pd 98059 has been researched along with thymidine in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (26.09) | 18.2507 |
| 2000's | 32 (69.57) | 29.6817 |
| 2010's | 2 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bridges, AJ; Decker, SJ; Dudley, DT; Pang, L; Saltiel, AR | 1 |
| Boarder, MR; Morton, C; Ng, LL; Wilkie, N | 1 |
| Freissmuth, M; Gloria-Maercker, E; Höller, C; Mancusi, G; Schütz, W; Sexl, V | 1 |
| Benter, IF; Karzoun, NA; Malik, KU; Muthalif, MM; Uddin, MR | 1 |
| Borodinsky, LN; Fiszman, ML | 1 |
| Bushman, TL; Kuemmerle, JF | 1 |
| Kokkonen, GC; Luo, Y; Neve, KA; Roth, GS; Wang, X | 1 |
| Auer, KL; Dent, P; Fisher, PB; Gao, B; Kunos, G; Seth, P; Spector, MS; Tombes, RM | 1 |
| Bulleit, RF; Cui, H; Meng, Y | 1 |
| Funder, JW; Kawashima, S; Li, H; Liu, JP; Robinson, PJ | 1 |
| Ikeda, K; Kawada, N; Kuroki, T; Seki, S | 1 |
| Chambard, JC; Pouysségur, J; Viñals, F | 1 |
| Ikeda, U; Maeda, Y; Mano, H; Okada, K; Oya, Ki; Ozawa, K; Saito, T; Shimada, K; Shimpo, M; Ueno, S | 1 |
| Argenzio, RA; Blikslager, AT; Brenner, DA; Chen, W; Gatzy, J; Graves, LM; Licato, LL; Rhoads, JM; Smith, J | 1 |
| Brunskill, NJ; Dixon, R | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Luo, SF; Wang, CC; Yang, CM | 1 |
| Eischeid, A; Jeng, MH; Santen, RJ; Wang, JP; Yue, W | 1 |
| Aso, T; Kubota, T; Morita, I; Murota, S; Taniguchi, Y | 1 |
| Ekokoski, E; Simon, J; Törnquist, K; Webb, TE | 1 |
| Milasincic, DJ; Pilch, PF; Tortorella, LL | 1 |
| Cheng, SL; Huang, Z; Slatopolsky, E | 1 |
| Aiach, M; Brohard, B; Estebanell, E; Lafay, M; Olivot, JM; Rendu, F | 1 |
| Ballas, K; Hoelzer, D; Hofmann, WK; Kalina, U; Koschmieder, S; Kunert, J; Ottmann, OG; Seipelt, G; Wagner, S | 1 |
| Hussain, T; Lokhandwala, MF; Narkar, VA; Pedemonte, C | 1 |
| Baldetorp, B; Edvinsson, L; Erlinge, D; Harden, TK; Hou, M; Kuhn, CM; Lazarowski, E; Möller, S; Pendergast, W | 1 |
| Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE | 1 |
| Hashimoto, N; Kawanabe, Y; Masaki, T | 1 |
| Choo, HH; Dawe, GS; Tsang, F; Wong, WS | 1 |
| Morishita, M; Shimazu, A | 1 |
| Baylink, DJ; Kapur, S; Lau, KH | 1 |
| Amin, AR; Biswas, MH; Hamaguchi, M; Huang, P; Ichigotani, Y; Mon, NN; Oo, ML; Yuan, H | 1 |
| Hama, K; Hanatsuka, K; Kita, H; Mashima, H; Ohashi, A; Ohnishi, H; Satoh, Y; Sugano, K; Tamada, K; Ueda, N; Yasuda, H | 1 |
| Fujimoto, J; Kotani, M; Motegi, A; Sakuraba, H; Yamamoto, T | 1 |
| Fischer, MB; Gruber, R; Kandler, B; Watzek, G | 1 |
| Chang, YL; Guh, JH; Kuo, SC; Lee, FY; Liu, YN; Pan, SL; Peng, CY; Teng, CM | 1 |
| Abad, M; Baniahmad, A; Goeman, F; Palmero, I; Schmidt, O; Serrano, M; Thormeyer, D | 1 |
| Mitev, VI; Praskova, MD; Tencheva, ZS; Velichkova, AA | 1 |
| Li, A; Liu, Q; Wang, X; Ye, J; Zhou, J | 1 |
| Bantekas, C; Kaloyianni, M; Koliakos, G; Konstantinidis, D; Liakos, P; Trachana, V; Vafia, K | 1 |
| Jeong, SY; Kang, SW; Kee, SH; Kim, BM; Kim, YH; Min, BH; Park, IS; Park, JJ; Shim, YJ; Shin, YJ | 1 |
| Bahulayan, A; Holz, O; Matthiesen, S; Racké, K | 1 |
| Griffith, L; Iyer, AK; Tran, KT; Wells, A | 1 |
| Del Monte, MA; Kothary, PC | 1 |
| Choi, WS; Kim, WJ; Lee, EJ; Moon, GS; Moon, SK | 1 |
| Alves, T; Anderluh, G; Borges, HL; Gabilan, NH; Moura-Neto, V; Soletti, RC; Terenzi, H; Vernal, J | 1 |
| Behar, J; Cao, W; Li, D; Resnick, MB; Wands, J; Zhou, X | 1 |
46 other study(ies) available for pd 98059 and thymidine
| Article | Year |
|---|---|
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Topics: 3T3 Cells; Alanine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glutathione Transferase; Humans; Kinetics; Lysine; Mice; Microtubule-Associated Proteins; Mutagenesis, Site-Directed; Point Mutation; Recombinant Fusion Proteins; Thymidine; Tumor Cells, Cultured | 1995 |
Stimulated mitogen-activated protein kinase is necessary but not sufficient for the mitogenic response to angiotensin II. A role for phospholipase D.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipase D; Protein-Tyrosine Kinases; Rats; Thymidine | 1996 |
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Flavonoids; GTP-Binding Proteins; Humans; Isoproterenol; Phosphorylation; Receptors, Purinergic P1; Thymidine; Tyrosine; Vasodilator Agents | 1997 |
Cytochrome P-450 metabolites mediate norepinephrine-induced mitogenic signaling.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Aorta; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Cytochrome P-450 Enzyme System; DNA; Enzyme Inhibitors; Fatty Acids, Unsaturated; Flavanones; Flavonoids; Indomethacin; Lipoxygenase; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Signal Transduction; Thymidine | 1998 |
Extracellular potassium concentration regulates proliferation of immature cerebellar granule cells.
Topics: Animals; Calcium Channel Blockers; Cell Division; Cellular Senescence; Cerebellum; Enzyme Inhibitors; Extracellular Space; Flavonoids; Magnesium Chloride; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Neurons; Nifedipine; omega-Conotoxin GVIA; Osmolar Concentration; Peptides; Potassium; Potassium Chloride; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Thymidine | 1998 |
IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; Jejunum; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Thymidine; Time Factors | 1998 |
D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and Ras-involved ERK and SAP/JNK pathways in rat C6-D2L glioma cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dopamine; Enzyme Activation; Flavonoids; GTP-Binding Proteins; GTPase-Activating Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mitosis; Mutation; Pertussis Toxin; Proteins; ras GTPase-Activating Proteins; ras Proteins; Rats; Receptors, Dopamine D2; Recombinant Proteins; Thymidine; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Carcinoma, Hepatocellular; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Epinephrine; Flavonoids; Humans; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Norepinephrine; Phenylephrine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Thymidine; Transfection; Tumor Cells, Cultured | 1998 |
Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells.
Topics: Animals; Antimanic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Cerebellum; Chromones; Diphosphonates; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin-Like Growth Factor I; Lithium Chloride; Mice; Mice, Inbred Strains; Mitogens; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Stem Cells; Thymidine; Tritium | 1998 |
Differential regulation of MAP kinase activity by corticotropin-releasing hormone in normal and neoplastic corticotropes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; DNA Replication; Enzyme Inhibitors; Flavonoids; Isoquinolines; Mice; Pituitary Gland, Anterior; Pituitary Neoplasms; Sheep; Sulfonamides; Thymidine | 1998 |
Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; Bucladesine; Cell Cycle; Cell Division; Cells, Cultured; Chromones; Cyclin D1; Cyclin D2; Cyclin E; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Inhibitors; Flavonoids; G1 Phase; Imidazoles; Liver; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; S Phase; Thymidine; Tritium | 1999 |
p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; DNA Replication; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; G1 Phase; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Biosynthesis; Ribosomal Protein S6 Kinases; Sirolimus; Thymidine | 1999 |
Endogenously generated nitric oxide by nitric-oxide synthase gene transfer inhibits cellular proliferation.
Topics: Calcium; Cell Division; Cells, Cultured; Embryo, Mammalian; Endothelin-1; Endothelium; Enzyme Inhibitors; Flavonoids; Fura-2; Humans; In Vitro Techniques; Kidney; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphates; Proto-Oncogene Proteins c-fos; Receptors, Endothelin; Thymidine; Transfection | 2000 |
Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism.
Topics: Cell Division; Cell Line; Cyclic AMP; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glutamine; Intestinal Mucosa; Intestines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Oxygen Consumption; Thionucleotides; Thymidine | 2000 |
Albumin stimulates p44/p42 extracellular-signal-regulated mitogen-activated protein kinase in opossum kidney proximal tubular cells.
Topics: Animals; Cell Count; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Kidney Tubules, Proximal; Mannitol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Opossums; Ovalbumin; Recombinant Proteins; Serum Albumin; Thymidine | 2000 |
Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells.
Topics: Animals; Benzoquinones; Bridged-Ring Compounds; Calcium; Cell Division; Chelating Agents; DNA; Dogs; Egtazic Acid; Enzyme Activation; Estrenes; Female; Flavonoids; Interleukin-1; Isoenzymes; Lactams, Macrocyclic; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; Norbornanes; Pertussis Toxin; Phosphorylation; Protein Kinase C; Pyrrolidinones; Quinones; Rifabutin; Thiocarbamates; Thiones; Thymidine; Trachea; Tritium; Tumor Necrosis Factor-alpha; Type C Phospholipases; Virulence Factors, Bordetella | 2000 |
Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Flavonoids; Fulvestrant; Humans; MAP Kinase Signaling System; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Thymidine; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation | 2000 |
Human uterine myometrial smooth muscle cell proliferation and vascular endothelial growth-factor production in response to platelet-derived growth factor.
Topics: Adult; Analysis of Variance; Biological Assay; Blotting, Western; Cell Division; Cells, Cultured; Endothelial Growth Factors; Enzyme Inhibitors; Extracellular Matrix Proteins; Female; Flavonoids; Humans; Indoles; Lymphokines; Maleimides; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth; Myometrium; Platelet-Derived Growth Factor; Protein Isoforms; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thymidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Mechanisms of P2 receptor-evoked DNA synthesis in thyroid FRTL-5 cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; DNA; DNA Primers; DNA Replication; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, Immediate-Early; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Receptors, Purinergic P2; Thymidine; Thyroid Gland; Transcription, Genetic; Tritium; Uridine Diphosphate; Uridine Triphosphate | 2001 |
Critical proliferation-independent window for basic fibroblast growth factor repression of myogenesis via the p42/p44 MAPK signaling pathway.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Division; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Flow Cytometry; Mice; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscles; MyoD Protein; Myogenin; Signal Transduction; Thymidine; Time Factors; Transcription, Genetic | 2001 |
Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation.
Topics: 3T3 Cells; Animals; Calcium; Cations, Divalent; Cell Division; Cell Line; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Kinetics; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neomycin; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Rats; Thymidine | 2001 |
Thrombomodulin prolongs thrombin-induced extracellular signal-regulated kinase phosphorylation and nuclear retention in endothelial cells.
Topics: Active Transport, Cell Nucleus; Antibodies, Monoclonal; Catalysis; Cell Nucleus; Cells, Cultured; DNA; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Proteins; Receptors, Thrombin; Signal Transduction; Thrombin; Thrombomodulin; Thymidine | 2001 |
TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.
Topics: Acute Disease; Adult; Antigens, CD34; Cell Division; Disease Progression; DNA Replication; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Inhibitors; Flavonoids; Hematopoietic Stem Cells; Humans; Interleukin-3; Janus Kinase 2; Leukemia, Myeloid; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Myelodysplastic Syndromes; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; Smad2 Protein; Thrombopoietin; Thymidine; Trans-Activators; Transforming Growth Factor beta; Tyrphostins | 2001 |
Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells.
Topics: Animals; Binding Sites; Cell Line; Cyclic AMP; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; Kidney; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitosis; Opossums; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Dopamine D2; Thymidine | 2001 |
UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
Topics: Animals; Aorta; Cell Survival; Cells, Cultured; Cyclic AMP; DNA; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Growth Substances; Inositol Phosphates; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Protein Kinases; Purinergic P2 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thymidine; Tritium; Type C Phospholipases; Uridine Diphosphate; Uridine Triphosphate | 2002 |
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Histamine; Histamine H1 Antagonists; Humans; Inositol Phosphates; Protein Kinase C; Pyrilamine; Receptors, Histamine H1; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Type C Phospholipases | 2001 |
Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells.
Topics: Acetamides; Animals; Brain Neoplasms; Calcium; Calcium Channel Blockers; Calcium Channels; DNA; Drug Interactions; Endothelin-1; Enzyme Inhibitors; Flavonoids; Glioma; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Rats; Thymidine; Tritium; Tumor Cells, Cultured | 2002 |
Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Chromones; Cyclin D1; DNA Replication; Enzyme Inhibitors; Flavonoids; Guinea Pigs; Male; MAP Kinase Signaling System; Morpholines; Muscle, Smooth; Protein-Tyrosine Kinases; Respiratory Physiological Phenomena; Thrombin; Thymidine | 2002 |
Basic fibroblast growth factor induces the expression of matrix metalloproteinase-3 in human periodontal ligament cells through the MEK2 mitogen-activated protein kinase pathway.
Topics: Analysis of Variance; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase 2; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Periodontal Ligament; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proteoglycans; RNA, Messenger; Thymidine; Time Factors; Up-Regulation | 2003 |
Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways.
Topics: Alkaline Phosphatase; Butadienes; Cell Differentiation; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; Humans; Indomethacin; Integrin beta1; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Osteoblasts; Pertussis Toxin; Phosphorylation; Prostaglandins; Protein Serine-Threonine Kinases; Signal Transduction; Stress, Mechanical; Thymidine; Tritium | 2003 |
The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation.
Topics: Animals; Antigens, Differentiation; BALB 3T3 Cells; Cell Division; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Glycoproteins; Immunoblotting; Indoles; Interleukin-1; Maleimides; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Neural Cell Adhesion Molecule L1; Phospholipase C gamma; Phosphorylation; Plasmids; Precipitin Tests; Protein Kinase C; Pyrrolidinones; Receptors, Immunologic; Signal Transduction; Tetrazolium Salts; Thiazoles; Thymidine; Time Factors; Type C Phospholipases | 2003 |
Angiotensin II stimulates DNA synthesis of rat pancreatic stellate cells by activating ERK through EGF receptor transactivation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blotting, Western; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Losartan; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Pancreas; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Thymidine; Transcriptional Activation; Tritium | 2004 |
ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Topics: Adaptor Proteins, Signal Transducing; Anaplastic Lymphoma Kinase; Animals; Antibodies, Monoclonal; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Immunoblotting; Immunoprecipitation; Insulin Receptor Substrate Proteins; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogens; Neuroblastoma; Neurons; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Thymidine; Time Factors; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
Platelet-released supernatant increases matrix metalloproteinase-2 production, migration, proliferation, and tube formation of human umbilical vascular endothelial cells.
Topics: Basement Membrane; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinases; Capillaries; Cell Extracts; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Matrix Metalloproteinase 2; Platelet Activation; Secretory Vesicles; Thymidine | 2004 |
The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Arteriosclerosis; Blotting, Western; Catheterization; Cell Proliferation; Cells, Cultured; Coronary Restenosis; Dose-Response Relationship, Drug; Flavonoids; Immunohistochemistry; Indazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Chemical; Muscle, Smooth, Vascular; Peptides; Phosphorylation; Protein Kinase Inhibitors; ras Proteins; Rats; Rats, Wistar; Receptor, PAR-1; Signal Transduction; Thrombin; Thymidine | 2004 |
Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.
Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Line; Chickens; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Deletion; Gene Silencing; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Imidazoles; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Mice; NIH 3T3 Cells; Nuclear Proteins; Plasmids; Protein Structure, Tertiary; Proteins; Pyridines; ras Proteins; Retroviridae; Signal Transduction; Thymidine; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2005 |
delta-Opioid agonist induced regulation of E2F1 DNA binding activity in NG108-15 cells.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Electrophoretic Mobility Shift Assay; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Imidazoles; Mice; Neuroblastoma; Protein Binding; Pyridines; Receptors, Opioid, delta; Thymidine; Transcription Factors; Tritium | 2005 |
Inhibition of mitogen-activated protein kinase kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Butadienes; Cell Survival; DNA; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; Humans; Imidazoles; MAP Kinase Kinase 1; Nitriles; Oxides; p38 Mitogen-Activated Protein Kinases; Pyridines; Thymidine; Tissue Culture Techniques; Tumor Cells, Cultured | 2005 |
Inhibition of the Na+-H+ exchanger isoform-1 and the extracellular signal-regulated kinase induces apoptosis: a time course of events.
Topics: Annexin A5; Apoptosis; Caspase 3; Cation Transport Proteins; Cells, Cultured; DNA Fragmentation; DNA Replication; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Guanidines; Humans; Hydrogen-Ion Concentration; Protein Isoforms; Protein Kinase Inhibitors; Reactive Oxygen Species; Sodium; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones; Thymidine; Time Factors | 2006 |
Clusterin enhances proliferation of primary astrocytes through extracellular signal-regulated kinase activation.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Western; Cell Count; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Clusterin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression; Humans; Male; Mitogen-Activated Protein Kinase Kinases; Oligodeoxyribonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Thymidine; Transfection; Tritium | 2006 |
MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation.
Topics: Blotting, Western; Carbachol; Cell Line; Cell Proliferation; Cholinergic Agonists; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Humans; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, Muscarinic; Signal Transduction; Thymidine; Tritium | 2007 |
Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling.
Topics: Animals; Calpain; Cell Line; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Escherichia coli; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Fluorescent Antibody Technique, Direct; Ligands; Luciferases; Mice; Plasmids; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Signal Transduction; Tenascin; Thymidine; Time Factors; Transfection; Transformation, Genetic | 2008 |
A possible impaired signaling mechanism in human retinal pigment epithelial cells from patients with macular degeneration.
Topics: Case-Control Studies; Cell Count; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Humans; Insulin; Macular Degeneration; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pigment Epithelium of Eye; Precipitin Tests; Signal Transduction; Thymidine | 2008 |
Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells.
Topics: Animals; Blotting, Western; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavanones; Flavonoids; G1 Phase; Genes, ras; Immunoprecipitation; Mutation; Myocytes, Smooth Muscle; raf Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Thymidine; Transfection | 2008 |
Inhibition of MAPK/ERK, PKC and CaMKII signaling blocks cytolysin-induced human glioma cell death.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Line, Tumor; Cnidarian Venoms; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioblastoma; Humans; MAP Kinase Signaling System; Marine Toxins; Mitogen-Activated Protein Kinases; Perforin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Staurosporine; Thymidine | 2010 |
Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells.
Topics: Adenocarcinoma; Barrett Esophagus; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Esophageal Neoplasms; Flavonoids; Humans; Hydrogen Peroxide; Luciferases; Membrane Proteins; Mitogen-Activated Protein Kinases; NADPH Oxidase 5; NADPH Oxidases; NF-kappa B; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Thymidine; Transfection | 2011 |