pd 98059 has been researched along with genistein in 124 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 34 (27.42) | 18.2507 |
| 2000's | 86 (69.35) | 29.6817 |
| 2010's | 4 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Bitar, R; Dackiw, AP; Davreux, CJ; Lu, Z; McGilvray, ID; Rotstein, OD | 1 |
| Rao, GN | 1 |
| Bánfi, B; Buday, L; Faragó, A; Farkas, G; Geiszt, M; Kapus, A; Ligeti, E; Mócsai, A | 1 |
| D'Agata, ID; Dionne, S; Levesque, D; Levy, E; Ruemmele, FM; Seidman, EG; Srivastava, AK; St-Louis, J | 1 |
| Finlay, BB; Gold, MR; Sutherland, CL; Tang, P | 1 |
| Foncea, R; Lavandero, S; Pérez, V; Sapag-Hagar, M | 1 |
| Linder, S; Ljungdahl, S; Shoshan, MC; Swedenborg, J; Zhou, JN | 1 |
| Matsuoka, T; Nishizaki, T; Nomura, T; Sumikawa, K | 1 |
| Chen, L; Liang, Q; Mohan, RR; Wilson, SE | 1 |
| Foreback, JL; Remick, DG; Sarma, V; Ward, PA; Yeager, NR; Younkin, EM | 1 |
| Bibb, KE; Burns, JM; Lima, MF; Villalta, F; Zhang, Y | 1 |
| Jaakkola, P; Jalkanen, M; Kauppi, T; Kontusaari, S; Määtä, A | 1 |
| Florian, JA; Monroe, KM; Watts, SW | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
| Dryden, WF; Lei, S; Smith, PA | 1 |
| Hamada, Y; Nakahata, N; Nakatani, K; Ohizumi, Y; Tsurufuji, S | 1 |
| Lu, Z; McGilvray, ID; Rotstein, OD; Wei, AC | 1 |
| Inoue, K; Iwasaki, Y; Mutsuga, N; Niiori-Onishi, A; Oiso, Y; Saito, H | 1 |
| Hinoue, T; Kidd, M; Läuffer, JM; Modlin, IM; Schmid, SW; Tang, LH; Zhang, T | 1 |
| Fukuda, K; Ishida, H; Kodama, H; Koura, T; Miyoshi, S; Murata, M; Nakazawa, HK; Ogawa, S | 1 |
| Piper, HM; Schäfer, M; Schlüter, KD; Simm, A; Taimor, G | 1 |
| Fukunaga, K; Kanasaki, H; Miyamoto, E; Miyazaki, K; Takahashi, K | 1 |
| Perkinton, MS; Sihra, TS; Williams, RJ | 1 |
| Creanor, J; Flatman, PW | 1 |
| Ai, W; Gong, J; Yu, L | 1 |
| Grimes, CA; Jope, RS | 1 |
| Bandyopadhyay, G; Burke, TR; Farese, RV; Quon, MJ; Sajan, MP; Standaert, ML | 1 |
| Daniels, I; Fletcher, J; Haynes, AP | 1 |
| Arai, KI; Itoh, T; Liu, R; Watanabe, S | 1 |
| Henrion, D; Lehoux, S; Lévy, BI; Loufrani, L; Tedgui, A | 1 |
| Carvalho, AP; Cruz, MT; Duarte, CB; Gonçalo, M; Lopes, MC | 1 |
| Polk, DB; Tong, W | 1 |
| Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Isumi, Y; Kangawa, K; Katafuchi, T; Kubo, A; Minamino, N | 1 |
| Hanson, L; McManaman, JL; Neville, MC; Wright, RM | 1 |
| Watts, SW | 1 |
| Strayer, DS; White, MK | 1 |
| Arai, K; Liu, CB; Liu, R; Mohi, MG; Watanabe, S | 1 |
| Bansal, R; Baron, W; de Vries, H; Hoekstra, D; Metz, B | 1 |
| Alexander, B; Alexander, JS; Coe, LL; Flores, SC; Joh, T; Oshima, T; Park, JH; Vaitaitis, G; Zhu, Y | 1 |
| Dickenson, JM; Germack, R | 1 |
| Creuzet, C; Dupouy-Camet, J; Robert-Gangneux, F; Roisin, MP | 1 |
| Altura, BM; Altura, BT; Wang, J; Yang, ZW; Zheng, T | 1 |
| Dantin, F; Dubois, F; Mazière, C; Mazière, J; Santus, R | 1 |
| Böhm, M; Geisler, M; Mies, F; Nohr, T; Schnabel, P | 1 |
| Boland, R; Buitrago, C; De Boland, AR; Morelli, S; Vazquez, G | 1 |
| Kitamura, M; Konta, T; Lucio-Cazana, J; Moreno-Manzano, V; Nakayama, K | 1 |
| el-Abbadi, NH; Fathy, TM; Han, S; Kahwaji, CI; Kaka, AH; Purdy, RE; Sheibani, S; Siu, WO | 1 |
| Annunziato, F; Bonacchi, A; Efsen, E; Francalanci, M; Gentilini, P; Laffi, G; Lasagni, L; Marra, F; Pinzani, M; Romagnani, P; Romanelli, RG; Serio, M | 1 |
| Chen, H; Fetscher, C; Heusch, G; Michel, MC; Schäfers, RF; Wambach, G | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D | 1 |
| Sun, HY; Zhao, RR; Zhi, JM | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Pan, SL; Wang, CC; Yang, CM | 1 |
| Aberg, MA; Carlsson, B; Eriksson, PS; Hellgren, G; Lindell, K; MacLennan, AJ; Orwar, O; Rosengren, LE; Ryttsén, F | 1 |
| Hirota, K; Semenza, GL | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Shyr, MH; Wang, CC; Yang, CM | 1 |
| Chong, YH; Chung, JH; Shin, SA; Suh, YH; Sung, JH | 1 |
| Li, H; Wong, WS | 1 |
| Hidari, KI; Kimura, M; Miyamoto, D; Suzuki, T; Suzuki, Y | 1 |
| Roberts, RE | 1 |
| Gu, Z; Jiang, Q; Zhang, G | 1 |
| Garcha, RS; Hughes, AD; Sever, PS | 1 |
| Dreja, K; Hellstrand, P; Hultgårdh-Nilsson, A; Lindqvist, A; Lövdahl, C; Moses, S | 1 |
| Alexander, JS; Grisham, MB; Jordan, P; Laroux, FS; Oshima, T; Pavlick, KP; Verma, SK; Williams, L | 1 |
| Låg, M; Refsnes, M; Schwarze, PE; Thoresen, GH; Thrane, EV | 1 |
| Chen, Y; Jing, Q; Li, X; Pei, G; Qiu, J; Sun, G; Wang, P; Zhang, W; Zhong, Y | 1 |
| Aikawa, R; Gu, Y; Hayashi, D; Kadowaki, T; Komuro, I; Kudoh, S; Uozumi, H; Yamauchi, T; Yazaki, Y; Zhu, W; Zou, Y | 1 |
| Gafni, M; Keren, O; Sarne, Y; Shapira, M | 1 |
| Avkiran, M; Hearse, DJ; Snabaitis, AK | 1 |
| Hussain, T; Lokhandwala, M; Narkar, V | 1 |
| Bompadre, MB; Coso, OA; Fernández, GC; Gómez, S; Isturiz, MA; Palermo, MS; Rosa, FA; Rubel, C | 1 |
| Ho, J; Lau, HK | 1 |
| Fan, YP; Puri, RN; Rattan, S | 2 |
| Bang, JH; Jang, CH; Joo, I; Jung, MW; Kim, C; Kim, SU; Mook-Jung, I | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Araki, Y; Nitto, T; Sendo, F; Takeda, Y | 1 |
| Böcker, D; Verspohl, EJ | 1 |
| Mann, GE; Morgan, AJ; Pearson, JD; Sobrevia, L; Steinert, JR; Sugden, D; Wheeler-Jones, CP; Wyatt, AW | 1 |
| Grinkevich, LN; Lisachev, PD; Merkulova, TI | 1 |
| Hill, MA; Martinez-Lemus, LA; Meininger, GA; Potocnik, SJ | 1 |
| de Champlain, J; El Midaoui, A; Laplante, MA; Wu, R | 1 |
| Francis, JL; Siddiqui, FA; Siddiqui, TF | 1 |
| Dai, J; Remick, DG; Wang, X; Zeng, X | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Hasan, Z; Hussain, R; Mahmood, A; Shah, BH; Young, DB | 1 |
| Duarte, CB; Pereira, DB | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Ingelfinger, JR; Moini, B; Zhang, SL | 1 |
| Kanayama, N; Kobayashi, H; Suzuki, M; Terao, T | 1 |
| Ariga, H; Matsumoto, K; Minamitani, T; Orba, Y; Sato, M; Sawa, H | 1 |
| Anthony, T; Falola, J; Gu, Y; Kim, LT; Liu, Z; Nwariaku, FE; Sarosi, GA; Zhu, X | 1 |
| Armstrong, DD; Burkholder, TJ; Esser, KA; Hornberger, TA; Koh, TJ | 1 |
| Capra, V; Citro, S; Ravasi, S; Rovati, GE | 1 |
| Inoue, A; Takahashi, S; Takeuchi, S | 1 |
| Inanami, O; Kobayashi, S; Kuwabara, M; Maede, Y; Naito, Y; Sato, J; Sato, R; Yamamori, T; Yamato, O | 1 |
| Casanova, M; Cigorraga, SB; Denduchis, B; Diaz, ES; Pellizzari, E | 1 |
| Chen, Y; Wang, Y; Xu, W; Zhang, Z | 1 |
| Chen, ST; Hsu, JR; Huang, HJ; Hung, SP; Lo, CP; Wang, JP | 1 |
| Arcand, M; du Souich, P; Fradette, C; Kourylko, O | 1 |
| Li, YM; Lin, Z; Tang, L | 1 |
| Fazleabas, AT; Ferguson-Gottschall, SD; Jaffe, RC | 1 |
| Li, SN; Xu, YY; Yang, C | 1 |
| Chen, YC; Li, JY; Wang, Y; Xu, WR; Zhang, YL | 1 |
| Kim, ES; Kim, KE; Kim, KW; Lee, KE; Park, JY; Sohn, MH | 1 |
| Domanski, D; Helbing, CC; Ji, L; Skirrow, RC | 1 |
| Seidler, U; Tuo, BG; Wen, GR | 1 |
| Lei, Y; Li, Z; Ming, QZ; Xiao-Mei, W; Ya, K; Yang, L | 1 |
| Barrett, EJ; Liu, Z; Wang, AX; Wang, H | 1 |
| Hu, C; Li, J; Li, Z; Liu, H; Mo, B; Qi, H; Wang, X; Xu, J | 1 |
| Fujii, H; Ishihara, S; Kimura, H; Li, X; Okada, T; Takahashi, N; Torii, K; Yoshida, H | 1 |
| Ishizuka, Y; Nakaseko, C; Nishimura, M; Saito, Y; Yokota, A | 1 |
| Chan, RY; Chen, WF; Guo, DA; Lau, WS; Wong, MS | 1 |
| Adolfo García-Sáinz, J; Alcántara-Hernández, R | 1 |
| Burkholder, TJ | 1 |
| Hong, BZ; Kang, HS; Kim, HG; Kim, HN; Kwak, YG; Ma, TZ; Park, SA | 1 |
| Jeon, YT; Kim, SH; Kim, YB; Lee, SC; Song, YS | 1 |
| Agarwal, V; Asmat, TM; Dierdorf, NI; Hammerschmidt, S; Hauck, CR | 1 |
| Dong, J; He, P; Li, N; Li, W; Sun, T; Zhang, Q; Zhang, Y | 1 |
| Hu, Y; Li, Y; Lin, M; Liu, K; Ma, X; Tian, X; Xu, X; Yao, J; Zhai, X; Zhang, F | 1 |
| Choi, S; Jiao, HY; Jun, JY; Kim, MW; Kim, SW; Lee, MJ; Na, J; Park, CG; Park, IK; Shin, DH; So, I | 1 |
124 other study(ies) available for pd 98059 and genistein
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogen-activated protein kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Fibronectins; Flavonoids; Genistein; Humans; Integrin alpha4beta1; Integrin beta1; Integrins; Isoflavones; NF-kappa B; Nuclear Proteins; Phosphorylation; Receptors, Lymphocyte Homing; Receptors, Very Late Antigen; Thromboplastin; Trans-Activators; Tyrosine; Viral Proteins; Zinc Fingers | 1997 |
Protein tyrosine kinase activity is required for oxidant-induced extracellular signal-regulated protein kinase activation and c-fos and c-jun expression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; GRB2 Adaptor Protein; Hydrogen Peroxide; Isoflavones; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Oxidants; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Signal Transduction | 1997 |
Differential effects of tyrosine kinase inhibitors and an inhibitor of the mitogen-activated protein kinase cascade on degranulation and superoxide production of human neutrophil granulocytes.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Degranulation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Hydroquinones; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides | 1997 |
Tyrosine kinase and MAPK inhibition of TNF-alpha- and EGF-stimulated IEC-6 cell growth.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Genistein; Intestinal Mucosa; Jejunum; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Tumor Necrosis Factor-alpha | 1998 |
Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen-activated protein kinase pathway.
Topics: Androstadienes; Bacterial Toxins; Cytochalasin D; Epithelial Cells; Flavonoids; Genistein; Heat-Shock Proteins; HeLa Cells; Hemolysin Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Listeria monocytogenes; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Wortmannin | 1998 |
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Heart; Heart Ventricles; Insulin-Like Growth Factor I; Myocardium; Phosphorylation; Polyenes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Sirolimus; Staurosporine; Wortmannin | 1998 |
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactinomycin; DNA, Complementary; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Hydroquinones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Okadaic Acid; Phenols; Proto-Oncogene Proteins c-raf; Quinones; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1998 |
Modulation of ACh receptor currents by arachidonic acid.
Topics: Acetylcholine; Animals; Arachidonic Acid; Brain Chemistry; Chick Embryo; Cycloheximide; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Indomethacin; Ion Channel Gating; Isoquinolines; Maleimides; Masoprocol; Membrane Potentials; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Receptors, Nicotinic; Sulfonamides; Torpedo; Xenopus | 1998 |
Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.
Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; Epithelium, Corneal; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Humans; Janus Kinase 1; Naphthalenes; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators | 1998 |
Blood mononuclear cell production of TNF-alpha and IL-8: engagement of different signal transduction pathways including the p42 MAP kinase pathway.
Topics: Calcium; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; GTP-Binding Proteins; Humans; Interleukin-8; Leukocytes, Mononuclear; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1998 |
Signal transduction in human macrophages by gp83 ligand of Trypanosoma cruzi: trypomastigote gp83 ligand up-regulates trypanosome entry through the MAP kinase pathway.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Glycoproteins; Humans; Macrophages; Neuraminidase; Phosphorylation; Signal Transduction; Trypanosoma cruzi; Up-Regulation | 1998 |
Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.
Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Movement; Enhancer Elements, Genetic; Enzyme Inhibitors; Epithelium; Fibroblast Growth Factors; Flavonoids; Gene Expression Regulation; Genistein; Imidazoles; In Vitro Techniques; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteoglycans; Pyridines; Receptors, Growth Factor; Skin Physiological Phenomena; Suramin; Syndecan-1; Syndecans; Transcriptional Activation; Wound Healing | 1998 |
Dissociation of angiotensin II-stimulated activation of mitogen-activated protein kinase kinase from vascular contraction.
Topics: Angiotensin II; Animals; Aorta; Enzyme Activation; Flavonoids; Genistein; In Vitro Techniques; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Nitriles; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tyrphostins; Vasoconstriction | 1998 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
Involvement of Ras/MAP kinase in the regulation of Ca2+ channels in adult bullfrog sympathetic neurons by nerve growth factor.
Topics: Adrenergic Fibers; Age Factors; Animals; Calcium; Calcium Channels; Deoxyadenosines; Enzyme Inhibitors; Flavonoids; Gene Expression; Genistein; Isoenzymes; Isoflavones; Mitogen-Activated Protein Kinase Kinases; Mutagens; Nerve Growth Factors; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rana catesbeiana; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Transcription, Genetic; Type C Phospholipases | 1998 |
Medium change amplifies mitogen-activated protein kinase-mediated prostaglandin E2 synthesis in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Culture Media; Cytosol; Dinoprostone; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Hydrolysis; Mice; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Protein-Tyrosine Kinases; Tyrphostins | 1998 |
MAP-kinase dependent induction of monocytic procoagulant activity by beta2-integrins.
Topics: Blood Coagulation Factors; CD18 Antigens; Cell Line; Cross-Linking Reagents; Enzyme Inhibitors; Flavonoids; Genistein; Humans; In Vitro Techniques; Inflammation Mediators; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Monocytes; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases | 1998 |
Molecular mechanisms of the negative effect of insulin-like growth factor-I on growth hormone gene expression in MtT/S somatotroph cells.
Topics: Androstadienes; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Genistein; Growth Hormone; Growth Inhibitors; Insulin; Insulin-Like Growth Factor I; Luciferases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Transfection; Tumor Cells, Cultured; Wortmannin | 1999 |
Pituitary adenylate cyclase-activating polypeptide modulates gastric enterochromaffin-like cell proliferation in rats.
Topics: Androstadienes; Animals; Cell Division; Cells, Cultured; Colforsin; DNA; Enterochromaffin Cells; Female; Flavonoids; Gastric Mucosa; Gastrins; Genistein; Humans; Neuropeptides; Neurotransmitter Agents; Octreotide; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Signal Transduction; Terfenadine; Vasoactive Intestinal Peptide; Wortmannin | 1999 |
Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, enhances L-type Ca2+ current and [Ca2+]i transient in cardiomyocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Growth Inhibitors; Guinea Pigs; Heart; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 1999 |
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcinogens; Cardiomegaly; Cells, Cultured; Chromones; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Heart Ventricles; Indoles; Isoenzymes; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Wortmannin | 1999 |
Mitogen-activated protein kinase activation by stimulation with thyrotropin-releasing hormone in rat pituitary GH3 cells.
Topics: Androstadienes; Animals; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Hormones; Naphthalenes; Pituitary Neoplasms; Prolactin; Prolactinoma; Rats; Sulfonamides; Thionucleotides; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Wortmannin | 1999 |
Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Arachidonic Acid; Benzodiazepines; Benzothiadiazines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Genistein; GTP-Binding Proteins; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, AMPA; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1999 |
Stimulation of Na+-K+-2Cl- cotransport by arsenite in ferret erythrocytes.
Topics: Animals; Arsenites; Bumetanide; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Chlorides; Edetic Acid; Enzyme Inhibitors; Erythrocytes; Ferrets; Flavonoids; Genistein; Homeostasis; Imidazoles; In Vitro Techniques; Models, Biological; Potassium; Pyridines; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine | 1999 |
MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Maleimides; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Opioid, mu; Recombinant Proteins; Thionucleotides; Transfection; Wortmannin | 1999 |
Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; DNA-Binding Proteins; DNA, Neoplasm; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Immediate-Early Proteins; Indoles; Kinetics; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Transcription Factors; Tumor Cells, Cultured; Valproic Acid | 1999 |
Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adipocytes; Amino Acid Substitution; Androstadienes; Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Epididymis; Flavonoids; Genistein; Insulin; Kinetics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Recombinant Proteins; Signal Transduction; src Homology Domains; Threonine; Wortmannin | 1999 |
Role of p38 in the priming of human neutrophils by peritoneal dialysis effluent.
Topics: Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; In Vitro Techniques; Kidney Failure, Chronic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peritoneal Dialysis; Phospholipases A; Phosphoric Diester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Superoxides | 1999 |
Two distinct signaling pathways downstream of Janus kinase 2 play redundant roles for antiapoptotic activity of granulocyte-macrophage colony-stimulating factor.
Topics: Animals; Apoptosis; Cell Division; Cell Line; Cell Survival; DNA Fragmentation; Flavonoids; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Janus Kinase 2; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; Signal Transduction | 1999 |
Stretch induces mitogen-activated protein kinase activation and myogenic tone through 2 distinct pathways.
Topics: Animals; Benzoquinones; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Genistein; Indoles; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Tonus; Protein Kinase C; Quinones; Rabbits; Rifabutin; Temperature; Vasoconstriction; Veins | 1999 |
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Dendritic Cells; Enzyme Inhibitors; Fetus; Flavonoids; Fluorescent Antibody Technique; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Imidazoles; Interleukin-1; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Skin; Tumor Necrosis Factor-alpha; Tyrphostins | 1999 |
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
Topics: Animals; Cell Division; Cell Line, Transformed; Chemotaxis; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Matrix; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Intestines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Quinazolines; Transforming Growth Factor beta; Type C Phospholipases; Tyrphostins | 1999 |
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine | 1999 |
Adrenomedullin suppresses interleukin-1beta-induced tumor necrosis factor-alpha production in Swiss 3T3 cells.
Topics: 3T3 Cells; Adrenomedullin; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Interleukin-1; Membrane Proteins; Mice; Peptides; Polymerase Chain Reaction; Receptors, Adrenomedullin; Receptors, Peptide; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha; Vasodilator Agents | 1999 |
Lactogenic hormones regulate xanthine oxidoreductase and beta-casein levels in mammary epithelial cells by distinct mechanisms.
Topics: Animals; Caseins; Cell Line; Enzyme Induction; Epidermal Growth Factor; Female; Flavonoids; Genistein; Hydrocortisone; Mammary Glands, Animal; Mice; Mitogen-Activated Protein Kinases; Prolactin; RNA, Messenger; Signal Transduction; Time Factors; Xanthine Dehydrogenase | 2000 |
5-Hydroxytryptamine-induced potentiation of endothelin-1- and norepinephrine-induced contraction is mitogen-activated protein kinase pathway dependent.
Topics: Animals; Arteries; Butadienes; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Norepinephrine; Rats; Serotonin; Tail; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells.
Topics: Animals; Benzoquinones; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genistein; Insulin Receptor Substrate Proteins; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinones; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Rifabutin; Tyrosine | 2000 |
Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF.
Topics: Animals; Apoptosis; bcl-X Protein; Caspases; Cell Line; DNA Damage; DNA Fragmentation; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gamma Rays; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Janus Kinase 2; MAP Kinase Signaling System; Mice; Milk Proteins; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation-Protective Agents; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; STAT5 Transcription Factor; Trans-Activators | 2000 |
PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Pyridines; Pyrrolidinones; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stem Cells | 2000 |
HIV-1 Tat increases endothelial solute permeability through tyrosine kinase and mitogen-activated protein kinase-dependent pathways.
Topics: Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Products, tat; Genistein; HIV; Humans; Immunohistochemistry; Permeability; Phosphotyrosine; Protein Tyrosine Phosphatases; Recombinant Proteins; Signal Transduction; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Involvement of the mitogen-activated protein (MAP) kinase signalling pathway in host cell invasion by Toxoplasma gondii.
Topics: Animals; Bombesin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Mitogen-Activated Protein Kinases; Models, Biological; Signal Transduction; Tetradecanoylphorbol Acetate; Toxoplasma | 2000 |
Low [Mg(2+)](o) induces contraction of cerebral arteries: roles of tyrosine and mitogen-activated protein kinases.
Topics: Animals; Basilar Artery; Butadienes; Dogs; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; In Vitro Techniques; Magnesium; Magnesium Deficiency; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phosphopeptides; Protein-Tyrosine Kinases; Pyridines | 2000 |
Biphasic effect of UVA radiation on STAT1 activity and tyrosine phosphorylation in cultured human keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; DNA; DNA-Binding Proteins; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Keratinocytes; Lipid Peroxidation; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Reactive Oxygen Species; STAT1 Transcription Factor; Thiobarbituric Acid Reactive Substances; Trans-Activators; Transcription, Genetic; Ultraviolet Rays | 2000 |
Differential regulation of phospholipase C-beta isozymes in cardiomyocyte hypertrophy.
Topics: Androstadienes; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Growth Hormone; Insulin-Like Growth Factor I; Isoenzymes; Norepinephrine; Oligonucleotides, Antisense; Phospholipase C beta; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sirolimus; Type C Phospholipases; Wortmannin | 2000 |
Involvement of tyrosine kinase activity in 1alpha,25(OH)2-vitamin D3 signal transduction in skeletal muscle cells.
Topics: Animals; Benzoquinones; Calcitriol; Calcium; Calcium Signaling; Cells, Cultured; Chick Embryo; DNA; Enzyme Activation; Flavonoids; Genistein; Isoenzymes; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Quinones; Rifabutin; Signal Transduction; Type C Phospholipases; Vanadates | 2000 |
Enhancement of TNF-alpha-induced apoptosis by immobilized arginine-glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism.
Topics: Animals; Apoptosis; Benzoquinones; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Genistein; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinases; Mutation; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rats; Rifabutin; Time Factors; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Evidence that simulated microgravity may alter the vascular nonreceptor tyrosine kinase second messenger pathway.
Topics: Animals; Aorta, Abdominal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Hindlimb Suspension; Male; Muscle, Smooth, Vascular; Parasympatholytics; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Second Messenger Systems; Weightlessness | 2000 |
Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes.
Topics: Androstadienes; Antineoplastic Agents; Blood Vessels; Blotting, Western; Cell Division; Cell Movement; Cells, Cultured; Chemotaxis; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genistein; Humans; Ligands; Liver; Mitogen-Activated Protein Kinases; Pericytes; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptors, Chemokine; Receptors, CXCR3; Recombinant Proteins; Signal Transduction; src-Family Kinases; Time Factors; Wortmannin | 2001 |
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction | 2001 |
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction | 2000 |
Insulin-like growth factor I inhibits cardiomyocyte apoptosis and the underlying signal transduction pathways.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; DNA Fragmentation; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genistein; Heart; Hypoxia; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron; Myocardium; Rats; Signal Transduction; Wortmannin | 2000 |
Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.
Topics: Animals; Benzoquinones; Calcium; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Lactams, Macrocyclic; Lipoproteins, LDL; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Virulence Factors, Bordetella | 2001 |
Selective introduction of antisense oligonucleotides into single adult CNS progenitor cells using electroporation demonstrates the requirement of STAT3 activation for CNTF-induced gliogenesis.
Topics: Age Factors; Animals; Astrocytes; Cell Differentiation; Cell Division; Cells, Cultured; Ciliary Neurotrophic Factor; DNA-Binding Proteins; Electroporation; Enzyme Inhibitors; Flavonoids; Gene Expression; Genistein; Glial Fibrillary Acidic Protein; Hippocampus; Janus Kinase 1; Janus Kinase 2; MAP Kinase Signaling System; Oligonucleotides, Antisense; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; STAT3 Transcription Factor; Stem Cells; Trans-Activators; Transfection | 2001 |
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
Topics: Animals; Binding Sites; Cell Hypoxia; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Genistein; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mammals; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Pyridines; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
Topics: Androstadienes; Benzoquinones; Blotting, Western; Cell Division; Cells, Cultured; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Indoles; Lactams, Macrocyclic; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Isoforms; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rifabutin; Thrombin; Time Factors; Trachea; Transfection; Virulence Factors, Bordetella; Wortmannin | 2001 |
Effects of the beta-amyloid and carboxyl-terminal fragment of Alzheimer's amyloid precursor protein on the production of the tumor necrosis factor-alpha and matrix metalloproteinase-9 by human monocytic THP-1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Antibodies; Cell Line; Drug Synergism; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Interferon-gamma; Kinetics; Matrix Metalloproteinase 9; Monocytes; Peptide Fragments; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2001 |
Pertussis toxin activates tyrosine kinase signaling cascade in myelomonocytic cells: a mechanism for cell adhesion.
Topics: Cell Adhesion; Chromones; Dimethyl Sulfoxide; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Kinetics; Lipopolysaccharide Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Transforming Growth Factor beta; Tyrphostins; U937 Cells; Virulence Factors, Bordetella | 2001 |
Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Size; Cholera Toxin; Chromatography, Thin Layer; Enzyme Activation; Flavonoids; G(M1) Ganglioside; Genistein; MAP Kinase Signaling System; Membrane Glycoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Molecular Weight; Neurites; Neurons; PC12 Cells; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Serine-Threonine Kinases; Rats; Receptor, trkA | 2001 |
Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forelimb; Genistein; Isoflavones; Mitogen-Activated Protein Kinases; Nifedipine; Nitriles; Potassium Chloride; Quinoxalines; Receptors, Adrenergic, alpha-2; Signal Transduction; Swine; Vasoconstriction; Vasodilator Agents; Veins; Verapamil | 2001 |
Nuclear translocation of extracellular signal-regulated kinases in neuronal excitotoxicity.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cytoplasm; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Genistein; Glutamic Acid; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Neurotoxins; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sphingosine; Sulfonamides; Vanadates | 2001 |
Mechanism of action of angiotensin II in human isolated subcutaneous resistance arteries.
Topics: Amlodipine; Angiotensin II; Arteries; Benzimidazoles; Biphenyl Compounds; Calcium; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Flavonoids; Genistein; Humans; In Vitro Techniques; Nickel; Norepinephrine; Potassium; Ryanodine; Skin; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Smooth muscle cell response to mechanical injury involves intracellular calcium release and ERK1/ERK2 phosphorylation.
Topics: Animals; Arteries; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Cell Division; Cell Movement; Cells, Cultured; DNA; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Fluphenazine; Genistein; Intracellular Fluid; Ionomycin; Ionophores; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Octanols; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Thapsigargin; Verapamil | 2001 |
Regulation and distribution of MAdCAM-1 in endothelial cells in vitro.
Topics: Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Carbazoles; Cell Adhesion Molecules; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Endothelium; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Genistein; Imidazoles; Immunoglobulins; In Vitro Techniques; Indoles; Inflammatory Bowel Diseases; Intestinal Mucosa; Isoquinolines; Leupeptins; MAP Kinase Signaling System; Mice; Mucoproteins; NF-kappa B; Phenanthridines; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2001 |
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Topics: Androstadienes; Benzylamines; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Epithelial Cells; Flavonoids; Genistein; Humans; Indoles; Interleukin-8; Isoquinolines; Lung; Maleimides; Okadaic Acid; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Sulfonamides; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2001 |
Rapid activation of ERK1/2 mitogen-activated protein kinase by corticosterone in PC12 cells.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Carbazoles; Corticosterone; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Immunoblotting; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; PC12 Cells; Phosphorylation; Protein Kinase C; Rats | 2001 |
Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes.
Topics: Animals; Apoptosis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Heart; Human Growth Hormone; Hydrogen Peroxide; In Situ Nick-End Labeling; Janus Kinase 2; Mitogen-Activated Protein Kinases; Myocardium; Naphthalenes; Oxidants; Oxidative Stress; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Rats, Wistar; Signal Transduction; src-Family Kinases; Tyrphostins | 2001 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase Inhibitors; Diprenorphine; Down-Regulation; Etorphine; Flavonoids; Genistein; GTP-Binding Proteins; Humans; Kidney; MAP Kinase Signaling System; Narcotic Antagonists; Neuroblastoma; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Staurosporine; Teprotide; Transfection; Tritium; Tumor Cells, Cultured | 2001 |
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins | 2002 |
Role of tyrosine kinase and p44/42 MAPK in D(2)-like receptor-mediated stimulation of Na(+), K(+)-ATPase in kidney.
Topics: Animals; Bromocriptine; Bucladesine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Kidney; Kidney Tubules, Proximal; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Stimulation, Chemical; Vanadates | 2002 |
Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway.
Topics: Apoptosis; Benzoquinones; Cell Degranulation; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Imidazoles; Kinetics; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Solubility | 2002 |
Regulation of plasminogen activator inhibitor-1 secretion by urokinase and tissue plasminogen activator in rat epithelioid-type smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Isoquinolines; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Rats; Signal Transduction; src-Family Kinases; Stilbenes; Sulfonamides; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2002 |
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Angiotensin II; Animals; Dose-Response Relationship, Drug; Drug Combinations; Esophagus; Female; Flavonoids; Genistein; Imidazoles; Losartan; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Opossums; Pyridines; Rabbits; Species Specificity; Tyrphostins | 2002 |
Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Astrocytes; Brain; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Fetus; Flavonoids; Genistein; Glial Fibrillary Acidic Protein; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Phorbol 12,13-Dibutyrate; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases | 2002 |
Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles.
Topics: Angiotensin II; Animals; Antibodies; Benzoquinones; Calmodulin-Binding Proteins; Digestive System; Digestive System Physiological Phenomena; Enzyme Inhibitors; Female; Flavonoids; Genistein; In Vitro Techniques; Lactams, Macrocyclic; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; p120 GTPase Activating Protein; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Tyrosine | 2002 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.
Topics: Amidohydrolases; Antioxidants; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Imidazoles; In Vitro Techniques; Neutrophil Activation; Neutrophils; Pyridines; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
Role of protein kinase C, PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genistein; Glucose; GTP-Binding Proteins; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Cell Surface | 2001 |
Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.
Topics: Adenosine; Androstadienes; Arginine; Biological Transport; Butadienes; Calcium; Cells, Cultured; Chromones; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Fetus; Flavonoids; Gene Expression; Genistein; Humans; Hydrogen-Ion Concentration; MAP Kinase Signaling System; Membrane Potentials; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitriles; Phenethylamines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium; Protein Isoforms; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin | 2002 |
Formation of AP-1 transcription factors during learning in Helix.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Casein Kinase II; CCAAT-Enhancer-Binding Proteins; Central Nervous System; DNA-Binding Proteins; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Exoribonucleases; Flavonoids; Genistein; Helix, Snails; Ionophores; Learning; Phorbol Esters; Protein Serine-Threonine Kinases; Serotonin; Transcription Factor AP-1 | 2003 |
Delayed arteriolar relaxation after prolonged agonist exposure: functional remodeling involving tyrosine phosphorylation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arterioles; Calcium; Demecolcine; Enzyme Inhibitors; Flavonoids; Genistein; Male; Microtubules; Norepinephrine; Phosphorylation; Potassium Chloride; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine; Vasoconstrictor Agents; Vasodilation | 2003 |
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Hypertension; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Cardiovascular; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Superoxides; Thioctic Acid; Vasoconstrictor Agents | 2003 |
Hemoglobin induces the production and release of matrix metalloproteinase-9 from human malignant cells.
Topics: Carcinoma; Cycloheximide; Enzyme Inhibitors; Flavonoids; Genistein; Hemoglobins; Humans; Leukemia, Myeloid; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Melanoma; Neoplasm Proteins; Neoplastic Stem Cells; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2003 |
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
The effect of mycobacterial virulence and viability on MAP kinase signalling and TNF alpha production by human monocytes.
Topics: BCG Vaccine; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; Mycobacterium; Phosphorylation; Protein-Tyrosine Kinases; Tumor Necrosis Factor-alpha; Virulence | 2003 |
Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein.
Topics: Animals; Artifacts; Calcium Signaling; Dentate Gyrus; Enzyme Inhibitors; Flavonoids; Genistein; Ion Channels; Long-Term Potentiation; Presynaptic Terminals; Protein-Tyrosine Kinases; Rats; Reproducibility of Results; Synaptic Transmission | 2003 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
Topics: Angiotensin II; Animals; Anthracenes; Blotting, Western; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Kidney; Losartan; Mice; Microscopy, Fluorescence; Onium Compounds; PAX2 Transcription Factor; Phosphorylation; Plasmids; Pyridines; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors; Tyrphostins; Up-Regulation | 2004 |
A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation.
Topics: Binding, Competitive; Cell Line, Tumor; Cell Movement; Collagen; Depression, Chemical; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Laminin; MAP Kinase Signaling System; Membrane Glycoproteins; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Proteoglycans; Structure-Activity Relationship; Transforming Growth Factor beta; Transforming Growth Factor beta1; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitor, Kunitz Soybean; Trypsin Inhibitors; Urokinase-Type Plasminogen Activator | 2004 |
Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Topics: Androstadienes; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Tenascin; Wortmannin | 2004 |
Antiproliferative effects of Src inhibition on medullary thyroid cancer.
Topics: Apoptosis; Carcinoma, Medullary; Cell Division; Cell Line, Tumor; CSK Tyrosine-Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; src-Family Kinases; Thyroid Neoplasms | 2004 |
Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction.
Topics: Animals; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Gadolinium; Genistein; Indoles; Maleimides; Mechanoreceptors; Mechanotransduction, Cellular; Mice; Morpholines; Myoblasts, Skeletal; Paracrine Communication; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Stress, Mechanical; Tensile Strength | 2005 |
Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Bronchi; Cells, Cultured; DNA; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Indoles; Maleimides; Muscle, Smooth; Pyrazoles; Pyrimidines; ras Proteins; Receptors, Thromboxane; Signal Transduction | 2005 |
Insulin-like growth factor-I stimulated DNA replication in mouse endometrial stromal cells.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Chromones; DNA; DNA Replication; Endometrium; Enzyme Inhibitors; Estradiol; Female; Flavonoids; Gene Expression Regulation; Genistein; Insulin-Like Growth Factor I; Mice; Morpholines; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells | 2005 |
Reduction of concanavalin A-induced expression of interferon-gamma by bovine lactoferrin in feline peripheral blood mononuclear cells.
Topics: Animals; Blotting, Western; Cats; Concanavalin A; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Genistein; Interferon-gamma; Interleukin-1; Interleukin-12; Interleukin-12 Subunit p40; Lactoferrin; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Protein Subunits; Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tumor Necrosis Factor-alpha | 2005 |
Type IV collagen induces down-regulation of steroidogenic response to gonadotropins in adult rat Leydig cells involving mitogen-activated protein kinase.
Topics: Aging; Animals; Cells, Cultured; Chorionic Gonadotropin; Collagen Type IV; Cyclic AMP; Down-Regulation; Flavonoids; Genistein; Gonadotropins; Humans; Leydig Cells; Male; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, LH; Steroids; Testosterone | 2005 |
Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 1; Caspase 3; Caspases; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; fas Receptor; Flavonoids; Flow Cytometry; Genistein; Helicobacter pylori; Humans; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Stomach Neoplasms; Time Factors | 2005 |
Genistein-induced neuronal differentiation is associated with activation of extracellular signal-regulated kinases and upregulation of p21 and N-cadherin.
Topics: Butadienes; Cadherins; Cell Differentiation; Cell Line; Cell Line, Tumor; Central Nervous System; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genistein; Humans; Immunoblotting; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Nitriles; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Threonine; Time Factors; Tretinoin; Up-Regulation | 2005 |
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Imidazoles; Immune Sera; Inflammation; Interleukin-6; Male; Mitogen-Activated Protein Kinase 1; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rabbits; Signal Transduction; Turpentine | 2006 |
Effects of different magnitudes of mechanical strain on Osteoblasts in vitro.
Topics: Animals; Carrier Proteins; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genistein; Glycoproteins; Indomethacin; Membrane Glycoproteins; Mice; Osteoblasts; Osteoprotegerin; Protein Kinase Inhibitors; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tensile Strength | 2006 |
Mitogen-activated protein kinase is involved in the progesterone-mediated induction of baboon glycodelin.
Topics: Animals; Base Sequence; Cell Line, Tumor; DNA; Enzyme Inhibitors; Female; Flavonoids; Gene Deletion; Gene Expression Regulation; Genistein; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Papio; Pregnancy Proteins; Progesterone; Promoter Regions, Genetic; Pyridines; Response Elements; Signal Transduction; Transfection; Tyrphostins | 2006 |
Effects of genistein on angiotensin-converting enzyme in rats.
Topics: Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelial Cells; Estrogen Antagonists; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorescent Antibody Technique; Genistein; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selective Estrogen Receptor Modulators; Tamoxifen | 2006 |
H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genistein; Helicobacter pylori; Humans; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Signal Transduction; Stomach Neoplasms | 2006 |
Calcium-calmodulin mediates house dust mite-induced ERK activation and IL-8 production in human respiratory epithelial cells.
Topics: Allergens; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chelating Agents; Dermatophagoides farinae; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Genistein; Humans; Imidazoles; Interleukin-8; Phosphorylation; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2007 |
Genistein prevents thyroid hormone-dependent tail regression of Rana catesbeiana tadpoles by targetting protein kinase C and thyroid hormone receptor alpha.
Topics: Animals; Dimethyl Sulfoxide; Electrophoresis, Gel, Two-Dimensional; Flavonoids; Gene Expression Regulation, Developmental; Genistein; Immunoblotting; Immunoprecipitation; Larva; Organ Culture Techniques; Phosphorylation; Protein Kinase C; Rana catesbeiana; RNA, Messenger; Tail; Thyroid Hormone Receptors alpha; Thyroid Hormones; Triiodothyronine | 2007 |
Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin | 2007 |
Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity.
Topics: Animals; Cell Hypoxia; Cobalt; DNA; Enzyme Induction; Flavonoids; Genistein; Ginkgo biloba; Ginkgolides; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Neuroprotective Agents; PC12 Cells; Plant Extracts; Rats; RNA, Messenger | 2008 |
Insulin signaling stimulates insulin transport by bovine aortic endothelial cells.
Topics: Androstadienes; Animals; Aorta; Cattle; Caveolin 1; Cells, Cultured; Endothelial Cells; Flavonoids; Genistein; Insulin; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Transport; Pyrazoles; Pyrimidines; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha; Wortmannin | 2008 |
Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells.
Topics: Cell Cycle; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Flow Cytometry; G2 Phase; Genistein; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf | 2008 |
A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions.
Topics: Cell Hypoxia; Cells, Cultured; Flavonoids; Genistein; Humans; Inflammation; Kidney Tubules, Proximal; MAP Kinase Kinase 1; Pioglitazone; Plasminogen Activator Inhibitor 1; PPAR gamma; Prostaglandin D2; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Thiazolidinediones; Tumor Necrosis Factor-alpha | 2008 |
Ligation of CD44 leads to killing activity in human peripheral mononuclear cells via MAP kinase and tyrosine kinases.
Topics: Antibodies, Monoclonal; Cell Line, Tumor; Cytotoxicity, Immunologic; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genistein; Humans; Hyaluronan Receptors; Hyaluronic Acid; K562 Cells; Leukocytes, Mononuclear; Macrolides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction | 2008 |
Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells.
Topics: Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Estrogen Receptor alpha; Estrogens; Female; Flavonoids; Genistein; Ginsenosides; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Receptor, IGF Type 1 | 2009 |
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Stretch-induced ERK2 phosphorylation requires PLA2 activity in skeletal myotubes.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Flavonoids; Genistein; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Muscle Fibers, Skeletal; Muscle, Skeletal; Phospholipase A2 Inhibitors; Phospholipases A2; Phosphorylation; Protein Kinase Inhibitors; Stress, Mechanical | 2009 |
Basic fibroblast growth factor increases intracellular magnesium concentration through the specific signaling pathways.
Topics: Androstadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Endothelial Cells; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Humans; Imidazoles; Intracellular Space; Magnesium; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrrolidinones; Signal Transduction; Tyrphostins; Wortmannin | 2009 |
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Topics: Androstadienes; Anthracenes; Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Genistein; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Uterine Cervical Neoplasms; Wortmannin | 2009 |
Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-terminal kinase.
Topics: Animals; Bacterial Adhesion; Bacterial Proteins; Blotting, Western; Cell Line; Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Host-Pathogen Interactions; Humans; JNK Mitogen-Activated Protein Kinases; Microscopy, Confocal; Phosphorylation; Protein Kinase Inhibitors; Receptors, Polymeric Immunoglobulin; RNA Interference; Signal Transduction; src-Family Kinases; Streptococcus pneumoniae; Transfection | 2010 |
Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis.
Topics: Anthracenes; Arthritis, Rheumatoid; Cell Cycle; Cell Proliferation; Cells, Cultured; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase Cell Cycle Checkpoints; Genistein; Humans; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Synovial Membrane; Tumor Necrosis Factor-alpha | 2012 |
Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.
Topics: Antioxidants; Buthionine Sulfoximine; Caco-2 Cells; Flavonoids; Gene Expression; Genistein; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Metabolic Detoxication, Phase II; NF-E2-Related Factor 2; Oxidative Stress; Protein Kinase C; Protoporphyrins; RNA, Messenger; Up-Regulation | 2013 |
Regulatory Roles of Endogenous Mitogen-Activated Protein Kinases and Tyrosine Kinases in the Pacemaker Activity of Colonic Interstitial Cells of Cajal.
Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin | 2015 |