pd 98059 and transforming growth factor beta

pd 98059 has been researched along with transforming growth factor beta in 124 studies

Research

Studies (124)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (8.87)	18.2507
2000's	104 (83.87)	29.6817
2010's	9 (7.26)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bono, F; Herbert, JM; Lamarche, I	1
Chang, NS	1
Greene, RM; Lloyd, MR; Potchinsky, MB; Weston, WM	1
Li, WQ; Zafarullah, M	1
Abrams, W; Ahmed, W; Bashir, M; Kucich, U; Mecham, R; Rosenbloom, J; Segade, F	1
Luo, J; Miller, MW	1
Itoh, H; Kaiura, TL; Kent, KC	1
Asselin, C; Boudreau, F; Désilets, A; Houde, M; Rivard, N; Yu, SJ	1
Hamaguchi, A; Iwao, H; Izumi, Y; Kim, S; Yamanaka, S; Zhan, Y	1
Kivinen, L; Laiho, M	1
Polk, DB; Tong, W	1
Goto, D; Iwamoto, I; Kato, M; Mamura, M; Nakao, A; Saito, Y	1
Bar-Peled, O; Bristol, LA; Coccia, C; Griffin, JW; Ho, TW; Jin, L; Johnson, E; Li, Y; Milbrandt, J; Rothstein, JD	1
Mulder, KM; Yue, J	1
Cochet, C; Fahmi, H; Hmama, Z; Joab, I; Opolon, P	1
Gressner, AM; Jansson, JO; Skrtic, S; Wallenius, K	1
Byun, DS; Chi, SG; Park, BJ; Park, JH; Park, JI	1
Fanburg, BL; Finlay, GA; Paulson, KE; Thannickal, VJ	1
Frontelo, P; Iglesias, M; Martínez, J; Quintanilla, M; Santibáñez, JF	1
Lindvall, M; Schiött, A; Sjögren, HO	1
Dryer, SE; Lhuillier, L	2
Bae, YS; Choi, I; Ha, KS; Han, SH; Im, JY; Ju, HR; Junn, E; Kang, HS; Lee, KN; Lee, TH; Lee, ZW; Rhee, SG	1
Fan, WH; Karnovsky, MJ	1
Chatziantoniou, C; Dussaule, JC; Fakhouri, F; Tharaux, PL	1
Abraham, JA; Chen, MM; Joly, AH; Lam, A; Schreiner, GF	1
Christopher, JT; Douillet, CD; Jaffa, AA; Mayfield, RK; Trojanowska, ME; Velarde, V	1
Chen, S; Cruz, MCI; Hong, SW; Isono, M; Ziyadeh, FN	1
Gon, Y; Hashimoto, S; Horie, T; Maruoka, S; Matsumoto, K; Takeshita, I	1
Churg, A; Dai, J	1
Atfi, A; Baron, R; Faucheu, C; Gallea, S; Huet, L; Kawai, S; Lallemand, F; Ramez, V; Rawadi, G; Roman-Roman, S; Spinella-Jaegle, S	1
Li, H; Wong, WS	1
Hoelzer, D; Hofmann, WK; Kalina, U; Kauschat, D; Koschmieder, S; Ottmann, OG; Wagner, S	1
Fromigué, O; Haÿ, E; Lemonnier, J; Marie, PJ	1
Graziano, K; Logsdon, CD; Nicke, B; Pham, T; Schaefer, C; Simeone, DM; Zhang, L	1
Ballas, K; Hoelzer, D; Hofmann, WK; Kalina, U; Koschmieder, S; Kunert, J; Ottmann, OG; Seipelt, G; Wagner, S	1
Attisano, L; Blanchette, F; Dubois, CM; Grondin, F; Rivard, N; Rudd, P	1
Battaglia, G; Bruno, V; Cuomo, L; D'Onofrio, M; De Blasi, A; Di Iorio, P; Kingston, AE; Ngomba, RT; Nicoletti, F; Orzi, F; Storto, M	1
Akamatsu, S; Dohi, S; Kozawa, O; Matsuno, H; Tanabe, K; Uematsu, T; Yamamoto, T	1
Endo, Y; Fujita, T; Hori, S; Kawada, M; Mizuno, M; Nasu, J; Okada, H; Takeuchi, K; Tsuji, T; Uesu, T	1
Iacovitti, L; Jung, JW; Stull, ND	1
Pouysségur, J; Viñals, F	1
Chaponnier, C; Dugina, V; Fontao, L; Gabbiani, G; Vasiliev, J	1
Fehrenbach, H; Gressner, AM; Kasper, M; Weiskirchen, R	1
Ma, ZJ; Yamaguchi, M	1
Barnett, MW; Davies, JA; Fisher, CE; Michael, L	1
Baxter, GF; Brar, BK; Latchman, DS; Mocanu, MM; Yellon, DM	1
Chen, H; Li, D; Mehta, JL	1
Nihei, H; Nitta, K; Ohashi, T; Suzuki, H; Uchida, K; Yumura, W	1
Higgins, PJ; Hordines, J; Kutz, SM; McKeown-Longo, PJ	1
Deb, DK; Platanias, LC; Sassano, A; Uddin, S; Varga, J; Verma, A; Wickrema, A	1
Fujita, T; Fukumoto, S; Kato, S; Miyazono, K; Suzawa, M; Takeuchi, Y; Tamura, Y	1
Hatakeyama, D; Ito, H; Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Shibata, T; Tatematsu, N; Uematsu, T	1
Ouadrhiri, Y; Pilette, C; Renauld, JC; Sibille, Y; Staquet, P; Vaerman, JP; Van Snick, J	1
Igarashi, A; Yamaguchi, M	1
Chihara, K; Kaji, H; Sowa, H; Sugimoto, T; Yamaguchi, T	1
Akiyama-Uchida, Y; Ashizawa, N; Kikuchi, H; Ohtsuru, A; Seto, S; Tsukazaki, T; Yamashita, S; Yano, K	1
Fabra, A; Guerrero, J; Martínez, J; Quintanilla, M; Santibáñez, JF	1
Akman, HO; Batuman, OA; Hussain, MM; Kedees, MH; Singh, K; Vakil, V	1
Sanders, PW; Ying, WZ	1
Hashimoto, N; Higuchi, C; Itoh, K; Kuriyama, K; Myoui, A; Yoshikawa, H; Yoshioka, K	1
Fujii, M; Miyazono, K; Nishihara, A; Reddi, AH; Sampath, TK	1
Costanzo, FS; Cuda, G; Fratto, D; Grembiale, RD; Marsico, SA; Maselli, R; Pelaia, G; Tagliaferri, P; Vatrella, A	1
Danielson, KG; Modaressi, R; Rainville, AM; Roman-Blas, JA; Seghatoleslami, MR; Tuan, RS	1
Lee, JC; Shoba, LN	1
Churg, A; Dai, J; Vincent, R; Xie, C	1
Andriantsitohaina, R; Beretz, A; Chang, SJ; Chataigneau, M; Chataigneau, T; Keravis, T; Oak, MH; Schini-Kerth, VB; Stoclet, JC	1
Chen, S; Cohen, MP; Shea, E; Shearman, CW	1
Chen, HH; Song, JG; Zhao, S	1
Andoh, A; Bamba, S; Fujiyama, Y; Kim, S; Makino, J; Yasui, H	1
Akamatsu, S; Hatakeyama, D; Kozawa, O; Shibata, T; Tanabe, K; Tokuda, H; Yoshida, M	1
Kracklauer, MP; Schmidt, C; Sclabas, GM	1
Guerrero, J; Martínez, J; Olivares, D; Santibáñez, JF	1
Chang, YY; Sun, SH; Wang, CM	1
Damm, DL; Kapoun, AM; Lam, A; Liang, F; Munson, K; O'Young, G; Protter, AA; Quon, D; Schreiner, GF; White, RT	1
Chen, YQ; Shen, Q; Wang, D; Wang, MH	1
Andres, DA; Drahushuk, KM; Gonsiorek, EA; Higgins, D; Kim, IJ; Kim, WY; Lein, P	1
Chen, N; Dai, BB; Lu, J; Wang, WM; Zhao, Q	1
Kale, VP	1
Amarsanaa, J; Arakawa, Y; Hoshida, Y; Ijichi, H; Ikenoue, T; Imamura, T; Kanai, F; Kawabe, T; Kawakami, T; Miyagishi, M; Omata, M; Taira, K; Tanaka, Y; Tateishi, K; Yokosuka, O	1
Cheng, LJ; Huang, HC; Liang, Y	1
Kanayama, N; Kobayashi, H; Suzuki, M; Terao, T	1
Inagaki, K; Kanayama, N; Kobayashi, H; Kondo, T; Kurita, N; Matsuzaki, H; Sekino, H; Suzuki, M; Terao, T; Wakahara, K; Yagyu, T	1
Hatamochi, A; Sato, M; Shegogue, D; Trojanowska, M; Yamazaki, S	1
Barsky, L; Buckley, S; Warburton, D; Weinberg, K	1
Aoki, Y; Kanai, H; Kawai-Kowase, K; Kurabayashi, M; Maeno, T; Nagai, R; Ohyama, Y; Oyama, Y; Sakamoto, H; Sato, H; Sato, M; Suga, T; Tamura, J	1
Kitamura, N; Miyazawa, K; Tanaka, T; Tsukada, Y	1
Ikejima, K; Rippe, RA; Sato, N; Tsukada, S; Westwick, JK	1
Brody, AR; Ferris, M; Pociask, D; Sullivan, DE	1
Ishisaki, A; Kanno, Y; Kozawa, O; Numata, O; Tokuda, H; Yoshida, M	1
Adler, G; Giehl, K; Menke, A; Nguyen-Tat, MD; Vogelmann, R; Wedlich, D	1
Huang, H; Li, J; Li, X; Li, Y; Liang, Y; Liu, S; Wang, H; Wang, L	1
Howe, KL; McKay, DM; Nazli, A; Reardon, C; Wang, A	1
Rawal, SY; Walters, JD	1
Herrera-Molina, R; Saud, K; Von Bernhardi, R	1
Aoki, H; Hama, K; Hanatsuka, K; Ishijima, T; Kita, H; Mashima, H; Miyata, T; Ohashi, A; Ohnishi, H; Osawa, H; Sato, K; Satoh, Y; Sugano, K; Tamada, K; Wada, S; Yamamoto, H; Yasuda, H	1
Cho, SJ; Elias, JA; Homer, RJ; Kang, HR; Kang, MJ; Lee, CG; Lee, PJ; Zhang, X	1
Cicha, I; Goppelt-Struebe, M; Graness, A	1
Cho, H; Hong, SI; Kim, MS; Kwak, HJ; Lee, HC; Moon, SI; Park, CM; Park, IC; Park, MJ; Rhee, CH	1
Lim, IJ; Longaker, MT; Phan, TT; Xia, W; Yang, GP	1
Huang, HC; Huang, YT; Kuo, YH; Kuo, YR; Lin, CL; Sun, YC; Wang, FS	1
Aoki, H; Hama, K; Kita, H; Ohnishi, H; Osawa, H; Sato, K; Shinozaki, S; Sugano, K; Tamada, K; Yamamoto, H	1
Bae, JS; Kim, IS; Kim, JE; Lee, BH; Park, JY; Park, RW	1
Abe, M; Funaba, M; Ikeda, T; Murakami, M; Nishino, Y; Ogawa, K; Sugino, H; Tsuchida, K	1
Alvarez-Munoz, P; Bernabéu, C; López-Novoa, JM; Obreo, J; Pandiella, A; Rodríguez-Barbero, A	1
Hong, HK; Kim, BC; Lee, HS; Song, CY	1
Birnbaumer, L; Edwards, RA; Hoang, B; Trinh, A	1
Lei, X; Nichols, RW; Sun, LZ; Yang, J	1
Carmona-Cuenca, I; Del Castillo, G; Fabregat, I; Fernández, M; Murillo, MM; Ortiz, C; Roncero, C; Sánchez, A	1
Bezouglaia, O; Demer, LL; Huang, MS; Lu, J; Morony, S; Tetradis, S; Tintut, Y; Tseng, W; Zhang, Z	1
Beck, SE; Cabral, JA; Cabrera, BL; Carethers, JM; Chow, JY; Quach, KT	1
Kim, DS; Shim, JW; Shim, JY; Shin, JH	1
Ampasala, D; Basson, MD; Suer, S; Walsh, MF	1
Bendel, AE; Brown, RE; Zenali, MJ; Zhang, PL	1
Bulgheresi, S; Emami, C; Mittal, R; Prasadarao, NV	1
Baarsma, HA; Gosens, R; Halayko, AJ; Heijink, IH; Meurs, H; Oenema, TA; Schmidt, M	1
Abe, K; Arai, F; Hiyama, A; Mochida, J; Nakajima, D; Sakai, D; Tanaka, M	1
Cao, X; Han, Y; Xu, S; Zhang, M	1
Hsu, SL; Hsueh, CM; Lin, LC; Liu, WC; Wu, CL	1
Jia, C; Jiang, Y; Lu, Y; Mi, Y; Ren, L; Song, W; Zhang, Y	1
Gibson, JS; Milner, PI; Robinson, R; Smith, HC; Wilkins, RJ	1
Boye, A; He, S; Jiang, Y; Kan, H; Wu, C; Yang, X; Yang, Y	1
Gao, W; Hwang, E; Lin, P; Ngo, HTT; Wang, Y; Yan, Z; Yi, TH	1
Bantug, G; Christofori, G; Diepenbruck, M; Hess, C; Ishay-Ronen, D; Ivanek, R; Kalathur, RKR; Morini, MF; Sugiyama, N; Tiede, S; Wang, J	1

Other Studies

124 other study(ies) available for pd 98059 and transforming growth factor beta

Article	Year
NGF exhibits a pro-apoptotic activity for human vascular smooth muscle cells that is inhibited by TGFbeta1. FEBS letters, 1997, Oct-27, Volume: 416, Issue:3 Topics: Androstadienes; Aorta; Apoptosis; Carbazoles; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Indole Alkaloids; Kinetics; MAP Kinase Kinase Kinase 1; Muscle, Smooth, Vascular; Nerve Growth Factors; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Time Factors; Transforming Growth Factor beta; Wortmannin	1997
Hyaluronidase enhancement of TNF-mediated cell death is reversed by TGF-beta 1. The American journal of physiology, 1997, Volume: 273, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Death; Cell Survival; Cytokines; Drug Synergism; Enzyme Inhibitors; Flavonoids; Humans; Hyaluronoglucosaminidase; Kinetics; L Cells; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1997
Selective modulation of MAP kinase in embryonic palate cells. Journal of cellular physiology, 1998, Volume: 176, Issue:2 Topics: Animals; Calcimycin; Carcinogens; Cells, Cultured; Cholera Toxin; Cyclic AMP; Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Fetus; Flavonoids; Ionophores; Isoquinolines; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Palate; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta	1998
Oncostatin M up-regulates tissue inhibitor of metalloproteinases-3 gene expression in articular chondrocytes via de novo transcription, protein synthesis, and tyrosine kinase- and mitogen-activated protein kinase-dependent mechanisms. Journal of immunology (Baltimore, Md. : 1950), 1998, Nov-01, Volume: 161, Issue:9 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinases; Cartilage, Articular; Cattle; Cells, Cultured; Dactinomycin; Dexamethasone; Flavonoids; Gene Expression Regulation; Nucleic Acid Synthesis Inhibitors; Oncostatin M; Peptides; Protein-Tyrosine Kinases; Signal Transduction; Stimulation, Chemical; Tissue Inhibitor of Metalloproteinase-3; Transcription, Genetic; Transforming Growth Factor beta	1998
Signaling pathway by which TGF-beta1 increases expression of latent TGF-beta binding protein-2 at the transcriptional level. Connective tissue research, 1998, Volume: 37, Issue:3-4 Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Latent TGF-beta Binding Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta	1998
Transforming growth factor beta1-regulated cell proliferation and expression of neural cell adhesion molecule in B104 neuroblastoma cells: differential effects of ethanol. Journal of neurochemistry, 1999, Volume: 72, Issue:6 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Ethanol; Flavonoids; Gene Expression Regulation, Neoplastic; Kinetics; Neural Cell Adhesion Molecules; Neuroblastoma; Protein Serine-Threonine Kinases; Transforming Growth Factor beta; Tumor Cells, Cultured	1999
The role of mitogen-activated protein kinase and protein kinase C in fibronectin production in human vascular smooth muscle cells. The Journal of surgical research, 1999, Jun-15, Volume: 84, Issue:2 Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibronectins; Flavonoids; Humans; Indoles; Maleimides; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Transforming Growth Factor beta	1999
Attenuation of haptoglobin gene expression by TGFbeta requires the MAP kinase pathway. Biochemical and biophysical research communications, 1999, Jun-16, Volume: 259, Issue:3 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dexamethasone; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gene Expression Regulation; Glucocorticoids; Haptoglobins; Rats; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Transforming Growth Factor beta	1999
Contribution of extracellular signal-regulated kinase to angiotensin II-induced transforming growth factor-beta1 expression in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hypertension; Male; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Transcription Factor AP-1; Transforming Growth Factor beta	1999
Ras- and mitogen-activated protein kinase kinase-dependent and -independent pathways in p21Cip1/Waf1 induction by fibroblast growth factor-2, platelet-derived growth factor, and transforming growth factor-beta1. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1999, Volume: 10, Issue:9 Topics: 3T3 Cells; Animals; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation, Enzymologic; Growth Substances; Kinetics; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; ras Proteins; RNA, Messenger; S Phase; Transforming Growth Factor beta	1999
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line. The American journal of physiology, 1999, Volume: 277, Issue:6 Topics: Animals; Cell Division; Cell Line, Transformed; Chemotaxis; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Matrix; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Intestines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Quinazolines; Transforming Growth Factor beta; Type C Phospholipases; Tyrphostins	1999
Ligation of the T cell receptor complex results in phosphorylation of Smad2 in T lymphocytes. Biochemical and biophysical research communications, 2000, Feb-05, Volume: 268, Issue:1 Topics: Animals; Antibodies, Monoclonal; Base Sequence; CD3 Complex; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; In Vitro Techniques; Jurkat Cells; MAP Kinase Kinase 1; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Receptors, Antigen, T-Cell; RNA, Messenger; Signal Transduction; Smad2 Protein; T-Lymphocytes; Trans-Activators; Transforming Growth Factor beta	2000
TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity. Experimental neurology, 2000, Volume: 161, Issue:2 Topics: Androstadienes; Animals; Axons; Chromones; Cloning, Molecular; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Humans; Kinetics; Morpholines; Motor Neurons; Nerve Growth Factors; Nerve Tissue Proteins; Neurturin; Nodal Protein; Organ Culture Techniques; Rats; Recombinant Proteins; Spinal Cord; Transforming Growth Factor beta; Wortmannin	2000
Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway. The Journal of biological chemistry, 2000, Oct-06, Volume: 275, Issue:40 Topics: Animals; Bacterial Proteins; Base Sequence; Cell Line; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fos-Related Antigen-2; Genes, Dominant; Genes, ras; Intestinal Mucosa; Kinetics; Liver; Luciferases; Lung; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mink; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; ras Proteins; Rats; Ribonucleases; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad4 Protein; Time Factors; Trans-Activators; Transcription Factor AP-1; Transcription Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta3	2000
Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway. Journal of virology, 2000, Volume: 74, Issue:13 Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Imidazoles; Immediate-Early Proteins; Kinetics; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protein Kinase C; Pyridines; RNA, Messenger; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured; Viral Proteins	2000
Characterization of hepatocyte-derived mitogenic activity on hepatic stellate cells. Liver, 2000, Volume: 20, Issue:2 Topics: Animals; Cattle; Cell Separation; Cells, Cultured; Chromones; Culture Media, Conditioned; DNA; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Flavonoids; Hot Temperature; Insulin-Like Growth Factor I; Liver; Male; Mitogens; Mitosis; Molecular Weight; Morpholines; Peptide Fragments; Protein Precursors; Proteins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1	2000
Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer. Cancer research, 2000, Jun-01, Volume: 60, Issue:11 Topics: Cell Cycle; Cell Division; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, ras; Humans; Male; MAP Kinase Signaling System; Oncogene Protein p21(ras); Polymorphism, Single-Stranded Conformational; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad4 Protein; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured	2000
Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor. The Journal of biological chemistry, 2000, Sep-08, Volume: 275, Issue:36 Topics: Cell Line; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Kinetics; Lung; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Protein Serine-Threonine Kinases; Signal Transduction; Transcription Factor AP-1; Transforming Growth Factor beta	2000
Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes. Biochemical and biophysical research communications, 2000, Jul-05, Volume: 273, Issue:2 Topics: Animals; Base Sequence; Cell Line, Transformed; Cell Movement; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, ras; Keratinocytes; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Oligonucleotides, Antisense; ras Proteins; Signal Transduction; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator	2000
Association of decreased phosphorylation of ERK-2 with costimulation of rat T cell activation by MEK-1 inhibitors and TGF-beta1. Immunology letters, 2000, Jun-01, Volume: 72, Issue:3 Topics: Animals; Butadienes; Cell Line; Cells, Cultured; Cricetinae; Down-Regulation; Enterotoxins; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Lymphocyte Activation; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Inbred WF; T-Lymphocytes; Transforming Growth Factor beta	2000
Developmental regulation of neuronal KCa channels by TGFbeta 1: transcriptional and posttranscriptional effects mediated by Erk MAP kinase. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-01, Volume: 20, Issue:15 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Ganglia, Parasympathetic; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Mitogen-Activated Protein Kinases; Neurons; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta	2000
Requirement of hydrogen peroxide generation in TGF-beta 1 signal transduction in human lung fibroblast cells: involvement of hydrogen peroxide and Ca2+ in TGF-beta 1-induced IL-6 expression. Journal of immunology (Baltimore, Md. : 1950), 2000, Aug-15, Volume: 165, Issue:4 Topics: Calcium; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Hydrogen Peroxide; Interleukin-6; Intracellular Fluid; Lung; Mitogen-Activated Protein Kinases; Protein Binding; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transforming Growth Factor beta; Tumor Cells, Cultured	2000
Activation of protein kinase C inhibits the expression of connective tissue growth factor. Biochemical and biophysical research communications, 2000, Aug-28, Volume: 275, Issue:2 Topics: Animals; Connective Tissue Growth Factor; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Growth Substances; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta	2000
Angiotensin II activates collagen I gene through a mechanism involving the MAP/ER kinase pathway. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 36, Issue:3 Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Collagen; Decorin; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix Proteins; Flavonoids; Gene Expression Regulation, Enzymologic; Genes, fos; Genetic Markers; Humans; Imidazoles; Kidney; Luciferases; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proteoglycans; Proto-Oncogene Mas; Pyridines; Tetrazoles; Transcriptional Activation; Transforming Growth Factor beta	2000
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:10 Topics: Adult; Aged; Animals; Animals, Newborn; Biomarkers; Blotting, Northern; Cells, Cultured; Colforsin; Collagen; Connective Tissue Growth Factor; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Female; Fibroblasts; Fibronectins; Fibrosis; Flavonoids; Genes, Reporter; Growth Substances; Heart Diseases; Heart Ventricles; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Luciferases; Male; MAP Kinase Signaling System; Middle Aged; Myocardial Infarction; Myocardium; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tissue Distribution; Transforming Growth Factor beta; Up-Regulation	2000
Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF-beta and MAPK. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:6 Topics: Animals; Aorta; Bradykinin; Collagen; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Expression; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transcriptional Activation; Transforming Growth Factor beta	2000
Extracellular signal-regulated kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells. Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:12 Topics: Animals; Cell Cycle Proteins; Cell Line; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Gene Expression; Glomerular Mesangium; Glucose; Immediate-Early Proteins; Mice; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Transforming Growth Factor beta; Transforming Growth Factor beta1	2000
Transforming growth Factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. American journal of respiratory and critical care medicine, 2001, Volume: 163, Issue:1 Topics: Carbazoles; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lung; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscles; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Pyridines; Transforming Growth Factor beta	2001
Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos. American journal of respiratory cell and molecular biology, 2001, Volume: 24, Issue:4 Topics: Animals; Asbestos, Amosite; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Flavonoids; Gene Expression; Iron; Leupeptins; Male; MAP Kinase Signaling System; NF-kappa B; Platelet-Derived Growth Factor; Procollagen; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Trachea; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha	2001
Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone, 2001, Volume: 28, Issue:5 Topics: Alkaline Phosphatase; Animals; Bone Development; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Cricetinae; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; MAP Kinase Kinase 3; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; RNA, Messenger; Stem Cells; Transforming Growth Factor beta	2001
Pertussis toxin activates tyrosine kinase signaling cascade in myelomonocytic cells: a mechanism for cell adhesion. Biochemical and biophysical research communications, 2001, May-25, Volume: 283, Issue:5 Topics: Cell Adhesion; Chromones; Dimethyl Sulfoxide; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Kinetics; Lipopolysaccharide Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Transforming Growth Factor beta; Tyrphostins; U937 Cells; Virulence Factors, Bordetella	2001
Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells. Experimental hematology, 2001, Volume: 29, Issue:5 Topics: Cell Differentiation; Cell Division; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Flavonoids; Humans; Janus Kinase 2; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; MAP Kinase Signaling System; Megakaryocytes; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Neoplastic Stem Cells; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; STAT3 Transcription Factor; STAT5 Transcription Factor; Thrombopoietin; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Vanadates	2001
Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway. The Journal of biological chemistry, 2001, Aug-03, Volume: 276, Issue:31 Topics: Apoptosis; bcl-2-Associated X Protein; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Caspases; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Cytochrome c Group; Cytosol; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Etoposide; Flavonoids; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Infant, Newborn; Isoquinolines; Mitochondria; Mitogen-Activated Protein Kinases; Naphthalenes; Neoplasm Proteins; Osteoblasts; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Signal Transduction; Skull; Smad Proteins; Smad1 Protein; Sulfonamides; Trans-Activators; Transcription Factors; Transforming Growth Factor beta	2001
Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells. American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:1 Topics: Adenoviridae; Animals; Cholecystokinin; Cycloheximide; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Immunoblotting; In Vitro Techniques; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Protein Binding; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; ras Proteins; Rats; Rats, Wistar; Smad4 Protein; Trans-Activators; Transcription Factor AP-1; Transforming Growth Factor beta	2001
TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS. Leukemia, 2001, Volume: 15, Issue:6 Topics: Acute Disease; Adult; Antigens, CD34; Cell Division; Disease Progression; DNA Replication; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Inhibitors; Flavonoids; Hematopoietic Stem Cells; Humans; Interleukin-3; Janus Kinase 2; Leukemia, Myeloid; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Myelodysplastic Syndromes; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; Smad2 Protein; Thrombopoietin; Thymidine; Trans-Activators; Transforming Growth Factor beta; Tyrphostins	2001
Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation. The Journal of biological chemistry, 2001, Sep-07, Volume: 276, Issue:36 Topics: Active Transport, Cell Nucleus; Blotting, Northern; Butadienes; Cell Division; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique, Indirect; Furin; Humans; Immunoblotting; Luciferases; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nitriles; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Smad Proteins; Smad7 Protein; Subtilisins; Trans-Activators; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1	2001
Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. Journal of neurochemistry, 2001, Volume: 78, Issue:3 Topics: Amino Acids; Animals; Astrocytes; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chromones; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Glycine; Immunoblotting; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Transforming Growth Factor beta; Transforming Growth Factor beta1	2001
Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells. Journal of cellular biochemistry, 2001, Volume: 82, Issue:4 Topics: Animals; Aorta; Butadienes; Cell Line; Dose-Response Relationship, Drug; Endothelial Growth Factors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Epidermal growth factor induces expression of decay-accelerating factor in human colonic cancer cells via the mitogen-activated protein kinase pathway. The Journal of laboratory and clinical medicine, 2001, Volume: 138, Issue:3 Topics: Blotting, Northern; CD55 Antigens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Flavonoids; HT29 Cells; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Platelet-Derived Growth Factor; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta	2001
Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins. Brain research. Developmental brain research, 2001, Sep-23, Volume: 130, Issue:1 Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Corpus Striatum; Dopamine; Enzyme Inhibitors; Female; Fetus; Flavonoids; Immunohistochemistry; Mice; Neurons; Phenotype; Pregnancy; Transforming Growth Factor beta; Tyrosine 3-Monooxygenase	2001
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling. Molecular and cellular biology, 2001, Volume: 21, Issue:21 Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin	2001
Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors. Journal of cell science, 2001, Volume: 114, Issue:Pt 18 Topics: Actins; Animals; Azepines; Carrier Proteins; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Fibronectins; Flavonoids; Focal Adhesions; Humans; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Polymers; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Rats; Transforming Growth Factor beta	2001
Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatology (Baltimore, Md.), 2001, Volume: 34, Issue:5 Topics: Animals; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Flavonoids; Immunologic Techniques; Liver; Male; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation	2001
Stimulatory effect of zinc on deoxyribonucleic acid synthesis in bone growth of newborn rats: enhancement with zinc and insulin-like growth factor-I. Calcified tissue international, 2001, Volume: 69, Issue:3 Topics: Age Factors; Animals; Animals, Newborn; Bone Development; Cells, Cultured; Diaphyses; DNA; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Female; Femur; Flavonoids; Insulin-Like Growth Factor I; Male; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; Picolinic Acids; Rats; Rats, Wistar; Staurosporine; Transforming Growth Factor beta; Zinc Sulfate	2001
Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney. Development (Cambridge, England), 2001, Volume: 128, Issue:21 Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; DNA-Binding Proteins; Drosophila Proteins; Enzyme Inhibitors; Female; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glycosaminoglycans; Kidney; MAP Kinase Signaling System; Mesoderm; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morphogenesis; Nerve Growth Factors; Nerve Tissue Proteins; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Repressor Proteins; Transforming Growth Factor beta; Ureter	2001
Cardioprotective effects of transforming growth factor-beta1 during early reoxygenation or reperfusion are mediated by p42/p44 MAPK. Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:6 Topics: Animals; Animals, Newborn; Apoptosis; Cell Hypoxia; Cells, Cultured; Enzyme Inhibitors; Flavonoids; In Situ Nick-End Labeling; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1	2001
Angiotensin II via activation of type 1 receptor upregulates expression of endoglin in human coronary artery endothelial cells. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antigens, CD; Cells, Cultured; Coronary Vessels; Endoglin; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Losartan; Mitogen-Activated Protein Kinases; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Vascular Cell Adhesion Molecule-1	2001
Involvement of MAP kinase cascades in Smad7 transcriptional regulation. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: Animals; Anisomycin; Base Sequence; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Pyridines; Rats; RNA, Messenger; Smad7 Protein; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta	2001
TGF-beta1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion. Journal of cell science, 2001, Volume: 114, Issue:Pt 21 Topics: Cell Adhesion; Cell Line; Enzyme Inhibitors; Fibronectins; Flavonoids; Gene Expression; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Plasminogen Activator Inhibitor 1; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vitronectin	2001
Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. The Journal of biological chemistry, 2002, Mar-08, Volume: 277, Issue:10 Topics: Antigens, CD34; Apoptosis; Catalytic Domain; Cell Cycle; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hematopoiesis; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Interferon-beta; Interferons; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Signal Transduction; Stem Cells; Time Factors; Transforming Growth Factor beta; Up-Regulation	2002
Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2002, Volume: 17, Issue:2 Topics: Activin Receptors, Type I; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Collagen; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; ras Proteins; Receptor, Transforming Growth Factor-beta Type I; Receptors, Collagen; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Smad1 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta	2002
Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases. Biochimica et biophysica acta, 2002, Feb-13, Volume: 1589, Issue:1 Topics: Animals; Blotting, Northern; Cell Line; Enzyme Activation; Flavonoids; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tretinoin; Up-Regulation	2002
IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta. Journal of immunology (Baltimore, Md. : 1950), 2002, Apr-15, Volume: 168, Issue:8 Topics: Adjuvants, Immunologic; Antibodies, Blocking; Antibodies, Monoclonal; Cell Membrane; Down-Regulation; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interferon-gamma; Interleukin-10; Interleukin-9; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophage Activation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Receptors, Interleukin; Receptors, Interleukin-9; Respiratory Burst; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha	2002
Characterization of the increase in bone 66 kDa protein component with healing rat fractures: stimulatory effect of zinc. International journal of molecular medicine, 2002, Volume: 9, Issue:5 Topics: Animals; Bone and Bones; Cycloheximide; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Estradiol; Flavonoids; Fracture Healing; Fractures, Bone; Insulin-Like Growth Factor I; Male; Parathyroid Hormone; Phosphoproteins; Rats; Rats, Wistar; Staurosporine; Time Factors; Transforming Growth Factor beta; Zinc	2002
Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. The Journal of biological chemistry, 2002, Sep-27, Volume: 277, Issue:39 Topics: Alkaline Phosphatase; Animals; Blotting, Western; Butadienes; Culture Media, Serum-Free; Curcumin; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Dominant; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; Phosphorylation; Protein Structure, Tertiary; RNA, Messenger; Signal Transduction; Smad3 Protein; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta	2002
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:2 Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Blotting, Western; Cell Division; Collagen Type I; Cyclic AMP Response Element-Binding Protein; Drug Synergism; Female; Fibroblasts; Fibronectins; Fibrosis; Flavonoids; Humans; Imidazoles; Luciferases; Myocardium; Nifedipine; Norepinephrine; Phosphorylation; Plasminogen Activator Inhibitor 1; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured	2002
Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes. Biochemical and biophysical research communications, 2002, Aug-16, Volume: 296, Issue:2 Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Curcumin; Dipeptides; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Humans; Imidazoles; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Oligodeoxyribonucleotides, Antisense; Promoter Regions, Genetic; Pyridines; ras Proteins; Recombinant Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured	2002
Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion. Journal of neurophysiology, 2002, Volume: 88, Issue:2 Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Animals; Cell Culture Techniques; Chick Embryo; Chromones; Electrophysiology; Enzyme Inhibitors; Flavonoids; Immunoblotting; Immunohistochemistry; Large-Conductance Calcium-Activated Potassium Channels; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channels, Calcium-Activated; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transforming Growth Factor beta; Wortmannin	2002
Differential, tissue-specific, transcriptional regulation of apolipoprotein B secretion by transforming growth factor beta. The Journal of biological chemistry, 2002, Oct-18, Volume: 277, Issue:42 Topics: Amino Acid Motifs; Apolipoproteins B; Blotting, Northern; Caco-2 Cells; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Plasmids; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Smad3 Protein; Smad4 Protein; Time Factors; Tissue Distribution; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Transgenes; Tumor Cells, Cultured	2002
Dietary salt intake activates MAP kinases in the rat kidney. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:12 Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Kidney; Kidney Glomerulus; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Sodium Chloride, Dietary; Tetraethylammonium; Transforming Growth Factor beta; Transforming Growth Factor beta1	2002
Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2002, Volume: 17, Issue:10 Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cell Line; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Genes, Dominant; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mesoderm; Mice; Minerals; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Pluripotent Stem Cells; Protein Serine-Threonine Kinases; Rats; Recombinant Fusion Proteins; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta	2002
Bone morphogenetic protein signaling in articular chondrocyte differentiation. Biochemical and biophysical research communications, 2003, Feb-07, Volume: 301, Issue:2 Topics: Activin Receptors, Type I; Activin Receptors, Type II; Adenoviridae; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cartilage, Articular; Cattle; Cell Differentiation; Cells, Cultured; Chondrocytes; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Protein Serine-Threonine Kinases; Proteins; Pyridines; Receptors, Growth Factor; Signal Transduction; Smad Proteins; Smad1 Protein; Smad5 Protein; Smad6 Protein; Trans-Activators; Transforming Growth Factor beta; Tretinoin	2003
Effects of transforming growth factor-[beta] and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells. American journal of respiratory cell and molecular biology, 2003, Volume: 29, Issue:1 Topics: Administration, Topical; Anthracenes; Anti-Inflammatory Agents; Apoptosis; Bronchi; Budesonide; Caspase 3; Caspases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Glucocorticoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Transforming Growth Factor beta	2003
Progression of chondrogenesis in C3H10T1/2 cells is associated with prolonged and tight regulation of ERK1/2. Journal of cellular biochemistry, 2003, Apr-15, Volume: 88, Issue:6 Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line; Chondrogenesis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Serum Response Factor; Signal Transduction; Time Factors; Transcription Factor AP-1; Transforming Growth Factor beta	2003
Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells. Journal of cellular biochemistry, 2003, Apr-15, Volume: 88, Issue:6 Topics: Alkaline Phosphatase; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Chromones; Enzyme Induction; Enzyme Inhibitors; Fetus; Flavonoids; Insulin-Like Growth Factor I; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Skull; Transforming Growth Factor beta	2003
Air pollution particles produce airway wall remodeling in rat tracheal explants. American journal of respiratory cell and molecular biology, 2003, Volume: 29, Issue:3 Pt 1 Topics: Air Pollution; alpha-Fetoproteins; Animals; Cells, Cultured; Chelating Agents; Collagen; Deferoxamine; DNA, Complementary; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Expression Regulation; Hydroxyproline; Imidazoles; Iron; Mitogen-Activated Protein Kinases; NF-kappa B; Organ Culture Techniques; Oxidants; p38 Mitogen-Activated Protein Kinases; Peptides; Procollagen; Promoter Regions, Genetic; Pyridines; Rats; Thiourea; Time Factors; Trachea; Transforming Growth Factor beta; Transforming Growth Factor beta1	2003
Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. Arteriosclerosis, thrombosis, and vascular biology, 2003, Jun-01, Volume: 23, Issue:6 Topics: Androstadienes; Animals; Antioxidants; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Platelet-Derived Growth Factor; Polyphenols; Protein Processing, Post-Translational; Pyridines; Rats; Reactive Oxygen Species; RNA, Messenger; Thrombin; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Wine; Wortmannin	2003
Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells. The Journal of laboratory and clinical medicine, 2003, Volume: 141, Issue:4 Topics: Animals; Antioxidants; Cell Line; Culture Media, Conditioned; Enzyme Inhibitors; Flavonoids; Glycated Serum Albumin; Glycation End Products, Advanced; Glycosylation; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidative Stress; Serum Albumin; Thiobarbituric Acid Reactive Substances; Thioctic Acid; Transforming Growth Factor beta; Transforming Growth Factor beta1	2003
TGF-beta1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production. Cell death and differentiation, 2003, Volume: 10, Issue:5 Topics: 3T3 Cells; Animals; Apoptosis; Cell Division; Ceramides; Culture Media; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Time Factors; Transforming Growth Factor beta	2003
Regulation of IL-11 expression in intestinal myofibroblasts: role of c-Jun AP-1- and MAPK-dependent pathways. American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:3 Topics: Adenoviridae; Cells, Cultured; Colon; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Transfer Techniques; Genetic Vectors; Humans; Interleukin-1; Interleukin-11; Kinetics; Mitogen-Activated Protein Kinases; Muscle, Smooth; Proto-Oncogene Proteins c-jun; Transcription Factor AP-1; Transforming Growth Factor beta; Transforming Growth Factor beta1	2003
Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts. Archives of biochemistry and biophysics, 2003, Jul-01, Volume: 415, Issue:1 Topics: 3T3 Cells; Angiogenesis Inducing Agents; Animals; Butadienes; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Growth Factors; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; Pyridines; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
TGFbeta1 signaling via alphaVbeta6 integrin. Molecular cancer, 2003, Aug-07, Volume: 2 Topics: Antigens, Neoplasm; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Division; Cell Line; Cell Line, Tumor; Cytoskeleton; DNA-Binding Proteins; Fibronectins; Flavonoids; HeLa Cells; Humans; Integrins; Microscopy, Confocal; Phosphorylation; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad4 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine	2003
Cyclic AMP inhibits TGFbeta1-induced cell-scattering and invasiveness in murine-transformed keratinocytes. International journal of cancer, 2003, Dec-10, Volume: 107, Issue:5 Topics: Animals; Cell Line, Transformed; Cell Movement; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Keratinocytes; Matrix Metalloproteinase 9; Mice; Neoplasm Invasiveness; Recombinant Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1; Urokinase-Type Plasminogen Activator	2003
Activation of P2X7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2. Cellular signalling, 2003, Volume: 15, Issue:12 Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Astrocytes; Blotting, Northern; Blotting, Western; Brain; Carbazoles; Cell Line; Dose-Response Relationship, Drug; Flavonoids; Gene Expression; Indoles; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1	2003
B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation. Circulation research, 2004, Mar-05, Volume: 94, Issue:4 Topics: Adolescent; Blotting, Western; Butadienes; Cell Division; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Humans; Inflammation; Male; MAP Kinase Signaling System; Middle Aged; Muscle Proteins; Natriuretic Peptide, Brain; Nitriles; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta; Ventricular Remodeling	2004
Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase. Oncogene, 2004, Mar-04, Volume: 23, Issue:9 Topics: Actins; Animals; beta Catenin; Biomarkers; Cadherins; Cell Differentiation; Cell Line; Cell Nucleus; Cell Size; Cytoskeletal Proteins; Cytoskeleton; DNA-Binding Proteins; Dogs; Epithelial Cells; Flavonoids; Gene Expression Regulation; Hepatocyte Growth Factor; Humans; Mesoderm; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Mar-31, Volume: 24, Issue:13 Topics: Active Transport, Cell Nucleus; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Count; Cell Differentiation; Cell Nucleus; Cells, Cultured; Dendrites; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblast Growth Factors; Flavonoids; Genes, Dominant; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Rats; Rats, Sprague-Dawley; Smad Proteins; Smad1 Protein; Sympathetic Nervous System; Synapses; Trans-Activators; Transforming Growth Factor beta	2004
Effect of transforming growth factor-beta on activity of connective tissue growth factor gene promoter in mouse NIH/3T3 fibroblasts. Acta pharmacologica Sinica, 2004, Volume: 25, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Flavonoids; Imidazoles; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Luciferases; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
Differential activation of MAPK signaling pathways by TGF-beta1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis. Stem cells and development, 2004, Volume: 13, Issue:1 Topics: Anisomycin; Antigens, CD34; Bone Marrow Cells; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Hematopoiesis; Humans; Immunoblotting; Leukocytes, Mononuclear; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression. Biochemical and biophysical research communications, 2004, May-21, Volume: 318, Issue:1 Topics: Blotting, Western; Cell Line, Tumor; DNA-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Gene Silencing; Humans; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Protein Biosynthesis; Proteins; Proteome; RNA Interference; Signal Transduction; Smad4 Protein; Trans-Activators; Transforming Growth Factor beta	2004
[Transforming growth factor beta 1 modulates connective tissue growth factor expression via Smad2 signaling pathway in podocyte in vitro]. Zhonghua yi xue za zhi, 2004, Apr-02, Volume: 84, Issue:7 Topics: Angiotensin II; Blotting, Western; Cells, Cultured; Connective Tissue Growth Factor; DNA-Binding Proteins; Flavonoids; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Glomerulus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation. Clinical & experimental metastasis, 2004, Volume: 21, Issue:2 Topics: Binding, Competitive; Cell Line, Tumor; Cell Movement; Collagen; Depression, Chemical; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Laminin; MAP Kinase Signaling System; Membrane Glycoproteins; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Proteoglycans; Structure-Activity Relationship; Transforming Growth Factor beta; Transforming Growth Factor beta1; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitor, Kunitz Soybean; Trypsin Inhibitors; Urokinase-Type Plasminogen Activator	2004
Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells. Journal of cellular biochemistry, 2004, Oct-15, Volume: 93, Issue:3 Topics: DNA-Binding Proteins; Female; Flavonoids; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Ovarian Neoplasms; Plasminogen Activator Inhibitor 1; Protein Kinases; Pyrimidines; Signal Transduction; Smad2 Protein; Smad3 Protein; src-Family Kinases; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator	2004
Lysophosphatidic acid inhibits TGF-beta-mediated stimulation of type I collagen mRNA stability via an ERK-dependent pathway in dermal fibroblasts. Matrix biology : journal of the International Society for Matrix Biology, 2004, Volume: 23, Issue:6 Topics: Blotting, Northern; Cells, Cultured; Collagen; Collagen Type I; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Humans; Immunoprecipitation; Luciferases; Lysophospholipids; Platelet-Derived Growth Factor; RNA; RNA, Messenger; Time Factors; Transfection; Transforming Growth Factor beta	2004
In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling. American journal of physiology. Lung cellular and molecular physiology, 2005, Volume: 288, Issue:3 Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Cycle; Cells, Cultured; Cytoprotection; DNA Damage; DNA Glycosylases; DNA-Binding Proteins; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Hyperoxia; Inosine; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Uric Acid	2005
c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells. Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:2 Topics: Acetophenones; Acetylcysteine; Animals; Catalase; Cell Line; Ditiocarb; DNA-Binding Proteins; Fibroblasts; Flavonoids; Fluoresceins; Gene Expression Regulation; Gene Targeting; Hydrogen Peroxide; Mice; Mice, Inbred C3H; Microfilament Proteins; Muscle Proteins; NADPH Oxidases; Naphthalenes; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyrimidines; Recombinant Fusion Proteins; Serum Response Factor; Signal Transduction; Smad3 Protein; Smad4 Protein; Smad6 Protein; src-Family Kinases; Sulfones; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1	2005
Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. Journal of biochemistry, 2004, Volume: 136, Issue:5 Topics: Carcinoma, Hepatocellular; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; Flavonoids; G1 Phase; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Mitogens; Phosphorylation; S Phase; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. The Journal of biological chemistry, 2005, Mar-18, Volume: 280, Issue:11 Topics: Adenoviridae; Animals; beta-Galactosidase; Blotting, Western; Cells, Cultured; Collagen; Collagen Type I; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Imidazoles; Liver; Male; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Ribonucleases; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Smad Proteins; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta	2005
Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway. American journal of respiratory cell and molecular biology, 2005, Volume: 32, Issue:4 Topics: Animals; Base Sequence; Butadienes; Cells, Cultured; DNA, Complementary; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; Lung; MAP Kinase Signaling System; Mice; Nitriles; Recombinant Proteins; RNA Stability; RNA, Messenger; Swiss 3T3 Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha	2005
SAPK/JNK plays a role in transforming growth factor-beta-induced VEGF synthesis in osteoblasts. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2005, Volume: 37, Issue:3 Topics: 3T3 Cells; Animals; Anthracenes; Enzyme Inhibitors; Flavonoids; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Osteoblasts; Phosphorylation; Skull; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A	2005
TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. Journal of cell science, 2005, Oct-15, Volume: 118, Issue:Pt 20 Topics: Cadherins; Catenins; Cell Adhesion; Cell Aggregation; Cell Line, Tumor; Cell Movement; Chromones; Down-Regulation; Flavonoids; Humans; Morpholines; Multiprotein Complexes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Proto-Oncogene Proteins p21(ras); PTEN Phosphohydrolase; Transforming Growth Factor beta	2005
ERK-dependent signaling pathway and transcriptional factor Ets-1 regulate matrix metalloproteinase-9 production in transforming growth factor-beta1 stimulated glomerular podocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2005, Volume: 16, Issue:4-6 Topics: Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Enzymologic; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mice; Podocytes; Proto-Oncogene Protein c-ets-1; Smad2 Protein; Staurosporine; Transforming Growth Factor beta; Transforming Growth Factor beta1	2005
Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability. The American journal of pathology, 2005, Volume: 167, Issue:6 Topics: Cell Line, Tumor; Claudin-1; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Escherichia coli Infections; Escherichia coli O157; Flavonoids; Gene Expression Regulation; Humans; Interleukin-8; MAP Kinase Signaling System; Membrane Proteins; Tight Junctions; Transforming Growth Factor beta	2005
Effect of biologic mediators on ciprofloxacin accumulation by gingival fibroblasts. Journal of periodontology, 2005, Volume: 76, Issue:12 Topics: Adult; Anti-Infective Agents; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ciprofloxacin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Fluorescence; Gingiva; Humans; Imidazoles; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Up-Regulation	2005
Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells. Neurotoxicity research, 2005, Volume: 8, Issue:3-4 Topics: Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Death; Cells, Cultured; Cerebral Cortex; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ethidium; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; Interleukin-1; Neuroglia; Neurons; Nitrites; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetrazolium Salts; Thiazoles; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1	2005
Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. American journal of physiology. Cell physiology, 2006, Volume: 290, Issue:4 Topics: Animals; Antibodies; Autocrine Communication; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Interleukin-1; Pancreas; Rats; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1	2006
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. The Journal of biological chemistry, 2006, Mar-24, Volume: 281, Issue:12 Topics: Animals; Bronchoalveolar Lavage; Caspases; Cell Death; Collagen; DNA; Early Growth Response Protein 1; Enzyme Inhibitors; Fibrosis; Flavonoids; Immunoblotting; In Situ Nick-End Labeling; Inflammation; Interleukin-13; Lung; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Models, Statistical; RNA; RNA, Messenger; STAT6 Transcription Factor; Th2 Cells; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transgenes	2006
Contribution of Src-FAK signaling to the induction of connective tissue growth factor in renal fibroblasts. Kidney international, 2006, Volume: 69, Issue:8 Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Line, Transformed; Chromones; Colchicine; Collagen Type I; Connective Tissue Growth Factor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Extracellular Matrix; Fibroblasts; Flavonoids; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Humans; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Microscopy, Fluorescence; Models, Biological; Morpholines; Paclitaxel; Phalloidine; Rhodamines; Signal Transduction; src-Family Kinases; Transforming Growth Factor beta; Wortmannin	2006
Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Molecular cancer research : MCR, 2006, Volume: 4, Issue:3 Topics: Cell Movement; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Flavonoids; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Phosphorylation; Sp1 Transcription Factor; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Transforming Growth Factor beta1	2006
Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation. The Journal of surgical research, 2006, Volume: 135, Issue:1 Topics: Adolescent; Adult; Anthracenes; Blood Proteins; Culture Media, Conditioned; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keloid; Keratinocytes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta2; Transforming Growth Factor beta3	2006
Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries. Kidney international, 2006, Volume: 69, Issue:9 Topics: Animals; Cytosol; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Free Radical Scavengers; Gene Expression; Glucose; Glycation End Products, Advanced; Kidney Glomerulus; Male; Mesangial Cells; Oxidative Stress; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-jun; ras Proteins; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Transforming Growth Factor beta	2006
Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells. Journal of cellular biochemistry, 2006, Sep-01, Volume: 99, Issue:1 Topics: Animals; Autocrine Communication; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Interleukin-6; Pancreas; Rats; RNA, Messenger; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1	2006
betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin. Experimental & molecular medicine, 2006, Apr-30, Volume: 38, Issue:2 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chromones; Enzyme Inhibitors; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Integrins; Molecular Sequence Data; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paxillin; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Receptors, Vitronectin; Signal Transduction; src-Family Kinases; Transforming Growth Factor beta	2006
Involvement of p38 MAP kinase and Smad3 in TGF-beta-mediated mast cell functions. Cellular signalling, 2006, Volume: 18, Issue:12 Topics: Animals; Anthracenes; Blotting, Western; Bone Marrow Cells; Cell Movement; Cell Proliferation; Cells, Cultured; Chymases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad3 Protein; Transforming Growth Factor beta; Tryptases; Up-Regulation	2006
Endoglin modulation of TGF-beta1-induced collagen synthesis is dependent on ERK1/2 MAPK activation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2006, Volume: 18, Issue:1-3 Topics: Animals; Antigens, CD; Blotting, Northern; Blotting, Western; Cell Line; Collagen; Endoglin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Pyridines; Rats; Receptors, Cell Surface; RNA, Messenger; Time Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1	2006
ERK contributes to the effects of Smad signaling on oxidized LDL-induced PAI-1 expression in human mesangial cells. Translational research : the journal of laboratory and clinical medicine, 2006, Volume: 148, Issue:4 Topics: Antibodies, Blocking; Benzamides; Butadienes; Cells, Cultured; Dioxoles; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glomerular Mesangium; Humans; Lipoproteins, LDL; Nitriles; Phosphorylation; Plasminogen Activator Inhibitor 1; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta	2006
Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:6 Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Cells, Cultured; Colon; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; GTP-Binding Protein alpha Subunit, Gi2; Imidazoles; Interleukin-11; Interleukin-1beta; Intestine, Small; Methyl Ethers; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta	2007
Abrogation of TGFbeta signaling induces apoptosis through the modulation of MAP kinase pathways in breast cancer cells. Experimental cell research, 2007, May-01, Volume: 313, Issue:8 Topics: Apoptosis; Autocrine Communication; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; Female; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta	2007
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism. The Biochemical journal, 2007, Jul-15, Volume: 405, Issue:2 Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation	2007
Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts. The Journal of biological chemistry, 2007, Jul-20, Volume: 282, Issue:29 Topics: Animals; Atherosclerosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Mice; Nuclear Receptor Subfamily 4, Group A, Member 2; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Parathyroid Hormone; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Signal Transduction; Transcription Factors; Transforming Growth Factor beta	2007
RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis, 2007, Volume: 28, Issue:11 Topics: Blotting, Western; Cell Line; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad4 Protein; Transforming Growth Factor beta	2007
TGF-beta effects on airway smooth muscle cell proliferation, VEGF release and signal transduction pathways. Respirology (Carlton, Vic.), 2009, Volume: 14, Issue:3 Topics: Androstadienes; Anthracenes; Cell Proliferation; Cells, Cultured; Dexamethasone; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glucocorticoids; Humans; Lung; MAP Kinase Kinase 4; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Signal Transduction; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Wortmannin	2009
Role of ERK/mTOR signaling in TGFbeta-modulated focal adhesion kinase mRNA stability and protein synthesis in cultured rat IEC-6 intestinal epithelial cells. Cell and tissue research, 2009, Volume: 336, Issue:2 Topics: Animals; Carrier Proteins; Cells, Cultured; Enterocytes; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesion Kinase 1; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Biosynthesis; Protein Kinases; Protein Stability; Rats; Ribosomal Protein S6 Kinases, 70-kDa; RNA Stability; TOR Serine-Threonine Kinases; Transcription, Genetic; Transforming Growth Factor beta; Wound Healing	2009
Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors. Annals of clinical and laboratory science, 2009,Spring, Volume: 39, Issue:2 Topics: 12E7 Antigen; Antigens, CD; Cell Adhesion Molecules; Cell Line, Tumor; Cell Nucleus; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Profiling; Humans; Neuroectodermal Tumors; NF-kappa B; Phosphorylation; Protein Kinases; Proteome; RNA, Messenger; Sarcoma, Ewing; Signal Transduction; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Up-Regulation	2009
Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs. Journal of immunology (Baltimore, Md. : 1950), 2009, Nov-15, Volume: 183, Issue:10 Topics: Animals; Anthracenes; Bacterial Outer Membrane Proteins; Butadienes; Cell Adhesion Molecules; Cell Survival; Cronobacter sakazakii; Dendritic Cells; Enterobacteriaceae Infections; Enzyme Inhibitors; Epithelial Cells; Flavonoids; HeLa Cells; Humans; Imidazoles; Interleukin-10; Lectins, C-Type; Lipopolysaccharides; Lymphocyte Activation; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase Kinases; Nitriles; Pyridines; Rats; Receptors, Cell Surface; Transfection; Transforming Growth Factor beta	2009
De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:3 Topics: beta Catenin; Blotting, Western; Bronchi; Butadienes; Cell Line; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genes, ras; Glycogen Synthase Kinase 3; Humans; Immunohistochemistry; Immunoprecipitation; Mitogen-Activated Protein Kinase Kinases; Myocytes, Smooth Muscle; Nitriles; Polymerase Chain Reaction; Transforming Growth Factor beta	2010
The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell. Journal of cellular physiology, 2011, Volume: 226, Issue:5 Topics: Animals; beta Catenin; Bone Morphogenetic Protein 2; Cell Line; Cell Proliferation; Cyclin D1; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Intervertebral Disc; Intervertebral Disc Degeneration; Lithium Chloride; Mice; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Smad Proteins, Receptor-Regulated; TCF Transcription Factors; Time Factors; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Wnt Proteins; Wnt3 Protein	2011
Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin-10 through membrane-bound TGF-β. Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:1 Topics: Animals; Apoptosis; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Hepatitis; Immune Tolerance; Interleukin-10; Kupffer Cells; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phagocytosis; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha	2011
Peroxisome proliferator-activated receptor γ (PPARγ) plays a critical role in the development of TGFβ resistance of H460 cell. Cellular signalling, 2011, Volume: 23, Issue:10 Topics: Anilides; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunoprecipitation; Mitogen-Activated Protein Kinases; PPAR gamma; Protein Binding; Pyridines; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Trypan Blue	2011
Up-regulation of TGF-β via the activation of extracellular signal-regulated kinase 1 and 2 induced by prorenin in human renal mesangial cells. Molecular medicine reports, 2012, Volume: 5, Issue:1 Topics: Cells, Cultured; Enzyme Activation; Enzyme Activators; Flavonoids; Humans; Mesangial Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligopeptides; Phosphorylation; Prorenin Receptor; Receptors, Cell Surface; Recombinant Proteins; Renin; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Up-Regulation	2012
Growth factor regulation of intracellular pH homeostasis under hypoxic conditions in isolated equine articular chondrocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2013, Volume: 31, Issue:2 Topics: Acid-Base Equilibrium; Androstadienes; Animals; Cartilage, Articular; Chondrocytes; Flavonoids; Homeostasis; Horses; Hydrogen-Ion Concentration; Hypoxia; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Oxygen; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Reactive Oxygen Species; Transforming Growth Factor beta; Wortmannin	2013
MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:5 Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Flavonoids; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1; Rats; Smad Proteins; Transforming Growth Factor beta	2015
Pterocarpus santalinus L. Regulated Ultraviolet B Irradiation-induced Procollagen Reduction and Matrix Metalloproteinases Expression Through Activation of TGF-β/Smad and Inhibition of the MAPK/AP-1 Pathway in Normal Human Dermal Fibroblasts. Photochemistry and photobiology, 2018, Volume: 94, Issue:1 Topics: Anthracenes; Fibroblasts; Flavonoids; Humans; Interleukin-6; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Phosphorylation; Plant Extracts; Procollagen; Pterocarpus; Skin; Skin Aging; Transcription Factor AP-1; Transforming Growth Factor beta; Ultraviolet Rays	2018
Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis. Cancer cell, 2019, 01-14, Volume: 35, Issue:1 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Transdifferentiation; Epithelial-Mesenchymal Transition; Female; Flavonoids; Humans; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Proto-Oncogene Proteins c-met; Rosiglitazone; Signal Transduction; Transforming Growth Factor beta	2019