Compounds > pd 98059

pd 98059 and gefitinib

pd 98059 has been researched along with gefitinib in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (54.55)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Barrow, D; Gee, JM; Harper, ME; Hutcheson, IR; Jones, HE; Knowlden, JM; Madden, T; Nicholson, RI; Wakeling, AE1
Campiglio, M; Carotenuto, A; De Luca, A; Maiello, MR; Mancino, M; Menard, S; Napolitano, M; Normanno, N; Viglietto, G1
Hitomi, T; Kawanaka, M; Koyama, M; Matsuzaki, Y; Sakai, T; Yogosawa, S1
Horn, F; Klappenberger, S; Lattrich, C; Ortmann, O; Pfeiler, G; Treeck, O1
Mekada, E; Miyamoto, S; Mizushima, H; Wang, X1
Hao, YY; Iwamori, M; Li, FF; Lin, B; Liu, DW; Liu, JJ; Qi, Y; Zhang, SL; Zhu, LC1
Bollinger, N; Joslin, EJ; Lauffenburger, DA; Opresko, LK; Shankaran, H; Wiley, HS1
Chen, SC; Chiou, SJ; Chuang, LY; Guh, JY; Hwang, CC; Ko, YM; Lin, TD1
Chen, H; Chen, X; Shen, J; Wang, Q; Wu, H; Xie, XJ1
Chen, B; Dai, J; Dong, Q; Fan, C; Fan, Y; Fang, Y; Han, J; Han, S; Li, X; Liu, S; Liu, W; Ma, D; Wu, X; Xiao, Z; Xu, B; Xue, W; Xue, X; Yang, Y; Zhang, H; Zhao, Y1

Other Studies

11 other study(ies) available for pd 98059 and gefitinib

ArticleYear
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells.
    Endocrinology, 2003, Volume: 144, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Division; Dimerization; Drug Resistance, Neoplasm; ErbB Receptors; Flavonoids; Gefitinib; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Receptor, ErbB-2; RNA, Messenger; Tamoxifen; Transforming Growth Factor alpha; Trastuzumab; Tumor Cells, Cultured

2003
The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib.
    Journal of cellular physiology, 2006, Volume: 207, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Female; Flavonoids; Gefitinib; Humans; Inhibitory Concentration 50; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Transfection

2006
ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:5

    Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p15; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Models, Biological; Phosphorylation; Quinazolines; Signal Transduction

2007
Apoptotic effects of signal transduction inhibitors on human tumor cells with different PTEN expression.
    Oncology reports, 2007, Volume: 18, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Estrogen Antagonists; Flavonoids; Gefitinib; Humans; Mitogen-Activated Protein Kinases; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Tamoxifen

2007
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.
    Journal of cell science, 2009, Dec-01, Volume: 122, Issue:Pt 23

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Chromones; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Heparin-binding EGF-like Growth Factor; Humans; Integrins; Intercellular Signaling Peptides and Proteins; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Signal Transduction

2009
Lewis(y) antigen stimulates the growth of ovarian cancer cells via regulation of the epidermal growth factor receptor pathway.
    Oncology reports, 2010, Volume: 23, Issue:3

    Topics: Cell Line, Tumor; Cell Proliferation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fucosyltransferases; Gefitinib; Humans; Lewis Blood Group Antigens; Morpholines; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines

2010
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.
    Molecular bioSystems, 2010, Volume: 6, Issue:7

    Topics: Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Gene Regulatory Networks; Hepatocyte Growth Factor; Humans; Imidazoles; Ligands; Lysophospholipids; Mammary Glands, Human; Phosphorylation; Pyridines; Quinazolines; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha

2010
Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells.
    Translational research : the journal of laboratory and clinical medicine, 2011, Volume: 158, Issue:4

    Topics: Animals; Benzamides; Cell Line; Collagen; Cyclin D1; Dioxoles; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gefitinib; Imidazoles; Kidney; MAP Kinase Signaling System; Mice; Mitosis; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Rats; Receptors, Transforming Growth Factor beta; Smad Proteins; Transforming Growth Factor beta1; Translational Research, Biomedical

2011
Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades.
    Molecular neurobiology, 2019, Volume: 56, Issue:4

    Topics: Animals; Astrocytes; Brain Ischemia; Cell Differentiation; Cell Proliferation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gefitinib; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Memory; Motor Activity; Neural Stem Cells; Neurogenesis; Rats, Sprague-Dawley; Recovery of Function; Saponins; Spheroids, Cellular; Triterpenes

2019
Epidermal growth factor receptor-extracellular-regulated kinase blockade upregulates TRIM32 signaling cascade and promotes neurogenesis after spinal cord injury.
    Stem cells (Dayton, Ohio), 2020, Volume: 38, Issue:1

    Topics: Animals; Cells, Cultured; Cetuximab; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gefitinib; GTP-Binding Proteins; Mice; Mice, Inbred C57BL; Neurogenesis; Neurons; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries; Up-Regulation

2020