pd 98059 has been researched along with pd 184352 in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Dai, Y; Dent, P; Grant, S; McInistry, R; Singh, V; Tang, L; Wang, Z; Yu, C | 1 |
| Armstrong, C; Cohen, P; Dixon, J; Leitch, J; Mody, N | 1 |
| Dent, P; Grant, S; Wang, Z; Yu, C | 1 |
| Andreeff, M; Carter, BZ; Estey, E; Estrov, Z; Harris, D; Konopleva, M; Kornblau, SM; Lapillonne, H; Milella, M; Zhao, S | 1 |
| Bonati, A; Costanzo, A; Levrero, M; Lunghi, P | 1 |
| Hauptmann, S; Köbel, M; Pohl, G; Schmitt, WD; Shih, IeM; Wang, TL | 1 |
| Bealmear, B; Benjamins, JA; Dilworth, JT; Kraniak, JM; Mathieu, P; Mattingly, RR; Nowak, JE; Reiners, JJ; Tainsky, MA | 1 |
| Ahmed, A; Ashcroft, M; Chau, NM; Cook, S; Hayat, S; Le Floch, R; Perusinghe, N; Pouyssegur, J; Sutton, KM; Yang, J | 1 |
| Grant, S; Harada, H; Kramer, L; Panaguiton, ZL; Rambal, AA | 1 |
| Gretton, S; Harris, M; Hughes, M | 1 |
| Akpan, A; Burlingame, A; Corless, S; Cramer, R; Naaby-Hansen, S; Nagano, K; Stein, R; Stensballe, A; Timms, JF; Totty, N; Warnasuriya, G; Waterfield, M; Yang, A; Zvelebil, M | 1 |
12 other study(ies) available for pd 98059 and pd 184352
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Butadienes; Caspases; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Jurkat Cells; Leukemia; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Nitriles; Staurosporine; Tumor Cells, Cultured; U937 Cells | 2001 |
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway.
Topics: Amino Acid Sequence; Animals; Benzamides; Butadienes; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HeLa Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Nitriles; Phosphorylation; Sheep | 2001 |
MEK1/2 inhibitors promote Ara-C-induced apoptosis but not loss of Deltapsi(m) in HL-60 cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; AraC Transcription Factor; Bacterial Proteins; Benzamides; Blotting, Western; Butadienes; Carrier Proteins; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Mitogen-Activated Protein Kinase Kinases; Nitriles; Protein Binding; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Repressor Proteins; S100 Proteins; Time Factors; Transcription Factors | 2001 |
Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia.
Topics: Apoptosis; Benzamides; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytarabine; Enzyme Inhibitors; Flavonoids; Humans; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Proteins; X-Linked Inhibitor of Apoptosis Protein | 2001 |
Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Benzamides; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Genes, Tumor Suppressor; Humans; In Vitro Techniques; K562 Cells; Leukemia, Erythroblastic, Acute; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nuclear Proteins; Oxides; Proteins; Tumor Protein p73; Tumor Suppressor Proteins | 2004 |
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor.
Topics: Benzamides; Case-Control Studies; Cell Movement; Cells, Cultured; Enzyme Activation; Female; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Pregnancy; Protein Kinase Inhibitors; Trophoblastic Tumor, Placental Site; Trophoblasts; Uterine Neoplasms | 2005 |
The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.
Topics: Apoptosis; Benzamides; Blotting, Western; Butadienes; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, p53; Genes, ras; Humans; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinase Kinases; Neurilemmoma; Neurofibromatosis 1; Nitriles; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2006 |
Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.
Topics: Benzamides; Blotting, Western; Butadienes; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Drug; Flavonoids; Gene Expression; Humans; Hypoxia-Inducible Factor 1; Insulin-Like Growth Factor I; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitriles; Phosphorylation; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection | 2007 |
MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Benzamides; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell Survival; Dexamethasone; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Immunoprecipitation; MAP Kinase Kinase 1; Membrane Proteins; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Conformation; Proto-Oncogene Proteins; Subcellular Fractions | 2009 |
Hepatitis C virus RNA replication is regulated by Ras-Erk signalling.
Topics: Benzamides; Butadienes; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hepacivirus; MAP Kinase Kinase 1; Nitriles; ras GTPase-Activating Proteins; RNA, Viral; Signal Transduction; Virus Replication | 2010 |
Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Benzamides; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Flavonoids; Insulin-Like Growth Factor I; Isotope Labeling; Mice; Morpholines; Nucleosome Assembly Protein 1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Proteome; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Signal Transduction | 2012 |