pd 98059 has been researched along with sb 203580 in 825 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 73 (8.85) | 18.2507 |
| 2000's | 580 (70.30) | 29.6817 |
| 2010's | 164 (19.88) | 24.3611 |
| 2020's | 8 (0.97) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Akao, Y; Fujita, Y; Hamada, N; Ito, M; Itoh, T; Kiso, Y; Kitagawa, Y; Nozawa, Y; Ono, Y; Tanaka, A; Tomimori, N | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Chang, J; Liu, XH; Sun, X; Yu, JM; Zhong, C | 1 |
| Chokchaisiri, R; Chuprajob, T; Lin, Y; Lu, X; Shen, X; Sornkaew, N; Suksamrarn, A; Wang, F; Wang, P; Wongkrajang, K; Yang, L; Yang, N; Zhang, G; Zhou, Z | 1 |
| Cohen, P; Cuenda, A; Gould, GW; Thomson, FJ | 1 |
| Bokemeyer, D; Dunn, MJ; Sorokin, A | 1 |
| Flynn, A; Proud, CG; Vries, RG | 1 |
| Klip, A; McCall, A; Taha, C; Tsakiridis, T | 1 |
| Cohen, P; Haavik, J; Thomas, G | 1 |
| Boudreau, M; Hwang, D; Jang, BC; Yu, G | 1 |
| Engel, K; Gaestel, M; Schultz, H | 1 |
| Boyd, D; Goepfert, H; Simon, C | 1 |
| Harb, S; Heesemann, J; Hornef, M; Köhler, S; Roggenkamp, A; Rouot, B; Ruckdeschel, K; Zumbihl, R | 1 |
| Baines, IA; Cooper, JA; Flynn, A; Proud, CG; Vries, RG; Wang, X; Waskiewicz, AJ; Webb, BL | 1 |
| Hong, S; Joe, EH; Jou, I; Jung, S; Pyo, H | 1 |
| Bode, JG; Häussinger, D; Peters-Regehr, T; Schliess, F | 1 |
| Caivano, M | 1 |
| Delling, M; Gercken, G; Marti, T; Radloff, M | 1 |
| Jaakkola, P; Jalkanen, M; Kauppi, T; Kontusaari, S; Määtä, A | 1 |
| Begum, N; Duddy, N; McCarthy, M; Ragolia, L; Rienzie, J | 1 |
| Bevan, N; Lee, MG; Marshall, FH; Rees, S; Scott, S; Shaw, PE | 1 |
| Bonventre, JV; Choukroun, G; Force, T; Hajjar, R; Kyriakis, JM; Rosenzweig, A | 1 |
| Börsch-Haubold, AG; Pasquet, S; Watson, SP | 1 |
| Moriguchi, T; Nishida, E; Sugawara, T; Takahama, Y | 1 |
| Chang, MD; Cheng, TJ; Hung, JJ; Lai, YK | 1 |
| Engelman, JA; Lisanti, MP; Scherer, PE | 1 |
| Dackiw, AP; Kapus, A; Levy, G; Lu, Z; Marshall, JC; McGilvray, ID; Rotstein, OD; Wei, AC | 1 |
| Miyazawa, K; Mori, A; Okudaira, H | 1 |
| Nagarkatti, DS; Sha'afi, RI | 1 |
| Garcia, J; Lemercier, B; Rawadi, G; Roman-Roman, S | 1 |
| Bracke, M; Coffer, PJ; Koenderman, L; Lammers, JW | 1 |
| Bhat, NR; Zhang, P | 1 |
| Camp, HS; Leff, T; Tafuri, SR | 1 |
| Ahonen, M; Eriksson, JE; Holmström, T; Kähäri, VM; Westermarck, J | 1 |
| Isenović, E; LaPointe, MC | 1 |
| He, Q; LaPointe, MC | 1 |
| Marshall, CJ; Rausch, O | 1 |
| Flory, E; Grosse-Wilde, A; Hoffmeyer, A; Kunz, M; Ludwig, S; Neufeld, B; Rapp, UR | 1 |
| Cohen, P; Cuenda, A | 1 |
| Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH | 1 |
| Antonicelli, F; Aubert, D; Bonhomme, A; Burlet, H; el'Btaouri, H; Gomez-Marin, JE; Guenounou, M; Haye, B; Pinon, JM; Valere, A; Villena, I | 1 |
| Chen, CC; Wang, JK | 1 |
| Ajizian, SJ; English, BK; Meals, EA | 1 |
| Danne, M; Dickerson, JA; Dixon, CL; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Jeong, GB; Kim, EG; Kim, SY; Lee, JY; Park, MK; Shin, EY | 1 |
| Ezekiel, UR; Heuertz, RM; Tricomi, SM; Webster, RO | 1 |
| Dokter, W; Müller, M; Tuyt, L; Vellenga, E; Wierenga, BJ | 1 |
| Hammermann, R; Häussinger, D; Warskulat, U | 1 |
| Ikeda, K; Kawada, N; Kuroki, T; Seki, S | 1 |
| Barnes, PJ; De Souza, PM; Giembycz, MA; Kankaanranta, H; Lindsay, MA; Salmon, M | 1 |
| Ito, H; Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Tanabe, K; Uematsu, T | 1 |
| Abe, M; Sato, Y; Tanaka, K | 1 |
| Coogan, AN; O'Connor, JJ; O'Neill, LA | 1 |
| Abdel-Latif, AA; Husain, S | 1 |
| Creanor, J; Flatman, PW | 1 |
| Matthews, JS; O'Neill, LA | 1 |
| Healy, E; Leonard, M; Ryan, MP; Schramek, H; Watson, AJ | 1 |
| Badwey, JA; Huang, R; Lian, JP; Robinson, D | 1 |
| Cao, X; Lim, CP | 1 |
| Castagné, V; Clarke, PG | 1 |
| Gores, GJ; Park, J; Patel, T; Tadlock, L | 1 |
| Alessandrini, A; Bonventre, JV; Moskowitz, MA; Namura, S | 1 |
| Koppal, T; Lukas, TJ; Mirzoeva, S; Petrova, TV; Van Eldik, LJ; Watterson, DM | 1 |
| Kozawa, O; Miwa, M; Tokuda, H; Uematsu, T | 1 |
| Imura, T; Kageyama, T; Kimura, J; Shimohama, S | 1 |
| Daniels, I; Fletcher, J; Haynes, AP | 1 |
| Keates, AC; Keates, S; Kelly, CP; Murray, PG; Peek, RM; Warny, M | 1 |
| Joe, E; Jou, I; Jung, S; Lee, SH; Pyo, H | 1 |
| Behrens, MM; Choi, DW; Gwag, BJ; Koh, JY; Strasser, U | 1 |
| Feng, GJ; Goodridge, HS; Harnett, MM; Higson, AP; Liew, FY; Nikolaev, AV; Wei, XQ | 1 |
| Birkenkamp, KU; Esselink, MT; Kruijer, W; Vellenga, E | 1 |
| Ezumi, Y; Hirai, K; Nishida, E; Takayama, H; Uchiyama, T | 1 |
| Carvalho, AP; Cruz, MT; Duarte, CB; Gonçalo, M; Lopes, MC | 1 |
| Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Bowden, GT; Chen, W | 1 |
| Fujita, Y; Hirasawa, N; Ohuchi, K; Sato, Y | 1 |
| Alessi, DR; Fahlman, R; Krook, A; Ryder, JW; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Gardner, DG; Liang, F; Lu, S | 1 |
| Begum, N; Ragolia, L | 1 |
| Bae, HR; Bae, KW; Kang, EK; Lee, SA; Park, HT; Park, JK | 1 |
| Hiller, G; Sundler, R | 1 |
| Bilney, A; Ferrante, A; Hii, CS; Huang, ZH; Murray, AW; Rathjen, DA; Stacey, K | 1 |
| Cruise, L; Fuller, G; Ho, LK; Morris, BJ; Veitch, K | 2 |
| Burns, CJ; Persaud, SJ; Squires, PE | 1 |
| Ito, H; Ito, T; Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Sakai, N; Tanabe, K; Uematsu, T | 1 |
| Gon, Y; Hashimoto, S; Horie, T; Kujime, K; Shimizu, K | 1 |
| Hirasawa, N; Kobayashi, Y; Murakami, A; Ohuchi, K; Oikawa, S; Shiraishi, M | 1 |
| Chentoufi, J; Honbo, N; Kacimi, R; Karliner, JS; Long, CS | 1 |
| Okajima, E; Thorgeirsson, UP | 1 |
| Bertoglio, J; Letourneur, M; Pierre, J; Wery-Zennaro, S; Zugaza, JL | 1 |
| Bansal, R; Baron, W; de Vries, H; Hoekstra, D; Metz, B | 1 |
| Finlay, D; Furlong, F; Healy, V; Keon, NK; Martin, F; O'Connell, FC | 1 |
| Feuerstein, GZ; Gu, JL; Kumar, S; Lee, JC; Ma, XL; Maleeff, B; Ohlstein, EH; Thomas, H; Wang, C; Yue, TL | 1 |
| Adam, LP; Carty, M; Gerthoffer, WT; Hedges, JC; Oxhorn, BC; Yamboliev, IA | 1 |
| Aller, P; de Blas, E; Galán, A; García-Bermejo, ML; Kazanietz, MG; Troyano, A; Vilaboa, NE | 1 |
| Sha'afi, RI; Tandon, R; Thrall, RS | 1 |
| Hazan-Halevy, I; Levy, R; Seger, R | 1 |
| Akkerman, JW; Gorter, G; van Willigen, G | 1 |
| Abe, M; Ito, M; Kanno, S; Oda, N; Sato, Y; Shibuya, M; Shitara, K; Tabayashi, K; Terai, Y | 1 |
| Ayala, A; Chaudry, IH; Chung, CS; Song, GY | 1 |
| Adam, LP; Gerthoffer, WT; Hedges, JC; Mutnick, JL; Yamboliev, IA | 1 |
| Hashimoto, N; Hattori, I; Moriguchi, T; Nishida, E; Nozaki, K; Sugino, T; Takagi, Y | 1 |
| Cochet, C; Fahmi, H; Hmama, Z; Joab, I; Opolon, P | 1 |
| Hide, M; Koro, O; Okabe, T; Yamamoto, S | 1 |
| Matsumoto, M; Osada, H; Saito, T; Sudo, T; Tsujimoto, M | 1 |
| Armstrong, SC; Ganote, CE; Shivell, CL | 1 |
| Dickenson, JM; Germack, R | 1 |
| Bigg, HF; Cawston, TE; Clark, IM; McLeod, R; Waters, JG | 1 |
| Gerthoffer, WT; Hedges, JC; Singer, CA | 1 |
| Hatakeyama, D; Kawamura, H; Kozawa, O; Matsuno, H; Uematsu, T | 1 |
| Joe, E; Jou, I; Pyo, H; Ryu, J | 1 |
| Hazan-Halevy, I; Levy, R | 1 |
| Altura, BM; Altura, BT; Wang, J; Yang, ZW; Zheng, T | 1 |
| Babu, GJ; Lalli, MJ; Periasamy, M; Sadoshima, J; Sussman, MA | 1 |
| Han, SB; Jeon, YJ; Kim, HM; Kim, YK; Lee, M; Park, SM | 1 |
| Barnes, PJ; Cambridge, L; Hart, LA; Lindsay, MA; Newton, R; Stevens, DA | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Kawamura, H; Kozawa, O; Uematsu, T | 1 |
| Fahy, O; Hammad, H; Pestel, J; Sénéchal, S; Tonnel, AB; Tsicopoulos, A; Wallaert, B | 1 |
| Heads, RJ; Latchman, DS; Marber, MS; Mockridge, JW; Punn, A | 1 |
| Hide, I; Inoue, A; Inoue, K; Kohsaka, S; Nakajima, K; Nakata, Y; Tanaka, M | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CH; Luo, SF; Wang, CC; Yang, CM | 1 |
| Kinpara, K; Kondo, A; Mogi, M; Togari, A | 1 |
| Daimon, M; Hirata, A; Igarashi, M; Kato, T; Tominaga, M; Yamaguchi, H | 1 |
| Ishikawa, Y; Kitamura, M | 1 |
| Boucher, MJ; Lainé, J; Morisset, J; Reed, JC; Rivard, N; Vachon, PH | 1 |
| Ahn, HJ; Fujiwara, H; Hamaoka, T; Kurimoto, M; Nakahira, M; Ohta, T; Park, CS; Park, WR; Sugimoto, N | 1 |
| Eliazer, S; Ilaria, RL; Silvany, RE; Wolff, NC | 1 |
| Barchowsky, A; Frleta, D; Vincenti, MP | 1 |
| Fando, JL; Martín, ME; Muñoz, FM; Salinas, M | 1 |
| Arai, N; Araya, J; Fujita, T; Hayashi, R; Kashii, T; Kobayashi, M; Maruyama, M; Matsui, S; Sassa, K; Sugiyama, E; Yamashita, N; Yoshida, Y | 1 |
| Akamatsu, S; Dohi, S; Kozawa, O; Tanabe, K; Uematsu, T; Yamamoto, T | 1 |
| Kitamura, M; Konta, T; Lucio-Cazana, J; Moreno-Manzano, V; Nakayama, K | 1 |
| Blaine, S; Butterfield, L; Dessev, C; Han, SY; Heasley, LE; Nemenoff, RA; Refaat, Z; Wick, M | 1 |
| Dewas, C; El-Benna, J; Fay, M; Gougerot-Pocidalo, MA | 1 |
| Abdel-Latif, AA; Gao, G; Yousufzai, SY | 1 |
| Awasthi, V; King, RJ | 1 |
| Beck, KF; Eberhardt, W; Huwiler, A; Pfeilschifter, J; Walpen, S | 1 |
| Boos, MD; Chini, CC; Dick, CJ; Leibson, PJ; Schoon, RA | 1 |
| Elisei, R; Fagin, JA; Hara, T; Knauf, JA; Saavedra, HI; Shirokawa, JM; Wang, J | 1 |
| Bai, W; Jiang, F; Lee, H; Nicosia, SV; Su, B; Wang, Q; Yang, J | 1 |
| Hazzalin, CA; Mahadevan, LC; Rutault, K | 1 |
| Arcuri, C; Bocchini, V; Castigli, E; Gianfranceschi, GL; Giovagnoli, L; Luciani, R; Secca, T | 1 |
| Barnes, PJ; Giembycz, MA; Ito, K; Lindsay, MA; Meja, KK; Nasuhara, Y; Seldon, PM | 1 |
| Baron, P; Castranova, V; Jones, W; Martinez, A; Robinson, VA; Shi, X; Ye, J; Young, SH; Zeidler, P | 1 |
| Azuma, N; Chen, EL; Gahtan, V; Ikeda, M; Kito, H; Nakajima, N; Sumpio, BE; Wang, X | 1 |
| Ammon, HP; Bertsche, T; Boden, SE; Safayhi, H | 1 |
| Chen, CC; Chen, JJ; Chou, CY | 1 |
| Andersson, K; Sundler, R | 1 |
| Maruyama, M; Matsumoto, M; Osada, H; Sudo, T; Tsujimoto, M | 1 |
| Kristof, AS; Marks-Konczalik, J; Moss, J | 1 |
| Choe, ES; McGinty, JF | 1 |
| Brown, EM; Chattopadhyay, N; Kifor, O; Sanders, JL; Yamaguchi, T | 1 |
| Kozawa, O; Tokuda, H; Uematsu, T | 1 |
| Lee, J; Mira-Arbibe, L; Ulevitch, RJ | 1 |
| Amberger, J; Göbel, UB; Michelsen, KS; Opitz, B; Pfeil, D; Schröder, NW; Schumann, RR; Zähringer, U | 1 |
| Chen, CS; Dods, P; Gagnon, A; Roustan-Delatour, N; Sorisky, A | 1 |
| Hasegawa, T; Hato, F; Hino, M; Kitagawa, S; Sakamoto, C; Suzuki, K; Tatsumi, N; Zhou, YM | 1 |
| Kleijn, M; Morrice, NA; Proud, CG; Scheper, GC | 1 |
| Arimura, Y; Katagiri, T; Mitomo, K; Mizuno, K; Nebreda, AR; Ogimoto, M; Woodgett, JR; Yakura, H | 1 |
| Andreka, P; Bishopric, NH; Dougherty, C; Slepak, TI; Webster, KA; Zang, J | 1 |
| Chang, YJ; Chen, CC; Chen, JJ; Sun, YT | 1 |
| Almeida, IC; Closel, M; Cohen, P; Ferguson, MA; Gazzinelli, RT; Ropert, C; Travassos, LR | 1 |
| Gon, Y; Hashimoto, S; Horie, T; Maruoka, S; Matsumoto, K; Takeshita, I | 1 |
| Arrighi, JF; Hauser, C; Kindler, V; Rebsamen, M; Rousset, F | 1 |
| Hirata , K; Inoue, N; Kawashima, S; Kojima, Y; Rikitake, Y; Shimokawa, Y; Takeuchi, S; Yokoyama, M | 1 |
| Grant, S; Vrana, JA | 1 |
| Benito, M; Porras, A; Roncero, C; Valladares, A | 1 |
| Fennelly, C; Krause, D; Lyons, A; O'Connor, R | 1 |
| Arai, H; Ashida, N; Kita, T; Yamasaki, M | 1 |
| Aucoin, S; Diaz-Mitoma, F; Gee, K; Kozlowski, M; Kumar, A; Lim, W; Ma, W; Nandan, D | 1 |
| Gonzalez, A; Schmid, A; Schulz, I; Siegel, G; Sternfeld, L | 1 |
| Hirota, K; Semenza, GL | 1 |
| Linch, DC; Mollapour, E; Roberts, PJ | 1 |
| Akiyama, M; Fukunaga, K; Miyamoto, E; Moriya, T; Shibata, S; Yamamoto, M; Yokota , S | 1 |
| Lee, JK; Suh, HW; Won, JS | 1 |
| Bacus, SS; Gudkov, AV; Keyomarsi, K; Komarov, AP; Lowe, M; Lyass, L; Seger, R; Yarden, Y; Yung, Y | 1 |
| Delannoy, P; Lemonnier, J; Lomri, A; Marie, PJ | 1 |
| Callery, MP; Elbirt, KK; Potter, MW; Shah, SA | 1 |
| Fryer, RM; Gross, GJ; Hsu, AK | 1 |
| Harada, T; Morooka, T; Nishida, E; Ogawa, S | 1 |
| Hirasawa, N; Murakami, A; Ohuchi, K | 1 |
| Atfi, A; Baron, R; Faucheu, C; Gallea, S; Huet, L; Kawai, S; Lallemand, F; Ramez, V; Rawadi, G; Roman-Roman, S; Spinella-Jaegle, S | 1 |
| Fujii, S; Ichiki, T; Iino, N; Kitabatake, A; Shimokawa, H; Takeda, K; Takeshita, A; Tokunou, T | 1 |
| Buridi, A; Coxon, PY; Kettritz, R; Klein, JB; Manning, T; McLeish, KR; Rane, MJ | 1 |
| Lee, JC; Saldeen, J; Welsh, N | 1 |
| Choi, MR; Suh, HW; Won, JS | 1 |
| Bogoyevitch, MA; Long, CS; Ng, DC | 1 |
| Chen, KY; Chiu, SL; Hsu, HY; Hua, KF; Wen, MH | 1 |
| Inaguma, Y; Ito, H; Iwamoto, I; Kamei, K; Kato, K | 1 |
| Adrian, TE; Ding, XZ | 1 |
| Asano, T; Iida, KT; Kawakami, Y; Okuda, Y; Shimano, H; Sone, H; Suzuki, S; Toyoshima, H; Yamada, N | 1 |
| Fong, WF; Lam, W; Leung, CH; Wong, NS; Yang, MS; Zhuang, WJ | 1 |
| Banno, Y; Ito, Y; Izumi, T; Nakashima, S; Nozawa, Y; Shimizu, T; Wang, S | 1 |
| Baba, A; Hashimoto, H; Hirose, M; Ichibori, A; Sakai, Y; Shintani, N; Tanaka, K; Tomimoto, S | 1 |
| Brinckerhoff, CE; Vincenti, MP | 1 |
| Jeon, YJ; Kim, HM | 1 |
| Hatakeyama, D; Ito, H; Kato, K; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Bobrovskaya, L; Dunkley, PR; Leal, RB; Odell, A | 1 |
| Brancho, DM; Bulseco, DA; Parada, LF; Ross, AH; Schonhoff, CM | 1 |
| Byers, DM; Cook, HW; Ridgway, ND; Sunohara, JR | 1 |
| Créminon, C; Eligini, S; Habib, A; Lebret, M; Lévy-Toledano, S; Maclouf, J | 1 |
| Asakura, M; Asanuma, H; Fukushima, T; Hori, M; Kitakaze, M; Kuzuya, T; Liao, Y; Mori, H; Node, K; Ogai, A; Ogita, H; Papst, PJ; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S; Terada, N; Yamada, J | 1 |
| Dobashi, K; Ichimonji, I; Iizuka, K; Ishiwara, M; Ishizuka, T; Kawata, T; Mori, M; Nakazawa, T; Okajima, F; Tsukagoshi, H | 1 |
| Bankey, P; Friel, J; Nolan, B; Sheth, K | 1 |
| Akamatsu, S; Dohi, S; Kozawa, O; Matsuno, H; Tanabe, K; Uematsu, T; Yamamoto, T | 1 |
| Hallsworth, MP; Hirst, SJ; Lai, D; Moir, LM | 1 |
| Inaguma, Y; Ito, H; Iwamoto, I; Kato, K; Lida, K | 1 |
| Brune, K; Hinz, B; Pahl, A; Ramer, R | 1 |
| Blumenthal, A; Ehlers, S; Ernst, M; Flad, HD; Reiling, N | 2 |
| Ammit, AJ; Amrani, Y; Panettieri, RA | 1 |
| Choi, HS; Han, JY; Jeong, JS; Kim, IH; Park, JI | 1 |
| Beitner-Johnson, D; Kim, HW; Kim, R; Millhorn, DE; Seta, KA | 1 |
| Klein, JP; Neff, L; Schöller-Guinard, M; Sibilia, J; Wachsmann, D; Zeisel, M | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Lynch, OT | 1 |
| Aggeli, IK; Beis, I; Gaitanaki, C; Lazou, A | 1 |
| Romio, L; Varesio, L | 1 |
| Jung, HC; Kim, JM; Kim, JS; Song, IS | 1 |
| Chen, BC; Lin, WW | 1 |
| Cha, S; Hur, J; Kim, H; Kim, SY; Lee, MS; Suk, K | 1 |
| Cho, CH; Fan, XM; Kung, HF; Lam, SK; Lin, MC; Wang, WP; Wong, BC | 1 |
| Bang, OS; Chun, JS; Ju, JW; Kang, SS; Kim, JH; Kim, SJ; Oh, CD; Song, WK; Yoo, YJ; Yoon, YM | 1 |
| Chung, HT; Kim, NY; Kim, YM; Lee, HS; Oh, GS; Oh, H; Pae, HO; Shin, MK; Yun, YG | 1 |
| Slomiany, A; Slomiany, BL | 5 |
| Brunelleschi, S; Colangelo, D; Gaudino, G; Lavagno, L; Penengo, L; Santoro, C; Viano, I | 1 |
| Nihei, H; Nitta, K; Ohashi, T; Suzuki, H; Uchida, K; Yumura, W | 1 |
| Hattori, T; Nakanishi, T; Nishida, T; Takano-Yamamoto, T; Takigawa, M; Yosimichi, G | 1 |
| Kucera, GL; Stadheim, TA | 1 |
| Inanami, O; Ito, S; Karino, T; Kuwabara, M; Niwa, K; Ohta, T | 1 |
| Deb, DK; Platanias, LC; Sassano, A; Uddin, S; Varga, J; Verma, A; Wickrema, A | 1 |
| Grijalva, R; Klos, K; Li, P; Nguyen, N; Xiong, S; Yao, J; Yu, D | 1 |
| Kalsi, KK; Kochan, Z; Lawson, C; McCormack, A; Smolenski, RT; Yacoub, MH | 1 |
| Kandolf, R; Küpper, JH; Meyer, RG; Rodemann, HP | 1 |
| Gilmont, RR; Hirano, S; Rees, RS | 1 |
| Binétruy, B; Bost, F; Caron, L; Dani, C; Le Marchand-Brustel, Y; Marchetti, I | 1 |
| Ertl, G; Jacobs, M; Scheuren, N; Schorb, W | 1 |
| Hatakeyama, D; Kozawa, O; Uematsu, T | 1 |
| Avkiran, M; Hearse, DJ; Snabaitis, AK | 1 |
| Kerkelä, R; Majalahti-Palviainen, T; Pikkarainen, S; Ruskoaho, H; Tokola, H | 1 |
| Graf, D; Häussinger, D; Schliess, F; vom Dahl, S | 1 |
| Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Tokuda, H; Uematsu, T | 1 |
| Arena, S; Benatti, U; Corsaro, A; Damonte, G; Florio, T; Millo, E; Schettini, G; Tagliavini, F; Thellung, S; Villa, V | 1 |
| Christoffersen, T; Hege Thoresen, G; Nilssen, LS; Sandnes, D | 1 |
| Basdra, EK; Kletsas, D; Papavassiliou, AG | 1 |
| Betti, M; Canesi, L; Ciacci, C; Citterio, B; Gallo, G; Pruzzo, C; Scarpato, A | 1 |
| Funakoshi, Y; Ichiki, T; Iino, N; Takeda, K; Takeshita, A; Tokuno, T | 1 |
| Bompadre, MB; Coso, OA; Fernández, GC; Gómez, S; Isturiz, MA; Palermo, MS; Rosa, FA; Rubel, C | 1 |
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| Chang, B; Chen, B; Du, SX; Guo, C; Huang, DY; Li, XD; Liu, DX; Liu, ZY; Wang, YG; Xu, JK | 1 |
| Ariyoshi, W; Hida, D; Knudson, CB; Knudson, W; Takahashi, N | 1 |
| Chen, SC; Chiou, SJ; Chuang, LY; Guh, JY; Hwang, CC; Ko, YM; Lin, TD | 1 |
| Dong, S; Wang, J | 1 |
| Chabot, JG; Quirion, R; Wang, Z | 1 |
| Chang, KC; Jun, MS; Kim, HJ; Kim, HS; Kim, YM; Kim, YS; Lee, JH; Lee, KR; Park, EJ | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Nakae, H; Ozaki, K | 1 |
| Fragoulis, A; Kweider, N; Pecks, U; Pufe, T; Rath, W; Rosen, C; Wruck, CJ | 1 |
| Harbrecht, BG; Nweze, I; Smith, JW; Zhang, B | 1 |
| Hong, IS; Hong, SH; Kim, BM; Lee, KH | 1 |
| Breidenstein, A; Compton, T; Reeves, MB | 1 |
| Jung, YD; Khoi, PN; Kim, NH; Park, JS | 1 |
| Chen, XM; Drescher, KM; Gong, AY; Hu, G; Li, X; Zhou, R | 1 |
| Chang, Y; Shi, L; Wu, X; Yang, Y; Yu, FS; Zhang, Y | 1 |
| Huang, H; Huang, J; Huang, K; Lan, T; Liu, P; Liu, W; Peng, J; Shen, X; Xie, X | 1 |
| Chang, JZ; Chen, HM; Deng, YT; Kuo, MY; Yang, WH | 1 |
| Cherla, RP; Lee, MS; Leyva-Illades, D; Tesh, VL | 1 |
| Li, Y; Liu, X; Ma, B; Malik, AB; Minshall, RD; Sun, B; Tang, H; Wang, G; Xu, J; Yang, T; Ye, RD; Zhao, Y | 1 |
| Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC | 1 |
| He, S; Kong, X; Liu, C; Song, W; Wei, J; Wei, W; Yang, H; Zhang, W | 1 |
| Han, Y; Lei, L; Lu, S; Luo, G; Ning, Q; Wang, S; Yuan, X; Zhang, F | 1 |
| Chao, X; Chen, T; Fei, Z; Jiang, X; Li, D; Li, S; Liu, W; Lu, G; Luo, P; Poon, W; Qu, Y; Zhang, L; Zhao, Y | 1 |
| Peng, B; Wei, H; Wu, Y; Xing, X; Yang, S; Zhan, N; Zhu, L | 1 |
| Finamore, E; Galdiero, M; Galdiero, S; Mansi, R; Morelli, G; Tesauro, D; Vitiello, M | 1 |
| Han, H; Lee, KS; Rong, W; Zhang, G | 1 |
| Beppu, M; Kato, T; Masuko, K; Murata, M; Nakamura, H; Yudoh, K | 1 |
| Cao, H; Gu, Y; Wu, Y; Yang, Y; Yin, J; Zhang, L; Zhang, Y; Zhao, X; Zhao, Z; Zhou, Y | 1 |
| Gao, GR; Lv, CG; Zhang, BL; Zhang, C; Zhang, XF; Zhang, ZL | 1 |
| Gan, Y; Kuang, D; Ni, J; She, T; Wang, G; Wang, X; Yue, J; Zhao, X | 1 |
| Kasahara, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Mizuno, T; Sakakibara, S; Tokuda, H | 1 |
| Radhika, A; Sudhakaran, PR | 1 |
| Deng, F; He, Y; Li, C; Li, X; Yang, X; Ye, G; Zhang, X; Zhou, L | 1 |
| Imamura, E; Magata, F; Miyamoto, A; Murayama, C; Shimizu, T | 1 |
| Chang, YC; Huang, FM; Kuan, YH; Lee, SS; Tsai, CH | 1 |
| Demirel, I; Mohlin, C; Persson, K; Säve, S; Svensson, L; Vumma, R | 1 |
| Deng, XL; Li, GR; Su, XL; Wang, Y; Zhao, LM | 1 |
| Fahmi, A; Heads, R; Jabr, R; Marber, M; Punn, A; Smart, N | 1 |
| Akutsu, M; Ito, K; Kawashima, M; Kishida, T; Kondoh, T; Ogura, N | 1 |
| Chen, X; Duan, L; He, T; Luo, J; Shi, Q; Tang, M; Wang, H; Weng, Y; Wu, R; Yang, X; Ye, L; Zhang, Y; Zhou, L | 1 |
| Ou, SJ; Quinn, TM; Rosenzweig, DH | 1 |
| Cheng, M; Li, M; Meng, W; She, T; Shi, C; Wang, B; Yu, L | 1 |
| Chang, WW; Chen, MC; Kuan, YD; Lai, CH; Lee, CH; Lin, ST; Liu, CF | 1 |
| Chen, X; Cheng, B; Ge, J; He, P; Lu, H; Qi, B; Zeng, Y; Zhai, W | 1 |
| Chang, HH; Chang, JZ; Deng, YT; Kuo, MY; Liu, CM; Yang, WH | 1 |
| Cui, B; Gao, X; Jiao, Y; Sun, W; Xia, Y; Zhao, Y | 1 |
| E, LL; Liang, L; Liu, H; Liu, N; Wang, DS; Yu, J; Zhou, W | 1 |
| Billiar, TR; Fan, J; Fan, L; Jiang, Y; Li, S; Li, Y; Liu, Z; Scott, MJ; Wang, J; Wilson, MA; Xiao, G | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Ozaki, K; Shindo, S | 1 |
| Hauser, PJ; Hurst, RE; Klumpp, DJ; Marentette, JO; McHowat, J; Rickard, A | 1 |
| Du, M; Gao, C; Li, Y; Liu, L; Shi, Y; Tang, Y; Xing, M; Xiong, T; Yao, P | 1 |
| Andrews, MA; Austin, M; Ibe, BO; Lazaro, M; Lustina, J; Raj, JU; Renteria, LS | 1 |
| He, DK; Li, W; Shao, YR; Shen, J; Yuan, Z | 1 |
| Kikuchi, H; Takagi, N; Toyoda, H; Yuan, B; Yuhara, E | 1 |
| Hou, DJ; Jin, PS; Li, PH; Li, Q; Li, XY; Tao, CB; Zhang, AJ | 1 |
| Chang, J; Jiang, X; Li, H; Lin, K; Lu, WW; Pan, H; Xia, L; Xu, Y; Zhang, Z | 1 |
| Jung, TY; Kim, JH; Kim, MG; Lee, S; Leem, KH; Lim, SC; Seo, J | 1 |
| Chen, XM; Day, ML; Huang, C; Pollock, CA; Poronnik, P | 1 |
| Bu, HQ; Chen, L; Cui, JH; Huang, H; Li, Y; Liu, DL; Wei, WT | 1 |
| Cho, SS; Im, HJ; Kim, CS; Kim, DK; Kim, JS; Kim, SG; Lee, SY; Moon, SM; Oh, JS; Park, MR; Yoon, G; You, JS | 1 |
| Chang, M; Chen, P; Li, Y; Sun, S; Weng, T; Zhang, B; Zhang, L; Zhang, S | 1 |
| Nemoto, E; Shimauchi, H; Suzuki, R | 1 |
| Anada, T; Ishiko-Uzuka, R; Nishikawa, R; Suzuki, O | 1 |
| Ha, KT; Kim, BJ; Kim, MC; Kim, SY; Lee, HJ; Lim, B; So, I | 1 |
| Jiang, J; Li, D; Li, W; Liu, W; Ma, Y; Qu, Z; Ruan, Q; Yan, D; Yang, L | 1 |
| Han, HD; Kang, TH; Kim, JH; Kim, K; Kim, SH; Kim, TW; Kumar, V; Lee, KM; Lee, YH; Ng, J; Noh, KH; Song, KH; Sonn, CH; Sood, AK; Yee, C | 1 |
| Li, X; Zhang, Y | 1 |
| Chiu, CC; Hour, TC; Hsu, SH; Hsu, WC; Hu, HT; Huang, AM; Kao, YT; Lin, CS; Lu, CY; Pu, YS | 1 |
| Inagaki, Y; Kido, J; Nagata, T; Nakajima, Y | 1 |
| Chen, C; Li, C; Shi, Q; Wang, J; Wang, L; Weng, Y; Xiang, X; Yang, X; Ye, G; Yu, X; Zhang, R | 1 |
| Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Mizutani, J; Nakakami, A; Otsuka, T; Tokuda, H; Yamamoto, N | 1 |
| Aoki, M; Hirose, E; Ishimaru, Y; Kawata, J; Matsmoto, T; Narahara, S; Ono, T; Sagara, K; Yamaguchi, Y | 1 |
| de Toledo, A; Hirano, E; Inoue, S; Miyazaki, H; Morinaga, T; Okita, Y | 1 |
| Bang, SI; Cheon, S; Cho, D; Jung, MK; Kim, D; Kim, HJ; Park, H; Song, SB; Yang, Y | 1 |
| Astashkin, EI; Grachev, SV; Novikova, AN; Orekhova, NS; Sokolova, IN; Vinokurov, MG; Yurinskaya, MM | 1 |
| Chauski, EI; Khaliulin, IG; Maslov, LN; Mukhomedzyanov, AV; Portnichenko, AG; Tsibulnikov, SY | 1 |
| Aziz, M; Chaung, WW; Corbo, LM; Matsuo, S; Wang, P; Yang, WL | 1 |
| Hu, Z; Li, R; Li, Y; Tian, J; Wang, C; Wang, Y; Zhou, X | 1 |
| Hirose, E; Ishimaru, Y; Narahara, S; Sakamoto, A; Sugiuchi, H; Yamaguchi, R; Yamaguchi, Y; Yamamoto, T | 1 |
| Burmina, YV; Chaikovskii, AV; Danilets, MG; Dygai, AM; Minakova, MY; Miroshnichenko, LA; Shults, EE; Simanina, EV; Stavrova, LA; Tolstikova, TG; Udut, EV; Udut, VV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Choi, S; Jiao, HY; Jun, JY; Kim, MW; Kim, SW; Lee, MJ; Na, J; Park, CG; Park, IK; Shin, DH; So, I | 1 |
| Koh, SA; Lee, KH | 2 |
| Ding, WY; Gao, LJ; Gu, PQ; Huang, R; Liu, Z; Luo, XH; Ruan, HJ; Zhao, W | 1 |
| Chen, J; Feng, J; Guo, R; He, J; Liu, C; Lu, Y; Zhang, W; Zhang, Y; Zhen, Y | 1 |
| Andoh, A; Bamba, S; Imaeda, H; Inatomi, O; Kitoh, K; Nishida, A; Shimizu, T; Shioya, M; Takahashi, K | 1 |
| Agafonov, VI; Burmina, YV; Chaikovskii, AV; Dygai, AM; Khrichkova, TY; Miroshnichenko, LA; Reikhart, DV; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Liu, L; Lu, S; Mandal, J; Molino, A; Roth, M; Stolz, D; Sun, Q; Tamm, M | 1 |
| Cheng, W; Wang, H; Zhu, Y | 1 |
| Boecker, A; Evers, D; Jonas, R; Keller, V; Pogatzki-Zahn, EM; Reichl, S; Segelcke, D; Wenk, M; Zahn, PK | 1 |
| Chen, C; Shi, L; Sun, X; Wang, B; Wang, L; Wang, X | 1 |
| Guo, L; Hu, M; Jiao, Y; Lei, C; Wang, J; Wang, Q; Xu, J; Yang, Y | 1 |
| Cao, L; Chen, X; Li, W; Ma, Q; Xiao, X | 1 |
| Bai, Y; Cao, N; Du, Y; Gong, Y; Liu, H; Lv, T; Wang, W; Zhang, S | 1 |
| Agafonov, VI; Chaikovskii, AV; Dygai, AM; Khrichkova, TY; Minakova, MY; Miroshnichenko, LA; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Collins, CM; Ellis, JA; Holaska, JM | 1 |
| Beitz, AJ; Kaang, BK; Kim, YH; Ko, HG; Kwon, SG; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Ahn, SC; Kim, KY; Kim, SH; Kim, YW; Ma, JY; Park, KI; Park, SG; Seo, YK; Yu, SN | 1 |
| Li, Y; Wang, Y; Yang, L; Yin, D | 1 |
| Liu, H; Ou, L; Sun, K; Wang, C; Wang, P; Wu, Z; Xiong, Y; Yang, L; Zhang, R; Zhu, X | 1 |
| Hu, R; Hu, X; Hu, Z; Huang, J; Jiang, W; Ren, Z; Wang, Z; Wu, H | 1 |
| Chang, P; Chen, GM; Cui, SY; Guo, ZH; Huang, Q; Liu, J; Liu, ZG; Yu, Y | 1 |
| Fujita, K; Kainuma, S; Kawabata, T; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Otsuka, T; Sakai, G; Tokuda, H; Yamamoto, N | 1 |
| Fujita, K; Kainuma, S; Kawabata, T; Kozawa, O; Matsushima-Nishiwaki, R; Otsuka, T; Sakai, G; Tokuda, H | 1 |
| Gao, J; Jiang, Y; Lu, W; Shi, Q; Su, M; Sun, B; Xu, Y; Yang, X; Zhang, Y | 1 |
| Chen, J; Dong, J; Fu, C; Guo, Z; Li, N; Liu, Y; Wang, R; Wang, S; Yang, J; Yuan, Y; Zhang, Y | 1 |
| Hamilton, BJ; Stan, RV; Tse, D | 1 |
| Agafonov, VI; Dygai, AM; Minakova, MY; Miroshnichenko, LA; Polyakova, TY; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Chen, C; Li, J; Tu, M; Wan, X; Wang, C; Wang, L; Wang, P; Wang, Z; Weng, J; Zheng, X; Zhou, X; Zhou, Z | 1 |
| Agafonov, VI; Miroshnichenko, LA; Polyakova, TY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Guan, Q; Ma, Q; Nan, Y; Wang, H; Zhong, Y | 1 |
| Chen, H; Chen, J; Fu, G; Han, H; Niu, T; Wu, W; Zhou, J | 1 |
| Liu, J; Pan, L; Tian, Y | 1 |
| Chaikovskii, AV; Miroshnichenko, LA; Polyakova, TY; Simanina, EV; Stavrova, LA; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Ding, Y; He, Y; Li, J; Li, X; Lu, Y; Qi, J; Sun, Y; Wang, W; Wang, Y; Wu, H; Xu, R; Zhu, Q; Zhu, Z | 1 |
| Fang, X; Hao, X; Li, J; Liao, R; Zhang, W; Zhong, J; Zhu, T | 1 |
| Churin, AA; Fomina, TI; Miroshnichenko, LA; Polyakova, TY; Simanina, EV; Stavrova, LA; Zhdanov, VV; Zyuz'kov, GN | 1 |
2 review(s) available for pd 98059 and sb 203580
| Article | Year |
|---|---|
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
[Study of drugs against neoplastic metastasis].
Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibitors; Fatty Alcohols; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Morpholines; Neoplasm Metastasis; Paclitaxel; Pyridines; Ribavirin; Signal Transduction; Sirolimus | 2006 |
823 other study(ies) available for pd 98059 and sb 203580
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.
Topics: Animals; Apoptosis; Dioxoles; Heme Oxygenase-1; Hydrogen Peroxide; Lignans; NF-E2-Related Factor 2; PC12 Cells; Rats; Seedlings; Sesamum | 2011 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells.
Topics: Animals; Cell Line; Dimerization; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Resveratrol; Signal Transduction; Stilbenes; Structure-Activity Relationship | 2013 |
Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Diarylheptanoids; Janus Kinase 2; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Sepsis; STAT3 Transcription Factor | 2022 |
The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells.
Topics: Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Insulin-Like Growth Factor I; Interleukin-1; KB Cells; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; p38 Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Pyridines; Signal Transduction; Stimulation, Chemical | 1995 |
Differential regulation of the dual-specificity protein-tyrosine phosphatases CL100, B23, and PAC1 in mesangial cells.
Topics: Animals; Anisomycin; Cell Cycle Proteins; Cell Line; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 2; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Imidazoles; Immediate-Early Proteins; Male; Nuclear Proteins; Nucleophosmin; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 1997 |
Signalling pathways which regulate eIF4E.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Humans; Imidazoles; Insulin; Peptide Initiation Factors; Phosphorylation; Pyridines; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Transfection | 1997 |
Glucose transporter expression in L6 muscle cells: regulation through insulin- and stress-activated pathways.
Topics: 2,4-Dinitrophenol; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypertonic Solutions; Imidazoles; Insulin; Kinetics; Mannitol; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Monosaccharide Transport Proteins; Muscle, Skeletal; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stress, Physiological; Uncoupling Agents | 1997 |
Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells.
Topics: Adrenal Glands; Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Chromaffin Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Serine; Tyrosine 3-Monooxygenase | 1997 |
Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages.
Topics: Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; I-kappa B Proteins; Imidazoles; Lactams, Macrocyclic; Lactones; Lipopolysaccharides; Macrolides; Macrophages; Mice; Mitogens; NF-kappa B; NF-KappaB Inhibitor alpha; Prostaglandin-Endoperoxide Synthases; Pyridines; Quinones; Rifabutin; RNA, Messenger; Signal Transduction | 1997 |
PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Substrate Specificity; Tetradecanoylphorbol Acetate | 1997 |
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Collagenases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Head and Neck Neoplasms; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.
Topics: Animals; Apoptosis; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Leupeptins; Lipopolysaccharides; Macrophages, Peritoneal; Mice; NF-kappa B; Pyridines; Serotyping; Suppression, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha; Yersinia enterocolitica | 1998 |
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways.
Topics: Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cells, Cultured; CHO Cells; Cricetinae; Cytokines; Endothelium, Vascular; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Humans; Hydrogen Peroxide; Imidazoles; Intracellular Signaling Peptides and Proteins; Kidney; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Signal Transduction; Sorbitol; Stress, Physiological; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia.
Topics: Amyloid beta-Peptides; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Flavonoids; Imidazoles; Isoenzymes; Lipopolysaccharides; Microglia; Mitogens; Pyridines; Rats; Rats, Sprague-Dawley; Salmonella enteritidis; Tumor Necrosis Factor-alpha | 1998 |
Activation of mitogen-activated protein kinases and IL-6 release in response to lipopolysaccharides in Kupffer cells is modulated by anisoosmolarity.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hypertonic Solutions; Hypotonic Solutions; Imidazoles; Interleukin-6; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osmolar Concentration; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Time Factors; Transcription, Genetic | 1998 |
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Enzyme Activation; Flavonoids; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction | 1998 |
Hsp27 phosphorylation is induced in alveolar macrophages exposed to CdO-coated silica particles.
Topics: Animals; Cadmium Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Electrophoresis, Gel, Two-Dimensional; Flavonoids; Heat-Shock Proteins; Hydrogen Peroxide; Imidazoles; Macrophages, Alveolar; Oxides; Phosphoproteins; Phosphorylation; Pyridines; Quartz; Signal Transduction; Silicon Dioxide; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.
Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Movement; Enhancer Elements, Genetic; Enzyme Inhibitors; Epithelium; Fibroblast Growth Factors; Flavonoids; Gene Expression Regulation; Genistein; Imidazoles; In Vitro Techniques; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteoglycans; Pyridines; Receptors, Growth Factor; Skin Physiological Phenomena; Suramin; Syndecan-1; Syndecans; Transcriptional Activation; Wound Healing | 1998 |
Regulation of mitogen-activated protein kinase phosphatase-1 induction by insulin in vascular smooth muscle cells. Evaluation of the role of the nitric oxide signaling pathway and potential defects in hypertension.
Topics: Androstadienes; Animals; Cell Cycle Proteins; Cells, Cultured; Cyclic GMP; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Flavonoids; Imidazoles; Immediate-Early Proteins; Insulin; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Signal Transduction; Wortmannin | 1998 |
Nociception activates Elk-1 and Sap1a following expression of the ORL1 receptor in Chinese hamster ovary cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cyclic AMP; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; ets-Domain Protein Elk-4; Flavonoids; Genes, Reporter; Humans; Imidazoles; Narcotic Antagonists; Nociceptin Receptor; Nociceptors; Proto-Oncogene Proteins; Pyridines; Receptor Protein-Tyrosine Kinases; Receptors, Opioid; Transcription Factors; Transducin; Up-Regulation | 1998 |
Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.
Topics: Adenoviridae; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genetic Vectors; Heart; Imidazoles; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Cardiovascular; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; Recombinant Proteins; Signal Transduction; Transfection | 1998 |
Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Isoenzymes; Membrane Proteins; Platelet Activation; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Pyridines; Thromboxane A2; Thromboxane-A Synthase | 1998 |
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.
Topics: Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Transfer Techniques; Humans; Imidazoles; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Retroviridae; Signal Transduction; T-Lymphocytes | 1998 |
Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Cadmium Chloride; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Imidazoles; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Transcription Factors; Tumor Cells, Cultured | 1998 |
Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; Sequence Alignment; Transcription Factors | 1998 |
Murine hepatitis virus strain 3 induces the macrophage prothrombinase fgl-2 through p38 mitogen-activated protein kinase activation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Induction; Enzyme Inhibitors; Female; Fibrinogen; Flavonoids; Gene Expression Regulation; Imidazoles; Kinetics; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Murine hepatitis virus; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Thromboplastin | 1998 |
Establishment and characterization of a novel human rheumatoid fibroblast-like synoviocyte line, MH7A, immortalized with SV40 T antigen.
Topics: Antigens, Polyomavirus Transforming; Antigens, Surface; Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Dexamethasone; Fibroblasts; Flavonoids; Growth Substances; Humans; Imidazoles; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Receptors, Interleukin-1; Synovial Membrane; Transfection | 1998 |
Role of p38 MAP kinase in myocardial stress.
Topics: Adenosine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Ischemic Preconditioning, Myocardial; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Tetradecanoylphorbol Acetate | 1998 |
A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; CHO Cells; Cricetinae; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopeptides; Lipopolysaccharides; Lipoproteins; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Mycoplasma fermentans; NF-kappa B; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Proteins; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 1998 |
Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; Immunoglobulin A; Immunoglobulin G; Interleukin-4; Interleukin-5; Microspheres; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Pyridines; Receptors, Fc; Receptors, IgG; Rosette Formation; Signal Transduction; Th2 Cells; Wortmannin | 1998 |
Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cell Line; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hydrogen Peroxide; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Oligodendroglia; Oxidants; Oxidative Stress; Protein Kinases; Pyridines; Signal Transduction | 1999 |
c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity.
Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcription, Genetic; Ultraviolet Rays | 1999 |
Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38.
Topics: 3T3 Cells; Adult; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cells, Cultured; Collagenases; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Matrix Metalloproteinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines | 1998 |
Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes.
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclooxygenase 2; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Heart; Heart Ventricles; Imidazoles; Interleukin-1; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription, Genetic | 1999 |
Interleukin-1beta regulation of the human brain natriuretic peptide promoter involves Ras-, Rac-, and p38 kinase-dependent pathways in cardiac myocytes.
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dactinomycin; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; GTPase-Activating Proteins; Heart; Heart Ventricles; Humans; Imidazoles; Interleukin-1; Luciferases; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinases; Myocardium; Natriuretic Peptide, Brain; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteins; Pyridines; ras GTPase-Activating Proteins; ras Proteins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Transcription, Genetic; Transfection | 1999 |
Cooperation of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Imidazoles; Interleukin-3; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; ras Proteins; Receptors, Granulocyte Colony-Stimulating Factor; Tyrosine | 1999 |
Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor alpha gene expression in T lymphocytes.
Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation; Humans; Imidazoles; Ionomycin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Muscle Development; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Ribosomal Protein S6 Kinases; Sirolimus | 1999 |
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Interferon-gamma signal transduction during parasite infection: modulation of MAP kinases in the infection of human monocyte cells (THP1) by Toxoplasma gondii.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Cytosol; Enzyme Inhibitors; Flavonoids; Host-Parasite Interactions; Humans; Imidazoles; Interferon-gamma; Monocytes; Phosphorylation; Pyridines; Signal Transduction; Toxoplasmosis | 1998 |
p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 1999 |
Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interf
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha | 1999 |
The mitogen-activated protein kinase p38 is necesssary for interleukin 1beta-induced monocyte chemoattractant protein 1 expression by human mesangial cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemokine CCL2; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Glomerular Mesangium; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger | 1999 |
H-Ras is a negative regulator of alpha3beta1 integrin expression in ECV304 endothelial cells.
Topics: Antibodies; Cell Line, Transformed; Cell Movement; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Endothelium; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, Dominant; Humans; Imidazoles; Integrin alpha3beta1; Integrins; Morpholines; Oncogene Protein p21(ras); Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Transfection; Up-Regulation | 1999 |
C-reactive protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement.
Topics: C-Reactive Protein; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Chemotaxis; Flavonoids; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Signal Transduction | 1999 |
Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.
Topics: ATP-Binding Cassette Transporters; Blotting, Northern; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interleukin-6; Leukotriene C4; Lipopolysaccharides; Monocytes; Multidrug Resistance-Associated Proteins; Phosphorylation; Propionates; Proto-Oncogene Proteins c-jun; Pyridines; Quinolines; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Stimulation, Chemical; Up-Regulation | 1999 |
Anisoosmotic regulation of the Nopp140 mRNA in H4IIE rat hepatoma cells and primary hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleolus; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Hypertonic Solutions; Imidazoles; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Transcription, Genetic; Water-Electrolyte Balance | 1999 |
Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; Bucladesine; Cell Cycle; Cell Division; Cells, Cultured; Chromones; Cyclin D1; Cyclin D2; Cyclin E; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Inhibitors; Flavonoids; G1 Phase; Imidazoles; Liver; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; S Phase; Thymidine; Tritium | 1999 |
SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils.
Topics: Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cyclooxygenase Inhibitors; Cytokines; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interleukin-5; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines | 1999 |
Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Imidazoles; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Pyridines; Rats; RNA, Messenger; Signal Transduction; Sphingosine; Virulence Factors, Bordetella | 1999 |
Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis.
Topics: Actins; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; Endothelium, Vascular; Fibroblast Growth Factor 2; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Vinculin | 1999 |
The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Calmodulin-Dependent Protein Kinases; Dentate Gyrus; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Flavonoids; Imidazoles; In Vitro Techniques; Indomethacin; Interleukin-1; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Perforant Pathway; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cats; Cells, Cultured; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Flavonoids; GTP-Binding Proteins; Imidazoles; Indoles; Intercellular Signaling Peptides and Proteins; Iris; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peptides; Pertussis Toxin; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Receptors, Endothelin; Virulence Factors, Bordetella; Wasp Venoms | 1999 |
Stimulation of Na+-K+-2Cl- cotransport by arsenite in ferret erythrocytes.
Topics: Animals; Arsenites; Bumetanide; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Chlorides; Edetic Acid; Enzyme Inhibitors; Erythrocytes; Ferrets; Flavonoids; Genistein; Homeostasis; Imidazoles; In Vitro Techniques; Models, Biological; Potassium; Pyridines; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine | 1999 |
Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Humans; Imidazoles; Interleukin-1; Interleukin-2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured | 1999 |
Role of MAP kinase pathways in mediating IL-6 production in human primary mesangial and proximal tubular cells.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glomerular Mesangium; Humans; Imidazoles; Interleukin-6; Kidney Tubules, Proximal; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tumor Necrosis Factor-alpha | 1999 |
Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Guinea Pigs; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Renaturation; Pyridines; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa | 1999 |
Serine phosphorylation and negative regulation of Stat3 by JNK.
Topics: Amino Acid Substitution; Animals; COS Cells; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Point Mutation; Pyridines; Recombinant Fusion Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transfection; Ultraviolet Rays | 1999 |
Inhibitors of mitogen-activated protein kinases protect axotomized developing neurons.
Topics: Animals; Axotomy; Cell Death; Chick Embryo; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Pyridines; Retinal Ganglion Cells; Superior Colliculi | 1999 |
Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line.
Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Interleukin-6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pyridines; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.
Topics: Animals; Body Temperature Regulation; Brain Ischemia; Cardiovascular System; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunohistochemistry; Male; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Respiration | 1999 |
Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets.
Topics: Amidines; Animals; Benzylamines; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Drug Design; Enzyme Inhibitors; Flavonoids; Imidazoles; Indole Alkaloids; Isoquinolines; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Pyridines; Staurosporine; Sulfonamides | 1999 |
Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C.
Topics: Animals; Animals, Newborn; Bridged-Ring Compounds; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Interleukin-1; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Norbornanes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones | 1999 |
Selective induction of glial glutamate transporter GLT-1 by hypertonic stress in C6 glioma cells.
Topics: Alkaloids; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Benzophenanthridines; Biological Transport; Carrier Proteins; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Flavonoids; Gene Expression Regulation, Neoplastic; Glioma; Glutamate Plasma Membrane Transport Proteins; Hypertonic Solutions; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Phenanthridines; Phosphorylation; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Symporters; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Role of p38 in the priming of human neutrophils by peritoneal dialysis effluent.
Topics: Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; In Vitro Techniques; Kidney Failure, Chronic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peritoneal Dialysis; Phospholipases A; Phosphoric Diester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Superoxides | 1999 |
Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori.
Topics: Antigens, Bacterial; Bacterial Proteins; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gastric Mucosa; Helicobacter pylori; Humans; I-kappa B Proteins; Imidazoles; Interleukin-8; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Pyridines; Tumor Cells, Cultured; Up-Regulation | 1999 |
Gangliosides activate cultured rat brain microglia.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Brain; Culture Techniques; Cyclooxygenase 2; Enzyme Inhibitors; Flavonoids; Gangliosides; Imidazoles; Isoenzymes; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; Mitogen-Activated Protein Kinases; Neuraminidase; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.
Topics: Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phorbol Esters; Protein Kinase C; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macr
Topics: Animals; Cell Line; DNA-Binding Proteins; Enzyme Activation; Enzyme Induction; Flavonoids; Glycosphingolipids; Imidazoles; Interferons; Interleukin-12; JNK Mitogen-Activated Protein Kinases; Leishmania; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Signal Transduction; Transcription Factors | 1999 |
Differential effects of interleukin-3 and interleukin-1 on the proliferation and interleukin-6 protein secretion of acute myeloid leukemic cells; the involvement of ERK, p38 and STAT5.
Topics: Acute Disease; Cell Division; DNA; DNA-Binding Proteins; Flavonoids; Humans; I-kappa B Proteins; Imidazoles; Interleukin-1; Interleukin-3; Interleukin-6; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; MAP Kinase Signaling System; Milk Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured | 1999 |
Comparative study of vanadate- and phorbol ester-induced cyclo-oxygenase-2 expression in human endothelial cells.
Topics: Cyclooxygenase 2; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1999 |
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Dendritic Cells; Enzyme Inhibitors; Fetus; Flavonoids; Fluorescent Antibody Technique; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Imidazoles; Interleukin-1; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Skin; Tumor Necrosis Factor-alpha; Tyrphostins | 1999 |
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine | 1999 |
Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes.
Topics: Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, fos; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Keratinocytes; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Transcription, Genetic; Ultraviolet Rays | 1999 |
Involvement of a phosphatidylinositol 3-kinase-p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells.
Topics: Activating Transcription Factor 2; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP Response Element-Binding Protein; Dinitrophenols; Enzyme Activation; Flavonoids; Imidazoles; Interleukin-4; Mast Cells; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Serum Albumin; Transcription Factors; Wortmannin | 2000 |
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.
Topics: 3-O-Methylglucose; Amino Acid Sequence; Animals; Biological Transport; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Glycogen; Imidazoles; In Vitro Techniques; Indoles; Insulin; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphopeptides; Phosphorylation; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate | 2000 |
Endothelin-dependent and -independent components of strain-activated brain natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen-activated protein kinase.
Topics: Animals; Animals, Newborn; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Extracellular Space; Flavonoids; Gene Expression Regulation, Enzymologic; Heart Ventricles; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Mutagenesis; Myocardium; Natriuretic Peptide, Brain; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Rats; Stress, Mechanical; Transcription, Genetic; Transfection | 2000 |
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.
Topics: Animals; Aorta; Cell Cycle Proteins; Cell Division; Cells, Cultured; Dual Specificity Phosphatase 1; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Gene Expression Regulation, Enzymologic; Glucose; Hypoglycemic Agents; Imidazoles; Immediate-Early Proteins; Insulin; Insulin Resistance; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; Rats, Inbred WKY; RNA, Messenger | 2000 |
Calmodulin-dependent activation of p38 and p42/44 mitogen-activated protein kinases contributes to c-fos expression by calcium in PC12 cells: modulation by nitric oxide.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Potassium Chloride; Proto-Oncogene Proteins c-fos; Pyridines; Quinoxalines; Rats; Sulfonamides | 2000 |
Activation of arachidonate release and cytosolic phospholipase A2 via extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in macrophages stimulated by bacteria or zymosan.
Topics: Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Isoenzymes; Macrophages, Peritoneal; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Prevotella intermedia; Protein Processing, Post-Translational; Pyridines; Zymosan | 1999 |
Involvement of protein kinase C, p38 MAP kinase and ERK in arachidonic acid-stimulated superoxide production in human neutrophils.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Superoxides | 1999 |
Kainate receptors activate NF-kappaB via MAP kinase in striatal neurones.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcimycin; Calcium; Cells, Cultured; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; Immunohistochemistry; In Vitro Techniques; Ionophores; Kainic Acid; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; NF-kappa B; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Transcription Factor RelA | 2000 |
Signaling through the p38 and p42/44 mitogen-activated families of protein kinases in pancreatic beta-cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Islets of Langerhans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats | 2000 |
p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells.
Topics: Animals; Aorta; Arginine Vasopressin; Cell Line; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Immunoassay; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Naphthalenes; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phospholipid Ethers; Phosphorylation; Protein Kinase C; Pyridines; RNA, Messenger; Tetradecanoylphorbol Acetate; Vasopressins | 2000 |
p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells.
Topics: Acetylcysteine; Bronchi; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; Chemokine CCL5; Cytokines; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Indoles; Influenza A virus; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2000 |
Participation of mitogen-activated protein kinase in thapsigargin- and TPA-induced histamine production in murine macrophage RAW 264.7 cells.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Histamine Release; Imidazoles; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Hypoxia differentially regulates stress proteins in cultured cardiomyocytes: role of the p38 stress-activated kinase signaling cascade, and relation to cytoprotection.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Cell Hypoxia; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Imidazoles; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Myocardium; Oxidative Phosphorylation; Phenanthridines; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Receptors, Estrogen; RNA, Messenger; Signal Transduction; Tyrphostins | 2000 |
Different regulation of vascular endothelial growth factor expression by the ERK and p38 kinase pathways in v-ras, v-raf, and v-myc transformed cells.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Cell Line; Cell Transformation, Neoplastic; Endothelial Growth Factors; Epithelial Cells; Flavonoids; Genes, myc; Genes, ras; Imidazoles; Liver; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Oncogene Proteins v-raf; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Retroviridae Proteins, Oncogenic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; cdc42 GTP-Binding Protein; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-4; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Receptors, Interleukin-4; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; STAT6 Transcription Factor; Trans-Activators; Transcription, Genetic | 2000 |
PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Pyridines; Pyrrolidinones; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stem Cells | 2000 |
MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Epithelial Cells; Extracellular Matrix; Female; Flavonoids; Imidazoles; Mammary Glands, Animal; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines | 2000 |
Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart.
Topics: Animals; Animals, Newborn; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart; Imidazoles; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Recovery of Function | 2000 |
Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Cells, Cultured; Dogs; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; In Vitro Techniques; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Pyridines; Receptors, Muscarinic; Signal Transduction; Trachea | 2000 |
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells.
Topics: Apoptosis; Cadmium; Calcium-Calmodulin-Dependent Protein Kinases; Caspases; Enzyme Activation; Flavonoids; Humans; Imidazoles; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Necrosis; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; U937 Cells | 2000 |
Neutrophil beta2-integrin upregulation is blocked by a p38 MAP kinase inhibitor.
Topics: Antigens, CD; CD18 Antigens; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Indoles; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha | 2000 |
The requirement of both extracellular regulated kinase and p38 mitogen-activated protein kinase for stimulation of cytosolic phospholipase A(2) activity by either FcgammaRIIA or FcgammaRIIIB in human neutrophils. A possible role for Pyk2 but not for the G
Topics: Antigens, CD; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinases; Models, Biological; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Binding; Pyridines; Receptors, IgG; Signal Transduction; Superoxides; Time Factors; Tyrosine; Zymosan | 2000 |
Thrombopoietin increases platelet sensitivity to alpha-thrombin via activation of the ERK2-cPLA2 pathway.
Topics: Animals; Blood Platelets; Carbazoles; Cattle; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Humans; Imidazoles; Indoles; Indomethacin; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Processing, Post-Translational; Pyridines; Serotonin; Serum Albumin, Bovine; Thrombin; Thrombopoietin; Thromboxane A2 | 2000 |
Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells.
Topics: 3T3 Cells; Actins; Animals; Antibodies, Monoclonal; Cell Line; Cell Movement; Cytoskeletal Proteins; DNA; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Indoles; Lymphokines; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors; Vinculin | 2000 |
Immune suppression in polymicrobial sepsis: differential regulation of Th1 and Th2 responses by p38 MAPK.
Topics: Animals; Bacterial Infections; Cell Division; Concanavalin A; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Immune Tolerance; Interferon-gamma; Interleukin-10; Interleukin-2; Male; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Spleen; Th1 Cells; Th2 Cells | 2000 |
Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway.
Topics: Animals; Calcium; Calmodulin-Binding Proteins; Consensus Sequence; Dogs; Endothelin-1; Enzyme Inhibitors; Female; Flavonoids; Heat-Shock Proteins; Imidazoles; In Vitro Techniques; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Artery; Pyridines; Vasoconstriction | 2000 |
Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus.
Topics: Animals; Dentate Gyrus; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gerbillinae; Hippocampus; Imidazoles; Ischemic Attack, Transient; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Nerve Fibers; p38 Mitogen-Activated Protein Kinases; Prosencephalon; Pyramidal Cells; Pyridines | 2000 |
Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway.
Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Imidazoles; Immediate-Early Proteins; Kinetics; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protein Kinase C; Pyridines; RNA, Messenger; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured; Viral Proteins | 2000 |
Substance P induces tumor necrosis factor-alpha release from human skin via mitogen-activated protein kinase.
Topics: Adult; Aged; Aged, 80 and over; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Histamine Release; Humans; Imidazoles; In Vitro Techniques; Male; Middle Aged; Mitogen-Activated Protein Kinases; Pyridines; Skin; Substance P; Tumor Necrosis Factor-alpha | 2000 |
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL).
Topics: Animals; Blotting, Western; Bone Marrow Cells; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophage Colony-Stimulating Factor; MAP Kinase Kinase 4; MAP Kinase Kinase 6; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors | 2000 |
Differential translocation or phosphorylation of alpha B crystallin cannot be detected in ischemically preconditioned rabbit cardiomyocytes.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Crystallins; Cytoskeleton; Cytosol; Enzyme Inhibitors; Flavonoids; Heart Ventricles; Hydrogen-Ion Concentration; Imidazoles; Immunoblotting; Ischemic Preconditioning, Myocardial; Isoelectric Focusing; Lens, Crystalline; Marine Toxins; Mitogen-Activated Protein Kinases; Myocardium; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Pyridines; Rabbits; Time Factors | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor.
Topics: Cells, Cultured; Cycloheximide; Drug Synergism; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; Pyridines; Receptors, Retinoic Acid; Retinoid X Receptors; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcription Factors; Tretinoin | 2000 |
Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes.
Topics: Anti-Inflammatory Agents; Bronchi; Cell Line; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger | 2000 |
Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase.
Topics: Animals; Endothelial Growth Factors; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Imidazoles; Lymphokines; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Protein Kinase C; Pyridines; Pyrrolidinones; Receptor, Endothelin A; Receptors, Endothelin; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B.
Topics: Acetylcysteine; Animals; Carbazoles; Cells, Cultured; Cerebral Cortex; Enzyme Induction; Flavonoids; Imidazoles; Indoles; Maleimides; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase C; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thrombin | 2000 |
Activation of cytosolic phospholipase A2 by opsonized zymosan in human neutrophils requires both ERK and p38 MAP-kinase.
Topics: Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Pyridines | 2000 |
Low [Mg(2+)](o) induces contraction of cerebral arteries: roles of tyrosine and mitogen-activated protein kinases.
Topics: Animals; Basilar Artery; Butadienes; Dogs; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; In Vitro Techniques; Magnesium; Magnesium Deficiency; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phosphopeptides; Protein-Tyrosine Kinases; Pyridines | 2000 |
Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Nucleus; Cells, Cultured; Cytosol; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Genes, Reporter; Imidazoles; MAP Kinase Kinase 1; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Nuclear Proteins; Phenylephrine; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Serum Response Factor; Time Factors; Transcription Factors; Transfection | 2000 |
Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages.
Topics: Animals; Cell Line; Cell Nucleus; Drug Interactions; Enzyme Activators; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Lactones; Lipopolysaccharides; Macrolides; Macrophages, Peritoneal; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; p38 Mitogen-Activated Protein Kinases; Protein Binding; Proto-Oncogene Proteins c-rel; Pyridines; Stimulation, Chemical | 2000 |
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
Topics: Arachidonic Acid; Butadienes; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Time Factors; Tumor Cells, Cultured | 2000 |
Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase.
Topics: Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hydrolysis; Imidazoles; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositols; Pyridines; Sphingosine; Tumor Necrosis Factor-alpha; Type C Phospholipases | 2000 |
Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: involvement of the map kinase pathway.
Topics: Antigens, Dermatophagoides; Cell Survival; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokines; Chemotaxis; Child, Preschool; Culture Media, Conditioned; Cytokines; Drug Synergism; Enzyme Inhibitors; Flavonoids; Glutathione; Glycoproteins; Humans; Hypersensitivity; Imidazoles; Interleukin-8; Leukocytes, Mononuclear; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; RNA, Messenger; Tumor Necrosis Factor-alpha; Vehicle Emissions | 2000 |
PKC-dependent delayed metabolic preconditioning is independent of transient MAPK activation.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media; Enzyme Inhibitors; Flavonoids; Heart; Hydrogen-Ion Concentration; Imidazoles; Ischemic Preconditioning, Myocardial; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley | 2000 |
Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Calcium; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Kinetics; MAP Kinase Kinase 1; Microglia; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Agonists; Pyridines; Rats; Receptors, Purinergic P2X7; Tumor Necrosis Factor-alpha | 2000 |
Lipopolysaccharide enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells.
Topics: Animals; Binding, Competitive; Bradykinin; Calcium; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Inositol Phosphates; Isoenzymes; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Pyridines; ras Proteins; Signal Transduction; Time Factors; Trachea; Tritium | 2000 |
Anti-apoptotic action of nerve growth factor in mouse osteoblastic cell line.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cytokines; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mice; Nerve Growth Factor; NF-kappa B; Osteoblasts; Pyridines; Pyrrolidines; Receptor, trkA; Receptor, trkB; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates | 2000 |
Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Insulin; Male; Maleimides; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Time Factors | 2000 |
Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.
Topics: Animals; Apoptosis; Cells, Cultured; Curcumin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Mutagenesis; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Quercetin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factor AP-1; Transfection | 2000 |
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells.
Topics: Apoptosis; bcl-X Protein; Carcinoma; Caspases; Cell Cycle; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Tumor Cells, Cultured | 2000 |
Differential effects of N-acetyl-l-cysteine on IL-2- vs IL-12-driven proliferation of a T cell clone: implications for distinct signalling pathways.
Topics: Acetylcysteine; Animals; Cell Division; Cell Line; Dexamethasone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Imidazoles; Interleukin-12; Interleukin-2; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Precipitin Tests; Pyridines; Recombinant Proteins; Signal Transduction; T-Lymphocytes | 2000 |
Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.
Topics: 3T3 Cells; Animals; Binding Sites; Bone Neoplasms; Butadienes; Cell Transformation, Neoplastic; Colony-Forming Units Assay; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Humans; Imidazoles; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Oncogene Proteins, Fusion; Protein Serine-Threonine Kinases; Proto-Oncogene Protein c-fli-1; Pyridines; RNA-Binding Protein EWS; Sarcoma, Ewing; Transcription Factors; Tumor Cells, Cultured | 2000 |
Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts.
Topics: Animals; Blotting, Western; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Fibroblasts; Flavonoids; Genes, Reporter; Imidazoles; Interleukin-1; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Pyridines; Rabbits; Signal Transduction; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells.
Topics: Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Survival; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Flavonoids; Glucose; Hypoxia; Imidazoles; Intracellular Signaling Peptides and Proteins; Ischemia; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Binding; Protein Synthesis Inhibitors; Pyridines; Rats; Sirolimus; Time Factors | 2000 |
Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms.
Topics: Blotting, Northern; Blotting, Western; Bradykinin; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Imidazoles; Interleukin-6; Interleukin-8; Lung; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction | 2000 |
Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase.
Topics: Aorta; Arginine Vasopressin; Cell Line; Enzyme Inhibitors; Flavonoids; Hydrolysis; Imidazoles; Lysophospholipids; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositols; Phosphorylation; Pyridines; Sodium Fluoride; Sphingosine; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 2000 |
Enhancement of TNF-alpha-induced apoptosis by immobilized arginine-glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism.
Topics: Animals; Apoptosis; Benzoquinones; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Genistein; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinases; Mutation; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rats; Rifabutin; Time Factors; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Induction of cytosolic phospholipase A2 by oncogenic Ras is mediated through the JNK and ERK pathways in rat epithelial cells.
Topics: Animals; Cyclooxygenase 2; Cytosol; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genes, ras; Genes, Reporter; I-kappa B Proteins; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Luciferases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Respiratory Mucosa; Transfection | 2001 |
The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils.
Topics: Butadienes; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Nitriles; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst | 2000 |
Mitogen-activated protein kinase inhibitors suppress prostaglandin F(2alpha)-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle.
Topics: Animals; Carbachol; Cats; Dinoprost; Enzyme Inhibitors; Flavonoids; Imidazoles; Iris; Miotics; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Oxytocics; Phosphorylation; Pyridines | 2000 |
PKC, p42/p44 MAPK, and p38 MAPK are required for HGF-induced proliferation of H441 cells.
Topics: Adenocarcinoma; Cell Division; Cell Membrane; Cytosol; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Indoles; Isoenzymes; Kinetics; Lung Neoplasms; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tumor Cells, Cultured | 2000 |
Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein ki
Topics: Adjuvants, Immunologic; Animals; Base Sequence; Binding Sites; Biological Transport; Cell Nucleus; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Amplification; Gene Expression Regulation; Glomerular Mesangium; Hydrolysis; I-kappa B Proteins; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Promoter Regions, Genetic; Pyridines; Rats; RNA, Messenger; Superoxides; Tissue Inhibitor of Metalloproteinase-1; Transcription Factor AP-1; Transcription Factor RelA | 2000 |
Regulation of p38 mitogen-activated protein kinase during NK cell activation.
Topics: Androstadienes; Antibody-Dependent Cell Cytotoxicity; Cytotoxicity, Immunologic; Enzyme Inhibitors; Enzyme Precursors; Flavonoids; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lymphocyte Activation; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Receptors, IgG; src-Family Kinases; Syk Kinase; Wortmannin | 2000 |
Conditional apoptosis induced by oncogenic ras in thyroid cells.
Topics: Animals; Apoptosis; Cell Division; Cell Line; Cyclic AMP; Doxycycline; Enzyme Inhibitors; Flavonoids; Genes, ras; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Rats; Signal Transduction; Thyroid Gland; Thyrotropin | 2000 |
MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells.
Topics: Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Pyridines; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts.
Topics: Cell Differentiation; Cells, Cultured; Flavonoids; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Lipopolysaccharide Receptors; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Pyridines; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Interleukin-1beta induces apoptosis in GL15 glioblastoma-derived human cell line.
Topics: Antigens, Polyomavirus Transforming; Apoptosis; Brain Neoplasms; Cytoskeleton; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Imidazoles; In Situ Nick-End Labeling; Interleukin-1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pyridines; Tumor Cells, Cultured; Vimentin | 2000 |
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism.
Topics: Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Lipopolysaccharides; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
Activation of mitogen-activated protein kinase p38 and extracellular signal-regulated kinase is involved in glass fiber-induced tumor necrosis factor-alpha production in macrophages.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Glass; Imidazoles; Macrophages, Alveolar; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Rats, Sprague-Dawley; Response Elements; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2001 |
Role of mitogen-activated protein kinases in pulmonary endothelial cells exposed to cyclic strain.
Topics: Animals; Cattle; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pulmonary Artery; Pyridines; Response Elements; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2000 |
MEK-1/2 inhibition prevents 5-lipoxygenase translocation in N-formylpeptide-challenged human neutrophils.
Topics: Arachidonate 5-Lipoxygenase; Butadienes; Calcimycin; Calcium; Cell-Free System; Enzyme Activation; Flavonoids; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Protein-Tyrosine Kinases; Pyridines | 2000 |
Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase,
Topics: Bridged-Ring Compounds; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Humans; I-kappa B Kinase; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Naphthalenes; NF-kappaB-Inducing Kinase; Norbornanes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Thiocarbamates; Thiones; Tyrphostins | 2000 |
Signalling to translational activation of tumour necrosis factor-alpha expression in human THP-1 cells.
Topics: Anisomycin; Blotting, Northern; Blotting, Western; Butadienes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Ionophores; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor.
Topics: Animals; Bone Marrow Cells; Carrier Proteins; Cell Differentiation; Cell Line; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Giant Cells; Imidazoles; Intracellular Signaling Peptides and Proteins; Macrophage Colony-Stimulating Factor; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Monocytes; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Solubility; Tumor Necrosis Factor-alpha | 2000 |
Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation.
Topics: Binding Sites; Flavonoids; Humans; Imidazoles; Interferon-gamma; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Transcription Factor AP-1; Tumor Cells, Cultured | 2001 |
N-Methyl-D-aspartate receptors and p38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and Elk-1 phosphorylation in the striatum.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neostriatum; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Tetrodotoxin; Thionucleotides; Transcription Factors | 2000 |
Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line.
Topics: 3T3 Cells; Animals; Calcium; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gadolinium; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neomycin; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Calcium-Sensing; Receptors, Cell Surface; Spermine | 2000 |
Basic fibroblast growth factor stimulates vascular endothelial growth factor release in osteoblasts: divergent regulation by p42/p44 mitogen-activated protein kinase and p38 mitogen-activated protein kinase.
Topics: Animals; Calcimycin; Calcium; Endothelial Growth Factors; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Imidazoles; In Vitro Techniques; Ionophores; Lymphokines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thapsigargin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Hypertonic Solutions; I-kappa B Kinase; Imidazoles; Inflammation; Insulin-Like Growth Factor I; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandins A; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Stress, Physiological; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunoblotting; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Pyridines; Teichoic Acids; Time Factors; Treponema; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Apoptosis; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sirolimus; Wortmannin | 2001 |
Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: role in decreased responsiveness to inflammatory cytokines.
Topics: Adult; Apoptosis; Caspases; Cell Adhesion; Cell Survival; Cells, Cultured; Cycloheximide; Cytokines; DNA Fragmentation; Dose-Response Relationship, Immunologic; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Hydrolysis; Imidazoles; Inflammation; Jurkat Cells; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines; Superoxides; Tumor Necrosis Factor-alpha | 2001 |
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutation; Peptide Initiation Factors; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Sequence Homology, Amino Acid; Signal Transduction | 2001 |
Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45.
Topics: Animals; Blotting, Western; Cell Line; Cell Lineage; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukocyte Common Antigens; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Antigen, B-Cell; Time Factors; Transfection | 2001 |
Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cyclic GMP; Cysteine Proteinase Inhibitors; DNA Fragmentation; DNA, Recombinant; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glutathione; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Nitric Oxide; Nitroso Compounds; Plasmids; Protein Serine-Threonine Kinases; Pyridines; S-Nitrosoglutathione; Transfection | 2001 |
Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.
Topics: Cell Nucleus; Ceramides; Cyclooxygenase 2; Drug Interactions; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; I-kappa B Kinase; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Pulmonary Alveoli; Pyridines; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasiti
Topics: Activating Transcription Factor 2; Animals; Cyclic AMP Response Element-Binding Protein; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycosylphosphatidylinositols; I-kappa B Proteins; Imidazoles; Immune Tolerance; Inflammation; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Macrophages; MAP Kinase Kinase 4; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mucins; NF-kappa B; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protozoan Proteins; Pyridines; Receptors, Cell Surface; Transcription Factors; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2001 |
Transforming growth Factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway.
Topics: Carbazoles; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lung; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscles; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Pyridines; Transforming Growth Factor beta | 2001 |
A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers.
Topics: Allergens; Antigens, CD; Benzalkonium Compounds; Cell Differentiation; Cells, Cultured; Cytokines; Dendritic Cells; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Down-Regulation; Endocytosis; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Irritants; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lymphocyte Activation; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinases; Nickel; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; RNA, Messenger; Sodium Dodecyl Sulfate; T-Lymphocytes; Tumor Necrosis Factor-alpha; Up-Regulation | 2001 |
Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine.
Topics: Activating Transcription Factor 1; Animals; Cattle; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Isoenzymes; Isoquinolines; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA, Messenger; Sulfonamides; Transcription Factors; Up-Regulation | 2001 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Carrier Proteins; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Nucleus; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Ion Channels; Membrane Proteins; Mitochondrial Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; Rats; RNA; Transcription Factors; Tumor Necrosis Factor-alpha; Uncoupling Protein 1 | 2001 |
Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol.
Topics: Anisomycin; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Cytoskeleton; Dicumarol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Insulin Receptor Substrate Proteins; Interleukin-3; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Pyridines; Receptor, IGF Type 1; Recombinant Proteins; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 2001 |
Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxis.
Topics: CD18 Antigens; Cell Adhesion; Cell Line; Chemokine CCL2; Chemotaxis, Leukocyte; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Imidazoles; Integrin beta1; Kinetics; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; rho GTP-Binding Proteins; Signal Transduction; Vascular Cell Adhesion Molecule-1 | 2001 |
The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages.
Topics: Arabidopsis Proteins; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epstein-Barr Virus Nuclear Antigens; Erythroid-Specific DNA-Binding Factors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Imidazoles; Interleukin-10; Lipopolysaccharide Receptors; Lipopolysaccharides; Luciferases; Macrophages; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Pyridines; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; YY1 Transcription Factor | 2001 |
Arachidonic acid modulates the spatiotemporal characteristics of agonist-evoked Ca2+ waves in mouse pancreatic acinar cells.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcium Signaling; Cells, Cultured; Cholecystokinin; Enzyme Inhibitors; Flavonoids; Imidazoles; Indomethacin; Kinetics; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Phosphorylation; Pyridines | 2001 |
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
Topics: Animals; Binding Sites; Cell Hypoxia; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Genistein; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mammals; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Pyridines; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosol
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Complement C5a; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Group VI Phospholipases A2; Humans; Imidazoles; Ionophores; Isoenzymes; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Organophosphonates; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 2001 |
Involvement of calcium-calmodulin protein kinase but not mitogen-activated protein kinase in light-induced phase delays and Per gene expression in the suprachiasmatic nucleus of the hamster.
Topics: Animals; Benzylamines; Blotting, Western; Butadienes; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Circadian Rhythm; Cricetinae; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Hybridization; Light; Male; MAP Kinase Signaling System; Mesocricetus; Mitogen-Activated Protein Kinase Kinases; Motor Activity; Nerve Tissue Proteins; Nitriles; Nuclear Proteins; Period Circadian Proteins; Pyridines; RNA, Messenger; Sulfonamides; Suprachiasmatic Nucleus; Transcription Factors | 2001 |
Forskolin inhibits expression of inducible nitric oxide synthase mRNA via inhibiting the mitogen activated protein kinase in C6 cells.
Topics: Animals; Colforsin; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glioma; Imidazoles; Isoquinolines; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; RNA, Messenger; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Corpus Striatum; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Wortmannin | 2001 |
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Carcinoma; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Female; Flavonoids; G2 Phase; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Protein Serine-Threonine Kinases; Pyridines; Rats; Receptor, ErbB-2; Retinoblastoma Protein; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Increased expression of protein kinase Calpha, interleukin-1alpha, and RhoA guanosine 5'-triphosphatase in osteoblasts expressing the Ser252Trp fibroblast growth factor 2 receptor Apert mutation: identification by analysis of complementary DNA microarray.
Topics: Acrocephalosyndactylia; Amino Acid Substitution; Cell Line, Transformed; DNA, Complementary; Enzyme Induction; Enzyme Inhibitors; Fetus; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1; Isoenzymes; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Naphthalenes; Oligonucleotide Array Sequence Analysis; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Point Mutation; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Pyridines; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; rhoA GTP-Binding Protein; Skull; Subtraction Technique | 2001 |
Endotoxin (LPS) stimulates 4E-BP1/PHAS-I phosphorylation in macrophages.
Topics: Animals; Carrier Proteins; Cell Line; Cells, Cultured; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Pyridines; Rats; Sirolimus | 2001 |
ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection.
Topics: Analgesics; Animals; Blood Pressure; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Rate; Imidazoles; Ischemic Preconditioning, Myocardial; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Quinolines; Rats; Rats, Wistar; Receptors, Opioid | 2001 |
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.
Topics: Animals; Animals, Newborn; Bacterial Outer Membrane Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Immediate-Early Proteins; Immunoblotting; Lipoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; Neurons; PC12 Cells; Phosphotransferases; Plasmids; Protein Binding; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors; Transfection | 2001 |
Expression of 74-kDa histidine decarboxylase protein in a macrophage-like cell line RAW 264.7 and inhibition by dexamethasone.
Topics: Animals; Catalysis; Cell Line; Dexamethasone; Enzyme Activation; Enzyme Induction; Flavonoids; Histamine; Histidine Decarboxylase; Imidazoles; Immunoblotting; Macrophages; Mice; Mitogen-Activated Protein Kinases; Pyridines; Thapsigargin | 2001 |
Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells.
Topics: Alkaline Phosphatase; Animals; Bone Development; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Cricetinae; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; MAP Kinase Kinase 3; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; RNA, Messenger; Stem Cells; Transforming Growth Factor beta | 2001 |
Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA Processing, Post-Transcriptional; RNA, Messenger; Up-Regulation | 2001 |
Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.
Topics: Androstadienes; Apoptosis; Chemotaxis, Leukocyte; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leukotriene B4; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Virulence Factors, Bordetella; Wortmannin | 2001 |
Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Cytokines; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Imidazoles; Interferon-gamma; Interleukin-1; Islets of Langerhans; Male; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tumor Necrosis Factor-alpha | 2001 |
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1 | 2001 |
A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte
Topics: Acute-Phase Proteins; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cell Nucleus; Cells, Cultured; Culture Media, Serum-Free; Cycloheximide; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; Heart; Heart Ventricles; Hypertrophy; Imidazoles; Interleukin-1; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Kinetics; Leukemia Inhibitory Factor; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Protein Transport; Pyridines; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Trans-Activators | 2001 |
Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways.
Topics: Androstadienes; Animals; Cell Adhesion Molecules; Cell Line; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Fucose; Gene Expression Regulation; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kinetics; Ligands; Lipoproteins, LDL; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polysaccharides; Pyridines; Receptors, Immunologic; Receptors, Scavenger; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
Regulation of the levels of small heat-shock proteins during differentiation of C2C12 cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line; Creatine Kinase; Creatine Kinase, MM Form; Crystallins; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Isoenzymes; Mice; Molecular Chaperones; Muscle, Skeletal; Neoplasm Proteins; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Sirolimus; Transcription Factors | 2001 |
MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1.
Topics: Cell Cycle; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Pyridines; Tumor Cells, Cultured | 2001 |
Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway.
Topics: Cell Line; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Insulin; Kinetics; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Protein Biosynthesis; Pyridines; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins | 2001 |
Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells.
Topics: Animals; COS Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phospholipase D; Pyridines; Rats | 2001 |
Involvement of p38 MAP kinase pathway in the synergistic activation of PACAP mRNA expression by NGF and PACAP in PC12h cells.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; Neuropeptides; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyridines; Rats; RNA, Messenger; Signal Transduction | 2001 |
The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Collagenases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction | 2001 |
Experimental evidences and signal transduction pathways involved in the activation of NF-kappa B/Rel by angelan in murine macrophages.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Cells, Cultured; Electrophoresis; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Polymyxin B; Polysaccharides; Pyridines; Signal Transduction; Transfection | 2001 |
Mechanism of prostaglandin D(2)-stimulated heat shock protein 27 induction in osteoblasts.
Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin D2; Pyridines; RNA, Messenger; Staurosporine | 2001 |
Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anisomycin; Antihypertensive Agents; Butadienes; Cattle; Chromaffin Cells; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Phosphoserine; Protein Synthesis Inhibitors; Pyridines; Receptors, Angiotensin; Time Factors; Tyrosine 3-Monooxygenase | 2001 |
The Ras-ERK pathway is required for the induction of neuronal nitric oxide synthase in differentiating PC12 cells.
Topics: Animals; Butadienes; Cell Differentiation; Culture Media, Serum-Free; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genetic Vectors; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitriles; PC12 Cells; Pyridines; ras Proteins; Rats | 2001 |
Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide.
Topics: Antioxidants; Benzoquinones; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Lipopolysaccharides; Membrane Proteins; Microglia; Myristoylated Alanine-Rich C Kinase Substrate; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Pyridines; Quinones; Rifabutin; Signal Transduction; src-Family Kinases; Thiocarbamates | 2001 |
Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production.
Topics: Blotting, Northern; Blotting, Western; Cell Line; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Molsidomine; Nitrates; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Flow Velocity; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cardiovascular Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dogs; Enzyme Inhibitors; Flavonoids; Hemodynamics; Imidazoles; Indoles; Isoquinolines; Maleimides; Milrinone; Mitogen-Activated Protein Kinases; Myocardial Infarction; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase Inhibitors; Protein Kinase C; Pyridines; Pyridones; Sulfonamides; Ventricular Fibrillation | 2001 |
Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase.
Topics: Androstadienes; Animals; Cell Movement; Cells, Cultured; Clone Cells; Dinitrophenols; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Haptens; Imidazoles; Immunization; Immunoglobulin E; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-kit; Pyridines; Receptors, IgE; rho-Associated Kinases; Serum Albumin; Wortmannin | 2001 |
Inhibition of p38 mitogen activated protein kinase increases lipopolysaccharide induced inhibition of apoptosis in neutrophils by activating extracellular signal-regulated kinase.
Topics: Adult; Apoptosis; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2001 |
Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells.
Topics: Animals; Aorta; Butadienes; Cell Line; Dose-Response Relationship, Drug; Endothelial Growth Factors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Butadienes; Cytokines; Drug Evaluation, Preclinical; Eosinophils; Female; Flavonoids; Humans; Imidazoles; Lung Diseases, Obstructive; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Up-Regulation | 2001 |
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.
Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; Flavonoids; Glioma; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osmotic Pressure; Oxidants; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Sorbitol; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity.
Topics: Adult; Antibodies, Monoclonal; Antibody Specificity; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-10; JNK Mitogen-Activated Protein Kinases; Lectins, C-Type; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophages; Mannose Receptor; Mannose-Binding Lectins; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mycobacterium avium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyridines; Receptors, Cell Surface; Tumor Necrosis Factor-alpha | 2001 |
Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases.
Topics: Antigens, CD; Bronchi; Cells, Cultured; Chemokine CCL5; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha | 2001 |
Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells.
Topics: Cell Differentiation; Flavonoids; Humans; Hydroxyurea; Imidazoles; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines | 2001 |
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Cell Cycle Proteins; Cell Nucleus; Cobalt; Deferoxamine; DNA, Complementary; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Flavonoids; Gene Library; Hypoxia; Imidazoles; Immediate-Early Proteins; Mitogen-Activated Protein Kinases; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphoprotein Phosphatases; Polymerase Chain Reaction; Potassium Chloride; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; RNA, Messenger; Signal Transduction; Time Factors; Up-Regulation | 2001 |
NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci.
Topics: Anti-Bacterial Agents; Apigenin; Arthritis, Rheumatoid; Bacterial Proteins; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-6; Interleukin-8; MAP Kinase Signaling System; Membrane Glycoproteins; NF-kappa B; Pyridines; Signal Transduction; Streptococcus; Sulfasalazine; Synovial Membrane | 2001 |
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin | 2001 |
Stimulation of multiple MAPK pathways by mechanical overload in the perfused amphibian heart.
Topics: Animals; Cell Fractionation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart; Imidazoles; Immunoblotting; Immunohistochemistry; In Vitro Techniques; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Perfusion; Phosphorylation; Pressure; Pyridines; Rana ridibunda; Stress, Mechanical | 2001 |
Regulation of taurine transport in murine macrophages.
Topics: Animals; Biological Transport; Cell Line; Drosophila Proteins; Enzyme Inhibitors; Flavonoids; Hypertonic Solutions; Imidazoles; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Pyridines; Receptors, Cell Surface; Taurine; Toll-Like Receptor 4; Toll-Like Receptors | 2001 |
Expression of cyclooxygenase-2 in human neutrophils activated by Helicobacter pylori water-soluble proteins: possible involvement of NF-kappaB and MAP kinase signaling pathway.
Topics: Bacterial Proteins; Cyclooxygenase 2; Enzyme Inhibitors; Flavonoids; Helicobacter pylori; Imidazoles; Isoenzymes; Mitogen-Activated Protein Kinase Kinases; Neutrophils; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Pyridines; Pyrrolidines; Signal Transduction; Thiocarbamates; Transcription, Genetic; Up-Regulation | 2001 |
PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation.
Topics: Animals; Benzylamines; Bridged-Ring Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; Indoles; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Mitogen-Activated Protein Kinases; NF-kappa B; Norbornanes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Receptors, Purinergic P2; Sulfonamides; Thapsigargin; Thiocarbamates; Thiones; Time Factors; Transcription Factor RelA; Uridine Triphosphate | 2001 |
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway.
Topics: Amino Acid Sequence; Animals; Astrocytes; Caspases; Caspases, Initiator; Cell Line; Cloning, Molecular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Interferon-gamma; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Tumor Necrosis Factor-alpha | 2001 |
Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways.
Topics: Adenocarcinoma; Blotting, Western; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2001 |
ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Differentiation; Cells, Cultured; Chondrocytes; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits; Signal Transduction; Tumor Suppressor Protein p53 | 2002 |
Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe.
Topics: Apoptosis; DNA Fragmentation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Monocytic, Acute; Mistletoe; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Plant Preparations; Plant Proteins; Pyridines; Ribosome Inactivating Proteins, Type 2; Signal Transduction; Tetradecanoylphorbol Acetate; Toxins, Biological; U937 Cells | 2001 |
Role of ERK and p38 mitogen-activated protein kinase cascades in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide.
Topics: Animals; Endothelin-1; Flavonoids; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Imidazoles; Lipopolysaccharides; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2001 |
Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.
Topics: Adult; Androstadienes; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Growth Substances; Hepatocyte Growth Factor; Humans; Imidazoles; Insecta; Macrophages; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Proto-Oncogene Proteins; Pyridines; Receptors, Drug; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Involvement of MAP kinase cascades in Smad7 transcriptional regulation.
Topics: Animals; Anisomycin; Base Sequence; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Pyridines; Rats; RNA, Messenger; Smad7 Protein; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta | 2001 |
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK).
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Chondrocytes; Connective Tissue Growth Factor; DNA; Flavonoids; Genes, Reporter; Growth Substances; Humans; Imidazoles; Immediate-Early Proteins; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Proteoglycans; Pyridines; Rabbits; Recombinant Proteins; Signal Transduction | 2001 |
c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells.
Topics: Anisomycin; Antineoplastic Agents; Apoptosis; Blotting, Western; DNA, Neoplasm; Flavonoids; HL-60 Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitoxantrone; p38 Mitogen-Activated Protein Kinases; Precipitin Tests; Protein Synthesis Inhibitors; Pyridines; Transfection | 2002 |
p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not.
Topics: Animals; Calcium; Calcium Signaling; Capillary Permeability; Cattle; Cells, Cultured; Chelating Agents; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines | 2001 |
Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis.
Topics: Antigens, CD34; Apoptosis; Catalytic Domain; Cell Cycle; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hematopoiesis; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Interferon-beta; Interferons; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Signal Transduction; Stem Cells; Time Factors; Transforming Growth Factor beta; Up-Regulation | 2002 |
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Topics: Breast Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Neoplasm Invasiveness; Neuregulin-1; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; RNA, Neoplasm; Signal Transduction; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
TNF-alpha reduces the activity of ecto-5'-nucleotidase in human endothelial cells.
Topics: 5'-Nucleotidase; Cells, Cultured; Endothelium, Vascular; Flavonoids; Humans; Imidazoles; Neomycin; Pyridines; Tumor Necrosis Factor-alpha; Type C Phospholipases | 2000 |
Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.
Topics: Androstadienes; Anisomycin; Blotting, Western; Colforsin; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Flavonoids; Glioma; Humans; Imidazoles; Immediate-Early Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Suramin; Transcription Factors; Wortmannin | 2002 |
MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction.
Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Skin; Stress, Mechanical; Wound Healing | 2002 |
Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage.
Topics: Adipocytes; Animals; Butadienes; Cell Lineage; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Myocardium; Neurons; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Binding; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tretinoin | 2002 |
Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction.
Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Egg Proteins; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Imidazoles; Immunoblotting; Immunoenzyme Techniques; Immunohistochemistry; Isoenzymes; Lactones; Macrophages; Membrane Glycoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Necrosis; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Sulfones; Time Factors; Vimentin; Zona Pellucida Glycoproteins | 2002 |
Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts.
Topics: Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2002 |
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins | 2002 |
Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.
Topics: Animals; Atrial Natriuretic Factor; Binding Sites; Cell Nucleus; COS Cells; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GATA4 Transcription Factor; Imidazoles; Immunoblotting; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Natriuretic Peptide, Brain; p38 Mitogen-Activated Protein Kinases; Plasmids; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Transcription Factors; Transfection | 2002 |
Role of p38(MAPK) in cell volume regulation of perfused rat liver.
Topics: Animals; Cell Size; Flavonoids; Hydrogen Peroxide; Hypotonic Solutions; Imidazoles; Liver; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Perfusion; Potassium; Potassium Channels; Pyridines; Rats; Rats, Wistar; Signal Transduction; tert-Butylhydroperoxide | 2001 |
Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.
Topics: Analysis of Variance; Animals; Butadienes; Calcium; Calcium Channel Blockers; Cell Line; Chelating Agents; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Gallic Acid; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Chaperones; Naphthalenes; Neoplasm Proteins; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Staurosporine; Stimulation, Chemical; Time Factors; Type C Phospholipases | 2002 |
p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Neuroblastoma; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Prion Diseases; Prions; Pyridines; Tumor Cells, Cultured | 2002 |
Differential role of MAP kinases in stimulation of hepatocyte growth by EGF and G-protein-coupled receptor agonists.
Topics: Angiotensin II; Animals; Cell Division; Dinoprost; DNA; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocytes; Heterotrimeric GTP-Binding Proteins; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Norepinephrine; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Vasopressins | 2002 |
Effect of protein kinase inhibitors on the stretch-elicited c-Fos and c-Jun up-regulation in human PDL osteoblast-like cells.
Topics: Amides; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; rho-Associated Kinases; Stress, Mechanical; Up-Regulation | 2002 |
Signaling pathways involved in the physiological response of mussel hemocytes to bacterial challenge: the role of stress-activated p38 MAP kinases.
Topics: Androstadienes; Animals; Bivalvia; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavonoids; Hemocytes; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Wortmannin | 2002 |
Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Flavonoids; Imidazoles; Muscle, Smooth, Vascular; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 2002 |
Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway.
Topics: Apoptosis; Benzoquinones; Cell Degranulation; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Imidazoles; Kinetics; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Solubility | 2002 |
Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases.
Topics: Animals; Blotting, Northern; Cell Line; Enzyme Activation; Flavonoids; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tretinoin; Up-Regulation | 2002 |
Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells.
Topics: Active Transport, Cell Nucleus; Alanine; Animals; Apoptosis; Aspartic Acid; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Cytochalasin D; Cytoplasm; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Heat-Shock Proteins; Hippocampus; Hot Temperature; HSP27 Heat-Shock Proteins; Imidazoles; Immunohistochemistry; Mitogen-Activated Protein Kinases; Models, Genetic; Mutation; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Propidium; Pyridines; Rats; Serine; Signal Transduction; Stem Cells; Temperature; Time Factors; Transfection | 2002 |
A role for MAP kinase in the antitumor activity of a nucleoside analog.
Topics: Antiviral Agents; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Colony-Forming Units Assay; Cytidine Deaminase; DNA-Directed DNA Polymerase; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Ganciclovir; Herpesvirus 1, Human; Humans; Imidazoles; Mitogen-Activated Protein Kinases; NAD; Nucleic Acid Synthesis Inhibitors; Poly(ADP-ribose) Polymerases; Pyridines; Thymidine Kinase; Tumor Cells, Cultured | 2002 |
An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells.
Topics: Blotting, Northern; Cell Division; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gelatin; Gene Expression Regulation, Neoplastic; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Melanoma; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; RNA, Neoplasm; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 2002 |
Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects.
Topics: Animals; Brain; Brain Injuries; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; In Vitro Techniques; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neurons; Pyridines; Rats | 2002 |
Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.
Topics: Animals; Carrier Proteins; Cell Line; Chromones; Curcumin; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation; Genes, Dominant; Imidazoles; Interleukin-1; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Naphthalenes; Oxygen; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyridines; rac1 GTP-Binding Protein; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection | 2002 |
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.
Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Inhibition of IL-8-mediated MAPK activation in human neutrophils by beta1 integrin ligands.
Topics: Antibodies, Monoclonal; Chemotaxis, Leukocyte; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Imidazoles; Integrin alpha5beta1; Integrin alpha6beta1; Integrin beta1; Interleukin-8; Laminin; Ligands; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neutrophils; Oligopeptides; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Recombinant Proteins | 2002 |
Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.
Topics: Adrenergic alpha-Agonists; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart; Imidazoles; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Ribosomal Protein S6 Kinases, 90-kDa | 2002 |
Erk 1/2 differentially regulates the expression from the 1G/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells.
Topics: Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Polymorphism, Genetic; Promoter Regions, Genetic; Pyridines; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Signaling pathways induced by lipoproteins derived from Mycoplasma salivarium and a synthetic lipopeptide (FSL-1) in normal human gingival fibroblasts.
Topics: Bacterial Proteins; Blotting, Western; Diglycerides; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gingiva; Humans; Imidazoles; Interleukin-6; Lipoproteins; Mycoplasma; NF-kappa B; Oligopeptides; Phosphorylation; Pyridines; Signal Transduction; Transcription Factor AP-1 | 2002 |
Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFalpha expression in human fetal astrocytes.
Topics: Astrocytes; Cells, Cultured; Enzyme Inhibitors; Fetus; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha | 2002 |
ERK MAP Kinase is required in 1,25(OH)2D3-induced differentiation in human osteoblasts.
Topics: Alkaline Phosphatase; Calcitriol; Calcium Channel Agonists; Cell Differentiation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Osteoblasts; Precipitin Tests; Pyridines | 2002 |
p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells.
Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Imidazoles; Interferon-gamma; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Mice; Microglia; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Time Factors | 2002 |
Disruption in gastric mucin synthesis by Helicobacter pylori lipopolysaccharide involves ERK and p38 mitogen-activated protein kinase participation.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gastric Mucosa; Helicobacter pylori; Imidazoles; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Mucins; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley | 2002 |
Immunomodulatory effect of oxygen and pressure.
Topics: Animals; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Inhibitors; Flavonoids; Hyperbaric Oxygenation; Imidazoles; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Oxygen; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha | 2002 |
Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study.
Topics: Aged; Animals; Antioxidants; Blotting, Western; Case-Control Studies; Cytokines; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Failure; Humans; Imidazoles; Interferon-gamma; Interleukin-1; Male; Mitogen-Activated Protein Kinase 6; Mitogen-Activated Protein Kinases; Muscle, Skeletal; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Proline; Pyridines; Rats; Signal Transduction; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Interferon-beta activates multiple signaling cascades in primary human microglia.
Topics: Cells, Cultured; Chemokines; Chemokines, CC; DNA-Binding Proteins; Enzyme Inhibitors; Fetus; Flavonoids; Gene Expression; Gene Expression Regulation; Humans; Imidazoles; Interferon-beta; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Pyridines; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription Factor AP-1; Transcription Factors | 2002 |
Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.
Topics: Antineoplastic Agents; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; Oligopeptides; Peptide Fragments; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Pyridines; Stress, Physiological; Tumor Necrosis Factor-alpha; Tyrphostins; Ultraviolet Rays | 2002 |
Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Culture Media, Conditioned; Cyclin D1; Cyclins; Enzyme Inhibitors; Flavonoids; Genes, ras; Imidazoles; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Pyridines; Rats; Recombinant Proteins; Transforming Growth Factor alpha | 2002 |
Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch.
Topics: Bronchi; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-8; Mitogen-Activated Protein Kinases; Models, Biological; Phosphorylation; Pyridines; Respiratory Mucosa; RNA, Messenger; Stress, Mechanical | 2002 |
Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases.
Topics: Antibodies; CD18 Antigens; Cell Adhesion; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Imidazoles; Inflammation; Integrin beta1; Mitogen-Activated Protein Kinases; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Pyridines; Thromboplastin; Tumor Necrosis Factor-alpha | 2002 |
Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction | 2002 |
Activation of extracellular signal-regulated kinases is essential for pressure-induced proliferation of vascular smooth muscle cells.
Topics: Animals; Cell Division; Cells, Cultured; Culture Media, Conditioned; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Phosphorylation; Pressure; Pyridines; Rats; Rats, Sprague-Dawley | 2002 |
IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components.
Topics: Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibronectins; Flavonoids; Humans; Hyaluronan Receptors; Hyaluronic Acid; Imidazoles; Integrin beta1; Interferon-gamma; Interleukin-12; Interleukin-18; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; T-Lymphocytes | 2002 |
High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells.
Topics: Collagen Type I; DNA; DNA-Binding Proteins; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Matrix Metalloproteinase 1; Melanoma; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Pyridines; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2002 |
A mitogen-activated protein kinase is involved in the inotropic but not chronotropic actions of adrenoceptor agonists and endothelin-1.
Topics: Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Analysis of Variance; Animals; Butadienes; Endothelin-1; Enzyme Inhibitors; Flavonoids; Heart Rate; Imidazoles; Isoproterenol; Male; MAP Kinase Signaling System; Methoxamine; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardial Contraction; Nitriles; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 2002 |
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin | 2002 |
Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
Topics: Arachidonic Acids; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprost; Dinoprostone; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-6; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Nitrobenzenes; Organophosphonates; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Tumor Cells, Cultured | 2002 |
Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization.
Topics: Albuterol; Basophils; Calcimycin; Calcium Channel Blockers; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Histamine Release; Humans; Imidazoles; Immunoglobulin E; Interleukin-13; Interleukin-4; Interleukins; Leukotriene C4; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Salmeterol Xinafoate; Second Messenger Systems; Theophylline | 2002 |
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Blotting, Western; Cell Division; Collagen Type I; Cyclic AMP Response Element-Binding Protein; Drug Synergism; Female; Fibroblasts; Fibronectins; Fibrosis; Flavonoids; Humans; Imidazoles; Luciferases; Myocardium; Nifedipine; Norepinephrine; Phosphorylation; Plasminogen Activator Inhibitor 1; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured | 2002 |
Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Curcumin; Dipeptides; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Humans; Imidazoles; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Oligodeoxyribonucleotides, Antisense; Promoter Regions, Genetic; Pyridines; ras Proteins; Recombinant Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured | 2002 |
Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways.
Topics: Cell Division; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interleukin-10; Kinetics; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mycobacterium avium; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha; Virulence | 2002 |
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Topics: Adenocarcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Chromosome Mapping; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Disease Progression; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2002 |
Dietary salt intake activates MAP kinases in the rat kidney.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Kidney; Kidney Glomerulus; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Sodium Chloride, Dietary; Tetraethylammonium; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Involvement of Elk-1 in L6E9 skeletal muscle differentiation.
Topics: Animals; Cell Differentiation; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Pyridines; Rats; Transcription Factors | 2002 |
Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway.
Topics: alpha-Synuclein; Animals; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Morpholines; Nerve Tissue Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; RNA, Messenger; Signal Transduction; Synucleins; Time Factors; Tumor Cells, Cultured | 2002 |
Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms.
Topics: Animals; Cecum; Chemokine CXCL2; Enzyme Inhibitors; Extravascular Lung Water; Flavonoids; Hemorrhage; Imidazoles; In Vitro Techniques; Interleukin-6; Lipopolysaccharides; Macrophages, Alveolar; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monokines; NF-kappa B; Peroxidase; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Shock, Septic; Tumor Necrosis Factor-alpha | 2002 |
Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury.
Topics: Animals; Aorta; Cells, Cultured; Enhancer Elements, Genetic; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Imidazoles; Lung Diseases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Mutagenesis; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pulmonary Artery; Pyridines; Rats; Reperfusion Injury; RNA, Messenger; Transcription, Genetic | 2002 |
Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.
Topics: Amidohydrolases; Antioxidants; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Imidazoles; In Vitro Techniques; Neutrophil Activation; Neutrophils; Pyridines; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.
Topics: Animals; Butadienes; Carrier Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; MAP Kinase Kinase Kinase 1; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Monocytes; Nitriles; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Time Factors | 2002 |
Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glycoproteins; Imidazoles; Mitogen-Activated Protein Kinases; Mucins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Sublingual Gland | 2002 |
Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible nitric oxide synthase activation by ERK and p38 kinase.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mucins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Porphyromonas gingivalis; Pyridines; Rats; Rats, Sprague-Dawley; Saliva; Up-Regulation | 2002 |
Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells.
Topics: Animals; Butadienes; Cells, Cultured; Curcumin; Enzyme Inhibitors; Female; Flavonoids; Gene Expression; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; Myometrium; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Uterine Contraction | 2002 |
Salicylate suppresses macrophage nitric-oxide synthase-2 and cyclo-oxygenase-2 expression by inhibiting CCAAT/enhancer-binding protein-beta binding via a common signaling pathway.
Topics: Animals; Blotting, Western; Cell Line; Chromones; Cyclooxygenase 2; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Interferon-gamma; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Morpholines; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nuclear Proteins; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Salicylates; Signal Transduction; Time Factors; Trans-Activators; Transfection | 2002 |
Kinetics of mitogen-activated protein kinase family in lipopolysaccharide-stimulated mouse Kupffer cells and their role in cytokine production.
Topics: Animals; Cytokines; Female; Flavonoids; Imidazoles; Inflammation; Interleukin-10; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sepsis; Tumor Necrosis Factor-alpha | 2002 |
Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity.
Topics: Animals; Antioxidants; Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2E1; DNA; Flavonoids; Hepatocytes; Humans; Imidazoles; Male; Metalloendopeptidases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Salicylates | 2003 |
Nuclear localisation of cytosolic phospholipase A2-alpha in the EA.hy.926 human endothelial cell line is proliferation dependent and modulated by phosphorylation.
Topics: Amino Acid Sequence; Cell Count; Cell Division; Cell Line; Cell Nucleus; Cytosol; Fatty Acids, Unsaturated; Flavonoids; Gene Expression Regulation, Enzymologic; Group IV Phospholipases A2; Humans; Imidazoles; Lectins; Models, Molecular; Molecular Sequence Data; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Conformation; Protein Transport; Pyridines; Staurosporine | 2002 |
Agonists of proteinase-activated receptor 2 induce TNF-alpha secretion from astrocytoma cells.
Topics: Astrocytoma; Blotting, Western; Calcium; Central Nervous System; Chymases; Cytokines; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptides; Polymerase Chain Reaction; Protein Structure, Tertiary; Pyridines; Receptor, PAR-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Time Factors; Trypsin; Trypsin Inhibitors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
The role of MAPK pathways in the action of chemotherapeutic drugs.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Cycle; Ceramides; Enzyme Activation; Enzyme Inhibitors; Etoposide; Female; Flavonoids; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Microtubules; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Paclitaxel; Pyridines; Skin Neoplasms; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2002 |
Involvement of NMDA receptors and a p21Ras-like guanosine triphosphatase in the constitutive activation of nuclear factor-kappa-B in cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alkyl and Aryl Transferases; Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Down-Regulation; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; GTP Phosphohydrolases; Imidazoles; Immunohistochemistry; Neurons; NF-kappa B; Nitroarginine; Oxadiazoles; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins p21(ras); Pyrazoles; Pyridines; Pyrimidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Transcription Factor RelA | 2002 |
CCL20/macrophage inflammatory protein-3alpha production in LPS-stimulated neutrophils is enhanced by the chemoattractant formyl-methionyl-leucyl-phenylalanine and IFN-gamma through independent mechanisms.
Topics: Chemokine CCL20; Chemokines, CC; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyridines; Receptors, CCR6; Receptors, Chemokine; Recombinant Proteins; RNA Stability; RNA, Messenger; Signal Transduction; Up-Regulation | 2002 |
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2002 |
Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats.
Topics: Acetaldehyde; Animals; Cells, Cultured; Cytochrome P-450 CYP2E1; Diet; Enzyme Inhibitors; Ethanol; Flavonoids; Imidazoles; Kupffer Cells; Male; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylcholines; Pyridines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2002 |
Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 through ERK 1/2 pathway in capillary endothelial cells.
Topics: Animals; Capillaries; Cattle; Endothelium, Vascular; Enzyme Activation; Flavonoids; Imidazoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Tetradecanoylphorbol Acetate | 2003 |
Antioxidants induce different phenotypes by a distinct modulation of signal transduction.
Topics: Antioxidants; Apoptosis; DNA-Binding Proteins; DNA, Complementary; Early Growth Response Protein 1; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Models, Chemical; Phenotype; Phenylethyl Alcohol; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyridines; Pyrrolidines; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stilbenes; Thiocarbamates; Time Factors; Transcription Factors; Up-Regulation | 2002 |
Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells.
Topics: Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; Imidazoles; Immunoassay; Immunoblotting; Indoles; Interleukin-1; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mucin-2; Mucins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors | 2002 |
IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4, MAP kinase inhibitors and redox state of HepG2 cells.
Topics: Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Interleukin-4; Interleukin-6; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Pyridines; Receptor Cross-Talk; Signal Transduction; STAT3 Transcription Factor; Trans-Activators | 2002 |
Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation.
Topics: Adipocytes; Androstadienes; Cell Differentiation; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leptin; Lipid Metabolism; Lipids; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rosiglitazone; Signal Transduction; Sirolimus; Stem Cells; Thiazoles; Thiazolidinediones; Tumor Necrosis Factor-alpha; Wortmannin | 2003 |
[Synergetic effect of mitogen-activated protein kinase pathway on expression of tumor necrosis factor alpha gene in RAW 264.7 cells induced by lipopolysaccharide].
Topics: Animals; Anthracenes; Blotting, Western; Cell Line; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Mutation; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2002 |
Degradation of alpha-actin filaments in venous smooth muscle cells in response to mechanical stretch.
Topics: Actin Cytoskeleton; Actins; Animals; Caspase 3; Caspases; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Venae Cavae | 2003 |
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression.
Topics: Androstadienes; Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle Proteins; Cell Division; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cyclin A; Cyclin D1; Cyclin E; DNA-Binding Proteins; Dose-Response Relationship, Drug; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; E2F3 Transcription Factor; Electrophoresis, Polyacrylamide Gel; Endothelial Growth Factors; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Proliferating Cell Nuclear Antigen; Pyridines; Signal Transduction; Time Factors; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2003 |
Nitric oxide as a modulator of gastric mucin synthesis: role of ERK and p38 mitogen-activated protein kinase activation.
Topics: Animals; Apoptosis; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gastric Mucosa; Imidazoles; Mitogen-Activated Protein Kinases; Mucins; Mucous Membrane; Nitric Oxide; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Biological Transport; Blotting, Western; Cartilage, Articular; Chondrocytes; Cytoplasm; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Activation; Female; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Pyridines; Rabbits; Signal Transduction; Time Factors | 2003 |
Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cells.
Topics: Arthritis, Rheumatoid; Carrier Proteins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Imidazoles; Integrin alpha4; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Pyridines; Synovial Membrane | 2003 |
Effects of transforming growth factor-[beta] and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells.
Topics: Administration, Topical; Anthracenes; Anti-Inflammatory Agents; Apoptosis; Bronchi; Budesonide; Caspase 3; Caspases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Glucocorticoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Transforming Growth Factor beta | 2003 |
p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene.
Topics: Antigens, CD; B7-2 Antigen; Cytokines; Dendritic Cells; Dinitrochlorobenzene; Enzyme Inhibitors; Flavonoids; Humans; I-kappa B Proteins; Imidazoles; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Nickel; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Pyridines; RNA, Messenger | 2003 |
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).
Topics: Animals; Butadienes; Cell Line; Cell Nucleus; Enzyme Inhibitors; Escherichia coli; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; NF-kappa B; Nitriles; Phosphorylation; Protein Subunits; Pyridines; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sulfonamides; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2003 |
Modulation of renal epithelial barrier function by mitogen-activated protein kinases (MAPKs): mechanism of cyclosporine A-induced increase in transepithelial resistance.
Topics: Animals; Biological Transport; Cell Line; Cyclosporine; Electric Impedance; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Imidazoles; Immunosuppressive Agents; Kidney; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2003 |
p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts.
Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cell Line; Chromones; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells.
Topics: Cells, Cultured; Coronary Vessels; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Lipoproteins, HDL; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Proto-Oncogene Proteins p21(ras); Pyridines | 2003 |
Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic adenosine 5'-monophosphate and growth factors.
Topics: Animals; Arsenites; Carcinogens; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Hepatocyte Growth Factor; Humans; Hypoglycemic Agents; Imidazoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sodium Compounds; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 2003 |
Type 2 deiodinase expression is stimulated by growth factors in human vascular smooth muscle cells.
Topics: Anthracenes; Cycloheximide; Dactinomycin; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-sis; Pyridines; RNA, Messenger | 2003 |
Involvement of mitogen-activated protein kinases in Group B Streptococcus-induced macrophage apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Enzyme Activation; Female; Flavonoids; Flow Cytometry; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophages, Peritoneal; Male; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Streptococcus agalactiae | 2003 |
Air pollution particles produce airway wall remodeling in rat tracheal explants.
Topics: Air Pollution; alpha-Fetoproteins; Animals; Cells, Cultured; Chelating Agents; Collagen; Deferoxamine; DNA, Complementary; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Expression Regulation; Hydroxyproline; Imidazoles; Iron; Mitogen-Activated Protein Kinases; NF-kappa B; Organ Culture Techniques; Oxidants; p38 Mitogen-Activated Protein Kinases; Peptides; Procollagen; Promoter Regions, Genetic; Pyridines; Rats; Thiourea; Time Factors; Trachea; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Mitogen-activated protein kinases partially regulate endothelin-1-induced contractions through a myosin light chain phosphorylation-independent pathway.
Topics: Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Endothelin-1; Flavonoids; Imidazoles; In Vitro Techniques; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Vasoconstriction | 2003 |
Correlation of mitogen-activated protein kinase activities with cell survival and apoptosis in porcine granulosa cells.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Female; Flavonoids; Follicle Stimulating Hormone; Granulosa Cells; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Ovary; Oxidants; Protein Serine-Threonine Kinases; Pyridines; Swine; Time Factors | 2003 |
p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades.
Topics: Animals; Blotting, Western; Cell Division; Cell Line; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epithelium; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Immunohistochemistry; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Time Factors; Wound Healing | 2003 |
Signaling pathways for TNFa-induced COX-2 expression: mediation through MAP kinases and NFkB, and inhibition by certain nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Densitometry; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Hypoxia; Imidazoles; Luciferases; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Plasmids; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Pyridines; Rats; Rats, Wistar; RNA; RNA, Messenger; Signal Transduction; Time Factors; Transcriptional Activation; Transfection | 2003 |
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.
Topics: Actins; Bacterial Proteins; Cell Adhesion; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophils; Pertussis Toxin; Pyridines; Superoxides | 2003 |
Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway.
Topics: Androstadienes; Animals; Antioxidants; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Platelet-Derived Growth Factor; Polyphenols; Protein Processing, Post-Translational; Pyridines; Rats; Reactive Oxygen Species; RNA, Messenger; Thrombin; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Wine; Wortmannin | 2003 |
Dominant negative c-Jun inhibits platelet-derived growth factor-directed migration by vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cell Movement; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Imidazoles; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2003 |
T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism.
Topics: Animals; Cells, Cultured; Collagenases; Culture Media, Conditioned; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; Matrix Metalloproteinase 13; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; Pyridines; Recombinant Proteins; T-Lymphocytes | 2003 |
Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neutrophils; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrrolidines; RNA, Messenger; Thiocarbamates; Time Factors; Tumor Necrosis Factor-alpha | 2003 |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin | 2003 |
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Drug Screening Assays, Antitumor; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Pyridines; Recombinant Proteins; Sulfonamides; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways.
Topics: Arteriosclerosis; Blotting, Western; Cell Adhesion; Cell Communication; Cells, Cultured; Coculture Techniques; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; Isoprostanes; Leukocytes; Mitogen-Activated Protein Kinases; Monocytes; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Signal Transduction; Time Factors | 2003 |
Inflammatory agonist stimulation and signal pathway of oxidative burst in neonatal chicken heterophils.
Topics: Animals; Animals, Newborn; Chickens; Enzyme Inhibitors; Flavonoids; Fluoresceins; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Neutrophils; Protein Kinase C; Pyridines; Respiratory Burst; Salmonella enteritidis; Signal Transduction; Staphylococcus aureus; Teichoic Acids; Tetradecanoylphorbol Acetate | 2003 |
TGF-beta1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production.
Topics: 3T3 Cells; Animals; Apoptosis; Cell Division; Ceramides; Culture Media; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Time Factors; Transforming Growth Factor beta | 2003 |
Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells.
Topics: Animals; Aorta; Cells, Cultured; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Imidazoles; Imines; Indoles; Interleukin-6; Isoquinolines; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Protein Kinase C; Pyridines; Rats; Sulfonamides; Urocortins | 2003 |
Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter.
Topics: Air Pollutants; Bronchi; Cells, Cultured; Chemokine CCL20; Chemokines, CC; Cytokines; Dendritic Cells; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Macrophage Inflammatory Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Particle Size; Pyridines; Receptors, CCR6; Receptors, Chemokine; Respiratory Mucosa; RNA, Messenger | 2003 |
Cytokine-suppressive anti-inflammatory drugs (CSAIDs) inhibit invasion and MMP-1 production of ovarian carcinoma cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Cytokines; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Inflammation; Interleukin-1; Laminin; MAP Kinase Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteoglycans; Pyridines; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB.
Topics: Animals; Cycloheximide; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein Synthesis Inhibitors; Pyridines; Rats; RNA, Messenger; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase.
Topics: Apoptosis; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Lysophospholipids; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Sphingosine | 2003 |
Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.
Topics: Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoenzymes; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyridines; Transcription Factors | 2003 |
MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.
Topics: Acetylcholine; Animals; Cats; Enzyme Inhibitors; Esophagogastric Junction; Esophagus; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Second Messenger Systems | 2003 |
Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts.
Topics: 3T3 Cells; Angiogenesis Inducing Agents; Animals; Butadienes; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Growth Factors; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; Pyridines; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Intraluminal pressure stimulates MAPK phosphorylation in arterioles: temporal dissociation from myogenic contractile response.
Topics: Adenosine; Animals; Arterioles; Cyclooxygenase Inhibitors; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Vasomotor System | 2003 |
Chronic regulation of the expression of the gap junction protein connexin 43 in transfected HeLa cells.
Topics: Adenylyl Cyclases; Blotting, Western; Colforsin; Connexin 43; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gap Junctions; Gene Expression Regulation; HeLa Cells; Humans; Imidazoles; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Tumor Necrosis Factor-alpha | 2003 |
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anthracenes; Carrier Proteins; Dimerization; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Hybrid Cells; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinases; Neurons; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Proteins; Pyridines; Rats; Signal Transduction | 2003 |
Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages.
Topics: Acetyltransferases; Adult; Chromatin; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Female; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Histone Acetyltransferases; Humans; Hydroxamic Acids; I-kappa B Proteins; Imidazoles; Lipopolysaccharides; Macrophages, Alveolar; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Pyridines | 2004 |
Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages.
Topics: Animals; CHO Cells; Cricetinae; Enzyme Activation; Flavonoids; Gene Expression; Glycosylphosphatidylinositols; I-kappa B Kinase; Imidazoles; Immune Tolerance; Interleukin-1 Receptor-Associated Kinases; Lipopolysaccharides; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Mucins; NF-kappa B; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Receptors, Cell Surface; Recombinant Proteins; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2003 |
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins | 2003 |
The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Heart Ventricles; Imidazoles; Leptin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Obesity; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Receptors, Cell Surface; Receptors, Leptin; RNA, Messenger | 2003 |
Cardiopulmonary bypass reduces peripheral microvascular contractile function by inhibition of mitogen-activated protein kinase activity.
Topics: Aged; Arterioles; Cardiopulmonary Bypass; Cell Cycle Proteins; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Female; Flavonoids; Humans; Imidazoles; Immediate-Early Proteins; Male; Microcirculation; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Tissue Distribution; Vasoconstriction | 2003 |
Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF, and G-CSF: the role of MAP kinases.
Topics: Actin Depolymerizing Factors; Actins; Adult; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Microfilament Proteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polymers; Pyridines; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2004 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.
Topics: Chemotaxis, Leukocyte; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Flavonoids; Humans; Imidazoles; Interleukin-8; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst; Signal Transduction; Superoxides | 2003 |
Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Line; Cells, Cultured; Electrophoretic Mobility Shift Assay; Enzyme Activation; Fibroblasts; Flavonoids; Gene Deletion; Glucose Transporter Type 1; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Myocytes, Cardiac; Protein Binding; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Transcription Factor AP-1; Transcription, Genetic | 2003 |
Growth hormone reduces chloride secretion in human colonic epithelial cells via EGF receptor and extracellular regulated kinase.
Topics: Biological Transport; Carbachol; Cell Line; Chlorides; Cholinergic Agonists; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Human Growth Hormone; Humans; Imidazoles; Intestinal Mucosa; Janus Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Tyrosine | 2003 |
Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro.
Topics: Animals; Anticonvulsants; Cyclopropanes; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Flavonoids; Glycine; Hippocampus; Imidazoles; In Vitro Techniques; Long-Term Potentiation; Male; Methoxyhydroxyphenylglycol; Neural Inhibition; Pyridines; Rats; Rats, Wistar; Synapses; Time Factors | 2003 |
Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Blotting, Western; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Flavonoids; Humans; Imidazoles; Indoles; Interleukin-1; Kinetics; Maleimides; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; NF-kappa B; Pancreas; Proline; Pyridines; Thiocarbamates; Tumor Necrosis Factor-alpha | 2003 |
Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cytoprotection; Dose-Response Relationship, Radiation; Enzyme Activation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Korea; Lysophospholipids; Melanocytes; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyridines; Sphingosine; Ultraviolet Rays | 2003 |
IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.
Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin | 2003 |
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins | 2003 |
Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells.
Topics: Acetylcysteine; Animals; Blotting, Western; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glutathione; Hydrogen Peroxide; Imidazoles; Lung; MAP Kinase Signaling System; Microcirculation; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Permeability; Pyridines; Reactive Oxygen Species; Time Factors | 2003 |
Growth factor-dependent activation of the MAPK pathway in human pancreatic cancer: MEK/ERK and p38 MAP kinase interaction in uPA synthesis.
Topics: Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2003 |
Are changes in MAPK/ERK necessary or sufficient for entrainment in chick pineal cells?
Topics: Acetylserotonin O-Methyltransferase; Animals; Blood Proteins; Caffeine; Cells, Cultured; Central Nervous System Stimulants; Chickens; Circadian Rhythm; Darkness; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Light; Melatonin; Mitogen-Activated Protein Kinases; Osmolar Concentration; Pineal Gland; Pyridines | 2003 |
Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Cytokines; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; Janus Kinase 1; Male; MAP Kinase Signaling System; Morpholines; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Biosynthesis; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Tyrphostins | 2003 |
Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways.
Topics: Colforsin; Cytokines; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Lipopolysaccharides; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Porins; Proto-Oncogene Proteins c-raf; Pyridines; RNA, Messenger; Salmonella typhimurium; U937 Cells | 2005 |
Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin | 2003 |
Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase.
Topics: Androstadienes; Apoptosis; Calcium Pyrophosphate; Caspase 3; Caspases; Cell Degranulation; Crystallization; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Muramidase; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Superoxides; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Opposite effects of inhibitors of mitogen-activated protein kinase pathways on the egr-1 and beta-globin expression in erythropoietin-responsive murine erythroleukemia cells.
Topics: Animals; Butadienes; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Erythropoietin; Flavonoids; Gene Expression Regulation, Neoplastic; Globins; Imidazoles; Immediate-Early Proteins; Leukemia, Erythroblastic, Acute; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-fos; Pyridines; Transcription Factors; Tumor Cells, Cultured | 2004 |
Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin.
Topics: Adenocarcinoma, Papillary; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antioxidants; Apoptosis; Cell Division; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Flavonoids; G1 Phase; Gene Expression; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Estrogen; Tamoxifen | 2004 |
Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells.
Topics: Apoptosis; Cadmium; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Flavonoids; G1 Phase; Gene Expression Regulation, Neoplastic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Humans; Imidazoles; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; Proteins; Pyridines; Resting Phase, Cell Cycle; Stomach Neoplasms; Up-Regulation | 2004 |
Shear stress-induced up-regulation of the intermediate-conductance Ca(2+)-activated K(+) channel in human endothelium.
Topics: Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Pyridines; Regional Blood Flow; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stress, Mechanical; Umbilical Veins | 2003 |
Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bronchi; Cells, Cultured; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Interferon-gamma; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Organophosphonates; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Pyridines; Pyrones | 2004 |
The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells.
Topics: Binding Sites; Breast Neoplasms; Cell Line, Tumor; Collagen Type I; Down-Regulation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; In Vitro Techniques; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2003 |
Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells.
Topics: Air Pollutants; Amphiregulin; Bronchi; Cells, Cultured; EGF Family of Proteins; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Gene Expression Regulation; Glycoproteins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Particle Size; Pyridines; Reactive Oxygen Species; Signal Transduction; Vehicle Emissions | 2004 |
Bacterial GroEL-like heat shock protein 60 protects epithelial cells from stress-induced death through activation of ERK and inhibition of caspase 3.
Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Chaperonin 60; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Keratinocytes; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Ultraviolet Rays | 2004 |
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.
Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins | 2003 |
Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Annexin A5; Apoptosis; Blotting, Western; Carrier Proteins; Caspases; Cell Line, Tumor; Cell Survival; Chromones; Cycloheximide; DNA Fragmentation; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; Lung Neoplasms; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction | 2004 |
Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.
Topics: Antibodies, Monoclonal; Carrier Proteins; CD40 Antigens; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Ligands; MAP Kinase Signaling System; Membrane Proteins; Monocytes; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyridines; Recombinant Proteins; Repressor Proteins; Sulfonamides | 2004 |
Evidence that nitroprusside stimulates glucose uptake in isolated rat cardiomyocytes via mitogen-activated protein kinase.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ferricyanides; Flavonoids; Glucose; Imidazoles; Male; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Spermine | 2003 |
Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression.
Topics: Animals; Cell Line; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Flavonoids; Gene Expression; Imidazoles; Interleukins; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells.
Topics: Amidines; Catechin; Chromans; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Kinase 4; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines | 2004 |
T cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 expression via Ras activation.
Topics: Animals; Apoptosis; Binding Sites; Binding, Competitive; Blotting, Northern; Cell Nucleus; Dexamethasone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, Reporter; Glucocorticoids; Imidazoles; Immunoblotting; Kinetics; Luciferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Pyridines; ras Proteins; Receptors, Antigen, T-Cell; Repressor Proteins; Signal Transduction; Thymus Gland; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
Native LDL induces interleukin-8 expression via H2O2, p38 Kinase, and activator protein-1 in human aortic smooth muscle cells.
Topics: Aorta; Caffeic Acids; Cells, Cultured; Coronary Vessels; Dactinomycin; Dose-Response Relationship, Drug; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Interleukin-8; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; Pyridines; Sesquiterpenes; Time Factors; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2004 |
Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells.
Topics: Benzoquinones; Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dental Pulp; Dexamethasone; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Signal Transduction; Sulfonamides | 2004 |
Regulation of the circadian oscillator in Xenopus retinal photoreceptors by protein kinases sensitive to the stress-activated protein kinase inhibitor, SB 203580.
Topics: Animals; Casein Kinases; Circadian Rhythm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Light; Male; MAP Kinase Kinase 4; Melatonin; Mitogen-Activated Protein Kinase Kinases; Oscillometry; Phosphorylation; Photoreceptor Cells; Precipitin Tests; Protein Isoforms; Protein Kinases; Pyridines; Time Factors; Transcription Factors; Xenopus | 2004 |
Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition.
Topics: 3' Untranslated Regions; Animals; Anisomycin; Anthracenes; Butadienes; Cell Line; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heterogeneous-Nuclear Ribonucleoproteins; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Nitriles; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, beta; RNA Stability; Signal Transduction | 2004 |
Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells.
Topics: Blotting, Western; Caco-2 Cells; Cycloheximide; Dactinomycin; Electrophoretic Mobility Shift Assay; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Proteins; Imidazoles; Interleukin-1; Interleukin-6; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1.
Topics: Apoptosis; CD11 Antigens; CD11b Antigen; Cell Cycle; Cell Division; Cell Survival; Chromones; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavonoids; Humans; Hydantoins; Imidazoles; Macrophages; Morpholines; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Prostaglandin D2; Pyridines; Time Factors; Tumor Cells, Cultured | 2004 |
Vasoactive intestinal peptide induces IL-8 production in human colonic epithelial cells via MAP kinase-dependent and PKA-independent pathways.
Topics: Cell Polarity; Colon; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flavonoids; HT29 Cells; Humans; Imidazoles; Interleukin-8; Intestinal Mucosa; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Vasoactive Intestinal Peptide | 2004 |
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway.
Topics: Alzheimer Disease; Animals; Cell Culture Techniques; Cell Survival; DNA Primers; Enzyme Inhibitors; Flavonoids; Hippocampus; Humans; Imidazoles; Interleukin-6; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; tau Proteins | 2004 |
p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats.
Topics: Animals; Aorta; Calmodulin-Binding Proteins; Desoxycorticosterone; Endothelin-1; Flavonoids; Hypertension; Imidazoles; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Sodium Chloride, Dietary; Vasoconstriction | 2004 |
Identification of proteins differentially expressed during chondrogenesis of mesenchymal cells.
Topics: Animals; Carbazoles; Cell Differentiation; Cells, Cultured; Chick Embryo; Chondrocytes; Chondrogenesis; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Mesoderm; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Proteins; Proteome; Pyridines; Signal Transduction; Time Factors | 2004 |
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Cell Cycle; Chromans; Enzyme Inhibitors; Female; Flavonoids; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteins; Pyridines; RNA, Small Interfering; Signal Transduction; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2004 |
Effect of transforming growth factor-beta on activity of connective tissue growth factor gene promoter in mouse NIH/3T3 fibroblasts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Flavonoids; Imidazoles; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Luciferases; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
HERG K channel conductance promotes H2O2-induced apoptosis in HEK293 cells: cellular mechanisms.
Topics: Anti-Arrhythmia Agents; Caspase 3; Caspase 9; Caspases; Cell Line; DNA Fragmentation; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; p38 Mitogen-Activated Protein Kinases; Piperidines; Poly(ADP-ribose) Polymerases; Potassium Channels, Voltage-Gated; Pyridines; Signal Transduction | 2004 |
Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions.
Topics: Animals; Blotting, Northern; Curcumin; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Flavonoids; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Phosphorylation; Pulmonary Artery; Pyridines; RNA, Messenger; Sheep; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tetrahydroisoquinolines; Tumor Necrosis Factor-alpha | 2004 |
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunohistochemistry; Laminin; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Pyridines; Serine; Signal Transduction; Transfection; Urinary Bladder Neoplasms | 2004 |
[Effects of mitogen activated protein kinase signal transduction pathways on heat shock protein 70 gene expression in endothelial cells exposed to benzo(a)pryene].
Topics: Animals; Benzo(a)pyrene; Blotting, Western; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Flavonoids; HSP70 Heat-Shock Proteins; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Swine | 2004 |
Bismuth subsalicylate increases intracellular Ca2+, MAP-kinase activity, and cell proliferation in normal human gastric mucous epithelial cells.
Topics: Acetates; Bismuth; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gastric Mucosa; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Organometallic Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Calcium-Sensing; Salicylates; Signal Transduction | 2004 |
[Potential mechanism underlying down-regulation of albumin expression induced by lipopolysaccharide in rat hepatocytes].
Topics: Albumins; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Hepatocytes; Imidazoles; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2004 |
NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway.
Topics: Aldehydes; Animals; Biological Transport; DNA-Binding Proteins; Endothelial Cells; Enzyme Inhibitors; Flavonoids; I-kappa B Kinase; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; NF-kappaB-Inducing Kinase; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Prostate; Protein Serine-Threonine Kinases; Pyridines; Rats; Transcription Factor RelA; Transfection | 2004 |
Staphylococcus aureus peptidoglycan stimulates granulocyte macrophage colony-stimulating factor production from human epidermal keratinocytes via mitogen-activated protein kinases.
Topics: Cells, Cultured; Chemokine CCL5; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Flavonoids; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Humans; Imidazoles; Keratinocytes; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Peptidoglycan; Phosphorylation; Pyridines; Receptors, Cell Surface; RNA, Messenger; Staphylococcus aureus; Toll-Like Receptors | 2004 |
Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
Topics: Angiotensin II; Animals; Anthracenes; Blotting, Western; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Kidney; Losartan; Mice; Microscopy, Fluorescence; Onium Compounds; PAX2 Transcription Factor; Phosphorylation; Plasmids; Pyridines; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors; Tyrphostins; Up-Regulation | 2004 |
Bacterial heat shock protein 60 may increase epithelial cell migration through activation of MAP kinases and inhibition of alpha6beta4 integrin expression.
Topics: Animals; Bacterial Proteins; Cell Adhesion; Cell Line; Cell Movement; Chaperonin 60; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Humans; Imidazoles; Integrin alpha6beta4; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Protein Subunits; Pyridines | 2004 |
Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580.
Topics: Cells, Cultured; Cyclosporine; Cytokines; Dexamethasone; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Humans; Imidazoles; Interleukin-4; Interleukin-6; Mast Cells; Phosphorylation; Pyridines; RNA, Messenger; Serotonin; Tumor Necrosis Factor-alpha | 2004 |
Interleukin-8 production by THP-1 cells stimulated by Salmonella enterica serovar Typhimurium porins is mediated by AP-1, NF-kappaB and MAPK pathways.
Topics: Cell Line; Flavonoids; Humans; Imidazoles; Interleukin-8; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Porins; Protein Binding; Pyridines; Salmonella typhimurium; Signal Transduction; Transcription Factor AP-1; Tyrphostins; Up-Regulation | 2004 |
Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.
Topics: Animals; Blotting, Western; Cadmium; Dinoprostone; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kinetics; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; Phospholipases A; Phospholipases A2; Phosphorylation; Pregnancy; Protein Kinase C; Pyridines; Signal Transduction | 2004 |
Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Topics: Androstadienes; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Tenascin; Wortmannin | 2004 |
p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats.
Topics: Animals; Endothelin-1; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstriction | 2004 |
Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter.
Topics: Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Osmolar Concentration; Pyridines; RNA, Messenger; Sulfonamides | 2004 |
RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Blotting, Western; Bone Marrow Cells; Carrier Proteins; Cathepsin K; Cathepsins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p19; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; Femur; Flavonoids; Gene Expression; Imidazoles; Isoenzymes; Macrophage Colony-Stimulating Factor; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Osteoclasts; Osteopetrosis; Pyridines; Radiography; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Tartrate-Resistant Acid Phosphatase; Tumor Suppressor Proteins | 2004 |
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2004 |
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.
Topics: Amphetamine; Animals; Anthracenes; Antimanic Agents; Blotting, Western; Carbamazepine; Cell Line; Cell Survival; Chloramphenicol O-Acetyltransferase; Corticosterone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Inositol; Lithium; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Receptors, Glucocorticoid; Tamoxifen; Tetradecanoylphorbol Acetate; Valproic Acid | 2004 |
Different roles of ERK and p38 MAP kinases during tube formation from endothelial cells cultured in 3-dimensional collagen matrices.
Topics: Apoptosis; Blotting, Western; Caspase Inhibitors; Caspases; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Gels; Gene Expression Regulation; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Umbilical Veins | 2004 |
Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.
Topics: Animals; Calcium; Cell Line; Cholera Toxin; Dopamine Antagonists; Down-Regulation; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Kidney Tubules, Proximal; Pertussis Toxin; Protein Kinase C; Pyridines; Rats; Rats, Inbred SHR; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, G-Protein-Coupled; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulpiride; Tetrahydronaphthalenes; Type C Phospholipases | 2004 |
MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury.
Topics: Animals; Anthracenes; Burns; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Immunophenotyping; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha | 2004 |
Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesis.
Topics: Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Immunoassay; Immunoblotting; Immunohistochemistry; Indomethacin; Lipoproteins, LDL; Membrane Proteins; NF-kappa B; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane A2; Time Factors; Umbilical Veins | 2004 |
Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways.
Topics: Animals; Anthracenes; Bradykinin; Dactinomycin; Dexamethasone; Electromyography; Enzyme Inhibitors; Flavonoids; Imidazoles; In Vitro Techniques; Interleukin-4; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Pyridines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Trachea | 2004 |
Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells.
Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; HT29 Cells; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Serum; Stomach Neoplasms | 2004 |
Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bronchoalveolar Lavage Fluid; Bucladesine; CREB-Binding Protein; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Rolipram; Superoxides; Trans-Activators | 2004 |
Role of defective ERK phosphorylation in the impaired GM-CSF-induced oxidative response of neutrophils in elderly humans.
Topics: Aged; Aging; Blotting, Western; Cell Separation; Enzyme Inhibitors; Female; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; In Vitro Techniques; Indicators and Reagents; Male; Mitogen-Activated Protein Kinases; Neutrophils; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 2004 |
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate | 2004 |
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
Topics: Androstadienes; Animals; Anthracenes; Cell Line; Cell Movement; Cell Survival; Chemokine CCL4; Chemotaxis; Chromones; Complement C5a; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophage Inflammatory Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin | 2004 |
Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells.
Topics: Anthracenes; Antigens, CD; Biological Transport; Cell Differentiation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dendritic Cells; Dextrans; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorescein-5-isothiocyanate; HLA-DR Antigens; Humans; Imidazoles; Interleukin-12; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Subunits; Pyridines; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins | 2004 |
CD38 cleavage in fMLP- and IL-8-induced chemotaxis is dependent on p38 MAP kinase but independent of p44/42 MAP kinase.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Chemotaxis; Cyclic ADP-Ribose; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-8; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphorylation; Pyridines; Receptors, Formyl Peptide; Receptors, Lipoxin; Tosyl Compounds | 2005 |
Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin45 in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Connexin 43; Connexins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gap Junction alpha-5 Protein; Gap Junctions; Imidazoles; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2004 |
p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression.
Topics: Butyrates; Caco-2 Cells; Cell Differentiation; Flavonoids; Gene Expression; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Calcitriol | 2004 |
Retinol binding protein isolated from acute renal failure patients inhibits polymorphonuclear leucocyte functions.
Topics: Acute Kidney Injury; Apoptosis; Chemotaxis, Leukocyte; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Neutrophils; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pyridines; Retinol-Binding Proteins; Tetradecanoylphorbol Acetate | 2004 |
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
Topics: Anthracenes; Aorta; Arteriosclerosis; Cell Adhesion; Depression, Chemical; Endothelial Cells; Endothelium, Vascular; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; NADPH Oxidases; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Recombinant Fusion Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Transcription Factor AP-1; Transcription, Genetic; Transduction, Genetic; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspases; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunotoxins; Jurkat Cells; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Mycotoxins; Phosphorylation; Pyridines; T-Lymphocytes; Trichothecenes | 2005 |
Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha.
Topics: Anthracenes; Antigens, CD; Antigens, Surface; B7-2 Antigen; Blotting, Western; Cadherins; CD83 Antigen; Enzyme Inhibitors; Female; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunoglobulins; Irritants; Langerhans Cells; Lectins, C-Type; Mannose-Binding Lectins; MAP Kinase Signaling System; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Nickel; Pyridines; Receptors, CCR7; Receptors, Chemokine; Tumor Necrosis Factor-alpha | 2005 |
Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.
Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Line; Chickens; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Deletion; Gene Silencing; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Imidazoles; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Mice; NIH 3T3 Cells; Nuclear Proteins; Plasmids; Protein Structure, Tertiary; Proteins; Pyridines; ras Proteins; Retroviridae; Signal Transduction; Thymidine; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2005 |
N-methyl-D-aspartate and brain-derived neurotrophic factor induce distinct profiles of extracellular signal-regulated kinase, mitogen- and stress-activated kinase, and ribosomal s6 kinase phosphorylation in cortical neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; N-Methylaspartate; Phosphorylation; Pyridines; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa | 2005 |
[The role of MAPK signal transduction pathway in killing tumor cells by Mtb-Ag activated gammadelta T cells].
Topics: Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Line, Tumor; Cell Proliferation; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Lectins, C-Type; Leukocytes, Mononuclear; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mycobacterium tuberculosis; Neoplasms; Protein Kinase Inhibitors; Pyridines; T-Lymphocytes | 2005 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Chemokines; Chromones; Cytokines; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-17; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Morpholines; NF-kappa B; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Wortmannin | 2005 |
SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells.
Topics: Adenoviridae; Animals; beta-Galactosidase; Blotting, Western; Cells, Cultured; Collagen; Collagen Type I; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Imidazoles; Liver; Male; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Ribonucleases; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Smad Proteins; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta | 2005 |
Regulation of corticotropin-releasing factor receptor type 2beta mRNA by mitogen-activated protein kinases in aortic smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anisomycin; Aorta; Cell Line; Corticotropin-Releasing Hormone; Down-Regulation; Flavonoids; Gene Expression Regulation; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Receptors, Corticotropin-Releasing Hormone; Ribonucleases; Up-Regulation; Urocortins | 2005 |
Interleukin-1beta-induced transdifferentiation of renal proximal tubular cells is mediated by activation of JNK and p38 MAPK.
Topics: Actins; Anthracenes; Cell Differentiation; Cell Line; Cell Movement; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Keratins; Kidney Tubules, Proximal; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction | 2005 |
Salicylic acid alters endothelin-1 binding in intact adult rat ventricular myocytes.
Topics: Animals; Cell Membrane; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heart Ventricles; Imidazoles; Intracellular Signaling Peptides and Proteins; Male; Myocytes, Cardiac; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Salicylic Acid; Temperature | 2004 |
Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation.
Topics: Anthracenes; Apoptosis; Bupleurum; Chromatography, Liquid; Drugs, Chinese Herbal; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Keratin-8; Keratins; Mass Spectrometry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pyridines; Tumor Cells, Cultured | 2005 |
[ERK1/2 and p38 kinases are important regulators in P2Y receptor-mediated prostate cancer invasion].
Topics: Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Pyridines; Receptors, Purinergic P2; Signal Transduction | 2005 |
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.
Topics: Adipocytes; Animals; Biological Transport; Cell Line; Cells, Cultured; Fibroblasts; Flavonoids; Gene Expression Regulation; Glucose; Humans; Imidazoles; MAP Kinase Kinase Kinases; Muscle Fibers, Skeletal; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; PPAR delta; Pyridines; Thiazoles | 2005 |
Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells.
Topics: Animals; Blotting, Western; Cell Communication; Cell Differentiation; Connexin 43; Connexins; Flavonoids; Gap Junction beta-1 Protein; Gap Junctions; Imidazoles; Neurons; Pyridines; Rats; Stem Cells; Tetradecanoylphorbol Acetate | 2005 |
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.
Topics: Animals; Butadienes; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Immunoblotting; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2005 |
Stretch-induced cell proliferation is mediated by FAK-MAPK pathway.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Fibroblasts; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Rats; Signal Transduction; Stress, Mechanical; Tyrosine | 2005 |
Inhibition of monocyte-derived dendritic cell differentiation and interleukin-12 production by complement iC3b via a mitogen-activated protein kinase signalling pathway.
Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Complement C3b; Cross-Linking Reagents; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Immunoglobulin M; Interleukin-10; Interleukin-12; Interleukin-4; Ligands; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Monocytes; Phosphorylation; Pyridines; Sheep; Time Factors; Ultraviolet Rays | 2005 |
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Induction; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Tyrphostins | 2004 |
p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development.
Topics: Actins; alpha Catenin; Animals; Blastocyst; Cadherins; Cell Adhesion Molecules; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Embryonic Development; Enzyme Inhibitors; Female; Flavonoids; Fluorescent Antibody Technique, Indirect; Heat-Shock Proteins; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 3; Morula; p38 Mitogen-Activated Protein Kinases; Pregnancy; Protein Serine-Threonine Kinases; Pyridines; Pyrimidines; Signal Transduction; Time Factors | 2005 |
Differential Involvement of ERK2 and p38 in platelet adhesion to collagen.
Topics: Actins; Collagen; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Image Processing, Computer-Assisted; Imidazoles; Immunoblotting; Integrin alpha2beta1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Protein Binding; Pyridines; Stress, Mechanical; Time Factors; von Willebrand Factor | 2005 |
MAPKs mediate the activation of cytosolic phospholipase A2 by amyloid beta(25-35) peptide in bovine retina pericytes.
Topics: Amyloid beta-Peptides; Animals; Arachidonic Acid; Biological Transport; Cattle; Cell Nucleus; Cytosol; Enzyme Activation; Flavonoids; Imidazoles; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Pericytes; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Retina; RNA, Messenger | 2005 |
Sulindac sulfide-induced apoptosis in sinonasal cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma, Squamous Cell; Caspase Inhibitors; Flavonoids; Fluorescence; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Paranasal Sinus Neoplasms; Pyridines; Signal Transduction; Sulindac | 2005 |
ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta.
Topics: Adult; Blotting, Western; Cell Differentiation; Cell Separation; Chorionic Gonadotropin; Culture Media, Serum-Free; Densitometry; Enzyme Inhibitors; Female; Flavonoids; Fluorescent Antibody Technique; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Imidazoles; L-Lactate Dehydrogenase; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Placenta; Placental Lactogen; Pregnancy; Pyridines; Signal Transduction; Trophoblasts | 2005 |
delta-Opioid agonist induced regulation of E2F1 DNA binding activity in NG108-15 cells.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Electrophoretic Mobility Shift Assay; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Imidazoles; Mice; Neuroblastoma; Protein Binding; Pyridines; Receptors, Opioid, delta; Thymidine; Transcription Factors; Tritium | 2005 |
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Heart Ventricles; Imidazoles; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Serine; Time Factors | 2005 |
Characterization of cAMP-dependent proteolysis of GATA-6.
Topics: Animals; Base Sequence; Benzylamines; Binding Sites; Bucladesine; Carbazoles; Cell Nucleus; CHO Cells; Cricetinae; Cyclic AMP; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; GATA6 Transcription Factor; Humans; Imidazoles; Indole Alkaloids; Isoquinolines; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Molecular Sequence Data; Mutation; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Prostaglandin D2; Proteasome Endopeptidase Complex; Protein Binding; Pyridines; src-Family Kinases; Sulfonamides; Transcription Factors | 2005 |
Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Blotting, Northern; Catalase; Cell Hypoxia; Cell Line; Flavonoids; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Immunoblotting; Microscopy, Fluorescence; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyridines; Pyrimidines; Rabbits; RNA, Messenger; Rotenone; Wortmannin | 2005 |
Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.
Topics: Androstadienes; Anthocyanins; Anthracenes; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Cell Survival; Cytochromes c; DNA, Mitochondrial; Dose-Response Relationship, Drug; Fas Ligand Protein; Flavonoids; Flowers; Hibiscus; HL-60 Cells; Humans; Imidazoles; Membrane Glycoproteins; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Proto-Oncogene Proteins c-jun; Pyridines; RNA, Messenger; Time Factors; Wortmannin | 2005 |
Polypeptide from Chlamys farreri inhibits murine thymocytes apoptosis and modulates UVB induced signaling pathway activation.
Topics: Analysis of Variance; Animals; Anthracenes; Apoptosis; Blotting, Western; Cells, Cultured; DNA Fragmentation; Flavonoids; Imidazoles; Mice; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinases; Mollusca; Peptides; Pyridines; Signal Transduction; Thymus Gland; Ultraviolet Rays | 2005 |
Elevated expression of NF-kappaB and Bcl-2 proteins in C2C12 myocytes during myogenesis is affected by PD98059, LY294002 and SB203580.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Chromones; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; Morpholines; Muscle Development; Myoblasts; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines | 2005 |
Cell-specific posttranscriptional regulation of CFTR gene expression via influence of MAPK cascades on 3'UTR part of transcripts.
Topics: 3' Untranslated Regions; Base Sequence; Cell Line; Cystic Fibrosis Transmembrane Conductance Regulator; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinase Kinases; Pyridines; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2005 |
Involvement of extracellular regulated kinase and p38 kinase in hippocampal seizure tolerance.
Topics: Animals; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; Imidazoles; Male; MAP Kinase Signaling System; Nerve Degeneration; Neurons; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred F344; Status Epilepticus | 2005 |
Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells.
Topics: Cells, Cultured; Cytomegalovirus; Enzyme Inhibitors; Eukaryotic Initiation Factor-4F; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gene Expression Regulation, Viral; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Virus Replication | 2005 |
Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF).
Topics: Carrier Proteins; Cell Line, Tumor; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunohistochemistry; In Situ Hybridization; Membrane Proteins; Morpholines; Neoplasm Proteins; Neoplasms; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Transcription, Genetic; Up-Regulation; Vascular Endothelial Growth Factor A | 2005 |
A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cerebellar Neoplasms; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Medulloblastoma; MEF2 Transcription Factors; Mice; Mitogen-Activated Protein Kinase 7; Myogenic Regulatory Factors; Neurotrophin 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, trkC; Transcription Factors; Transfection | 2005 |
Activation of mitogen activated protein kinase pathways and melanogenesis by novel nitro-derivatives of 7-hydroxycomarin in human malignant melanoma cells.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Colforsin; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Melanins; Melanoma; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Nitro Compounds; Pyridines; Umbelliferones | 2005 |
[Transforming growth factor-beta1 induced phenotypic differentiation of human lung fibroblasts through mitogen activated protein kinase-dependent pathway].
Topics: Actins; Cell Line; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Pyridines; RNA, Messenger; Transforming Growth Factor beta1 | 2005 |
Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.
Topics: Apoptosis; Blotting, Western; Chromones; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Interleukin-10; Lipopolysaccharides; Morpholines; Neutrophils; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Pyridines | 2005 |
Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Enzyme Activation; Flavonoids; Glutathione; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Tumor Suppressor Protein p53 | 2005 |
Ligand concentration is a driver of divergent signaling and pleiotropic cellular responses to FGF.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Fibroblast Growth Factor 2; Flavonoids; Imidazoles; Ligands; Mice; Models, Biological; Neurons; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction | 2006 |
Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Nerve Growth Factor; Neurons; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins B-raf; Pyridines; ras Proteins; Rats | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
JTT-705 blocks cell proliferation and angiogenesis through p38 kinase/p27(kip1) and Ras/p21(waf1) pathways.
Topics: Amides; Atherosclerosis; Cell Division; Cells, Cultured; Coronary Vessels; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Endothelium, Vascular; Enzyme Inhibitors; Esters; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Neovascularization, Pathologic; p38 Mitogen-Activated Protein Kinases; Pyridines; ras Proteins; Sulfhydryl Compounds; Up-Regulation; Vascular Endothelial Growth Factor A | 2005 |
Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Astrocytes; Brain Ischemia; Cell Culture Techniques; Cell Death; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Imidazoles; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Molsidomine; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.
Topics: Aldehydes; Animals; Cell Nucleus; Cells, Cultured; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Epithelial Cells; Flavonoids; gamma-Glutamyltransferase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; Nuclear Respiratory Factor 1; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Rats; Response Elements; Signal Transduction; Transcription Factors | 2006 |
Low concentrations of nitric oxide (NO) induced cell death in PC12 cells through activation of p38 mitogen-activated protein kinase (p38 MAPK) but not via extracellular signal-regulated kinases (ERK1/2) or c-Jun N-terminal protein kinase (JNK).
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pyridines; Rats; Time Factors | 2006 |
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Imidazoles; Immune Sera; Inflammation; Interleukin-6; Male; Mitogen-Activated Protein Kinase 1; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rabbits; Signal Transduction; Turpentine | 2006 |
Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes.
Topics: Animals; Calcium Phosphates; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Crystallization; Enzyme Induction; Flavonoids; Imidazoles; Interleukin-1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Pyridines; RNA, Messenger; Transcription, Genetic | 2005 |
Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase.
Topics: Anthracenes; Antibiotics, Antineoplastic; Antioxidants; Blotting, Western; Carbazoles; Carvedilol; Catecholamines; Cell Line; Doxorubicin; Enzyme Activation; Flavonoids; Humans; Imidazoles; Imidazolines; Janus Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Propanolamines; Protein-Tyrosine Kinases; Pyridines; Razoxane | 2006 |
Enteropathogenic Escherichia coli outer membrane proteins induce iNOS by activation of NF-kappaB and MAP kinases.
Topics: Bacterial Outer Membrane Proteins; Caco-2 Cells; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Escherichia coli; Flavonoids; Humans; Imidazoles; Luminescent Measurements; Mitogen-Activated Protein Kinases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Nitrites; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfones | 2004 |
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes.
Topics: Anthracenes; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Signal Transduction | 2005 |
Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line.
Topics: Acrylates; Animals; Cadherins; Cell Line; Cell Proliferation; Chromones; Cytoskeletal Proteins; Down-Regulation; Flavonoids; Gene Expression Regulation, Enzymologic; Hepatocytes; Imidazoles; MAP Kinase Signaling System; Mice; Microvilli; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-raf; Pyridines; Signal Transduction; Snail Family Transcription Factors; Time Factors; Transcription Factors; Up-Regulation | 2006 |
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Imidazoles; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interleukin-1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Serine; Synaptotagmin I | 2005 |
Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line.
Topics: Aniline Compounds; Anisomycin; Anthracenes; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-4E; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Purines; Pyridines; RNA, Messenger; Shiga Toxin 1; Time Factors | 2006 |
Effect of biologic mediators on ciprofloxacin accumulation by gingival fibroblasts.
Topics: Adult; Anti-Infective Agents; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ciprofloxacin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Fluorescence; Gingiva; Humans; Imidazoles; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes.
Topics: Cell Size; Cells, Cultured; Extracellular Matrix Proteins; Flavonoids; Heart Ventricles; Humans; Imidazoles; Infant; Janus Kinase 1; Leptin; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Tyrphostins | 2006 |
The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis.
Topics: Algorithms; Anthracenes; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Flavonoids; Genes, bcl-2; Genes, p53; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Silymarin; Ultraviolet Rays | 2006 |
Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.
Topics: Animals; Aspartic Acid Endopeptidases; Cell Line; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelin-Converting Enzymes; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Kinase 1; Metalloendopeptidases; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Receptor, Endothelin A; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transfection | 2006 |
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.
Topics: Adamantane; Anisomycin; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cinnamates; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; MAP Kinase Kinase Kinase 1; Mutagenesis, Site-Directed; Nuclear Receptor Subfamily 4, Group A, Member 1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transcription Factors | 2006 |
Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways.
Topics: Adiponectin; Animals; Butadienes; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Enzyme Activation; Flavonoids; Imidazoles; Isoquinolines; Leptin; Macrophages, Peritoneal; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tumor Necrosis Factor-alpha | 2005 |
Modulatory effect of interleukin-1beta on rat isolated basilar artery contraction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; Animals; Basilar Artery; Calcium-Calmodulin-Dependent Protein Kinases; Cyclohexenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; In Vitro Techniques; Interleukin-1; Male; Monoterpenes; Phenylephrine; Prazosin; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Vasoconstriction; Vasoconstrictor Agents | 2006 |
Inhibition of mitogen-activated protein kinase kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Butadienes; Cell Survival; DNA; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; Humans; Imidazoles; MAP Kinase Kinase 1; Nitriles; Oxides; p38 Mitogen-Activated Protein Kinases; Pyridines; Thymidine; Tissue Culture Techniques; Tumor Cells, Cultured | 2005 |
Heme oxygenase 1 mediates anti-inflammatory effects of 2',4',6'-tris(methoxymethoxy) chalcone.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Blotting, Northern; Blotting, Western; Cell Line; Chalcones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression; Glutathione; Heme Oxygenase-1; Imidazoles; Intracellular Fluid; Lipopolysaccharides; Macrophage Activation; Macrophages; Mitogen-Activated Protein Kinases; Molecular Structure; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pyridines; Reactive Oxygen Species; RNA, Messenger | 2006 |
ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Imidazoles; Mice; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Pyridines; ras Proteins; RNA, Small Interfering; Thymosin; Transfection | 2006 |
Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines.
Topics: Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Kinetics; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Stomach Neoplasms; Urokinase-Type Plasminogen Activator | 2006 |
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Animals, Newborn; Cell Line; Cell Proliferation; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Enzyme Activation; Flavonoids; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Human Growth Hormone; Imidazoles; Insulin-Secreting Cells; Isoquinolines; Liraglutide; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Signal Transduction; Stimulation, Chemical; Sulfonamides; Transcription, Genetic; Transduction, Genetic; Wortmannin | 2006 |
p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes.
Topics: Adult; Aggrecans; Cell Line, Tumor; Cells, Cultured; Chondrocytes; Chondroitin Sulfate Proteoglycans; Down-Regulation; Extracellular Matrix Proteins; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; Lectins, C-Type; Leukocytes, Mononuclear; Male; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Interleukin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.
Topics: Adiponectin; Cell Proliferation; Chemokine CCL2; Cytokines; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; HT29 Cells; Humans; Imidazoles; Indoles; Interleukin-1; Interleukin-8; Intestinal Mucosa; Isoquinolines; Maleimides; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sulfonamides; Sulfones | 2006 |
Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation.
Topics: Adolescent; Adult; Anthracenes; Blood Proteins; Culture Media, Conditioned; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keloid; Keratinocytes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta2; Transforming Growth Factor beta3 | 2006 |
Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-10; Monocytes; Morpholines; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Receptors, Formyl Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Amyloid A Protein; Sulfones; Tumor Necrosis Factor-alpha | 2006 |
[p38/ERK signal pathways regulating the expression of type I collagen and activity of MMP-2 in TGF-beta1-stimulated HLF-02 cells].
Topics: Blotting, Western; Cell Line; Collagen Type I; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta1 | 2006 |
Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells.
Topics: Antioxidants; Ascorbic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Extracts; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme Inhibitors; Epithelial Cells; Esophagus; Flavonoids; Helicobacter pylori; Humans; Imidazoles; Interleukin-8; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Pyridines; Signal Transduction; Transcription Factor AP-1 | 2006 |
[Regulation of heat shock protein 27/activating transcription factor-5 complex and its implication in podocyte apoptosis induced by high glucose].
Topics: Activating Transcription Factors; Animals; Apoptosis; Blotting, Western; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Glucose; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Imidazoles; MAP Kinase Signaling System; Mice; Microscopy, Fluorescence; Molecular Chaperones; Multiprotein Complexes; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Podocytes; Pyridines | 2006 |
p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.
Topics: Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Differentiation; Cell Proliferation; Cytochromes c; Deferoxamine; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Ferric Compounds; Flavonoids; Humans; Imidazoles; Iron Chelating Agents; Keratinocytes; Mouth Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Precursors; Pyridines | 2006 |
Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts.
Topics: Adolescent; Adult; Butadienes; Chromones; Fibroblasts; Flavonoids; Humans; Imidazoles; Interleukin-8; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Proteinase-Activated; Signal Transduction; Skin; STAT3 Transcription Factor; Thrombin; Tyrphostins | 2006 |
Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Heptanoic Acids; Imidazoles; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrroles; Vascular Endothelial Growth Factor A | 2006 |
Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension.
Topics: Animals; Cell Cycle Proteins; Cells, Cultured; Cyclin D2; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclins; E2F4 Transcription Factor; Flavonoids; Gene Expression; Gene Expression Profiling; Heparin; Hypertension, Pulmonary; Hypoxia; Imidazoles; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Retinoblastoma-Like Protein p107 | 2006 |
Involvement of p38 MAP kinase and Smad3 in TGF-beta-mediated mast cell functions.
Topics: Animals; Anthracenes; Blotting, Western; Bone Marrow Cells; Cell Movement; Cell Proliferation; Cells, Cultured; Chymases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad3 Protein; Transforming Growth Factor beta; Tryptases; Up-Regulation | 2006 |
Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle.
Topics: Antigens, Bacterial; Bacterial Proteins; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Cyclin D1; Flavonoids; Flow Cytometry; Gene Expression; Helicobacter Infections; Helicobacter pylori; Humans; Imidazoles; Luciferases; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; Phosphorylation; Protein Binding; Pyridines; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transcription Factor AP-1; Transcription Factors | 2006 |
Endothelin-1 activates Homer 1alpha expression via mitogen-activated protein kinase in cardiac myocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Blotting, Northern; Carrier Proteins; Cells, Cultured; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Homer Scaffolding Proteins; Imidazoles; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Protein Isoforms; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors | 2006 |
Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Anthracenes; Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line; Enzyme Induction; Flavonoids; Humans; Imidazoles; Interferon-gamma; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate | 2006 |
Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2
Topics: Blotting, Western; Bronchi; Cell Line, Transformed; Cell Survival; Chemokine CCL2; Dose-Response Relationship, Drug; Enzyme Activation; Epithelial Cells; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-13; Interleukin-4; Interleukins; Janus Kinase 2; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Tyrphostins; Up-Regulation | 2006 |
[Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Epidermal Cells; Epidermal Growth Factor; Epidermis; Female; Flavonoids; Flow Cytometry; Hyaluronan Receptors; Imidazoles; Immunohistochemistry; Integrin beta1; Keratin-19; Keratins; Male; Mechanotransduction, Cellular; Mesenchymal Stem Cells; Pyridines; Rats; Rats, Wistar; Time Factors | 2006 |
Cytokine-induced nitric-oxide-dependent apoptosis in mouse osteoblastic cells: involvement of p38MAP kinase.
Topics: Animals; Apoptosis; Cell Line; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Interferon-gamma; Interleukin-1beta; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
Ligustilide inhibits vascular smooth muscle cells proliferation.
Topics: 4-Butyrolactone; Animals; Anthracenes; Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Retinoblastoma Protein | 2006 |
ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Hydrogen Peroxide; I-kappa B Proteins; Imidazoles; Immunoblotting; Isoquinolines; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Myoblasts, Skeletal; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Serine; src-Family Kinases; Sulfonamides | 2006 |
Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor; Glioma; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; p38 Mitogen-Activated Protein Kinases; Pyridines | 2006 |
Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Endopeptidases; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, bcl-2; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Mice; Morpholines; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protozoan Proteins; Pyridines; Signal Transduction; Trypanosoma cruzi | 2006 |
Samul extract protects against the H2O2-induced apoptosis of H9c2 cardiomyoblasts via activation of extracellular regulated kinases (Erk) 1/2.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Line; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridines; Time Factors | 2006 |
The regulatory mechanism by which interleukin-6 stimulates GH-gene expression in rat GH3 cells.
Topics: Animals; Cell Line, Tumor; Chromones; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Growth Hormone; Imidazoles; Indoles; Interleukin-6; Maleimides; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor Pit-1; Transfection | 2006 |
The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cell Nucleus; Cell Survival; Chromones; Cyclooxygenase 2; Dinoprostone; Endocannabinoids; Endothelial Cells; Enzyme Activation; Flavonoids; Fluorescent Antibody Technique; Glycerides; Imidazoles; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Theilovirus | 2006 |
Endoglin modulation of TGF-beta1-induced collagen synthesis is dependent on ERK1/2 MAPK activation.
Topics: Animals; Antigens, CD; Blotting, Northern; Blotting, Western; Cell Line; Collagen; Endoglin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Pyridines; Rats; Receptors, Cell Surface; RNA, Messenger; Time Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Ketamine-induced cardiac depression is associated with increase in [Mg2+]i and activation of p38 MAP kinase and ERK 1/2 in guinea pig.
Topics: Animals; Cytoplasm; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flavonoids; Guinea Pigs; Heart; Imidazoles; Ketamine; Magnesium; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines | 2006 |
Bone marrow derived mast cell acquire responsiveness to substance P with Ca(2+) signals and release of leukotriene B(4) via mitogen-activated protein kinase.
Topics: Animals; Bone Marrow Cells; Calcium; Calcium Signaling; Coculture Techniques; Enzyme Inhibitors; Fibroblasts; Flavonoids; Histamine Release; Imidazoles; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; Pyridines; Species Specificity; Substance P | 2006 |
Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).
Topics: Anthracenes; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Emodin; Fibroblasts; Flavonoids; Humans; Imidazoles; Infant, Newborn; JNK Mitogen-Activated Protein Kinases; Luciferases; Male; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Rheum; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2006 |
Elevated reactive oxygen species but not glutathione regulate mercury resistance to AML-2/DX100 cells.
Topics: Acetylcysteine; Blotting, Western; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Hydrogen Peroxide; Imidazoles; Mercuric Chloride; Multidrug Resistance-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Probenecid; Pyridines; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Thiocarbamates | 2006 |
ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells.
Topics: Cells, Cultured; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Kidney Tubules, Proximal; p38 Mitogen-Activated Protein Kinases; Polyribosomes; Protein Biosynthesis; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Smad3 Protein; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta1 | 2006 |
Regulation of ROMK (Kir 1.1) channel expression in kidney thick ascending limb by hypertonicity: role of TonEBP and MAPK pathways.
Topics: Active Transport, Cell Nucleus; Animals; Cell Line; Cell Nucleus; Flavonoids; Imidazoles; In Vitro Techniques; Kidney Medulla; Loop of Henle; Male; Mannitol; MAP Kinase Signaling System; Mice; Osmolar Concentration; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Transcription Factors; Transcription, Genetic; Urea | 2006 |
The regulation of ATF3 gene expression by mitogen-activated protein kinases.
Topics: Activating Transcription Factor 3; Animals; Anisomycin; Chlorocebus aethiops; COS Cells; Enzyme Activation; Enzyme Induction; Flavonoids; Gene Expression Regulation; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription Factors | 2007 |
p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Colonic Neoplasms; Flavonoids; HCT116 Cells; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Sulindac | 2006 |
P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells.
Topics: Anthracenes; Apoptosis; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells.
Topics: Anthracenes; Apoptosis; Blotting, Western; Butyrates; Caspase 8; Cell Line, Tumor; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Histone Deacetylase Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid, Acute; Mannose; p38 Mitogen-Activated Protein Kinases; Pyridines; Translocation, Genetic | 2006 |
A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells.
Topics: Base Sequence; Cell Line, Transformed; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Chromones; Cobalt; Endothelial Cells; Endothelium, Vascular; Flavonoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Imidazoles; Interleukin-8; Molecular Sequence Data; Morpholines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; RNA, Messenger | 2006 |
ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells: involvement of PI3K and Erk signaling.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Chromones; ErbB Receptors; Flavonoids; Genes, ras; Genes, Reporter; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neuregulin-1; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyridines; Rats; Reactive Oxygen Species; Receptor, ErbB-4; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Transfection | 2006 |
Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts.
Topics: Anthracenes; Bone and Bones; Calcium; Calcium Signaling; Cations, Divalent; Cyclooxygenase 2; Dinoprostone; Estrenes; Fibroblasts; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Receptors, Calcium-Sensing; RNA, Messenger; Type C Phospholipases | 2006 |
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.
Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Imidazoles; Luciferases; Mice; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Pyridines | 2007 |
IL-12-induced T-bet expression and IFNgamma release in lymphocytes from asthmatics--role of MAPkinases ERK-1/-2, p38(MAPK) and effect of dexamethasone.
Topics: Adult; Asthma; Cells, Cultured; Dexamethasone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Gene Expression Regulation; Glucocorticoids; Humans; Imidazoles; Interferon-gamma; Interleukin-12; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Box Domain Proteins; T-Lymphocytes | 2007 |
Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility.
Topics: Animals; Animals, Newborn; Blotting, Western; Echocardiography; Flavonoids; Gene Expression; Heart Failure; Imidazoles; Mitogen-Activated Protein Kinase 1; Models, Animal; Muscle Proteins; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred WKY; RNA Interference; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Troponin I; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; Ventricular Dysfunction, Left | 2007 |
Interleukin-1beta up-regulates inducible nitric oxide by way of phosphoinositide 3-kinase-dependent in a cochlear cell model.
Topics: Animals; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; Imidazoles; Interleukin-1beta; Mice; Morpholines; Nitric Oxide Synthase Type II; Organ of Corti; Phosphatidylinositol 3-Kinases; Pyridines; Signal Transduction; Transcriptional Activation; Up-Regulation | 2006 |
Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Desoxycorticosterone; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Organ Size; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley | 2006 |
In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production.
Topics: Animals; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Ceruletide; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas, Exocrine; Pyridines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2006 |
Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases.
Topics: Cells, Cultured; Chaperonin 60; Cytokines; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Inflammation; Lipopolysaccharide Receptors; Monocytes; Mycobacterium tuberculosis; p38 Mitogen-Activated Protein Kinases; Pyridines | 2007 |
Serum amyloid A induces WISH cell apoptosis.
Topics: Amnion; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Cell Proliferation; Flavonoids; Gene Expression; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Pyridines; Radioligand Assay; Receptors, Formyl Peptide; Receptors, Lipoxin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Amyloid A Protein | 2007 |
p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion.
Topics: Androgens; Anthracenes; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-6; Male; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Pyridines; Ritodrine | 2007 |
Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells.
Topics: Actins; Capillary Permeability; Cell Line; Cytoskeleton; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycation End Products, Advanced; Humans; Imidazoles; MAP Kinase Signaling System; Microscopy, Fluorescence; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serum Albumin; Serum Albumin, Human | 2006 |
Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.
Topics: Amides; Anthracenes; Aorta; Blotting, Western; Boron Compounds; cdc42 GTP-Binding Protein; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Endothelial Cells; Enzyme Activation; Flavonoids; Humans; Imidazoles; Leucine; Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Protein Transport; Pyridines; rac1 GTP-Binding Protein; Thrombomodulin; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Adrenocorticotropin hormone stimulates interleukin-18 expression in human HaCaT keratinocytes.
Topics: Adrenocorticotropic Hormone; Caspase 1; Cell Line; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-18; Keratinocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Pituitary Hormone; RNA, Messenger | 2007 |
Soluble products from Eikenella corrodens induce cell proliferation and expression of interleukin-8 and adhesion molecules in endothelial cells via mitogen-activated protein kinase pathways.
Topics: Cell Adhesion Molecules; Cell Line; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; E-Selectin; Eikenella corrodens; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-8; KB Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Periodontitis; Phosphorylation; Pyridines; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A | 2007 |
Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes.
Topics: Bacterial Proteins; Butadienes; Cell Line; Chaperonin 60; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Helicobacter pylori; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; RNA, Small Interfering; Toll-Like Receptor 2; Transcription, Genetic | 2007 |
[Signaling pathways in expression of inducible nitric oxide synthase induced by high mobility group box 1 in rat alveolar macrophages].
Topics: Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HMGB1 Protein; Imidazoles; Macrophages, Alveolar; Male; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Proline; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Thiocarbamates | 2006 |
IL-13 mediates the recruitment of reserve cells for fusion during IGF-1-induced hypertrophy of human myotubes.
Topics: Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Hypertrophy; Imidazoles; Insulin-Like Growth Factor I; Interleukin-13; Membrane Fusion; Muscle Fibers, Skeletal; Pyridines | 2007 |
Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.
Topics: Apoptosis; Cycloheximide; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Profiling; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-4; Leupeptins; Neutrophils; Pyridines; Receptors, Interleukin-4, Type I; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship; Suppressor of Cytokine Signaling Proteins; Tyrphostins | 2007 |
Macrostemonoside A promotes visfatin expression in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cytokines; Flavonoids; Genes, Reporter; Imidazoles; Luciferases; Mice; Nicotinamide Phosphoribosyltransferase; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Saponins; Steroids; Transcription, Genetic; Transfection | 2007 |
cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.
Topics: Apoptosis; Butadienes; Carcinoma, Hepatocellular; CASP8 and FADD-Like Apoptosis Regulating Protein; Cathepsins; Cell Line, Tumor; Flavonoids; Humans; Imidazoles; Liver Neoplasms; Lysosomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Permeability; Protein Transport; Pyridines; TNF-Related Apoptosis-Inducing Ligand | 2007 |
Syk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathways.
Topics: Animals; Aorta; Becaplermin; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyridines; Rats; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; RNA, Small Interfering; Stilbenes; Syk Kinase; Transfection | 2007 |
P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus.
Topics: Animals; Blotting, Western; Flavonoids; Glutamic Acid; Hippocampus; Imidazoles; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Purinergic P2 Receptor Agonists; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 2007 |
Induction of the matrix metalloproteinase-2 activation system in arteries by tensile stress. Involvement of the p38 MAP-kinase pathway.
Topics: Animals; Arteries; Blotting, Western; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Imidazoles; Immunohistochemistry; MAP Kinase Signaling System; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Mechanotransduction, Cellular; Muscle, Smooth, Vascular; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Pressure; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical; Swine; Tensile Strength; Tissue Inhibitor of Metalloproteinase-2 | 2007 |
Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.
Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Cells, Cultured; Colon; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; GTP-Binding Protein alpha Subunit, Gi2; Imidazoles; Interleukin-11; Interleukin-1beta; Intestine, Small; Methyl Ethers; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2007 |
Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts.
Topics: Animals; Cell Death; Cell Hypoxia; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Flavonoids; Hydrogen-Ion Concentration; Imidazoles; Mice; Mitogen-Activated Protein Kinase 3; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Sodium-Hydrogen Exchangers; Transcription Factors | 2007 |
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
Topics: Blotting, Western; Calcium; Cell Line, Tumor; Cell Movement; Chemotaxis; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Lysophospholipids; Morpholines; Neoplasm Invasiveness; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine | 2007 |
Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren's syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity.
Topics: Animals; Autoimmunity; Catechin; Cell Line; Cell Survival; Disease Models, Animal; Flavonoids; Humans; Imidazoles; Lymphocytes; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mice; Mice, Inbred NOD; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Plant Extracts; Polyphenols; Pyridines; Salivary Glands; Sjogren's Syndrome; Tea; Tumor Necrosis Factor-alpha | 2007 |
Endothelin-1 induces contraction via a Syk-mediated p38 mitogen-activated protein kinase pathway in rat aortic smooth muscle.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Immunoprecipitation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Stilbenes; Syk Kinase; Vasoconstriction | 2007 |
Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling.
Topics: Animals; Cell Line; Cell Proliferation; Chromones; Colitis; Dextran Sulfate; Electroporation; Female; Flavonoids; Genetic Therapy; Hepatocyte Growth Factor; Imidazoles; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyridines; Regeneration; RNA, Small Interfering; Signal Transduction | 2007 |
Activation of intracellular signaling pathways is necessary for an increase in VDR expression and its nuclear translocation.
Topics: Active Transport, Cell Nucleus; Calcitriol; Cell Nucleus; Cells, Cultured; Chromones; Enzyme Inhibitors; Fatty Acids, Unsaturated; Flavonoids; Gene Expression Regulation; HL-60 Cells; Humans; Imidazoles; Leukemia; Models, Biological; Morpholines; Protein Biosynthesis; Pyridines; Receptors, Calcitriol; Signal Transduction | 2007 |
Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma.
Topics: Animals; Cells, Cultured; Collagenases; Corneal Stroma; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Flavonoids; Imidazoles; Interleukin-1alpha; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits; Signal Transduction; Wound Healing | 2007 |
Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway.
Topics: Anthracenes; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keloid; Low-Level Light Therapy; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Transcription Factor AP-1; Transforming Growth Factor beta1 | 2007 |
Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione.
Topics: Animals; Apoptosis; Caspase 3; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Enzyme Activation; Flavonoids; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Pyridines; Xenograft Model Antitumor Assays | 2007 |
Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anthracenes; Apoptosis; Astrocytoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dicumarol; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Ion Channels; JNK Mitogen-Activated Protein Kinases; Necrosis; Niflumic Acid; Nitrobenzoates; Osmolar Concentration; Pyridines; Rats; Taurine | 2007 |
Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12.
Topics: Animals; Butadienes; Cells, Cultured; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Imidazoles; Interleukin-12; Interleukin-4; Mast Cells; Mice; Morpholines; Nitriles; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Proteinase-Activated; RNA, Messenger; Trypsin; Tryptases; Tyrphostins | 2007 |
Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats.
Topics: Animals; Behavior, Animal; Body Weight; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Facial Pain; Flavonoids; Functional Laterality; Hyperalgesia; Imidazoles; Male; Physical Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Time Factors | 2007 |
Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits.
Topics: Aged; Angiotensin II; Cell Proliferation; Cells, Cultured; Connexin 43; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Insulin-Like Growth Factor I; Male; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents | 2007 |
Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.
Topics: Acetaldehyde; Animals; Anthracenes; Blotting, Western; Caspase 3; Cell Nucleus; Cells, Cultured; Ethanol; Flavonoids; Hepatocytes; Histones; Imidazoles; Male; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Serine | 2007 |
Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Flavonoids; Gardenia; Glioma; Glucosides; Imidazoles; Immunoblotting; Iridoid Glucosides; Iridoids; Keratolytic Agents; Masoprocol; Mitogen-Activated Protein Kinases; Molecular Structure; Nerve Growth Factor; NF-kappa B; Peptide Fragments; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor AP-1; Transcriptional Activation | 2007 |
Spleen tyrosine kinase participates in Src-mediated migration and proliferation by PDGF-BB in rat aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Becaplermin; Blotting, Western; Cell Movement; Cell Proliferation; Cells, Cultured; Diffusion Chambers, Culture; Enzyme Inhibitors; Flavonoids; Genes, src; Imidazoles; Immunoprecipitation; In Vitro Techniques; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyridines; Rats; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Spleen; Wound Healing | 2007 |
Oxidized low density lipoproteins induce apoptosis in human lymphocytes: involvement of mitogen-activated protein kinases.
Topics: Annexin A5; Apoptosis; Caspase 3; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Oxidative Stress; Pyridines; T-Lymphocytes; Time Factors | 2007 |
Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation.
Topics: Anthracenes; Apoptosis; Calcium Signaling; Caspase 3; Cell Line, Tumor; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Preservatives, Pharmaceutical; Protein Kinase Inhibitors; Pyridines; Stomach Neoplasms; Thimerosal; Time Factors | 2007 |
Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices.
Topics: Blotting, Western; Butadienes; Cell Line; Cell Proliferation; Cell Survival; Collagen Type I; Dose-Response Relationship, Drug; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Synthesis Inhibitors; Pyridines; Quinazolinones; Time Factors | 2007 |
Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death.
Topics: Caspase 3; Caspase 9; Cell Death; Enzyme Activation; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Flavonoids; Fulvestrant; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Estrogen; Tamoxifen; Time Factors | 2007 |
p38 mitogen-activated protein kinase contributes to angiotensin II-stimulated migration of rat aortic smooth muscle cells.
Topics: Actins; Angiotensin II; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Male; Mitogen-Activated Protein Kinase 1; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Stilbenes; Syk Kinase; Vasoconstrictor Agents | 2007 |
ICAM-1 and p38 MAPK mediate fibrinogen-induced migration of human vascular smooth muscle cells.
Topics: Abciximab; Antibodies, Blocking; Antibodies, Monoclonal; Cell Movement; Chemotaxis; Chromones; DNA; Enzyme Inhibitors; Fibrinogen; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Immunoglobulin Fab Fragments; Intercellular Adhesion Molecule-1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Pyridines | 2007 |
p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cells, Cultured; Chromans; Flavonoids; Hydrogen Peroxide; Imidazoles; Interleukin-10; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2007 |
Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line; Cells, Cultured; Chondrocytes; Chromones; Enzyme Induction; Enzyme Inhibitors; Enzymes; Flavonoids; Humans; Imidazoles; Interferon-gamma; Leptin; MAP Kinase Kinase 1; Morpholines; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Wortmannin | 2007 |
[Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line].
Topics: Anthracenes; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Enzyme Precursors; Factor VII; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Metalloendopeptidases; Pyridines; Thromboplastin | 2007 |
Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors.
Topics: Anthracenes; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Line, Tumor; Chromones; Drug Screening Assays, Antitumor; Drug Synergism; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Imidazoles; Leukemia; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; U937 Cells | 2008 |
Extracellular calcium-sensing receptor activation induces vitamin D receptor levels in proximal kidney HK-2G cells by a mechanism that requires phosphorylation of p38alpha MAPK.
Topics: Blotting, Western; Butadienes; Calcium; Cell Line; Extracellular Space; Flavonoids; Humans; Imidazoles; Immunoprecipitation; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Calcitriol; Receptors, Calcium-Sensing; RNA, Small Interfering; Signal Transduction | 2008 |
Epigallocatechin-3-O-gallate inhibits the angiotensin II-induced adhesion molecule expression in human umbilical vein endothelial cell via inhibition of MAPK pathways.
Topics: Angiotensin II; Catechin; Cell Membrane; Endothelial Cells; Enzyme Activation; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2007 |
Effects of the marine toxins okadaic acid and palytoxin on mussel phagocytosis.
Topics: Acrylamides; Animals; Antibodies; Cnidarian Venoms; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Marine Toxins; Mytilus; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pyridines; Temperature | 2008 |
TNF-alpha induction by Pseudomonas aeruginosa lipopolysaccharide or slime-glycolipoprotein in human monocytes is regulated at the level of Mitogen-activated Protein Kinase activity: a distinct role of Toll-like receptor 2 and 4.
Topics: Bacterial Proteins; Blotting, Western; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Monocytes; Phosphorylation; Protein Kinase Inhibitors; Pseudomonas aeruginosa; Pseudomonas Infections; Pyridines; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.
Topics: Adenine; Anthracenes; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cadaverine; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; HeLa Cells; Humans; Imidazoles; Isodon; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Polyenes; Polyunsaturated Alkamides; Pyridines; ras Proteins | 2007 |
Recombinant tissue metalloproteinase inhibitor-3 protein induces apoptosis of murine osteoblast MC3T3-E1.
Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Osteoblasts; Phosphorylation; Pyridines; Recombinant Proteins; Tissue Inhibitor of Metalloproteinase-3 | 2008 |
Mycoplasma genitalium-derived lipid-associated membrane proteins induce activation of MAPKs, NF-kappaB and AP-1 in THP-1 cells.
Topics: Anthracenes; Bacterial Proteins; Blotting, Western; DNA; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Monocytes; Mycoplasma genitalium; NF-kappa B; Protein Binding; Pyridines; Pyrrolidines; Thiocarbamates; Time Factors; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2008 |
Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epi
Topics: Actins; Animals; Base Sequence; Cell Differentiation; Cell Transdifferentiation; DNA Primers; Epithelial Cells; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Kidney Tubules, Proximal; LLC-PK1 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors; Pyridines; Rabbits; Rats; Recombinant Proteins; Signal Transduction; Smad Proteins; Swine; Transforming Growth Factor beta1 | 2008 |
Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes.
Topics: Cell Proliferation; Cells, Cultured; Dual-Specificity Phosphatases; Enzyme Inhibitors; Epidermal Cells; Epidermis; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Humans; Imidazoles; Keratinocytes; MAP Kinase Signaling System; Microarray Analysis; Microtubules; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription Factors; Transcription, Genetic | 2008 |
The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion.
Topics: Activating Transcription Factors; Blotting, Western; Cell Adhesion; Cells, Cultured; DNA, Complementary; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Integrin alpha4beta1; Intercellular Adhesion Molecule-1; Interleukin-8; Leukocytes; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Trypsin; Vascular Cell Adhesion Molecule-1 | 2008 |
Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells.
Topics: Anthracenes; Antioxidants; Apoptosis; Cell Line, Tumor; Central Nervous System Stimulants; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Methamphetamine; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Vitamin E | 2008 |
Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways.
Topics: Animals; Arachidonic Acid; Ascorbic Acid; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Embryonic Stem Cells; Flavonoids; G1 Phase; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation | 2008 |
Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway.
Topics: Animals; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Imidazoles; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides | 2008 |
[The role of mitogen-activated protein kinase cascades in inhibition of proliferation in human prostate carcinoma cells by raloxifene: an in vitro experiment].
Topics: Apoptosis; Blotting, Western; Bone Density Conservation Agents; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyridines; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2008 |
Cyclic mechanical stretch stimulates the proliferation of C2C12 myoblasts and inhibits their differentiation via prolonged activation of p38 MAPK.
Topics: Animals; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Proliferation; Flavonoids; Imidazoles; Male; MAP Kinase Kinase Kinase 3; Mechanotransduction, Cellular; Mice; Muscle Development; Myoblasts, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Stress, Mechanical | 2008 |
HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.
Topics: Adenosine Diphosphate; Blood Platelets; Cytoplasmic Granules; Flavonoids; Heat-Shock Proteins; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pyridines | 2008 |
Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.
Topics: Amino Acid Sequence; Anthracenes; Argonaute Proteins; Arsenites; Blotting, Western; Cell Line; Eukaryotic Initiation Factor-2; Flavonoids; Glutathione Transferase; Humans; Imidazoles; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mass Spectrometry; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Sodium Compounds | 2008 |
PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney.
Topics: Animals; Cells, Cultured; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kidney; Kidney Cortex; Male; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Specific Pathogen-Free Organisms | 2008 |
A role for IL-18 in human neutrophil apoptosis.
Topics: Apoptosis; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-18; Kinetics; Lipopolysaccharides; Morpholines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Propidium; Pyridines; Receptors, Interleukin-18; Signal Transduction | 2008 |
Neurotoxicity of cadmium on immature hippocampus and a neuroprotective role for p38 MAPK.
Topics: Animals; Animals, Newborn; Cadmium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Hippocampus; Imidazoles; In Vitro Techniques; Male; Neurotoxins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tetrazolium Salts; Thiazoles | 2008 |
Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells.
Topics: Allyl Compounds; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation; Cell Shape; Cell Survival; Disulfides; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; HL-60 Cells; Humans; Imidazoles; Leukemia, Promyelocytic, Acute; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Time Factors | 2008 |
TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.
Topics: Anthracenes; Antigens, CD; B7-H1 Antigen; Carcinoma, Transitional Cell; Cell Line, Tumor; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharide Receptors; Lipopolysaccharides; MAP Kinase Signaling System; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyridines; Toll-Like Receptor 4; Up-Regulation; Urinary Bladder Neoplasms | 2008 |
Lysophosphatidylcholine up-regulates human endothelial nitric oxide synthase gene transactivity by c-Jun N-terminal kinase signalling pathway.
Topics: Blotting, Western; Cell Line; DNA Probes; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Flavonoids; Green Fluorescent Proteins; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lysophosphatidylcholines; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase Type III; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Pyridines; Signal Transduction; Sp1 Transcription Factor; Transcription Factor AP-1; Transcriptional Activation; Up-Regulation | 2009 |
Adiponectin enhances in vitro development of swine embryos.
Topics: Adiponectin; Animals; Butadienes; Embryonic Development; Female; Flavonoids; Imidazoles; Immunohistochemistry; Male; MAP Kinase Signaling System; Meiosis; Mitogen-Activated Protein Kinases; Nitriles; Oocytes; Parthenogenesis; Pregnancy; Protein Kinase Inhibitors; Pyridines; Receptors, Adiponectin; Reverse Transcriptase Polymerase Chain Reaction; RNA; Swine | 2008 |
Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1/2) signaling pathways.
Topics: Chemokine CCL20; Flavonoids; Humans; Imidazoles; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, G-Protein-Coupled; Serum Amyloid A Protein; Signal Transduction | 2008 |
PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation.
Topics: Benzoquinones; Cell Differentiation; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Activation; Female; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pregnancy; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyridines; Pyrimidines; Rifabutin; Signal Transduction; src-Family Kinases; Trophoblasts | 2008 |
Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling.
Topics: Anthracenes; Base Sequence; Cell Line, Tumor; Chromones; Cytochrome P450 Family 7; Elafin; Enzyme Activation; Estradiol; Estrogens; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Molecular Sequence Data; Morpholines; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Pyridines; Steroid Hydroxylases | 2008 |
Effect of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Chromones; Collagen; Electromagnetic Fields; Equipment Design; Flavonoids; Imidazoles; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction | 2008 |
Interferon-gamma priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages.
Topics: Animals; Anthracenes; Antiviral Agents; Arginase; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GC Rich Sequence; Imidazoles; Interferon-gamma; Interleukin-10; Interleukin-12; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Oligodeoxyribonucleotides; p38 Mitogen-Activated Protein Kinases; Pyridines; Up-Regulation | 2009 |
Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38.
Topics: Cell Growth Processes; Endocrine Disruptors; Enzyme Activation; Enzyme Inhibitors; Estrogens; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Estrogen; Response Elements; Signal Transduction; Tumor Cells, Cultured | 2009 |
ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells.
Topics: Apoptosis; Cytochromes c; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Melatonin; Mitochondria; Monocytes; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Radiation Tolerance; Signal Transduction; U937 Cells; Ultraviolet Rays | 2009 |
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Topics: Animals; Anthracenes; Binding Sites; Carcinoma; Cell Line; Cell Line, Tumor; Cottontail rabbit papillomavirus; Disease Models, Animal; DNA Mutational Analysis; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Rabbits; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Viral Proteins | 2009 |
Oxidized LDL affects smooth muscle cell growth through MAPK-mediated actions on nuclear protein import.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Atherosclerosis; Cell Nucleus; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Lipoproteins, LDL; MAP Kinase Signaling System; Membrane Glycoproteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Pore Complex Proteins; p38 Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Pyridines; Rabbits | 2009 |
CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways.
Topics: Basement Membrane; Blotting, Western; Cells, Cultured; Connective Tissue Growth Factor; Extracellular Matrix Proteins; Fibronectins; Flavonoids; Humans; Imidazoles; Immunoenzyme Techniques; Laminin; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Proteins; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2009 |
Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.
Topics: Anthracenes; Anti-Inflammatory Agents; Benzophenanthridines; Cell Line; Curcumin; Enzyme Activation; Epithelial Cells; Esophagus; Flavonoids; Humans; Hydrogen-Ion Concentration; Imidazoles; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinases; Mucous Membrane; NF-kappa B; Peptides; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Telomerase; Time Factors; Transcription, Genetic; Up-Regulation | 2009 |
High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells.
Topics: Cell Adhesion; Cells, Cultured; Chemokine CCL2; Chemokine CX3CL1; Clofibrate; Fenofibrate; Flavonoids; Glucose; Humans; I-kappa B Proteins; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR alpha; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Pyridines; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Up-Regulation | 2008 |
Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells.
Topics: Animals; Catechin; Cattle; Caveolin 1; Down-Regulation; Endothelium, Vascular; Flavonoids; Imidazoles; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Tea | 2009 |
Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells.
Topics: Anthracenes; Cell Line; Chromones; Colforsin; Corticotropin-Releasing Hormone; Dexamethasone; Flavonoids; Genes, Reporter; Humans; Hypothalamus; Imidazoles; Isoquinolines; Morpholines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Regulatory Elements, Transcriptional; Sequence Deletion; Sulfonamides; Transfection | 2008 |
Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts.
Topics: Anthracenes; Blotting, Western; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Flavonoids; Humans; Imidazoles; Infant, Newborn; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; Plant Growth Regulators; Pyridines; Skin; Ultraviolet Rays; Zeatin | 2009 |
Telmisartan, an angiotensin II type 1 receptor antagonist, attenuates T-type Ca2+ channel expression in neonatal rat cardiomyocytes.
Topics: Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Benzimidazoles; Benzoates; Calcium Channels, T-Type; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Extracellular Signal-Regulated MAP Kinases; F-Box Proteins; Flavonoids; Gene Expression Regulation; Heart Rate; Imidazoles; JNK Mitogen-Activated Protein Kinases; Membrane Potentials; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Telmisartan; Tetrazoles; Time Factors; Valine; Valsartan; Zebrafish Proteins | 2009 |
17beta-Estradiol-induced enhancement of estrogen receptor biosynthesis via MAPK pathway in mouse skeletal muscle myoblasts.
Topics: Animals; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Flavonoids; Fulvestrant; Imidazoles; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Animal; Muscle, Skeletal; Myoblasts, Skeletal; Pyridines; Receptors, Estrogen; Signal Transduction; Tamoxifen | 2009 |
Differential effects of MAPKs signaling on the growth of invasive bladder cancer cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Transitional Cell; Cell Cycle; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; Immunoenzyme Techniques; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2009 |
NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells.
Topics: Allopurinol; Anthracenes; Blotting, Western; Cadmium; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Liver; NADPH Oxidases; Onium Compounds; Phosphorylation; Potassium Cyanide; Pyridines; Signal Transduction; STAT3 Transcription Factor; Sulfones | 2009 |
Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Arecoline; Cheek; Cholinergic Agonists; Connective Tissue Growth Factor; Curcumin; Endothelial Cells; Epithelial Cells; Fibroblasts; Flavonoids; Humans; Imidazoles; Mouth Mucosa; Nitriles; Oral Submucous Fibrosis; Pyridines; Sulfones | 2009 |
Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Hyaluronic Acid; Imidazoles; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Oligosaccharides; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Pyridines; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2009 |
Scratch wound closure of C2C12 mouse myoblasts is enhanced by human platelet lysate.
Topics: Androstadienes; Animals; Blood Platelets; Cell Line; Cell Movement; Chemotaxis; Complex Mixtures; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Mice; Myoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Wortmannin; Wound Healing | 2009 |
Biphasic effect of cadmium on cell proliferation in human embryo lung fibroblast cells and its molecular mechanism.
Topics: Anthracenes; Cadmium; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines | 2009 |
Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.
Topics: Acetaminophen; Animals; Anthracenes; Cell Line; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Indomethacin; Interleukin-1beta; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mice; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction; Theophylline; Tumor Necrosis Factor-alpha | 2009 |
PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering.
Topics: Amino Acid Substitution; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Adhesion; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Foreskin; Humans; Imidazoles; Infant, Newborn; Keratinocytes; Kidney; Male; Protein Kinase C-delta; Pyridines; RNA, Small Interfering; Tight Junctions | 2009 |
Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.
Topics: Adenosine Diphosphate; Anticoagulants; Antithrombin III; Blood Platelets; CD40 Ligand; Enzyme Inhibitors; Flavonoids; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Mitogen-Activated Protein Kinase 3; Molecular Chaperones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Pyridines; Secretory Vesicles; Serotonin | 2009 |
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene.
Topics: Binding Sites; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; Histones; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Serine; Signal Transduction; Sp1 Transcription Factor; T-Box Domain Proteins; Tetradecanoylphorbol Acetate | 2009 |
Differential inhibition of single and cluster type tumor cell migration.
Topics: Adolescent; Bone Neoplasms; Cell Culture Techniques; Cell Movement; Cell Proliferation; Chromones; Deoxyuridine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Flavonoids; Humans; Imidazoles; Male; Morpholines; Okadaic Acid; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Tumor Cells, Cultured | 2009 |
Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression.
Topics: Adaptor Proteins, Signal Transducing; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kidney Neoplasms; Leupeptins; Mitogen-Activated Protein Kinase 8; p38 Mitogen-Activated Protein Kinases; Proteasome Inhibitors; Pyridines; Signal Transduction | 2009 |
Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent.
Topics: Analysis of Variance; Animals; Anthracenes; Blotting, Western; Cells, Cultured; Early Growth Response Protein 1; Enzyme Inhibitors; Female; Flavonoids; Gonadotropin-Releasing Hormone; Imidazoles; JNK Mitogen-Activated Protein Kinases; Luteinizing Hormone, beta Subunit; Male; MAP Kinase Kinase 1; Neoplasm Proteins; Phosphorylation; Pituitary Gland; Pyridines; Rats; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2009 |
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Topics: Androstadienes; Anthracenes; Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Genistein; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Uterine Cervical Neoplasms; Wortmannin | 2009 |
Receptor-mediated vascular smooth muscle migration induced by LPA involves p38 mitogen-activated protein kinase pathway activation.
Topics: Animals; Cell Movement; Cells, Cultured; Diphosphates; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycerol; Imidazoles; Lysophospholipids; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid | 2009 |
The effects of ERK1/2 inhibitor on the chondrogenesis of bone marrow- and adipose tissue-derived multipotent mesenchymal stromal cells.
Topics: Adipose Tissue; Adult; Bone Marrow Cells; Cell Count; Chondrogenesis; Collagen; DNA; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Immunohistochemistry; Mesenchymal Stem Cells; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multipotent Stem Cells; Protein Kinase Inhibitors; Proteoglycans; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells; Transcription Factors | 2010 |
Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs.
Topics: Animals; Anthracenes; Bacterial Outer Membrane Proteins; Butadienes; Cell Adhesion Molecules; Cell Survival; Cronobacter sakazakii; Dendritic Cells; Enterobacteriaceae Infections; Enzyme Inhibitors; Epithelial Cells; Flavonoids; HeLa Cells; Humans; Imidazoles; Interleukin-10; Lectins, C-Type; Lipopolysaccharides; Lymphocyte Activation; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase Kinases; Nitriles; Pyridines; Rats; Receptors, Cell Surface; Transfection; Transforming Growth Factor beta | 2009 |
CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia.
Topics: Amyloid beta-Peptides; Animals; Cell Line; Chemokines, CC; Chloroquine; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Flow Cytometry; Imidazoles; Macrophage Inflammatory Proteins; Macrophages; Mice; Microglia; Mitogen-Activated Protein Kinases; Myeloid Differentiation Factor 88; Oligodeoxyribonucleotides; Peptide Fragments; Pyridines; Receptors, CCR1; Reverse Transcriptase Polymerase Chain Reaction; Toll-Like Receptor 9; Transfection; Up-Regulation | 2010 |
HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products.
Topics: Animals; Anthracenes; Arthritis, Experimental; Cytokines; Enzyme Inhibitors; Female; Flavonoids; Glycation End Products, Advanced; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Toll-Like Receptor 2; Toll-Like Receptor 4; Up-Regulation | 2009 |
The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes.
Topics: Anthracenes; Bone Marrow Cells; Cells, Cultured; Child; Child, Preschool; Female; Flavonoids; Humans; Imidazoles; Infant; Leukemia Inhibitory Factor; Male; Myelodysplastic Syndromes; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Serum; Stromal Cells | 2010 |
Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC.
Topics: Caco-2 Cells; Chemokine CXCL10; Dexamethasone; Epithelial Cells; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glucocorticoids; HT29 Cells; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Intestines; NF-kappa B; Nitriles; Pyridines; Pyrrolidines; Receptors, Glucocorticoid; RNA, Messenger; Sulfones; Thiocarbamates | 2010 |
Ligand-independent activation of the androgen receptor by insulin-like growth factor-I and the role of the MAPK pathway in skeletal muscle cells.
Topics: Active Transport, Cell Nucleus; Animals; Anthracenes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Insulin-Like Growth Factor I; Ligands; MAP Kinase Kinase 4; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Androgen; Signal Transduction | 2009 |
Astaxanthin inhibits H2O2-mediated apoptotic cell death in mouse neural progenitor cells via modulation of P38 and MEK signaling pathways.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase Inhibitors; Cell Culture Techniques; Enzyme Inhibitors; Flavonoids; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; Mice; Oxidants; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Spinal Cord; Stem Cells; Xanthophylls | 2009 |
Adipocyte-mononuclear cell interaction, Toll-like receptor 4 activation, and high glucose synergistically up-regulate osteopontin expression via an interleukin 6-mediated mechanism.
Topics: Adipocytes; Antibodies; Cell Communication; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression; Glucose; Humans; Imidazoles; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Osteopontin; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Toll-Like Receptor 4; Transcription Factor AP-1; U937 Cells | 2010 |
Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras-MKK3-p38 to regulate in vitro cellular invasion.
Topics: Animals; Blotting, Western; Cell Adhesion; Cell Movement; Flavonoids; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Profiling; Imidazoles; MAP Kinase Kinase 3; Mice; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Pyridines; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2010 |
p38 inhibitor intensified cell death in antimycin A-treated As4.1 juxtaglomerular cells via the enhancement of GSH depletion.
Topics: Animals; Antimycin A; Cell Cycle; Cell Death; Cell Growth Processes; Cell Line, Tumor; Flavonoids; Glutathione; Imidazoles; Juxtaglomerular Apparatus; Kidney Neoplasms; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species | 2009 |
Nitric oxide stimulates interleukin-6 production in skeletal myotubes.
Topics: Animals; Cell Line; Cyclic GMP; Flavonoids; Imidazoles; Immunization; Interleukin-6; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Muscle Fibers, Skeletal; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Quinoxalines; Up-Regulation | 2010 |
Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer.
Topics: Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme Activation; Flavonoids; Gene Expression Regulation, Enzymologic; Hepatocyte Growth Factor; Humans; Imidazoles; Kisspeptins; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Pyridines; Stomach Neoplasms; Tumor Suppressor Proteins | 2009 |
The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease.
Topics: Adenoviridae; Colitis, Ulcerative; Colon; Complement C3; Crohn Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Interleukin-17; Intestinal Mucosa; Male; Mitogen-Activated Protein Kinase 1; Mutation; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transduction, Genetic | 2010 |
Glucocorticoid rapidly enhances NMDA-evoked neurotoxicity by attenuating the NR2A-containing NMDA receptor-mediated ERK1/2 activation.
Topics: Animals; Blotting, Western; Calcium; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Hippocampus; Imidazoles; Mifepristone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; p38 Mitogen-Activated Protein Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways.
Topics: Anthracenes; Apoptosis; Blotting, Western; Caspase 3; Cells, Cultured; Endothelial Cells; Flavonoids; Flow Cytometry; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Palmitic Acid; Pyridines; Stem Cells; Up-Regulation | 2010 |
VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chromones; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mice; Morpholines; Neuroendocrine Tumors; Octreotide; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Sirolimus; Somatostatin; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2010 |
Cyclic stretch induces proliferation and TGF-beta1-mediated apoptosis via p38 and ERK in ureteric bud cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Mice; Mice, Transgenic; p38 Mitogen-Activated Protein Kinases; PAX2 Transcription Factor; Pyridines; Signal Transduction; Stress, Mechanical; Time Factors; Transforming Growth Factor beta1; Ureter; Ureteral Obstruction | 2010 |
Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages.
Topics: Animals; Anthracenes; Apoptosis; Cell Line; Cell Nucleus; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorescence Resonance Energy Transfer; Helicobacter Infections; Helicobacter pylori; Host-Pathogen Interactions; Imidazoles; Immunoblotting; Macromolecular Substances; Macrophages; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1 | 2010 |
Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.
Topics: Cell Line, Tumor; Chemokine CCL2; Cholesterol 7-alpha-Hydroxylase; Dextran Sulfate; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fucose; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Ketocholesterols; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Periodontitis; Polysaccharides; Pyridines; Receptors, Scavenger; Sulfuric Acid Esters | 2010 |
Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Dual Specificity Phosphatase 1; Flavonoids; Gene Knockdown Techniques; Glucosephosphate Dehydrogenase; Hep G2 Cells; Humans; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases; Pyridines | 2010 |
Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-kappaB in peripheral blood mononuclear cells.
Topics: Animals; Anti-Inflammatory Agents; Bacopa; Betulinic Acid; Cells, Cultured; Flavonoids; Humans; Imidazoles; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Male; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Pyridines; Rats; Rats, Wistar; Signal Transduction; Triterpenes | 2010 |
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.
Topics: Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Gene Regulatory Networks; Hepatocyte Growth Factor; Humans; Imidazoles; Ligands; Lysophospholipids; Mammary Glands, Human; Phosphorylation; Pyridines; Quinazolines; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha | 2010 |
Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.
Topics: Adult; Anticoagulants; Bone Neoplasms; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Male; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Osteoblasts; Osteocalcin; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Protein Kinase Inhibitors; Pyridines; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sulfonamides; Vitamin K; Vitamins; Warfarin; Young Adult | 2010 |
Proinflammatory effects of muramyldipeptide on human gingival fibroblasts.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adult; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemokine CCL2; Chemokine CXCL10; Chemokine CXCL11; Chromones; Chronic Periodontitis; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Gingiva; Humans; Imidazoles; Inflammation Mediators; Interferon-gamma; Interleukin-6; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Morpholines; Nod2 Signaling Adaptor Protein; Periodontal Attachment Loss; Periodontal Pocket; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Tumor Necrosis Factor-alpha | 2010 |
Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.
Topics: Animals; Calcium; Carbazoles; Cattle; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Growth Cones; Humans; Imidazoles; Ion Channel Gating; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nicotine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-alpha; Pyridines; Receptors, Nicotinic; Sodium Channels; tau Proteins; Tetrodotoxin; Time Factors; Veratridine | 2010 |
Treatment with p38 inhibitor partially prevents Calu-6 lung cancer cell death by a proteasome inhibitor, MG132.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Proliferation; Cysteine Proteinase Inhibitors; Flavonoids; Glutathione; Humans; Imidazoles; Leupeptins; Lung Neoplasms; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Tumor Cells, Cultured | 2010 |
Oral malodorous compound induces osteoclast differentiation without receptor activator of nuclear factor κB ligand.
Topics: Acid Phosphatase; Animals; Blotting, Western; Calcium Phosphates; Calcium-Calmodulin-Dependent Protein Kinases; Cathepsin K; Cell Differentiation; Cell Line; Enzyme Inhibitors; Flavonoids; Halitosis; Hydrogen Sulfide; Imidazoles; Isoenzymes; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RANK Ligand; Tartrate-Resistant Acid Phosphatase | 2010 |
Negative modulation of invariant natural killer T cell responses to glycolipid antigens by p38 MAP kinase.
Topics: Animals; Anthracenes; Antibodies; Antigen Presentation; Antigens; Antigens, CD1d; CD3 Complex; Cytokines; Down-Regulation; Enzyme Inhibitors; Flavonoids; Galactosylceramides; Imidazoles; Interferon-gamma; Interleukin-2; Interleukin-4; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Antigen, T-Cell; Spleen | 2010 |
Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells.
Topics: Animals; Bone Morphogenetic Protein 4; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle Cells; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells | 2010 |
Vasoactive intestinal peptide induces vascular endothelial growth factor production in human HaCaT keratinocytes via MAPK pathway.
Topics: Blotting, Western; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vascular Endothelial Growth Factor A; Vasoactive Intestinal Peptide | 2010 |
Osteogenic responses of human mesenchymal stromal cells to static stretch.
Topics: Alkaline Phosphatase; Biomechanical Phenomena; Bone Morphogenetic Protein 2; Cell Count; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Dexamethasone; Flavonoids; Glucocorticoids; Humans; Imidazoles; Insulin-Like Growth Factor I; Mesoderm; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; Nitric Oxide; Osteoblasts; Osteogenesis; Osteogenesis, Distraction; p38 Mitogen-Activated Protein Kinases; Pyridines; Stress, Mechanical; Stromal Cells; Time Factors; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2010 |
Parathyroid hormone(1-34)-induced apoptosis in neuronal rat PC12 cells: implications for neurotoxicity.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Death; Cell Survival; Cytochromes c; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Imidazoles; L-Lactate Dehydrogenase; Mitochondria; p38 Mitogen-Activated Protein Kinases; Parathyroid Hormone; PC12 Cells; Pyridines; Rats; Signal Transduction; Time Factors; Up-Regulation | 2010 |
Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase 3; Caspase 7; Caspase 9; Cell Line, Tumor; Cyclosporins; Cytochromes c; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Pyridines; Reactive Oxygen Species; U937 Cells | 2011 |
Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (-)-Epigallocatechin gallate via ERK MAP kinase pathway.
Topics: Catechin; Cells, Cultured; Chromones; Connexin 43; Culture Media, Serum-Free; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gap Junctions; Humans; Imidazoles; Morpholines; NG-Nitroarginine Methyl Ester; Pyridines; RNA, Small Interfering; Signal Transduction | 2011 |
[VEGF promotes the proliferation of bone marrow derived mesenchymal stem cells through ERK1/2 signal pathway].
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Mesenchymal Stem Cells; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factors | 2010 |
High glucose induces enhanced expression of resistin in human U937 monocyte-like cell line by MAPK- and NF-kB-dependent mechanisms; the modulating effect of insulin.
Topics: Cell Line; Dose-Response Relationship, Drug; Flavonoids; Glucose; Humans; Imidazoles; Insulin; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Pyridines; Resistin; U937 Cells; Up-Regulation | 2011 |
[Role of MAPK in the migration of human coronary artery smooth muscle cell into three-dimensional fibrin gel].
Topics: Anthracenes; Cell Movement; Cells, Cultured; Coronary Vessels; Extracellular Signal-Regulated MAP Kinases; Fibrin; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Pyridines | 2005 |
Pulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow.
Topics: Atherosclerosis; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Pulsatile Flow; Pyridines; Stress, Mechanical; Thrombin; Thromboplastin | 2011 |
Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury.
Topics: Actin Cytoskeleton; Animals; Anthracenes; Burns; Chemokine CCL2; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; P-Selectin; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Tight Junctions | 2011 |
Angiotensin II induces the expression of c-reactive protein via MAPK-dependent signal pathway in U937 macrophages.
Topics: Acetylcysteine; Angiotensin II; Antihypertensive Agents; C-Reactive Protein; Flavonoids; Humans; Imidazoles; Losartan; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Pyridines; Thiocarbamates; U937 Cells | 2011 |
Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801.
Topics: 4-Butyrolactone; Animals; Cell Line; Chromones; Erythropoietin; Flavonoids; Gene Expression Regulation; Glucose; Imidazoles; L-Lactate Dehydrogenase; Male; Morpholines; Neurons; Oxygen; Plasmids; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Repressor Proteins; Transcription Factors | 2011 |
Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes.
Topics: 14-3-3 Proteins; Anthracenes; Biomarkers, Tumor; Blotting, Western; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Dermis; Exonucleases; Exoribonucleases; Fibroblasts; Flavonoids; Gene Expression Profiling; Humans; Imidazoles; Keratinocytes; MAP Kinase Signaling System; Pyridines; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells.
Topics: Adult; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Insulin; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovary; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Progesterone; Pyridines; Young Adult | 2011 |
All-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells.
Topics: Cell Line, Tumor; Flavonoids; Flow Cytometry; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Protein Kinase Inhibitors; Pyridines; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tretinoin | 2011 |
Insulin-mediated upregulation of K(Ca)3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Flavonoids; Imidazoles; Insulin; Intermediate-Conductance Calcium-Activated Potassium Channels; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2011 |
Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.
Topics: Anthracenes; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; Flavonoids; GPI-Linked Proteins; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mitogen-Activated Protein Kinases; Neoplasms; Promoter Regions, Genetic; Protein Binding; Pyridines; Response Elements; RNA, Messenger; Signal Transduction | 2011 |
Genipa americana (Rubiaceae) fruit extract affects mitogen-activated protein kinase cell pathways in human trophoblast-derived BeWo cells: implications for placental development.
Topics: Adenosine Monophosphate; Cell Differentiation; Cell Line; Cell Proliferation; Chorionic Gonadotropin; Dimethyl Sulfoxide; Drug Evaluation; Female; Flavonoids; Fluorescent Antibody Technique; Fruit; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Placentation; Plant Extracts; Pregnancy; Pyridines; Rubiaceae; Signal Transduction; Trophoblasts | 2011 |
Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Benzamides; Flavonoids; Flow Cytometry; Imatinib Mesylate; Imidazoles; Melanoma, Experimental; Membrane Potentials; Mice; Mitochondria; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Reactive Oxygen Species | 2011 |
c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anthracenes; Aorta; Dexmedetomidine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Male; Muscle Contraction; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Protein Isoforms; Pyridines; Rats; Rats, Sprague-Dawley | 2011 |
Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase.
Topics: Blotting, Western; Cell Membrane; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; NADPH Oxidases; Neutrophils; Nicotinamide Phosphoribosyltransferase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Subunits; Protein Transport; Pyridines; Reactive Oxygen Species; Respiratory Burst; Threonine | 2011 |
Berberine acutely activates the glucose transport activity of GLUT1.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Biological Transport; Cell Line; Deoxyglucose; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Glucose; Glucose Transporter Type 1; Imidazoles; Kinetics; Mice; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Pyrimidines | 2011 |
AGE-BSA down-regulates endothelial connexin43 gap junctions.
Topics: Animals; Cattle; Cells, Cultured; Connexin 43; Down-Regulation; Endothelial Cells; Flavonoids; Gap Junctions; Glycation End Products, Advanced; Humans; Imidazoles; MAP Kinase Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serum Albumin, Bovine; Signal Transduction | 2011 |
Defective nuclear translocation of stress-activated signaling in senescent diploid human fibroblasts: a possible explanation for aging-associated apoptosis resistance.
Topics: Apoptosis; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cellular Senescence; Child, Preschool; Diploidy; Fibroblasts; Flavonoids; Foreskin; Humans; Hydrogen Peroxide; Imidazoles; Interphase; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyridines; Staurosporine; Stress, Physiological; Wheat Germ Agglutinins | 2011 |
Effects of downregulation of aquaporin1 by peptidoglycan and lipopolysaccharide via MAPK pathways in MeT-5A cells.
Topics: Anthracenes; Aquaporin 1; Cell Line; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Peptidoglycan; Pyridines; Staphylococcus aureus | 2011 |
Peroxisome proliferator-activated receptor γ (PPARγ) plays a critical role in the development of TGFβ resistance of H460 cell.
Topics: Anilides; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunoprecipitation; Mitogen-Activated Protein Kinases; PPAR gamma; Protein Binding; Pyridines; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Trypan Blue | 2011 |
Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
Topics: Animals; Biomarkers; Bone Morphogenetic Proteins; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Flavones; Flavonoids; Glucosides; Imidazoles; MAP Kinase Signaling System; Mesenchymal Stem Cells; Models, Biological; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2011 |
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.
Topics: Apolipoprotein A-I; Apolipoproteins; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cells, Cultured; Cholesterol; Cyclooxygenase 2; Down-Regulation; Drug Synergism; Epoprostenol; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Nonesterified; Flavonoids; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Janus Kinase 2; Lipoproteins, HDL; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phospholipids; Phosphorylation; Protein Kinase Inhibitors; Pyridines; RNA, Small Interfering; Signal Transduction; Sphingosine; Trypsin; Tyrphostins; Up-Regulation | 2011 |
High calcium, ATP, and poly(I:C) augment the immune response to β-glucan in normal human epidermal keratinocytes.
Topics: Adenosine Triphosphate; beta-Glucans; Calcium; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Immunity, Innate; Interleukin-1alpha; Interleukin-6; Interleukin-8; Keratinocytes; Lectins, C-Type; Membrane Proteins; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Poly I-C; Pyridines; Signal Transduction | 2011 |
Panax notoginseng saponins promote osteogenic differentiation of bone marrow stromal cells through the ERK and P38 MAPK signaling pathways.
Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Integrin-Binding Sialoprotein; Male; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Panax notoginseng; Phosphorylation; PPAR gamma; Pyridines; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Stromal Cells | 2011 |
Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides.
Topics: Aggrecans; Animals; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Chromones; Collagen Type II; Drug Therapy, Combination; Endopeptidases; Flavonoids; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Hyaluronan Receptors; Hyaluronic Acid; Imidazoles; Lactones; Morpholines; Oligosaccharides; Pyridines; Sesquiterpenes, Eudesmane; Signal Transduction; Viscosupplements | 2012 |
Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells.
Topics: Animals; Benzamides; Cell Line; Collagen; Cyclin D1; Dioxoles; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gefitinib; Imidazoles; Kidney; MAP Kinase Signaling System; Mice; Mitosis; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Rats; Receptors, Transforming Growth Factor beta; Smad Proteins; Transforming Growth Factor beta1; Translational Research, Biomedical | 2011 |
ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.
Topics: Cell Line; Cell Survival; Curcumin; Diethylhexyl Phthalate; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-8; MAP Kinase Signaling System; Medicine, Chinese Traditional; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger | 2012 |
On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats.
Topics: Animals; Benzylamines; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ganglia, Spinal; Imidazoles; Immunohistochemistry; Male; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Posterior Horn Cells; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides | 2011 |
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Ethanol; Flavonoids; Flowers; Genetic Vectors; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Morpholines; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Protein Transport; Prunella; Pyridines; Sepsis; Signal Transduction; Transfection | 2012 |
Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1β-stimulated human gingival fibroblasts.
Topics: Blotting, Western; Cells, Cultured; Chemokine CCL20; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gingiva; Humans; I-kappa B Kinase; Imidazoles; Interleukin-17; Interleukin-1beta; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Interleukin-17; Signal Transduction; Thiophenes | 2012 |
Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia.
Topics: Butadienes; Cell Line, Tumor; Cell Survival; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Humans; Imidazoles; Immunoblotting; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-E2-Related Factor 2; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pre-Eclampsia; Pregnancy; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2011 |
Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism.
Topics: Animals; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Hepatocytes; I-kappa B Proteins; Imidazoles; Insulin; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Morpholines; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Plasmids; Proto-Oncogene Proteins c-akt; Pyridines; Rats | 2012 |
p38 mitogen-activated protein kinase is a key regulator of 5-phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine-induced apoptosis in human HL-60 cells.
Topics: Apoptosis; Caspase 2; Caspase 3; Caspase 8; Deoxyuridine; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Organoselenium Compounds; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Pyridines; Reactive Oxygen Species | 2012 |
Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells.
Topics: Apoptosis; Blotting, Western; Butadienes; Cytomegalovirus; Cytomegalovirus Infections; DNA Primers; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Genetic Vectors; Humans; Imidazoles; Lentivirus; Myeloid Cell Leukemia Sequence 1 Protein; Myeloid Cells; Nitriles; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Viral Envelope Proteins; Virus Internalization | 2012 |
Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells.
Topics: Anthracenes; Endothelial Cells; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Nicotine; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species; Receptors, Urokinase Plasminogen Activator; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor AP-1 | 2012 |
miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene.
Topics: Anthracenes; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-8; Lipopolysaccharides; MAP Kinase Signaling System; MicroRNAs; NF-kappa B; Nuclear Receptor Co-Repressor 2; Pyridines; Transcription, Genetic; Transcriptional Activation; U937 Cells | 2012 |
Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.
Topics: Animals; Anthracenes; Cell Line, Transformed; Cicatrix; Collagen Type I; Connective Tissue Growth Factor; Cornea; Corneal Stroma; Enzyme Activation; Eye Injuries, Penetrating; Fibroblasts; Fibronectins; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Phosphorylation; Pyridines; Rats; Rats, Wistar; Telomerase; Transforming Growth Factor beta1; Wound Healing | 2012 |
S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.
Topics: Animals; Diabetic Nephropathies; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Glucose; Hyperglycemia; Imidazoles; Kidney; Lysophospholipids; MAP Kinase Signaling System; Mesangial Cells; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sphingosine; Sphingosine-1-Phosphate Receptors | 2012 |
EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts.
Topics: Anthracenes; Benzamides; Catechin; Cell Line; Cells, Cultured; Connective Tissue Growth Factor; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; MAP Kinase Kinase 4; Mouth Mucosa; Oral Submucous Fibrosis; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2013 |
Regulation of cytokine and chemokine expression by the ribotoxic stress response elicited by Shiga toxin type 1 in human macrophage-like THP-1 cells.
Topics: Anthracenes; Cell Line, Tumor; Chemokines; Cytokines; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Macrophages; Mitogen-Activated Protein Kinase Kinases; Pyridines; Shiga Toxin 1; Stress, Physiological; Time Factors | 2012 |
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.
Topics: Animals; Chemotaxis, Leukocyte; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G-Protein-Coupled Receptor Kinase 2; HEK293 Cells; HL-60 Cells; Humans; Imidazoles; Mice; Mice, Knockout; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Formyl Peptide; Signal Transduction | 2012 |
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxygenase 2 Inhibitors; Down-Regulation; Female; Flavonoids; Gene Expression; Gene Expression Regulation, Neoplastic; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Male; Middle Aged; Mouth Neoplasms; Nitrobenzenes; Pyridines; Quercetin; Sulfonamides | 2012 |
Cockroach allergen Per a 7 down-regulates expression of Toll-like receptor 9 and IL-12 release from P815 cells through PI3K and MAPK signaling pathways.
Topics: Allergens; Animals; Blotting, Western; Butadienes; Cell Line, Tumor; Chromones; Cockroaches; Down-Regulation; Flavonoids; Flow Cytometry; Gene Expression Regulation; Imidazoles; Insect Proteins; Interleukin-12; MAP Kinase Signaling System; Mast Cells; Mice; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Recombinant Proteins; RNA, Messenger; Time Factors; Toll-Like Receptor 9 | 2012 |
Mitogen-activated protein kinase pathways are involved in the upregulation of calcitonin gene-related peptide of rat trigeminal ganglion after organ culture.
Topics: Animals; Anthracenes; Calcitonin Gene-Related Peptide; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Migraine Disorders; Neurons; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trigeminal Ganglion; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways.
Topics: Adrenal Gland Neoplasms; Animals; Anthracenes; Apoptosis; Brain-Derived Neurotrophic Factor; Carrier Proteins; Cell Line, Tumor; Cell Survival; Cycloheximide; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HEK293 Cells; Homer Scaffolding Proteins; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pheochromocytoma; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2012 |
Up-regulation of IL-23 p19 expression in human periodontal ligament fibroblasts by IL-1β via concurrent activation of the NF-κB and MAPKs/AP-1 pathways.
Topics: Anthracenes; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Interleukin-23 Subunit p19; JNK Mitogen-Activated Protein Kinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factor AP-1; Transcription Factor RelA; Up-Regulation | 2012 |
Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens.
Topics: Animals; Antigens, Bacterial; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cytokines; Enzyme Inhibitors; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Flavonoids; Herpesvirus 1, Human; Humans; Imidazoles; Immunization; Lipid Metabolism; Lipids; Macrophage Activation; Macrophages; Mice; Mitogen-Activated Protein Kinases; Monocytes; Peptides; Pyridines; Viral Envelope Proteins | 2012 |
Different roles of peripheral mitogen-activated protein kinases in carrageenan-induced arthritic pain and arthritis in rats.
Topics: Animals; Anthracenes; Arthritis, Experimental; Carrageenan; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley | 2012 |
Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.
Topics: Aged; Cartilage, Articular; Cells, Cultured; Chondrocytes; Drug Interactions; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Flavonoids; Gene Expression; Humans; Imidazoles; Immunosuppressive Agents; Lysophospholipids; Male; Mitogen-Activated Protein Kinases; Osteoarthritis; Pertussis Toxin; Propylene Glycols; Pyridines; RNA, Messenger; Sphingosine; Vascular Endothelial Growth Factor A | 2012 |
Effects of vascular endothelial cells on osteogenic differentiation of noncontact co-cultured periodontal ligament stem cells under hypoxia.
Topics: Adult; Alkaline Phosphatase; Animals; Calcification, Physiologic; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Core Binding Factor Alpha 1 Subunit; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Periodontal Ligament; Pyridines; Sp7 Transcription Factor; Stem Cells; Transcription Factors; Vascular Endothelial Growth Factor A | 2013 |
Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells.
Topics: Cell Line, Tumor; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, PAR-2; RNA, Messenger; Stomach Neoplasms; Trypsin; Vascular Endothelial Growth Factors | 2012 |
Hyperglycemia suppresses cardiac stem cell homing to peri-infarcted myocardium via regulation of ERK1/2 and p38 MAPK activities.
Topics: Animals; Cell Movement; Cells, Cultured; Diabetes Mellitus, Experimental; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Hyperglycemia; Imidazoles; Male; MAP Kinase Signaling System; Myocardial Infarction; Myocardium; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Rats; Rats, Sprague-Dawley; Stem Cell Factor; Stem Cells; Ventricular Pressure | 2012 |
Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Case-Control Studies; CD40 Ligand; Diabetes Mellitus, Type 2; Female; Flavonoids; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Molecular Chaperones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Protein Processing, Post-Translational; Pyridines; Serine | 2012 |
Upregulation of macrophage-specific functions by oxidized LDL: lysosomal degradation-dependent and -independent pathways.
Topics: Acetylcysteine; Cell Differentiation; Cells, Cultured; Chloroquine; Chromones; Copper Sulfate; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression; Humans; Imidazoles; Leukocytes, Mononuclear; Lipoproteins, LDL; Lysosomes; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; Naphthalenes; NF-kappa B; Oxidation-Reduction; PPAR gamma; Proteolysis; Pyridines; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation; Up-Regulation | 2013 |
Bone morphogenetic protein-9 induces osteogenic differentiation of rat dental follicle stem cells in P38 and ERK1/2 MAPK dependent manner.
Topics: Alkaline Phosphatase; Animals; Calcium; Cell Differentiation; Cells, Cultured; Dental Sac; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Growth Differentiation Factor 2; Imidazoles; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Stem Cells | 2012 |
Interleukin-8 stimulates progesterone production via the MEK pathway in ovarian theca cells.
Topics: Actins; Animals; Cattle; Cells, Cultured; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Interleukin-8; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Progesterone; Pyridines; RNA, Messenger; Theca Cells | 2013 |
The upregulation of transglutaminase-2 by cyclosporin a in human gingival fibroblasts is augmented by oxidative stress.
Topics: Acetylcysteine; Adult; Antioxidants; Catechin; Cell Culture Techniques; Cells, Cultured; Chromones; Curcumin; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Free Radical Scavengers; Gingiva; GTP-Binding Proteins; Humans; Imidazoles; Immunosuppressive Agents; Male; Morpholines; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protease Inhibitors; Protein Glutamine gamma Glutamyltransferase 2; Pyridines; Reactive Oxygen Species; Transglutaminases; Up-Regulation | 2013 |
Nitric oxide activates IL-6 production and expression in human renal epithelial cells.
Topics: Anthracenes; Epithelial Cells; Escherichia coli Infections; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kidney; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA Stability; RNA, Messenger | 2012 |
KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin | 2013 |
p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation.
Topics: Animals; Cell Survival; Cells, Cultured; Cytokine Receptor gp130; Flavonoids; Humans; Hypertrophy; Imidazoles; Interleukin-6; Janus Kinases; Leukemia Inhibitory Factor; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; Receptors, Erythropoietin; Recombinant Fusion Proteins; Recombinant Proteins; Reperfusion Injury; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor | 2013 |
Effects of interleukin-1β and tumor necrosis factor-α on macrophage inflammatory protein-3α production in synovial fibroblast-like cells from human temporomandibular joints.
Topics: Adolescent; Adult; Anthracenes; Cell Culture Techniques; Chemokine CCL20; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Gene Expression Profiling; Humans; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Joint Dislocations; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Synovial Membrane; Temporomandibular Joint Disorders; Time Factors; Tumor Necrosis Factor-alpha; Young Adult | 2013 |
S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
Topics: Animals; Calgranulin B; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Hep G2 Cells; Humans; Imidazoles; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Transplantation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Random Allocation; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays | 2013 |
P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.
Topics: Animals; Anthracenes; Cartilage, Articular; Cattle; Cell Dedifferentiation; Cell Proliferation; Cell Survival; Chondrocytes; Chondrogenesis; Extracellular Matrix; Flavonoids; Gene Expression; Glycosaminoglycans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phenotype; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines | 2013 |
Endothelin-1 stimulates the expression of L-type Ca2+ channels in neonatal rat cardiomyocytes via the extracellular signal-regulated kinase 1/2 pathway.
Topics: Animals; Animals, Newborn; Anthracenes; Blotting, Western; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Oligopeptides; Patch-Clamp Techniques; Peptides, Cyclic; Piperidines; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2013 |
Salmonella enhance chemosensitivity in tumor through connexin 43 upregulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Therapy; Cell Communication; Cell Line, Tumor; Cisplatin; Connexin 43; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gap Junctions; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA Interference; RNA, Small Interfering; Salmonella; Up-Regulation | 2013 |
Insulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein α.
Topics: Acetyl-CoA C-Acetyltransferase; CCAAT-Enhancer-Binding Protein-alpha; Cell Line; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Response Elements; Signal Transduction | 2013 |
Curcumin inhibits TGFβ1-induced CCN2 via Src, JNK, and Smad3 in gingiva.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Catechin; Cell Culture Techniques; Cell Movement; Cells, Cultured; Connective Tissue Growth Factor; Curcumin; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gingiva; Gingival Overgrowth; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Lovastatin; MAP Kinase Kinase 4; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Smad3 Protein; src-Family Kinases; Transforming Growth Factor beta1 | 2013 |
Immune complexes activate human endothelium involving the cell-signaling HMGB1-RAGE axis in the pathogenesis of lupus vasculitis.
Topics: Antigen-Antibody Complex; Cell Survival; Cytokines; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HMGB1 Protein; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Lupus Vasculitis, Central Nervous System; Monocytes; Nitriles; Pyridines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Signal Transduction; Sulfones; Transcription Factor RelA; Transendothelial and Transepithelial Migration; U937 Cells; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2013 |
Endothelin-1 stimulates proinflammatory cytokine expression in human periodontal ligament cells via mitogen-activated protein kinase pathway.
Topics: Adult; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Female; Flavonoids; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Periodontal Ligament; Periodontitis; Piperidines; Pyridines; Time Factors; Tumor Necrosis Factor-alpha | 2014 |
TLR4 Signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation.
Topics: Animals; Anthracenes; Bone Marrow Cells; Cell Movement; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G-Protein-Coupled Receptor Kinase 2; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Immunological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, CCR2; RNA Interference; RNA, Small Interfering; Toll-Like Receptor 4 | 2013 |
(-)-Epigallocatechin-3-gallate inhibits CC chemokine ligand 11 production in human gingival fibroblasts.
Topics: Anthracenes; Catechin; Cells, Cultured; Chemokine CCL11; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-4; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Th2 Cells; Tumor Necrosis Factor-alpha | 2013 |
Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase.
Topics: Cell Line; Flavonoids; Humans; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Tryptases; Urothelium | 2013 |
Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway.
Topics: Alanine Transaminase; Animals; Anthracenes; Aspartate Aminotransferases; Carbon Monoxide; Ethanol; Flavonoids; Glutathione; Heme Oxygenase-1; Hepatocytes; Imidazoles; Interleukin-6; L-Lactate Dehydrogenase; Liver Diseases, Alcoholic; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Organometallic Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phytochemicals; Pyridines; Quercetin; Rats; Tumor Necrosis Factor-alpha | 2013 |
RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Imidazoles; Lung; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Mutation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Sheep | 2013 |
[Effects of phosphorylated mitogen-activated protein kinases on phosgene inhalation-induced lung injury in rats and its relationship with matrix metalloproteinase].
Topics: Animals; Burns, Inhalation; Cytokines; Disease Models, Animal; Flavonoids; Imidazoles; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Phosgene; Phosphorylation; Pyridines; Rats; Rats, Wistar | 2013 |
Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60.
Topics: Adenosine Triphosphate; Anthracenes; Antioxidants; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Histones; HL-60 Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Promyelocytic, Acute; M Phase Cell Cycle Checkpoints; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species | 2013 |
EGF enhances ADSCs secretion via ERK and JNK pathways.
Topics: Adipose Tissue; Adult; Anthracenes; Chemokine CXCL12; Culture Media, Conditioned; Epidermal Growth Factor; Female; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Lipectomy; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stem Cells; Vascular Endothelial Growth Factor A | 2014 |
Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics.
Topics: Animals; Blotting, Western; Bone Regeneration; Calcium Compounds; Cell Line; Ceramics; Endothelial Growth Factors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; Silicates; Strontium | 2013 |
Involvement of MAPK signaling pathway in the osteogenic gene expressions of Cervi Pantotrichum Cornu in MG-63 human osteoblast-like cells.
Topics: Alkaline Phosphatase; Animals; Anthracenes; Antlers; Blotting, Western; Calcium; Cell Line; Collagen; Deer; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Male; MAP Kinase Signaling System; Osteoblasts; Osteogenesis; Pyridines; Real-Time Polymerase Chain Reaction | 2014 |
Inhibition of KCa3.1 suppresses TGF-β1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways.
Topics: Cells, Cultured; Chemokine CCL2; Flavonoids; Gene Knockdown Techniques; Humans; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Kidney Tubules, Proximal; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrazoles; Pyridines; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Transfection; Transforming Growth Factor beta1 | 2014 |
Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK.
Topics: Anthracenes; Apoptosis; Benzothiazoles; Caspase 3; Caspase 9; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Diterpenes, Kaurane; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase Cell Cycle Checkpoints; Humans; Imidazoles; Isodon; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Plant Preparations; Pyridines; RNA, Messenger; Toluene; Tumor Suppressor Protein p53 | 2014 |
Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Caspase 8; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Chalcones; Chromatin; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; Fas Ligand Protein; Flavonoids; Humans; Imidazoles; KB Cells; Keratinocytes; Mouth Neoplasms; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2014 |
A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation.
Topics: Acrocephalosyndactylia; Animals; Cell Differentiation; Embryonic Development; Flavonoids; Gene Knock-In Techniques; Humans; Imidazoles; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mutation; Osteogenesis; Phosphorylation; Pyridines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Up-Regulation | 2014 |
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult | 2014 |
Osteoblastic differentiation of stromal ST-2 cells from octacalcium phosphate exposure via p38 signaling pathway.
Topics: Alkaline Phosphatase; Androstadienes; Animals; Calcium Phosphates; Cell Differentiation; Cell Line; Cell Proliferation; Flavonoids; Imidazoles; Mice; Molecular Structure; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stromal Cells; Wortmannin | 2014 |
Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells.
Topics: Anthracenes; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Quercetin; TRPM Cation Channels | 2014 |
Pentraxin 3 promotes oxLDL uptake and inhibits cholesterol efflux from macrophage-derived foam cells.
Topics: Apolipoprotein A-I; Atherosclerosis; ATP Binding Cassette Transporter 1; C-Reactive Protein; Cell Line, Tumor; Cholesterol; Chromones; Flavonoids; Foam Cells; Gene Expression; Gene Silencing; Humans; Imidazoles; Lipoproteins, LDL; Liver X Receptors; Mitogen-Activated Protein Kinase 3; Morpholines; Orphan Nuclear Receptors; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; PPAR gamma; Pyridines; Serum Amyloid P-Component; Signal Transduction | 2014 |
API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Flavonoids; HCT116 Cells; HeLa Cells; Humans; Imidazoles; Lymphocyte Activation; MCF-7 Cells; Membrane Proteins; Mice; Morpholines; Neoplasms; Nuclear Proteins; Protein Kinase C-delta; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines; Receptor, Fibroblast Growth Factor, Type 1; RNA Interference; Signal Transduction; Tumor Escape | 2014 |
Lipopolysaccharide-regulated production of bone sialoprotein and interleukin-8 in human periodontal ligament fibroblasts: the role of toll-like receptors 2 and 4 and the MAPK pathway.
Topics: Adolescent; Calcification, Physiologic; Cell Culture Techniques; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Knockdown Techniques; Humans; Imidazoles; Integrin-Binding Sialoprotein; Interleukin-8; Lipopolysaccharides; MAP Kinase Signaling System; Periodontal Ligament; Porphyromonas gingivalis; Protein Kinase Inhibitors; Pyridines; RNA, Small Interfering; Toll-Like Receptor 2; Toll-Like Receptor 4; Young Adult | 2015 |
Involvement of p38 mitogen-activated protein kinase in acquired gemcitabine-resistant human urothelial carcinoma sublines.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Flavonoids; Gemcitabine; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Urinary Bladder Neoplasms | 2014 |
Advanced glycation end products increase expression of S100A8 and A9 via RAGE-MAPK in rat dental pulp cells.
Topics: Animals; Antibodies; Calgranulin A; Calgranulin B; Cells, Cultured; Dental Pulp; Diabetes Mellitus; Flavonoids; Gene Expression; Glycation End Products, Advanced; Imidazoles; Interleukin-1beta; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Pyridines; Rats; Receptor for Advanced Glycation End Products; RNA, Messenger | 2015 |
Bone morphogenetic protein-9 induces PDLSCs osteogenic differentiation through the ERK and p38 signal pathways.
Topics: Adolescent; Alkaline Phosphatase; Cell Differentiation; Cells, Cultured; Child; Core Binding Factor Alpha 1 Subunit; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Growth Differentiation Factor 2; Humans; Imidazoles; Immunohistochemistry; Osteocalcin; Osteogenesis; Osteopontin; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Pyridines; Stem Cells | 2014 |
Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts.
Topics: 3T3 Cells; Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Down-Regulation; Fibroblast Growth Factor 2; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Proteins; Resveratrol; Stilbenes | 2014 |
Mechanism of tissue factor production by monocytes stimulated with neutrophil elastase.
Topics: Calcium Channel Blockers; Carbazoles; Enzyme Inhibitors; Estrenes; Flavonoids; Gallic Acid; Gene Expression Regulation; Humans; Imidazoles; Indoles; Leukocyte Elastase; Maleimides; Monocytes; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; RNA, Messenger; Signal Transduction; Thromboplastin; Type C Phospholipases | 2015 |
Pyroglutamic acid stimulates DNA synthesis in rat primary hepatocytes through the mitogen-activated protein kinase pathway.
Topics: Animals; Cells, Cultured; Chromatography, Liquid; DNA; Female; Flavonoids; Hepatocytes; Humans; Imidazoles; Male; MAP Kinase Signaling System; Mass Spectrometry; Placenta; Pregnancy; Protein Kinase Inhibitors; Pyridines; Pyrrolidonecarboxylic Acid; Rats, Sprague-Dawley | 2015 |
Interleukin-18 enhances breast cancer cell migration via down-regulation of claudin-12 and induction of the p38 MAPK pathway.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Claudin-1; Claudin-3; Claudin-4; Claudins; Down-Regulation; Female; Flavonoids; Gene Knockdown Techniques; Humans; Imidazoles; Interleukin-18; MAP Kinase Signaling System; MCF-7 Cells; Protein Kinase Inhibitors; Pyridines; Recombinant Proteins; RNA, Small Interfering; Tight Junctions | 2015 |
[Calf blood hemodializate reduces neurotoxic effect of hydrogen peroxide on human neuroblastoma cells].
Topics: Animals; Apoptosis; Cattle; Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase 4; Neuroblastoma; Neurotoxicity Syndromes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Pyridines; Reactive Oxygen Species; Renal Dialysis; Signal Transduction | 2014 |
Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Flavonoids; Imidazoles; MAP Kinase Kinase Kinases; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
MFG-E8 inhibits neutrophil migration through αvβ₃-integrin-dependent MAP kinase activation.
Topics: Antibodies, Neutralizing; Antigens, Surface; Cell Line, Tumor; Cell Movement; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; G-Protein-Coupled Receptor Kinase 2; HL-60 Cells; Humans; Imidazoles; Integrin alphaVbeta3; Interleukin-8; Milk Proteins; Neutrophil Infiltration; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Interleukin-8B; Receptors, Vitronectin | 2015 |
Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation.
Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type IV; Dose-Response Relationship, Drug; Extracellular Matrix; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mesangial Cells; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction; Transforming Growth Factor beta1 | 2015 |
Mechanism of interleukin-13 production by granulocyte-macrophage colony-stimulating factor-dependent macrophages via protease-activated receptor-2.
Topics: Butadienes; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Differentiation; Dose-Response Relationship, Drug; Flavonoids; Gallic Acid; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-13; Leukocyte Elastase; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Naphthalenes; Nitriles; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Receptor, PAR-2; Signal Transduction | 2015 |
Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.
Topics: Alkaloids; Animals; Bone Marrow Cells; Cell Division; Cells, Cultured; Chromones; Colony-Forming Units Assay; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Inbred CBA; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2015 |
Regulatory Roles of Endogenous Mitogen-Activated Protein Kinases and Tyrosine Kinases in the Pacemaker Activity of Colonic Interstitial Cells of Cajal.
Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin | 2015 |
HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-κB activation.
Topics: Acute-Phase Proteins; Cell Line; Cell Proliferation; Chromones; Flavonoids; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Imidazoles; Lipocalin-2; Lipocalins; Matrix Metalloproteinase 9; Morpholines; Neoplasm Metastasis; NF-kappa B; Proto-Oncogene Proteins; Pyridines; Signal Transduction; Stomach Neoplasms | 2015 |
The Roles of p38 MAPK and ERK1/2 in Coplanar Polychlorinated Biphenyls-Induced Apoptosis of Human Extravillous Cytotrophoblast-Derived Transformed Cells.
Topics: Apoptosis; Carrier Proteins; Cell Line, Transformed; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Silencing; Humans; Imidazoles; MAP Kinase Signaling System; Mitochondrial Proteins; p38 Mitogen-Activated Protein Kinases; Polychlorinated Biphenyls; Pyridines; Trophoblasts | 2015 |
Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways.
Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioma; Hydrogen Sulfide; Imidazoles; MAP Kinase Signaling System; Nitrobenzenes; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Rats; Sulfonamides | 2015 |
Interleukin (IL)-1β Is a Strong Inducer of IL-36γ Expression in Human Colonic Myofibroblasts.
Topics: Blotting, Western; Butadienes; Cells, Cultured; Colon; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Microscopy, Confocal; Myofibroblasts; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factor AP-1; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2015 |
Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions.
Topics: Animals; Chromones; Erythropoiesis; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hematopoietic Stem Cells; Imidazoles; Immunomagnetic Separation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2015 |
PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.
Topics: Animals; Becaplermin; Cell Line; Fibroblasts; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-sis; Pyridines; Rats; Repressor Proteins; STAT1 Transcription Factor | 2016 |
The MAPK pathway is involved in the regulation of rapid pacing-induced ionic channel remodeling in rat atrial myocytes.
Topics: Animals; Atrial Fibrillation; Calcium Channels, L-Type; Cells, Cultured; Female; Flavonoids; Heart Atria; Imidazoles; MAP Kinase Signaling System; Myocytes, Cardiac; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Shal Potassium Channels | 2016 |
Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats.
Topics: Action Potentials; Animals; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Flavonoids; Foot; Imidazoles; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroglia; p38 Mitogen-Activated Protein Kinases; Pain, Postoperative; Posterior Horn Cells; Pyridines; Rats, Sprague-Dawley; Up-Regulation | 2016 |
Production of CCL20 from lung cancer cells induces the cell migration and proliferation through PI3K pathway.
Topics: A549 Cells; Cell Movement; Cell Proliferation; Chemokine CCL20; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Interleukin-1beta; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction | 2016 |
Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Topics: Acute Lung Injury; Animals; Anthracenes; Apoptosis; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Uncoupling Protein 2 | 2016 |
Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Movement; Diabetes Complications; Flavonoids; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hyperglycemia; Imidazoles; MAP Kinase Signaling System; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Pyridines; Reactive Oxygen Species; Resveratrol; Stilbenes | 2016 |
Proliferation in cardiac fibroblasts induced by β1-adrenoceptor autoantibody and the underlying mechanisms.
Topics: Actins; Amino Acid Sequence; Animals; Animals, Newborn; Autoantibodies; Cell Line; Cell Proliferation; Echocardiography; Endomyocardial Fibrosis; Fibroblasts; Flavonoids; Gene Expression Regulation; Imidazoles; Immunization, Passive; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Pyridines; Rats; Receptors, Adrenergic, beta-1; Signal Transduction | 2016 |
Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.
Topics: Anemia; Animals; Bone Marrow Cells; Chromones; Disease Models, Animal; Erythropoiesis; Erythropoietin; Flavonoids; Gene Expression Regulation; Hemorrhage; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2016 |
MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells.
Topics: Acetylation; Animals; Butadienes; Cell Differentiation; Flavonoids; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mice; Models, Biological; Muscle Development; Muscle Fibers, Skeletal; Myosin Heavy Chains; Nitriles; Nuclear Proteins; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Stem Cells; Theophylline | 2017 |
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Flavonoids; Hyperalgesia; Imidazoles; MAP Kinase Signaling System; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Nociception; Pain; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Spinal Cord | 2017 |
Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells.
Topics: Apoptosis; Autophagy; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrans; Pyridines; Reactive Oxygen Species; TOR Serine-Threonine Kinases | 2017 |
Intermittent low dose irradiation enhances the effectiveness of radio- and chemo-therapy for human colorectal adenocarcinoma cell line HT-29.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Benzothiazoles; Cell Proliferation; Chemoradiotherapy; Colorectal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorouracil; HT29 Cells; Humans; Imidazoles; MAP Kinase Signaling System; Morpholines; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrones; Radiation Dosage; Toluene; Tumor Suppressor Protein p53 | 2017 |
Icaritin induces MC3T3-E1 subclone14 cell differentiation through estrogen receptor-mediated ERK1/2 and p38 signaling activation.
Topics: Animals; Cell Differentiation; Cell Line; Cell Survival; Clone Cells; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Estrogen | 2017 |
Blocking the ERK1/2 signal pathway can inhibit S100A12 induced human aortic smooth muscle cells damage.
Topics: Aorta; Apoptosis; Cell Proliferation; Cells, Cultured; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase Inhibitors; Pyridines; S100A12 Protein | 2017 |
Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-α by Macrophages.
Topics: Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Histones; Imidazoles; Inflammation Mediators; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Pyridines; RAW 264.7 Cells; Recombinant Proteins; Signal Transduction; Thiocarbamates; Thioctic Acid; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2017 |
Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts.
Topics: Animals; Anthracenes; Becaplermin; Cell Line; Cell Movement; Flavonoids; HSP27 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyridines; Sirolimus | 2017 |
Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt.
Topics: Animals; Anthracenes; Cell Movement; Cells, Cultured; Epidermal Growth Factor; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Resveratrol; rho-Associated Kinases; Sirtuin 1; Stilbenes | 2017 |
Differentiation of human umbilical cord Wharton's jelly-derived mesenchymal stem cells into endometrial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; CD13 Antigens; Cell Differentiation; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Endometrium; Epithelial Cells; Estradiol; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Insulin-Like Growth Factor Binding Protein 1; Intercellular Signaling Peptides and Proteins; Isoquinolines; Keratins; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Primary Cell Culture; Prolactin; Pyridines; Signal Transduction; Stromal Cells; Sulfonamides; Tetraspanin 29; Umbilical Cord; Vimentin; Wharton Jelly | 2017 |
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Body Weight; Bone Morphogenetic Protein 4; Carrier Proteins; Chronic Disease; Disease Models, Animal; Endothelium, Vascular; Flavonoids; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; In Vitro Techniques; Kidney; Male; Nitric Oxide Synthase Type III; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats, Sprague-Dawley; Surgical Instruments; Systole; Vasodilation | 2018 |
Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner.
Topics: Anthracenes; Autocrine Communication; Axitinib; Butadienes; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Membrane Proteins; Nitriles; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2019 |
Role of Signaling Molecules in the Regulation of Granulocytopoiesis during Stress-Inducing Stimulation.
Topics: Animals; Bone Marrow Cells; Chromones; Flavonoids; Gene Expression Regulation; Gold Sodium Thiomalate; Granulocyte Colony-Stimulating Factor; Granulocytes; Imidazoles; Immobilization; Leukopoiesis; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Psychological | 2019 |
Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts.
Topics: Amiodarone; Anti-Arrhythmia Agents; Cell Differentiation; Cell Proliferation; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Lung; MAP Kinase Signaling System; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Pyridines | 2019 |
Role of MAPK ERK1/2 and p38 in the Realization of Growth Potential of Various Types of Regeneration-Competent Cells in Mouse Neural Tissue during Ethanol-Induced Neurodegeneration In Vitro.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Ethanol; Flavonoids; Imidazoles; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neural Stem Cells; p38 Mitogen-Activated Protein Kinases; Pyridines | 2019 |
Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF-κB pathway in glioblastoma cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Imidazoles; Myxovirus Resistance Proteins; Neoplasm Invasiveness; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Pyridines; Signal Transduction; Thiocarbamates | 2019 |
Floridoside Exhibits Antioxidant Properties by Activating HO-1 Expression via p38/ERK MAPK Pathway.
Topics: Antioxidants; Cell Line; Cell Survival; Flavonoids; Glycerol; Heme Oxygenase-1; Hepatocytes; Humans; Imidazoles; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; Pyridines; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2020 |
The mechanism of Mitogen-Activated Protein Kinases to mediate apoptosis and immunotoxicity induced by Benzo[a]pyrene on hemocytes of scallop Chlamys farreri in vitro.
Topics: Animals; Anthracenes; Apoptosis; Benzo(a)pyrene; Enzyme Inhibitors; Flavonoids; Hemocytes; Imidazoles; Mitogen-Activated Protein Kinases; Pectinidae; Phosphorylation; Pyridines | 2020 |
Peculiarities of the Involvement of MAPKS ERK1/2 and р38 in the Implementation of the Functions of Neural Stem Cells and Neuronal Committed Precursors in Ethanol-Induced Neurodegeneration.
Topics: Animals; Cell Cycle; Cell Differentiation; Ethanol; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurodegenerative Diseases; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stem Cells | 2020 |
Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients.
Topics: Adult; Anthracenes; Cells, Cultured; Chemokines, CXC; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation; Granulosa Cells; Humans; Imidazoles; Phosphoproteins; Polycystic Ovary Syndrome; Progesterone; Progesterone Reductase; Pyridines | 2021 |
Exosomes From Packed Red Cells Induce Human Mast Cell Activation and the Production of Multiple Inflammatory Mediators.
Topics: Adolescent; Adult; Anthracenes; Blood Donors; Blood Transfusion; Cell Line; Cell Survival; Erythrocytes; Exosomes; Flavonoids; Humans; Imidazoles; Immunity, Innate; Inflammation Mediators; Male; MAP Kinase Signaling System; Mast Cells; Middle Aged; Mitogen-Activated Protein Kinases; Pyridines; Toll-Like Receptor 3; Young Adult | 2021 |
HGF-mediated Up-regulation of PHLDA2 Is Associated With Apoptosis in Gastric Cancer.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hepatocyte Growth Factor; Humans; Imidazoles; Morpholines; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Pyridines; Stomach Neoplasms; Up-Regulation | 2021 |
Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration.
Topics: Animals; Astrocytes; Culture Media, Conditioned; Disease Models, Animal; Ethanol; Flavonoids; Gene Expression Regulation; Imidazoles; Mice; Mice, Inbred C57BL; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Growth Factors; Neurodegenerative Diseases; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Spheroids, Cellular | 2021 |