pd 98059 and indomethacin

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Adenosine Triphosphate; Blood Platelets; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Collagen; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indomethacin; Ionophores; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Platelet Aggregation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Serotonin; Serotonin Receptor Agonists; Thrombin

Topics: Cell Division; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Indomethacin; Isoenzymes; MAP Kinase Kinase 1; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction

Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cytosol; Dinoprostone; Down-Regulation; Drug Interactions; Flavonoids; Guinea Pigs; Indoles; Indomethacin; Maleimides; Muscle, Smooth; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Trachea

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Aorta; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Cytochrome P-450 Enzyme System; DNA; Enzyme Inhibitors; Fatty Acids, Unsaturated; Flavanones; Flavonoids; Indomethacin; Lipoxygenase; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Signal Transduction; Thymidine

Topics: Acetylcholine; Animals; Arachidonic Acid; Brain Chemistry; Chick Embryo; Cycloheximide; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Indomethacin; Ion Channel Gating; Isoquinolines; Maleimides; Masoprocol; Membrane Potentials; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Receptors, Nicotinic; Sulfonamides; Torpedo; Xenopus

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Cycle; Cell Division; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Humans; Indomethacin; Kinetics; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; U937 Cells

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Calmodulin-Dependent Protein Kinases; Dentate Gyrus; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Flavonoids; Imidazoles; In Vitro Techniques; Indomethacin; Interleukin-1; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Perforant Pathway; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Flavonoids; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Neoplasms; Neovascularization, Pathologic; Nitrobenzenes; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides; Wound Healing

Topics: Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Flavonoids; Hydrazines; Indomethacin; Male; Methoxamine; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Potassium Chloride; Rats; Rats, Wistar; Reactive Oxygen Species; Vasoconstriction

Topics: Animals; Blood Platelets; Carbazoles; Cattle; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Humans; Imidazoles; Indoles; Indomethacin; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Processing, Post-Translational; Pyridines; Serotonin; Serum Albumin, Bovine; Thrombin; Thrombopoietin; Thromboxane A2

Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; Hindlimb; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Morphine; Nerve Growth Factor; Time Factors

Topics: Adenine; Androstadienes; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Hydrocortisone; Indomethacin; Naphthalenes; Nifedipine; Oligopeptides; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase C; Pyrazoles; Pyrrolidinones; Receptors, Endothelin; Signal Transduction; Type C Phospholipases; Tyrphostins; Wortmannin; Zona Fasciculata; Zona Reticularis

Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcium Signaling; Cells, Cultured; Cholecystokinin; Enzyme Inhibitors; Flavonoids; Imidazoles; Indomethacin; Kinetics; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Phosphorylation; Pyridines

Topics: Acetylcysteine; Arsenites; Blotting, Northern; Blotting, Western; Colorectal Neoplasms; Curcumin; Cyclooxygenase Inhibitors; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; HSP70 Heat-Shock Proteins; Humans; Indomethacin; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Time Factors; Transcription, Genetic; Tumor Cells, Cultured

Topics: Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Estrenes; Flavonoids; Humans; In Vitro Techniques; Indomethacin; Kinetics; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Pyrrolidinones; Serotonin; Thromboxane A2; Verapamil

Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Nucleus; DNA; DNA Mutational Analysis; Flavonoids; Gene Deletion; Humans; Immunoblotting; Indomethacin; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protease Inhibitors; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transcription, Genetic; Tumor Cells, Cultured

Topics: Alkyl and Aryl Transferases; Animals; Cell Line; Cloprostenol; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprost; Diphosphonates; Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Flavonoids; Gene Expression; Indoles; Indomethacin; Intercellular Signaling Peptides and Proteins; Lymphokines; Maleimides; Mice; Osteoblasts; Prostaglandins F, Synthetic; Protein Kinase C; RNA, Messenger; Sodium Fluoride; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Alkaline Phosphatase; Butadienes; Cell Differentiation; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; Humans; Indomethacin; Integrin beta1; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Osteoblasts; Pertussis Toxin; Phosphorylation; Prostaglandins; Protein Serine-Threonine Kinases; Signal Transduction; Stress, Mechanical; Thymidine; Tritium

Topics: Adenosine; Animals; Arterioles; Cyclooxygenase Inhibitors; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Vasomotor System

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Arachidonic Acid; Buspirone; Calcimycin; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Flavonoids; Humans; Indoles; Indomethacin; Maleimides; Pertussis Toxin; Phorbol Esters; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Time Factors; Tryptamines

Topics: Actins; Angiotensin II; Animals; Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; DNA, Antisense; Enzyme Inhibitors; Flavonoids; Gene Expression; Glomerular Mesangium; Glucose; Hypoglycemic Agents; Indomethacin; Ligands; Pioglitazone; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Transcription Factors; Vasoconstrictor Agents

Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dinoprostone; Diuresis; Enzyme Inhibitors; Flavonoids; Indomethacin; Interleukin-1; LLC-PK1 Cells; Mitogen-Activated Protein Kinases; Natriuresis; NF-kappa B; Proline; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Swine; Thiocarbamates

Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Antagonists; Adult; Arachidonic Acid; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Drug Synergism; Epinephrine; Female; Flavonoids; Humans; Indomethacin; Male; Platelet Aggregation; Receptors, G-Protein-Coupled; Signal Transduction; Type C Phospholipases; Verapamil; Yohimbine

Topics: Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Immunoassay; Immunoblotting; Immunohistochemistry; Indomethacin; Lipoproteins, LDL; Membrane Proteins; NF-kappa B; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane A2; Time Factors; Umbilical Veins

Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Guanidines; Humans; Immunohistochemistry; Indomethacin; Mast Cells; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrobenzenes; Phosphorylation; Prostaglandins; Receptor, PAR-2; Serine Endopeptidases; Sulfonamides; Tryptases

Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Flavonoids; Glioma; Humans; Indomethacin; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Protein Kinase Inhibitors; Pyrimidines; Rats; src-Family Kinases; Sulfonamides; Time Factors

Topics: Animals; Carrier Proteins; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genistein; Glycoproteins; Indomethacin; Membrane Glycoproteins; Mice; Osteoblasts; Osteoprotegerin; Protein Kinase Inhibitors; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tensile Strength

Topics: Acetaminophen; Animals; Anthracenes; Cell Line; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Indomethacin; Interleukin-1beta; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mice; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction; Theophylline; Tumor Necrosis Factor-alpha

Topics: Animals; Apoptosis; Benzophenanthridines; Cell Movement; Cell Proliferation; Culture Media, Conditioned; DNA; Endothelial Cells; Estradiol; Female; Flavonoids; Indomethacin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Progesterone; Rats; Rats, Wistar; Time Factors

Topics: Apoptosis; Autocrine Communication; Caspase 3; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Flavonoids; HL-60 Cells; Humans; Indomethacin; Isoquinolines; Lamin Type B; Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfonamides; Vitamin K 3