Compounds > pd 98059

pd 98059 and herbimycin

pd 98059 has been researched along with herbimycin in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (29.55)18.2507
2000's27 (61.36)29.6817
2010's4 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boudreau, M; Hwang, D; Jang, BC; Yu, G1
Bhardwaj, D; Eyster, KM; Mijovic, JE; Olson, DM; Zakar, T1
Linder, S; Ljungdahl, S; Shoshan, MC; Swedenborg, J; Zhou, JN1
Barton, C; Biggs, T; Mann, D1
Barnes, PJ; Giembycz, MA; Haddad, EB; Hellewell, PG; Lindsay, MA; Rousell, J; Teixeira, MM1
Funa, K; Ishisaki, A; Matsumoto, T; Mori, S; Saito, Y; Takemoto, M; Tamura, K; Yokote, K1
Minami, K; Mue, S; Ohuchi, K; Xiao, YQ1
Baccarini, M; Kovarik, P; Procyk, KJ; von Gabain, A1
Haneda, M; Ishida, T; Kikkawa, R; Koya, D; Maeda, S1
Daaka, Y; McAllen, K; Shahabi, NA; Sharp, BM1
Ahn, BK; Chung, BS; Do, IR; Jhun, BH; Kang, CD; Kim, KW; Kim, SH; Yoo, MA1
Calvo, J; Cid, MC; Esparza, J; Juan, M; Urbano-Márquez, A; Vilardell, C; Vives, J; Yagüe, J1
Henrion, D; Lehoux, S; Lévy, BI; Loufrani, L; Tedgui, A1
Strayer, DS; White, MK1
Chung, BS; Hwang, BW; Kang, CD; Kim, CM; Kim, DW; Kim, KW; Kim, SH; Yoo, SD1
Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Luo, SF; Wang, CC; Yang, CM1
Hobson, SA; Lee, F; McNeil, SE; Rodland, KD1
Dreja, K; Hellstrand, P; Malmqvist, U; Nordström, I; Zeidan, A1
Boland, R; Buitrago, C; De Boland, AR; Morelli, S; Vazquez, G1
Kitamura, M; Konta, T; Lucio-Cazana, J; Moreno-Manzano, V; Nakayama, K1
Bertics, PJ; Chun, TY; Gorski, J; Kim, YN; Watters, JJ1
Dobrian, AD; Prewitt, RL; Schriver, SD; Wesselman, JP1
Barrett, JC; Cykert, DM; Dunn, SE; Oh, JS; Torres, JV1
Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Pan, SL; Wang, CC; Yang, CM1
Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Shyr, MH; Wang, CC; Yang, CM1
Ishihara, K; Mue, S; Ohuchi, K; Satoh, I1
Chakraborty, C; Gleeson, LM; Lala, PK; McKinnon, T1
Claes, P; Grobben, B; Roymans, D; Slegers, H1
Byers, DM; Cook, HW; Ridgway, ND; Sunohara, JR1
Howard, LL; Weiss, RH1
Aoki, T; Hakeda, Y; Hayakawa, H; Hayakawa, T; Kobayashi, Y; Kumegawa, M; Noguchi, T; Sobue, T; Yamashita, K1
Li Calzi, S; Li, DP; Periyasamy, S; Sánchez, ER1
Bompadre, MB; Coso, OA; Fernández, GC; Gómez, S; Isturiz, MA; Palermo, MS; Rosa, FA; Rubel, C1
Hayashi, K; Kadomatsu, K; Muramatsu, T1
Fan, YP; Puri, RN; Rattan, S1
Chang, YC; Hsieh, YS; Huang, FM; Liu, CM; Yang, LC; Yang, SF1
Giebisch, G; Hebert, SC; Jin, Y; Li, D; Lin, DH; Sun, P; Wang, WH; Wang, Z1
Huang, H; Huang, WH; Liu, J; Luo, GX; Peng, DZ; Zheng, JS; Zhou, X1
Daoud, G; Lafond, J; Le bellego, F1
Harigaya, K; Harima, A; Kitagawa, M; Morimoto, C; Nakaseko, C; Saito, Y; Yokota, A1
Chen, S; Xing, F; Zhang, X1
Chang, YC; Huang, FM; Lee, SS; Tsai, CH1
Choi, S; Jiao, HY; Jun, JY; Kim, MW; Kim, SW; Lee, MJ; Na, J; Park, CG; Park, IK; Shin, DH; So, I1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1

Other Studies

44 other study(ies) available for pd 98059 and herbimycin

ArticleYear
Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages.
    Biochemical pharmacology, 1997, Jul-01, Volume: 54, Issue:1

    Topics: Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; I-kappa B Proteins; Imidazoles; Lactams, Macrocyclic; Lactones; Lipopolysaccharides; Macrolides; Macrophages; Mice; Mitogens; NF-kappa B; NF-KappaB Inhibitor alpha; Prostaglandin-Endoperoxide Synthases; Pyridines; Quinones; Rifabutin; RNA, Messenger; Signal Transduction

1997
Regulation of prostaglandin H2 synthase-2 expression in primary human amnion cells by tyrosine kinase dependent mechanisms.
    Biochimica et biophysica acta, 1998, Mar-06, Volume: 1391, Issue:1

    Topics: Amnion; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Humans; In Situ Hybridization; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate

1998
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
    Molecular carcinogenesis, 1998, Volume: 21, Issue:4

    Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactinomycin; DNA, Complementary; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Hydroquinones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Okadaic Acid; Phenols; Proto-Oncogene Proteins c-raf; Quinones; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured

1998
A proposed mechanism for the induction of activator protein 1 (AP-1) binding by HIV-1 negative factor(Nef) in the macrophage cell line RAW267.4 cells.
    Biochemical Society transactions, 1998, Volume: 26, Issue:3

    Topics: Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Gene Products, nef; HIV-1; Lactams, Macrocyclic; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; nef Gene Products, Human Immunodeficiency Virus; Quinones; Rifabutin; Transcription Factor AP-1

1998
Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation.
    Journal of leukocyte biology, 1998, Volume: 64, Issue:4

    Topics: Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Flavonoids; Guinea Pigs; JNK Mitogen-Activated Protein Kinases; Kinetics; Lactams, Macrocyclic; Leukotriene B4; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peritoneal Cavity; Phenols; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinones; Rifabutin

1998
Fibronectin stimulates transcription of the platelet-derived growth factor beta-receptor in cultured rat aortic smooth muscle cells.
    Biochemical and biophysical research communications, 1998, Oct-29, Volume: 251, Issue:3

    Topics: Animals; Aorta; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fibronectins; Flavonoids; Genes, Reporter; Integrins; Lactams, Macrocyclic; Luciferases; Muscle, Smooth, Vascular; Promoter Regions, Genetic; Protein Kinase Inhibitors; Quinones; Rats; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Rifabutin; Signal Transduction; Transcription, Genetic

1998
Pharmacological analysis of protein kinases responsible for chemotaxis of rat peritoneal neutrophils.
    European journal of pharmacology, 1998, Nov-06, Volume: 360, Issue:2-3

    Topics: Animals; Ascitic Fluid; Benzoquinones; Chemokine CXCL2; Chemokines, CXC; Chemotactic Factors; Chemotaxis; Enzyme Inhibitors; Flavonoids; Growth Substances; Intercellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Monokines; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin

1998
Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates.
    Infection and immunity, 1999, Volume: 67, Issue:3

    Topics: Androstadienes; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Flavonoids; Lactams, Macrocyclic; Lipopolysaccharides; Macrophages; Phagocytosis; Phosphatidylinositol 3-Kinases; Phospholipase D; Protein Kinase C; Protein Serine-Threonine Kinases; Quinones; Rifabutin; Salmonella typhimurium; Signal Transduction; Wortmannin

1999
Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase.
    Diabetes, 1999, Volume: 48, Issue:3

    Topics: Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Gene Expression Regulation; Glomerular Mesangium; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lactams, Macrocyclic; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Naphthalenes; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; RNA, Messenger; Stress, Mechanical; Time Factors; Transcription Factor AP-1; Transcription, Genetic

1999
Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner.
    Journal of neuroimmunology, 1999, Feb-01, Volume: 94, Issue:1-2

    Topics: Adjuvants, Immunologic; Animals; Benzoquinones; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; GTPase-Activating Proteins; Humans; Jurkat Cells; Lactams, Macrocyclic; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; Pertussis Toxin; Phosphorylation; Proteins; Proto-Oncogene Proteins c-fos; Quinones; ras GTPase-Activating Proteins; ras Proteins; Receptors, Opioid, delta; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1999
Role of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells.
    Experimental & molecular medicine, 1999, Jun-30, Volume: 31, Issue:2

    Topics: Androstadienes; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Flavonoids; Humans; K562 Cells; Lactams, Macrocyclic; Leukemia, Myeloid; Oligonucleotides, Antisense; Quinones; ras Proteins; Rifabutin; Wortmannin

1999
Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways.
    Blood, 1999, Oct-15, Volume: 94, Issue:8

    Topics: Androstadienes; Antibodies, Monoclonal; Benzoquinones; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, ras; GTP-Binding Proteins; Humans; Imidazoles; Integrins; Jurkat Cells; Lactams, Macrocyclic; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neoplasm Proteins; Peptide Fragments; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras); Pyridines; Quinones; Rifabutin; src-Family Kinases; T-Lymphocytes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin

1999
Stretch induces mitogen-activated protein kinase activation and myogenic tone through 2 distinct pathways.
    Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:12

    Topics: Animals; Benzoquinones; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Genistein; Indoles; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Tonus; Protein Kinase C; Quinones; Rabbits; Rifabutin; Temperature; Vasoconstriction; Veins

1999
Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells.
    Experimental cell research, 2000, Feb-25, Volume: 255, Issue:1

    Topics: Animals; Benzoquinones; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genistein; Insulin Receptor Substrate Proteins; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinones; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Rifabutin; Tyrosine

2000
The inhibition of ERK/MAPK not the activation of JNK/SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells.
    Leukemia research, 2000, Volume: 24, Issue:6

    Topics: Apoptosis; Benzoquinones; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; K562 Cells; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Quinones; Rifabutin; Tumor Cells, Cultured

2000
Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells.
    British journal of pharmacology, 2000, Volume: 130, Issue:4

    Topics: Animals; Benzoquinones; Bridged-Ring Compounds; Calcium; Cell Division; Chelating Agents; DNA; Dogs; Egtazic Acid; Enzyme Activation; Estrenes; Female; Flavonoids; Interleukin-1; Isoenzymes; Lactams, Macrocyclic; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; Norbornanes; Pertussis Toxin; Phosphorylation; Protein Kinase C; Pyrrolidinones; Quinones; Rifabutin; Thiocarbamates; Thiones; Thymidine; Trachea; Tritium; Tumor Necrosis Factor-alpha; Type C Phospholipases; Virulence Factors, Bordetella

2000
Signal transduction mechanisms linking increased extracellular calcium to proliferation in ovarian surface epithelial cells.
    Experimental cell research, 2000, Jul-10, Volume: 258, Issue:1

    Topics: Amino Acid Substitution; Animals; Benzoquinones; Calcium; Calcium Signaling; Cell Division; Enzyme Inhibitors; Epithelial Cells; Extracellular Space; Female; Flavonoids; Kidney; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Ovary; Quinones; Rats; Receptors, Calcium-Sensing; Receptors, Cell Surface; Recombinant Proteins; Rifabutin; src-Family Kinases; Transfection

2000
Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein.
    Circulation research, 2000, Aug-04, Volume: 87, Issue:3

    Topics: Animals; Benzoquinones; Cattle; Culture Media; Culture Media, Serum-Free; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Female; Fetal Blood; Flavonoids; Hyperplasia; Hypertrophy; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle Development; Muscle Proteins; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Organ Culture Techniques; Organ Size; Phenotype; Portal Vein; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Signal Transduction; Stress, Mechanical

2000
Involvement of tyrosine kinase activity in 1alpha,25(OH)2-vitamin D3 signal transduction in skeletal muscle cells.
    The Journal of biological chemistry, 2000, Nov-17, Volume: 275, Issue:46

    Topics: Animals; Benzoquinones; Calcitriol; Calcium; Calcium Signaling; Cells, Cultured; Chick Embryo; DNA; Enzyme Activation; Flavonoids; Genistein; Isoenzymes; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Quinones; Rifabutin; Signal Transduction; Type C Phospholipases; Vanadates

2000
Enhancement of TNF-alpha-induced apoptosis by immobilized arginine-glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism.
    Biochemical and biophysical research communications, 2000, Oct-22, Volume: 277, Issue:2

    Topics: Animals; Apoptosis; Benzoquinones; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Genistein; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinases; Mutation; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rats; Rifabutin; Time Factors; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha

2000
Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells.
    Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:11

    Topics: Animals; Benzoquinones; Butadienes; Cells, Cultured; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrogens; Female; Flavonoids; Gene Expression Regulation; Lactams, Macrocyclic; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pituitary Gland; Prolactin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Pyrazoles; Pyrimidines; Quinones; Rats; Rats, Inbred F344; Rifabutin; RNA, Messenger; Signal Transduction; src-Family Kinases; Steroids; Transcription, Genetic; Tyrosine

2000
Src tyrosine kinases and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases mediate pressure-induced c-fos expression in cannulated rat mesenteric small arteries.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:3

    Topics: Animals; Arterioles; Benzoquinones; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Flavonoids; Lactams, Macrocyclic; Male; Mesenteric Arteries; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Pressure; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Quinones; Rats; Rats, Wistar; Rifabutin; src Homology Domains; src-Family Kinases

2001
Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase.
    Cancer research, 2001, Feb-15, Volume: 61, Issue:4

    Topics: Benzoquinones; Breast Neoplasms; Cell Movement; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Quinones; Receptor, IGF Type 1; Receptors, Estrogen; Rifabutin; RNA, Messenger; Stimulation, Chemical; Transcription Factor AP-1; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator

2001
Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.
    British journal of pharmacology, 2001, Volume: 132, Issue:7

    Topics: Animals; Benzoquinones; Calcium; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Lactams, Macrocyclic; Lipoproteins, LDL; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Virulence Factors, Bordetella

2001
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
    Cellular signalling, 2001, Volume: 13, Issue:4

    Topics: Androstadienes; Benzoquinones; Blotting, Western; Cell Division; Cells, Cultured; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Indoles; Lactams, Macrocyclic; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Isoforms; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rifabutin; Thrombin; Time Factors; Trachea; Transfection; Virulence Factors, Bordetella; Wortmannin

2001
Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-induced prolongation of rat eosinophil survival.
    Biochimica et biophysica acta, 2001, Apr-30, Volume: 1536, Issue:1

    Topics: Animals; Apoptosis; Benzoquinones; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Enzyme Inhibitors; Eosinophils; Flavonoids; Interleukin-5; Janus Kinase 2; Lactams, Macrocyclic; Male; Milk Proteins; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinones; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Rifabutin; Signal Transduction; STAT5 Transcription Factor; Trans-Activators

2001
Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathway.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:6

    Topics: Animals; Antibodies; Benzoquinones; Cell Division; Cell Line; Cell Movement; CHO Cells; Cricetinae; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor Binding Protein 1; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Oligopeptides; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Quinones; Receptors, Fibronectin; Rifabutin; Signal Transduction; Time Factors; Tissue Distribution; Trophoblasts

2001
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
    Cell biology international, 2001, Volume: 25, Issue:5

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoquinones; Cell Differentiation; Chromones; Cyclic AMP; Enzyme Inhibitors; Flavonoids; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Indoles; Isoproterenol; Isoquinolines; Lactams, Macrocyclic; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sirolimus; Sulfonamides; Tumor Cells, Cultured; Wortmannin

2001
Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide.
    Journal of neurochemistry, 2001, Volume: 78, Issue:3

    Topics: Antioxidants; Benzoquinones; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Lipopolysaccharides; Membrane Proteins; Microglia; Myristoylated Alanine-Rich C Kinase Substrate; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Pyridines; Quinones; Rifabutin; Signal Transduction; src-Family Kinases; Thiocarbamates

2001
p73 is a growth-regulated protein in vascular smooth muscle cells and is present at high levels in human atherosclerotic plaque.
    Cellular signalling, 2001, Volume: 13, Issue:10

    Topics: Arteriosclerosis; Becaplermin; Benzoquinones; Cell Line; Culture Media; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Genes, Tumor Suppressor; Growth Substances; Humans; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Nuclear Proteins; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-sis; Quinones; Rifabutin; RNA, Messenger; Tumor Protein p73; Tumor Suppressor Proteins

2001
Tissue inhibitor of metalloproteinases 1 and 2 directly stimulate the bone-resorbing activity of isolated mature osteoclasts.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001, Volume: 16, Issue:12

    Topics: Acetamides; Animals; Benzoquinones; Bone Resorption; Butadienes; Cells, Cultured; Dipeptides; Flavonoids; Humans; Lactams, Macrocyclic; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Nitriles; Osteoclasts; Protein-Tyrosine Kinases; Quinones; Rabbits; Rifabutin; Succinates; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2

2001
Vanadate increases glucocorticoid receptor-mediated gene expression: a novel mechanism for potentiation of a steroid receptor.
    The Journal of steroid biochemistry and molecular biology, 2002, Volume: 80, Issue:1

    Topics: Animals; Benzoquinones; Cell Fractionation; Cell Line; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Lactams, Macrocyclic; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Quinones; Receptors, Glucocorticoid; Rifabutin; Vanadates

2002
Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Apr-01, Volume: 168, Issue:7

    Topics: Apoptosis; Benzoquinones; Cell Degranulation; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Imidazoles; Kinetics; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Solubility

2002
Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages.
    Glycoconjugate journal, 2001, Volume: 18, Issue:5

    Topics: Androstadienes; Animals; Benzoquinones; Carrier Proteins; Cell Movement; Chondroitin Sulfates; Cytokines; Dermatan Sulfate; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Lactams, Macrocyclic; Macrophages; Mice; Midkine; Protein Tyrosine Phosphatases; Pyrazoles; Pyrimidines; Pyrrolidinones; Quinones; Rats; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Signal Transduction; Wortmannin

2001
Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:2

    Topics: Angiotensin II; Animals; Antibodies; Benzoquinones; Calmodulin-Binding Proteins; Digestive System; Digestive System Physiological Phenomena; Enzyme Inhibitors; Female; Flavonoids; Genistein; In Vitro Techniques; Lactams, Macrocyclic; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; p120 GTPase Activating Protein; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Tyrosine

2002
Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2004, Volume: 97, Issue:3

    Topics: Benzoquinones; Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dental Pulp; Dexamethasone; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Signal Transduction; Sulfonamides

2004
Inhibition of MAPK stimulates the Ca2+ -dependent big-conductance K channels in cortical collecting duct.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Dec-19, Volume: 103, Issue:51

    Topics: Animals; Benzoquinones; Biophysical Phenomena; Biophysics; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Kidney Tubules, Collecting; Lactams, Macrocyclic; Large-Conductance Calcium-Activated Potassium Channels; Male; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Potassium; Rats; Rats, Sprague-Dawley; Rifabutin

2006
[Influence of signal transduction modulators on the secretory function of T lymphocytes in severely scalded mice and its mechanism].
    Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 2006, Volume: 22, Issue:6

    Topics: Animals; Benzoquinones; Burns; Calcimycin; Calcium; Cells, Cultured; Female; Flavonoids; Interleukin-10; Interleukin-2; Lactams, Macrocyclic; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Rifabutin; Signal Transduction; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate

2006
PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation.
    Placenta, 2008, Volume: 29, Issue:10

    Topics: Benzoquinones; Cell Differentiation; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Activation; Female; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pregnancy; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyridines; Pyrimidines; Rifabutin; Signal Transduction; src-Family Kinases; Trophoblasts

2008
Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5.
    Hematology (Amsterdam, Netherlands), 2008, Volume: 13, Issue:4

    Topics: Benzoquinones; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Enzyme Inhibitors; Fibronectins; Flavonoids; Flow Cytometry; Humans; Integrin alpha4beta1; Integrin alpha5beta1; Lactams, Macrocyclic; Leukemia, B-Cell; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Precursor Cells, B-Lymphoid; Rifabutin; src-Family Kinases

2008
[Regulation of invasion behavior of ERK-mediated trophoblast by focal adhesion kinase].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2011, Volume: 36, Issue:6

    Topics: Benzoquinones; Cell Division; Cell Movement; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lactams, Macrocyclic; Phosphorylation; Rifabutin; Signal Transduction; Trophoblasts

2011
Regulation of protease-activated receptor-1 expression in human buccal fibroblasts stimulated with arecoline.
    Head & neck, 2013, Volume: 35, Issue:9

    Topics: Acetylcysteine; Arecoline; Blotting, Western; Cell Culture Techniques; Cholinergic Agonists; Chromones; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Immunohistochemistry; Morpholines; Mouth Mucosa; Nitrobenzenes; Oral Submucous Fibrosis; Receptor, PAR-1; Rifabutin; Sulfonamides

2013
Regulatory Roles of Endogenous Mitogen-Activated Protein Kinases and Tyrosine Kinases in the Pacemaker Activity of Colonic Interstitial Cells of Cajal.
    Pharmacology, 2015, Volume: 96, Issue:1-2

    Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin

2015
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013