pd 98059 and tretinoin

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

Topics: Alkaloids; Benzophenanthridines; Butyrates; Butyric Acid; Calcitriol; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cycloheximide; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Osteopontin; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tretinoin

Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactinomycin; DNA, Complementary; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Hydroquinones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Okadaic Acid; Phenols; Proto-Oncogene Proteins c-raf; Quinones; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured

Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Flavonoids; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine

Topics: Antineoplastic Agents; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Differentiation; Cell Division; Drosophila Proteins; Electrophysiology; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Ion Channel Gating; Neuroblastoma; Neurons; Phosphoprotein Phosphatases; Potassium Channels; Potassium Channels, Inwardly Rectifying; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; ras Guanine Nucleotide Exchange Factors; ras-GRF1; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Transfection; Tretinoin; Tumor Cells, Cultured

Topics: Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Survival; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factors; Neurites; Neuroblastoma; Neuroprotective Agents; Neurotrophin 3; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Receptor, trkC; Receptors, Nerve Growth Factor; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin; Tumor Cells, Cultured

Topics: Cells, Cultured; Cycloheximide; Drug Synergism; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; Pyridines; Receptors, Retinoic Acid; Retinoid X Receptors; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcription Factors; Tretinoin

Topics: Calcitriol; Cell Differentiation; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocytes; HL-60 Cells; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Mitogen-Activated Protein Kinases; Monocytes; Nitroblue Tetrazolium; Pyrimidines; Tretinoin; Tumor Cells, Cultured

Topics: Antineoplastic Agents; Biomarkers; Blotting, Western; Calcitriol; Cell Cycle; Cell Differentiation; Cell Division; Cell Nucleus; Culture Media, Serum-Free; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G1 Phase; HL-60 Cells; Humans; Immunoblotting; Kinetics; Lipopolysaccharide Receptors; Macrophage-1 Antigen; Mitogen-Activated Protein Kinases; Models, Biological; Monocytes; Phenotype; Phosphorylation; Time Factors; Tretinoin

Topics: Androstadienes; Antineoplastic Agents; Biomarkers; Cell Differentiation; Diterpenes; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Interferon-gamma; Leukemia, Myeloid; Lipopolysaccharide Receptors; Maleimides; Monocytes; Naphthalenes; Plant Growth Regulators; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells; Virulence Factors, Bordetella; Wortmannin

Topics: Animals; Calcineurin; Carcinoma, Embryonal; Cell Differentiation; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Transcription Factors; Tretinoin; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzophenanthridines; Calcitriol; Capsaicin; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Maleimides; Phenanthridines; Protein Kinase C; Signal Transduction; Tretinoin

Topics: Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Inhibitory Concentration 50; Interphase; Maleimides; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Naphthalenes; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Staurosporine; Transcription Factors; Tretinoin

Topics: Adipocytes; Animals; Butadienes; Cell Lineage; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Myocardium; Neurons; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Binding; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tretinoin

Topics: Animals; Blotting, Northern; Cell Line; Enzyme Activation; Flavonoids; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tretinoin; Up-Regulation

Topics: Activin Receptors, Type I; Activin Receptors, Type II; Adenoviridae; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cartilage, Articular; Cattle; Cell Differentiation; Cells, Cultured; Chondrocytes; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Protein Serine-Threonine Kinases; Proteins; Pyridines; Receptors, Growth Factor; Signal Transduction; Smad Proteins; Smad1 Protein; Smad5 Protein; Smad6 Protein; Trans-Activators; Transforming Growth Factor beta; Tretinoin

Topics: alpha Catenin; Animals; beta Catenin; Cadherins; Cartilage; Cells, Cultured; Chick Embryo; Chondrogenesis; Collagen; Cytochalasin D; Cytoskeletal Proteins; Enzyme Inhibitors; Flavonoids; Limb Buds; Mesoderm; Mitogen-Activated Protein Kinases; Protein Kinase C; Proteoglycans; Trans-Activators; Tretinoin

Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Enzyme Inhibitors; Flavonoids; G2 Phase; Gene Expression Profiling; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; Peptide Fragments; S Phase; Signal Transduction; Tretinoin; Tumor Cells, Cultured

Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Western; Brain; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cyclin D1; Cycloheximide; Cysteine Endopeptidases; DNA-Binding Proteins; DNA, Complementary; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Flavonoids; Green Fluorescent Proteins; Humans; Luminescent Proteins; Lung; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphorylation; Plasmids; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rats; Retinoids; Time Factors; Transcription Factors; Transcription, Genetic; Tretinoin; Ubiquitin

Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Immune Sera; Insulin; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Signal Transduction; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin

Topics: Cell Differentiation; Cell Line, Tumor; Cholesterol; Culture Media, Serum-Free; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Lipoproteins, HDL; Membrane Microdomains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Growth Factors; Neuroblastoma; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Signal Transduction; Time Factors; Transfection; Tretinoin

Topics: Alitretinoin; Animals; Binding Sites; Choline-Phosphate Cytidylyltransferase; DNA, Complementary; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genes, Dominant; Immunoblotting; Immunoprecipitation; Lung; Mice; Mitogen-Activated Protein Kinase 1; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Phosphatidylcholines; Phosphorylation; Proline; Protein Biosynthesis; Protein Structure, Tertiary; Receptors, Steroid; Sterols; Surface-Active Agents; Time Factors; Transcription, Genetic; Transfection; Tretinoin

Topics: Butadienes; Cadherins; Cell Differentiation; Cell Line; Cell Line, Tumor; Central Nervous System; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genistein; Humans; Immunoblotting; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Nitriles; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Threonine; Time Factors; Tretinoin; Up-Regulation

Topics: CD11b Antigen; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Flow Cytometry; HL-60 Cells; Humans; Morpholines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sensitivity and Specificity; Tretinoin

Topics: Apoptosis; Base Sequence; Cell Proliferation; Dose-Response Relationship, Drug; Flavonoids; Heat-Shock Proteins; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Transport Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; Time Factors; Transcriptional Activation; Tretinoin

Topics: Animals; Benzoates; Biphenyl Compounds; Blotting, Northern; Blotting, Western; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Flavonoids; Humans; Interleukin-1beta; Male; MAP Kinase Kinase 1; Mesangial Cells; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Retinoid X Receptors; Retinoids; RNA, Messenger; Time Factors; Tretinoin; Up-Regulation

Topics: Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Flow Cytometry; Humans; Indoles; Interphase; Maleimides; Methylmercury Compounds; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroblastoma; Phosphorylation; Protein Kinase C-alpha; Time Factors; Tretinoin

Topics: Alitretinoin; Calcium Signaling; Cell Line; Chemokines; Chemotaxis, Leukocyte; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CCR1; Receptors, CCR2; Receptors, Chemokine; RNA, Messenger; Tretinoin

Topics: Aldehyde Dehydrogenase; Androgens; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Estradiol; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Male; Metribolone; Prostatic Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Retinaldehyde; Retinoic Acid 4-Hydroxylase; RNA, Messenger; RNA, Small Interfering; src-Family Kinases; Tretinoin

Topics: Alitretinoin; Apoptosis; Blotting, Western; Butadienes; Cell Proliferation; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phosphorylation; Retinoid X Receptor alpha; Tretinoin

Topics: Cell Line, Tumor; Flavonoids; Flow Cytometry; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Protein Kinase Inhibitors; Pyridines; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tretinoin

Topics: Breast Neoplasms; Catalytic Domain; Chromatin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Estrogens; Female; Flavonoids; Histone Demethylases; Histones; Humans; Isoquinolines; MAP Kinase Signaling System; MCF-7 Cells; Methylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Sulfonamides; Transcription, Genetic; Tretinoin

Topics: Cell Differentiation; Flavonoids; HL-60 Cells; Humans; NFATC Transcription Factors; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-raf; Receptors, CXCR5; Tretinoin