activation causes tumour necrosis factor-alpha and reactive oxygen species production in macrophages.
Topics: Androstadienes; Animals; Cell Line; Chemokine CCL5; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Macrophages; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; Mice; NF-kappaB-Inducing Kinase; Nitric Oxide; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Receptors, CCR5; Superoxide Dismutase; Superoxide Dismutase-1; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation; Wortmannin | 2009 |
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake.
Topics: Alloxan; Androstadienes; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Colchicine; Cycloheximide; Diabetes Mellitus, Experimental; Disaccharides; Disease Models, Animal; Dose-Response Relationship, Drug; Flavones; Flavonoids; Glucose; Hyperglycemia; Indoles; Insulin; Insulin Secretion; Magnoliopsida; Male; Muscle, Skeletal; Plant Leaves; Rats; Rats, Wistar; Tissue Distribution; Wortmannin | 2009 |
P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.
Topics: Adenosine Diphosphate; Androstadienes; Animals; Apoptosis; Astrocytes; Brain Injuries; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gliosis; Male; MAP Kinase Signaling System; Nucleus Accumbens; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; Pyridoxal Phosphate; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Up-Regulation; Wortmannin | 2009 |
TGF-beta effects on airway smooth muscle cell proliferation, VEGF release and signal transduction pathways.
Topics: Androstadienes; Anthracenes; Cell Proliferation; Cells, Cultured; Dexamethasone; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glucocorticoids; Humans; Lung; MAP Kinase Kinase 4; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Signal Transduction; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Wortmannin | 2009 |
Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells.
Topics: Androstadienes; Animals; Anthracenes; Cell Line, Transformed; Cisplatin; Coculture Techniques; Cytokines; Cytotoxicity, Immunologic; Flavonoids; Inflammation Mediators; Macrophage Activation; Macrophages, Peritoneal; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Nitric Oxide; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Wortmannin | 2009 |
Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose.
Topics: Aminoimidazole Carboxamide; Androstadienes; Animals; Flavonoids; Glucose; In Vitro Techniques; Insulin; Male; Microscopy, Interference; Neurons; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Ribonucleotides; Ventromedial Hypothalamic Nucleus; Wortmannin | 2009 |
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Transcriptional activation of the mixed lineage leukemia-p27Kip1 pathway by a somatostatin analogue.
Topics: Adult; Androstadienes; Antineoplastic Agents, Hormonal; Base Sequence; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p27; Endocrine Gland Neoplasms; Female; Flavonoids; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Octreotide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Neoplasms; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Transcriptional Activation; Wortmannin | 2009 |
Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle.
Topics: Adjuvants, Immunologic; Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Glycogen; Glycogen Synthase Kinase 3; Hypoglycemic Agents; Insulin; Insulin Antagonists; Kaempferols; Lithium Chloride; Male; Marine Toxins; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Phosphatase 1; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 2009 |
Apelin protects heart against ischemia/reperfusion injury in rat.
Topics: Androstadienes; Animals; Apelin Receptors; Blotting, Western; Cell Death; Cells, Cultured; Flavonoids; Intercellular Signaling Peptides and Proteins; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Wortmannin | 2009 |
Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Androstadienes; Blotting, Western; Cell Cycle Proteins; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-4E; Female; Flavonoids; Humans; Leptin; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Placenta; Pregnancy; Protein Biosynthesis; Protein Kinase Inhibitors; Signal Transduction; Trophoblasts; Wortmannin | 2009 |
Scratch wound closure of C2C12 mouse myoblasts is enhanced by human platelet lysate.
Topics: Androstadienes; Animals; Blood Platelets; Cell Line; Cell Movement; Chemotaxis; Complex Mixtures; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Mice; Myoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Wortmannin; Wound Healing | 2009 |
Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.
Topics: Androstadienes; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Tyrphostins; Wortmannin | 2009 |
Basic fibroblast growth factor increases intracellular magnesium concentration through the specific signaling pathways.
Topics: Androstadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Endothelial Cells; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Humans; Imidazoles; Intracellular Space; Magnesium; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrrolidinones; Signal Transduction; Tyrphostins; Wortmannin | 2009 |
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Topics: Androstadienes; Anthracenes; Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Genistein; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Uterine Cervical Neoplasms; Wortmannin | 2009 |
Angiogenic activity of sesamin through the activation of multiple signal pathways.
Topics: Androstadienes; Animals; Antioxidants; Cell Adhesion Molecules; Cells, Cultured; Dioxoles; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesion Kinase 1; Humans; Lignans; Mice; Mice, Inbred BALB C; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factor A; Wortmannin | 2010 |
Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis.
Topics: Androstadienes; Animals; Carbachol; Cell Line; Chlorides; Colforsin; Enterocolitis; Epithelial Cells; Flavonoids; Humans; Leptin; Male; MAP Kinase Signaling System; Methotrexate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Wortmannin | 2010 |
Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells.
Topics: Androstadienes; Endothelial Cells; Endothelium; Flavonoids; Humans; Imidazolidines; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Umbilical Veins; Wortmannin | 2010 |
C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.
Topics: Androstadienes; Animals; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Female; Flavonoids; Interleukin-10; Interleukin-12; Lipopolysaccharides; Mice; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases; Toll-Like Receptors; Wortmannin | 2011 |
Mild stretch activates cPLA2 in alveolar type II epithelial cells independently through the MEK/ERK and PI3K pathways.
Topics: Androstadienes; Butadienes; Calcium; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorometry; Group IV Phospholipases A2; Humans; Immunoblotting; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A2, Cytosolic; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stress, Mechanical; Time Factors; Wortmannin | 2011 |
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Psychological; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Injections, Intraventricular; Isoquinolines; Male; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Sulfonamides; Wortmannin | 2011 |
Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice.
Topics: Androstadienes; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Granulocyte Colony-Stimulating Factor; Humans; Hyperalgesia; Imidazoles; Injections, Spinal; Injections, Subcutaneous; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mice; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Recombinant Proteins; Spinal Cord; Wortmannin | 2011 |
Insulin targets the Na(+)/K(+) ATPase in enterocytes via PI3K, PKC, and MAPKS.
Topics: Androstadienes; Caco-2 Cells; Dose-Response Relationship, Drug; Enterocytes; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Insulin; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Wortmannin | 2011 |
Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells.
Topics: Androstadienes; Anilides; Calcium-Calmodulin-Dependent Protein Kinases; CD36 Antigens; Cell Line; Dermis; Endothelial Cells; Fatty Acids, Omega-3; Flavonoids; Gene Expression Regulation; Humans; Insulin; Insulin Resistance; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; PPAR alpha; PPAR gamma; Receptors, Scavenger; Wortmannin | 2011 |
Differential modulation of brainstem phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55,212-2 centrally mediated pressor response in conscious rats.
Topics: Androstadienes; Animals; Benzoxazines; Blood Pressure; Blotting, Western; Brain Stem; Calcium Channel Blockers; Enzyme Inhibitors; Flavonoids; Heart Rate; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Solitary Nucleus; Wortmannin | 2012 |
Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide.
Topics: 3T3 Cells; Androstadienes; Animals; Anthracenes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Escherichia coli; Flavonoids; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Osteoblasts; Osteoprotegerin; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas endodontalis; RANK Ligand; Real-Time Polymerase Chain Reaction; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Wortmannin | 2011 |
Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.
Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Microglia; Nociception; Nociceptive Pain; Pain; Pain Measurement; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Spinal Cord; Wortmannin | 2012 |
Lipopolysaccharide-induced stem cell factor messenger RNA expression and production in odontoblast-like cells.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Line; Dexamethasone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation; Glucocorticoids; Humans; Imidazoles; Indoles; Lipopolysaccharides; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Odontoblasts; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Stem Cell Factor; Time Factors; Wortmannin | 2012 |
Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.
Topics: Androstadienes; Apoptosis; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Ovarian Neoplasms; Phenotype; Phosphorylation; Proteolysis; Receptors, Interleukin-6; Signal Transduction; Wortmannin | 2012 |
Growth factor regulation of intracellular pH homeostasis under hypoxic conditions in isolated equine articular chondrocytes.
Topics: Acid-Base Equilibrium; Androstadienes; Animals; Cartilage, Articular; Chondrocytes; Flavonoids; Homeostasis; Horses; Hydrogen-Ion Concentration; Hypoxia; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Oxygen; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Reactive Oxygen Species; Transforming Growth Factor beta; Wortmannin | 2013 |
KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin | 2013 |
Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Cell Survival; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Heme Oxygenase-1; Humans; Indoles; Maleimides; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2013 |
Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.
Topics: Adult; Aged; Androstadienes; Animals; Biological Transport; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Flavonoids; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Humans; Insulin; Male; Mice; Mice, Knockout; Middle Aged; Molecular Targeted Therapy; Muscle Cells; Muscle, Skeletal; Obesity; Peptides; Receptors, Bombesin; Sirolimus; Wortmannin | 2013 |
Suppression of apoptosis by pseudorabies virus Us3 protein kinase through the activation of PI3-K/Akt and NF-κB pathways.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Dimethyl Sulfoxide; DNA Damage; Flavonoids; Herpesvirus 1, Suid; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pseudorabies; Signal Transduction; Swine; Viral Proteins; Wortmannin | 2013 |
Effect of atrial natriuretic peptide on reactive oxygen species-induced by hydrogen peroxide in THP-1 monocytes: role in cell growth, migration and cytokine release.
Topics: Androstadienes; Atrial Natriuretic Factor; Cell Line; Cell Movement; Cell Proliferation; Cytokines; Flavonoids; Gene Expression; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Monocytes; NADPH Oxidases; Onium Compounds; Peptide Fragments; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reactive Oxygen Species; Signal Transduction; Wortmannin | 2013 |
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
Topics: Androstadienes; Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; HLA-A Antigens; Humans; Lapatinib; MAP Kinase Signaling System; Neoplasm Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Wortmannin | 2013 |
Endothelin-1 stimulates resistin gene expression.
Topics: 3T3-L1 Cells; Adipose Tissue; Androstadienes; Animals; Anthracenes; Butadienes; Chromones; Dactinomycin; Endothelin-1; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Morpholines; Nitriles; Oligopeptides; Piperidines; Proto-Oncogene Proteins c-akt; Resistin; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Wortmannin | 2014 |
Osteoblastic differentiation of stromal ST-2 cells from octacalcium phosphate exposure via p38 signaling pathway.
Topics: Alkaline Phosphatase; Androstadienes; Animals; Calcium Phosphates; Cell Differentiation; Cell Line; Cell Proliferation; Flavonoids; Imidazoles; Mice; Molecular Structure; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stromal Cells; Wortmannin | 2014 |
IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation.
Topics: Androstadienes; Animals; Cell Cycle; Cell Proliferation; Cell Survival; Flavonoids; Humans; Laminin; MAP Kinase Signaling System; Mesenchymal Stem Cells; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Signal Transduction; Tissue Engineering; Tissue Scaffolds; Wortmannin | 2014 |
Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.
Topics: Adenylyl Cyclases; Adiponectin; Androstadienes; Animals; Anisoles; Arginine; Colforsin; Consciousness; Cyclic AMP; Cyclohexanes; Flavonoids; Hypotension; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase Type I; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Wortmannin | 2014 |
Apocynum venetum leaf attenuates myocardial ischemia/reperfusion injury by inhibiting oxidative stress.
Topics: Androstadienes; Antioxidants; Apocynum; Apoptosis; Creatine Kinase; Drugs, Chinese Herbal; Flavonoids; Ischemic Preconditioning; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase 3; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neuroprotective Agents; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phytotherapy; Plant Leaves; Superoxide Dismutase; Wortmannin | 2015 |
Identification of intracellular pathways through which TGF-β1 upregulates URG-4/URGCP gene expression in hepatoma cells.
Topics: Androstadienes; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Male; MAP Kinase Kinase 1; MAP Kinase Signaling System; Neoplasm Proteins; RNA, Messenger; Transfection; Transforming Growth Factor beta1; Up-Regulation; Wortmannin | 2016 |
Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways.
Topics: Androstadienes; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hyperthermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; MAP Kinase Signaling System; Mice; Neoplasm Recurrence, Local; Phosphorylation; Proto-Oncogene Proteins c-akt; Small Cell Lung Carcinoma; Wortmannin | 2016 |
Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies.
Topics: Androstadienes; Animals; Carrier Proteins; Chromones; Citrulline; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Malnutrition; Mechanistic Target of Rapamycin Complex 1; Mitogen-Activated Protein Kinases; Morpholines; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2017 |
MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma.
Topics: Androstadienes; Animals; Cell Line, Tumor; Endometrial Neoplasms; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Lentivirus; Mice; Mice, Nude; MicroRNAs; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Transplantation; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; TOR Serine-Threonine Kinases; Transfection; Vascular Endothelial Growth Factor A; Wortmannin | 2017 |
Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes.
Topics: Androstadienes; Angelica; Animals; Aorta; Cell Line; Cell Movement; Cell Proliferation; Diabetes Mellitus, Experimental; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Medicine, Chinese Traditional; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Plant Extracts; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Wortmannin; Wound Healing | 2017 |
Insulin Influences LPS-Induced TNF-α and IL-6 Release Through Distinct Pathways in Mouse Macrophages from Different Compartments.
Topics: Androstadienes; Animals; Bone Marrow Cells; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental; Flavonoids; Insulin; Interleukin-6; Lipopolysaccharides; Macrophages; Macrophages, Alveolar; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin | 2017 |
Sorafenib stimulates human skin type mast cell degranulation and maturation.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Antineoplastic Agents; Apoptosis; Biopsy; Cell Count; Cell Degranulation; Cell Proliferation; Drug Eruptions; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Male; Mast Cells; Middle Aged; Niacinamide; Organ Culture Techniques; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Signal Transduction; Skin; Sorafenib; Stem Cell Factor; Vascular Endothelial Growth Factor A; Wortmannin; Young Adult | 2017 |
Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467.
Topics: Androstadienes; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line, Tumor; Flavonoids; HEK293 Cells; Humans; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Neurons; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Serine; Signal Transduction; Wortmannin | 2018 |
Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cerebral Cortex; Chromones; Cortical Excitability; Electric Stimulation; Flavonoids; GABAergic Neurons; Glucose; Inhibitory Postsynaptic Potentials; Janus Kinase 2; Leptin; Mitogen-Activated Protein Kinase Kinases; Morpholines; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Pyrazoles; Pyrimidines; Rats; Rats, Transgenic; Rotenone; Signal Transduction; Synaptic Transmission; Wortmannin | 2019 |
The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells.
Topics: Angiogenesis Inhibitors; Apelin; Apelin Receptors; Flavonoids; Gene Expression Regulation; Half-Life; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Signaling Peptides and Proteins; Promoter Regions, Genetic; Quinazolines; RNA Stability; RNA, Messenger; Signal Transduction; Wortmannin | 2019 |
Evaluation of the MA-10 cell line as a model of insl3 regulation and Leydig cell function.
Topics: Animals; Cell Line; Chorionic Gonadotropin; Flavonoids; Gene Expression Regulation; Insulin; Isoquinolines; Leydig Cells; Male; Mice; Nuclear Receptor Subfamily 4, Group A, Member 1; Perylene; Proteins; Signal Transduction; Sulfonamides; Testosterone; Wortmannin | 2019 |