Compounds > pd 98059

pd 98059 and dinoprostone

pd 98059 has been researched along with dinoprostone in 74 studies

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (13.51)18.2507
2000's49 (66.22)29.6817
2010's15 (20.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Argast, GM; Bornfeldt, KE; Campbell, JS; Koyama, H; Krebs, EG; Leslie, CC; Raines, EW; Ross, R1
Pyne, NJ; Pyne, S; Tolan, D1
Huh, SO; Kim, YH; Lee, JK; Lee, KJ; Song, DK; Suh, HW; Won, JS1
Hamada, Y; Nakahata, N; Nakatani, K; Ohizumi, Y; Tsurufuji, S1
Jea, JC; Liu, TC; Sung, YJ; Wang, SY1
Hayashi, K; Kubo, M; Kutsuwa, M; Kyo, R; Nakahata, N; Ohizumi, Y1
Arata, J; Dannenberg, AJ; Eling, TE; Inoue, H; Jetten, AM; Kamitani, H; Matsuura, H; Sakaue, M; Subbaramaiah, K; Tanabe, T1
Caput, D; Escoubet, L; Ferrara, P; Pipy, B; Quartulli, F; Rey, A; Sozzani, P1
Fernandes, DJ; Guida, E; Harris, T; Koutsoubos, V; Ravenhall, CE; Schachte, LC; Stewart, AG; Vadiveloo, P; Wilson, JW1
Abraham, JH; Fabry, B; Laporte, JD; Maksym, GN; Moore, PE; Panettieri, RA; Shore, SA1
Barnes, PJ; Cambridge, L; Hart, LA; Lindsay, MA; Newton, R; Stevens, DA1
Fukunaga, K; Kanasaki, H; Miyamoto, E; Miyazaki, K; Munir, I; Ohba, T; Okamura, H1
Choi, YJ; Kwon, TK; Park, JW; Suh, SI1
Atay, S; Kawanaka, H; Pai, R; Soreghan, BA; Szabo, IL; Tarnawski, AS1
Brune, K; Hinz, B; Pahl, A; Ramer, R1
Cho, CH; Fan, XM; Kung, HF; Lam, SK; Lin, MC; Wang, WP; Wong, BC1
Ertl, G; Jacobs, M; Scheuren, N; Schorb, W1
Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Tokuda, H; Uematsu, T1
Doherty, D; Hidalgo, G; Hirschowitz, E1
Kapp, A; Kienlin, P; Mommert, S; Werfel, T; Wittmann, M1
Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niho, Y; Niiro, H; Ogami, E; Otsuka, T; Yamaoka, K1
Demetris, AJ; Han, C; Lunz, JG; Michalopoulos, G; Shelhamer, JH; Wu, T1
Dosoretz, A; Holland, JF; Kirschenbaum, A; Levine, AC; Liu, XH; Lu, M; Yao, S1
Nakahata, N; Nakatani, K; Ohizumi, Y; Ohkubo, S; Tsuchiya, C1
Berenbaum, F; Bereziat, G; Humbert, L; Thirion, S1
Harada, R; Kobayashi, M; Nakata, H; Taguchi, H; Uemura, Y1
Binder, BR; Bochkov, VN; Huber, J; Leitinger, N1
Lai, WC; Peng, G; Shankavaram, U; Wahl, LM; Zhou, M1
Alander, C; Choudhary, S; Pilbeam, CC; Raisz, LG; Wadhwa, S1
Chang, PR; Chen, YJ; Huang, HC; Huang, YT; Sun, YC; Wang, CJ; Wang, FS; Yang, KD; Yang, YJ1
Chen, YC; Hsu, KC; Ko, CH; Shen, SC1
Arakawa, T; Fujiwara, Y; Higuchi, K; Matsumoto, T; Oshitani, N; Sasaki, E; Tarnawski, AS; Tominaga, K; Watanabe, T1
Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niiro, H; Ninomiya, I; Ogami, E; Otsuka, T; Shimizu, S1
Al-Sadi, R; Kreydiyyeh, SI1
Cui, Y; Kim, DS; Kim, SK; Kwon, SB; Park, KC; Park, SH; Yoon, JA1
Chae, HJ; Chae, SW; Kim, HR; Reed, JC1
Hosoe, M; Katoh, T; Komurasaki, T; Mikami, Y; Miyahara, T; Nemoto, N; Sakuma, T; Takayama, K; Uchida, S; Watanabe, M1
Catapano, AL; Inoue, H; Norata, GD; Pellegatta, F; Pirillo, A1
Bland, KI; Chaudry, IH; Jarrar, D; Kuebler, JF; Rue, LW; Song, GY1
Fukushima, H; Jimi, E; Motokawa, W; Okabe, K; Okamoto, F1
Bagnato, A; Di Castro, V; Elia, G; Natali, PG; Rosanò, L; Spinella, F1
Bao, Y; Ding, YB; Li, XY; Shi, RH; Tong, JD; Wang, XH; Wu, J; Xiao, WM; Yan, ZG; Yang, JG; Zhang, GX1
Iwagaki, H; Jikuhara, A; Mori, S; Nishibori, M; Takahashi, HK; Tanaka, N; Yoshii, M1
Hua, XY; Lai, J; Porreca, F; Powell, HC; Svensson, CI; Yaksh, TL1
Goldring, MB; Jalonen, U; Kankaanranta, H; Lahti, A; Leinonen, S; Moilanen, E; Nieminen, R; Vuolteenaho, K1
Nakajin, S; Noda, M; Watanabe, M1
Benetti, E; Collino, M; Dianzani, C; Fantozzi, R; Gallicchio, M; Rosa, AC1
Fischer, SM; He, G; Sung, YM1
Clemente, D; Correa, F; Docagne, F; Guaza, C; Mestre, L1
Ashizuka, M; Ito, S; Kubota, Y; Ogata, S; Satoh, S; Shirasuna, K; Takeuchi, H1
Alique, M; Furusu, A; Kitamura, M; Konta, T; Lucio-Cazaña, FJ; Moreno, V; Nakayama, K; Sepulveda, JC; Xu, Q1
Birnbaumer, L; Edwards, RA; Hoang, B; Trinh, A1
Seidler, U; Tuo, BG; Wen, GR1
Chan, TF; Chen, YH; Chuang, CY; Hsu, SC; Lee, JN; Tsai, EM1
Kadonosono, K; Kamei, J; Ohnaka, K; Tanaka, S; Utsunomiya, H; Yamakawa, T1
Gu, R; Jin, Y; Kong, S; Li, W; Wang, L; Wang, WH; Yang, B; Yang, L; Zhai, Y; Zhang, C; Zhang, Y1
Beyer, C; Etgen, AM; Garcia-Juárez, M; Gómez-Camarillo, MA; Gómora-Arrati, P; González-Flores, O; Lima-Hernández, FJ1
Henkel, J; Neuschäfer-Rube, F; Pathe-Neuschäfer-Rube, A; Püschel, GP1
Chen, CL; Lo, HM; Tsai, YJ; Wu, PH; Wu, WB1
Ara, T; Fujinami, Y; Hattori, T; Honjo, K; Imamura, Y; Wang, PL1
Itabe, H; Kato, R; Obama, T; Sakiyama, Y; Suzuki, K; Usui, M; Yamamoto, M1
Kondo, A; Matsuda, T; Togari, A; Tsunashima, Y1
Chang, CC; Chang, WC; Juo, SH; Wang, YS; Weng, WT; Yoshioka, T1
Aritake, K; Hori, M; Matsuoka, T; Michishita, M; Murata, T; Narumiya, S; Ozaki, H; Tajima, T; Urade, Y1
Chang, JZ; Chen, HM; Deng, YT; Kuo, MY; Yang, WH1
Cao, H; Gu, Y; Wu, Y; Yang, Y; Yin, J; Zhang, L; Zhang, Y; Zhao, X; Zhao, Z; Zhou, Y1
Chung, KW; Kim, GH; Kim, SJ; Lee, WK1
Li, X; Li, Y; Tan, L; Tang, T; Wang, J; Wu, Y; Xu, Z; Yang, P; Zhao, L; Zhao, Z1
Chang, HH; Donald, GW; Eibl, G; Hertzer, KM; Hines, OJ; Jung, XS; Moro, A; Pham, H; Reber, HA; Rodriguez, CE1
Barbosa, BF; Bechi, N; Favoreto-Junior, S; Ferro, EA; Gomes, AO; Ietta, F; Mineo, JR; Mineo, TW; Paulesu, L; Romagnoli, R; Silva, DA1
Cheng, SE; Chi, PL; Hsiao, LD; Hsu, CK; Lee, IT; Yang, CM1
Nemoto, E; Shimauchi, H; Suzuki, R1
Lee, J; Lee, YS; Shehzad, A1
Ettinger, K; Lazarovici, P; Marcinkiewicz, C; Nevo, Y1

Other Studies

74 other study(ies) available for pd 98059 and dinoprostone

ArticleYear
The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.
    The Journal of clinical investigation, 1997, Aug-15, Volume: 100, Issue:4

    Topics: Cell Division; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Indomethacin; Isoenzymes; MAP Kinase Kinase 1; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction

1997
Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.
    The Biochemical journal, 1997, Dec-01, Volume: 328 ( Pt 2)

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cytosol; Dinoprostone; Down-Regulation; Drug Interactions; Flavonoids; Guinea Pigs; Indoles; Indomethacin; Maleimides; Muscle, Smooth; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Trachea

1997
Prostaglandin E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture.
    Brain research. Molecular brain research, 1998, Oct-01, Volume: 60, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic

1998
Medium change amplifies mitogen-activated protein kinase-mediated prostaglandin E2 synthesis in Swiss 3T3 fibroblasts.
    European journal of pharmacology, 1998, Aug-28, Volume: 356, Issue:1

    Topics: 3T3 Cells; Animals; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Culture Media; Cytosol; Dinoprostone; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Hydrolysis; Mice; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Protein-Tyrosine Kinases; Tyrphostins

1998
Nitric oxide enhances the growth of U937 human leukemic cells through a cyclooxygenase-mediated pathway.
    Journal of leukocyte biology, 1998, Volume: 64, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Cycle; Cell Division; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Humans; Indomethacin; Kinetics; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; U937 Cells

1998
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
    The American journal of Chinese medicine, 1998, Volume: 26, Issue:3-4

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavanones; Flavonoids; Glioma; Ionophores; Molecular Sequence Data; Phosphorylation; Prostaglandin Antagonists; Rats; Tumor Cells, Cultured

1998
Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases.
    The Journal of biological chemistry, 1999, Oct-08, Volume: 274, Issue:41

    Topics: Amphiregulin; Carcinoma, Squamous Cell; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; EGF Family of Proteins; Eicosanoids; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gene Expression Regulation, Enzymologic; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Interferon-gamma; Isoenzymes; Keratinocytes; Membrane Proteins; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured

1999
IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production.
    Biochimica et biophysica acta, 1999, Sep-22, Volume: 1440, Issue:2-3

    Topics: Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Dinoprostone; Female; Flavonoids; Interleukin-13; Lipoxygenase; Macrophages, Peritoneal; Mice; Phospholipases A; Phosphorylation; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Serine; Signal Transduction; Zymosan

1999
Beta2-adrenergic receptor agonists and cAMP arrest human cultured airway smooth muscle cells in the G(1) phase of the cell cycle: role of proteasome degradation of cyclin D1.
    Molecular pharmacology, 1999, Volume: 56, Issue:5

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Calpain; Cells, Cultured; Cyclin D1; Cysteine Endopeptidases; Dinoprostone; DNA; Flavonoids; G1 Phase; Gene Expression Regulation; Humans; Leupeptins; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Muscle, Smooth; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Retinoblastoma Protein; RNA, Messenger; S Phase; Thrombin; Time Factors

1999
Role of ERK MAP kinases in responses of cultured human airway smooth muscle cells to IL-1beta.
    The American journal of physiology, 1999, Volume: 277, Issue:5

    Topics: Blotting, Western; Bronchodilator Agents; Bucladesine; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-1; Isoenzymes; Isoproterenol; Magnetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Membrane Proteins; Microspheres; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Adrenergic, beta; Trachea

1999
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
    British journal of pharmacology, 2000, Volume: 130, Issue:6

    Topics: Arachidonic Acid; Butadienes; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Time Factors; Tumor Cells, Cultured

2000
Expression of cyclooxygenase 2 by prostaglandin E(2) in human endometrial adenocarcinoma cell line HEC-1B.
    Biology of reproduction, 2000, Volume: 63, Issue:3

    Topics: Adenocarcinoma; Cyclooxygenase 2; Dinoprostone; Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression; Humans; Immunohistochemistry; Isoenzymes; Isoquinolines; Kinetics; Membrane Proteins; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sulfonamides; Tumor Cells, Cultured

2000
Involvement of ERK and protein tyrosine phosphatase signaling pathways in EGCG-induced cyclooxygenase-2 expression in Raw 264.7 cells.
    Biochemical and biophysical research communications, 2001, Aug-31, Volume: 286, Issue:4

    Topics: Animals; Catechin; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Isoenzymes; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Tyrosine Phosphatases; RNA, Messenger; Signal Transduction; Up-Regulation; Vanadates

2001
PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways.
    Biochemical and biophysical research communications, 2001, Sep-07, Volume: 286, Issue:5

    Topics: Animals; Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Lymphokines; Microcirculation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Muscle, Smooth; Neovascularization, Pathologic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Time Factors; Transcriptional Activation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
    Biochemical and biophysical research communications, 2001, Sep-07, Volume: 286, Issue:5

    Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella

2001
Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways.
    Journal of gastroenterology and hepatology, 2001, Volume: 16, Issue:10

    Topics: Adenocarcinoma; Blotting, Western; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Up-Regulation

2001
Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction.
    Journal of molecular and cellular cardiology, 2002, Volume: 34, Issue:1

    Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Egg Proteins; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Imidazoles; Immunoblotting; Immunoenzyme Techniques; Immunohistochemistry; Isoenzymes; Lactones; Macrophages; Membrane Glycoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Necrosis; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Sulfones; Time Factors; Vimentin; Zona Pellucida Glycoproteins

2002
Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.
    The Journal of endocrinology, 2002, Volume: 172, Issue:2

    Topics: Analysis of Variance; Animals; Butadienes; Calcium; Calcium Channel Blockers; Cell Line; Chelating Agents; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Gallic Acid; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Chaperones; Naphthalenes; Neoplasm Proteins; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Staurosporine; Stimulation, Chemical; Time Factors; Type C Phospholipases

2002
Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors.
    Gene therapy, 2002, Volume: 9, Issue:1

    Topics: Adenoviridae; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured

2002
Suppression of IL-12 production by soluble CD40 ligand: evidence for involvement of the p44/42 mitogen-activated protein kinase pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Apr-15, Volume: 168, Issue:8

    Topics: Apoptosis; CD40 Ligand; Cells, Cultured; Dinoprostone; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-10; Interleukin-12; Interleukin-4; Ligands; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Receptors, Tumor Necrosis Factor; RNA, Messenger; Solubility

2002
Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines.
    International immunology, 2002, Volume: 14, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction

2002
Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:2

    Topics: Arachidonic Acids; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprost; Dinoprostone; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-6; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Nitrobenzenes; Organophosphonates; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Tumor Cells, Cultured

2002
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.
    The Journal of biological chemistry, 2002, Dec-20, Volume: 277, Issue:51

    Topics: Active Transport, Cell Nucleus; Arachidonic Acid; Catalysis; Cell Nucleus; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Green Fluorescent Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Intercellular Signaling Peptides and Proteins; Isoenzymes; Luminescent Proteins; Lymphokines; Male; MAP Kinase Signaling System; Meloxicam; Membrane Proteins; Nitrobenzenes; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thiazines; Thiazoles; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
    European journal of pharmacology, 2003, Feb-07, Volume: 461, Issue:1

    Topics: Animals; Cell-Free System; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavanones; Flavonoids; Glioma; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin Antagonists; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Rats; Tumor Cells, Cultured

2003
Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.
    The Journal of biological chemistry, 2003, Apr-18, Volume: 278, Issue:16

    Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Biological Transport; Blotting, Western; Cartilage, Articular; Chondrocytes; Cytoplasm; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Activation; Female; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Pyridines; Rabbits; Signal Transduction; Time Factors

2003
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
    Cancer science, 2003, Volume: 94, Issue:2

    Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Drug Screening Assays, Antitumor; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Pyridines; Recombinant Proteins; Sulfonamides; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2003
The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways.
    Antioxidants & redox signaling, 2003, Volume: 5, Issue:2

    Topics: Arteriosclerosis; Blotting, Western; Cell Adhesion; Cell Communication; Cells, Cultured; Coculture Techniques; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; Isoprostanes; Leukocytes; Mitogen-Activated Protein Kinases; Monocytes; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Signal Transduction; Time Factors

2003
Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Jun-15, Volume: 170, Issue:12

    Topics: Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoenzymes; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyridines; Transcription Factors

2003
Extracellular calcium is a potent inducer of cyclo-oxygenase-2 in murine osteoblasts through an ERK signaling pathway.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2003, Volume: 18, Issue:10

    Topics: Alkaline Phosphatase; Animals; Blotting, Northern; Blotting, Western; Calcium; Cations; Cell Differentiation; Cyclooxygenase 2; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Isoenzymes; Luciferases; Mice; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphorylation; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic

2003
Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts.
    The Journal of biological chemistry, 2004, Mar-12, Volume: 279, Issue:11

    Topics: Cell Differentiation; Cell Division; Cell Nucleus; Cells, Cultured; Cytosol; Dinoprostone; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Neovascularization, Physiologic; Nitric Oxide; Osteoblasts; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-raf; rac1 GTP-Binding Protein; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Superoxides; Time Factors; Transcription Factors; Transfection; Vascular Endothelial Growth Factor A

2004
3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 production.
    International journal of cancer, 2004, Feb-10, Volume: 108, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; Cell Division; Colony-Forming Units Assay; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured

2004
COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:12

    Topics: Animals; Blotting, Western; Cell Division; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epidermal Growth Factor; Flavonoids; Gastric Mucosa; Isoenzymes; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Signal Transduction; Stomach; Sulfonamides

2003
Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Feb-15, Volume: 172, Issue:4

    Topics: Antibodies, Monoclonal; Carrier Proteins; CD40 Antigens; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Ligands; MAP Kinase Signaling System; Membrane Proteins; Monocytes; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyridines; Recombinant Proteins; Repressor Proteins; Sulfonamides

2004
The signal transduction pathway that mediates the effect of interleukin-1 beta on the Na+-K+-ATPase in LLC-PK1 cells.
    Pflugers Archiv : European journal of physiology, 2004, Volume: 448, Issue:2

    Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dinoprostone; Diuresis; Enzyme Inhibitors; Flavonoids; Indomethacin; Interleukin-1; LLC-PK1 Cells; Mitogen-Activated Protein Kinases; Natriuresis; NF-kappa B; Proline; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Swine; Thiocarbamates

2004
Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells.
    Chemistry and physics of lipids, 2004, Volume: 129, Issue:1

    Topics: Amidines; Catechin; Chromans; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Kinase 4; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines

2004
Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts.
    Immunopharmacology and immunotoxicology, 2004, Volume: 26, Issue:1

    Topics: Animals; Antioxidants; Blotting, Western; Cell Line; Cyclooxygenase 2; Dinoprostone; Electrophoretic Mobility Shift Assay; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; I-kappa B Proteins; Interferon-gamma; Isoenzymes; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Osteoblasts; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Signal Transduction; Sodium Salicylate; Tumor Necrosis Factor-alpha

2004
Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.
    Toxicology, 2004, Aug-05, Volume: 200, Issue:2-3

    Topics: Animals; Blotting, Western; Cadmium; Dinoprostone; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kinetics; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; Phospholipases A; Phospholipases A2; Phosphorylation; Pregnancy; Protein Kinase C; Pyridines; Signal Transduction

2004
Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesis.
    International journal of molecular medicine, 2004, Volume: 14, Issue:3

    Topics: Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Immunoassay; Immunoblotting; Immunohistochemistry; Indomethacin; Lipoproteins, LDL; Membrane Proteins; NF-kappa B; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane A2; Time Factors; Umbilical Veins

2004
The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels.
    Archives of surgery (Chicago, Ill. : 1960), 2004, Volume: 139, Issue:8

    Topics: Analysis of Variance; Animals; Dinoprostone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Glutathione Transferase; Interleukin-6; Laparotomy; Liver; Male; Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Wounds and Injuries

2004
IL-1-induced receptor activator of NF-kappa B ligand in human periodontal ligament cells involves ERK-dependent PGE2 production.
    Bone, 2005, Volume: 36, Issue:2

    Topics: Animals; Carrier Proteins; Cells, Cultured; Coculture Techniques; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycoproteins; Humans; Interleukin-1; Membrane Glycoproteins; Mice; NF-kappa B; Osteoprotegerin; Periodontal Ligament; Periodontium; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor

2005
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Induction; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Tyrphostins

2004
PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.
    Experimental oncology, 2005, Volume: 27, Issue:2

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Oxytocics; Phosphorylation; Quinazolines; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Transcriptional Activation; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Vascular Endothelial Growth Factor A

2005
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
    Journal of pharmacological sciences, 2005, Volume: 98, Issue:4

    Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Guanidines; Humans; Immunohistochemistry; Indomethacin; Mast Cells; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrobenzenes; Phosphorylation; Prostaglandins; Receptor, PAR-2; Serine Endopeptidases; Sulfonamides; Tryptases

2005
Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase.
    Neuropeptides, 2005, Volume: 39, Issue:5

    Topics: Animals; Dinoprostone; Dynorphins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Injections, Spinal; Male; Microglia; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphorylation; Rats; Rats, Sprague-Dawley; Spinal Cord

2005
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes.
    Mediators of inflammation, 2005, Oct-24, Volume: 2005, Issue:5

    Topics: Anthracenes; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Signal Transduction

2005
Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells.
    The Journal of endocrinology, 2006, Volume: 188, Issue:1

    Topics: Adrenal Cortex Neoplasms; Alprostadil; Aromatase; Benzylamines; Cell Line, Tumor; Dinoprost; Dinoprostone; Epidermal Growth Factor; Exons; Flavonoids; Humans; Isoquinolines; Promoter Regions, Genetic; Prostaglandins; Prostaglandins A; Prostaglandins E; Protein Kinase Inhibitors; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stimulation, Chemical; Sulfonamides

2006
Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells.
    British journal of pharmacology, 2006, Volume: 147, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Benzamides; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Furans; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin-1 Receptor Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors; Umbilical Veins

2006
Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes.
    Prostaglandins, leukotrienes, and essential fatty acids, 2006, Volume: 74, Issue:3

    Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Chromans; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Keratinocytes; Mice; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptors; Phosphorylation; PPAR gamma; Protein Kinase Inhibitors; RNA, Messenger; Thiazolidinediones; Troglitazone

2006
The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection.
    Biochemical pharmacology, 2006, Sep-28, Volume: 72, Issue:7

    Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cell Nucleus; Cell Survival; Chromones; Cyclooxygenase 2; Dinoprostone; Endocannabinoids; Endothelial Cells; Enzyme Activation; Flavonoids; Fluorescent Antibody Technique; Glycerides; Imidazoles; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Theilovirus

2006
Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts.
    Biochemical and biophysical research communications, 2006, Dec-29, Volume: 351, Issue:4

    Topics: Anthracenes; Bone and Bones; Calcium; Calcium Signaling; Cations, Divalent; Cyclooxygenase 2; Dinoprostone; Estrenes; Fibroblasts; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Receptors, Calcium-Sensing; RNA, Messenger; Type C Phospholipases

2006
Upregulation of cyclooxygenases by retinoic acid in rat mesangial cells.
    Pharmacology, 2007, Volume: 79, Issue:1

    Topics: Animals; Benzoates; Biphenyl Compounds; Blotting, Northern; Blotting, Western; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Flavonoids; Humans; Interleukin-1beta; Male; MAP Kinase Kinase 1; Mesangial Cells; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Retinoid X Receptors; Retinoids; RNA, Messenger; Time Factors; Tretinoin; Up-Regulation

2007
Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:6

    Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Cells, Cultured; Colon; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; GTP-Binding Protein alpha Subunit, Gi2; Imidazoles; Interleukin-11; Interleukin-1beta; Intestine, Small; Methyl Ethers; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta

2007
Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:1

    Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin

2007
Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells.
    Fertility and sterility, 2008, Volume: 89, Issue:5 Suppl

    Topics: Adult; Cells, Cultured; Chorionic Gonadotropin; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Drug Interactions; Enzyme Inhibitors; Female; Flavonoids; Hormone Antagonists; Humans; JNK Mitogen-Activated Protein Kinases; Luteal Cells; Mifepristone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger

2008
Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway.
    Biomedical research (Tokyo, Japan), 2008, Volume: 29, Issue:1

    Topics: Animals; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Imidazoles; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides

2008
PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney.
    Kidney international, 2008, Volume: 74, Issue:4

    Topics: Animals; Cells, Cultured; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kidney; Kidney Cortex; Male; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Specific Pathogen-Free Organisms

2008
Nitric oxide and ERK/MAPK mediation of estrous behavior induced by GnRH, PGE2 and db-cAMP in rats.
    Physiology & behavior, 2009, Mar-23, Volume: 96, Issue:4-5

    Topics: Analysis of Variance; Animals; Carbazoles; Cyclic AMP; Dinoprostone; Enzyme Inhibitors; Estrous Cycle; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gonadotropin-Releasing Hormone; Guanylate Cyclase; Injections, Intraventricular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Sexual Behavior, Animal; Signal Transduction; Statistics, Nonparametric

2009
Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:3

    Topics: Animals; Cell Line; Cells, Cultured; Dinoprostone; Flavonoids; Hepatocytes; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; Liver Glycogen; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins

2009
Thrombin induces cyclooxygenase-2 expression and prostaglandin E2 release via PAR1 activation and ERK1/2- and p38 MAPK-dependent pathway in murine macrophages.
    Journal of cellular biochemistry, 2009, Dec-01, Volume: 108, Issue:5

    Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Imidazoles; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Thrombin; Thromboxane A2

2009
Preventive effects of a kampo medicine, orento on inflammatory responses in lipopolysaccharide treated human gingival fibroblasts.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:4

    Topics: Acetyltransferases; Anti-Inflammatory Agents; Cell Proliferation; Cell Survival; Dinoprostone; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Electrophoresis, Polyacrylamide Gel; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gingiva; Humans; Inflammation; Interleukins; Lipopolysaccharides; Magnoliopsida; Medicine, Kampo; Periodontal Diseases; Phosphorylation; Phytotherapy; Transcription Factors

2010
Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.
    Journal of periodontal research, 2010, Volume: 45, Issue:4

    Topics: Cell Line, Tumor; Chemokine CCL2; Cholesterol 7-alpha-Hydroxylase; Dextran Sulfate; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fucose; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Ketocholesterols; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Periodontitis; Polysaccharides; Pyridines; Receptors, Scavenger; Sulfuric Acid Esters

2010
Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:5

    Topics: Adult; Anticoagulants; Bone Neoplasms; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Male; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Osteoblasts; Osteocalcin; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Protein Kinase Inhibitors; Pyridines; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sulfonamides; Vitamin K; Vitamins; Warfarin; Young Adult

2010
Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells.
    Toxicology, 2011, Jan-11, Volume: 279, Issue:1-3

    Topics: Aorta; Cell Line; Cell Membrane; Cyclooxygenase 2; Dinoprostone; ErbB Receptors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Lead; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitrates; Phospholipases A2, Cytosolic; Phosphorylation

2011
EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Mar-01, Volume: 302, Issue:5

    Topics: Animals; Carbazoles; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Flavonoids; Gastrointestinal Motility; Ileum; Isoxazoles; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase Type II; Pyrroles; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfones; Up-Regulation

2012
EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts.
    Clinical oral investigations, 2013, Volume: 17, Issue:2

    Topics: Anthracenes; Benzamides; Catechin; Cell Line; Cells, Cultured; Connective Tissue Growth Factor; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; MAP Kinase Kinase 4; Mouth Mucosa; Oral Submucous Fibrosis; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1

2013
Effects of vascular endothelial cells on osteogenic differentiation of noncontact co-cultured periodontal ligament stem cells under hypoxia.
    Journal of periodontal research, 2013, Volume: 48, Issue:1

    Topics: Adult; Alkaline Phosphatase; Animals; Calcification, Physiologic; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Core Binding Factor Alpha 1 Subunit; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Periodontal Ligament; Pyridines; Sp7 Transcription Factor; Stem Cells; Transcription Factors; Vascular Endothelial Growth Factor A

2013
Gallotannin causes differentiation and inflammation via ERK‑1/‑2 and p38 kinase pathways in rabbit articular chondrocytes.
    Molecular medicine reports, 2013, Volume: 7, Issue:2

    Topics: Animals; Cartilage, Articular; Cell Differentiation; Cells, Cultured; Chondrocytes; Collagen Type II; Cyclooxygenase 2; Dinoprostone; Flavonoids; Hydrolyzable Tannins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteochondritis; p38 Mitogen-Activated Protein Kinases; Rabbits; Signal Transduction

2013
Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia.
    Journal of periodontology, 2013, Volume: 84, Issue:12

    Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelial Cells; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nitrobenzenes; Osteogenesis; Periodontal Ligament; Prostaglandin Antagonists; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Stem Cells; Sulfonamides; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A; Xanthones

2013
miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells.
    Biochemical and biophysical research communications, 2013, Sep-13, Volume: 439, Issue:1

    Topics: Butadienes; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinases; MicroRNAs; Nitriles; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; RNA Stability; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors

2013
Susceptibility to Toxoplasma gondii proliferation in BeWo human trophoblast cells is dose-dependent of macrophage migration inhibitory factor (MIF), via ERK1/2 phosphorylation and prostaglandin E2 production.
    Placenta, 2014, Volume: 35, Issue:3

    Topics: Antigens, Protozoan; Cell Line, Tumor; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Macrophage Migration-Inhibitory Factors; Phosphorylation; Toxoplasma; Toxoplasmosis; Trophoblasts

2014
TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2014, Mar-15, Volume: 306, Issue:6

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dinoprostone; E1A-Associated p300 Protein; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Humans; Janus Kinase 2; Lung; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A2; Phosphorylation; Pneumonia; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrphostins

2014
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
    Experimental cell research, 2014, Apr-15, Volume: 323, Issue:1

    Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult

2014
Autocrine prostaglandin E₂ signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway.
    BMB reports, 2015, Volume: 48, Issue:2

    Topics: Apoptosis; Autocrine Communication; Caspase 3; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Flavonoids; HL-60 Cells; Humans; Indomethacin; Isoquinolines; Lamin Type B; Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfonamides; Vitamin K 3

2015
Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2.
    Journal of basic and clinical physiology and pharmacology, 2015, Volume: 26, Issue:4

    Topics: Cell Line; Dinoprostone; Disintegrins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Integrins; Ischemia; MAP Kinase Signaling System; Muscle Fibers, Skeletal; Nerve Growth Factor; Protective Agents

2015