pd 98059 has been researched along with bisindolylmaleimide i in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 32 (22.70) | 18.2507 |
| 2000's | 99 (70.21) | 29.6817 |
| 2010's | 10 (7.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Glembotski, CC; Hanford, DS | 1 |
| Avdi, NJ; Johnson, GL; Russel, M; Winston, BW; Worthen, GS; Young, SK | 1 |
| Beltman, J; Cadwallader, K; Cook, S; McCormick, F | 1 |
| Cox, ME; Parsons, SJ | 1 |
| Häussinger, D; Kurz, AK; Schliess, F; vom Dahl, S | 1 |
| Stepan, VM; Takeuchi, Y; Todisco, A; Urumov, A; Yamada, J; Yamada, T | 1 |
| Freissmuth, M; Hutter, C; Karel, A; Schütz, W; Sexl, V; Zezula, J | 1 |
| Almazan, G; Larocca, JN | 1 |
| Buxbaum, JD; Czernik, AJ; Desdouits, F; Desdouits-Magnen, J; Greengard, P; Nairn, AC; Saltiel, AR; Syu, LJ; Takeda, S | 1 |
| Besson, P; Fernandez-Rachubinski, F; Fliegel, L; Yang, W | 1 |
| Kucera, GL; Stadheim, TA | 1 |
| de Jonge, HR; Dorrestijn, J; Maassen, JA; Narumiya, S; Tilly, BC; van der Wijk, T | 1 |
| Matsuoka, T; Nishizaki, T; Nomura, T; Sumikawa, K | 1 |
| Adams, JW; Brown, JH; Henderson, SA; Sah, VP | 1 |
| Jones, MK; Sarfeh, IJ; Tarnawski, AS | 1 |
| Nagarkatti, DS; Sha'afi, RI | 1 |
| Conn, PM; Lin, X | 1 |
| Haneda, M; Ishida, T; Kikkawa, R; Koya, D; Maeda, S | 1 |
| Johnson, C; Kalra, VK; Shen, Y; Sultana, C | 1 |
| Almazan, G; Larocca, JN; Liu, HN | 1 |
| Enikolopov, G; Matsuoka, T; Nishizaki, T; Nomura, T; Sumikawa, K | 1 |
| Shibuya, M; Takahashi, T; Ueno, H | 1 |
| Chen, N; Dong, Z; Huang, C; Ma, Wy | 1 |
| Itoh, H; Kaiura, TL; Kent, KC | 1 |
| Claesson-Welsh, L; Kanda, S; Klint, P; Kloog, Y | 1 |
| Maurer, RA; Wang, YH | 1 |
| Ai, W; Gong, J; Yu, L | 1 |
| Grimes, CA; Jope, RS | 1 |
| Badimon, L; Martínez-González, J; Viñals, M | 1 |
| Behrens, MM; Choi, DW; Gwag, BJ; Koh, JY; Strasser, U | 1 |
| Becker, M; Cato, AC; Klocker, H; Mink, S; Peterziel, H; Schonert, A | 1 |
| Alessi, DR; Fahlman, R; Krook, A; Ryder, JW; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Avkiran, M; Snabaitis, AK; Yokoyama, H | 1 |
| Bilney, A; Ferrante, A; Hii, CS; Huang, ZH; Murray, AW; Rathjen, DA; Stacey, K | 1 |
| Chien, CS; Chiu, CT; Lin, CC; Luo, SF; Tu, MT; Wang, CC; Yang, CM | 1 |
| Sha'afi, RI; Tandon, R; Thrall, RS | 1 |
| Akkerman, JW; Gorter, G; van Willigen, G | 1 |
| Chen, Y; Deng, J; Wu, R | 1 |
| Abe, M; Ito, M; Kanno, S; Oda, N; Sato, Y; Shibuya, M; Shitara, K; Tabayashi, K; Terai, Y | 1 |
| Abbott, KL; Berts, A; Lee, D; Minneman, KP; Murphy, TJ; Zhong, H | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Enjalbert, A; Gérard, C; Le Péchon-Vallée, C; Magalon, K; Rasolonjanahary, R | 1 |
| Daimon, M; Hirata, A; Igarashi, M; Kato, T; Tominaga, M; Yamaguchi, H | 1 |
| Codogno, P; El Benna, J; Ogier-Denis, E; Pattingre, S | 1 |
| Li, P; Matsunaga, K; Ohizumi, Y; Yamakuni, T | 1 |
| Haskard, DO; Lidington, EA; Mason, JC | 1 |
| Dewas, C; El-Benna, J; Fay, M; Gougerot-Pocidalo, MA | 1 |
| Awasthi, V; King, RJ | 1 |
| Boos, MD; Chini, CC; Dick, CJ; Leibson, PJ; Schoon, RA | 1 |
| Doggett, TA; Lemker, JL; Partridge, NC; Swarthout, JT | 1 |
| Matsuoka, T; Matsushita, S; Tabata, H | 1 |
| Wenner, CE; Yan, S | 1 |
| Chen, H; Fetscher, C; Heusch, G; Michel, MC; Schäfers, RF; Wambach, G | 1 |
| Kaneda, N; Murata, T; Niimi, Y | 1 |
| Akimoto, K; Hattori, Y; Kakishita, H; Kasai, K; Matsumura, M | 1 |
| Aso, T; Kubota, T; Morita, I; Murota, S; Taniguchi, Y | 1 |
| Asahi, KI; Honma, Y; Ishii, Y; Tomoyasu, S; Yamada, K; Yamamoto-Yamaguchi, Y | 1 |
| Grant, S; Vrana, JA | 1 |
| Bauer, CK; Schledermann, W; Schwarz, JR; Wulfsen, I | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Shyr, MH; Wang, CC; Yang, CM | 1 |
| Chang, LC; Wang, JP | 1 |
| Hamada, H; Shimizu, T; Sugibayashi, R; Suzuki, T; Takeda, K; Yamamoto, N | 1 |
| Claes, P; Grobben, B; Roymans, D; Slegers, H | 1 |
| Chung, SW; Kang, SN; Kim, TS | 1 |
| Inanami, O; Kuwabara, M; Tsuji, M | 1 |
| Csermely, P; Kéri, G; Lankenau, A; Steták, A; Ullrich, A; Vántus, T | 1 |
| Amin, AR; Hamaguchi, M; Ichigotani, Y; Kikkawa, F; Nawa, A; Sein, TT; Thant, AA; Zhang, Y | 1 |
| Ahn, YS; Chong, SA; Chung, KC; Lee, SI; Seo, JT; Seo, SR; Sung, JY | 1 |
| Asakura, M; Asanuma, H; Fukushima, T; Hori, M; Kitakaze, M; Kuzuya, T; Liao, Y; Mori, H; Node, K; Ogai, A; Ogita, H; Papst, PJ; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S; Terada, N; Yamada, J | 1 |
| Låg, M; Refsnes, M; Schwarze, PE; Thoresen, GH; Thrane, EV | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Lynch, OT | 1 |
| Hong, HY; Varvayanis, S; Yen, A | 1 |
| Bang, OS; Kang, SS; Park, JH | 1 |
| Frey, BM; Frey, FJ; Heiniger, CD; Rochat, MK | 1 |
| Abe, T; Bamba, T; Kimura, T; Minamiguchi, H; Miyazaki, H; Sonoda, Y; Urata, Y | 1 |
| Audigier, Y; Knibiehler, B; Lahlou, H; Masri, B; Mazarguil, H | 1 |
| Avkiran, M; Hearse, DJ; Snabaitis, AK | 1 |
| Lazou, A; Markou, T | 1 |
| Bang, JH; Jang, CH; Joo, I; Jung, MW; Kim, C; Kim, SU; Mook-Jung, I | 1 |
| Cruciani, V; Mikalsen, SO | 1 |
| Ino, K; Kajiyama, H; Kikkawa, F; Mizutani, S; Shibata, K; Suzuki, T; Uehara, C | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Amit, T; Bar-Am, O; Weinstock, M; Yogev-Falach, M; Youdim, MB | 1 |
| Hanson, DA; Ziegler, SF | 1 |
| Chen, ZC; Jing, ZZ; Li, JL; Xiao, ZQ; Zhu, JH | 1 |
| Frank, SJ; Huang, Y; Jiang, J; Kim, SO | 1 |
| Kageyama, K; Suda, T | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Andoh, A; Bamba, T; Fujiyama, Y; Hozawa, S; Saotome, T; Shintani, Y; Tasaki, K | 1 |
| Chang, YY; Sun, SH; Wang, CM | 1 |
| Amin, AR; Biswas, MH; Hamaguchi, M; Huang, P; Ichigotani, Y; Mon, NN; Oo, ML; Yuan, H | 1 |
| Angulo, E; Canela, EI; Casadó, V; Ferrer, I; Franco, R; Lluis, C; Mallol, J; Viñals, F | 1 |
| DiMattina, AJ; Holland, JA; Johnson, DK; O'Donnell, RW; Stone, RI; Ziegler, LM | 1 |
| Akca, H; Ozes, ON | 1 |
| Ito, S; Ohizumi, Y; Rohra, DK; Saito, SY; Yamakuni, T | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Honda, Y; Kemmochi, S; Miyamoto, N; Oh, H; Ohashi, H; Ojima, T; Sato, Y; Suganami, E; Suzuma, I; Suzuma, K; Takagi, H; Uemura, A; Watanabe, D | 1 |
| Chang, KC; Kang, YJ; Kim, HJ; Ko, YS; Lee, YS; Park, MK; Pyo, HS; Seo, HG; Yun-Choi, HS | 1 |
| Gosmanov, AR; Thomason, DB; Thompson, DB | 1 |
| Armstrong, DD; Burkholder, TJ; Esser, KA; Hornberger, TA; Koh, TJ | 1 |
| Boulton, M; Cai, J; Zhao, B | 1 |
| Delpiano, AM; Hitschfeld, C; Lavandero, S; Lobos, L; Marusic, ET; Michea, L | 1 |
| Leithe, E; Rivedal, E | 1 |
| Clowes, AW; Daum, G; Defawe, O; Kenagy, RD; Millette, E; Rauch, BH | 1 |
| Capra, V; Citro, S; Ravasi, S; Rovati, GE | 1 |
| Cotton, CU; Falin, R; Veizis, IE | 1 |
| Kim, SH; Kim, TS; Oh, SM | 1 |
| Kuan, YH; Lin, CN; Lin, RH; Tsao, LT; Wang, JP | 1 |
| Fukai, N; Hirata, Y; Ozawa, N; Sato, R; Shichiri, M; Sugiyama, T; Yoshimoto, T | 1 |
| Bae, YM; Cho, S; Choi, WH; Kim, B; Kim, J; Lee, CH; Lee, CK; Lee, YR | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Bilecki, W; Przewłocki, R; Urbański, MJ; Wawrzczak-Bargieła, A; Ziółkowska, B | 1 |
| Hong, SS; Hwang, BY; Kang, HS; Kim, YM; Lee, DK; Lee, MK; Ro, JS; Shin, JS; Yang, YJ | 1 |
| Greco, S; Marsigliante, S; Storelli, C | 1 |
| Beales, IL; Ogunwobi, OO | 1 |
| Adrian, TE; Bell, RH; Ding, XZ; Flesche, JB; Robin, TP; Salabat, MR; Talamonti, MS; Ujiki, MB | 1 |
| Hamel, M; Price, CA; Sahmi, M; Silva, JM | 1 |
| Burek, CL; Sharma, RB; Traore, K; Trush, MA | 1 |
| Marsigliante, S; Muscella, A; Romano, S; Storelli, C | 1 |
| Choi, DH; Lee, HJ; Lee, MK; Lee, OK; Paik, KH; Park, JI; Seo, SM; Yang, YJ | 1 |
| Abe, K; Nishiura, T | 1 |
| Sapna, S; Shivakumar, K | 1 |
| Kim, MS; Kim, YJ; Kim, YS; Ryu, JC | 1 |
| Eggo, MC; Susarla, R; Watkinson, JC | 1 |
| Chung, H; Moon, M; Park, S; Seo, S | 1 |
| Bassa, BV; Ganji, SH; Kamanna, VS; Noh, JW; Roh, DD; Shin, MK | 1 |
| Bonanno, A; Ferraro, M; Gjomarkaj, M; Montalbano, AM; Pieper, MP; Pompeo, F; Profita, M; Riccobono, L; Siena, L | 1 |
| Huang, TQ; Lee, JS; Lim, YS; Seo, JS | 1 |
| Ballim, RD; Mowla, S; Prince, S; Teng, H | 1 |
| Baxter, RC; Bolitho, C; Marsh, DJ; Mertens-Walker, I | 1 |
| Kanno, T; Nakano, T; Nishizaki, T; Saito, M; Yaguchi, T; Yasuda, Y | 1 |
| Kim, SY; Park, ES; Youn, DH | 1 |
| Ajiro, Y; Giles, WR; Saegusa, N; Spitzer, KW; Stafforini, DM | 1 |
| Adachi, T; Hara, H; Kamiya, T; Makino, J | 1 |
| Chao, CY; Chen, HW; Li, CC; Lii, CK; Lin, LL; Liu, KL; Lu, CY | 1 |
| Chiu, PH; Sun, SH; Tsao, HK | 1 |
| Bhattacharyya, N; Collins, MT; Dunn, D; Foster, BL; Nociti, FH; Presland, RB; Somerman, MJ; Tran, AB; Wang, L | 1 |
| Gan, W; Han, Y; Li, S; Wang, B; Zhang, A | 1 |
1 review(s) available for pd 98059 and bisindolylmaleimide i
| Article | Year |
|---|---|
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
140 other study(ies) available for pd 98059 and bisindolylmaleimide i
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Stabilization of the B-type natriuretic peptide mRNA in cardiac myocytes by alpha-adrenergic receptor activation: potential roles for protein kinase C and mitogen-activated protein kinase.
Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Colforsin; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Flavonoids; Half-Life; Heart; Indoles; Maleimides; Myocardium; Natriuretic Peptide, Brain; Phenylephrine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Signal Transduction | 1996 |
Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Virulence Factors, Bordetella; Wortmannin | 1996 |
Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells.
Topics: Animals; Anisomycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Endothelins; Enzyme Activation; Flavonoids; Gene Expression Regulation; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lysophospholipids; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; Peptides, Cyclic; Pertussis Toxin; Piperidines; Protein Kinase C; Rats; Receptors, Endothelin; Signal Transduction; Virulence Factors, Bordetella | 1997 |
Roles for protein kinase C and mitogen-activated protein kinase in nicotine-induced secretion from bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chromaffin Cells; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Flavonoids; Indoles; Kinetics; Maleimides; Nicotine; Norepinephrine; Potassium Chloride; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; Indoles; Isomerism; Isoproterenol; Kinetics; Liver; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Taurochenodeoxycholic Acid; Taurocholic Acid; Tetradecanoylphorbol Acetate | 1997 |
Molecular mechanisms for the growth factor action of gastrin.
Topics: Animals; Benzodiazepinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Devazepide; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gastrins; Genes, fos; Hormone Antagonists; Humans; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinase 1; Pancreas; Pertussis Toxin; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection; Virulence Factors, Bordetella | 1997 |
The cyclin-dependent kinase inhibitor p21cip1 mediates the growth inhibitory effect of phorbol esters in human venous endothelial cells.
Topics: Cell Division; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; G1 Phase; Humans; Indoles; Maleimides; Phorbol 12,13-Dibutyrate; Polyenes; Protein Kinase C; RNA, Messenger; Signal Transduction; Sirolimus; Tumor Suppressor Protein p53 | 1997 |
Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by muscarinic receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Atropine; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Cholinergic Agents; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate | 1997 |
Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; CHO Cells; COS Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Maleimides; Mitogen-Activated Protein Kinase Kinases; Muscarinic Agonists; Nerve Growth Factors; PC12 Cells; Phorbol 12,13-Dibutyrate; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic | 1998 |
Regulation of Na+/H+ exchanger gene expression: mitogenic stimulation increases NHE1 promoter activity.
Topics: 3T3 Cells; Animals; Cell Division; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression Regulation; Indoles; Maleimides; Mice; Promoter Regions, Genetic; Protein Kinases; Sodium-Hydrogen Exchangers | 1998 |
Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis.
Topics: Anisomycin; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Protein Kinase C; Tetradecanoylphorbol Acetate | 1998 |
Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway.
Topics: ADP Ribose Transferases; Androstadienes; Botulinum Toxins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Size; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Humans; Hypotonic Solutions; Indoles; Intestines; Iodine Radioisotopes; Maleimides; Osmotic Pressure; Phosphorylation; ras Proteins; Rubidium Radioisotopes; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Modulation of ACh receptor currents by arachidonic acid.
Topics: Acetylcholine; Animals; Arachidonic Acid; Brain Chemistry; Chick Embryo; Cycloheximide; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Indomethacin; Ion Channel Gating; Isoquinolines; Maleimides; Masoprocol; Membrane Potentials; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Receptors, Nicotinic; Sulfonamides; Torpedo; Xenopus | 1998 |
Tyrosine kinase and c-Jun NH2-terminal kinase mediate hypertrophic responses to prostaglandin F2alpha in cultured neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Dinoprost; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique, Indirect; Heart; Heart Ventricles; Hypertrophy; Indoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Maleimides; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle Proteins; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Prostaglandin; Recombinant Fusion Proteins; Signal Transduction; Stress, Physiological; Transfection | 1998 |
Induction of in vitro angiogenesis in the endothelial-derived cell line, EA hy926, by ethanol is mediated through PKC and MAPK.
Topics: Cell Line; Endothelium, Vascular; Enzyme Inhibitors; Ethanol; Flavonoids; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; Neovascularization, Physiologic; Protein Kinase C; Protein Serine-Threonine Kinases; Signal Transduction | 1998 |
Role of p38 MAP kinase in myocardial stress.
Topics: Adenosine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Ischemic Preconditioning, Myocardial; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Tetradecanoylphorbol Acetate | 1998 |
Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Gonadotropin-Releasing Hormone; Indoles; Maleimides; Mice; Pituitary Gland; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-raf; Rats; Receptors, LHRH; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 1999 |
Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase.
Topics: Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Gene Expression Regulation; Glomerular Mesangium; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lactams, Macrocyclic; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Naphthalenes; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; RNA, Messenger; Stress, Mechanical; Time Factors; Transcription Factor AP-1; Transcription, Genetic | 1999 |
Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist.
Topics: Adult; Anemia, Sickle Cell; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; E-Selectin; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes, Abnormal; Flavonoids; HL-60 Cells; Humans; Hypoxia; Indoles; Intercellular Adhesion Molecule-1; Maleimides; Marine Toxins; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; NF-kappa B; Oxazoles; Phospholipid Ethers; Phosphoprotein Phosphatases; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1999 |
Molecular pathways mediating activation by kainate of mitogen-activated protein kinase in oligodendrocyte progenitors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Animals, Newborn; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; GTP-Binding Proteins; Indoles; Kainic Acid; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligodendroglia; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Signal Transduction; Stem Cells; Tritium; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 1999 |
Arachidonic acid potentiates currents through Ca2+-permeable AMPA receptors by interacting with a CaMKII pathway.
Topics: Animals; Arachidonic Acid; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Indoles; Ion Channel Gating; Isoquinolines; Kainic Acid; Maleimides; Oocytes; Patch-Clamp Techniques; Protein Kinase C; Receptors, AMPA; RNA, Messenger; Signal Transduction; Sulfonamides; Xenopus | 1999 |
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis.
Topics: Acetophenones; Animals; Apoptosis; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Isoenzymes; Maleimides; Mice; Mutation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Pyridines; Signal Transduction; Sphingosine; Ultraviolet Rays | 1999 |
The role of mitogen-activated protein kinase and protein kinase C in fibronectin production in human vascular smooth muscle cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibronectins; Flavonoids; Humans; Indoles; Maleimides; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Transforming Growth Factor beta | 1999 |
Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Differentiation; Cell Division; Cell Line; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, ras; GRB2 Adaptor Protein; Indoles; Isoenzymes; Maleimides; Membrane Proteins; Mice; Mice, Transgenic; Phospholipase C gamma; Phosphoproteins; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-sis; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Recombinant Proteins; Signal Transduction; src Homology Domains; Type C Phospholipases | 1999 |
A role for the mitogen-activated protein kinase in mediating the ability of thyrotropin-releasing hormone to stimulate the prolactin promoter.
Topics: Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Mutation; Pituitary Neoplasms; Precipitin Tests; Prolactin; Promoter Regions, Genetic; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Rats; Recombinant Proteins; Signal Transduction; Thyrotropin-Releasing Hormone; Transcription Factors; Tumor Cells, Cultured | 1999 |
MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Maleimides; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Opioid, mu; Recombinant Proteins; Thionucleotides; Transfection; Wortmannin | 1999 |
Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; DNA-Binding Proteins; DNA, Neoplasm; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Immediate-Early Proteins; Indoles; Kinetics; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Transcription Factors; Tumor Cells, Cultured; Valproic Acid | 1999 |
Regulatory effects of HDL on smooth muscle cell prostacyclin release.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Aspirin; Cells, Cultured; Cholesterol, HDL; Cycloheximide; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dactinomycin; Dexamethasone; Enzyme Inhibitors; Epoprostenol; Flavonoids; Gene Expression Regulation, Enzymologic; Indoles; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Synthesis Inhibitors; Rabbits; RNA, Messenger | 1999 |
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.
Topics: Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phorbol Esters; Protein Kinase C; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Rapid signalling by androgen receptor in prostate cancer cells.
Topics: Adenocarcinoma; Androgen Antagonists; Cell Nucleus; Cytoplasm; Dihydrotestosterone; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Indoles; Ligands; Male; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptors, Androgen; Recombinant Fusion Proteins; Testosterone; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured | 1999 |
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.
Topics: 3-O-Methylglucose; Amino Acid Sequence; Animals; Biological Transport; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Glycogen; Imidazoles; In Vitro Techniques; Indoles; Insulin; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphopeptides; Phosphorylation; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate | 2000 |
Roles of mitogen-activated protein kinases and protein kinase C in alpha(1A)-adrenoceptor-mediated stimulation of the sarcolemmal Na(+)-H(+) exchanger.
Topics: Adrenergic alpha-Agonists; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Ventricles; Imidazoles; Indoles; Male; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Myocardium; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Sarcolemma; Sodium-Hydrogen Exchangers; Tetrahydronaphthalenes | 2000 |
Involvement of protein kinase C, p38 MAP kinase and ERK in arachidonic acid-stimulated superoxide production in human neutrophils.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Superoxides | 1999 |
P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Division; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Indoles; Isoenzymes; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Staurosporine; Tumor Cells, Cultured; Uridine Triphosphate; Virulence Factors, Bordetella | 2000 |
Neutrophil beta2-integrin upregulation is blocked by a p38 MAP kinase inhibitor.
Topics: Antigens, CD; CD18 Antigens; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Indoles; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha | 2000 |
Thrombopoietin increases platelet sensitivity to alpha-thrombin via activation of the ERK2-cPLA2 pathway.
Topics: Animals; Blood Platelets; Carbazoles; Cattle; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Humans; Imidazoles; Indoles; Indomethacin; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Processing, Post-Translational; Pyridines; Serotonin; Serum Albumin, Bovine; Thrombin; Thrombopoietin; Thromboxane A2 | 2000 |
Induction of cell cornification and enhanced squamous-cell marker SPRR1 gene expression by phorbol ester are regulated by different signaling pathways in human conducting airway epithelial cells.
Topics: Biomarkers; Cell Size; Cornified Envelope Proline-Rich Proteins; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gene Expression Regulation; Humans; Indoles; Lactams; Maleimides; Membrane Proteins; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinases; Protein Kinase C; Proteins; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Trachea; Transcriptional Activation | 2000 |
Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells.
Topics: 3T3 Cells; Actins; Animals; Antibodies, Monoclonal; Cell Line; Cell Movement; Cytoskeletal Proteins; DNA; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Indoles; Lymphokines; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors; Vinculin | 2000 |
Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.
Topics: Animals; Cell Differentiation; Chelating Agents; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression; Genes, Reporter; GTP-Binding Proteins; Humans; Imidazoles; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Neurons; NF-kappa B; NFATC Transcription Factors; Norepinephrine; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyridines; Rats; Receptors, Adrenergic, alpha-1; Sympathomimetics; Transcription Factors; Transcriptional Activation; Transfection | 2000 |
Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptides stimulate mitogen-activated protein kinase in the pituitary cell line GH4C1 by a 3',5'-cyclic adenosine monophosphate pathway.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adjuvants, Immunologic; Animals; Butadienes; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Inhibitors; Extracellular Space; Flavonoids; Gene Expression; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuropeptides; Nitriles; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland; Prolactin; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor Cross-Talk; RNA, Messenger; Sulfonamides; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 2000 |
Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Insulin; Male; Maleimides; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Time Factors | 2000 |
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
Topics: Alanine; Casein Kinase II; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; GTP Phosphohydrolases; Humans; Immunoblotting; Indoles; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RGS Proteins; Serine; Signal Transduction; Transfection; Tumor Cells, Cultured | 2000 |
Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells.
Topics: Animals; Cinnamates; Drug Synergism; Flavonoids; Glucosides; Indoles; Iridoid Glucosides; Maleimides; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; PC12 Cells; Phosphorylation; Rats | 2000 |
Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury.
Topics: CD55 Antigens; Cells, Cultured; Complement Activation; Complement System Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Feedback; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Indoles; Inflammation; Lymphokines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Receptor, PAR-1; Receptors, Thrombin; Recombinant Proteins; RNA, Messenger; Thrombin; Thrombosis; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils.
Topics: Butadienes; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Nitriles; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst | 2000 |
PKC, p42/p44 MAPK, and p38 MAPK are required for HGF-induced proliferation of H441 cells.
Topics: Adenocarcinoma; Cell Division; Cell Membrane; Cytosol; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Indoles; Isoenzymes; Kinetics; Lung Neoplasms; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tumor Cells, Cultured | 2000 |
Regulation of p38 mitogen-activated protein kinase during NK cell activation.
Topics: Androstadienes; Antibody-Dependent Cell Cytotoxicity; Cytotoxicity, Immunologic; Enzyme Inhibitors; Enzyme Precursors; Flavonoids; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lymphocyte Activation; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Receptors, IgG; src-Family Kinases; Syk Kinase; Wortmannin | 2000 |
Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Blotting, Western; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Osteoblasts; Parathyroid Hormone; Peptides; Phosphorylation; Plasmids; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2001 |
Monocytes are differentially activated through HLA-DR, -DQ, and -DP molecules via mitogen-activated protein kinases.
Topics: Adult; Amino Acid Sequence; Antibodies, Monoclonal; Clone Cells; Coculture Techniques; Emetine; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HLA-D Antigens; HLA-DP Antigens; HLA-DQ Antigens; HLA-DR Antigens; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Monocytes; Monokines; Peptides; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; T-Lymphocyte Subsets | 2001 |
Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate.
Topics: Animals; Cell Division; Cell Line; Cell Membrane; Cyclin D1; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Flavonoids; Indoles; Isoenzymes; Kinetics; Maleimides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate; Vanadates | 2001 |
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction | 2001 |
Characterization of the 5'-flanking region of the rat TIS11 gene.
Topics: Animals; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Immediate-Early; Genes, Reporter; Immediate-Early Proteins; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinase Kinases; PC12 Cells; Promoter Regions, Genetic; Protein Kinase C; Rats; Sequence Deletion; Tetradecanoylphorbol Acetate; Tristetraprolin | 2000 |
Glycated serum albumin-induced vascular smooth muscle cell proliferation through activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by protein kinase C.
Topics: Animals; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Indoles; Isoenzymes; Luciferases; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Recombinant Fusion Proteins; Serum Albumin; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2001 |
Human uterine myometrial smooth muscle cell proliferation and vascular endothelial growth-factor production in response to platelet-derived growth factor.
Topics: Adult; Analysis of Variance; Biological Assay; Blotting, Western; Cell Division; Cells, Cultured; Endothelial Growth Factors; Enzyme Inhibitors; Extracellular Matrix Proteins; Female; Flavonoids; Humans; Indoles; Lymphokines; Maleimides; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth; Myometrium; Platelet-Derived Growth Factor; Protein Isoforms; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thymidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator.
Topics: Androstadienes; Antineoplastic Agents; Biomarkers; Cell Differentiation; Diterpenes; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Interferon-gamma; Leukemia, Myeloid; Lipopolysaccharide Receptors; Maleimides; Monocytes; Naphthalenes; Plant Growth Regulators; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells; Virulence Factors, Bordetella; Wortmannin | 2001 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade.
Topics: Animals; Arachidonic Acid; Cation Transport Proteins; Cells, Cultured; Cholecystokinin; Colforsin; DNA-Binding Proteins; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Flavonoids; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Membrane Potentials; Membrane Transport Proteins; Patch-Clamp Techniques; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Protein Kinases; Rats; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Trans-Activators; Transcriptional Regulator ERG; Tyrphostins; Vasoactive Intestinal Peptide | 2001 |
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
Topics: Androstadienes; Benzoquinones; Blotting, Western; Cell Division; Cells, Cultured; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Indoles; Lactams, Macrocyclic; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Isoforms; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rifabutin; Thrombin; Time Factors; Trachea; Transfection; Virulence Factors, Bordetella; Wortmannin | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.
Topics: Adenoviridae; Blotting, Northern; Blotting, Western; Carcinogens; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Primers; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Naphthol AS D Esterase; Prostatic Neoplasms; Protein Kinase C; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2001 |
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoquinones; Cell Differentiation; Chromones; Cyclic AMP; Enzyme Inhibitors; Flavonoids; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Indoles; Isoproterenol; Isoquinolines; Lactams, Macrocyclic; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sirolimus; Sulfonamides; Tumor Cells, Cultured; Wortmannin | 2001 |
Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzophenanthridines; Calcitriol; Capsaicin; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Maleimides; Phenanthridines; Protein Kinase C; Signal Transduction; Tretinoin | 2001 |
Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway.
Topics: Acetylcysteine; Androstadienes; Animals; Cyclic N-Oxides; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Indoles; Isoquinolines; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neurites; Neuroprotective Agents; Nitrogen Oxides; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Protein Kinase C; ras Proteins; Rats; Recombinant Proteins; Signal Transduction; Sulfonamides; Transfection; Wortmannin | 2001 |
The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Membrane; Chlorocebus aethiops; COS Cells; CSK Tyrosine-Protein Kinase; Enzyme Induction; Enzyme Inhibitors; Flavonoids; G1 Phase; Genes, src; Humans; Indoles; Isoenzymes; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Protein-Tyrosine Kinases; Receptors, Somatostatin; S Phase; Signal Transduction; Somatostatin; src-Family Kinases; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells.
Topics: Androstadienes; Butadienes; Chromones; Enzyme Inhibitors; Female; Fibronectins; Flavonoids; Humans; Indoles; Maleimides; MAP Kinase Kinase 1; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neoplasm Invasiveness; Nitriles; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured; Wortmannin | 2000 |
Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells.
Topics: Animals; Antifungal Agents; Antioxidants; Apoptosis; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyridines; ras Proteins; Rats; Reactive Oxygen Species; Thiones; Time Factors; Transfection; Zinc | 2001 |
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Flow Velocity; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cardiovascular Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dogs; Enzyme Inhibitors; Flavonoids; Hemodynamics; Imidazoles; Indoles; Isoquinolines; Maleimides; Milrinone; Mitogen-Activated Protein Kinases; Myocardial Infarction; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase Inhibitors; Protein Kinase C; Pyridines; Pyridones; Sulfonamides; Ventricular Fibrillation | 2001 |
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Topics: Androstadienes; Benzylamines; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Epithelial Cells; Flavonoids; Genistein; Humans; Indoles; Interleukin-8; Isoquinolines; Lung; Maleimides; Okadaic Acid; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Sulfonamides; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2001 |
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin | 2001 |
Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells.
Topics: Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Inhibitory Concentration 50; Interphase; Maleimides; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Naphthalenes; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Staurosporine; Transcription Factors; Tretinoin | 2001 |
Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Membrane; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; fas Receptor; Flavonoids; HL-60 Cells; Humans; Indoles; Isoenzymes; Lamin Type B; Lamins; Maleimides; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Retinoblastoma Protein; Thapsigargin; Tocopherols; U937 Cells; Vitamin E | 2001 |
TNF-alpha enhances intracellular glucocorticoid availability.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Cells, Cultured; Colforsin; Corticosterone; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Glucose; Hydroxysteroid Dehydrogenases; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Simultaneous signalling through c-mpl, c-kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC and MAPK pathways.
Topics: Cell Cycle Proteins; Cell Differentiation; Cell Division; Chromones; Drug Synergism; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Heat-Shock Proteins; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Megakaryocytes; Microfilament Proteins; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptors, CXCR4; Receptors, Cytokine; Receptors, Thrombopoietin; Schizosaccharomyces pombe Proteins; Signal Transduction; Stem Cell Factor; Stem Cells; Stimulation, Chemical; Thrombopoietin | 2001 |
Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein.
Topics: Adipokines; Animals; Apelin; Apelin Receptors; Carrier Proteins; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endothelium; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Dominant; GTP-Binding Proteins; Immunoblotting; Indoles; Intercellular Signaling Peptides and Proteins; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monomeric GTP-Binding Proteins; Mutation; Peptide Fragments; Pertussis Toxin; Phosphorylation; Plasmids; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Receptors, Cell Surface; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Time Factors; Transfection; Type C Phospholipases; Virulence Factors, Bordetella | 2002 |
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins | 2002 |
Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.
Topics: Adrenergic alpha-Agonists; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart; Imidazoles; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Ribosomal Protein S6 Kinases, 90-kDa | 2002 |
Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Astrocytes; Brain; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Fetus; Flavonoids; Genistein; Glial Fibrillary Acidic Protein; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Phorbol 12,13-Dibutyrate; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases | 2002 |
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin | 2002 |
Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway.
Topics: Antigens, Differentiation; Cell Membrane; Cell Transformation, Neoplastic; Choriocarcinoma; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Immunoenzyme Techniques; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neprilysin; Phorbol Esters; Phosphorylation; Protein Kinase C; Time Factors; Tumor Cells, Cultured | 2002 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline.
Topics: Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indans; Indoles; Maleimides; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monoamine Oxidase Inhibitors; Naphthalenes; Neuroprotective Agents; PC12 Cells; Protein Kinase C; Rats; Stereoisomerism; Tumor Cells, Cultured | 2002 |
Regulation of ionomycin-mediated granule release from rat basophil leukemia cells.
Topics: Animals; Basophils; Butadienes; Cell Degranulation; Drug Synergism; Enzyme Inhibitors; Flavonoids; Indoles; Ionomycin; Ionophores; Leukemia, Myeloid; Maleimides; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Tumor Cells, Cultured | 2002 |
[G-protein-coupled muscarinic acetylcholine receptor activation up-regulates Bcl-2 and phospho-bad via Ras-ERK-1/2 signaling pathway].
Topics: Atropine; bcl-Associated Death Protein; Carbachol; Carrier Proteins; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; Humans; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyrimidines; ras Proteins; Receptors, Muscarinic; Signal Transduction; Tumor Cells, Cultured; Up-Regulation | 2003 |
Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Antibodies, Monoclonal; Antigens, CD; Carrier Proteins; Cytokine Receptor gp130; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Human Growth Hormone; Humans; Immunoblotting; Indoles; Janus Kinase 2; Maleimides; MAP Kinase Kinase 1; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, ErbB-2; Recombinant Fusion Proteins; Signal Transduction; Transfection; Ubiquitin-Protein Ligases | 2003 |
Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells.
Topics: Animals; Aorta; Cells, Cultured; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Imidazoles; Imines; Indoles; Interleukin-6; Isoquinolines; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Protein Kinase C; Pyridines; Rats; Sulfonamides; Urocortins | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Blotting, Western; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Flavonoids; Humans; Imidazoles; Indoles; Interleukin-1; Kinetics; Maleimides; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; NF-kappa B; Pancreas; Proline; Pyridines; Thiocarbamates; Tumor Necrosis Factor-alpha | 2003 |
Activation of P2X7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Astrocytes; Blotting, Northern; Blotting, Western; Brain; Carbazoles; Cell Line; Dose-Response Relationship, Drug; Flavonoids; Gene Expression; Indoles; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation.
Topics: Animals; Antigens, Differentiation; BALB 3T3 Cells; Cell Division; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Glycoproteins; Immunoblotting; Indoles; Interleukin-1; Maleimides; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Neural Cell Adhesion Molecule L1; Phospholipase C gamma; Phosphorylation; Plasmids; Precipitin Tests; Protein Kinase C; Pyrrolidinones; Receptors, Immunologic; Signal Transduction; Tetrazolium Salts; Thiazoles; Thymidine; Time Factors; Type C Phospholipases | 2003 |
A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Blotting, Western; Brain; Case-Control Studies; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Flavonoids; Humans; Immunohistochemistry; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Phosphorylation; Receptor, Adenosine A1; Receptors, Adenosine A2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; tau Proteins; Time Factors; Translocation, Genetic; Tubulin; Xanthines | 2003 |
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.
Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins | 2003 |
Epidermal growth factor suppresses interferon-induced accumulation of p53 and p21 by using protein kinase C.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Indoles; Interferon-alpha; Interferon-gamma; Interferons; Maleimides; Morpholines; Protein Kinase C; Tumor Suppressor Protein p53 | 2003 |
Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.
Topics: Animals; Aorta, Thoracic; Bridged-Ring Compounds; Butadienes; Drug Synergism; Estrenes; Flavonoids; Hydrogen-Ion Concentration; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nitriles; Norbornanes; Phosphatidate Phosphatase; Phosphatidylinositol Diacylglycerol-Lyase; Potassium Chloride; Propranolol; Protein Kinase C; Pyrrolidinones; Rats; Rats, Inbred SHR; Thiocarbamates; Thiones; Type C Phospholipases; Tyrphostins | 2004 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.
Topics: Adenoviridae; Angiopoietin-2; Animals; Blotting, Northern; Blotting, Western; Butadienes; Carbazoles; Cattle; Cell Division; Disease Models, Animal; DNA; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Humans; Hypoxia; Indoles; Maleimides; Mice; Models, Biological; Neovascularization, Pathologic; Neuropilin-1; Nitriles; Phosphorylation; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Reperfusion Injury; Retina; RNA, Messenger; Staurosporine; Time Factors; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A | 2004 |
Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions.
Topics: Animals; Blotting, Northern; Curcumin; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Flavonoids; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Phosphorylation; Pulmonary Artery; Pyridines; RNA, Messenger; Sheep; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tetrahydroisoquinolines; Tumor Necrosis Factor-alpha | 2004 |
Regulation of Na(+)-K(+)-2Cl- cotransporter activity in rat skeletal muscle and intestinal epithelial cells.
Topics: Animals; Bumetanide; Butadienes; Cell Line; Chromones; Colforsin; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gastrointestinal Tract; Indoles; Isoproterenol; Isoquinolines; Maleimides; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Skeletal; Nitriles; Potassium; Rats; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Sulfonamides | 2003 |
Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction.
Topics: Animals; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Gadolinium; Genistein; Indoles; Maleimides; Mechanoreceptors; Mechanotransduction, Cellular; Mice; Morpholines; Myoblasts, Skeletal; Paracrine Communication; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Stress, Mechanical; Tensile Strength | 2005 |
Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glucose; Hyperglycemia; Immunoprecipitation; Indoles; Maleimides; MAP Kinase Signaling System; Microcirculation; Neovascularization, Pathologic; Placenta Growth Factor; Pregnancy Proteins; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.
Topics: Aldosterone; Androstadienes; Animals; Blotting, Western; Calcium; Chromones; Enzyme Inhibitors; Eplerenone; Flavonoids; Hydrogen-Ion Concentration; Indoles; Male; Maleimides; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Morpholines; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Time Factors; Vasoconstriction; Wortmannin | 2005 |
Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells.
Topics: Animals; Blotting, Western; Carcinogens; Cell Communication; Cell Line; Cell Line, Tumor; Connexin 43; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fluorescent Dyes; Gap Junctions; Image Processing, Computer-Assisted; Indoles; Isoquinolines; Liver; Maleimides; MAP Kinase Signaling System; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.
Topics: Aorta, Abdominal; Becaplermin; Cell Division; Cell Movement; Cells, Cultured; Chromones; DNA Replication; Enzyme Activation; Fibroblast Growth Factor 2; Flavonoids; Heparin; Humans; Indoles; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Recombinant Proteins; RNA, Small Interfering; Tyrphostins | 2005 |
Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Bronchi; Cells, Cultured; DNA; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Indoles; Maleimides; Muscle, Smooth; Pyrazoles; Pyrimidines; ras Proteins; Receptors, Thromboxane; Signal Transduction | 2005 |
A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption.
Topics: Adenosine Triphosphate; Amiloride; Animals; Biological Transport; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hydroquinones; Indoles; Kidney Tubules, Collecting; Maleimides; Mice; Phorbol Esters; Phosphorylation; Protein Kinase C; Sodium | 2005 |
Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstadienes; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Cell Differentiation; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HL-60 Cells; Humans; Indoles; Lactones; Maleimides; Models, Biological; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Wortmannin | 2005 |
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.
Topics: Animals; Butadienes; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Immunoblotting; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2005 |
Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells.
Topics: Aldosterone; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Endothelial Cells; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Induction; Flavonoids; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Peptides, Cyclic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Endothelin; RNA, Messenger; Sulfonamides | 2004 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hypertension; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasodilator Agents; Verapamil | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors.
Topics: AIDS-Related Complex; Analysis of Variance; Animals; Blotting, Western; Cell Line, Tumor; Corpus Striatum; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Flavonoids; Gene Expression; Gene Expression Regulation; Indoles; Male; Maleimides; Mice; Mice, Inbred C57BL; Morphine; Narcotics; Neuroblastoma; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Time Factors | 2005 |
Induction of neurite outgrowth by (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol from PC12 cells.
Topics: Animals; Araliaceae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Indoles; Lignin; Maleimides; MAP Kinase Signaling System; Medicine, East Asian Traditional; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factor; Neurites; PC12 Cells; Plant Bark; Plant Stems; Plants, Medicinal; Protein Kinase C; Rats | 2005 |
Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin.
Topics: Analysis of Variance; Biological Transport; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Chromones; Cytosol; Dose-Response Relationship, Drug; Estrenes; Female; Flavonoids; Humans; Immunoblotting; Indoles; Kallidin; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Protein Kinase C-epsilon; Pyrrolidinones; Stimulation, Chemical; Tetrahydroisoquinolines | 2006 |
Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.
Topics: Adiponectin; Cell Proliferation; Chemokine CCL2; Cytokines; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; HT29 Cells; Humans; Imidazoles; Indoles; Interleukin-1; Interleukin-8; Intestinal Mucosa; Isoquinolines; Maleimides; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sulfonamides; Sulfones | 2006 |
On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells.
Topics: Cell Division; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin B; Cyclin B1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Flavonoids; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate | 2006 |
Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro.
Topics: Animals; Aromatase; Blotting, Northern; Cattle; Cells, Cultured; Chromones; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Follicle Stimulating Hormone; Follicular Phase; Granulosa Cells; Indoles; Insulin; Isoquinolines; Maleimides; MAP Kinase Signaling System; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; RNA, Messenger; Sulfonamides | 2006 |
Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line.
Topics: Blotting, Western; Butadienes; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Indoles; Intercellular Adhesion Molecule-1; Leukemia, Myeloid; Maleimides; Mitogen-Activated Protein Kinases; Models, Biological; NF-kappa B; Nitriles; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Sulfones; Tetradecanoylphorbol Acetate | 2007 |
Angiotensin II does not stimulate proliferation of rat thyroid PC Cl3 cell line.
Topics: Angiotensin II; Animals; Cell Line; Cell Proliferation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Indoles; Insulin; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Rats; RNA Interference; Signal Transduction; Thyroid Gland | 2006 |
Effects of (+)-eudesmin from the stem bark of magnolia kobus DC. var. borealis Sarg. on neurite outgrowth in PC12 cells.
Topics: Animals; Flavonoids; Furans; Humans; Indoles; Isoquinolines; Lignans; Magnetic Resonance Spectroscopy; Magnolia; Maleimides; Neurites; PC12 Cells; Plant Bark; Protein Kinase Inhibitors; Rats; Sulfonamides | 2006 |
Alpha1-adrenergic receptor stimulation induces the expression of receptor activator of nuclear factor kappaB ligand gene via protein kinase C and extracellular signal-regulated kinase pathways in MC3T3-E1 osteoblast-like cells.
Topics: 3T3 Cells; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Indoles; Maleimides; Mice; Osteoblasts; Phenylephrine; Prazosin; Propranolol; Protein Kinase C; Receptor Activator of Nuclear Factor-kappa B; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Yohimbine | 2007 |
Substance P enhances soluble ICAM-1 release from adult rat cardiac fibroblasts by a p42/44 MAPK- and PKC-mediated mechanism.
Topics: Animals; Cells, Cultured; Fibroblasts; Flavonoids; Indoles; Intercellular Adhesion Molecule-1; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P | 2007 |
The inhibitory mechanism of methylmercury on differentiation of human neuroblastoma cells.
Topics: Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Flow Cytometry; Humans; Indoles; Interphase; Maleimides; Methylmercury Compounds; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroblastoma; Phosphorylation; Protein Kinase C-alpha; Time Factors; Tretinoin | 2007 |
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function.
Topics: Adenylyl Cyclases; Aprotinin; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activators; Epidermal Growth Factor; Fibroblast Growth Factors; Flavonoids; Humans; Indoles; Insulin; Iodine; Iodine Radioisotopes; Maleimides; Mesylates; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Plasminogen Inactivators; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Pyrroles; RNA, Messenger; Serine Proteinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2007 |
IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
Topics: Androstadienes; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biological Transport; Cell Line; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Immunohistochemistry; Indoles; Insulin-Like Growth Factor I; Isoquinolines; Male; Maleimides; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neurons; Oligonucleotides, Antisense; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Recombinant Proteins; Stroke; Sulfonamides; Wortmannin | 2007 |
Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.
Topics: Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Indoles; Lysophosphatidylcholines; Maleimides; MAP Kinase Signaling System; Mesangial Cells; Protein Kinase C; Quinazolines; src-Family Kinases; Tyrphostins | 2007 |
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.
Topics: Acetylcholine; Bronchi; Cell Line, Transformed; Chemotaxis, Leukocyte; Epithelial Cells; Flavonoids; Gallamine Triethiodide; Humans; Indoles; Interleukin-8; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscarinic Antagonists; Neutrophils; NF-kappa B; Nitriles; Piperidines; Pirenzepine; Protein Kinase C; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives; Sulfones; Tiotropium Bromide | 2008 |
Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression.
Topics: Animals; Carbazoles; Cell Line; Flavonoids; HSP70 Heat-Shock Proteins; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Signaling System; Mice; NFATC Transcription Factors; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Transport; Saline Solution, Hypertonic; Signal Transduction; Sulfonamides | 2008 |
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene.
Topics: Binding Sites; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; Histones; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Serine; Signal Transduction; Sp1 Transcription Factor; T-Box Domain Proteins; Tetradecanoylphorbol Acetate | 2009 |
Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}.
Topics: Acetophenones; Benzopyrans; Calcium; Calcium Channels, L-Type; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dantrolene; Egtazic Acid; Female; Flavonoids; Follicle Stimulating Hormone; Humans; Indoles; Luteinizing Hormone; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; Protein Kinase C-delta; RNA, Small Interfering; Signal Transduction; Verapamil | 2010 |
Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Cell Survival; Colonic Neoplasms; Flavonoids; Humans; Indoles; Maleimides; Mitogen-Activated Protein Kinase 3; Protein Kinase C; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2X; Receptors, Purinergic P2Y | 2010 |
NMDA receptor, PKC and ERK prevent fos expression induced by the activation of group I metabotropic glutamate receptors in the spinal trigeminal subnucleus oralis.
Topics: Animals; Benzoates; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Glycine; Indoles; Male; Maleimides; Neurons; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Trigeminal Nucleus, Spinal | 2010 |
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
Topics: Acidosis; Alkalosis; Animals; Azepines; Benzophenanthridines; Dose-Response Relationship, Drug; Flavonoids; Guanidines; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; Indoles; Ion Transport; Maleimides; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase Inhibitors; Receptors, G-Protein-Coupled; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Sulfones; Time Factors; Triazoles | 2011 |
TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS.
Topics: Butadienes; Cell Differentiation; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Indoles; Macrophages; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NADPH Oxidases; Nitriles; Protein Kinase C; Reactive Oxygen Species; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2012 |
Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Cell Survival; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Heme Oxygenase-1; Humans; Indoles; Maleimides; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2013 |
PKC-dependent ERK phosphorylation is essential for P2X7 receptor-mediated neuronal differentiation of neural progenitor cells.
Topics: Adenosine Triphosphate; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cerebral Ventricles; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; HEK293 Cells; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Neural Stem Cells; Protein Kinase C; Protein Processing, Post-Translational; Purinergic P2X Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X7 | 2013 |
Vitamin D represses dentin matrix protein 1 in cementoblasts and osteocytes.
Topics: Animals; Calcitriol; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dental Cementum; Dose-Response Relationship, Drug; Down-Regulation; Estrenes; Extracellular Matrix Proteins; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Flavonoids; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Indoles; Maleimides; MAP Kinase Signaling System; Mice; Osteocytes; Protein Kinase C; Pyrrolidinones; Receptors, Calcitriol; Type C Phospholipases; Vitamins; Vorinostat | 2014 |
Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways.
Topics: Aldosterone; Animals; Benzofurans; Calcium; Cell Communication; Cell Line; Cell Proliferation; Chromones; Connexin 43; Flavonoids; Fluorescent Dyes; Gap Junctions; Gene Expression Regulation; Indoles; Isoquinolines; Maleimides; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone | 2015 |