pd 98059 has been researched along with sirolimus in 167 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 44 (26.35) | 18.2507 |
| 2000's | 98 (58.68) | 29.6817 |
| 2010's | 25 (14.97) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Azpiazu, I; DePaoli-Roach, AA; Lawrence, JC; Saltiel, AR | 1 |
| Giasson, E; Meloche, S; Servant, MJ | 1 |
| Granner, DK; Osawa, H; Printz, RL; Robey, RB; Sutherland, C | 1 |
| Hue, L; Lefebvre, V; Louckx, MP; Méchin, MC; Rider, MH | 1 |
| Backer, JM; Chen, D; McIlroy, J; Michaeli, T; Wjasow, C | 1 |
| LeRoith, D; Párrizas, M; Saltiel, AR | 1 |
| Borthwick, AC; Hurel, SJ; Rochford, JJ; Turnbull, DM; Vandenheede, JR; Wells, AM; Yeaman, SJ | 1 |
| Coolican, SA; Ewton, DZ; Florini, JR; McWade, FJ; Samuel, DS | 1 |
| DaSilva, L; Erwin, RA; Farrar, WL; Hennighausen, L; Kirken, RA; Liu, X; Malabarba, MG; Rui, H; Xu, J | 1 |
| Gunn-Moore, FJ; Tavaré, JM; Toms, NJ; Williams, AG | 1 |
| Fraser, C; Morley, S | 1 |
| Lawrence, JC; Scott, PH | 1 |
| Fertel, R; Rampersaud, AA; Van Brocklyn, JR; Vandenheede, JR; Yates, AJ | 1 |
| McKendrick, L; Morley, SJ | 1 |
| Klip, A; McCall, A; Taha, C; Tsakiridis, T | 1 |
| Freissmuth, M; Hutter, C; Karel, A; Schütz, W; Sexl, V; Zezula, J | 1 |
| Carlsen, J; Christiansen, K; Vinten, J | 1 |
| Fryer, LG; Holness, MJ; Sugden, MC | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Brindley, DN; O'Brien, L; Wang, CN | 1 |
| Belfrage, P; Degerman, E; Landström, TR; Manganiello, V; Wijkander, J | 1 |
| Horetsky, RL; Jefferson, LS; Kimball, SR | 1 |
| Foncea, R; Lavandero, S; Pérez, V; Sapag-Hagar, M | 1 |
| Brambilla, E; Kahn, CR; Landaker, EJ; Luzi, L; Patti, ME | 1 |
| Kanatsuka, A; Makino, H; Onuma, H; Osawa, H; Saito, Y; Suzuki, Y; Taira, M | 1 |
| Anand-Srivastava, MB; Pandey, SK; Srivastava, AK | 1 |
| Garlock, GL; Jivraj, S; Stapleton, SR; Wagle, A | 1 |
| Cowen, DS; Mysels, DJ; Pullarkat, SR; Tan, M | 1 |
| Klip, A; Somwar, R; Sumitani, S; Sweeney, G; Taha, C | 1 |
| Anand-Srivastava, MB; Ge, C | 1 |
| Eyers, PA; Hundal, HS; McDowell, HE | 1 |
| Inoue, K; Iwasaki, Y; Mutsuga, N; Niiori-Onishi, A; Oiso, Y; Saito, H | 1 |
| Cohen, P; Cuenda, A | 1 |
| Allen, MP; Basilico, C; Bellosta, P; Heidenreich, KA; Meintzer, MK; Schneider, K; Varnum, B; Wierman, ME; Xiong, X; Zeng, C | 1 |
| Anderson, NG; Houslay, MD; Kilgour, E; Sale, EM; Sale, GJ; Yarwood, SJ | 1 |
| DeFea, K; Li, J; Roth, RA | 1 |
| Marsh, JD; Ritchie, RH; Schiebinger, RJ | 1 |
| Schrör, K; Weber, AA; Zucker, TP | 1 |
| Dardevet, D; Grizard, J; Sornet, C | 1 |
| Chambard, JC; Pouysségur, J; Viñals, F | 1 |
| Bussolati, O; Dall'Asta, V; Franchi-Gazzola, R; Gazzola, GC; Visigalli, R | 1 |
| Roques, M; Vidal, H | 1 |
| Carlsen, J; Christiansen, K; Grunnet, N; Vinten, J | 1 |
| Gressner, AM; Jansson, JO; Skrtic, S; Wallenius, K | 1 |
| Sánchez-Margalet, V | 1 |
| Apostolova, MD; Cherian, MG; Ivanova, IA | 1 |
| Bansal, R; Baron, W; de Vries, H; Hoekstra, D; Metz, B | 1 |
| Proud, CG; Wang, L; Wang, X | 1 |
| Cadilla, CL; Jimenez, BD; Longo, N; Meléndez, PA | 1 |
| Fukazawa, H; Uehara, Y | 1 |
| Suzuki, K; Takahashi, K | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Böhm, M; Geisler, M; Mies, F; Nohr, T; Schnabel, P | 1 |
| Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Sasaoka, T; Takano, A; Ueno, E; Uno, T; Usui, I | 1 |
| Abe, S; Adachi, S; Hiroe, M; Ito, H; Marumo, F; Nozato, T; Ono, Y; Tamamori, M | 1 |
| Kar, S; Quirion, R; Zheng, WH | 1 |
| Dirks, WG; Drexler, HG; Fleckenstein, D; Quentmeier, H; Zaborski, M | 1 |
| Fando, JL; Martín, ME; Muñoz, FM; Salinas, M | 1 |
| Araki, M; Fujita, M; Hasegawa, K; Iwai-Kanai, E; Kakita, T; Morimoto, T; Sasayama, S; Sawamura, T; Wada, H | 1 |
| Balage, M; Dardevet, D; Grizard, J; Sornet, C | 1 |
| Khandelwal, RL; Syed, NA | 1 |
| Chan, JL; Nguyen, KT; Wang, LH; Wang, WJ | 1 |
| Beale, G; Cross, J; England, K; Rumsby, M; Warner, M; Watson, J | 1 |
| Joaquin, M; Tauler, A | 1 |
| Chen, CS; Dods, P; Gagnon, A; Roustan-Delatour, N; Sorisky, A | 1 |
| Carrillo, JJ; Esteban-Gamboa, A; Felíu, JE; Ibares, B | 1 |
| Chaudhary, LR; Hruska, KA | 1 |
| Bode, AM; Chen, N; Dong, Z; Nomura, M; Zhang, Y; Zhong, S | 1 |
| Callery, MP; Elbirt, KK; Potter, MW; Shah, SA | 1 |
| Inaguma, Y; Ito, H; Iwamoto, I; Kamei, K; Kato, K | 1 |
| Borski, R; Fruchtman, S; Gift, B; Howes, B | 1 |
| Claes, P; Grobben, B; Roymans, D; Slegers, H | 1 |
| Bazan, HE; Chandrasekher, G; Kakazu, AH | 1 |
| Hara, K; Kawamura, M; Nawa, H; Takei, N; Yonezawa, K | 1 |
| Bai, G; Kusiak, JW; Liu, A; Mei, L; Norton, DD; Prenger, MS | 1 |
| Corwin, JT; Montcouquiol, M; Witte, MC | 1 |
| Brodde, OE; Goldberg, M; Heinroth-Hoffmann, I; Osten, B; Piper, HM; Pönicke, K; Schlüter, KD; Seyfarth, T | 1 |
| Bode, AM; Dong, Z; Liu, G; Ma, WY; Zhang, Y | 1 |
| Brattain, MG; Dawson, DM; Gupta, A; St Clair, P; Venkateswarlu, S; Willson, JK | 1 |
| Bhanot, M; Chan, JL; Le, MT; Nguyen, KT; Sachdev, P; Uttamsingh, S; Wang, LH; Zong, CS | 1 |
| Gera, J; Hsu, JH; Hu, L; Lichtenstein, A; Shi, Y | 1 |
| Cohen, P; Peggie, M; Prescott, AR; Rena, G; Unterman, TG; Williams, MR; Woods, YL | 1 |
| Peppelenbosch, MP; Petersen, LC; Richel, DJ; Slofstra, SH; Stam, JC; Sørensen, BB; van Bergen en Henegouwen, PM; Van den Brande, JH; Versteeg, HH | 1 |
| Cruciani, V; Mikalsen, SO | 1 |
| Fenton, RG; Zhang, B | 1 |
| Block, ER; Li, YD; Patel, JM | 1 |
| Fukazawa, H; Murakami, Y; Noguchi, K; Uehara, Y | 1 |
| Eggo, MC; Holder, JC; Kumar, S; Patel, NG; Smith, SA | 1 |
| Gera, J; Hsu, JH; Hu, L; Lichtenstein, A; Shi, Y; Van Ness, B | 1 |
| Easton, J; Germain, GS; Harwood, FC; Houghton, PJ; Huang, S; Thimmaiah, KN; Veverka, KA | 1 |
| Brodt, P; Zhang, D | 1 |
| Akamatsu, S; Hatakeyama, D; Kozawa, O; Oiso, Y; Shibata, T; Tokuda, H | 1 |
| Lee, JC; Shoba, LN | 1 |
| Calvo, V; Gomez-Cambronero, J; Lehman, JA | 1 |
| Hori, T; Kawamata, T; Shin-ya, K; Yamaguchi, T | 1 |
| Gomez-Cambronero, J | 1 |
| Angelovska, T; Borowiec, AM; Dixon, IM; Freed, DH | 1 |
| Bar-Eli, M; Brodt, P; Meloche, S; Zhang, D | 1 |
| Acitores, A; González, N; Sancho, V; Valverde, I; Villanueva-Peñacarrillo, ML | 2 |
| Daigle, C; Dao, HH; Girardot, D; Martens, FM; Moreau, P; Touyz, RM | 1 |
| Sans, MD; Williams, JA; Xie, Q | 1 |
| Allen, WE; Campbell, M; Sawyer, C; Trimble, ER; Vanhaesebroeck, B | 1 |
| Hausenloy, DJ; Mocanu, MM; Yellon, DM | 1 |
| Audigier, Y; Cornu, M; Knibiehler, B; Masri, B; Morin, N | 1 |
| Li, W; Sumpio, BE | 1 |
| Davies, MG; Fegley, AJ; Kim, D; Nicholl, SM; Roztocil, E; Tanski, WJ | 1 |
| Al-Shami, R; Andersson, G; Carson, DD; Ek-Rylander, B; Farach-Carson, MC; Sorensen, ES | 1 |
| de las Heras, M; Fan, H; Fu, W; Maeda, N; Ortin, A | 1 |
| Ihjima, K; Kawauchi, K; Yamada, O | 1 |
| Axelson, J; Hörlin, K; Lindell, M; Ohlsson, B | 1 |
| Orsulic, S; Xing, D | 1 |
| Fang, CH; Hasselgren, PO; Li, BG | 1 |
| Akagawa, K; Omura, T; Osawa, M; Sawai, T; Sunazuka, T | 1 |
| Inamura, N; Nawa, H; Takei, N | 1 |
| Block, ER; Lu, J; Patel, JM; Zhang, J | 1 |
| Dupont-Versteegden, EE; Fluckey, JD; Gaddy, D; Knox, M; Peterson, CA; Smith, L; Tesch, PA | 1 |
| Bienengraeber, M; Kersten, JR; Krolikowski, JG; Pagel, PS; Warltier, DC; Weihrauch, D | 1 |
| Chelucci, C; Gabbianelli, M; Guerriero, R; Parolini, I; Peschle, C; Petrucci, E; Samoggia, P; Sargiacomo, M; Testa, U | 1 |
| Duleba, AJ; Foyouzi, N; Kwintkiewicz, J; Pehlivan, T; Spaczynski, RZ | 1 |
| Bauer, AL; Czyzyk-Krzeska, MF; Hui, AS; Schnell, PO; Striet, JB | 1 |
| Babó, I; Harisi, R; Jeney, A; Kenessey, I; Oláh, J; Pogány, G; Timár, F | 1 |
| Hanai, Y; Kozawa, O; Takai, S; Tokuda, H | 1 |
| Florian, S; Gleixner, KV; Gruze, A; Kondo, R; Mayerhofer, M; Pickl, WF; Rebuzzi, L; Sonneck, K; Thalhammer, JG; Valent, P; Vales, A; Willmann, M | 1 |
| Kimura, M; Ogihara, M; Okamoto, H | 1 |
| Cigorraga, SB; Galardo, MN; Meroni, SB; Pellizzari, EH; Riera, MF | 1 |
| Kersten, JR; Krolikowski, JG; Pagel, PS; Pratt, PF; Shim, YH; Venkatapuram, S; Warltier, DC; Weihrauch, D | 1 |
| Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW | 1 |
| Han, HJ; Lee, MY; Lee, SH | 1 |
| Fang, JY; Shen, GF; Sun, DF; Zhang, YJ; Zhao, SL; Zheng, Q; Zhu, HY | 1 |
| Kawano, F; Nakai, N; Ohira, T; Ohira, Y; Oke, Y; Terada, M | 1 |
| Furukawa, Y; Inaba, T; Kurosawa, H; Masuda, M; Matsui, H; Miyagi, J; Nagasaki, A; Ohama, K; Shinjyo, T; Takasu, N | 1 |
| Aslanidis, C; Buechler, C; Gerl, M; Gindner, A; Neumeier, M; Schäffler, A; Schölmerich, J; Wanninger, J; Weigert, J; Wurm, S | 1 |
| Blümer, RM; Dubbelhuis, PF; Houben-Weerts, JH; Meijer, AJ; Sauerwein, HP; van Roomen, CP | 1 |
| Codeluppi, S; Hefferan, MP; Marsala, M; Oshiro, M; Pasquale, EB; Silldorff, MD; Svensson, CI; Valencia, F | 1 |
| Fang, JY; Sun, DF; Tian, XQ; Xiong, H; Zhang, YJ; Zhao, SL | 1 |
| Chintalwar, GJ; Khanam, S; Raghu, R; Ramakrishnan, R; Sainis, KB; Sharma, D | 1 |
| Altamirano, F; Estrada, M; Lavandero, S; Oyarce, C; Silva, P; Toyos, M; Uhlén, P; Wilson, C | 1 |
| Blagosklonny, MV; Demidenko, ZN; Shtutman, M | 1 |
| Li, L; Ma, J; Mi, R; Zhang, D; Zhang, H | 1 |
| Adachi, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Natsume, H; Otsuka, T; Tokuda, H; Yamauchi, J | 1 |
| Arita, M; Ohira, T; Omori, K; Recchiuti, A; Serhan, CN; Van Dyke, TE | 1 |
| Blanc, M; Cordier-Bussat, M; Couderc, C; Gouysse, G; Nejjari, M; Roche, C; Scoazec, JY; Vercherat, C; Villaume, K; Walter, T | 1 |
| Chen, L; Chen, W; Han, X; Huang, S; Liu, L; Luo, Y; Shen, T; Xu, B; Zhou, H | 1 |
| Chin, TY; Chueh, SH; Huang, WP; Kao, CH; Ma, KH; Wang, HY | 1 |
| Darbre, PD; Fry, MJ; Ray, S | 1 |
| Connor, SA; Hoeffer, CA; Klann, E; Nguyen, PV | 1 |
| Evers, BM; Gao, T; Li, J; Liu, J; Song, J; Townsend, CM; Wang, X; Weiss, HL | 1 |
| Arnold, W; Beck, C; Boulesteix, AL; Knopf, A; Margraf, J; Pickhard, AC; Pigorsch, S; Piontek, G; Reiter, R; Scherer, EQ; Schlegel, J; Stark, T | 1 |
| Curran, WJ; Deng, X; Khuri, FR; Liu, Y; Owonikoko, TK; Sica, GL; Sun, SY | 1 |
| Gu, SH; Li, S; Lin, PL; Yeh, WL; Young, SC | 1 |
| Jhiang, SM; Liu, YY; Ringel, MD; Zhang, X | 1 |
| Aparicio, C; González, N; Jensen, RT; Mantey, SA; Martín-Duce, A; Moreno-Villegas, Z; Portal-Núñez, S; Ramos-Álvarez, I; Sanz, R | 1 |
| Amagai, Y; Ishizaka, S; Jang, H; Jung, K; Matsuda, A; Matsuda, H; Nishikawa, S; Oida, K; Tanaka, A | 1 |
| DiGiovanni, J; Jiang, G; Kiguchi, K; Rho, O | 1 |
| Chang, J; Cheng, L; Ji, D; Li, J; Liu, R; Liu, X; Sun, Z; Wang, C; Wang, S; Wang, X; Zhang, X; Zhang, Z; Zheng, B; Zheng, R | 1 |
| Ma, WY; Zhang, J | 1 |
| Chang, KT; Chen, HC; Hung, CC; Hung, CH; Hwang, SJ; Kuo, CH; Lin, HY; Lin, SF | 1 |
| Kimura, M; Moteki, H; Ogihara, M | 1 |
| Björnsson, BT; Einarsdottir, IE; Fuentes, EN; Hidalgo, C; Molina, A; Paredes, R; Valdes, JA | 1 |
| Chauski, EI; Khaliulin, IG; Maslov, LN; Mukhomedzyanov, AV; Portnichenko, AG; Tsibulnikov, SY | 1 |
| Chen, L; Gao, W; Huang, S; Liu, C; Wang, X; Xu, C; Zhang, H; Zhu, Y | 1 |
| Archambault, E; Cynober, L; Goron, A; Guihenneuc, C; Jourdan, M; Le Plénier, S; Moinard, C; Neveux, N; Salles, J; Sotiropoulos, A; Walrand, S | 1 |
| Fujita, K; Kainuma, S; Kawabata, T; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Otsuka, T; Sakai, G; Tokuda, H; Yamamoto, N | 1 |
2 review(s) available for pd 98059 and sirolimus
| Article | Year |
|---|---|
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
[Study of drugs against neoplastic metastasis].
Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibitors; Fatty Alcohols; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Morpholines; Neoplasm Metastasis; Paclitaxel; Pyridines; Ribavirin; Signal Transduction; Sirolimus | 2006 |
165 other study(ies) available for pd 98059 and sirolimus
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Diaphragm; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glycogen Synthase; Homeostasis; Immune Sera; In Vitro Techniques; Insulin; Intracellular Signaling Peptides and Proteins; Kinetics; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Skeletal; Peptides; Phosphoproteins; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors | 1996 |
Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Growth Substances; Insulin; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Smooth, Vascular; Phosphorylation; Polyenes; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; Sirolimus; Substrate Specificity; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin.
Topics: Adipose Tissue; Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose Transporter Type 4; Hexokinase; Insulin; Insulin Antagonists; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Myocardium; Polyenes; Rats; RNA, Messenger; Signal Transduction; Sirolimus; Transcription, Genetic; Wortmannin | 1996 |
Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fructosediphosphates; Glycolysis; In Vitro Techniques; Insulin; Insulin Antagonists; Mitogen-Activated Protein Kinase 1; Models, Biological; Myocardium; Phosphatidylinositol 3-Kinases; Phosphofructokinase-2; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1996 |
Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways.
Topics: Animals; Antibodies; Antibody Specificity; Carrier Proteins; Cattle; CHO Cells; Cricetinae; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; MAP Kinase Kinase Kinase 1; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 1997 |
Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways.
Topics: Androstadienes; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Drug Synergism; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Morpholines; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1997 |
Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Insulin; Muscle, Skeletal; Polyenes; Protein Kinases; Signal Transduction; Sirolimus; Wortmannin | 1996 |
The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Developmental; Genes, fos; Insulin-Like Growth Factor I; Mitogens; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Somatomedins | 1997 |
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1997 |
Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival.
Topics: Amino Acid Sequence; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Polyenes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Ribosomal Protein S6 Kinases; Sirolimus | 1997 |
Studies on the phosphorylation of eIF4E in Xenopus (XIK-2) kidney cells.
Topics: Animals; Cell Line; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Immunosuppressive Agents; Indoles; Kidney; Kinetics; Peptide Initiation Factors; Phosphorylation; Polyenes; Protein Kinase C; Sirolimus; Tetradecanoylphorbol Acetate; Xenopus | 1997 |
Insulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Enzyme Activation; Eukaryotic Initiation Factors; Flavonoids; Humans; Insulin; Mice; Phosphoproteins; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Swine | 1997 |
Ganglioside GM1 activates the mitogen-activated protein kinase Erk2 and p70 S6 kinase in U-1242 MG human glioma cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Cyclic AMP; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G(M1) Ganglioside; Glioma; Humans; Immunosuppressive Agents; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogens; Platelet-Derived Growth Factor; Polyenes; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 1997 |
Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Flavonoids; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Ribosomal Protein S6 Kinases; Ribosomes; Signal Transduction; Sirolimus | 1997 |
Glucose transporter expression in L6 muscle cells: regulation through insulin- and stress-activated pathways.
Topics: 2,4-Dinitrophenol; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypertonic Solutions; Imidazoles; Insulin; Kinetics; Mannitol; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Monosaccharide Transport Proteins; Muscle, Skeletal; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stress, Physiological; Uncoupling Agents | 1997 |
The cyclin-dependent kinase inhibitor p21cip1 mediates the growth inhibitory effect of phorbol esters in human venous endothelial cells.
Topics: Cell Division; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; G1 Phase; Humans; Indoles; Maleimides; Phorbol 12,13-Dibutyrate; Polyenes; Protein Kinase C; RNA, Messenger; Signal Transduction; Sirolimus; Tumor Suppressor Protein p53 | 1997 |
Insulin stimulated glycogen synthesis in isolated rat hepatocytes: effect of protein kinase inhibitors.
Topics: Androstadienes; Animals; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Hypoglycemic Agents; Insulin; Liver; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1997 |
Selective modification of insulin action in adipose tissue by hyperthyroidism.
Topics: Adipose Tissue; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Nonesterified; Female; Flavonoids; Glucose; Hyperthyroidism; Insulin; Insulin Antagonists; Lipid Metabolism; Lipolysis; Norepinephrine; Polyenes; Rats; Rats, Wistar; Sirolimus; Triiodothyronine; Wortmannin | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cell Membrane Permeability; Ceramides; Chromones; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Mice; Models, Biological; Monosaccharide Transport Proteins; Morpholines; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polyenes; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha | 1998 |
Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Flavonoids; Insulin; Male; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 1998 |
Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts.
Topics: Androstadienes; Animals; Carrier Proteins; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Flavonoids; Insulin; Muscle, Skeletal; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Polyenes; Protein Biosynthesis; Repressor Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1998 |
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Heart; Heart Ventricles; Insulin-Like Growth Factor I; Myocardium; Phosphorylation; Polyenes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Sirolimus; Staurosporine; Wortmannin | 1998 |
Bidirectional modulation of insulin action by amino acids.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cells, Cultured; Enzyme Activation; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin; Insulin Receptor Substrate Proteins; Liver; Phosphatidylinositol 3-Kinases; Phosphoproteins; Polyenes; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1998 |
Mitogen-activated protein kinase and p70 ribosomal protein S6 kinase are not involved in the insulin-dependent stimulation of cAMP phosphodiesterase kinase in rat adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Amino Acid Sequence; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell-Free System; Chromones; Epidermal Growth Factor; Epididymis; Flavonoids; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Male; Molecular Sequence Data; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Polyenes; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 1998 |
Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; Enzyme Activation; Flavonoids; Glycogen; Humans; Insulin Receptor Substrate Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polyenes; Receptor, Insulin; Ribosomal Protein S6 Kinases; Sirolimus; Tyrosine; Vanadium Compounds; Wortmannin | 1998 |
Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Flavonoids; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Insulin; Liver; Lovastatin; Male; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Wortmannin | 1998 |
Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase (ERK-2) and p70 S6 kinase signaling systems.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Mice; Mitogen-Activated Protein Kinase 1; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Receptors, Serotonin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Virulence Factors, Bordetella | 1998 |
Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms.
Topics: Androstadienes; Animals; Cell Line; Chromones; Clone Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Homeostasis; Indoles; Insulin; Kinetics; Maleimides; Models, Biological; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors; Wortmannin | 1998 |
Involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in AII-mediated enhanced expression of Gi proteins in vascular smooth muscle cells.
Topics: Androstadienes; Angiotensin II; Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dactinomycin; Embryo, Mammalian; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Protein Biosynthesis; Rats; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Transcription, Genetic; Wortmannin | 1998 |
Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress.
Topics: Amino Acids; Androstadienes; Animals; Arsenites; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hot Temperature; Insulin; Kinetics; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction; Sirolimus; Sodium Compounds; Wortmannin | 1998 |
Molecular mechanisms of the negative effect of insulin-like growth factor-I on growth hormone gene expression in MtT/S somatotroph cells.
Topics: Androstadienes; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Genistein; Growth Hormone; Growth Inhibitors; Insulin; Insulin-Like Growth Factor I; Luciferases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Transfection; Tumor Cells, Cultured; Wortmannin | 1999 |
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Muscle Development; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Ribosomal Protein S6 Kinases; Sirolimus | 1999 |
Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
Topics: Androstadienes; Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation, Developmental; Gonadotropin-Releasing Hormone; Humans; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Mice; Microscopy, Fluorescence; Neurons; Oncogene Proteins; Precipitin Tests; Proteins; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Sirolimus; Wortmannin | 1999 |
Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Growth Hormone; Insulin; Janus Kinase 2; Mice; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligonucleotides, Antisense; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Triiodothyronine | 1999 |
Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway.
Topics: 3T3 Cells; Adipocytes; Animals; Endothelin-1; Flavonoids; Insulin; Insulin Receptor Substrate Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sirolimus; Tyrosine | 1999 |
Bradykinin-stimulated protein synthesis by myocytes is dependent on the MAP kinase pathway and p70(S6K).
Topics: Angiotensin II; Animals; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Male; Muscle Proteins; Myocardium; Phenylalanine; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus | 1999 |
Platelet surface membranes are highly mitogenic for coronary artery smooth muscle cells--A novel mechanism for sustained proliferation after vessel injury?
Topics: Androstadienes; Animals; Antibodies; Becaplermin; Blood Platelets; Cattle; Cell Division; Cell Membrane; Cells, Cultured; Chlorobenzenes; Coronary Vessels; DNA; Flavonoids; Hot Temperature; Mitogens; Muscle, Smooth, Vascular; Phthalimides; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Sirolimus; Wortmannin | 1999 |
Glucocorticoid-induced insulin resistance of protein synthesis is independent of the rapamycin-sensitive pathways in rat skeletal muscle.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dexamethasone; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Insulin Resistance; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus | 1999 |
p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; DNA Replication; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; G1 Phase; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Biosynthesis; Ribosomal Protein S6 Kinases; Sirolimus; Thymidine | 1999 |
Adaptive increase of amino acid transport system A requires ERK1/2 activation.
Topics: Amino Acids; Androstadienes; beta-Alanine; Biological Transport; Carrier Proteins; Cell Size; Culture Media; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Hypertonic Solutions; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Sirolimus; Wortmannin | 1999 |
A phosphatidylinositol 3-Kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells.
Topics: Adult; Cells, Cultured; Chromones; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glycogen Synthase; Humans; Insulin; Insulin Receptor Substrate Proteins; Middle Aged; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Transcription, Genetic | 1999 |
Involvement of PI 3-kinase and activated ERK in facilitating insulin-stimulated triacylglycerol synthesis in hepatocytes.
Topics: Acetyl-CoA Carboxylase; Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Glucose; Insulin; Liver; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sirolimus; Triglycerides; Wortmannin | 1999 |
Insulin-like growth factor signaling pathways in rat hepatic stellate cells: importance for deoxyribonucleic acid synthesis and hepatocyte growth factor production.
Topics: Animals; Chromones; DNA; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Liver; Male; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus | 1999 |
Stimulation of glycogen synthesis by insulin requires S6 kinase and phosphatidylinositol-3-kinase in HTC-IR cells.
Topics: Animals; Chromones; Enzyme Inhibitors; Flavonoids; Glycogen; Glycogen Synthase; Humans; Immunophilins; Insulin; Insulin Receptor Substrate Proteins; Isoenzymes; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus Binding Proteins; Tumor Cells, Cultured; Tyrosine | 2000 |
Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cell Nucleus; Chromones; Cytoplasm; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Metallothionein; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Sirolimus; Zinc | 2000 |
PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Pyridines; Pyrrolidinones; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stem Cells | 2000 |
Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps.
Topics: Age Factors; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Heart Ventricles; Hypoglycemic Agents; Immunosuppressive Agents; Insulin; Intracellular Signaling Peptides and Proteins; Methionine; Morpholines; Muscle Fibers, Skeletal; Myocardium; Peptide Elongation Factor 2; Peptide Initiation Factors; Phenylalanine; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Sulfur Radioisotopes; Tritium | 2000 |
Insulin-induced gene 33 mRNA expression in Chinese hamster ovary cells is insulin receptor dependent.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Blotting, Northern; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glucose; Humans; Immunoblotting; Insulin; Naphthalenes; Organophosphonates; Phosphorylation; Protein Binding; Protein Biosynthesis; Protein-Tyrosine Kinases; Proteins; Receptor, ErbB-2; Receptor, Insulin; Signal Transduction; Sirolimus; Time Factors; Transfection; Tumor Suppressor Proteins; Wortmannin | 2000 |
U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways.
Topics: Animals; Butadienes; Cell Line, Transformed; Cell Size; Cell Transformation, Neoplastic; Contact Inhibition; Drug Synergism; Enzyme Activation; Fibroblasts; Flavonoids; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Oncogene Protein p21(ras); Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Sirolimus | 2000 |
Anchorage-independent activation of mitogen-activated protein kinase through phosphatidylinositol-3 kinase by insulin-like growth factor I.
Topics: Breast Neoplasms; Cell Adhesion; Chromones; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2000 |
Differential regulation of phospholipase C-beta isozymes in cardiomyocyte hypertrophy.
Topics: Androstadienes; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Growth Hormone; Insulin-Like Growth Factor I; Isoenzymes; Norepinephrine; Oligonucleotides, Antisense; Phospholipase C beta; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sirolimus; Type C Phospholipases; Wortmannin | 2000 |
Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Androstadienes; Animals; Cell Differentiation; Clone Cells; Dexamethasone; Flavonoids; Insulin; Insulin Antagonists; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Retinoblastoma Protein; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2000 |
Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes.
Topics: Actins; Animals; Cardiomegaly; Cell Culture Techniques; Cell Size; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Mitogen-Activated Protein Kinases; Myocardium; Phenotype; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus | 2000 |
Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Mice; Mutagenesis; Myristic Acid; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transcription Factors; Transfection; Vanadates; Wortmannin | 2000 |
Tumor necrosis factor-alpha-induced proliferation requires synthesis of granulocyte-macrophage colony-stimulating factor.
Topics: Apoptosis; Cell Division; Cytokines; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Leukemia, Myeloid; Myeloid Cells; NF-kappa B; Sirolimus; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation | 2000 |
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells.
Topics: Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Survival; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Flavonoids; Glucose; Hypoxia; Imidazoles; Intracellular Signaling Peptides and Proteins; Ischemia; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Binding; Protein Synthesis Inhibitors; Pyridines; Rats; Sirolimus; Time Factors | 2000 |
Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Anti-Bacterial Agents; Apoptosis; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Heart; Indoles; Isoproterenol; Myocardium; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sirolimus | 2000 |
Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age.
Topics: Aging; Amino Acids; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Leucine; Male; Morpholines; Muscle Proteins; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Sirolimus | 2000 |
Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hepatocytes; Humans; Insulin; Marine Toxins; Mitogen-Activated Protein Kinases; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromones; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Intestinal Mucosa; Mitogen-Activated Protein Kinases; Morpholines; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Receptor, IGF Type 1; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.
Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection | 2001 |
Insulin inhibits glucocorticoid-stimulated L-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by activation of the c-Jun N-terminal kinase pathway.
Topics: Animals; Chromones; Dexamethasone; Enzyme Inhibitors; Flavonoids; Fructose-Bisphosphatase; Gene Expression Regulation; Insulin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; Multienzyme Complexes; Phosphofructokinase-1; Phosphofructokinase-2; Plasmids; Rats; RNA, Messenger; Signal Transduction; Sirolimus; Transfection; Tumor Cells, Cultured | 2001 |
Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Apoptosis; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sirolimus; Wortmannin | 2001 |
Involvement of both phosphatidylinositol 3-kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocytes; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyruvate Kinase; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 2001 |
The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells.
Topics: 3T3 Cells; Androstadienes; Animals; Becaplermin; Blotting, Western; Cell Division; Cell Survival; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Ribosomal Protein S6 Kinases; Ribs; Signal Transduction; Sirolimus; Wortmannin | 2001 |
Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.
Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Subunits; Pyridines; Ribosomal Protein S6 Kinases; Sirolimus; Transfection; Ultraviolet Rays; Wortmannin | 2001 |
Endotoxin (LPS) stimulates 4E-BP1/PHAS-I phosphorylation in macrophages.
Topics: Animals; Carrier Proteins; Cell Line; Cells, Cultured; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Pyridines; Rats; Sirolimus | 2001 |
Regulation of the levels of small heat-shock proteins during differentiation of C2C12 cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line; Creatine Kinase; Creatine Kinase, MM Form; Crystallins; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Isoenzymes; Mice; Molecular Chaperones; Muscle, Skeletal; Neoplasm Proteins; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Sirolimus; Transcription Factors | 2001 |
Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways.
Topics: Animals; Bass; Chromones; Flavonoids; Growth Hormone; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prolactin; Signal Transduction; Sirolimus | 2001 |
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoquinones; Cell Differentiation; Chromones; Cyclic AMP; Enzyme Inhibitors; Flavonoids; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Indoles; Isoproterenol; Isoquinolines; Lactams, Macrocyclic; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sirolimus; Sulfonamides; Tumor Cells, Cultured; Wortmannin | 2001 |
HGF- and KGF-induced activation of PI-3K/p70 s6 kinase pathway in corneal epithelial cells: its relevance in wound healing.
Topics: Androstadienes; Animals; Cell Communication; Enzyme Inhibitors; Epithelium, Corneal; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Hepatocyte Growth Factor; MAP Kinase Signaling System; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rabbits; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin; Wound Healing | 2001 |
Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Brain; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Insulin; MAP Kinase Signaling System; Methionine; Morpholines; Neurons; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Biosynthesis; Rats; Signal Transduction; Sirolimus; Time Factors; Up-Regulation | 2001 |
Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter.
Topics: Androstadienes; Animals; Cell Nucleus; DNA; Enzyme Inhibitors; Flavonoids; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Nerve Growth Factor; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sirolimus; Sp1 Transcription Factor; Transfection; Up-Regulation; Wortmannin | 2001 |
Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry.
Topics: Androstadienes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apigenin; Blood Proteins; Butadienes; Cell Division; Chickens; Chromones; Enzyme Inhibitors; Flavonoids; Hair Cells, Auditory; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Regeneration; Ribosomal Protein S6 Kinases; S Phase; Sirolimus; Wortmannin | 2001 |
Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of only alpha1A-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Flavonoids; Heart; Inositol Phosphates; Male; Myocardium; Norepinephrine; Protein Biosynthesis; Rats; Receptors, Adrenergic, alpha-1; Ribosomal Protein S6 Kinases; Sirolimus | 2001 |
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.
Topics: Androstadienes; Carrier Proteins; Eukaryotic Initiation Factor-4E; Flavonoids; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Sulfonamides; Ultraviolet Rays; Wortmannin | 2002 |
Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells.
Topics: Adenocarcinoma; Apoptosis; Autocrine Communication; Cell Cycle; Chromones; Colonic Neoplasms; Culture Media; Culture Media, Serum-Free; Dimerization; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Growth Substances; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Neuregulin-1; Neutralization Tests; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Signal Transduction; Sirolimus; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2002 |
The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Chromones; DNA-Binding Proteins; Fibroblasts; Flavonoids; Genes, Dominant; GTP Phosphohydrolases; MAP Kinase Signaling System; Mice; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Repressor Proteins; Sirolimus; STAT3 Transcription Factor; Trans-Activators | 2002 |
Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Carrier Proteins; Cell Cycle Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; Interleukin-6; Kinetics; MAP Kinase Signaling System; Multiple Myeloma; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Repressor Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tumor Cells, Cultured; Wortmannin | 2002 |
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
Topics: Amino Acid Sequence; Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Conserved Sequence; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Humans; Phosphorylation; ran GTP-Binding Protein; Sirolimus; Transcription Factors; Wortmannin | 2002 |
VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cricetinae; Cytoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Factor VIIa; Flavonoids; Glycogen Synthase Kinase 3; Humans; Peptide Initiation Factors; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Sirolimus; Thrombin; Thromboplastin; Time Factors; Transfection; Up-Regulation | 2002 |
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin | 2002 |
Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).
Topics: Antibiotics, Antineoplastic; Blotting, Western; Butadienes; Cell Cycle; Cell Division; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Humans; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Multiple Myeloma; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2002 |
Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Angiotensin II; Animals; Anti-Bacterial Agents; Cell Division; Cells, Cultured; Endothelium; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Swine; Wortmannin | 2002 |
Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway.
Topics: Animals; Anoikis; Antineoplastic Agents; Breast Neoplasms; Butadienes; Cell Division; Cell Line, Transformed; DNA Fragmentation; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Fibroblasts; Flavonoids; Immunoblotting; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Nucleosomes; Phosphorylation; Protein Kinases; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2002 |
Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation.
Topics: Adipocytes; Androstadienes; Cell Differentiation; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leptin; Lipid Metabolism; Lipids; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rosiglitazone; Signal Transduction; Sirolimus; Stem Cells; Thiazoles; Thiazolidinediones; Tumor Necrosis Factor-alpha; Wortmannin | 2003 |
Downstream effectors of oncogenic ras in multiple myeloma cells.
Topics: Alkyl and Aryl Transferases; Cell Cycle; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Farnesyltranstransferase; Flavonoids; Genes, ras; I-kappa B Proteins; Interleukin-6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Multiple Myeloma; Neoplasm Proteins; NF-kappa B; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Trans-Activators; Transfection; Tumor Cells, Cultured | 2003 |
Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.
Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Rhabdomyosarcoma; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2003 |
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Topics: Amino Acid Substitution; Androstadienes; Animals; Carcinoma, Lewis Lung; Chromones; Collagen; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Insulin-Like Growth Factor I; Laminin; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Morpholines; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Point Mutation; Promoter Regions, Genetic; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptor, IGF Type 1; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2003 |
p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts.
Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cell Line; Chromones; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells.
Topics: Alkaline Phosphatase; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Chromones; Enzyme Induction; Enzyme Inhibitors; Fetus; Flavonoids; Insulin-Like Growth Factor I; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Skull; Transforming Growth Factor beta | 2003 |
Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Immunosuppressive Agents; Inhibitory Concentration 50; Kinetics; MAP Kinase Signaling System; Mice; Models, Biological; Neutrophils; Phosphorylation; Precipitin Tests; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Ribosomes; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2003 |
Divergence in signaling pathways involved in promotion of cell viability mediated by bFGF, NGF, and EGF in PC12 cells.
Topics: Animals; Butadienes; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Nerve Growth Factor; Nitriles; PC12 Cells; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction; Sirolimus | 2003 |
Rapamycin inhibits GM-CSF-induced neutrophil migration.
Topics: Actins; Cell Movement; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinase 1; Neutrophils; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus | 2003 |
Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Cytokines; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; Janus Kinase 1; Male; MAP Kinase Signaling System; Morpholines; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Biosynthesis; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Tyrphostins | 2003 |
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
Topics: Androstadienes; Animals; Blotting, Western; Carcinoma, Lewis Lung; Cell Line, Tumor; Chloramphenicol O-Acetyltransferase; Chromones; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Gene Expression Regulation, Enzymologic; Genes, Dominant; Genes, Reporter; Insulin-Like Growth Factor I; Matrix Metalloproteinase 2; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Plasmids; Proto-Oncogene Proteins c-raf; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sirolimus; Time Factors; Tumor Suppressor Proteins; Wortmannin | 2004 |
Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.
Topics: Androstadienes; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glycogen Synthase; In Vitro Techniques; Indoles; Insulin; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Okadaic Acid; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Flavonoids; Irbesartan; Leucine; Male; Mesenteric Arteries; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Tetrazoles | 2004 |
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
Topics: Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cholecystokinin; Cyclic AMP; Dose-Response Relationship, Drug; Elongation Factor 2 Kinase; Enzyme Inhibitors; Flavonoids; Imidazoles; Marine Toxins; Oxazoles; Pancreas; Peptide Elongation Factor 2; Peptides; Phosphorylation; Protein Biosynthesis; Pyridines; Rats; Signal Transduction; Sirolimus; Time Factors | 2004 |
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2004 |
Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning.
Topics: Animals; Blotting, Western; Enzyme Inhibitors; Flavonoids; Ischemic Preconditioning, Myocardial; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus | 2004 |
Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells.
Topics: Animals; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Mitogens; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; src-Family Kinases; Umbilical Cord | 2004 |
Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Animals; Antibiotics, Antineoplastic; Aorta; Carrier Proteins; Cattle; Cell Division; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2005 |
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin | 2005 |
Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin.
Topics: Androstadienes; Animals; Blotting, Western; Cell Movement; Cells, Cultured; Chromones; Flavonoids; Lysophospholipids; Morpholines; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Wortmannin | 2005 |
Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway.
Topics: Blotting, Western; Cell Line, Tumor; Choriocarcinoma; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Humans; Isoelectric Focusing; Morpholines; Osteopontin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases; Sialoglycoproteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2005 |
Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines.
Topics: Animals; Butadienes; Cell Transformation, Viral; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Flavonoids; Jaagsiekte sheep retrovirus; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Methionine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2005 |
IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.
Topics: Cell Line, Transformed; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HSP90 Heat-Shock Proteins; Humans; Interleukin-2; Killer Cells, Natural; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocyte Activation; Macrolides; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; RNA-Directed DNA Polymerase; Sirolimus; Telomerase; TOR Serine-Threonine Kinases; Transcription, Genetic | 2005 |
Inhibition of different intracellular signal cascades in human pancreatic cancer cells.
Topics: Antibiotics, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Division; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Humans; Morpholines; Pancreatic Neoplasms; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2005 |
A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance.
Topics: Animals; Apoptosis; Ascites; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Flavonoids; Mice; Ovarian Neoplasms; Peritoneum; Signal Transduction; Sirolimus; Time Factors; Vascular Endothelial Growth Factor A | 2005 |
Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms.
Topics: Animals; Cells, Cultured; Chromones; Dexamethasone; Dose-Response Relationship, Drug; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Like Growth Factor I; Lithium Chloride; MAP Kinase Signaling System; Models, Biological; Morpholines; Muscle Fibers, Skeletal; Muscle Proteins; Phosphatidylinositol 3-Kinases; Protein Kinases; Rats; Sirolimus; Thiadiazoles; TOR Serine-Threonine Kinases | 2005 |
[Effect of EM201, an in vivo metabolite of erythromycin (EM), on signal transduction of IL-2 receptor].
Topics: Cells, Cultured; Chromones; Erythromycin; Flavonoids; Humans; Monocytes; Morpholines; Receptors, Interleukin-2; Signal Transduction; Sirolimus | 2004 |
Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Drug Interactions; Elongation Factor 2 Kinase; Flavonoids; Gene Expression Regulation; Immunohistochemistry; Microtubule-Associated Proteins; Neurons; Peptide Elongation Factor 1; Phosphorus Isotopes; Phosphorylation; Protein Biosynthesis; Protein Kinases; Rats; Ribosomes; RNA, Double-Stranded; Signal Transduction; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2005 |
Angiotensin IV enhances phosphorylation of 4EBP1 by multiple signaling events in lung endothelial cells.
Topics: Angiotensin II; Animals; Carrier Proteins; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Swine | 2005 |
Insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP kinase pathway.
Topics: Animals; Eukaryotic Initiation Factor-2B; Flavonoids; In Vitro Techniques; Insulin; Male; Mitogen-Activated Protein Kinases; Muscle Proteins; Muscle, Skeletal; Physical Exertion; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus | 2006 |
Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo.
Topics: Anesthetics, Inhalation; Animals; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rabbits; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus | 2006 |
Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes.
Topics: Animals; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Enzyme Activation; Flavonoids; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Megakaryocytes; Phosphatidylinositol 3-Kinases; Ploidies; Protein Kinases; Sirolimus; Thrombopoietin; TOR Serine-Threonine Kinases | 2006 |
Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways.
Topics: Androstadienes; Animals; Carrier Proteins; Cell Proliferation; Cell Survival; Cells, Cultured; Female; Flavonoids; Hydrogen Peroxide; Hypoxanthine; Insulin; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Theca Cells; TOR Serine-Threonine Kinases; Wortmannin | 2006 |
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Benzylamines; Butadienes; Calcium Signaling; Carbazoles; Cell Hypoxia; Cell Line; Cycloheximide; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Ionomycin; Isoquinolines; Kidney; Nitriles; PC12 Cells; Polyribosomes; Protein Biosynthesis; Protein Kinase C-alpha; Protein Kinases; Protein Synthesis Inhibitors; Rats; RNA Caps; RNA, Messenger; RNA, Small Interfering; Sirolimus; Sulfonamides; TOR Serine-Threonine Kinases | 2006 |
Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Cytokine Receptor gp130; Flavonoids; Gene Expression Regulation; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
Detection of vascular endothelial growth factor (VEGF) and VEGF receptors Flt-1 and KDR in canine mastocytoma cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Blotting, Northern; Cell Line, Tumor; Chromones; Dog Diseases; Dogs; Female; Flavonoids; Flow Cytometry; Immunohistochemistry; Male; Mastocytoma; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Hepatocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Tyrphostins; Wortmannin | 2007 |
Participation of phosphatidyl inositol 3-kinase/protein kinase B and ERK1/2 pathways in interleukin-1beta stimulation of lactate production in Sertoli cells.
Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Interleukin-1beta; L-Lactate Dehydrogenase; Lactates; Male; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Sirolimus; Stimulation, Chemical; Transferrin; Wortmannin | 2007 |
Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.
Topics: Androstadienes; Animals; Argon; Atractyloside; Cardiotonic Agents; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heart Ventricles; Helium; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neon; Noble Gases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Wortmannin | 2007 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chromones; Down-Regulation; Flavonoids; Humans; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multiprotein Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Invasiveness; Niacinamide; Nitriles; Phenylurea Compounds; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction; Sirolimus; Skin Neoplasms; Sorafenib; TOR Serine-Threonine Kinases; Transcription Factors; Wortmannin | 2008 |
Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways.
Topics: Animals; Arachidonic Acid; Ascorbic Acid; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Embryonic Stem Cells; Flavonoids; G1 Phase; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation | 2008 |
[Synergistic effect of rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells].
Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Colorectal Neoplasms; Drug Synergism; Flavonoids; HCT116 Cells; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2007 |
Effects of peroxisome proliferator-activated receptor alpha (PPARalpha) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Clofibrate; Elongation Factor 2 Kinase; Eukaryotic Initiation Factors; Flavonoids; Leucine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multienzyme Complexes; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; PPAR alpha; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus | 2008 |
Ras-mediated up-regulation of survivin expression in cytokine-dependent murine pro-B lymphocytic cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Carrier Proteins; Cell Cycle; Cell Line; Chromones; Enhancer Elements, Genetic; Flavonoids; Gene Expression Regulation; Genes, ras; Humans; Inhibitor of Apoptosis Proteins; Interleukin-3; MAP Kinase Signaling System; Mice; Microtubule-Associated Proteins; Morpholines; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Repressor Proteins; Signal Transduction; Sirolimus; Survivin; TOR Serine-Threonine Kinases; Transfection | 2008 |
Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway.
Topics: Androstadienes; Blood Glucose; Body Mass Index; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Female; Flavonoids; Glucose; Humans; Insulin; Interleukin-8; Leukocytes; Male; Monocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin; Young Adult | 2008 |
Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes, White; Adiponectin; Amino Acids; Animals; Carrier Proteins; Cell Differentiation; Chromones; Flavonoids; Hydrogen-Ion Concentration; Insulin; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2008 |
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.
Topics: Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Chromones; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Excitatory Amino Acid Transporter 2; Flavonoids; Glial Fibrillary Acidic Protein; Immunosuppressive Agents; Male; Monomeric GTP-Binding Proteins; Morpholines; Neuropeptides; Protein Kinases; Ras Homolog Enriched in Brain Protein; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sirolimus; Spinal Cord Injuries; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Up-Regulation; Vimentin | 2009 |
Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Progression; Female; Flavonoids; Humans; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2009 |
Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia.
Topics: Adjuvants, Immunologic; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; Carrier Proteins; Cell Line; Cell Proliferation; Chromones; Enzyme Inhibitors; Flavonoids; Lectins, C-Type; Lymphocyte Activation; Macrophages; MAP Kinase Kinase Kinases; Mice; Morpholines; Naphthoquinones; NF-kappa B; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Polysaccharides; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Splenomegaly; Tinospora; Toll-Like Receptor 4; TOR Serine-Threonine Kinases | 2009 |
Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway.
Topics: Androgens; Animals; Calcium; Calcium Signaling; Carrier Proteins; Cells, Cultured; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypertrophy; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; Myocytes, Cardiac; Phosphoproteins; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Small Interfering; Signal Transduction; Sirolimus; Testosterone; TOR Serine-Threonine Kinases; Transcription Factors | 2009 |
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.
Topics: Butadienes; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Chromones; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases | 2009 |
Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2009 |
p70 S6 kinase limits tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Immunosuppressive Agents; Interleukin-6; Mice; Osteoblasts; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Tumor Necrosis Factor-alpha | 2010 |
Resolvin E1 receptor activation signals phosphorylation and phagocytosis.
Topics: Animals; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; Eicosapentaenoic Acid; Flavonoids; HL-60 Cells; Humans; Inflammation; Lipids; Macrophages; Phagocytosis; Phosphorylation; Receptors, Chemokine; Sirolimus; Zymosan | 2010 |
VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chromones; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mice; Morpholines; Neuroendocrine Tumors; Octreotide; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Sirolimus; Somatostatin; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2010 |
Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway.
Topics: Cell Line, Tumor; Cell Movement; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genes, Dominant; Humans; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Okadaic Acid; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2010 |
Inhibition of the mammalian target of rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells.
Topics: Adenosine Triphosphate; Animals; Autophagy; Bucladesine; Cell Count; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Knockdown Techniques; Humans; Isoquinolines; Mice; Microtubule-Associated Proteins; Phosphorylation; Sirolimus; Sulfonamides; TOR Serine-Threonine Kinases | 2010 |
Enhanced sensitivity to rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Cell Line, Tumor; Cell Proliferation; Chromones; Culture Media; Dose-Response Relationship, Drug; Estrogens; Flavonoids; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2011 |
Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus.
Topics: Adrenergic beta-Agonists; Animals; Bicuculline; Biophysics; Dose-Response Relationship, Drug; Electric Stimulation; Emetine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Flavonoids; Fragile X Mental Retardation Protein; GABA-A Receptor Antagonists; Hippocampus; Immunosuppressive Agents; In Vitro Techniques; Isoproterenol; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Pyridines; rap GTP-Binding Proteins; Sirolimus; Time Factors | 2011 |
mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; Endocrine Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastrointestinal Tract; Gene Expression Regulation; Humans; MAP Kinase Signaling System; Mechanistic Target of Rapamycin Complex 1; Mitogen-Activated Protein Kinases; Multiprotein Complexes; Naphthyridines; Neurotensin; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-jun; Regulatory-Associated Protein of mTOR; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2011 |
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Head and Neck Neoplasms; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Quinazolines; Signal Transduction; Sirolimus; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Tyrphostins | 2011 |
Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells.
Topics: Apoptosis; bcl-Associated Death Protein; Cell Line, Tumor; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Lung Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitination | 2012 |
TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori.
Topics: Animals; Bombyx; Butadienes; Ecdysteroids; Flavonoids; Gene Expression; Insect Hormones; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; HEK293 Cells; Humans; Iodine Radioisotopes; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; RNA, Messenger; Sirolimus; Symporters; Thyroid Gland; Thyrotropin; TOR Serine-Threonine Kinases | 2012 |
Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.
Topics: Adult; Aged; Androstadienes; Animals; Biological Transport; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Flavonoids; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Humans; Insulin; Male; Mice; Mice, Knockout; Middle Aged; Molecular Targeted Therapy; Muscle Cells; Muscle, Skeletal; Obesity; Peptides; Receptors, Bombesin; Sirolimus; Wortmannin | 2013 |
Increased expression of the antiapoptotic protein MCL1 in canine mast cell tumors.
Topics: Animals; Benzamides; Chromones; Dog Diseases; Dogs; Electrophoresis, Polyacrylamide Gel; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Imatinib Mesylate; Janus Kinases; Mastocytoma; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Piperazines; Pyrimidines; Sirolimus; Tyrphostins | 2013 |
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Chromones; ErbB Receptors; Female; Flavonoids; Hair Follicle; Hyperplasia; Keratinocytes; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred ICR; Mice, Transgenic; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2014 |
The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Butadienes; Cell Line, Tumor; Chloroquine; Cyclin D1; Drug Synergism; Everolimus; Flavonoids; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Membrane Proteins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Nitriles; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway.
Topics: Cell Line; Flavonoids; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratinocytes; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Phosphatidylinositol 3-Kinases; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2014 |
Effects of the mTOR inhibitor rapamycin on monocyte-secreted chemokines.
Topics: Anthracenes; Cell Line; Cell Survival; Chemokines; Flavonoids; Humans; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins | 2014 |
The TORC1/P70S6K and TORC1/4EBP1 signaling pathways have a stronger contribution on skeletal muscle growth than MAPK/ERK in an early vertebrate: Differential involvement of the IGF system and atrogenes.
Topics: Animals; Eukaryotic Initiation Factors; Flatfishes; Flavonoids; Mechanistic Target of Rapamycin Complex 1; Mitogen-Activated Protein Kinase Kinases; Multiprotein Complexes; Muscle Development; Muscle, Skeletal; Protein Kinase Inhibitors; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Somatomedins; TOR Serine-Threonine Kinases | 2015 |
Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Flavonoids; Imidazoles; MAP Kinase Kinase Kinases; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cadmium; Cell Death; Cell Line, Tumor; Environmental Pollutants; Female; Flavonoids; Gene Silencing; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Microscopy, Fluorescence; Neurons; Okadaic Acid; Protein Phosphatase 2; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies.
Topics: Androstadienes; Animals; Carrier Proteins; Chromones; Citrulline; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Malnutrition; Mechanistic Target of Rapamycin Complex 1; Mitogen-Activated Protein Kinases; Morpholines; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2017 |
Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts.
Topics: Animals; Anthracenes; Becaplermin; Cell Line; Cell Movement; Flavonoids; HSP27 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyridines; Sirolimus | 2017 |