Compounds > pd 98059

pd 98059 and n-formylmethionine leucyl-phenylalanine

pd 98059 has been researched along with n-formylmethionine leucyl-phenylalanine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (31.58)18.2507
2000's24 (63.16)29.6817
2010's2 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Avdi, NJ; Johnson, GL; Russel, M; Winston, BW; Worthen, GS; Young, SK1
Kuroki, M; O'Flaherty, JT1
Cario, AC; Loo, KC; Walters, JD; Zhang, F1
Boxer, LA; Mansfield, PJ; Shayman, JA; Suchard, SJ1
Coffer, PJ; Geijsen, N; Koenderman, L; Lammers, JW; M'rabet, L; Maikoe, T; Raaijmakers, JA; Schweizer, RC1
Car, BD; Meunier, PC; Schnyder, B1
Boulay, F; Christophe, T; Milcent, MD; Rabiet, MJ; Tardif, M1
Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH1
Ferrante, A; Hii, CS; Moghaddami, N; Murray, AW; Stacey, K1
Hubbard, WC; MacGlashan, DW; Miura, K; Schroeder, JT1
Ezekiel, UR; Heuertz, RM; Tricomi, SM; Webster, RO1
Djerdjouri, B; Giroud, JP; Lenoir, M; Périanin, A1
Bates, ME; Bertics, PJ; Green, VL1
Dewas, C; El-Benna, J; Fay, M; Gougerot-Pocidalo, MA1
Ammon, HP; Bertsche, T; Boden, SE; Safayhi, H1
Linch, DC; Mollapour, E; Roberts, PJ1
Byrnes, HD; Fine, JS; Hipkin, RW; Zavodny, PJ1
Buridi, A; Coxon, PY; Kettritz, R; Klein, JB; Manning, T; McLeish, KR; Rane, MJ1
Irita, K; Kansha, M; Nagata, T; Takahashi, S1
Brunelleschi, S; Colangelo, D; Gaudino, G; Lavagno, L; Penengo, L; Santoro, C; Viano, I1
Dackiw, AP; Marshall, JC; McGilvray, ID; Rotstein, OD; Tsai, V1
Gibbs, BF; Grabbe, J; Plath, KE; Wolff, HH1
Calzetti, F; Cassatella, MA; Crepaldi, L; Pinardi, C; Scapini, P1
Chmiel, KJ; Choi, H; Serikov, VB; Widdicombe, JH; Wu, R1
Hato, F; Ishii, M; Kamata, N; Kato, T; Kitagawa, S; Kobayashi, H; Kutsuna, H; Mizuno, K; Suzuki, K1
Butt, W; Chen, Q; Coxon, PY; McLeish, KR; Powell, DW; Rane, MJ; Singh, S; Uriarte, S1
Katada, T; Kontani, K; Kurosu, H; Momose, H; Nishina, H; Tsujimoto, N; Tsujita, K1
Barja-Fidalgo, C; Coelho, AL; De Freitas, MS; Mariano-Oliveira, A; Selistre-de-Araújo, HS; Terruggi, CH1
Ammendola, R; Cimino, F; De Felice, C; Esposito, F; Russo, L; Russo, T1
Allen, JM; Bertrand, C; Jacob, C; Lagente, V; Szilagyi, C1
Fujita, T; Kurihara, H; Van Dyke, TE; Zawawi, KH1
Kuan, YH; Lin, CN; Lin, RH; Tsao, LT; Wang, JP1
Bifulco, K; Campiglia, P; Carriero, MV; Franco, P; Gargiulo, L; Grieco, P; Longanesi-Cattani, I; Peluso, G; Raiola, R; Stoppelli, MP1
During, RL; Hao, B; Koenig, JM; Li, W; Quinn, CP; Southwick, FS; Stephens, DS1
Ayilavarapu, S; Batista, EL; Hasturk, H; Iwata, T; Kantarci, A; Liu, H; Ohira, T; Omori, K; Uchida, Y; Van Dyke, TE; Yagi, M1
Cui, Y; Hou, X; Le, Y; Ruan, L; Wang, JM; Wang, O; Zhu, J1
Brooks, AC; Cunningham, FM; Pickles, KJ; Rickards, KJ1
Li, Y; Liu, X; Ma, B; Malik, AB; Minshall, RD; Sun, B; Tang, H; Wang, G; Xu, J; Yang, T; Ye, RD; Zhao, Y1

Other Studies

38 other study(ies) available for pd 98059 and n-formylmethionine leucyl-phenylalanine

ArticleYear
Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation.
    The Journal of biological chemistry, 1996, Dec-27, Volume: 271, Issue:52

    Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Virulence Factors, Bordetella; Wortmannin

1996
Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors.
    Biochemical and biophysical research communications, 1997, Mar-17, Volume: 232, Issue:2

    Topics: Chemotactic Factors; Complement C5a; Enzyme Activation; Flavonoids; Humans; Interleukin-8; Leukotriene B4; Mitogen-Activated Protein Kinase Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase Inhibitors; Protein Kinases

1997
Regulation of ciprofloxacin uptake in human promyelocytic leukemia cells and polymorphonuclear leukocytes.
    Journal of leukocyte biology, 1997, Volume: 61, Issue:5

    Topics: Anti-Infective Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ciprofloxacin; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Protein Kinase C

1997
Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.
    Journal of immunology (Baltimore, Md. : 1950), 1997, May-15, Volume: 158, Issue:10

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoglobulin G; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Fc

1997
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.
    The Biochemical journal, 1998, Jan-01, Volume: 329 ( Pt 1)

    Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Cytokines; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Protein Kinases; Respiratory Burst; Signal Transduction; Wortmannin; Zymosan

1998
Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.
    The Biochemical journal, 1998, Apr-15, Volume: 331 ( Pt 2)

    Topics: Androstadienes; Blood Bactericidal Activity; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Respiratory Burst; Staphylococcus aureus; Thiazoles; Wortmannin

1998
Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Dec-15, Volume: 161, Issue:12

    Topics: Androstadienes; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; HL-60 Cells; Humans; Isoenzymes; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neoplasm Proteins; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella; Wortmannin

1998
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Feb-15, Volume: 162, Issue:4

    Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine

1999
Role of the extracellular signal-regulated protein kinase cascade in human neutrophil killing of Staphylococcus aureus and Candida albicans and in migration.
    Infection and immunity, 1999, Volume: 67, Issue:3

    Topics: Blood Bactericidal Activity; Calcium-Calmodulin-Dependent Protein Kinases; Candida albicans; Cell Movement; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Staphylococcus aureus

1999
Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Apr-01, Volume: 162, Issue:7

    Topics: Antibodies, Anti-Idiotypic; Basophils; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Flavonoids; Histamine Release; Humans; Immunoglobulin E; Interleukin-4; Leukotriene C4; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation

1999
C-reactive protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement.
    The Journal of biological chemistry, 1999, Jun-18, Volume: 274, Issue:25

    Topics: C-Reactive Protein; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Chemotaxis; Flavonoids; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Signal Transduction

1999
Contribution of mitogen-activated protein kinase to stimulation of phospholipase D by the chemotactic peptide fMet-Leu-Phe in human neutrophils.
    Biochemical and biophysical research communications, 1999, Oct-22, Volume: 264, Issue:2

    Topics: Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycerophospholipids; Humans; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Respiratory Burst; Superoxides

1999
ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis.
    The Journal of biological chemistry, 2000, Apr-14, Volume: 275, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Butadienes; Chemokine CCL5; Dose-Response Relationship, Drug; Eosinophils; Flavonoids; GRB2 Adaptor Protein; Humans; Interleukin-5; Interleukin-8; Leukotriene C4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Nitriles; Phosphorylation; Proteins

2000
The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Nov-01, Volume: 165, Issue:9

    Topics: Butadienes; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Nitriles; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst

2000
MEK-1/2 inhibition prevents 5-lipoxygenase translocation in N-formylpeptide-challenged human neutrophils.
    The international journal of biochemistry & cell biology, 2000, Volume: 32, Issue:10

    Topics: Arachidonate 5-Lipoxygenase; Butadienes; Calcimycin; Calcium; Cell-Free System; Enzyme Activation; Flavonoids; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Protein-Tyrosine Kinases; Pyridines

2000
Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosol
    Blood, 2001, Apr-15, Volume: 97, Issue:8

    Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Complement C5a; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Group VI Phospholipases A2; Humans; Imidazoles; Ionophores; Isoenzymes; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Organophosphonates; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha

2001
Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.
    Inflammation, 2001, Volume: 25, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Colforsin; Flavonoids; Humans; In Vitro Techniques; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin

2001
Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.
    Cellular signalling, 2001, Volume: 13, Issue:5

    Topics: Androstadienes; Apoptosis; Chemotaxis, Leukocyte; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leukotriene B4; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Virulence Factors, Bordetella; Wortmannin

2001
Propofol inhibits FMLP-stimulated phosphorylation of p42 mitogen-activated protein kinase and chemotaxis in human neutrophils.
    British journal of anaesthesia, 2001, Volume: 86, Issue:6

    Topics: Anesthetics, Intravenous; Cells, Cultured; Chemotaxis, Leukocyte; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinase 1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Phosphorylation; Propofol; Signal Transduction; Statistics, Nonparametric; Stimulation, Chemical

2001
Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.
    British journal of pharmacology, 2001, Volume: 134, Issue:6

    Topics: Adult; Androstadienes; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Growth Substances; Hepatocyte Growth Factor; Humans; Imidazoles; Insecta; Macrophages; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Proto-Oncogene Proteins; Pyridines; Receptors, Drug; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin

2001
Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases.
    Shock (Augusta, Ga.), 2002, Volume: 18, Issue:1

    Topics: Antibodies; CD18 Antigens; Cell Adhesion; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Imidazoles; Inflammation; Integrin beta1; Mitogen-Activated Protein Kinases; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Pyridines; Thromboplastin; Tumor Necrosis Factor-alpha

2002
Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization.
    Journal of leukocyte biology, 2002, Volume: 72, Issue:2

    Topics: Albuterol; Basophils; Calcimycin; Calcium Channel Blockers; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Histamine Release; Humans; Imidazoles; Immunoglobulin E; Interleukin-13; Interleukin-4; Interleukins; Leukotriene C4; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Salmeterol Xinafoate; Second Messenger Systems; Theophylline

2002
CCL20/macrophage inflammatory protein-3alpha production in LPS-stimulated neutrophils is enhanced by the chemoattractant formyl-methionyl-leucyl-phenylalanine and IFN-gamma through independent mechanisms.
    European journal of immunology, 2002, Volume: 32, Issue:12

    Topics: Chemokine CCL20; Chemokines, CC; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyridines; Receptors, CCR6; Receptors, Chemokine; Recombinant Proteins; RNA Stability; RNA, Messenger; Signal Transduction; Up-Regulation

2002
Activation of extracellular regulated kinases is required for the increase in airway epithelial permeability during leukocyte transmigration.
    American journal of respiratory cell and molecular biology, 2004, Volume: 30, Issue:3

    Topics: Animals; Cattle; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Leukocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophils; Permeability; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; Trachea

2004
Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF, and G-CSF: the role of MAP kinases.
    American journal of physiology. Cell physiology, 2004, Volume: 286, Issue:1

    Topics: Actin Depolymerizing Factors; Actins; Adult; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Microfilament Proteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polymers; Pyridines; Recombinant Proteins; Tumor Necrosis Factor-alpha

2004
MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.
    Cellular signalling, 2003, Volume: 15, Issue:11

    Topics: Chemotaxis, Leukocyte; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Flavonoids; Humans; Imidazoles; Interleukin-8; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst; Signal Transduction; Superoxides

2003
Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fc gamma and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Oct-15, Volume: 171, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Cell Differentiation; Cell Line; Cross-Linking Reagents; Drug Synergism; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Formyl Peptide; Receptors, IgG; Serine; Superoxides; Threonine

2003
Alternagin-C, a nonRGD-disintegrin, induces neutrophil migration via integrin signaling.
    European journal of biochemistry, 2003, Volume: 270, Issue:24

    Topics: Actins; Active Transport, Cell Nucleus; Amino Acid Motifs; Animals; Bothrops; Cell Movement; Cell Nucleus; Chemotaxis; Cytoskeleton; Disintegrins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Humans; Immunoblotting; Immunohistochemistry; Integrins; Mitogen-Activated Protein Kinase 1; N-Formylmethionine Leucyl-Phenylalanine; Neoplasm Metastasis; Neovascularization, Pathologic; Neutrophils; Peptides; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Precipitin Tests; Protein Structure, Tertiary; Signal Transduction; Snake Venoms; Time Factors

2003
Low-affinity receptor-mediated induction of superoxide by N-formyl-methionyl-leucyl-phenylalanine and WKYMVm in IMR90 human fibroblasts.
    Free radical biology & medicine, 2004, Jan-15, Volume: 36, Issue:2

    Topics: Cell Line; Enzyme Activation; Fibroblasts; Flavonoids; Growth Substances; Humans; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Oligopeptides; Pertussis Toxin; Phosphoproteins; Phosphorylation; Protein Transport; Receptors, Formyl Peptide; Receptors, Lipoxin; Superoxides

2004
Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.
    British journal of pharmacology, 2004, Volume: 143, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bronchoalveolar Lavage Fluid; Bucladesine; CREB-Binding Protein; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Rolipram; Superoxides; Trans-Activators

2004
CD38 cleavage in fMLP- and IL-8-induced chemotaxis is dependent on p38 MAP kinase but independent of p44/42 MAP kinase.
    Cellular signalling, 2005, Volume: 17, Issue:2

    Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Chemotaxis; Cyclic ADP-Ribose; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-8; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphorylation; Pyridines; Receptors, Formyl Peptide; Receptors, Lipoxin; Tosyl Compounds

2005
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.
    British journal of pharmacology, 2005, Volume: 145, Issue:4

    Topics: Animals; Butadienes; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Immunoblotting; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases

2005
Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide.
    The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26

    Topics: Actins; Alanine; Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Cell Movement; Chemotaxis; Chromones; Cytoskeleton; Dose-Response Relationship, Drug; Flavonoids; Humans; Immunoprecipitation; Integrin alphaV; Integrin alphaVbeta3; Integrin beta4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Peptides; Phosphorylation; Protein Binding; Protein Kinase C; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Signal Transduction; Temperature; Time Factors; Vitronectin; Wortmannin

2005
Anthrax lethal toxin paralyzes neutrophil actin-based motility.
    The Journal of infectious diseases, 2005, Sep-01, Volume: 192, Issue:5

    Topics: Actins; Anthrax; Antigens, Bacterial; Apoptosis; Bacillus anthracis; Bacterial Toxins; Chemotaxis; Cytoskeleton; Flavonoids; Flow Cytometry; Humans; MAP Kinase Kinase 1; Microscopy, Phase-Contrast; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase Inhibitors

2005
Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase.
    Journal of leukocyte biology, 2008, Volume: 84, Issue:1

    Topics: Adult; Cell Membrane; Diabetes Mellitus; Female; Flavonoids; HL-60 Cells; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Respiratory Burst; Superoxides

2008
The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR.
    International immunopharmacology, 2009, Volume: 9, Issue:9

    Topics: Animals; Antioxidants; Calcium-Calmodulin-Dependent Protein Kinases; Camellia sinensis; Catechin; Cell Line, Tumor; Cell Movement; Flavonoids; Humans; Inflammation; Injections, Intraperitoneal; Leukemia, Basophilic, Acute; Mice; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Rats; Receptors, Formyl Peptide; Signal Transduction; Transfection; Transgenes

2009
Expression of annexin-1 in equine leucocytes and the effects of the N-terminal annexin-1 peptide, Ac2-26, on equine neutrophil superoxide production.
    Veterinary immunology and immunopathology, 2010, Jun-15, Volume: 135, Issue:3-4

    Topics: Amino Acid Sequence; Animals; Annexin A1; Flavonoids; Horses; Humans; In Vitro Techniques; Leukocytes; MAP Kinase Signaling System; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Peptides; Rabbits; Superoxides

2010
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.
    Nature immunology, 2012, Mar-25, Volume: 13, Issue:5

    Topics: Animals; Chemotaxis, Leukocyte; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G-Protein-Coupled Receptor Kinase 2; HEK293 Cells; HL-60 Cells; Humans; Imidazoles; Mice; Mice, Knockout; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Formyl Peptide; Signal Transduction

2012