pd 98059 has been researched along with arachidonic acid in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (42.00) | 18.2507 |
| 2000's | 26 (52.00) | 29.6817 |
| 2010's | 3 (6.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fitzpatrick, FA; Lepley, RA | 1 |
| Pyne, NJ; Pyne, S; Tolan, D | 1 |
| Abu-Ghazaleh, R; Cospedal, R; Houliston, RA; Martin, J; Wheeler-Jones, C; Zachary, I | 1 |
| Herrera, R | 1 |
| Matsuoka, T; Nishizaki, T; Nomura, T; Sumikawa, K | 1 |
| Israels, SJ; McNicol, A; Philpott, CL; Shibou, TS | 1 |
| Börsch-Haubold, AG; Pasquet, S; Watson, SP | 1 |
| Hayashi, K; Kubo, M; Kutsuwa, M; Kyo, R; Nakahata, N; Ohizumi, Y | 1 |
| Balboa, MA; Balsinde, J; Carman, GM; Dennis, EA; Dillon, DA | 1 |
| Barbour, SE; Carter, AD; Kapur, A; Rabah, D; Wong, C | 1 |
| Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH | 1 |
| Enikolopov, G; Matsuoka, T; Nishizaki, T; Nomura, T; Sumikawa, K | 1 |
| Kelly, A; Lynch, MA; Maguire, C; McGahon, B | 1 |
| Perkinton, MS; Sihra, TS; Williams, RJ | 1 |
| Chen, BC; Lin, LL; Lin, WW | 1 |
| Banfi, C; Battaini, F; Cattaneo, MG; Galli, C; Mussoni, L; Risé, P; Tremoli, E; Vicentini, L | 1 |
| Abdel-Latif, AA; Husain, S | 1 |
| Castegnaro, M; Garren, L; Miller, DJ; Pfohl-Leszkowicz, A; Pinelli, E; Pipy, B; Poux, N | 1 |
| Choy, PC; Geiger, JD; Golfman, LS; Haughey, NJ; Jiang, JY; Lee, D; Wong, JT | 1 |
| Caput, D; Escoubet, L; Ferrara, P; Pipy, B; Quartulli, F; Rey, A; Sozzani, P | 1 |
| Balboa, MA; Balsinde, J; Dennis, EA | 1 |
| Bilney, A; Ferrante, A; Hii, CS; Huang, ZH; Murray, AW; Rathjen, DA; Stacey, K | 1 |
| Barnes, PJ; Cambridge, L; Hart, LA; Lindsay, MA; Newton, R; Stevens, DA | 1 |
| Atsumi, G; Chilton, FH; Fonteh, AN; LaPorte, T | 1 |
| Lin, WW; Wen, HC | 1 |
| Huwiler, A; Johansen, B; Pfeilschifter, J; Skarstad, A | 1 |
| Gonzalez, A; Schmid, A; Schulz, I; Siegel, G; Sternfeld, L | 1 |
| Bauer, CK; Schledermann, W; Schwarz, JR; Wulfsen, I | 1 |
| Linch, DC; Mollapour, E; Roberts, PJ | 1 |
| Chang, LC; Wang, JP | 1 |
| Houliston, RA; Wheeler-Jones, CP | 1 |
| Akiba, S; Hayama, M; Inoue, R; Sato, T | 1 |
| Freeman, EJ; Silfani, TN | 1 |
| Dosoretz, A; Holland, JF; Kirschenbaum, A; Levine, AC; Liu, XH; Lu, M; Yao, S | 1 |
| Cederbaum, AI; Wu, D | 1 |
| Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH | 1 |
| Berenbaum, F; Bereziat, G; Humbert, L; Thirion, S | 1 |
| Aimond, F; Donadille, D; Fauconnier, J; Vassort, G | 1 |
| Lisinicchia, JG; Watts, VJ | 1 |
| Han, C; Shelhamer, JH; Wu, T | 1 |
| Achakzai, MI; Ali, R; Connor, JD; Fecto, FA; Gilani, AU; Rasheed, H; Saeed, SA | 1 |
| de Boland, AR; Gentili, C; Morelli, S | 2 |
| Cantoni, O; Cerioni, L; Guidarelli, A; Tommasini, I | 1 |
| Alberghina, M; Anfuso, CD; Giurdanella, G; Lupo, G; Marchetti, B; Nicotra, A; Ragusa, N; Tirolo, C | 1 |
| Slomiany, A; Slomiany, BL | 1 |
| Han, HJ; Lee, MY; Lee, SH | 1 |
| Funae, Y; Imaoka, S; Oguro, A; Sakamoto, K | 1 |
| Drevenšek, G; Ljuca, F; Zerem, E | 1 |
| Cubero, FJ; Nieto, N | 1 |
50 other study(ies) available for pd 98059 and arachidonic acid
| Article | Year |
|---|---|
Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Base Sequence; Biological Transport; Calcimycin; Cell Differentiation; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocytes; HL-60 Cells; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Nuclear Envelope; Protein Kinase Inhibitors; Recombinant Proteins | 1996 |
Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cytosol; Dinoprostone; Down-Regulation; Drug Interactions; Flavonoids; Guinea Pigs; Indoles; Indomethacin; Maleimides; Muscle, Smooth; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Trachea | 1997 |
Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytosol; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Flavonoids; Humans; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Weight; Phospholipases A; Phospholipases A2; Protein Kinase Inhibitors; Signal Transduction; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway.
Topics: Actins; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Adhesion; Cell Movement; Collagen; Desmosomes; Enzyme Inhibitors; Extracellular Matrix Proteins; Flavonoids; Hepatocyte Growth Factor; HT29 Cells; Humans; Laminin; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Modulation of ACh receptor currents by arachidonic acid.
Topics: Acetylcholine; Animals; Arachidonic Acid; Brain Chemistry; Chick Embryo; Cycloheximide; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Indomethacin; Ion Channel Gating; Isoquinolines; Maleimides; Masoprocol; Membrane Potentials; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Receptors, Nicotinic; Sulfonamides; Torpedo; Xenopus | 1998 |
Effects of the mitogen-activated protein (MAP) kinase kinase inhibitor 2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one (PD98059) on human platelet activation.
Topics: Arachidonic Acid; Blood Platelets; Enzyme Inhibitors; Flavonoids; Humans; In Vitro Techniques; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Platelet Activation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Thromboxane A2 | 1998 |
Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Isoenzymes; Membrane Proteins; Platelet Activation; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Pyridines; Thromboxane A2; Thromboxane-A Synthase | 1998 |
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavanones; Flavonoids; Glioma; Ionophores; Molecular Sequence Data; Phosphorylation; Prostaglandin Antagonists; Rats; Tumor Cells, Cultured | 1998 |
Proinflammatory macrophage-activating properties of the novel phospholipid diacylglycerol pyrophosphate.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycerophospholipids; Inflammation Mediators; Macrophage Activation; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C | 1999 |
Mature macrophage cell lines exhibit variable responses to LPS.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophage Activation; Macrophage-1 Antigen; Macrophages; Mice; Phospholipases A; Phospholipases A2; Phospholipids; Signal Transduction; Tetradecanoylphorbol Acetate; Tritium | 1998 |
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Arachidonic acid potentiates currents through Ca2+-permeable AMPA receptors by interacting with a CaMKII pathway.
Topics: Animals; Arachidonic Acid; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Indoles; Ion Channel Gating; Isoquinolines; Kainic Acid; Maleimides; Oocytes; Patch-Clamp Techniques; Protein Kinase C; Receptors, AMPA; RNA, Messenger; Signal Transduction; Sulfonamides; Xenopus | 1999 |
Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinase 1; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1999 |
Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Arachidonic Acid; Benzodiazepines; Benzothiadiazines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Genistein; GTP-Binding Proteins; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, AMPA; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1999 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells.
Topics: Antioxidants; Arachidonic Acid; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; Cholesterol, VLDL; Endothelium, Vascular; Enzyme Inhibitors; Estrenes; Fibrinolysis; Flavonoids; Gallic Acid; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase C; Pyrrolidinones; Signal Transduction; Thapsigargin; Tritium; Tumor Cells, Cultured; Tyrosine | 1999 |
Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cats; Cells, Cultured; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Flavonoids; GTP-Binding Proteins; Imidazoles; Indoles; Intercellular Signaling Peptides and Proteins; Iris; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peptides; Pertussis Toxin; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Receptors, Endothelin; Virulence Factors, Bordetella; Wasp Venoms | 1999 |
Activation of mitogen-activated protein kinase by fumonisin B(1) stimulates cPLA(2) phosphorylation, the arachidonic acid cascade and cAMP production.
Topics: Arachidonic Acid; Bronchi; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carboxylic Acids; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Eicosanoids; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fumonisins; Humans; Isoquinolines; Naphthalenes; Phospholipases A; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Signal Transduction; Sphingolipids; Sulfonamides | 1999 |
Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Enzyme Inhibitors; Flavonoids; Indoles; Isoquinolines; Kinetics; Lysophosphatidylcholines; Myocardium; Nimodipine; Phospholipases A; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Sulfonamides | 1999 |
IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production.
Topics: Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Dinoprostone; Female; Flavonoids; Interleukin-13; Lipoxygenase; Macrophages, Peritoneal; Mice; Phospholipases A; Phosphorylation; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Serine; Signal Transduction; Zymosan | 1999 |
Phosphorylation of cytosolic group IV phospholipase A(2) is necessary but not sufficient for Arachidonic acid release in P388D(1) macrophages.
Topics: Animals; Arachidonic Acid; Calcium; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Kinetics; Lipopolysaccharides; Macrophage Activation; Macrophages; Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Tumor Cells, Cultured | 2000 |
Involvement of protein kinase C, p38 MAP kinase and ERK in arachidonic acid-stimulated superoxide production in human neutrophils.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Superoxides | 1999 |
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
Topics: Arachidonic Acid; Butadienes; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Time Factors; Tumor Cells, Cultured | 2000 |
Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells.
Topics: Animals; Arachidonic Acid; Bone Marrow Cells; Cells, Cultured; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group II Phospholipases A2; Group IV Phospholipases A2; Isoenzymes; Ligands; Mast Cells; Mice; Mice, Inbred CBA; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Receptors, Cell Surface; Receptors, Phospholipase A2; Signal Transduction | 2000 |
Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells.
Topics: Acetophenones; Arachidonic Acid; Benzopyrans; Calcium; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release.
Topics: Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Catalytic Domain; Cell Line; Cell Membrane; Ceramides; Cytosol; Flavonoids; Glomerular Mesangium; Indoles; Liposomes; MAP Kinase Signaling System; Models, Biological; Mutation; Phospholipases A; Phospholipases A2; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Sphingomyelin Phosphodiesterase | 2001 |
Arachidonic acid modulates the spatiotemporal characteristics of agonist-evoked Ca2+ waves in mouse pancreatic acinar cells.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcium Signaling; Cells, Cultured; Cholecystokinin; Enzyme Inhibitors; Flavonoids; Imidazoles; Indomethacin; Kinetics; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Phosphorylation; Pyridines | 2001 |
Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade.
Topics: Animals; Arachidonic Acid; Cation Transport Proteins; Cells, Cultured; Cholecystokinin; Colforsin; DNA-Binding Proteins; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Flavonoids; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Membrane Potentials; Membrane Transport Proteins; Patch-Clamp Techniques; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Protein Kinases; Rats; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Trans-Activators; Transcriptional Regulator ERG; Tyrphostins; Vasoactive Intestinal Peptide | 2001 |
Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosol
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Complement C5a; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Group VI Phospholipases A2; Humans; Imidazoles; Ionophores; Isoenzymes; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Organophosphonates; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
sPLA(2) cooperates with cPLA(2)alpha to regulate prostacyclin synthesis in human endothelial cells.
Topics: Arachidonic Acid; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Flavonoids; Group II Phospholipases A2; Group IV Phospholipases A2; Humans; Isoenzymes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phospholipases A; Time Factors | 2001 |
ERK and p38 MAP kinase are involved in arachidonic acid release induced by H(2)O(2) and PDGF in mesangial cells.
Topics: Animals; Anticoagulants; Arachidonic Acid; Becaplermin; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Oxidants; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Rats; Rats, Sprague-Dawley; Tritium | 2002 |
Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Male; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Rats; Rats, Sprague-Dawley | 2002 |
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.
Topics: Active Transport, Cell Nucleus; Arachidonic Acid; Catalysis; Cell Nucleus; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Green Fluorescent Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Intercellular Signaling Peptides and Proteins; Isoenzymes; Luminescent Proteins; Lymphokines; Male; MAP Kinase Signaling System; Meloxicam; Membrane Proteins; Nitrobenzenes; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thiazines; Thiazoles; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity.
Topics: Animals; Antioxidants; Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2E1; DNA; Flavonoids; Hepatocytes; Humans; Imidazoles; Male; Metalloendopeptidases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Salicylates | 2003 |
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2002 |
Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Biological Transport; Blotting, Western; Cartilage, Articular; Chondrocytes; Cytoplasm; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Activation; Female; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Pyridines; Rabbits; Signal Transduction; Time Factors | 2003 |
The p42/44mitogen-activated protein kinase inhibitor PD 98059, but not U 0126, increases a K+ current in cardiomyocytes.
Topics: Action Potentials; Animals; Arachidonic Acid; Butadienes; Cells, Cultured; Flavonoids; Heart Ventricles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Nitriles; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Tandem Pore Domain; Rats; Rats, Wistar | 2003 |
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Arachidonic Acid; Buspirone; Calcimycin; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Flavonoids; Humans; Indoles; Indomethacin; Maleimides; Pertussis Toxin; Phorbol Esters; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Time Factors; Tryptamines | 2003 |
Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bronchi; Cells, Cultured; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Interferon-gamma; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Organophosphonates; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Pyridines; Pyrones | 2004 |
Signaling mechanisms mediated by G-protein coupled receptors in human platelets.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Antagonists; Adult; Arachidonic Acid; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Drug Synergism; Epinephrine; Female; Flavonoids; Humans; Indomethacin; Male; Platelet Aggregation; Receptors, G-Protein-Coupled; Signal Transduction; Type C Phospholipases; Verapamil; Yohimbine | 2004 |
1alpha,25(OH)2D3 and parathyroid hormone (PTH) signaling in rat intestinal cells: activation of cytosolic PLA2.
Topics: Animals; Arachidonic Acid; Calcitriol; Cytosol; Duodenum; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Male; Mitogen-Activated Protein Kinases; Parathyroid Hormone; Phospholipases A; Phospholipases A2; Phosphorylation; Rats; Rats, Wistar; Signal Transduction | 2004 |
PTH and phospholipase A2 in the aging process of intestinal cells.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Cellular Senescence; Cyclic AMP; Duodenum; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Male; Parathyroid Hormone; Phospholipases A; Phospholipases A2; Phosphorylation; Phosphoserine; Rats; Rats, Wistar | 2004 |
ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite.
Topics: Animals; Arachidonic Acid; Butadienes; Cell Survival; Culture Media; Flavonoids; Humans; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; PC12 Cells; Peroxynitrous Acid; Rats; U937 Cells | 2005 |
MAPKs mediate the activation of cytosolic phospholipase A2 by amyloid beta(25-35) peptide in bovine retina pericytes.
Topics: Amyloid beta-Peptides; Animals; Arachidonic Acid; Biological Transport; Cattle; Cell Nucleus; Cytosol; Enzyme Activation; Flavonoids; Imidazoles; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Pericytes; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Retina; RNA, Messenger | 2005 |
Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells.
Topics: Androstadienes; Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastric Mucins; Gastric Mucosa; Ginkgolides; Lactones; Leptin; Lipopolysaccharides; Organophosphonates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Wortmannin | 2007 |
Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways.
Topics: Animals; Arachidonic Acid; Ascorbic Acid; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Embryonic Stem Cells; Flavonoids; G1 Phase; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation | 2008 |
Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.
Topics: 14-alpha Demethylase Inhibitors; 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Eicosanoids; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, Reporter; Humans; Isoquinolines; Ketoconazole; Luciferases; Mitogen-Activated Protein Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinidine; RNA; Sulfonamides; Transfection | 2011 |
Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension.
Topics: Alkyl and Aryl Transferases; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme System; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Unsaturated; Flavonoids; Hypertension; Infusions, Intravenous; Male; MAP Kinase Signaling System; Organophosphonates; Rats; Rats, Sprague-Dawley; Signal Transduction | 2011 |
Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism.
Topics: Animals; Antioxidants; Arachidonic Acid; Cell Proliferation; Curcumin; Early Growth Response Protein 1; Female; Flavonoids; Humans; Kupffer Cells; Lipid Peroxidation; Liver; Liver Diseases, Alcoholic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2012 |