pd 98059 and bay 11-7082

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

Topics: Animals; Anti-Inflammatory Agents; Diarylheptanoids; Janus Kinase 2; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Sepsis; STAT3 Transcription Factor

Topics: Androstadienes; Animals; Animals, Newborn; Carbazoles; Chickens; Estrenes; Flavonoids; Indoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Neutrophils; Nitriles; Pyrrolidinones; Receptors, Cell Surface; Respiratory Burst; Signal Transduction; Sulfones; Teichoic Acids; Toll-Like Receptor 2; Toll-Like Receptors; Wortmannin

Topics: 2-Methoxyestradiol; Apoptosis; Arabidopsis Proteins; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Chromones; Death Domain Receptor Signaling Adaptor Proteins; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Estradiol; fas Receptor; Fatty Acid Desaturases; Flavonoids; Genes, Dominant; Humans; I-kappa B Proteins; Intracellular Signaling Peptides and Proteins; Luciferases; Male; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Organic Chemicals; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor; Signal Transduction; Sulfones; Tumor Cells, Cultured

Topics: Astrocytes; Blotting, Western; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Microglia; Nerve Growth Factors; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Sulfones; Trimethyltin Compounds; Tumor Necrosis Factor-alpha

Topics: Bacterial Outer Membrane Proteins; Caco-2 Cells; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Escherichia coli; Flavonoids; Humans; Imidazoles; Luminescent Measurements; Mitogen-Activated Protein Kinases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Nitrites; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfones

Topics: Adiponectin; Cell Proliferation; Chemokine CCL2; Cytokines; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; HT29 Cells; Humans; Imidazoles; Indoles; Interleukin-1; Interleukin-8; Intestinal Mucosa; Isoquinolines; Maleimides; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sulfonamides; Sulfones

Topics: Animals; Blotting, Western; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-10; Monocytes; Morpholines; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Receptors, Formyl Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Amyloid A Protein; Sulfones; Tumor Necrosis Factor-alpha

Topics: CD11b Antigen; Cell Line; Cytokines; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Profiling; Humans; I-kappa B Proteins; Inflammation; Monocytes; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Sulfides; Sulfones; Time Factors; Up-Regulation

Topics: Actins; Adhesins, Bacterial; Bacterial Outer Membrane Proteins; Caco-2 Cells; Cell Adhesion Molecules; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Flavonoids; Humans; Junctional Adhesion Molecules; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitriles; Porins; Receptors, Virus; Sulfones; Tight Junctions

Topics: Active Transport, Cell Nucleus; Algorithms; Anthraquinones; Cell Line; Cell Nucleus; Computer Simulation; Cytoplasm; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fatty Acids, Unsaturated; Flavonoids; Fluorescent Antibody Technique, Indirect; HeLa Cells; Humans; I-kappa B Proteins; Inhibitory Concentration 50; Kidney; Models, Biological; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction; Sulfones; Time Factors

Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hydrocarbons, Brominated; Interleukin-6; Macrophage Activation; Mice; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha

Topics: Acetylcholine; Bronchi; Cell Line, Transformed; Chemotaxis, Leukocyte; Epithelial Cells; Flavonoids; Gallamine Triethiodide; Humans; Indoles; Interleukin-8; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscarinic Antagonists; Neutrophils; NF-kappa B; Nitriles; Piperidines; Pirenzepine; Protein Kinase C; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives; Sulfones; Tiotropium Bromide

Topics: Autocrine Communication; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Coculture Techniques; Cytokine Receptor gp130; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Fimbriae Proteins; Fimbriae, Bacterial; Flavonoids; Humans; Interleukin-6; Mutation; NF-kappa B; Nitriles; Pili, Sex; Porphyromonas gingivalis; Sulfones; Umbilical Veins

Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Arecoline; Cheek; Cholinergic Agonists; Connective Tissue Growth Factor; Curcumin; Endothelial Cells; Epithelial Cells; Fibroblasts; Flavonoids; Humans; Imidazoles; Mouth Mucosa; Nitriles; Oral Submucous Fibrosis; Pyridines; Sulfones

Topics: Caco-2 Cells; Chemokine CXCL10; Dexamethasone; Epithelial Cells; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glucocorticoids; HT29 Cells; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Intestines; NF-kappa B; Nitriles; Pyridines; Pyrrolidines; Receptors, Glucocorticoid; RNA, Messenger; Sulfones; Thiocarbamates

Topics: Antithrombins; Cells, Cultured; Chromones; Endothelium, Vascular; Factor Xa; Flavonoids; Hirudins; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Sulfones; Thrombin; Thromboplastin; Up-Regulation

Topics: Antigen-Antibody Complex; Cell Survival; Cytokines; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HMGB1 Protein; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Lupus Vasculitis, Central Nervous System; Monocytes; Nitriles; Pyridines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Signal Transduction; Sulfones; Transcription Factor RelA; Transendothelial and Transepithelial Migration; U937 Cells; Up-Regulation; Vascular Cell Adhesion Molecule-1

Topics: C-Reactive Protein; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; NF-kappa B p50 Subunit; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Signal Transduction; Sulfones

Topics: Active Transport, Cell Nucleus; Butadienes; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Estrenes; Flavonoids; Furans; Gene Expression Regulation; Hormone Antagonists; Humans; Mifepristone; NF-kappa B; Nitriles; Progesterone; Promoter Regions, Genetic; Protein Binding; Receptors, Progesterone; Sulfones; Tumor Suppressor Protein p53

Topics: Animals; Antiprotozoal Agents; Cell Differentiation; Cell Survival; Flavonoids; Humans; Nitriles; Protein Kinase Inhibitors; Protein Kinases; Pyrimethamine; Signal Transduction; Sulfones; Toxoplasma; Toxoplasmosis; Tyrphostins