pd 98059 and piperidines

pd 98059 has been researched along with piperidines in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (11.11)	18.2507
2000's	24 (66.67)	29.6817
2010's	8 (22.22)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Beltman, J; Cadwallader, K; Cook, S; McCormick, F	1
Ballinger, CA; Dumont, JA; Horaist, C; Hu, Z; Meshel, AS; Patterson, C; Ruef, J; Subbarao, VD; Thompson, LJ	1
Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T	1
De Petrocellis, L; Di Marzo, V; Galve-Roperh, I; Guzmán, M; Melck, D; Rueda, D	1
Araki, M; Fujita, M; Hasegawa, K; Iwai-Kanai, E; Kakita, T; Morimoto, T; Sasayama, S; Sawamura, T; Wada, H	1
Díaz-Laviada, I; Ruiz, L; Sánchez, MG; Velasco, L	1
Aragona, F; Malendowicz, LK; Nussdorfer, GG; Rebuffat, P; Tortorella, C	1
Brune, K; Hinz, B; Pahl, A; Ramer, R	1
Bishop, WR; Brassard, DL; English, JM; Kirschmeier, P; Malkowski, M; Nagabhushan, TL	1
Balkwill, FR; Grimshaw, MJ; Wilson, JL	1
Albanese, C; D'Amico, M; Lee, RJ; Mani, S; Pestell, RG; Wang, C; Wu, K	1
Carbone, JM; Crawford, RB; Kaminski, NE; Ouyang, Y; Rummel, AM; Trosko, JE; Upham, BL	1
Díaz-Laviada, I; Ruiz-Llorente, L; Sánchez, AM; Sánchez, MG	1
Capuano, V; Coulombe, A; Deroubaix, E; Ferron, L; Renaud, JF; Ruchon, Y	1
Han, H; Long, H; Wang, H; Wang, J; Wang, Z; Xu, D; Zhang, Y	1
Slomiany, A; Slomiany, BL	2
Benetti, E; Collino, M; Dianzani, C; Fantozzi, R; Gallicchio, M; Rosa, AC	1
Kumar, A; Njie, YF; Qiao, Z; Song, ZH; Zhong, L	1
Iwakawa, T; Matsumoto, M; Nagata, K; Talkahashi, K; Uwabe, K	1
Su, JY; Vo, AC	1
Chu, TS; Hsieh, BS; Wu, KD; Wu, MS	1
Farge, D; Mauviel, A; Michel, L; Tacheau, C; Verrecchia, F	1
Bonanno, A; Ferraro, M; Gjomarkaj, M; Montalbano, AM; Pieper, MP; Pompeo, F; Profita, M; Riccobono, L; Siena, L	1
Akaike, A; Fujii, T; Kume, T; Niidome, T; Ohgi, Y; Sugimoto, H; Takada-Takatori, Y	1
He, F; Njie, YF; Qiao, Z; Song, ZH	1
Dean, WL; Lominadze, D; Patibandla, PK; Roberts, AM; Sen, U; Tyagi, N; Tyagi, SC	1
Ishida, K; Kamata, K; Kobayashi, T; Matsumoto, T; Nakayama, N	1
Huang, Y; Li, Y; Lopes-Virella, MF; Schuyler, CA; Ta, NN	1
Abdel-Rahman, AA; Ibrahim, BM	1
Hearing, VJ; Kawaguchi, M; Namiki, T; Suzuki, T; Valencia, JC	1
Chen, G; Dohi, S; Iida, H; Kawasaki, Y; Tanabe, K; Yanagidate, F; Zhang, L	1
Cheng, M; Li, M; Meng, W; She, T; Shi, C; Wang, B; Yu, L	1
E, LL; Liang, L; Liu, H; Liu, N; Wang, DS; Yu, J; Zhou, W	1
Hinz, B; Peters, K; Ramer, R; Salamon, A; Schmuhl, E	1
Chang, HH; Huang, YM; Juan, CC; Kao, CC; Kao, YH; Kuo, YC; Liu, CW; Tang, YC	1

Other Studies

36 other study(ies) available for pd 98059 and piperidines

Article	Year
Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells. The Biochemical journal, 1997, Feb-01, Volume: 321 ( Pt 3) Topics: Animals; Anisomycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Endothelins; Enzyme Activation; Flavonoids; Gene Expression Regulation; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lysophospholipids; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; Peptides, Cyclic; Pertussis Toxin; Piperidines; Protein Kinase C; Rats; Receptors, Endothelin; Signal Transduction; Virulence Factors, Bordetella	1997
Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat. Circulation, 1999, Aug-10, Volume: 100, Issue:6 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Cycle; Cell Division; Cells, Cultured; Cyclin-Dependent Kinases; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Growth Inhibitors; Humans; Hyperplasia; Male; Muscle Proteins; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Thrombin; Tumor Necrosis Factor-alpha; Tunica Intima; Wound Healing	1999
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase. The American journal of physiology, 1999, Volume: 277, Issue:6 Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine	1999
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. FEBS letters, 1999, Dec-17, Volume: 463, Issue:3 Topics: Arachidonic Acids; Breast Neoplasms; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Endocannabinoids; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Piperidines; Polyunsaturated Alkamides; Prolactin; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Prolactin; Rimonabant; Tumor Cells, Cultured	1999
Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes. Journal of the American College of Cardiology, 2000, Volume: 36, Issue:4 Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Anti-Bacterial Agents; Apoptosis; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Heart; Indoles; Isoproterenol; Myocardium; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sirolimus	2000
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1. European journal of biochemistry, 2001, Volume: 268, Issue:3 Topics: Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Male; Nerve Growth Factor; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella	2001
Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex. International journal of molecular medicine, 2001, Volume: 7, Issue:3 Topics: Adenine; Androstadienes; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Hydrocortisone; Indomethacin; Naphthalenes; Nifedipine; Oligopeptides; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase C; Pyrazoles; Pyrrolidinones; Receptors, Endothelin; Signal Transduction; Type C Phospholipases; Tyrphostins; Wortmannin; Zona Fasciculata; Zona Reticularis	2001
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism. Biochemical and biophysical research communications, 2001, Sep-07, Volume: 286, Issue:5 Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella	2001
Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras. Experimental cell research, 2002, Feb-15, Volume: 273, Issue:2 Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Butadienes; Cell Line; Cell Line, Transformed; Enzyme Inhibitors; Fibroblasts; Flavonoids; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Piperidines; Protein Prenylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Pyridines; Rats	2002
Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. European journal of immunology, 2002, Volume: 32, Issue:9 Topics: Bacterial Proteins; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Hypoxia; Cell Line; Chemokines, CXC; Chemotactic Factors; Chemotaxis; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Enzyme Inhibitors; Female; Flavonoids; Humans; Macrophage Activation; Macrophages; MAP Kinase Signaling System; Membrane Proteins; Monocytes; Neoplasm Proteins; Oligopeptides; Peptides, Cyclic; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Structure-Activity Relationship	2002
Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways. Molecular cancer therapeutics, 2002, Volume: 1, Issue:9 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Division; Cell Separation; Chromones; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Mitogen-Activated Protein Kinases; Morpholines; Piperidines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; S Phase; Signal Transduction; Time Factors; Transfection; Trastuzumab; Tumor Cells, Cultured	2002
Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line. International journal of cancer, 2003, Mar-10, Volume: 104, Issue:1 Topics: Animals; Camphanes; Cannabinol; Cell Communication; Cell Line; Cyclic AMP; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gap Junctions; Liver; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrazoles; Rats; Rats, Inbred F344; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger	2003
Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cellular signalling, 2003, Volume: 15, Issue:9 Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Arachidonic Acids; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Dronabinol; Flavonoids; Gene Expression Regulation; Humans; Liver; Lymphocytes; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphorylation; Piperidines; Polymerase Chain Reaction; Prostate; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Spleen	2003
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. Circulation research, 2003, Dec-12, Volume: 93, Issue:12 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Bosentan; Butadienes; Calcium Channels, T-Type; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Constriction, Pathologic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Gene Expression; Losartan; Male; Membrane Potentials; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nickel; Nitriles; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Endothelin; RNA, Messenger; Signal Transduction; Sulfonamides	2003
HERG K channel conductance promotes H2O2-induced apoptosis in HEK293 cells: cellular mechanisms. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2004, Volume: 14, Issue:3 Topics: Anti-Arrhythmia Agents; Caspase 3; Caspase 9; Caspases; Cell Line; DNA Fragmentation; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; p38 Mitogen-Activated Protein Kinases; Piperidines; Poly(ADP-ribose) Polymerases; Potassium Channels, Voltage-Gated; Pyridines; Signal Transduction	2004
Endothelin-1-dependent leptin induction in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. Biochemical and biophysical research communications, 2005, Nov-04, Volume: 336, Issue:4 Topics: Animals; Aspartic Acid Endopeptidases; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastric Mucosa; Gastritis; Glycopeptides; Helicobacter pylori; Leptin; Lipopolysaccharides; Metalloendopeptidases; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Up-Regulation	2005
Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2005, Volume: 56, Issue:4 Topics: Acetic Acid; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Flavonoids; Glycopeptides; Leptin; Metalloendopeptidases; Mitogen-Activated Protein Kinase Kinases; Mouth Mucosa; Oligopeptides; Oral Ulcer; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Up-Regulation; Wound Healing	2005
Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells. British journal of pharmacology, 2006, Volume: 147, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Benzamides; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Furans; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin-1 Receptor Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors; Umbilical Veins	2006
Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facility. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:5 Topics: Actins; Animals; Aqueous Humor; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Glycerides; Matrix Metalloproteinase 2; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organ Culture Techniques; Perfusion; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Swine; Trabecular Meshwork	2006
HU0622: a small molecule promoting GAP-43 activation and neurotrophic effects. Neuropharmacology, 2006, Volume: 51, Issue:4 Topics: Alkaloids; Animals; Benzodioxoles; Cell Survival; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ganglia, Spinal; GAP-43 Protein; Immunohistochemistry; Luciferases; Nerve Growth Factors; Neurites; Neurons; Piperidines; Polyunsaturated Alkamides; Rats; Transfection; Tubulin	2006
2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling. European journal of pharmacology, 2007, Mar-22, Volume: 559, Issue:2-3 Topics: Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Glycerides; In Vitro Techniques; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pertussis Toxin; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pulmonary Artery; Pyrazoles; Rabbits; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Resorcinols; Rimonabant; Vasodilation; Vasodilator Agents	2007
Endothelin-1 activates MAPKs and modulates cell cycle proteins in OKP cells. Journal of the Formosan Medical Association = Taiwan yi zhi, 2007, Volume: 106, Issue:4 Topics: Animals; Blotting, Western; Cell Cycle Proteins; Cells, Cultured; Endothelin-1; Flavonoids; Kidney; MAP Kinase Signaling System; Oligopeptides; Opossums; Peptides, Cyclic; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-jun; Signal Transduction	2007
Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices. European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3 Topics: Blotting, Western; Butadienes; Cell Line; Cell Proliferation; Cell Survival; Collagen Type I; Dose-Response Relationship, Drug; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Synthesis Inhibitors; Pyridines; Quinazolinones; Time Factors	2007
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. European journal of pharmacology, 2008, Mar-17, Volume: 582, Issue:1-3 Topics: Acetylcholine; Bronchi; Cell Line, Transformed; Chemotaxis, Leukocyte; Epithelial Cells; Flavonoids; Gallamine Triethiodide; Humans; Indoles; Interleukin-8; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscarinic Antagonists; Neutrophils; NF-kappa B; Nitriles; Piperidines; Pirenzepine; Protein Kinase C; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives; Sulfones; Tiotropium Bromide	2008
Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment. European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Donepezil; Flavonoids; Indans; MAP Kinase Signaling System; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Signal Transduction; Up-Regulation	2008
Aqueous humor outflow effects of 2-arachidonylglycerol. Experimental eye research, 2008, Volume: 87, Issue:2 Topics: Animals; Aqueous Humor; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoid Receptor Modulators; Cytoskeleton; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Flavonoids; Glycerides; Monoacylglycerol Lipases; Organ Culture Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Sus scrofa; Trabecular Meshwork	2008
Fibrinogen-induced endothelin-1 production from endothelial cells. American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:4 Topics: Animals; Aspartic Acid Endopeptidases; Butadienes; Cells, Cultured; Coronary Vessels; Endothelial Cells; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Exocytosis; Fibrinogen; Flavonoids; Humans; Intercellular Adhesion Molecule-1; Metalloendopeptidases; Microvessels; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Oligopeptides; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Rats; Receptor, Endothelin B; Sulfonamides; Sulfonylurea Compounds; Vasoconstriction; von Willebrand Factor; Weibel-Palade Bodies	2009
Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5 Topics: Angiotensin II; Animals; Arginine Vasopressin; Butadienes; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Endothelin-1; Endothelins; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Male; MAP Kinase Kinase Kinases; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitriles; Nitroarginine; Nitroprusside; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Vasoconstriction; Vasodilation	2009
DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes. Atherosclerosis, 2010, Volume: 213, Issue:2 Topics: Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Lipopolysaccharides; Macrophages; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Piperidines; Toll-Like Receptor 4; U937 Cells; Uracil	2010
Differential modulation of brainstem phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55,212-2 centrally mediated pressor response in conscious rats. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:1 Topics: Androstadienes; Animals; Benzoxazines; Blood Pressure; Blotting, Western; Brain Stem; Calcium Channel Blockers; Enzyme Inhibitors; Flavonoids; Heart Rate; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Solitary Nucleus; Wortmannin	2012
Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes. The Journal of investigative dermatology, 2012, Volume: 132, Issue:12 Topics: Adenoviridae; alpha-MSH; Animals; Cell Line, Tumor; Diacylglycerol Kinase; Endoplasmic Reticulum; Enzyme Inhibitors; Epidermal Cells; Flavonoids; Gene Expression Regulation, Enzymologic; Hormones; Humans; Indoles; Maleimides; Melanins; Melanocytes; Melanoma, Experimental; Membrane Glycoproteins; Mice; Monophenol Monooxygenase; Oxidoreductases; Piperidines; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Quinazolinones; Skin Neoplasms	2012
Intrathecal endothelin-1 has antinociceptive effects in rat model of postoperative pain. European journal of pharmacology, 2012, Dec-15, Volume: 697, Issue:1-3 Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ganglia, Spinal; Injections, Spinal; Male; Microglia; Oligopeptides; Pain Measurement; Pain Threshold; Pain, Postoperative; Peptides, Cyclic; Phosphorylation; Piperidines; Posterior Horn Cells; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors	2012
Endothelin-1 stimulates the expression of L-type Ca2+ channels in neonatal rat cardiomyocytes via the extracellular signal-regulated kinase 1/2 pathway. The Journal of membrane biology, 2013, Volume: 246, Issue:4 Topics: Animals; Animals, Newborn; Anthracenes; Blotting, Western; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Oligopeptides; Patch-Clamp Techniques; Peptides, Cyclic; Piperidines; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction	2013
Endothelin-1 stimulates proinflammatory cytokine expression in human periodontal ligament cells via mitogen-activated protein kinase pathway. Journal of periodontology, 2014, Volume: 85, Issue:4 Topics: Adult; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Female; Flavonoids; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Periodontal Ligament; Periodontitis; Piperidines; Pyridines; Time Factors; Tumor Necrosis Factor-alpha	2014
Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK. Biochemical pharmacology, 2014, Feb-01, Volume: 87, Issue:3 Topics: Cannabidiol; Cannabinoids; Cell Differentiation; Cell Movement; Cells, Cultured; Cyclohexanes; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Indoles; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Resorcinols	2014
Endothelin-1 stimulates resistin gene expression. Endocrinology, 2014, Volume: 155, Issue:3 Topics: 3T3-L1 Cells; Adipose Tissue; Androstadienes; Animals; Anthracenes; Butadienes; Chromones; Dactinomycin; Endothelin-1; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Morpholines; Nitriles; Oligopeptides; Piperidines; Proto-Oncogene Proteins c-akt; Resistin; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Wortmannin	2014