pd 98059 has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 601 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 53 (8.82) | 18.2507 |
| 2000's | 387 (64.39) | 29.6817 |
| 2010's | 155 (25.79) | 24.3611 |
| 2020's | 6 (1.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| LeRoith, D; Párrizas, M; Saltiel, AR | 1 |
| Coolican, SA; Ewton, DZ; Florini, JR; McWade, FJ; Samuel, DS | 1 |
| Foulstone, E; Haigh, RJ; Nave, BT; Proud, C; Rincon, J; Shepherd, PR; Siddle, K; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Carlsen, J; Christiansen, K; Vinten, J | 1 |
| Alblas, J; Dufourny, B; Steenbergh, PH; Sussenbach, JS; van der Burg, B; van Schaik, FM; van Teeffelen, HA | 1 |
| Coffer, PJ; Geijsen, N; Koenderman, L; Lammers, JW; M'rabet, L; Maikoe, T; Raaijmakers, JA; Schweizer, RC | 1 |
| Brindley, DN; O'Brien, L; Wang, CN | 1 |
| Cheresh, DA; Klemke, R; Li, E; Nemerow, GR; Stupack, D | 1 |
| Bernier, M; Lee-Kwon, W; Park, D | 1 |
| Kanatsuka, A; Makino, H; Onuma, H; Osawa, H; Saito, Y; Suzuki, Y; Taira, M | 1 |
| Anand-Srivastava, MB; Pandey, SK; Srivastava, AK | 1 |
| Greene, LA; Yan, CY | 1 |
| Garlock, GL; Jivraj, S; Stapleton, SR; Wagle, A | 1 |
| Bilney, AJ; Hartfield, PJ; Murray, AW | 1 |
| Bushman, TL; Kuemmerle, JF | 1 |
| Downward, J; Khwaja, A; Lehmann, K; Marte, BM | 1 |
| Frasca, F; Giorgino, F; Gliozzo, B; Goldfine, ID; Milazzo, G; Papa, V; Pezzino, V; Scalia, P; Sciacca, L; Sung, CK; Vigneri, R | 1 |
| Potempa, S; Ridley, AJ | 1 |
| Feldman, EL; Kim, B | 1 |
| Agazie, YM; Halenda, SP; Kaufman, R; Wilden, PA | 1 |
| Blakesley, VA; Gutkind, S; Le Roith, D; Okubo, Y; Stannard, B | 1 |
| Klip, A; Somwar, R; Sumitani, S; Sweeney, G; Taha, C | 1 |
| Birchmeier, W; Brinkmann, V; Hartmann, G; Naundorf, H; Niemann, C; Sachs, M; Spitzer, E | 1 |
| Grossi, M; La Rocca, SA; Pierluigi, G; Ruaro, EM; Schneider, C; Tatò, F; Vannucchi, S | 1 |
| Bulleit, RF; Cui, H; Meng, Y | 1 |
| Cheng, HL; Feldman, EL; Kim, B; Margolis, B | 1 |
| Bracke, M; Coffer, PJ; Koenderman, L; Lammers, JW | 1 |
| Jeong, GB; Kim, EG; Kim, SY; Lee, JY; Park, MK; Shin, EY | 1 |
| Shibuya, M; Takahashi, T; Ueno, H | 1 |
| Piper, HM; Schäfer, M; Schlüter, KD; Simm, A; Taimor, G | 1 |
| Martin, GS; Penuel, E | 1 |
| Ha, J; Kang, I; Kim, J; Kim, JM; Kim, SS; Yoon, MY | 1 |
| Gwag, BJ; Jou, I; Ko, HW; Noh, JS; Ryu, BR | 1 |
| Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C | 1 |
| Chester, AH; Hafizi, S; Yacoub, MH | 1 |
| Ikeda, K; Kawada, N; Kuroki, T; Seki, S | 1 |
| Cavanaugh, JE; Hetman, M; Kanning, K; Xia, Z | 1 |
| Abedi, H; Cospedal, R; Zachary, I | 1 |
| Ai, W; Gong, J; Yu, L | 1 |
| Clemmons, DR; Imai, Y | 1 |
| Chambard, JC; Pouysségur, J; Viñals, F | 1 |
| Mounho, BJ; Thrall, BD | 1 |
| Comella, JX; Encinas, M; Iglesias, M; Llecha, N | 1 |
| Goodyear, LJ; Jakobsen, AB; Lynge, J; Richter, EA; Wojtaszewski, JF | 1 |
| Bandyopadhyay, G; Burke, TR; Farese, RV; Quon, MJ; Sajan, MP; Standaert, ML | 1 |
| Bayascas, JR; Comella, JX; Dolcet, X; Egea, J; Encinas, M; Soler, RM | 1 |
| Roques, M; Vidal, H | 1 |
| Carlsen, J; Christiansen, K; Grunnet, N; Vinten, J | 1 |
| Moelling, K; Zimmermann, S | 1 |
| Gressner, AM; Jansson, JO; Skrtic, S; Wallenius, K | 2 |
| Cheng, HL; Delaney, CL; Feldman, EL | 1 |
| Fujita, Y; Hirasawa, N; Ohuchi, K; Sato, Y | 1 |
| Sánchez-Margalet, V | 1 |
| Bulleit, RF; Hsieh, T | 1 |
| Cook, M; Lowe, WL; Monno, S; Newman, MV | 1 |
| Goto, A; Hirata, Y; Kakoki, M; Nagata, D; Omata, M; Suzuki, E; Yoshizumi, M | 1 |
| Bácsy, E; Bander, E; Buday, L; Faragó, A; Farkas, G; Sipeki, S; Ways, DK | 1 |
| Strayer, DS; White, MK | 1 |
| Ahn, NG; Filmus, J; Kerbel, RS; Mansour, SJ; Mitsuhashi, Y; Rak, J; Sheehan, C; Tamir, A; Viloria-Petit, A | 1 |
| Côté, S; Gingras, S; Simard, J | 1 |
| Bar-Peled, O; Bristol, LA; Coccia, C; Griffin, JW; Ho, TW; Jin, L; Johnson, E; Li, Y; Milbrandt, J; Rothstein, JD | 1 |
| Gentilini, A; Gentilini, P; Marra, F; Pinzani, M | 1 |
| Huper, G; Iglehart, JD; Lobenhofer, EK; Marks, JR | 1 |
| Apostolova, MD; Cherian, MG; Ivanova, IA | 1 |
| Finlay, D; Furlong, F; Healy, V; Keon, NK; Martin, F; O'Connell, FC | 1 |
| Proud, CG; Wang, L; Wang, X | 1 |
| Buridi, A; Coxon, PY; Kettritz, R; Klein, JB; Mathiesen, JM; McLeish, KR; Rane, MJ; Scherzer, JA | 1 |
| Callery, MP; McDade, TP; Perugini, RA; Vittimberga, FJ | 1 |
| Akaike, A; Honda, K; Kihara, T; Nakamizo, T; Sawada, H; Shimohama, S; Urushitani, M | 1 |
| Brodeur, GM; Chou, TT; Eggert, A; Ikegaki, N; Lee, VM; Liu, X; Trojanowski, JQ | 1 |
| Aulitzky, WE; Duyster, J; Götz, A; Hallek, M; Jonuleit, T; Michels, H; Oetzel, C; van der Kuip, H | 1 |
| Akahori, M; Ariga, M; Hakuno, F; Ito, Y; Nedachi, T; Sakamoto, H; Takahashi, S | 1 |
| Fleischmann, M; Iynedjian, PB | 1 |
| Dickenson, JM; Germack, R | 1 |
| Suzuki, K; Takahashi, K | 1 |
| Fred Wong, WS; Tsang, F | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Baumgarten, CM; Dent, P; Fan, S; Gao, B; He, L; Kunos, G; Nguyen, VA; Sheng, X; Spector, M; Woodward, J | 1 |
| Baserga, R; Bossi, G; Cristofanelli, B; Dews, M; Marchetti, A; Morena, AR; Rizzo, MG; Sacchi, A; Soddu, S; Valentinis, B | 1 |
| Bellacosa, A; Billaud, M; Carlomagno, F; Castellone, MD; De Vita, G; Fusco, A; Melillo, RM; Santoro, M; Tsichlis, PN; Visconti, R | 1 |
| Ayala, A; Grutkoski, PS; Leuenroth, SJ; Simms, HH | 1 |
| Boushey, RP; Drucker, DJ; Yusta, B | 1 |
| Huang, CJ; Huang, HM; Yen, JJ | 1 |
| Bale, LK; Conover, CA; Durham, SK; Powell, DR | 1 |
| Chu, CL; Orlow, DL; Reenstra, WR; Svoboda, KK | 1 |
| Grewal, SS; McCleskey, EW; Molliver, DC; Stenberg, PE; Stork, PJ; York, RD | 1 |
| Borg, TK; Carver, W; Kanekar, S; Terracio, L | 1 |
| Balage, M; Dardevet, D; Grizard, J; Sornet, C | 1 |
| Billat, C; Boudot, C; Emonard, H; Fichelson, S; Freyssinier, JM; Haye, B; Hornebeck, W; Kadri, Z; Mayeux, P; Petitfrère, E | 1 |
| Chan, JL; Nguyen, KT; Wang, LH; Wang, WJ | 1 |
| Arbiser, JL; Frank, DA; Ghazizadeh, H; Holden, J; LaMontagne, KR; Mahajan, S; Moses, MA; Wiederschain, D | 1 |
| Asai, T; Chesley, A; Crow, MT; Lakatta, EG; Lundberg, MS; Ohtani, S; Xiao, RP | 1 |
| Behrooz, A; Chen, C; Ismail-Beigi, F; Maity, A; Pore, N | 1 |
| Kuemmerle, JF; Murthy, KS | 1 |
| Lee, J; Mira-Arbibe, L; Ulevitch, RJ | 1 |
| Bellacosa, A; Jeffers, M; Mitsuuchi, Y; Testa, JR; Vande Woude , GF; Xiao, GH | 1 |
| Joaquin, M; Tauler, A | 1 |
| Chen, CS; Dods, P; Gagnon, A; Roustan-Delatour, N; Sorisky, A | 1 |
| Mano, T; Mier, JW; Panka, DJ; Suhara, T; Walsh, K | 1 |
| Dryer, SE; Ko, GY; Ko, ML | 1 |
| Kobayashi, H; Mizisin, AP | 1 |
| Carrillo, JJ; Esteban-Gamboa, A; Felíu, JE; Ibares, B | 1 |
| Baserga, R; Navarro, M | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D | 1 |
| Greenberg, AS; Rosenstock, M; Rudich, A | 1 |
| Chiba, H; Shimoke, K | 1 |
| Hakuno, F; Kurihara, S; Takahashi, S | 1 |
| Aoki, M; Horiuchi, M; Kaneda, Y; Matsumoto, K; Morishita, R; Nakagami, H; Nakamura, T; Ogihara, T; Taniyama, Y; Yamamoto, K | 1 |
| Broxmeyer, HE; Lee, Y | 1 |
| Kimpinski, K; Mearow, K | 1 |
| Barrett, JC; Cykert, DM; Dunn, SE; Oh, JS; Torres, JV | 1 |
| Degger, B; Ding, J; Duan, C; Pozios, KC; Upton, Z | 1 |
| Breittmayer, V; Cambien, B; Millet, MA; Pomeranz, M; Rossi, B; Schmid-Alliana, A; Schmid-Antomarchi, H | 1 |
| Fry, DW; Nelson, JM | 1 |
| Hirota, K; Semenza, GL | 1 |
| Chen, HC; Liang, CC | 1 |
| Aaronson, SA; Fang, L; Lee, SW; Li, G; Liu, G | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Shyr, MH; Wang, CC; Yang, CM | 1 |
| Chang, LC; Wang, JP | 1 |
| Fan, Z; Fang, M; Liu, B; Lu, Y; Mendelsohn, J | 1 |
| Byrnes, HD; Fine, JS; Hipkin, RW; Zavodny, PJ | 1 |
| Harada, T; Morooka, T; Nishida, E; Ogawa, S | 1 |
| Craddock, BL; Edmead, CE; Hobbs, J; Welham, MJ | 1 |
| Bowden, GT; Dong, Z; Kaji, A; Liu, G; Ma, WY; Miyamoto, KI; Nomura, M; Zhong, S | 1 |
| Li, H; Wong, WS | 1 |
| Bakanauskas, VJ; Bernhard, EJ; Cerniglia, GJ; Cheng, Y; Gupta, AK; McKenna, WG; Muschel, RJ | 1 |
| Huggett, TM; Jost, M; Kari, C; Rodeck, U | 1 |
| Buridi, A; Coxon, PY; Kettritz, R; Klein, JB; Manning, T; McLeish, KR; Rane, MJ | 1 |
| Hibi, M; Hirano, T; Kanada, H; Kojima, H; Nagasawa, T; Shimizu, S; Shinagawa, A | 1 |
| Cao, L; Chai, Y; Chen, Z; Cui, R; He, C; Huang, A; Lu, C | 1 |
| Clerk, A; Cole, SM; Pham, FH | 1 |
| Chen, KY; Chiu, SL; Hsu, HY; Hua, KF; Wen, MH | 1 |
| Borski, R; Fruchtman, S; Gift, B; Howes, B | 1 |
| Claes, P; Grobben, B; Roymans, D; Slegers, H | 1 |
| Brossi, A; Ge, YW; Greig, NH; Lahiri, DK; Rogers, J; Sambamurti, K; Shaw, KT; Utsuki, T; Yu, QS | 1 |
| Combes, P; Crumiere, M; Dickenson, JM; Graham, S; Klotz, KN | 1 |
| Antonetti, DA; Barber, AJ; Gardner, TW; Nakamura, M; Reiter, CE; Seigel, GM; Wolpert, EB | 1 |
| Amin, AR; Hamaguchi, M; Ichigotani, Y; Kikkawa, F; Nawa, A; Sein, TT; Thant, AA; Zhang, Y | 1 |
| Chen, C; Sytkowski, AJ | 2 |
| Battaglia, G; Bruno, V; Cuomo, L; D'Onofrio, M; De Blasi, A; Di Iorio, P; Kingston, AE; Ngomba, RT; Nicoletti, F; Orzi, F; Storto, M | 1 |
| Liu, W; Lowe, WL; Newman, M; Shoba, LN | 1 |
| Khwaja, A; Linch, DC; Somervaille, TC | 1 |
| Hara, K; Kawamura, M; Nawa, H; Takei, N; Yonezawa, K | 1 |
| Corwin, JT; Montcouquiol, M; Witte, MC | 1 |
| Badwey, JA; Crossley, L; De Mesquita, DD; Zhan, Q | 1 |
| Pouysségur, J; Viñals, F | 1 |
| García-García, E; Rosales, C; Sánchez-Mejorada, G | 1 |
| Chatterjee, S; D'Andrilli, G; Das, N; Ferlini, C; Marone, M; Scambia, G | 1 |
| Chung, CH; Chung, WJ; Kim, HH; Kwack, KB; Kwak, HB; Lee, SE; Lee, ZH | 1 |
| Cueff, A; De Cian, MC; Lacoste, A; Poulet, SA | 1 |
| Bisotto, S; Fixman, ED | 1 |
| Crawford, JM; Sautin, YY; Svetlov, SI | 1 |
| Holbrook, NJ; Ikeyama, S; Kokkonen, G; Shack, S; Wang, XT | 1 |
| Abe, T; Bamba, T; Kimura, T; Minamiguchi, H; Miyazaki, H; Sonoda, Y; Urata, Y | 1 |
| Hehl, S; Heinemann, SH; Oehrl, W; Schönherr, R; Stoyanov, B; Wetzker, R | 1 |
| Kim, CW; Kim, HH; Kim, SW; Kwack, K; Lee, SE; Lee, SH; Lee, ZH; Walsh, K | 1 |
| Brattain, MG; Dawson, DM; Gupta, A; St Clair, P; Venkateswarlu, S; Willson, JK | 1 |
| Kim, HH; Kim, HM; Kim, SY; Kwack, K; Lee, SE; Lee, ZH; Woo, KM | 1 |
| Bhanot, M; Chan, JL; Le, MT; Nguyen, KT; Sachdev, P; Uttamsingh, S; Wang, LH; Zong, CS | 1 |
| Helfman, DM; Pawlak, G | 1 |
| Awonusonu, F; Bruce, MC; Srinivasan, S; Strange, J | 1 |
| Agazie, Y; Hayman, M; Ischenko, I | 1 |
| Hsu, HY; Wen, MH | 1 |
| Bhat-Nakshatri, P; Nakshatri, H; Sweeney, CJ | 1 |
| Choi, KY; Kim, JA; Oh, SY; Park, KS | 1 |
| Chung, JH; Eun, HC; Kim, DS; Kim, KH; Kim, SY; Park, KC | 1 |
| Freeman, EJ; Silfani, TN | 1 |
| Aizawa, T; Hashizume, K; Iijima, S; Nakajima, K; Shigematsu, S; Yamauchi, K | 1 |
| Choo, HH; Dawe, GS; Tsang, F; Wong, WS | 1 |
| Bell, RM; Mocanu, MM; Yellon, DM | 1 |
| Accurso, FJ; Chan, ED; Cottin, V; Fadok, VA; Hoffmann, F; Kerby, GS; Riches, DW | 1 |
| Gibbs, BF; Grabbe, J; Plath, KE; Wolff, HH | 1 |
| Dryer, SE; Lhuillier, L | 1 |
| Klejman, A; Morrione, A; Rushen, L; Skorski, T; Slupianek, A | 1 |
| Baxter, RC; Kodama, Y; Martin, JL | 1 |
| Fenton, RG; Zhang, B | 1 |
| Choi, SH; Kim, EM; Kim, HS; Kim, S; Lee, S; Lee, SH; Min, K; Park, CH; Rah, JC; Seo, JH; Shin, JK; Suh, SW; Suh, YH | 1 |
| Blomhoff, HK; Myklebust, JH; Rusten, LS; Smeland, EB; Stokke, T | 1 |
| Forough, R; Granger, HJ; Meininger, CJ; Steinle, JJ; Wu, G; Wu, MH | 1 |
| Chin-Chance, C; Lee, EJ; Liu, W; Lowe, WL | 1 |
| Ihn, H; Kubo, M; Tamaki, K; Yamane, K | 1 |
| Gomes, FC; Martinez, R | 1 |
| Chen, TT; Kuo, YH | 1 |
| Bertics, PJ; Dam, P; Kim, YN | 1 |
| Mann, GE; Morgan, AJ; Pearson, JD; Sobrevia, L; Steinert, JR; Sugden, D; Wheeler-Jones, CP; Wyatt, AW | 1 |
| Cieslik, K; Wu, KK; Zhu, Y | 1 |
| Bryckaert, M; Contreres, JO; Lacour, J; Sulpice, E; Tobelem, G | 1 |
| Kalas, W; Kisielow, P; Strzadala, L | 1 |
| Choi, BK; Kim, HH; Kwon, BS; Lee, HW; Nam, KO; Park, SJ | 1 |
| Jegalian, AG; Wu, H | 1 |
| Delwel, R; Jordà, MA; Lowenberg, B | 1 |
| Dirks, KA; Skinner, MK; Uzumcu, M; Westfall, SD | 1 |
| Bhatt, NY; Clanton, TL; Kelley, TW; Khramtsov, VV; Lam, GK; Marsh, CB; Wang, Y | 1 |
| Albanese, C; D'Amico, M; Lee, RJ; Mani, S; Pestell, RG; Wang, C; Wu, K | 1 |
| Andreeff, M; Bondar, VM; McConkey, DJ; Mills, GB; Sweeney-Gotsch, B | 1 |
| Baek, SH; Chung, JH; Jeon, JY; Kim, YD; Lee, JC; Song, SY; Woo, HJ; Yoon, SK | 1 |
| Ahn, JW; Hiraizumi, K; Hong, J; Ohuchi, K; Yamaki, K; Zee, O | 1 |
| Kanda, S; Kanetake, H; Miyata, Y; Mochizuki, Y; Nomata, K; Suematsu, T | 1 |
| Gera, J; Hsu, JH; Hu, L; Lichtenstein, A; Shi, Y; Van Ness, B | 1 |
| Easton, J; Germain, GS; Harwood, FC; Houghton, PJ; Huang, S; Thimmaiah, KN; Veverka, KA | 1 |
| Gadsby, JE; Ge, Z; Hedgpeth, V; Miller, EA | 1 |
| Brodt, P; Zhang, D | 1 |
| Akamatsu, S; Hatakeyama, D; Kozawa, O; Oiso, Y; Shibata, T; Tokuda, H | 1 |
| Bradford, HF; Carney, SL; Goggi, J; Pullar, IA | 1 |
| Lee, JC; Shoba, LN | 1 |
| Brodt, P; Fallavollita, L; Tang, Y; Zhang, D | 1 |
| Brattain, MG; Humphrey, LE; Sawhney, RS; Sharma, B | 1 |
| Blanquet, PR; Derer, P; Mariani, J | 1 |
| Gray, LA; Kaufmann, SH; Mesa, RA; Reeder, T; Schroeder, G; Tefferi, A | 1 |
| Fan, TP; Gherardi, E; Li, RC; Sasisekharan, R; Sellers, LA; Sengupta, S; Watson, N; Zhao, G | 1 |
| Atherton, HC; Danahay, H; Jones, G | 1 |
| Dong, J; Ivanov, VN; Krasilnikov, M; Ronai, Z | 1 |
| Díaz-Laviada, I; Ruiz-Llorente, L; Sánchez, AM; Sánchez, MG | 1 |
| Kiyoi, H; Minami, Y; Naoe, T; Saito, H; Ueda, R; Yamamoto, K | 1 |
| Baldwin, J; Bousquet, P; Chen, M; Dontenwill, M; Dupuy, L; Greney, H; Pascal, G; Piletz, JE; Rondé, P; Takeda, K; Urosevic, D | 1 |
| Amin, MA; Harlow, LA; Koch, AE; Kumar, P; Volpert, OV; Woods, JM | 1 |
| Lau, YL; Law, HK; Liu, E | 1 |
| Agazie, YM; Hayman, MJ; Ischenko, I; Movilla, N | 1 |
| Ito, F; Takeuchi, K | 1 |
| Coppens, A; Hooghe-Peters, E; Kooijman, R | 1 |
| Ishikawa, K; Tokumoto, T; Watanabe, K | 1 |
| Akaike, T; Chowdhury, EH; Hirose, S; Kundu, AK; Nagaoka, M; Sasagawa, T | 1 |
| Araki, E; Hirashima, Y; Igata, M; Kahn, CR; Kodama, S; Toyonaga, T; Tsuruzoe, K; Ueki, K | 1 |
| Chisolm, GM; Gerber, CE; Kottke-Marchant, K; Mukhopadhyay, C; Murugesan, G; Ransohoff, RM; Sandhya Rani, MR | 1 |
| Angelovska, T; Borowiec, AM; Dixon, IM; Freed, DH | 1 |
| Agrawal, DK; DelCore, MG; Hunter, WJ; Krueger, KD | 1 |
| Baltensperger, K; Kirschner, KM | 1 |
| Ishida, E; Kishi, M; Konishi, N; Matsuyoshi, S; Nakamura, M; Shimada, K | 1 |
| Dinh, DH; Gujrati, M; Gumidyala, KV; Mohanam, S; Olivero, WC; Rao, JS; Waldron, KG; Yanamandra, N | 1 |
| DiMattina, AJ; Holland, JA; Johnson, DK; O'Donnell, RW; Stone, RI; Ziegler, LM | 1 |
| Akca, H; Ozes, ON | 1 |
| Fan, D; Wei, L; Yang, Y; Yao, L; You, H; Yu, Q; Zhang, X; Zhao, Y | 1 |
| Bar-Eli, M; Brodt, P; Meloche, S; Zhang, D | 1 |
| Chang, YC; Hsieh, YS; Huang, FM; Liu, CM; Yang, LC; Yang, SF | 1 |
| Azuma, Y; Daito, M; Date, M; Ohura, K; Watanabe, K | 1 |
| Grips, M; Hinzmann, B; Lund, P; Rosenthal, A; Schäfer, R; Schramme, A; Schwendel, A; Sers, C; Tchernitsa, OI; Zuber, J | 1 |
| Kataoka, K; Miura, M; Yu, D | 1 |
| Bau, CJ; Caciagli, F; Ciccarelli, R; Kleywegt, S; Pettifer, KM; Ramsbottom, JD; Rathbone, MP; Vertes, E; Werstiuk, ES | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Cai, SH; Du, J; Nagase, F; Shi, Z | 1 |
| Ben-Ze'ev, A; Kosakowski, M; Lee, P; Libertino, JA; Moinzadeh, A; Rieger-Christ, KM; Stoffel, J; Summerhayes, IC; Zagha, R | 1 |
| Engström, M; Jönsson, JI; Jönsson, M | 1 |
| Draznin, B; Gurerich, I; Leitner, JW; Nadeau, KJ | 1 |
| Cohick, WS; Desury, G; Fleming, J; Hogan, KA; Sivaprasad, U; Verma, PS | 1 |
| Gosmanov, AR; Thomason, DB; Thompson, DB | 1 |
| Chiba, H; Go, M; Ichimiya, S; Kojima, T; Lan, M; Murata, M; Sawada, N; Takano, K; Yamamoto, T | 1 |
| Ostrowski, MC; Patel, K; Rosol, TJ; Sankar, U | 1 |
| Hsieh, HL; Jou, MJ; Yang, CM; Yen, MH | 1 |
| Allen, WE; Campbell, M; Sawyer, C; Trimble, ER; Vanhaesebroeck, B | 1 |
| Deng, JY; Gong, FY; Shi, YF; Zhang, DX | 1 |
| Kondo, T; Kozutsumi, Y; Miyaji, M; Okazaki, T; Taguchi, Y; Umehara, H; Watanabe, M | 1 |
| Anania, FA; Ding, X; Floyd, J; Saxena, NK; Sitaraman, SV; Srinivasan, S; Titus, MA | 1 |
| Chang, CC; Lee, TS; Shyy, JY; Zhu, Y | 1 |
| Franklin, JL; Keeton, AB; Messina, JL; Xu, J | 1 |
| Chiou, WF; Tsai, HR; Tsai, WJ; Yang, LM | 1 |
| Armstrong, DD; Burkholder, TJ; Esser, KA; Hornberger, TA; Koh, TJ | 1 |
| Choi, HJ; Smithgall, TE | 1 |
| O'Rourke, DM; Zhan, Y | 1 |
| Delpiano, AM; Hitschfeld, C; Lavandero, S; Lobos, L; Marusic, ET; Michea, L | 1 |
| Cui, Q; Harvey, AR; Hisheh, S; Luo, JM; Park, K | 1 |
| Li, W; Sumpio, BE | 1 |
| Clowes, AW; Daum, G; Defawe, O; Kenagy, RD; Millette, E; Rauch, BH | 1 |
| Cho, ML; Kim, HY; Kim, KW; Lee, SH; Park, MK; Park, SH; Yoon, CH | 1 |
| Abedin, M; Demer, LL; Lim, J; Radcliff, K; Tang, TB; Tintut, Y; Zhang, Z | 1 |
| Ito, T; Kitamura, H; Okudela, K; Udaka, N; Wang, J; Yazawa, T | 1 |
| Davies, MG; Fegley, AJ; Kim, D; Nicholl, SM; Roztocil, E; Tanski, WJ | 1 |
| Al-Shami, R; Andersson, G; Carson, DD; Ek-Rylander, B; Farach-Carson, MC; Sorensen, ES | 1 |
| Farias, E; Li, X; Lu, M; Schnapp, LM | 1 |
| Inoue, A; Takahashi, S; Takeuchi, S | 1 |
| Blanchard, C; Cuber, JC; Durual, S; Estienne, M; Jacquier, MF; Laboisse, C; Perrot, V | 1 |
| Kim, SH; Kim, TS; Oh, SM | 1 |
| Ahn, JS; Jung, M; Kim, BS; Kim, BY; Kim, GD; Kim, KA; Kim, MS; Kim, SO; Kwon, O; Oh, WK | 1 |
| Ihjima, K; Kawauchi, K; Yamada, O | 1 |
| Axelson, J; Hörlin, K; Lindell, M; Ohlsson, B | 1 |
| Bifulco, K; Campiglia, P; Carriero, MV; Franco, P; Gargiulo, L; Grieco, P; Longanesi-Cattani, I; Peluso, G; Raiola, R; Stoppelli, MP | 1 |
| Charoenfuprasert, S; Fan, CW; Leu, TH; Maa, MC; Yen, CK | 1 |
| Chan, BM; Ho, WC; Morris, VL; Uniyal, S; Zhou, H | 1 |
| Gu, S; Jiang, JX; Villegas, CJ | 1 |
| Anderson, AE; Johnston, LD; Lubin, FD; Sweatt, JD | 1 |
| Akagi, M; Fukuyama, Y; Mitsumoto, Y; Nakade, K; Oda, M; Sakurai, J; Zhai, H | 1 |
| Fang, CH; Hasselgren, PO; Li, BG | 1 |
| de Segura, IA; del Campo, Ede M; Gómez-García, L; Sánchez, FM; Vallejo-Cremades, MT | 1 |
| Kwiecińska, P; Lokociejewska, M; Orzechowski, A; Roszkiewicz, B | 1 |
| Bae, YS; Kim, Y; Kita, H; Lee, YA; Ryu, SH; Shin, MH | 1 |
| Adragna, NC; Lauf, PK; Zhang, J | 1 |
| Burwick, J; Frantz, GD; Fu, L; Hongo, JA; Jubb, AM; Koeppen, H; Strickland, LA; Zhong, F | 1 |
| Li, BQ; Lu, HZ | 1 |
| Lee, MP; Orlov, D; Sweeney, G | 1 |
| Dwyer, DS; Lu, XH | 1 |
| Kanda, S; Kanetake, H; Matsuyama, T; Miyata, Y; Mochizuki, Y | 1 |
| Gajkowska, B; Orzechowski, A; Pajak, B | 1 |
| Motyl, T; Zarzyńska, J | 1 |
| Collman, RG; Freedman, BD; Lee, C; Tomkowicz, B | 1 |
| Bösser, S; Oehme, I; Zörnig, M | 1 |
| Clugston, A; Dransfield, I; Haslett, C; Murray, J; Rossi, AG; Ward, C | 1 |
| Akagawa, K; Omura, T; Osawa, M; Sawai, T; Sunazuka, T | 1 |
| Baek, JH; Hong, WK; Huang, S; Lee, HY; Oh, SH; Papadimitrakopoulou, V; Suh, YA | 1 |
| Aasen, AO; Bjørnland, K; Dahle, MK; Foster, SJ; Myhre, AE; Pettersen, SJ; Thiemermann, C; Wang, JE; Wang, YY | 1 |
| Bae, SS; Bernhard, EJ; Birnbaum, MJ; Fernandes, A; Kim, IA; McKenna, WG; Muschel, RJ; Wu, J | 1 |
| Bacon, J; Bao, Y; Goldson, A; Jakubíková, J; Sedlák, J | 1 |
| Adler, G; Giehl, K; Menke, A; Nguyen-Tat, MD; Vogelmann, R; Wedlich, D | 1 |
| Davis, JS; Finlay, S; Khan, SA; McDonald, CA; Millena, AC; Reddy, S; Vizcarra, J | 1 |
| Chiba, H; Kojima, T; Lan, M; Murata, M; Osanai, M; Sawada, N; Takano, K | 1 |
| Costa, M; Huang, C; Li, J; Shi, X; Tong, Q | 1 |
| Costa, M; Huang, C; Li, J; Ouyang, W; Shi, X | 1 |
| Jo, EK; Jung, SB; Kim, HJ; Lee, JS; Oh, JH; Paik, TH; Park, JK; Song, CH; Yang, CS | 1 |
| Greco, S; Marsigliante, S; Storelli, C | 1 |
| Bardella, C; Coltella, N; Comoglio, PM; Di Renzo, MF; Fassetta, M; Filigheddu, N; Graziani, A; Nano, E; Rasola, A | 1 |
| Anfossi, G; Doronzo, G; Mattiello, L; Russo, I; Trovati, M | 1 |
| Fulton, D; Kotanidou, A; Papapetropoulos, A; Roussos, C; Tsigkos, S; Zakynthinos, S; Zhou, Z | 1 |
| Kariya, Y; Kim, EK; Kim, M; Lee, HK; Lee, JH; Miyazaki, K | 1 |
| Cicha, I; Goppelt-Struebe, M; Graness, A | 1 |
| Gajkowska, B; Hocquette, JF; Orzechowski, A; Pawlikowska, P | 1 |
| Calistri, A; Palù, G; Parolin, C; Sarinella, F; Sette, P | 1 |
| Bae, YS; Baek, SH; Jo, EJ; Jo, SH; Kim, MK; Kim, SD; Lee, C; Lee, HY; Lee, YN; Park, KS; Shin, EH | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Banfic, H; Bertagnolo, V; Brugnoli, F; Matkovic, K; Visnjic, D | 1 |
| Lee, MP; Sweeney, G | 1 |
| Bae, JS; Kim, IS; Kim, JE; Lee, BH; Park, JY; Park, RW | 1 |
| Fu, Y; He, S; Luo, J; Wang, L | 1 |
| Chakrabarti, R; Marzo, E; Scuric, Z; Shen, D; Vadgama, JV; Wu, Y | 1 |
| Aoki, Mdel P; Cano, RC; Coso, OA; Gea, S; Guiñazú, NL; Pellegrini, AV; Tanos, T | 1 |
| Bandobashi, K; Kobayashi, M; Kubota, T; Nakata, H; Saito, T; Taguchi, H; Uemura, Y | 1 |
| Kato, Y; Miura, Y; Oiso, Y; Ozaki, N; Yamada, T | 1 |
| Han, JW; Kang, DW; Kim, SN; Kim, YK; Lee, HY; Seo, DW | 1 |
| Babó, I; Harisi, R; Jeney, A; Kenessey, I; Oláh, J; Pogány, G; Timár, F | 1 |
| Deng, JY; Gong, FY; Shi, YF | 1 |
| Clemente, D; Correa, F; Docagne, F; Guaza, C; Mestre, L | 1 |
| Hansen, PJ; Jousan, FD | 1 |
| Hanai, Y; Kozawa, O; Takai, S; Tokuda, H | 2 |
| Duarte, AI; Oliveira, CR; Proença, T; Rego, AC; Santos, MS | 1 |
| Saisho, H; Tomizawa, M | 1 |
| Gonsalves, C; Johnson, C; Kalra, VK; Kim, KS; Rajagopal, V | 1 |
| Di Segni, A; Farin, K; Pinkas-Kramarski, R | 1 |
| Gajkowska, B; Orzechowski, A; Pawlikowska, P | 1 |
| Jin, L; Kato, A; Tabe, Y | 1 |
| Agrawal, DK; Cheng, G; Jia, G; Kim, MJ | 1 |
| Hamel, M; Price, CA; Sahmi, M; Silva, JM | 1 |
| Kilker, RL; Planas-Silva, MD | 1 |
| Nam, SI | 1 |
| Choi, YH; Heo, MS; Kim, GY; Moon, DO; Park, C; Park, YM | 1 |
| Chen, RJ; Cowart, LA; Jiang, JG; Wang, DW; Wang, JN; Wang, Y; Xia, Y; Xiao, B; Xiao, X; Yang, S | 1 |
| Marsigliante, S; Muscella, A; Romano, S; Storelli, C | 1 |
| Florian, S; Gleixner, KV; Gruze, A; Kondo, R; Mayerhofer, M; Pickl, WF; Rebuzzi, L; Sonneck, K; Thalhammer, JG; Valent, P; Vales, A; Willmann, M | 1 |
| George, C; Kaur, S; Saxena, SK; Singh, M | 1 |
| Ai, W; Chi, AL; Cui, G; Dubeykovskaya, Z; Fleming, JV; Lim, S; Takaishi, S; Tu, S; Wang, TC | 1 |
| Banerji, A; Chakrabarti, J; Chatterjee, A; Mitra, A | 1 |
| Bae, YS; Kim, JM; Kim, MK; Kim, SD; Lee, HY; Lee, SY; Park, KS; Ryu, SH | 1 |
| Hamaguchi, M; Hasegawa, H; Huang, P; Iwamoto, T; Naito, Y; Sohara, Y; Suzuki, N | 1 |
| Li, X; Li, Y; Lin, S; Song, YH; Yu, X; Zhang, S | 1 |
| Carmona-Cuenca, I; Del Castillo, G; Fabregat, I; Fernández, M; Murillo, MM; Ortiz, C; Roncero, C; Sánchez, A | 1 |
| Kanayama, M; Kawai, K; Kudo, H; Kudo, T; Nonome, K; Shinno, E; Sugiyama, T; Tabuchi, Y; Takahara, T; Watanabe, A; Xue, F; Yata, Y | 1 |
| Gocek, E; Kiełbiński, M; Marcinkowska, E | 1 |
| Brustis, JJ; Cottin, P; Daury, L; Leloup, L; Mazères, G | 1 |
| Gus, Y; Karni, R; Levitzki, A | 1 |
| Brown, J; Le, AD; Nishitani, J; Shi, S; Tang, X; Zhang, Q | 1 |
| Seidler, U; Tuo, BG; Wen, GR | 1 |
| Cahill, PA; Cullen, JP; Jin, Y; Morrow, D; Redmond, EM; Sitzmann, JV; von Offenberg Sweeney, N | 1 |
| Cigorraga, SB; Galardo, MN; Meroni, SB; Pellizzari, EH; Riera, MF | 1 |
| Kim, SJ; Kim, TY; Kim, Y; Lee, H; Yoo, H | 1 |
| Chung, H; Moon, M; Park, S; Seo, S | 2 |
| Chen, S; He, S; Lin, Q; Yang, H; Yang, P; Yang, X; Zhang, H; Zhang, Z; Zheng, Y | 1 |
| Honda, K; Miyazaki, T; Ohata, H | 1 |
| Afonyushkin, T; Bochkov, VN; Demyanets, S; Huber, K; Kaun, C; Maurer, G; Pfaffenberger, S; Rega, G; Rychli, K; Wojta, J | 1 |
| Chen, LN; Fan, CM; Jia, JF; Wang, CH; Wang, YH; Zhu, P | 1 |
| Brandimarto, JA; Cohick, WS; Fleming, JM | 1 |
| Bian, JS; Chen, X; Hu, Y; Khin, ES; Lee, SW; Moore, PK; Neo, KL; Pan, TT | 1 |
| Bingle, L; Corke, KP; Fang, WG; Gong, LH; Shi, YH; Wang, YX | 1 |
| Cen, LP; Chiang, SW; Cui, Q; Fan, YM; Huang, Y; Lam, DS; Lin, D; Luo, JM; Pang, CP; van Rooijen, N; Zhang, XM | 1 |
| Chen, DB; Magness, RR; Song, Y; Wang, K; Wen, Y; Zheng, J | 1 |
| Braun, M; Müschenborn, B; Rauch, BH; Schrör, K; Weber, AA | 1 |
| Albrecht, DS; Bomser, JA; Clubbs, EA; Ferruzzi, M | 1 |
| Gómez, R; Gomez-Reino, JJ; Gualillo, O; Lago, F; Lago, R; Otero, M | 1 |
| Berger, F; Champelovier, P; El Atifi, M; Pautre, V; Rostaing, B; Seigneurin, D | 1 |
| Ahn, HS; Jeong, G; Kang, HJ; Koh, SH; Seo, YJ; Shin, HY | 1 |
| Kaneko, Y; Komiyama, K; Moro, I; Mukae, S; Takenouchi-Ohkubo, N | 1 |
| Clawson, GA; Gilliland, K; Smith, TM; Thiboutot, D | 1 |
| Baek, SH; Choi, TY; Hwang, JS; Kim, DH; Kim, JH; Kim, MR; Kwon, HJ; Lee, CH; Yoon, TJ | 1 |
| Covaleda, L; Lungu, G; Martini-Stoica, H; Mendes, O; Stoica, G | 1 |
| Banerji, A; Chatterjee, A; Das, S; Frei, E | 1 |
| Isago, H; Ishiguro, S; Sugano, E; Tamai, M; Tomita, H; Yoshida, H | 1 |
| Hu, Y; Sun, CY; Wang, YD; Zhang, L | 1 |
| Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW | 1 |
| Han, HJ; Lee, MY; Lee, SH | 1 |
| Kim, DY; Kim, JY; Ro, JY | 1 |
| Arshad, F; Braun, AP; Braun, JE; Sheng, JZ | 1 |
| Kerr, C; Li, Y; Richards, CD; Smyth, DC; Tang, D | 1 |
| Chen, Y; Di, J; Lin, Y; Saito, S; Shen, W; Zeng, S; Zhong, Y | 1 |
| Bae, YS; Im, DS; Jo, SH; Kim, JM; Kim, SD; Lee, HY; Lee, SY; Shim, JW; Yun, J | 1 |
| Dash, PR; Harvey, E; LaMarca, HL; Morris, CA; Sullivan, DE; Vishnuthevan, K; Whitley, GS | 1 |
| Aoyama, M; Hirata, J; Kashiwamura, S; Kotani, J; Kuroda, Y; Marukawa, S; Okamura, H; Ueda, H; Usami, M | 1 |
| Chatterjee, K; Honbo, N; Karliner, JS; Tao, R; Zhang, J | 1 |
| Deng, J; Feng, X; Geng, L; Jiang, G; Liu, J; Qian, Y; Wang, Y; Xie, H; Ye, Z; Yin, S; Zheng, S; Zhou, L | 1 |
| Davison, Z; Dutkowski, C; Gee, JM; Heard, CM; Nicholson, RI | 1 |
| Huang, J; Legendre, P; Li, YQ; Wang, W; Wang, YY; Wu, SX | 1 |
| Maghsoudi, N; Moosavi, M; Naghdi, N; Trounce, IA; Yousefpour, M; Zahedi-Asl, S | 1 |
| Kawano, H; Komuta, Y; Sango, K; Si, Y; Yanagisawa, H | 1 |
| Furukawa, Y; Inaba, T; Kurosawa, H; Masuda, M; Matsui, H; Miyagi, J; Nagasaki, A; Ohama, K; Shinjyo, T; Takasu, N | 1 |
| Chen, J; Zhang, F | 1 |
| Chen, Z; Han, Z; Liu, F; Lu, S; Ren, H; Ren, Q; Zhang, L; Zhao, Q | 1 |
| Norlin, M; Pettersson, H; Tang, W | 1 |
| Ikehara, T; Kinouchi, Y; Soda, A; Yoshizaki, K | 1 |
| Irby, RB; Kline, CL; Olson, TL | 1 |
| Belsham, DD; Cai, F; Fick, LJ | 1 |
| Chen, CY; Chen, WC; Fong, YC; Hsu, SF; Huang, CY; Kao, ST; Li, TM; Liu, SC; Tang, CH; Tsai, FJ | 1 |
| Fu, XN; Jiang, JG; Shen, GF; Wang, DW | 1 |
| Blümer, RM; Dubbelhuis, PF; Houben-Weerts, JH; Meijer, AJ; Sauerwein, HP; van Roomen, CP | 1 |
| Dai, T; Fu, GS; Zheng, H | 1 |
| Akhter, S; Chaudhuri, A; Kanmogne, GD; Yang, B | 1 |
| Chan, MC; Hsueh, CM; Lin, LY; Wu, CL; Yang, CH; Yeh, HM | 1 |
| Hultman, KA; Johnson, SL; Scott, AW | 1 |
| Codeluppi, S; Hefferan, MP; Marsala, M; Oshiro, M; Pasquale, EB; Silldorff, MD; Svensson, CI; Valencia, F | 1 |
| Jerczynska, H; Pawlowska, Z | 1 |
| Aleskandarany, M; Ball, G; Douglas Macmillan, R; Ellis, IO; Gee, JM; Green, AR; Habashy, HO; Nicholson, RI; Paish, EC; Powe, DG; Rakha, EA; Staka, CM | 1 |
| Hanada, K; Iwasaki, Y; Kageyama, K; Nigawara, T; Sakihara, S; Suda, T; Takayasu, S | 1 |
| Choi, A; Javadov, S; Karmazyn, M; Kilić, A; Rajapurohitam, V; Zeidan, A | 1 |
| Chan, BM; Morris, VL; Watson, A | 1 |
| Dong, Q; Hou, K; Li, D; Liu, Y; Qu, X; Teng, Y; Zhang, J; Zhang, Y | 1 |
| Baraz, R; Bendall, LJ; Bradstock, KF; Dela Pena, A; Juarez, JG; Thien, M | 1 |
| Chintalwar, GJ; Khanam, S; Raghu, R; Ramakrishnan, R; Sainis, KB; Sharma, D | 1 |
| Bański, P; Kodiha, M; Stochaj, U | 1 |
| Bai, H; Ben, J; Chen, Q; Chen, Y; Gao, S; Ji, Y; Jiang, L; Zheng, Y; Zhong, X; Zhu, X; Zhuang, Y | 1 |
| Blagosklonny, MV; Demidenko, ZN; Shtutman, M | 1 |
| Baek, KH; Jo, AY; Kim, MY; Koh, HC; Lee, HS; Lee, JE; Lee, SH; Lee, YS; Park, CH; Rhee, YH; Shin, I | 1 |
| Chen, W; Li, W; Lin, H | 1 |
| Eastman, B; Gonias, SL; Jo, M; Lester, RD; Montel, V; Takimoto, S | 1 |
| Ben Larbi, S; Bieche, I; Cohen, PA; Dumontet, C; Ghayad, SE; Vendrell, JA | 1 |
| Babo, I; Harisi, R; Jeney, A; Kenessey, I; Olah, JN; Paku, S; Pogany, G; Timar, F | 1 |
| Hong, BZ; Kang, HS; Kim, HG; Kim, HN; Kwak, YG; Ma, TZ; Park, SA | 1 |
| Bouwman, E; Brouwer, E; Doornbos-van der Meer, B; Kallenberg, CG; Limburg, PC; Posthumus, MD; Ueda, Y; van Leeuwen, MA; Westra, J | 1 |
| Kohsaka, S; Maeda, S; Nakajima, K; Tohyama, Y | 1 |
| Mekada, E; Miyamoto, S; Mizushima, H; Wang, X | 1 |
| Chen, DB; Jiang, YZ; Wang, K; Zheng, J | 1 |
| Choi, EJ; Kim, IA; No, M | 1 |
| Khattar, E; Kumar, V | 1 |
| Barja-Fidalgo, C; da-Fé, AR; Fierro, IM; Niconi-de-Almeida, Y; Simões, RL | 1 |
| Davison, Z; Heard, CM; Lee, LM | 1 |
| Han, F; Zhu, HG | 1 |
| Levchenko, V; Pavlov, TS; Staruschenko, A; Vandewalle, A; Wilson, PD; Zheleznova, NN | 1 |
| Huang, L; Sun, S; Sun, X; Wu, Y; Zhang, M | 1 |
| Hao, YY; Iwamori, M; Li, FF; Lin, B; Liu, DW; Liu, JJ; Qi, Y; Zhang, SL; Zhu, LC | 1 |
| Domae, N; Inamura, Y; Kotani, J; Miyamae, M; Sugioka, S | 1 |
| Chai, Y; Hu, DJ; Huang, HL; Luo, X; Tao, QS; Zhang, SQ; Zhang, XL | 1 |
| Blanc, M; Cordier-Bussat, M; Couderc, C; Gouysse, G; Nejjari, M; Roche, C; Scoazec, JY; Vercherat, C; Villaume, K; Walter, T | 1 |
| Bianciardi, P; Joncic, A; Milano, G; Morel, S; Samaja, M; Vassalli, G; von Segesser, LK | 1 |
| Chang, CH; Chang, SC; Chen, CY; Liao, JF; Wen, HC; Yang, SJ | 1 |
| Guyton, RA; Jiang, R; Levy, JH; Tanaka, KA; Vinten-Johansen, J; Wang, NP; Zhao, ZQ | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Nakae, H; Ozaki, K; Yumoto, H | 1 |
| Choi, BT; Choi, YH; Jang, JY; Kim, BW; Lee, JH; Park, C | 1 |
| Liu, J; Wang, W; Yang, J; Zhang, X | 1 |
| Huard, J; Meszaros, LB; Payne, KA; Phillippi, JA | 1 |
| Chen, LL; Chiou, SH; Hung, SC; Lin, HY; Tsai, CC; Wang, YJ | 1 |
| Arnoletti, JP; Frolov, A; Heslin, MJ; Howard, JH; Kossenkov, AV; Kulesza, P; Liles, JS; Tzeng, CW | 1 |
| Barbero, A; Benvenuto, F; Bocelli-Tyndall, C; Di Maggio, N; Iezzi, G; Martin, I; Pistoia, V; Schaeren, S; Scherberich, A; Spagnoli, G; Trella, E; Tyndall, A; Vukcevic, M; Zajac, P | 1 |
| Al-Omran, M; Gupta, M; Lovren, F; Pan, Y; Quan, A; Shukla, PC; Singh, KK; Teoh, H; Verma, S | 1 |
| Han, SH; Kim, SJ; Odathurai Saminathan, S | 1 |
| Darbre, PD; Fry, MJ; Ray, S | 1 |
| Fan, Y; Fu, G; Qiu, F; Xu, S; Yu, L; Zhao, Y | 1 |
| Li, P; Tang, H; Tang, Y; Zhang, W | 1 |
| Bogurcu, N; Debelec-Butuner, B; Erbaykent-Tepedelen, B; Gonen-Korkmaz, C; Korkmaz, KS; Muhammed, HS; Saatcioglu, F; Varisli, L | 1 |
| Chen, S; Kapur, R; Kim, ET; Mali, RS; Munugalavadla, V; Orlando, SA; Wu, X; Yang, FC; Yuan, J | 1 |
| Du, F; Gong, Q; Ke, Y; Qian, ZM; Wu, XM; Yung, WH; Zhu, L | 1 |
| Iwasaki, H; Katano, M; Kumagai, M; Mibu, R; Nakano, K; Onishi, H; Suzuki, H; Wakabayashi, R; Xu, R; Yamasaki, A | 1 |
| Cheng, Q; Dong, W; Peng, Y; Qian, L; Wu, J | 1 |
| Funae, Y; Imaoka, S; Oguro, A; Sakamoto, K | 1 |
| Choi, W; Choi, YH; Kim, BW; Kim, JH; Kim, WJ; Lee, JH; Nam, SW | 1 |
| Bopassa, JC; Eghbali, M; Iorga, A; Li, J; Partownavid, P; Rahman, S; Umar, S | 1 |
| Chai, Y; Huang, HL; Jia, B; Luo, X; Tao, QS; Zhang, SQ; Zhang, XL | 1 |
| Guo, RX; Qiao, YH; Shi, HR; Wang, XY; Zhang, RF | 1 |
| He, P; Lee, SJ; Yoo, BK; Yun, CC | 1 |
| Dong, J; He, YL; Lei, JX; Liao, EY; Sui, GL; Xiao, LW; Xie, H; Yang, M; Yuan, X | 1 |
| Ariyoshi, W; Hida, D; Knudson, CB; Knudson, W; Takahashi, N | 1 |
| Gahtan, V; Lawler, J; Maier, KG; Sadowitz, B; Seymour, KA; Stein, JJ | 1 |
| Chen, JY; Hsu, MC; Hung, WC; Wang, MC; Yang, KT | 1 |
| Chang, KC; Jun, MS; Kim, HJ; Kim, HS; Kim, YM; Kim, YS; Lee, JH; Lee, KR; Park, EJ | 1 |
| Jin, ML; Kim, YH; Lee, SJ; Park, G; Park, SY; Son, HJ | 1 |
| Harbrecht, BG; Nweze, I; Smith, JW; Zhang, B | 1 |
| Chen, Q; Ke, D; Li, G; Wang, L | 1 |
| Alvarez, G; Alvarez-Sala, LA; Cachofeiro, V; Jurado-López, R; Lahera, V; Martín, R; Martinez-Martinez, E; Miana, M; Millán, J; Nieto, ML; Visitación Bartolomé, M; Zuluaga, P | 1 |
| Hao, Y; Hou, R; Iwamori, M; Lin, B; Liu, D; Liu, J; Liu, Q; Liu, S; Zhang, S | 1 |
| Jhiang, SM; Liu, YY; Ringel, MD; Zhang, X | 1 |
| Chung, DC; Duerr, EM; Gala, M; Jo, WS; Kikuchi, H; Mizukami, Y; Moriichi, K; Xavier, RJ | 1 |
| Auersperg, N; Cheng, JC; Leung, PC | 1 |
| He, S; Kong, X; Liu, C; Song, W; Wei, J; Wei, W; Yang, H; Zhang, W | 1 |
| Chen, J; Hong, J; Le, Q; Qian, T; Sun, X; Wu, J; Xu, J; Yu, X | 1 |
| Ayala, P; Boza, P; Catalán, M; Díaz Araya, G; Guzmán, N; Humeres, C; Muñoz, C; Olmedo, I; Varela, M; Vivar, R | 1 |
| Jing, G; Li, J; Lv, Y; Zhu, Y | 1 |
| Harada, T; Itamochi, H; Kawaguchi, W; Kigawa, J; Kudoh, A; Naniwa, J; Nonaka, M; Oishi, T; Sato, S; Shimada, M; Terakawa, N; Uegaki, K | 1 |
| Banerjee, G; Chatterjee, S; Dias, PM; Joshi, MK; Majumder, S; Siamwala, JH; Sinkar, VP | 1 |
| Fan, J; Ren, Y; Yin, G; Zhang, Z; Zhou, W | 1 |
| He, L; Miller, RS; Pine-Twaddell, E; Radovick, S; Romero, CJ; Sima, DI; Wondisford, F | 1 |
| Akpan, A; Burlingame, A; Corless, S; Cramer, R; Naaby-Hansen, S; Nagano, K; Stein, R; Stensballe, A; Timms, JF; Totty, N; Warnasuriya, G; Waterfield, M; Yang, A; Zvelebil, M | 1 |
| Chang, YC; Huang, FM; Lee, SS; Tsai, CH | 1 |
| Fu, G; Li, H; Li, J; Li, Z; Liu, H; Zhang, P | 1 |
| Jiang, Y; Tian, J | 1 |
| Radhika, A; Sudhakaran, PR | 1 |
| Chen, BR; Chen, PF; Cheng, HH; Lin, WC; Liou, JY; Wang, KH; Wu, KK | 1 |
| Fang, XX; Han, XH; Jiang, XL; Peng, YP; Qiu, YH | 1 |
| Chang, YC; Huang, FM; Kuan, YH; Lee, SS; Tsai, CH | 1 |
| Bode, AM; Cao, Y; Chen, L; Dong, Z; Li, H; Li, L; Li, W; Li, Z; Liu, H; Liu, S; Tang, M; Tao, Y; Yang, L | 1 |
| Deng, XL; Li, GR; Su, XL; Wang, Y; Zhao, LM | 1 |
| Bian, XW; Chen, GL; Cui, YH; Duan, JJ; Gu, A; Li, TT; Qian, C; Shi, Y; Xin, YH; Xu, C; Yang, XJ; Yu, SC; Zhang, X | 1 |
| Fernández-Galilea, M; Martínez, JA; Moreno-Aliaga, MJ; Pérez-Matute, P; Prieto-Hontoria, PL | 1 |
| Cantarella, C; Ferrari, MC; Fioretti, F; Paolella, G; Sepe, L | 1 |
| Gao, X; Lu, C; Sun, L; Sun, X; Zhou, L | 1 |
| Amagai, Y; Ishizaka, S; Jang, H; Jung, K; Matsuda, A; Matsuda, H; Nishikawa, S; Oida, K; Tanaka, A | 1 |
| Kotsimbos, TC; Levvey, BJ; Meehan, AC; Mifsud, NA; Nguyen, TH; Snell, GI; Westall, GP | 1 |
| Kakudo, N; Kushida, S; Kusumoto, K; Morimoto, N; Ogawa, T | 1 |
| Elsum, IA; Humbert, PO; Martin, C | 1 |
| Chang, CD; Chang, CI; Hsu, JL; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL | 1 |
| Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ | 1 |
| Cui, BR; Cui, X; Ding, DZ; Hong, L; Li, HY; Li, P; Liu, LP; Zhang, QL | 1 |
| Andotra, SS; Bhat, WW; Bhushan, S; Guru, SK; Joshi, A; Kumar, A; Kumar, S; Malik, FA; Pathania, AS; Saxena, AK; Shah, BA; Sharma, PR; Singh, J; Taneja, SC | 1 |
| Konończuk, J; Pałka, J; Prokop, I; Surażyński, A | 1 |
| DiGiovanni, J; Jiang, G; Kiguchi, K; Rho, O | 1 |
| Ding, X; Dong, S; Gao, J; Ke, S; Kong, F; Kong, J; Sun, W; Wang, S; Zheng, L | 1 |
| Bai, J; Chen, YN; Liu, H; Liu, Y; Wang, Y; Zhao, HB; Zhu, XJ | 1 |
| Ji, QY; Meng, LJ; Wang, H; Wang, Y; Xing, FJ; Yang, ST; Zhang, HS; Zhang, HY; Zhao, JW | 1 |
| Chang, HH; Huang, YM; Juan, CC; Kao, CC; Kao, YH; Kuo, YC; Liu, CW; Tang, YC | 1 |
| Cheng, SE; Chi, PL; Hsiao, LD; Hsu, CK; Lee, IT; Yang, CM | 1 |
| Lin, YQ; Luo, NS; Mai, J; Qiu, Q; Wang, JF; Wen, ZZ; YangXin, C; Zhang, HF | 1 |
| He, S; Li, T; Wei, J; Yang, H; Zhang, H | 1 |
| Hyun, SK; Jin, KS; Kim, BW; Kwon, HJ; Oh, YN | 1 |
| Ge, H; Rao, W; Shen, L; Song, F; Wang, S; Wang, Y; Xie, G; Yin, Q; Zhang, H; Zhang, R; Zhang, Y | 1 |
| Jiang, J; Li, D; Li, W; Liu, W; Ma, Y; Qu, Z; Ruan, Q; Yan, D; Yang, L | 1 |
| Cui, H; Li, L; Yang, Y; Zhang, C; Zhang, X; Zhu, C | 1 |
| Han, HD; Kang, TH; Kim, JH; Kim, K; Kim, SH; Kim, TW; Kumar, V; Lee, KM; Lee, YH; Ng, J; Noh, KH; Song, KH; Sonn, CH; Sood, AK; Yee, C | 1 |
| Hou, Y; Jeong, CH; Jeun, SS; Jun, JA; Kim, SM; Ryu, CH | 1 |
| Cong, B; Li, X; Liu, B; Ni, X; Wang, L; Zhu, X | 1 |
| Kirschner, MW; Li, VC | 1 |
| Guo, TQ; Liu, DP; Liu, Y; Lu, JH; Meng, QF; Teng, LS; Wang, D; Wang, ZY; Xie, J; Zhang, XL | 1 |
| Nakashima, Y; Takahashi, S | 1 |
| Chen, L; Cheng, MN; Fang, H; Han, XH; Li, XT; Qu, ZQ; Wang, LJ | 1 |
| Disheng, Y; Jinwei, X; Liang, Z; Mengxuan, D; Renfu, Q; Rongliang, C; Zongbao, Y | 1 |
| Angel, J; Busca, A; Iqbal, S; Kumar, A; Saxena, M | 1 |
| Kimura, M; Moteki, H; Ogihara, M | 1 |
| Chen, G; Cheng, X; Guo, Y; Jin, G; Li, H; Li, P; Lu, X; Qin, J; Sun, X; Tian, M; Zhang, L; Zhang, X; Zhou, H | 1 |
| Chen, L; Cheng, Y; Feng, W; Li, X; Lin, L; Lu, X; Shi, H; Wang, Y; Wang, Z; Xiang, L; Xiao, J; Ye, J; Yu, X; Zhang, H | 1 |
| Kluftinger, A; Little, JP; Mah, D; Simtchouk, S; Wan, Z | 1 |
| Huang, BS; Li, K; Li, LX; Li, S; Lu, XC; Tang, LJ; Tao, Y; Yu, W; Zheng, JY; Zhu, RL | 1 |
| Getzenberg, RH; Liu, Z; Veltri, RW; Zhu, G | 1 |
| Go, KC; Hyun, MY; Kim, BJ; Kim, SY; Zouboulis, CC | 1 |
| Kedikaetswe, A; Lim, NR; May, CN; Ng, DC; Thomas, CJ; Woodman, OL; Yeap, YY | 1 |
| Chen, BX; Du, FH; Guo, CX; Jiang, X; Li, HH; Zeng, XJ | 1 |
| Chen, H; Chen, J; Chen, W; Feng, X; Gao, X; Geng, L; Kong, W; Li, X; Liu, R; Shi, B; Sun, L | 1 |
| Du, ZD; Hu, LT; Li, Y; Ma, ZZ; Zhao, GQ | 1 |
| Burmina, YV; Chaikovskii, AV; Danilets, MG; Dygai, AM; Minakova, MY; Miroshnichenko, LA; Shults, EE; Simanina, EV; Stavrova, LA; Tolstikova, TG; Udut, EV; Udut, VV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Choi, S; Jiao, HY; Jun, JY; Kim, MW; Kim, SW; Lee, MJ; Na, J; Park, CG; Park, IK; Shin, DH; So, I | 1 |
| Gan, W; Han, Y; Li, S; Wang, B; Zhang, A | 1 |
| Chen, HM; Gu, L; Hu, YR; Li, JM; Liao, XB; Luo, JW; Shen, KJ; Tan, CM; Yuan, ZS; Zhou, XM; Zhou, YZ | 1 |
| Koh, SA; Lee, KH | 2 |
| Ghasemi, R; Maghsoudi, N; Moosavi, M; Rastegar, K; Zarifkar, A | 1 |
| Chen, Y; Hu, SY; Tian, F; Wang, S; Yin, T; Zhang, Y | 1 |
| Cao, XL; Dong, W; Hu, XM; Min, ZL; Wang, F; Wang, J; Wu, FJ; Xiao, W; Xing, H; Xu, SQ; Ying, TZ; Zhang, Y; Zheng, WX | 1 |
| Agafonov, VI; Burmina, YV; Chaikovskii, AV; Dygai, AM; Khrichkova, TY; Miroshnichenko, LA; Reikhart, DV; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Chen, L; Feng, F; He, L; Li, L; Li, X; Liu, W; Lv, D; Qin, X; Xie, F | 1 |
| Jiang, R; Wang, L; Wei, L; Wu, J; Zhu, M | 1 |
| Jin, Y; Li, C; Li, Z; Liu, X; Sun, L; Xing, R; Yang, L; Zhao, J | 1 |
| Klausen, C; Leung, PC; Ma, L; Peng, B; Wang, YL; Zhu, H | 1 |
| Chen, H; Peng, L; Wang, R; Zhang, L; Zhang, X; Zhao, J; Zheng, W | 1 |
| Deng, H; Fu, W; Li, E; Tian, S; Wang, B; You, Y | 1 |
| Li, H; Li, Z; Liu, D; Liu, H; Liu, Z; Pan, X | 1 |
| Du, M; Li, C; Quan, R; Shi, Y; Xu, J; Yang, D; Yang, Z; Zhang, L | 1 |
| Bhardwaj, SK; Little, PJ; Quirion, R; Srivastava, LK; Wang, X; Zeng, Z; Zheng, W; Zhou, X | 1 |
| Chong, CM; Fang, J; Lazarovici, P; Meng, Q; Wang, H; Wang, R; Zhang, L; Zheng, W; Zhou, X | 1 |
| Arunachalam, P; Ebenezer, AJ; Elden, BT | 1 |
| Archambault, E; Cynober, L; Goron, A; Guihenneuc, C; Jourdan, M; Le Plénier, S; Moinard, C; Neveux, N; Salles, J; Sotiropoulos, A; Walrand, S | 1 |
| Agafonov, VI; Chaikovskii, AV; Dygai, AM; Khrichkova, TY; Minakova, MY; Miroshnichenko, LA; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Chen, J; Farhan, M; Liao, R; Little, PJ; Wang, T; Wang, Z; Yan, F; Zheng, W | 1 |
| DeGregorio, MW; Kao, CJ; Lin, YC; Phong, B; Vang, DP; Wurz, GT | 1 |
| Cho, SW; Jung, HI; Jung, JK; Kim, JY; Kim, KR; Lee, Y; Neupane, S; Shin, HI; Sohn, WJ; Yamamoto, H | 1 |
| Chung, DH; Ha, GH; Hwang, KR; Jeon, YK; Kim, CK; Koh, J; Lee, CW; Park, HY | 1 |
| Chen, L; Chen, WF; Chen, XH; Du, ZR; Teng, JJ; Wong, MS; Wu, L; Xu, AL | 1 |
| Cui, C; Cui, J; Cui, Y; Gao, J; Jiang, X; Li, R; Sheng, H; Tian, Y; Wang, K | 1 |
| Cho, JH; Jeong, HS; Kim, DS; Kim, MK; Kwon, NS; Lee, H; Shin, JS; Yun, HY | 1 |
| Fu, J; Hu, Y; Jia, P; Li, G; Liu, B; Lu, C; Sun, Y; Zhao, J | 1 |
| Fan, YX; Liu, YT; Luo, YH; Wang, LJ; Wen, J; Yan, PW; Zhang, Q; Zhu, HF | 1 |
| Almeida, VH; Berzoti-Coelho, MG; Borges, CS; Cacemiro, MDC; Castro, FA; Ferreira, AF; Figueiredo-Pontes, LL; Gomes, FG; Monteiro, RQ; Nunes, NS; Simões, BP | 1 |
| Cong, M; Jing, R; Li, H; Li, J; Li, Z; Qiao, Y | 1 |
| Cao, L; Han, L; Li, W; Ma, Q; Wang, Z; Wu, Z; Xiao, X | 1 |
| Agafonov, VI; Dygai, AM; Minakova, MY; Miroshnichenko, LA; Polyakova, TY; Sherstoboev, EY; Simanina, EV; Stavrova, LA; Udut, EV; Zhdanov, VV; Zyuz'kov, GN | 1 |
| Hou, M; Ji, M; Song, J; Sun, H; Wei, C; Xing, J; Xu, T; Xu, Z; Yang, B; Yang, Z; Yu, Z; Zhang, H; Zhang, Y | 1 |
| Fujita, S; Inui, T; Kobayashi, M; Murayama, S; Ogiso, B; Takei, H; Yamamoto, K | 1 |
| Cortés, M; Darling, DS; Ninfali, C; Postigo, A; Siles, L | 1 |
| Chen, S; Guo, Y; Huang, Y; Lu, Y; Wang, Z; Xu, L; Xu, Y | 1 |
| Huo, C; Jia, X; Li, X; Liu, Y; Wang, X; Xiao, Y; Xu, R | 1 |
| Li, J; Li, L; Li, X; Li, Y; Li, Z; Shi, C; Wei, J; Wu, Y; Zhang, Y | 1 |
| Fang, H; Shi, X; Yang, Y; Ye, L; Yu, W; Zhang, S; Zhu, H; Zhu, M | 1 |
| Ito, M; Matsubara, T; Minato, T; Miyabe, M; Nakamura, N; Naruse, K; Saiki, T; Sango, K | 1 |
| Okada, M; Otani, K; Sagara, A; Yamamoto, A; Yamawaki, H | 1 |
| Li, G; Li, JZ; Qiang, HF; Wang, Y; Wu, WY; Xiao, GS; Zhou, XX | 1 |
2 review(s) available for pd 98059 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
[Study of drugs against neoplastic metastasis].
Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibitors; Fatty Alcohols; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Morpholines; Neoplasm Metastasis; Paclitaxel; Pyridines; Ribavirin; Signal Transduction; Sirolimus | 2006 |
1 trial(s) available for pd 98059 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition.
Topics: Acetophenones; Adult; Benzopyrans; Cells, Cultured; Chromones; Cyclosporine; Female; Flavonoids; Humans; Immunosuppressive Agents; Interferon-gamma; Killer Cells, Natural; Lung Transplantation; Lysosomal-Associated Membrane Protein 1; Male; Morpholines; Mycophenolic Acid; Prednisolone | 2013 |
598 other study(ies) available for pd 98059 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways.
Topics: Androstadienes; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Drug Synergism; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Morpholines; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1997 |
The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Developmental; Genes, fos; Insulin-Like Growth Factor I; Mitogens; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Somatomedins | 1997 |
Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism.
Topics: 3-O-Methylglucose; Adult; Androstadienes; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glycogen Synthase; Humans; Insulin; Male; Mitogen-Activated Protein Kinase 1; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Wortmannin | 1997 |
Insulin stimulated glycogen synthesis in isolated rat hepatocytes: effect of protein kinase inhibitors.
Topics: Androstadienes; Animals; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Hypoglycemic Agents; Insulin; Liver; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1997 |
Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.
Topics: Breast Neoplasms; Cell Division; Chromones; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Replication; Enzyme Inhibitors; Female; Flavonoids; G1 Phase; Humans; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.
Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Cytokines; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activating Factor; Protein Kinase Inhibitors; Protein Kinases; Respiratory Burst; Signal Transduction; Wortmannin; Zymosan | 1998 |
Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cell Membrane Permeability; Ceramides; Chromones; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Mice; Models, Biological; Monosaccharide Transport Proteins; Morpholines; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polyenes; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha | 1998 |
Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase.
Topics: Adenoviruses, Human; Androstadienes; Antigens, CD; Catalysis; Cell Adhesion Molecules; Chromones; Cyclosporins; Endocytosis; Enzyme Activation; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin alphaV; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Wortmannin | 1998 |
Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin.
Topics: Adipocytes; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Polyunsaturated Alkamides; Protein Prenylation; Proteins; ras Proteins; Receptor, Insulin; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Wortmannin | 1998 |
Mitogen-activated protein kinase and p70 ribosomal protein S6 kinase are not involved in the insulin-dependent stimulation of cAMP phosphodiesterase kinase in rat adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Amino Acid Sequence; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell-Free System; Chromones; Epidermal Growth Factor; Epididymis; Flavonoids; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Male; Molecular Sequence Data; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Polyenes; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 1998 |
Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; Enzyme Activation; Flavonoids; Glycogen; Humans; Insulin Receptor Substrate Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polyenes; Receptor, Insulin; Ribosomal Protein S6 Kinases; Sirolimus; Tyrosine; Vanadium Compounds; Wortmannin | 1998 |
Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway.
Topics: Acetylcysteine; Androstadienes; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression Regulation; Genes, Immediate-Early; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Nitric Oxide Synthase; PC12 Cells; ras Proteins; Rats; Signal Transduction; Wortmannin | 1998 |
Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Flavonoids; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Insulin; Liver; Lovastatin; Male; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Wortmannin | 1998 |
Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.
Topics: Amino Acid Chloromethyl Ketones; Androstadienes; Animals; Apoptosis; Cell Survival; Chromones; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Hypoglycemic Agents; Insulin; Morpholines; Nerve Growth Factors; Neurons; Neuropeptides; Neuroprotective Agents; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Sphingosine; Thionucleotides; Wortmannin | 1998 |
IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; Jejunum; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Thymidine; Time Factors | 1998 |
Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dogs; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; GTP Phosphohydrolases; Hepatocyte Growth Factor; Kidney Tubules; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Signal Transduction | 1998 |
Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Transformed; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Ribosomal Protein S6 Kinases; Tumor Cells, Cultured; Tyrosine | 1998 |
Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly.
Topics: Animals; beta Catenin; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Line; Chromones; Cytoskeletal Proteins; Desmosomes; Dogs; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; GTP-Binding Proteins; Hepatocyte Growth Factor; Intercellular Junctions; Kidney; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; rac GTP-Binding Proteins; ras Proteins; Signal Transduction; Trans-Activators; Transfection | 1998 |
Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Chromones; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Chromones; Coronary Vessels; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Signal Transduction; Swine; Wortmannin | 1998 |
Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase.
Topics: Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Kidney; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Stress, Physiological; Transfection; Tumor Necrosis Factor-alpha | 1998 |
Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms.
Topics: Androstadienes; Animals; Cell Line; Chromones; Clone Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Homeostasis; Indoles; Insulin; Kinetics; Maleimides; Models, Biological; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors; Wortmannin | 1998 |
Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.
Topics: Androstadienes; Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Chromones; Enzyme Inhibitors; Flavonoids; Glycoproteins; Hepatocyte Growth Factor; Humans; Mammary Glands, Animal; Mice; Microscopy, Electron; Morphogenesis; Morpholines; Neuregulins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-met; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Wortmannin | 1998 |
Role of Gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src.
Topics: 3T3 Cells; Animals; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Chromones; Down-Regulation; Flavonoids; Gene Expression; GPI-Linked Proteins; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogens; Morpholines; Oncogene Protein pp60(v-src); Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction | 1998 |
Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells.
Topics: Animals; Antimanic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Cerebellum; Chromones; Diphosphonates; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin-Like Growth Factor I; Lithium Chloride; Mice; Mice, Inbred Strains; Mitogens; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Stem Cells; Thymidine; Tritium | 1998 |
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Cell Membrane; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Models, Biological; Morpholines; Neurites; Neuroblastoma; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Transfection; Tumor Cells, Cultured; Wortmannin | 1998 |
Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; Immunoglobulin A; Immunoglobulin G; Interleukin-4; Interleukin-5; Microspheres; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Pyridines; Receptors, Fc; Receptors, IgG; Rosette Formation; Signal Transduction; Th2 Cells; Wortmannin | 1998 |
H-Ras is a negative regulator of alpha3beta1 integrin expression in ECV304 endothelial cells.
Topics: Antibodies; Cell Line, Transformed; Cell Movement; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Endothelium; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, Dominant; Humans; Imidazoles; Integrin alpha3beta1; Integrins; Morpholines; Oncogene Protein p21(ras); Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Transfection; Up-Regulation | 1999 |
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcinogens; Cardiomegaly; Cells, Cultured; Chromones; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Heart Ventricles; Indoles; Isoenzymes; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Wortmannin | 1999 |
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chick Embryo; Chromones; Colony-Forming Units Assay; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression Regulation; Genes, ras; Genes, src; Hexoses; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Transformation, Genetic | 1999 |
Phosphatidylinositol 3-kinase regulates differentiation of H9c2 cardiomyoblasts mainly through the protein kinase B/Akt-independent pathway.
Topics: Animals; Cell Differentiation; Cell Line; Cell Size; Chromones; Flavonoids; Genes, Dominant; Heart; Insulin; Mitogen-Activated Protein Kinase 1; Morpholines; Mutation; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; RNA, Messenger; Signal Transduction; Transfection | 1999 |
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Iron; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Necrosis; Neocortex; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphorylation; Staurosporine; Wortmannin | 1999 |
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1999 |
Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Fibroblasts; Fibrosis; Flavonoids; Heart; Humans; Morpholines; Myocardium; Phosphoinositide-3 Kinase Inhibitors | 1999 |
Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; Bucladesine; Cell Cycle; Cell Division; Cells, Cultured; Chromones; Cyclin D1; Cyclin D2; Cyclin E; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Inhibitors; Flavonoids; G1 Phase; Imidazoles; Liver; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; S Phase; Thymidine; Tritium | 1999 |
Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Camptothecin; Cells, Cultured; Cerebral Cortex; Chromones; Culture Media, Serum-Free; Flavonoids; Morpholines; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Topoisomerase I Inhibitors | 1999 |
Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases.
Topics: Androstadienes; Animals; Aorta; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Focal Adhesion Protein-Tyrosine Kinases; Insulin-Like Growth Factor I; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rabbits; Stimulation, Chemical; Wortmannin | 1999 |
MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Maleimides; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Opioid, mu; Recombinant Proteins; Thionucleotides; Transfection; Wortmannin | 1999 |
Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic acid synthesis by insulin-like growth factor-I.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Chromones; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Vitronectin; Swine; Wortmannin | 1999 |
p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; DNA Replication; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; G1 Phase; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Biosynthesis; Ribosomal Protein S6 Kinases; Sirolimus; Thymidine | 1999 |
The extracellular signal-regulated kinase pathway contributes to mitogenic and antiapoptotic effects of peroxisome proliferators in vitro.
Topics: Animals; Apoptosis; Cells, Cultured; Chamomile; Chromones; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flavonoids; Immunohistochemistry; Liver; Male; Mice; Mitogens; Morpholines; Oils, Volatile; Peroxisome Proliferators; Phosphorylation; Phosphotransferases; Plants, Medicinal; Pyrimidines; Signal Transduction | 1999 |
Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y.
Topics: Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Survival; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factors; Neurites; Neuroblastoma; Neuroprotective Agents; Neurotrophin 3; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Receptor, trkC; Receptors, Nerve Growth Factor; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin; Tumor Cells, Cultured | 1999 |
Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications.
Topics: Amino Acids; Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen Synthase; Insulin; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Muscle Contraction; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 1999 |
Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adipocytes; Amino Acid Substitution; Androstadienes; Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Epididymis; Flavonoids; Genistein; Insulin; Kinetics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Recombinant Proteins; Signal Transduction; src Homology Domains; Threonine; Wortmannin | 1999 |
Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons.
Topics: Animals; Cell Survival; Chick Embryo; Chromones; Culture Media, Conditioned; Drosophila Proteins; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; In Situ Hybridization; Mitogen-Activated Protein Kinases; Morpholines; Motor Neurons; Muscles; Nerve Growth Factors; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spinal Cord | 1999 |
A phosphatidylinositol 3-Kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells.
Topics: Adult; Cells, Cultured; Chromones; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glycogen Synthase; Humans; Insulin; Insulin Receptor Substrate Proteins; Middle Aged; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Transcription, Genetic | 1999 |
Involvement of PI 3-kinase and activated ERK in facilitating insulin-stimulated triacylglycerol synthesis in hepatocytes.
Topics: Acetyl-CoA Carboxylase; Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Glucose; Insulin; Liver; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sirolimus; Triglycerides; Wortmannin | 1999 |
Phosphorylation and regulation of Raf by Akt (protein kinase B).
Topics: Cell Division; Cell Line; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Fusion Proteins; Signal Transduction; Somatomedins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Insulin-like growth factor signaling pathways in rat hepatic stellate cells: importance for deoxyribonucleic acid synthesis and hepatocyte growth factor production.
Topics: Animals; Chromones; DNA; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Liver; Male; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus | 1999 |
Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Chromones; Colforsin; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Insulin; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve | 1999 |
Involvement of a phosphatidylinositol 3-kinase-p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells.
Topics: Activating Transcription Factor 2; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP Response Element-Binding Protein; Dinitrophenols; Enzyme Activation; Flavonoids; Imidazoles; Interleukin-4; Mast Cells; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Serum Albumin; Transcription Factors; Wortmannin | 2000 |
Stimulation of glycogen synthesis by insulin requires S6 kinase and phosphatidylinositol-3-kinase in HTC-IR cells.
Topics: Animals; Chromones; Enzyme Inhibitors; Flavonoids; Glycogen; Glycogen Synthase; Humans; Immunophilins; Insulin; Insulin Receptor Substrate Proteins; Isoenzymes; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus Binding Proteins; Tumor Cells, Cultured; Tyrosine | 2000 |
MEK inhibitors block BDNF-dependent and -independent expression of GABA(A) receptor subunit mRNAs in cultured mouse cerebellar granule neurons.
Topics: Animals; Blood Proteins; Brain-Derived Neurotrophic Factor; Calcium Channel Blockers; Cell Differentiation; Cells, Cultured; Cerebellum; Chromones; Cytomegalovirus; Cytoplasmic Granules; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neurons; Neuropeptides; Neurotrophin 3; Phosphoinositide-3 Kinase Inhibitors; Pituitary Adenylate Cyclase-Activating Polypeptide; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptors, GABA-A; RNA, Messenger; Veratridine | 2000 |
Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genes, Reporter; Humans; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Morpholines; Phosphorylation; Protein Kinases; Tumor Cells, Cultured | 2000 |
Reentry into the cell cycle of contact-inhibited vascular endothelial cells by a phosphatase inhibitor. Possible involvement of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Communication; Cell Cycle; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Intercellular Junctions; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Signal Transduction | 2000 |
Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering.
Topics: Carcinoma, Hepatocellular; Cell Movement; Chromones; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitin-Protein Ligases | 1999 |
Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells.
Topics: Animals; Benzoquinones; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genistein; Insulin Receptor Substrate Proteins; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinones; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Rifabutin; Tyrosine | 2000 |
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chromones; Endothelial Growth Factors; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Flavonoids; Gene Expression Regulation; Genes, ras; Intestinal Mucosa; Kinetics; Lymphokines; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Morpholines; Neoplasms, Experimental; Neovascularization, Pathologic; Rats; Signal Transduction; Thrombospondin 1; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Progesterone Reductase; Signal Transduction; STAT6 Transcription Factor; Steroid Isomerases; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Wortmannin | 2000 |
TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity.
Topics: Androstadienes; Animals; Axons; Chromones; Cloning, Molecular; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Humans; Kinetics; Morpholines; Motor Neurons; Nerve Growth Factors; Nerve Tissue Proteins; Neurturin; Nodal Protein; Organ Culture Techniques; Rats; Recombinant Proteins; Spinal Cord; Transforming Growth Factor beta; Wortmannin | 2000 |
Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells.
Topics: Androstadienes; Cell Division; Cell Movement; Cells, Cultured; Chemotactic Factors; Chromones; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; Liver; Mitogen-Activated Protein Kinases; Mitogens; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Wortmannin | 2000 |
Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
Topics: Adenocarcinoma; Androstadienes; Breast Neoplasms; Butadienes; Chromones; Culture Media, Serum-Free; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Depression, Chemical; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Flavonoids; Fulvestrant; Humans; Isoquinolines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Morpholines; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Sulfonamides; Wortmannin | 2000 |
Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cell Nucleus; Chromones; Cytoplasm; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Metallothionein; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Sirolimus; Zinc | 2000 |
MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Epithelial Cells; Extracellular Matrix; Female; Flavonoids; Imidazoles; Mammary Glands, Animal; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines | 2000 |
Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps.
Topics: Age Factors; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Heart Ventricles; Hypoglycemic Agents; Immunosuppressive Agents; Insulin; Intracellular Signaling Peptides and Proteins; Methionine; Morpholines; Muscle Fibers, Skeletal; Myocardium; Peptide Elongation Factor 2; Peptide Initiation Factors; Phenylalanine; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Sulfur Radioisotopes; Tritium | 2000 |
Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways.
Topics: Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Cells, Cultured; Chromones; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Time Factors | 2000 |
Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent.
Topics: Cell Cycle; Cell Division; Chromones; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Morpholines; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Tumor Cells, Cultured | 2000 |
Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromones; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Excitatory Amino Acid Antagonists; Flavonoids; Fulvestrant; Glutamic Acid; Morpholines; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley | 2000 |
Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.
Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Cell Differentiation; Chromones; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Humans; Immediate-Early Proteins; Intracellular Signaling Peptides and Proteins; Isoenzymes; Mitogen-Activated Protein Kinases; Morpholines; Mutation; Nerve Growth Factor; Neuroblastoma; Phospholipase C gamma; Phosphorylation; ras Proteins; Receptor, trkA; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured; Type C Phospholipases | 2000 |
The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X.
Topics: Animals; Apoptosis; bcl-X Protein; Benzamides; Caspase 3; Caspases; Cell Count; Cell Division; Chromones; Cytochrome c Group; Cytosol; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Flavonoids; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Glycoproteins; Morpholines; Piperazines; Poly(ADP-ribose) Polymerases; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Tumor Cells, Cultured; Tyrphostins | 2000 |
Signalling pathways of insulin-like growth factor-I that are augmented by cAMP in FRTL-5 cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bucladesine; Cell Line; Chromones; Cyclic AMP; Enzyme Inhibitors; Flavonoids; GRB2 Adaptor Protein; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Rats; Receptor, Insulin; Signal Transduction; src Homology Domains; Thyroid Gland; Thyrotropin | 2000 |
Characterization of hepatocyte-derived mitogenic activity on hepatic stellate cells.
Topics: Animals; Cattle; Cell Separation; Cells, Cultured; Chromones; Culture Media, Conditioned; DNA; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Flavonoids; Hot Temperature; Insulin-Like Growth Factor I; Liver; Male; Mitogens; Mitosis; Molecular Weight; Morpholines; Peptide Fragments; Protein Precursors; Proteins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2000 |
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt.
Topics: Adenoviridae; Androstadienes; CCAAT-Enhancer-Binding Proteins; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Estrogen Antagonists; Flavonoids; Gene Expression Regulation; Genetic Vectors; Hepatocytes; Immunoblotting; Insulin; Liver; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Recombinant Fusion Proteins; Recombinant Proteins; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Tamoxifen; Time Factors; Transcription Factors; Transduction, Genetic; Wortmannin | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Anchorage-independent activation of mitogen-activated protein kinase through phosphatidylinositol-3 kinase by insulin-like growth factor I.
Topics: Breast Neoplasms; Cell Adhesion; Chromones; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2000 |
Inhibitors of tyrosine kinase signaling cascade attenuated antigen challenge of guinea-pig airways in vitro.
Topics: Animals; Antigens; Bronchoconstriction; Chromones; Enzyme Inhibitors; Flavonoids; Guinea Pigs; In Vitro Techniques; Lung; Male; Morpholines; Protein-Tyrosine Kinases | 2000 |
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
Topics: Adrenergic alpha-Agonists; Androstadienes; Cell Cycle; Chemotaxis; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras.
Topics: Androstadienes; Animals; Cell Differentiation; Cell Survival; Cell Transformation, Neoplastic; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Insulin Receptor Substrate Proteins; MAP Kinase Kinase Kinase 1; Mice; Mice, Nude; Morpholines; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Serine-Threonine Kinases; Rabbits; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.
Topics: Animals; Blotting, Western; Cell Survival; Chromones; Culture Media, Serum-Free; DNA Fragmentation; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor Receptors; In Situ Nick-End Labeling; Ligands; MAP Kinase Signaling System; Morpholines; Multiple Endocrine Neoplasia Type 2a; PC12 Cells; Phosphatidylinositol 3-Kinases; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 2000 |
Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity.
Topics: Apoptosis; Cell Hypoxia; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines | 2000 |
The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Division; Cell Line; Cell Survival; Chromones; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cysteine Proteinase Inhibitors; Cytochrome c Group; Cytosol; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Activation; Enzyme Inhibitors; Epithelium; Fibroblasts; Flavonoids; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Intestinal Mucosa; Isoquinolines; Microscopy, Fluorescence; Mitochondria; Morpholines; Peptides; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Sulfonamides; Time Factors; Transfection | 2000 |
Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways.
Topics: Apoptosis; Blotting, Western; Cell Survival; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-5; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Stem Cell Factor; Tumor Cells, Cultured | 2000 |
Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/AKT sensitivity.
Topics: Aminoisobutyric Acids; Animals; Blotting, Northern; Cattle; Cells, Cultured; Chromones; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Insulin-Like Growth Factor Binding Protein 3; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Somatomedins | 2000 |
Erk and PI-3 kinase are necessary for collagen binding and actin reorganization in corneal epithelia.
Topics: Actins; Animals; Blotting, Western; Chick Embryo; Chromones; Collagen; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelium, Corneal; Extracellular Matrix; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Signal Transduction | 2000 |
Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cell Differentiation; Cell Survival; Cells, Cultured; Chromatography, Affinity; Chromones; Colforsin; Dose-Response Relationship, Drug; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Ganglia, Spinal; Immunohistochemistry; Luciferases; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-raf; rap1 GTP-Binding Proteins; ras Proteins; Rats; Receptor, trkA; Signal Transduction; Time Factors; Transfection | 2000 |
Modulation of heart fibroblast migration and collagen gel contraction by IGF-I.
Topics: Animals; Animals, Newborn; Antigens, CD; Cell Adhesion; Cell Movement; Chromones; Collagen; Enzyme Inhibitors; Extracellular Matrix; Female; Fibroblasts; Flavonoids; Gels; Insulin-Like Growth Factor I; Integrin alphaV; Integrin beta1; Matrix Metalloproteinases; Morpholines; Myocardium; Pregnancy; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Vitronectin; Signal Transduction | 2000 |
Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age.
Topics: Aging; Amino Acids; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Leucine; Male; Morpholines; Muscle Proteins; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Sirolimus | 2000 |
Erythropoietin induction of tissue inhibitors of metalloproteinase-1 expression and secretion is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways.
Topics: Butadienes; CD36 Antigens; Chromones; Cycloheximide; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Erythropoietin; Flavonoids; Gene Expression Regulation; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured | 2000 |
Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromones; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Intestinal Mucosa; Mitogen-Activated Protein Kinases; Morpholines; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Receptor, IGF Type 1; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells.
Topics: Agar; Animals; Cell Cycle; Cell Division; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, Dominant; Hemangiosarcoma; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phenotype; Signal Transduction; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 2000 |
The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase.
Topics: Apoptosis; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Morpholines; Myocardium; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Signal Transduction; Virulence Factors, Bordetella | 2000 |
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia.
Topics: Animals; Base Sequence; Cell Line, Transformed; Chromones; DNA; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Glucose Transporter Type 1; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Monosaccharide Transport Proteins; Morpholines; Nuclear Proteins; Oncogene Protein p21(ras); Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Binding; Rats; RNA, Messenger; Transcription Factors | 2001 |
Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Division; Cells, Cultured; Chromones; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Heterotrimeric GTP-Binding Proteins; Humans; Insulin-Like Growth Factor II; Intestinal Mucosa; MAP Kinase Signaling System; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, IGF Type 1; Recombinant Proteins; Time Factors; Virulence Factors, Bordetella | 2001 |
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Hypertonic Solutions; I-kappa B Kinase; Imidazoles; Inflammation; Insulin-Like Growth Factor I; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandins A; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Stress, Physiological; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.
Topics: 3T3 Cells; Animals; Apoptosis; Chromones; Cytoprotection; Enzyme Activation; Flavonoids; Hepatocyte Growth Factor; Humans; Ligands; MAP Kinase Signaling System; Mice; Morpholines; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Transfection; Tumor Cells, Cultured | 2001 |
Insulin inhibits glucocorticoid-stimulated L-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by activation of the c-Jun N-terminal kinase pathway.
Topics: Animals; Chromones; Dexamethasone; Enzyme Inhibitors; Flavonoids; Fructose-Bisphosphatase; Gene Expression Regulation; Insulin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; Multienzyme Complexes; Phosphofructokinase-1; Phosphofructokinase-2; Plasmids; Rats; RNA, Messenger; Signal Transduction; Sirolimus; Transfection; Tumor Cells, Cultured | 2001 |
Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Apoptosis; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sirolimus; Wortmannin | 2001 |
Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Caspase 9; Caspases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; T-Lymphocytes; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Developmental expression of retinal cone cGMP-gated channels: evidence for rapid turnover and trophic regulation.
Topics: Animals; Cell Differentiation; Cell Extracts; Cell Survival; Cells, Cultured; Chick Embryo; Chromones; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Developmental; Ion Channel Gating; Ion Channels; MAP Kinase Signaling System; Morpholines; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Retina; Retinal Cone Photoreceptor Cells; RNA, Messenger | 2001 |
CNTFR alpha alone or in combination with CNTF promotes macrophage chemotaxis in vitro.
Topics: Androstadienes; Animals; Antigens, CD; Chemotactic Factors; Chemotaxis; Chromones; Ciliary Neurotrophic Factor; Cytokine Receptor gp130; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Growth Inhibitors; Humans; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Macrophages, Peritoneal; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Subunits; Receptor, Ciliary Neurotrophic Factor; Recombinant Proteins; Wortmannin | 2000 |
Involvement of both phosphatidylinositol 3-kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocytes; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyruvate Kinase; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 2001 |
Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Apoptosis; Cell Line; Cell Survival; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hematopoietic Stem Cells; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2001 |
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction | 2000 |
Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Adrenergic beta-Agonists; Animals; Blood Glucose; Cell Membrane; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Nonesterified; Flavonoids; Glucose Transporter Type 4; Glycerol; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Lipolysis; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Morpholines; Muscle Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Thiazoles; Tumor Necrosis Factor-alpha | 2001 |
Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Chloromethyl Ketones; Amino Acid Substitution; Animals; Apoptosis; Caspase 3; Caspases; Chromones; Coumarins; Cysteine Proteinase Inhibitors; Dopamine Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Flavonoids; Genes, Dominant; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Mutagenesis, Site-Directed; Neoplasm Proteins; Nerve Growth Factor; Oligopeptides; Parkinson Disease; Parkinsonian Disorders; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2001 |
Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Differentiation; Cell Division; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Morpholines; Neurites; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured | 2000 |
Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Division; Cells, Cultured; Chromones; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinases; Morpholines; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Recombinant Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
Synergistic activation of RSK correlates with c-fos induction in MO7e cells stimulated with GM-CSF plus Steel factor.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, fos; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; Stem Cell Factor; Time Factors; Transcriptional Activation | 2001 |
Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase.
Topics: Age Factors; Animals; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Ganglia, Spinal; Insulin-Like Growth Factor I; Isoenzymes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nerve Growth Factor; Neurites; Neurons, Afferent; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Rats; Rats, Sprague-Dawley; Type C Phospholipases | 2001 |
Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase.
Topics: Benzoquinones; Breast Neoplasms; Cell Movement; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Quinones; Receptor, IGF Type 1; Receptors, Estrogen; Rifabutin; RNA, Messenger; Stimulation, Chemical; Transcription Factor AP-1; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator | 2001 |
IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways.
Topics: Animals; Cell Division; Cells, Cultured; Chromones; Embryo, Nonmammalian; Flavonoids; Humans; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Receptor, IGF Type 1; Receptor, IGF Type 2; Recombinant Proteins; Salmon; Signal Transduction; Zebrafish | 2001 |
Signal transduction pathways involved in soluble fractalkine-induced monocytic cell adhesion.
Topics: Cell Adhesion; Chemokine CX3CL1; Chemokines, CX3C; Chemokines, CXC; Cholera Toxin; Chromones; CX3C Chemokine Receptor 1; Enzyme Inhibitors; Enzyme Precursors; Fibronectins; Flavonoids; GTP-Binding Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyridines; Receptors, Cytokine; Receptors, HIV; Signal Transduction; Syk Kinase; Virulence Factors, Bordetella | 2001 |
Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition.
Topics: Apoptosis; Chromones; Deoxycytidine; Enzyme Inhibitors; Flavonoids; Gemcitabine; Humans; Morpholines; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptor Protein-Tyrosine Kinases; Tumor Cells, Cultured | 2001 |
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
Topics: Animals; Binding Sites; Cell Hypoxia; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Genistein; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mammals; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Pyridines; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha 2 expression that is involved in cell scattering.
Topics: Animals; Antigens, CD; Cell Adhesion; Cell Line; Cell Movement; Chromones; Cycloheximide; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Humans; Integrin alpha2; Integrins; Kidney; Kinetics; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Receptors, Collagen; Recombinant Proteins; Tetradecanoylphorbol Acetate | 2001 |
p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades.
Topics: Cell Survival; Chromones; DNA Damage; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Morpholines; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Suppressor Protein p53 | 2001 |
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
Topics: Androstadienes; Benzoquinones; Blotting, Western; Cell Division; Cells, Cultured; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Indoles; Lactams, Macrocyclic; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Isoforms; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rifabutin; Thrombin; Time Factors; Trachea; Transfection; Virulence Factors, Bordetella; Wortmannin | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Apoptosis; CDC2-CDC28 Kinases; Chromones; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; ErbB Receptors; Fibroblast Growth Factor 2; Flavonoids; G1 Phase; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Tumor Cells, Cultured | 2001 |
Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Colforsin; Flavonoids; Humans; In Vitro Techniques; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin | 2001 |
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.
Topics: Animals; Animals, Newborn; Bacterial Outer Membrane Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Immediate-Early Proteins; Immunoblotting; Lipoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; Neurons; PC12 Cells; Phosphotransferases; Plasmids; Protein Binding; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors; Transfection | 2001 |
Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blood Cells; Cell Division; Cell Line; Cell Nucleus; Chromones; Enzyme Inhibitors; Flavonoids; GRB2 Adaptor Protein; Interleukin-3; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Sequence Deletion | 2001 |
Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Insulin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Morpholines; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Ultraviolet Rays | 2001 |
Pertussis toxin activates tyrosine kinase signaling cascade in myelomonocytic cells: a mechanism for cell adhesion.
Topics: Cell Adhesion; Chromones; Dimethyl Sulfoxide; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Kinetics; Lipopolysaccharide Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Transforming Growth Factor beta; Tyrphostins; U937 Cells; Virulence Factors, Bordetella | 2001 |
The Ras radiation resistance pathway.
Topics: Animals; Chromones; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genes, ras; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Radiation Tolerance; ras Proteins; Rats; Tumor Cells, Cultured | 2001 |
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins | 2001 |
Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.
Topics: Androstadienes; Apoptosis; Chemotaxis, Leukocyte; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leukotriene B4; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Virulence Factors, Bordetella; Wortmannin | 2001 |
Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Blood Platelets; Chromones; Cytoplasmic Granules; Enzyme Inhibitors; Flavonoids; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Platelet Aggregation; Protein Serine-Threonine Kinases; Thrombin; Thrombopoietin; Wortmannin | 2001 |
Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells.
Topics: Animals; Cell Differentiation; Cell Survival; Chromones; Drosophila Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; MAP Kinase Signaling System; Morpholines; Nerve Growth Factors; Nerve Tissue Proteins; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Transfection | 2001 |
Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carcinogens; Carrier Proteins; Chromones; Electrophoresis, Gel, Two-Dimensional; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hypertrophy; Insulin; Intracellular Signaling Peptides and Proteins; Morpholines; Myocardium; Oxidative Stress; Peptide Initiation Factors; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways.
Topics: Androstadienes; Animals; Cell Adhesion Molecules; Cell Line; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Fucose; Gene Expression Regulation; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kinetics; Ligands; Lipoproteins, LDL; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polysaccharides; Pyridines; Receptors, Immunologic; Receptors, Scavenger; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways.
Topics: Animals; Bass; Chromones; Flavonoids; Growth Hormone; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prolactin; Signal Transduction; Sirolimus | 2001 |
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoquinones; Cell Differentiation; Chromones; Cyclic AMP; Enzyme Inhibitors; Flavonoids; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Indoles; Isoproterenol; Isoquinolines; Lactams, Macrocyclic; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sirolimus; Sulfonamides; Tumor Cells, Cultured; Wortmannin | 2001 |
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.
Topics: 5' Untranslated Regions; Amyloid beta-Protein Precursor; Astrocytoma; Cell Survival; Chloramphenicol O-Acetyltransferase; Cholinesterase Inhibitors; Chromones; Culture Media, Conditioned; Drug Design; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Interleukin-1; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinases; Morpholines; Neuroblastoma; Phosphatidylinositol 3-Kinases; Physostigmine; Protein Biosynthesis; Recombinant Proteins; RNA, Messenger; Transfection; Tumor Cells, Cultured | 2001 |
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.
Topics: Adenosine; Androstadienes; Animals; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Receptor, Adenosine A3; Receptors, Purinergic P1; Recombinant Fusion Proteins; Wortmannin | 2001 |
Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.
Topics: Androstadienes; Animals; Apoptosis; Caspase 3; Caspases; Cattle; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Insulin-Like Growth Factor I; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Retina; Transfection; Wortmannin | 2001 |
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells.
Topics: Androstadienes; Butadienes; Chromones; Enzyme Inhibitors; Female; Fibronectins; Flavonoids; Humans; Indoles; Maleimides; MAP Kinase Kinase 1; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neoplasm Invasiveness; Nitriles; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured; Wortmannin | 2000 |
Erythropoietin activates two distinct signaling pathways required for the initiation and the elongation of c-myc.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Erythropoietin; Exons; Flavonoids; Humans; Isoenzymes; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Up-Regulation | 2001 |
Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.
Topics: Amino Acids; Animals; Astrocytes; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chromones; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Glycine; Immunoblotting; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes.
Topics: Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Growth Hormone; Hepatocytes; Insulin-Like Growth Factor I; Male; Mitogen-Activated Protein Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Somatotropin; Signal Transduction | 2001 |
Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2-Associated X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Cells, Cultured; Chromones; Colony-Forming Units Assay; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoietin; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Isoenzymes; Lithium Chloride; MAP Kinase Kinase 1; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Stem Cell Factor | 2001 |
Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Brain; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Insulin; MAP Kinase Signaling System; Methionine; Morpholines; Neurons; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Biosynthesis; Rats; Signal Transduction; Sirolimus; Time Factors; Up-Regulation | 2001 |
Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry.
Topics: Androstadienes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apigenin; Blood Proteins; Butadienes; Cell Division; Chickens; Chromones; Enzyme Inhibitors; Flavonoids; Hair Cells, Auditory; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Regeneration; Ribosomal Protein S6 Kinases; S Phase; Sirolimus; Wortmannin | 2001 |
p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chemotactic Factors; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Morpholines; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Wortmannin | 2001 |
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin | 2001 |
Phosphatidylinositol 3-kinase and ERK are required for NF-kappaB activation but not for phagocytosis.
Topics: Actin Cytoskeleton; Actins; Androstadienes; Cell Line; Chromones; Cytochalasin B; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Humans; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; NF-kappa B; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, IgG; Signal Transduction; Transcription, Genetic; Wortmannin | 2001 |
Quercetin abrogates taxol-mediated signaling by inhibiting multiple kinases.
Topics: Antioxidants; Apoptosis; Cell Cycle; Cell Division; Chromones; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; HeLa Cells; Humans; Imidazoles; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quercetin; Signal Transduction; Tumor Cells, Cultured | 2001 |
Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Caspases; Cell Survival; Cells, Cultured; Ceramides; Chromones; Enzyme Inhibitors; Flavonoids; GRB2 Adaptor Protein; Humans; Interleukin-1; MAP Kinase Kinase 1; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Osteoclasts; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha | 2001 |
Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carbazoles; Chromones; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Hemocytes; HSP70 Heat-Shock Proteins; Indoles; Isoproterenol; Isoquinolines; Luciferases; Morpholines; Naphthalenes; Norepinephrine; Ostreidae; Pertussis Toxin; Phenylephrine; Phosphodiesterase Inhibitors; Prazosin; Promoter Regions, Genetic; Propranolol; Pyrrolidinones; Signal Transduction; Sulfonamides; Transfection; Virulence Factors, Bordetella | 2001 |
Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Receptor, Endothelin A; Receptors, Endothelin; src Homology Domains; src-Family Kinases; Time Factors; Tyrosine; Wortmannin | 2001 |
Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line.
Topics: Androstadienes; Animals; Apoptosis; Bacterial Toxins; Butadienes; Cell Line; Chromones; DNA; Enterotoxins; Enzyme Inhibitors; Flavonoids; Hepatocytes; Humans; Lysophospholipids; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities.
Topics: Aging; Animals; Cell Survival; Cells, Cultured; Chromones; Drug Synergism; Energy Intake; Enzyme Inhibitors; Flavonoids; Hepatocytes; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Oxidants; Oxidative Stress; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats | 2002 |
Simultaneous signalling through c-mpl, c-kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC and MAPK pathways.
Topics: Cell Cycle Proteins; Cell Differentiation; Cell Division; Chromones; Drug Synergism; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Heat-Shock Proteins; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Megakaryocytes; Microfilament Proteins; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptors, CXCR4; Receptors, Cytokine; Receptors, Thrombopoietin; Schizosaccharomyces pombe Proteins; Signal Transduction; Stem Cell Factor; Stem Cells; Stimulation, Chemical; Thrombopoietin | 2001 |
Phosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activity.
Topics: Animals; Chromones; Enzyme Inhibitors; Female; Flavonoids; Germinal Center; In Vitro Techniques; Insulin; Kinetics; Mitogen-Activated Protein Kinases; Morpholines; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Progesterone; Recombinant Fusion Proteins; Substrate Specificity; Xenopus | 2001 |
IL-1alpha stimulation of osteoclast survival through the PI 3-kinase/Akt and ERK pathways.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chromones; Flavonoids; Interleukin-1; Mice; Mitogen-Activated Protein Kinases; Morpholines; Osteoclasts; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2002 |
Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells.
Topics: Adenocarcinoma; Apoptosis; Autocrine Communication; Cell Cycle; Chromones; Colonic Neoplasms; Culture Media; Culture Media, Serum-Free; Dimerization; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Growth Substances; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Neuregulin-1; Neutralization Tests; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Signal Transduction; Sirolimus; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2002 |
The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation.
Topics: Animals; Carrier Proteins; Cell Differentiation; Cell Line; Chromones; Coculture Techniques; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Macrophage Colony-Stimulating Factor; MAP Kinase Kinase 1; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Osteoblasts; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Stem Cells | 2002 |
The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Chromones; DNA-Binding Proteins; Fibroblasts; Flavonoids; Genes, Dominant; GTP Phosphohydrolases; MAP Kinase Signaling System; Mice; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Repressor Proteins; Sirolimus; STAT3 Transcription Factor; Trans-Activators | 2002 |
Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts.
Topics: Actin Cytoskeleton; Amides; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Chromones; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Oncogene Protein p21(ras); Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Transcription, Genetic; Transfection | 2002 |
Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Cell Membrane; Cell Survival; Cells, Cultured; Chromones; Down-Regulation; Embryonic and Fetal Development; Enzyme Inhibitors; Fetus; Fibroblasts; Flavonoids; Intracellular Membranes; Lipid Metabolism; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA, Messenger; Time Factors | 2002 |
Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Division; Cell Line; Cell Line, Transformed; Cell Size; Cell Transformation, Viral; Chromones; Colony-Forming Units Assay; Enzyme Activation; Enzyme Inhibitors; Flavonoids; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morpholines; Oncogene Proteins, Viral; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras) | 2002 |
Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.
Topics: Animals; Carrier Proteins; Cell Line; Chromones; Curcumin; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation; Genes, Dominant; Imidazoles; Interleukin-1; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Naphthalenes; Oxygen; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyridines; rac1 GTP-Binding Protein; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection | 2002 |
Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Breast Neoplasms; Cell Survival; Chromones; Cyclic AMP-Dependent Protein Kinases; Electrophoretic Mobility Shift Assay; ErbB Receptors; Flavonoids; Gene Expression Regulation, Neoplastic; I-kappa B Kinase; Mice; Mice, Transgenic; Morpholines; Neuregulin-1; NF-kappa B; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Receptor, ErbB-2; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells.
Topics: Chromones; Colorectal Neoplasms; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HT29 Cells; Humans; Immunohistochemistry; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Zinc | 2002 |
Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes.
Topics: Adolescent; Cells, Cultured; Chromones; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Kinetics; Lysophospholipids; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrones; Sphingosine; Transcription Factors | 2002 |
Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Male; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Rats; Rats, Sprague-Dawley | 2002 |
IGF-1 regulates migration and angiogenesis of human endothelial cells.
Topics: Androstadienes; Cell Movement; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glucose; Humans; Insulin-Like Growth Factor I; Morpholines; Neovascularization, Physiologic; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Chromones; Cyclin D1; DNA Replication; Enzyme Inhibitors; Flavonoids; Guinea Pigs; Male; MAP Kinase Signaling System; Morpholines; Muscle, Smooth; Protein-Tyrosine Kinases; Respiratory Physiological Phenomena; Thrombin; Thymidine | 2002 |
PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Ischemic Preconditioning; Male; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Wortmannin | 2002 |
Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chromones; Cystic Fibrosis; Enzyme Inhibitors; Flavonoids; JNK Mitogen-Activated Protein Kinases; Macrophages; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Pneumonia; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sodium Chloride; Tumor Necrosis Factor-alpha | 2002 |
Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization.
Topics: Albuterol; Basophils; Calcimycin; Calcium Channel Blockers; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Histamine Release; Humans; Imidazoles; Immunoglobulin E; Interleukin-13; Interleukin-4; Interleukins; Leukotriene C4; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Salmeterol Xinafoate; Second Messenger Systems; Theophylline | 2002 |
Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Animals; Cell Culture Techniques; Chick Embryo; Chromones; Electrophysiology; Enzyme Inhibitors; Flavonoids; Immunoblotting; Immunohistochemistry; Large-Conductance Calcium-Activated Potassium Channels; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channels, Calcium-Activated; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transforming Growth Factor beta; Wortmannin | 2002 |
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.
Topics: Androstadienes; Antineoplastic Agents; Benzamides; Caspase 3; Caspases; Chromones; Drug Synergism; Enzyme Inhibitors; Flavonoids; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Pyrimidines; Reference Values; Tumor Cells, Cultured; Wortmannin | 2002 |
Insulin-like growth factor-I inhibits cell growth in the a549 non-small lung cancer cell line.
Topics: Adenocarcinoma; Apoptosis; Cell Division; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Lung Neoplasms; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Tumor Cells, Cultured | 2002 |
Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).
Topics: Antibiotics, Antineoplastic; Blotting, Western; Butadienes; Cell Cycle; Cell Division; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Humans; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Multiple Myeloma; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2002 |
Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway.
Topics: alpha-Synuclein; Animals; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Morpholines; Nerve Tissue Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; RNA, Messenger; Signal Transduction; Synucleins; Time Factors; Tumor Cells, Cultured | 2002 |
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells.
Topics: Adult; Antigens, CD34; Antigens, Differentiation; Butadienes; Carbazoles; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Flavonoids; Glycophorins; Hematopoietic Stem Cells; Humans; Indoles; Isoenzymes; Morpholines; Naphthalenes; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Staurosporine; Stem Cell Factor | 2002 |
Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.
Topics: Alkaloids; Azepines; Blotting, Western; Calcium; Carbazoles; Cell Division; Cell Movement; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Indoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microcirculation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Pathologic; Nitric Oxide; Nitrites; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Receptor, EphB4; Signal Transduction; Time Factors | 2002 |
Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death.
Topics: Animals; Cell Death; Cell Line; Chromones; Culture Media, Serum-Free; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Islets of Langerhans; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats | 2002 |
Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts.
Topics: Activin Receptors, Type I; Cells, Cultured; Chromones; Collagen Type I; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Morpholines; Naphthalenes; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Scleroderma, Systemic; Skin; Transcription, Genetic; Up-Regulation | 2002 |
Neuritogenesis induced by thyroid hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase-phosphatidylinositol 3-kinase pathways and involves modulation of extracellular matrix proteins.
Topics: Animals; Astrocytes; Cells, Cultured; Chromones; Coculture Techniques; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Matrix; Fibronectins; Flavonoids; Immunohistochemistry; Laminin; Models, Biological; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Protein Binding; Rats; Rats, Wistar; Signal Transduction; Time Factors; Triiodothyronine | 2002 |
Novel activities of pro-IGF-I E peptides: regulation of morphological differentiation and anchorage-independent growth in human neuroblastoma cells.
Topics: Biomarkers; Cell Differentiation; Cell Division; Cell Line; Cell Movement; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Insulin-Like Growth Factor I; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; Neurites; Neuroblastoma; Peptides; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Recombinant Proteins; Signal Transduction; Transfection; Tumor Cells, Cultured | 2002 |
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.
Topics: Androstadienes; Carcinoma, Squamous Cell; Caveolae; Caveolin 1; Caveolins; Cell Line; Chromones; Colchicine; Cyclodextrins; Cytochalasin D; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Kinetics; Morpholines; Nucleic Acid Synthesis Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; src-Family Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2002 |
Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.
Topics: Adenosine; Androstadienes; Arginine; Biological Transport; Butadienes; Calcium; Cells, Cultured; Chromones; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Fetus; Flavonoids; Gene Expression; Genistein; Humans; Hydrogen-Ion Concentration; MAP Kinase Signaling System; Membrane Potentials; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitriles; Phenethylamines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium; Protein Isoforms; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin | 2002 |
Salicylate suppresses macrophage nitric-oxide synthase-2 and cyclo-oxygenase-2 expression by inhibiting CCAAT/enhancer-binding protein-beta binding via a common signaling pathway.
Topics: Animals; Blotting, Western; Cell Line; Chromones; Cyclooxygenase 2; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Interferon-gamma; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Morpholines; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nuclear Proteins; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Salicylates; Signal Transduction; Time Factors; Trans-Activators; Transfection | 2002 |
Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway.
Topics: Adrenal Cortex; Animals; Capillaries; Cell Division; CHO Cells; Chromones; Cricetinae; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Factor 4; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2002 |
Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras.
Topics: Animals; Apoptosis; Chromones; Enzyme Inhibitors; fas Receptor; Flavonoids; Gene Expression Regulation, Neoplastic; Lymphoma; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; ras Proteins; Signal Transduction; Thymus Neoplasms; Tumor Cells, Cultured | 2002 |
4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.
Topics: 4-1BB Ligand; Animals; Antibodies, Monoclonal; Antigens, CD; Apoptosis; bcl-X Protein; CD8-Positive T-Lymphocytes; Cell Division; Cell Survival; Chromones; Flavonoids; Gene Expression Regulation; Ligands; Lymphocyte Activation; Male; MAP Kinase Kinase Kinase 1; Mice; Mice, Inbred BALB C; Minor Histocompatibility Antigens; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor Receptor Superfamily, Member 9; Tumor Necrosis Factor-alpha; Up-Regulation | 2002 |
Differential roles of SOCS family members in EpoR signal transduction.
Topics: Animals; Carrier Proteins; Cell Division; Chromones; DNA-Binding Proteins; Erythropoietin; Flavonoids; Gene Expression Regulation; Genes, Reporter; Hematopoietic Stem Cells; Immediate-Early Proteins; Mice; Milk Proteins; Morpholines; Phosphorylation; Protein Biosynthesis; Protein Processing, Post-Translational; Proteins; Receptors, Erythropoietin; Recombinant Fusion Proteins; Repressor Proteins; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors | 2002 |
The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation.
Topics: Arachidonic Acids; Butadienes; Cell Differentiation; Cell Division; Cell Line; Chemotaxis, Leukocyte; Chromones; Endocannabinoids; Enzyme Inhibitors; Flavonoids; Glycerides; Granulocyte Colony-Stimulating Factor; Humans; Interleukin-3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Oncogene Proteins; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Mas; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Signal Transduction | 2003 |
Embryonic testis cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathway.
Topics: Animals; Apoptosis; Cell Movement; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gestational Age; Male; Mesonephros; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pregnancy; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Seminiferous Tubules; Signal Transduction; Testis | 2002 |
Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes.
Topics: Androstadienes; Cell Survival; Chromones; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; In Vitro Techniques; Macrophage Colony-Stimulating Factor; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Reactive Oxygen Species; Wortmannin | 2002 |
Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Division; Cell Separation; Chromones; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Mitogen-Activated Protein Kinases; Morpholines; Piperidines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; S Phase; Signal Transduction; Time Factors; Transfection; Trastuzumab; Tumor Cells, Cultured | 2002 |
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Topics: Androstadienes; Animals; Apoptosis; Carcinoma; Chromones; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Laminin; Male; Mice; Mice, Nude; Morpholines; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured; Wortmannin | 2002 |
Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells.
Topics: Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; Imidazoles; Immunoassay; Immunoblotting; Indoles; Interleukin-1; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mucin-2; Mucins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors | 2002 |
Participation of various kinases in staurosporine induced apoptosis of RAW 264.7 cells.
Topics: Animals; Apoptosis; Caspases; Cell Line; Chromones; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Isoquinolines; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Staurosporine; Sulfonamides | 2002 |
Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase.
Topics: Animals; Capillaries; Cell Line; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hedgehog Proteins; Humans; Mice; Morphogenesis; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Trans-Activators | 2003 |
Downstream effectors of oncogenic ras in multiple myeloma cells.
Topics: Alkyl and Aryl Transferases; Cell Cycle; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Farnesyltranstransferase; Flavonoids; Genes, ras; I-kappa B Proteins; Interleukin-6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Multiple Myeloma; Neoplasm Proteins; NF-kappa B; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Trans-Activators; Transfection; Tumor Cells, Cultured | 2003 |
Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.
Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Rhabdomyosarcoma; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2003 |
Steroidogenic responses of pig corpora lutea to insulin-like growth factor I (IGF-I) throughout the oestrous cycle.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Corpus Luteum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrus; Female; Flavonoids; Follicular Phase; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Progesterone; Receptor, IGF Type 1; Signal Transduction; Sus scrofa; Wortmannin | 2003 |
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Topics: Amino Acid Substitution; Androstadienes; Animals; Carcinoma, Lewis Lung; Chromones; Collagen; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Insulin-Like Growth Factor I; Laminin; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Morpholines; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Point Mutation; Promoter Regions, Genetic; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptor, IGF Type 1; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2003 |
p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts.
Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cell Line; Chromones; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Signalling pathways involved in the short-term potentiation of dopamine release by BDNF.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Chromones; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Flavonoids; Humans; In Vitro Techniques; Indole Alkaloids; Membrane Glycoproteins; Morpholines; Phosphatidylinositol 3-Kinases; Potassium Chloride; Protein Biosynthesis; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Synaptosomes; Transcription, Genetic | 2003 |
Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells.
Topics: Alkaline Phosphatase; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Chromones; Enzyme Induction; Enzyme Inhibitors; Fetus; Flavonoids; Insulin-Like Growth Factor I; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Skull; Transforming Growth Factor beta | 2003 |
Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor.
Topics: Animals; Carcinoma, Lewis Lung; Chromones; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Insulin-Like Growth Factor I; Lymphatic Metastasis; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; RNA, Messenger; Signal Transduction; Vascular Endothelial Growth Factor C | 2003 |
Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells.
Topics: Butadienes; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Humans; Integrin alpha2; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2003 |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin | 2003 |
In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia.
Topics: Adult; Aged; Alkyl and Aryl Transferases; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Survival; Cells, Cultured; Chromones; Colony-Forming Units Assay; Enzyme Inhibitors; Erythrocyte Count; Farnesyltranstransferase; Female; Flavonoids; GPI-Linked Proteins; Hematopoietic Stem Cells; Humans; Male; Membrane Glycoproteins; Mesothelin; Middle Aged; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Polycythemia Vera; Primary Myelofibrosis; Proteins; Quinolones; Thrombocythemia, Essential | 2003 |
Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis.
Topics: Androstadienes; Animals; Biological Assay; Cell Division; Cells, Cultured; Chromones; Collagen; Drug Combinations; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Laminin; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Wortmannin | 2003 |
IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.
Topics: Bronchi; Bronchial Hyperreactivity; Butadienes; Cell Count; Cells, Cultured; Chromones; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Goblet Cells; Humans; Imidazoles; Interleukin-13; Interleukin-4; Ion Channels; MAP Kinase Signaling System; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines | 2003 |
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Nucleus; Chromones; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Luciferases; Melanoma; Membrane Glycoproteins; Milk Proteins; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; TNF-Related Apoptosis-Inducing Ligand; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Arachidonic Acids; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Dronabinol; Flavonoids; Gene Expression Regulation; Humans; Liver; Lymphocytes; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphorylation; Piperidines; Polymerase Chain Reaction; Prostate; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Spleen | 2003 |
Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.
Topics: Apoptosis; bcl-X Protein; Cell Division; Cell Line; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Leukemia; Ligands; Membrane Proteins; Morpholines; Mutation; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Prognosis; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Time Factors; Transfection | 2003 |
IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.
Topics: Androstadienes; Anilides; Animals; Annexin A5; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cell Survival; Chromones; Culture Media, Serum-Free; Flavonoids; Flow Cytometry; Humans; Imidazoline Receptors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Morpholines; Oligopeptides; PC12 Cells; Proteins; Rats; Staurosporine; Thapsigargin; Transfection; Wortmannin | 2003 |
Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase.
Topics: Angiogenesis Inducing Agents; Animals; Cell Line; Cell Movement; Chromones; Cornea; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Humans; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutation; Neovascularization, Physiologic; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Signal Transduction; Transcription Factors | 2003 |
Insulin-like growth factor I promotes maturation and inhibits apoptosis of immature cord blood monocyte-derived dendritic cells through MEK and PI 3-kinase pathways.
Topics: Apoptosis; Cell Differentiation; Cell Division; Chromones; Dendritic Cells; Enzyme Inhibitors; Fetal Blood; Flavonoids; Humans; Infant, Newborn; Insulin-Like Growth Factor I; Lymphocytes; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tumor Necrosis Factor-alpha | 2003 |
The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chlorocebus aethiops; Chromones; COS Cells; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factors; Flavonoids; Gene Expression Regulation; Membrane Glycoproteins; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptor, Fibroblast Growth Factor, Type 3; Receptors, Fibroblast Growth Factor; Retroviridae; Signal Transduction | 2003 |
Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway.
Topics: Antibiotics, Antineoplastic; Apoptosis; Biotin; Caspase 9; Caspases; Cell Line; Cell Line, Tumor; Cell Membrane; Chromones; DNA Fragmentation; Down-Regulation; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Humans; Immunoblotting; Inositol; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Recombinant Proteins; Serine; Signal Transduction; Threonine; Time Factors | 2004 |
IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.
Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin | 2003 |
1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes.
Topics: Animals; Blotting, Western; Butadienes; Cell-Free System; Chromones; Colforsin; Cycloheximide; Enzyme Inhibitors; Female; Flavonoids; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Pentetic Acid; Phenanthrolines; Phosphorylation; Progesterone; Threonine; Tyrosine; Xenopus laevis; Zinc Sulfate | 2003 |
IGF-1 induces growth, survival and morphological change of primary hepatocytes on a galactose-bared polymer through both MAPK and beta-catenin pathways.
Topics: Animals; Asialoglycoprotein Receptor; beta Catenin; Cell Division; Cell Size; Cell Survival; Cells, Cultured; Chromones; Cytoskeletal Proteins; DNA Replication; Enzyme Inhibitors; Flavonoids; Hepatocytes; Insulin-Like Growth Factor I; Lactose; Male; MAP Kinase Signaling System; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polystyrenes; Signal Transduction; Trans-Activators | 2003 |
Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chromones; Cycloheximide; Depression, Chemical; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Liver; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; RNA, Messenger; Sequence Alignment; Signal Transduction | 2003 |
Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines.
Topics: Aorta; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokines; Chemotaxis; Chromones; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-8; Lysophosphatidylcholines; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyridines; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Umbilical Veins | 2003 |
Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Cytokines; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; Janus Kinase 1; Male; MAP Kinase Signaling System; Morpholines; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Biosynthesis; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Tyrphostins | 2003 |
Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin | 2003 |
Erythropoietin promotes resistance against the Abl tyrosine kinase inhibitor imatinib (STI571) in K562 human leukemia cells.
Topics: Apoptosis; Benzamides; Cell Division; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Erythropoietin; Flavonoids; Fusion Proteins, bcr-abl; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imatinib Mesylate; Interleukin-3; K562 Cells; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Stem Cell Factor; Time Factors | 2003 |
The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells.
Topics: 2-Methoxyestradiol; Apoptosis; Arabidopsis Proteins; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Chromones; Death Domain Receptor Signaling Adaptor Proteins; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Estradiol; fas Receptor; Fatty Acid Desaturases; Flavonoids; Genes, Dominant; Humans; I-kappa B Proteins; Intracellular Signaling Peptides and Proteins; Luciferases; Male; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Organic Chemicals; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor; Signal Transduction; Sulfones; Tumor Cells, Cultured | 2004 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; Cell Movement; Chromones; Culture Media, Conditioned; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glioblastoma; Humans; Matrix Metalloproteinase Inhibitors; Mice; Mice, Nude; Morpholines; Neoplasms; Neovascularization, Pathologic; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A | 2004 |
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.
Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins | 2003 |
Epidermal growth factor suppresses interferon-induced accumulation of p53 and p21 by using protein kinase C.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Indoles; Interferon-alpha; Interferon-gamma; Interferons; Maleimides; Morpholines; Protein Kinase C; Tumor Suppressor Protein p53 | 2003 |
Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Annexin A5; Apoptosis; Blotting, Western; Carrier Proteins; Caspases; Cell Line, Tumor; Cell Survival; Chromones; Cycloheximide; DNA Fragmentation; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; Lung Neoplasms; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction | 2004 |
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
Topics: Androstadienes; Animals; Blotting, Western; Carcinoma, Lewis Lung; Cell Line, Tumor; Chloramphenicol O-Acetyltransferase; Chromones; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Gene Expression Regulation, Enzymologic; Genes, Dominant; Genes, Reporter; Insulin-Like Growth Factor I; Matrix Metalloproteinase 2; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Plasmids; Proto-Oncogene Proteins c-raf; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sirolimus; Time Factors; Tumor Suppressor Proteins; Wortmannin | 2004 |
Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells.
Topics: Benzoquinones; Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dental Pulp; Dexamethasone; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Signal Transduction; Sulfonamides | 2004 |
Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism.
Topics: Animals; Cell Line; Chromones; Cytoplasm; Drug Synergism; Enzyme Inhibitors; Erythropoietin; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, Erythropoietin; Recombinant Proteins; Serine | 2004 |
Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1.
Topics: Apoptosis; CD11 Antigens; CD11b Antigen; Cell Cycle; Cell Division; Cell Survival; Chromones; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavonoids; Humans; Hydantoins; Imidazoles; Macrophages; Morpholines; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Prostaglandin D2; Pyridines; Time Factors; Tumor Cells, Cultured | 2004 |
Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.
Topics: Animals; Cell Transformation, Neoplastic; Chromones; Enzyme Inhibitors; Epithelial Cells; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, ras; Mitogen-Activated Protein Kinases; Morpholines; Ovary; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-raf; Rats; Signal Transduction; Transcription, Genetic | 2004 |
Activation of the phosphatidylinositol-3' kinase pathway and DNA synthesis by a mutant insulin-like growth factor I receptor lacking the NPXY motif.
Topics: Amino Acid Motifs; Animals; Cell Line; Chromones; DNA; Enzyme Activation; Flavonoids; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Mice; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Receptor, IGF Type 1 | 2004 |
Guanosine protects SH-SY5Y cells against beta-amyloid-induced apoptosis.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amyloid beta-Peptides; Apoptosis; Blotting, Western; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Guanosine; Humans; Morpholines; Neuroblastoma; Neuroprotective Agents; Peptide Fragments; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Time Factors | 2004 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity.
Topics: Amino Acid Substitution; Apoptosis; Cell Line; Cell Survival; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase Kinase 5; Morpholines; Oncogene Protein p21(ras); Protein Binding; Protein Serine-Threonine Kinases; Recombinant Proteins; Signal Transduction; Transfection | 2004 |
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunohistochemistry; Laminin; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Pyridines; Serine; Signal Transduction; Transfection; Urinary Bladder Neoplasms | 2004 |
FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O3; Forkhead Transcription Factors; Hematopoietic Stem Cells; Humans; Ligands; Membrane Proteins; Mice; Mitogen-Activated Protein Kinases; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins; Recombinant Proteins; Retroviridae Proteins, Oncogenic; Signal Transduction; Transcription Factors; Tumor Suppressor Proteins; Up-Regulation | 2004 |
Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Cell Line; Chromones; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Insulin; Insulin Resistance; MAP Kinase Signaling System; Mice; Morpholines; Muscle, Skeletal; Muscles; Mutation; Phosphatidylinositol 3-Kinases; RNA; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Time Factors; Transcription Factors; Wortmannin | 2004 |
Stimulation of insulin-like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-alpha is mediated by both phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways in mammary epithelial cells.
Topics: Animals; Cattle; Cell Line; Chromones; DNA; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mammary Glands, Animal; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RNA, Messenger; Transforming Growth Factor alpha | 2004 |
Regulation of Na(+)-K(+)-2Cl- cotransporter activity in rat skeletal muscle and intestinal epithelial cells.
Topics: Animals; Bumetanide; Butadienes; Cell Line; Chromones; Colforsin; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gastrointestinal Tract; Indoles; Isoproterenol; Isoquinolines; Maleimides; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Skeletal; Nitriles; Potassium; Rats; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Sulfonamides | 2003 |
Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes.
Topics: Animals; Cell Division; Cells, Cultured; Chromones; Claudin-1; Connexins; DNA Replication; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gap Junction beta-1 Protein; Gap Junctions; Hepatocytes; Membrane Proteins; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Tight Junctions | 2004 |
RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Blotting, Western; Bone Marrow Cells; Carrier Proteins; Cathepsin K; Cathepsins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p19; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; Femur; Flavonoids; Gene Expression; Imidazoles; Isoenzymes; Macrophage Colony-Stimulating Factor; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Osteoclasts; Osteopetrosis; Pyridines; Radiography; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Tartrate-Resistant Acid Phosphatase; Tumor Suppressor Proteins | 2004 |
Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1.
Topics: Active Transport, Cell Nucleus; Animals; Astrocytes; Bradykinin; Cells, Cultured; Chromones; Flavonoids; Gene Expression Regulation; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Morpholines; NF-kappaB-Inducing Kinase; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction | 2004 |
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2004 |
[Mechanism of interleukin-1beta increasing growth hormone expression in rat pituitary GH3 cells].
Topics: Animals; Cell Line; Chromones; Flavonoids; Genes, Reporter; Growth Hormone; Humans; Interleukin-1; Luciferases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Gland; Rats; Signal Transduction | 2004 |
Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Ceramides; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glucosyltransferases; Humans; Interleukin-2; Killer Cells, Natural; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; RNA, Messenger; Sphingomyelin Phosphodiesterase; Transcription, Genetic; Transferases (Other Substituted Phosphate Groups); Tyrphostins | 2004 |
Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspases; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cycloheximide; DNA; DNA Replication; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Leptin; Liver; Membrane Glycoproteins; Mitogens; Mitosis; Morpholines; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, Leptin; Repressor Proteins; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Tumor Necrosis Factor-alpha | 2004 |
Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.
Topics: Animals; Anthracenes; Aorta; Cell Division; Cells, Cultured; Chromones; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Flavonoids; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice; Mice, Inbred C57BL; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Nitric Oxide; Organ Specificity; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protoporphyrins; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Simvastatin | 2004 |
Regulation of Gene33 expression by insulin requires MEK-ERK activation.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Immune Sera; Insulin; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Signal Transduction; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2004 |
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
Topics: Androstadienes; Animals; Anthracenes; Cell Line; Cell Movement; Cell Survival; Chemokine CCL4; Chemotaxis; Chromones; Complement C5a; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophage Inflammatory Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin | 2004 |
Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction.
Topics: Animals; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Gadolinium; Genistein; Indoles; Maleimides; Mechanoreceptors; Mechanotransduction, Cellular; Mice; Morpholines; Myoblasts, Skeletal; Paracrine Communication; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Stress, Mechanical; Tensile Strength | 2005 |
HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal-regulated kinase-dependent manner.
Topics: Apoptosis; bcl-X Protein; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Chromones; Dimerization; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Products, nef; Genes, Dominant; Granulocyte-Macrophage Colony-Stimulating Factor; Green Fluorescent Proteins; Humans; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Morpholines; Proto-Oncogene Proteins c-bcl-2; Ribonucleases; RNA; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes; Time Factors; Trans-Activators; Up-Regulation; Virus Replication | 2004 |
SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival.
Topics: Brain Neoplasms; Cell Line, Tumor; Chromones; Enzyme Activation; ErbB Receptors; Flavonoids; Glioblastoma; Humans; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Morpholines; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases | 2004 |
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.
Topics: Aldosterone; Androstadienes; Animals; Blotting, Western; Calcium; Chromones; Enzyme Inhibitors; Eplerenone; Flavonoids; Hydrogen-Ion Concentration; Indoles; Male; Maleimides; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Morpholines; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Time Factors; Vasoconstriction; Wortmannin | 2005 |
Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.
Topics: Animals; Axons; Carbazoles; Cell Survival; Chromones; Ciliary Neurotrophic Factor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Flavonoids; Indoles; MAP Kinase Signaling System; Morpholines; Nerve Regeneration; Optic Nerve Injuries; Peroneal Nerve; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Inbred F344; Receptor, Ciliary Neurotrophic Factor; Retinal Ganglion Cells; Signal Transduction; STAT3 Transcription Factor; Thionucleotides; Trans-Activators; Tyrphostins; Up-Regulation | 2004 |
Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Animals; Antibiotics, Antineoplastic; Aorta; Carrier Proteins; Cattle; Cell Division; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2005 |
Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.
Topics: Aorta, Abdominal; Becaplermin; Cell Division; Cell Movement; Cells, Cultured; Chromones; DNA Replication; Enzyme Activation; Fibroblast Growth Factor 2; Flavonoids; Heparin; Humans; Indoles; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Recombinant Proteins; RNA, Small Interfering; Tyrphostins | 2005 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Chemokines; Chromones; Cytokines; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-17; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Morpholines; NF-kappa B; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Wortmannin | 2005 |
Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways.
Topics: Alkaline Phosphatase; Animals; Aorta; Aortic Diseases; Becaplermin; Calcinosis; Calcium; Cattle; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; DNA-Binding Proteins; ets-Domain Protein Elk-1; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Insulin-Like Growth Factor I; Lipopolysaccharides; MAP Kinase Kinase Kinases; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha; Tunica Media | 2005 |
PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung.
Topics: Androstadienes; Animals; Apoptosis; Cell Survival; Chromones; Extracellular Signal-Regulated MAP Kinases; Fetal Development; Fibroblast Growth Factor 1; Flavonoids; Gene Expression Regulation, Developmental; In Situ Nick-End Labeling; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Wortmannin | 2005 |
Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin.
Topics: Androstadienes; Animals; Blotting, Western; Cell Movement; Cells, Cultured; Chromones; Flavonoids; Lysophospholipids; Morpholines; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Wortmannin | 2005 |
Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway.
Topics: Blotting, Western; Cell Line, Tumor; Choriocarcinoma; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Humans; Isoelectric Focusing; Morpholines; Osteopontin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases; Sialoglycoproteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2005 |
Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.
Topics: Animals; Apoptosis; Blotting, Western; Cell Adhesion; Cell Line; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibronectins; Fibrosis; Flavonoids; Flow Cytometry; Immunoprecipitation; Integrins; Ligands; MAP Kinase Signaling System; Mice; Microscopy, Confocal; Morpholines; Phosphatidylinositol 3-Kinases; Protein Binding; Signal Transduction; Staurosporine; Transfection | 2005 |
Insulin-like growth factor-I stimulated DNA replication in mouse endometrial stromal cells.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Chromones; DNA; DNA Replication; Endometrium; Enzyme Inhibitors; Estradiol; Female; Flavonoids; Gene Expression Regulation; Genistein; Insulin-Like Growth Factor I; Mice; Morpholines; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells | 2005 |
Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6.
Topics: Cell Differentiation; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Dominant; Goblet Cells; HT29 Cells; Humans; Intestines; MAP Kinase Kinase Kinases; Methotrexate; Morpholines; Mucin-2; Mucin-3; Mucins; Muscle Proteins; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Trefoil Factor-3 | 2005 |
Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstadienes; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Cell Differentiation; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HL-60 Cells; Humans; Indoles; Lactones; Maleimides; Models, Biological; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Wortmannin | 2005 |
NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation.
Topics: Apoptosis; Cell Line, Transformed; Cell Line, Tumor; Chromones; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Kinetics; Male; Morpholines; NF-kappa B; Prostatic Neoplasms; Radiation-Sensitizing Agents; Radiation, Ionizing | 2005 |
IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.
Topics: Cell Line, Transformed; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HSP90 Heat-Shock Proteins; Humans; Interleukin-2; Killer Cells, Natural; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocyte Activation; Macrolides; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; RNA-Directed DNA Polymerase; Sirolimus; Telomerase; TOR Serine-Threonine Kinases; Transcription, Genetic | 2005 |
Inhibition of different intracellular signal cascades in human pancreatic cancer cells.
Topics: Antibiotics, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Division; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Humans; Morpholines; Pancreatic Neoplasms; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2005 |
Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide.
Topics: Actins; Alanine; Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Cell Movement; Chemotaxis; Chromones; Cytoskeleton; Dose-Response Relationship, Drug; Flavonoids; Humans; Immunoprecipitation; Integrin alphaV; Integrin alphaVbeta3; Integrin beta4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Peptides; Phosphorylation; Protein Binding; Protein Kinase C; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Signal Transduction; Temperature; Time Factors; Vitronectin; Wortmannin | 2005 |
Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages.
Topics: Animals; Cell Line; Chromones; Cyclooxygenase 2; Endotoxemia; Flavonoids; Gene Expression Regulation; Genes, src; Lipopolysaccharides; Macrophage Activation; Macrophages; Macrophages, Peritoneal; Mice; Morpholines; NF-kappa B; Nitric Oxide; Peritonitis; Phosphoinositide-3 Kinase Inhibitors; Proline; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Thiocarbamates; Tumor Necrosis Factor-alpha | 2006 |
Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Movement; Cell Proliferation; Chemotaxis; Chromones; Differential Threshold; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; PC12 Cells; Pheochromocytoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction | 2005 |
Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes.
Topics: Amino Acid Transport Systems, Neutral; Animals; Binding, Competitive; Biological Transport; Biotinylation; Blotting, Northern; Cell Membrane; Chromones; COS Cells; Culture Media, Serum-Free; Diet; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Hepatocytes; Histidine; Humans; Immunoblotting; Immunoprecipitation; Insulin; Liver; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2005 |
Kainate mediates nuclear factor-kappa B activation in hippocampus via phosphatidylinositol-3 kinase and extracellular signal-regulated protein kinase.
Topics: Animals; Blotting, Western; Chromones; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Lamin Type B; Male; MAP Kinase Kinase Kinases; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2005 |
Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).
Topics: Animals; Benzylamines; Biphenyl Compounds; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Chromones; Diglycerides; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Female; Fetus; Flavonoids; Inositol 1,4,5-Trisphosphate; Lignans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Morpholines; Neurites; Neurons; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pregnancy; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides | 2005 |
Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms.
Topics: Animals; Cells, Cultured; Chromones; Dexamethasone; Dose-Response Relationship, Drug; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Like Growth Factor I; Lithium Chloride; MAP Kinase Signaling System; Models, Biological; Morpholines; Muscle Fibers, Skeletal; Muscle Proteins; Phosphatidylinositol 3-Kinases; Protein Kinases; Rats; Sirolimus; Thiadiazoles; TOR Serine-Threonine Kinases | 2005 |
Direct activation of telomerase by GH via phosphatidylinositol 3'-kinase.
Topics: Animals; Cell Culture Techniques; CHO Cells; Chromones; Cricetinae; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Growth Hormone; Hepatocytes; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction; Telomerase; Time Factors | 2005 |
Elevated expression of NF-kappaB and Bcl-2 proteins in C2C12 myocytes during myogenesis is affected by PD98059, LY294002 and SB203580.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Chromones; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; Morpholines; Muscle Development; Myoblasts; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines | 2005 |
The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2.
Topics: Blotting, Western; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophil Granule Proteins; Eosinophils; Flavonoids; Humans; Indoles; Mitogen-Activated Protein Kinase 3; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Stereoisomerism; Superoxides | 2005 |
PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells.
Topics: Androstadienes; Animals; Becaplermin; Cells, Cultured; Chlorides; Chromones; Cyclosporine; Flavonoids; K Cl- Cotransporters; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Platelet-Derived Growth Factor; Potassium; Protein Phosphatase 1; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Symporters; Vanadates; Wortmannin | 2005 |
Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF).
Topics: Carrier Proteins; Cell Line, Tumor; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunohistochemistry; In Situ Hybridization; Membrane Proteins; Morpholines; Neoplasm Proteins; Neoplasms; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Transcription, Genetic; Up-Regulation; Vascular Endothelial Growth Factor A | 2005 |
[Exploration of ganglioside GM1 as an activation marker on T cells].
Topics: Antibodies, Monoclonal; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Biomarkers; CD3 Complex; Chromones; Flavonoids; G(M1) Ganglioside; Gene Expression Regulation; Lectins, C-Type; Lymphocyte Activation; Morpholines; Mycobacterium tuberculosis; T-Lymphocytes; Time Factors | 2005 |
Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis.
Topics: Animals; Apoptosis; Cell Size; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glomerular Mesangium; Hyperplasia; Hypertrophy; Kidney; Leptin; Leucine; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats | 2005 |
Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Chromones; Clozapine; Dibenzothiazepines; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluphenazine; Haloperidol; Humans; Morpholines; Nerve Growth Factor; Neurites; Olanzapine; PC12 Cells; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quetiapine Fumarate; Rats | 2005 |
Angiopoietin 1 is mitogenic for cultured endothelial cells.
Topics: Angiopoietin-1; Angiopoietin-2; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Mitogens; Morpholines; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction | 2005 |
Position of STAT-1 alpha in cycloheximide-dependent apoptosis triggered by TNF-alpha in human colorectal COLO 205 cancer cell line; role of polyphenolic compounds.
Topics: Apigenin; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Colorectal Neoplasms; Cycloheximide; Dose-Response Relationship, Drug; Flavonoids; Humans; Interferon-Stimulated Gene Factor 3; Kaempferols; Ligands; MAP Kinase Kinase Kinases; Morpholines; Phenols; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polyphenols; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Quercetin; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Time Factors; Tumor Escape; Tumor Necrosis Factor-alpha | 2005 |
Dissimilar effects of LY 294002 and PD 098059 in IGF-I-mediated inhibition of TGF-beta1 expression and apoptosis in bovine mammary epithelial cells.
Topics: Animals; Apoptosis; Cattle; Cell Line; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Insulin-Like Growth Factor I; Laser Scanning Cytometry; Mammary Glands, Animal; MAP Kinase Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; Transforming Growth Factor beta1 | 2005 |
HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.
Topics: Androstadienes; Butadienes; Cells, Cultured; Chromones; Flavonoids; HIV Envelope Protein gp120; Humans; Imidazoles; Macrophages; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptors, CCR5; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin | 2005 |
Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.
Topics: Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Caspase 8; Caspases; Cell Cycle; Cell Line, Tumor; Chromones; Colonic Neoplasms; Ecdysterone; Enzyme Activation; Fas Ligand Protein; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Membrane Glycoproteins; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Wortmannin | 2006 |
Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.
Topics: Apoptosis; Blotting, Western; Chromones; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Interleukin-10; Lipopolysaccharides; Morpholines; Neutrophils; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Pyridines | 2005 |
[Effect of EM201, an in vivo metabolite of erythromycin (EM), on signal transduction of IL-2 receptor].
Topics: Cells, Cultured; Chromones; Erythromycin; Flavonoids; Humans; Monocytes; Morpholines; Receptors, Interleukin-2; Signal Transduction; Sirolimus | 2004 |
Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer.
Topics: Adenoviridae; Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mutation; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Pyridines; Signal Transduction; Xenograft Model Antitumor Assays | 2005 |
Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils.
Topics: Chromones; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Inflammation; Kinetics; Leukocytes; Lipopolysaccharides; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Morpholines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peptidoglycan; Pyridines; Pyrimidines; src-Family Kinases; Staphylococcus aureus; Time Factors | 2005 |
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.
Topics: Animals; Carcinoma; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Humans; Isoenzymes; MAP Kinase Kinase Kinases; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radiation Tolerance; ras Proteins; RNA, Small Interfering; Transfection; Urinary Bladder Neoplasms | 2005 |
Effects of MEK1 and PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M arrest and cell death in Caco-2 cells.
Topics: Apoptosis; Caco-2 Cells; Cell Cycle; Cell Death; Chromones; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Isothiocyanates; MAP Kinase Kinase 1; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction | 2005 |
TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.
Topics: Cadherins; Catenins; Cell Adhesion; Cell Aggregation; Cell Line, Tumor; Cell Movement; Chromones; Down-Regulation; Flavonoids; Humans; Morpholines; Multiprotein Complexes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Proto-Oncogene Proteins p21(ras); PTEN Phosphohydrolase; Transforming Growth Factor beta | 2005 |
Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active phosphatidylinositol 3-kinase pathway and is inhibited via the mitogen-activated protein kinase signaling pathway.
Topics: Animals; Aromatase; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Estradiol; Flavonoids; Follicle Stimulating Hormone; Gene Expression Regulation, Enzymologic; Male; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Sertoli Cells; Signal Transduction | 2006 |
Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line.
Topics: Acrylates; Animals; Cadherins; Cell Line; Cell Proliferation; Chromones; Cytoskeletal Proteins; Down-Regulation; Flavonoids; Gene Expression Regulation, Enzymologic; Hepatocytes; Imidazoles; MAP Kinase Signaling System; Mice; Microvilli; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-raf; Pyridines; Signal Transduction; Snail Family Transcription Factors; Time Factors; Transcription Factors; Up-Regulation | 2006 |
ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells.
Topics: Animals; Calcium Signaling; Cell Line; Chelating Agents; Chromones; Egtazic Acid; Enzyme Inhibitors; Epidermis; Flavonoids; MAP Kinase Kinase Kinases; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Time Factors; Transfection; Vanadium; Vascular Endothelial Growth Factor A | 2005 |
Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression.
Topics: Animals; Calcium Signaling; Cell Line; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermis; Flavonoids; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nickel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Time Factors; Vascular Endothelial Growth Factor A | 2005 |
Differential regulation of interleukin-12 and tumour necrosis factor-alpha by phosphatidylinositol 3-kinase and ERK 1/2 pathways during Mycobacterium tuberculosis infection.
Topics: Analysis of Variance; Androstadienes; Antigens, Bacterial; Butadienes; Cells, Cultured; Chromones; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Interleukin-12; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mycobacterium tuberculosis; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Tuberculosis; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin.
Topics: Analysis of Variance; Biological Transport; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Chromones; Cytosol; Dose-Response Relationship, Drug; Estrenes; Female; Flavonoids; Humans; Immunoblotting; Indoles; Kallidin; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Protein Kinase C-epsilon; Pyrrolidinones; Stimulation, Chemical; Tetrahydroisoquinolines | 2006 |
p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis.
Topics: Adenocarcinoma; Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Chromones; Cisplatin; Female; Flavonoids; Flow Cytometry; Fluorescein-5-isothiocyanate; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Morpholines; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Protein Kinase Inhibitors; Rhodamines | 2006 |
Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways.
Topics: Aorta; Cell Movement; Cells, Cultured; Chromones; Dactinomycin; Dose-Response Relationship, Drug; Flavonoids; Homocysteine; Humans; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphoinositide-3 Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Time Factors | 2005 |
Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells.
Topics: Androstadienes; Angiopoietin-1; Angiopoietin-2; Animals; Cattle; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors; Flavonoids; Lung; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Transfection; Vascular Endothelial Growth Factor A; Wortmannin | 2006 |
Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells.
Topics: Blotting, Western; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chromones; Epithelium, Corneal; Flavonoids; Fluorescent Antibody Technique, Indirect; Humans; Insulin-Like Growth Factor I; Integrin beta1; Kalinin; MAP Kinase Signaling System; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Receptor, IGF Type 1; Up-Regulation | 2006 |
Contribution of Src-FAK signaling to the induction of connective tissue growth factor in renal fibroblasts.
Topics: Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Line, Transformed; Chromones; Colchicine; Collagen Type I; Connective Tissue Growth Factor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Extracellular Matrix; Fibroblasts; Flavonoids; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Humans; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Microscopy, Fluorescence; Models, Biological; Morpholines; Paclitaxel; Phalloidine; Rhodamines; Signal Transduction; src-Family Kinases; Transforming Growth Factor beta; Wortmannin | 2006 |
Not only insulin stimulates mitochondriogenesis in muscle cells, but mitochondria are also essential for insulin-mediated myogenesis.
Topics: Animals; Cell Line; Cell Survival; Chromones; Flavonoids; Insulin; Methacrylates; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Cells; Muscle Development; Muscle, Skeletal; Myogenin; Oligomycins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rotenone; Signal Transduction; Thiazoles; Uncoupling Agents | 2006 |
Oncolysis of pancreatic tumour cells by a gamma34.5-deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway.
Topics: Adenocarcinoma; Cell Line, Tumor; Chromones; Flavonoids; Gene Deletion; Genes, ras; Genetic Therapy; Herpes Simplex; Herpesvirus 1, Human; Humans; Immunoblotting; Mitogen-Activated Protein Kinase Kinases; Morpholines; Oncolytic Virotherapy; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Viral Proteins; Virus Replication | 2006 |
Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-10; Monocytes; Morpholines; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Receptors, Formyl Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Amyloid A Protein; Sulfones; Tumor Necrosis Factor-alpha | 2006 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells.
Topics: CD11b Antigen; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Flow Cytometry; HL-60 Cells; Humans; Morpholines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sensitivity and Specificity; Tretinoin | 2006 |
Insulin increases gelatinase activity in rat glomerular mesangial cells via ERK- and PI-3 kinase-dependent signalling.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Culture Media, Conditioned; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gelatinases; Insulin; Matrix Metalloproteinase 2; Mesangial Cells; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction | 2006 |
betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chromones; Enzyme Inhibitors; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Integrins; Molecular Sequence Data; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paxillin; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Receptors, Vitronectin; Signal Transduction; src-Family Kinases; Transforming Growth Factor beta | 2006 |
Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts.
Topics: Adolescent; Adult; Butadienes; Chromones; Fibroblasts; Flavonoids; Humans; Imidazoles; Interleukin-8; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Proteinase-Activated; Signal Transduction; Skin; STAT3 Transcription Factor; Thrombin; Tyrphostins | 2006 |
Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Breast Neoplasms; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Sequence Homology, Amino Acid; Transcription Factors; Transcription, Genetic | 2006 |
Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Endopeptidases; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, bcl-2; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Mice; Morpholines; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protozoan Proteins; Pyridines; Signal Transduction; Trypanosoma cruzi | 2006 |
Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways.
Topics: Adenocarcinoma; Cell Death; Cell Line, Tumor; Chromones; Disease Progression; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lung Neoplasms; Macrophage Colony-Stimulating Factor; MAP Kinase Kinase 1; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction | 2006 |
Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Angiopoietin-Like Protein 4; Angiopoietins; Animals; Blood Proteins; Chromones; Cycloheximide; Dactinomycin; Down-Regulation; Flavonoids; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Glucose; Insulin; Mice; Morpholines; Proto-Oncogene Proteins c-akt; RNA, Messenger; Tumor Necrosis Factor-alpha | 2006 |
Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin.
Topics: Androstadienes; Butadienes; Chromones; Flavonoids; HeLa Cells; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Interleukin-8; Morpholines; NF-kappa B; Nitriles; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Protein Kinase C; Repressor Proteins; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
The regulatory mechanism by which interleukin-6 stimulates GH-gene expression in rat GH3 cells.
Topics: Animals; Cell Line, Tumor; Chromones; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Growth Hormone; Imidazoles; Indoles; Interleukin-6; Maleimides; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor Pit-1; Transfection | 2006 |
The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cell Nucleus; Cell Survival; Chromones; Cyclooxygenase 2; Dinoprostone; Endocannabinoids; Endothelial Cells; Enzyme Activation; Flavonoids; Fluorescent Antibody Technique; Glycerides; Imidazoles; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Theilovirus | 2006 |
Insulin-like growth factor-I promotes resistance of bovine preimplantation embryos to heat shock through actions independent of its anti-apoptotic actions requiring PI3K signaling.
Topics: Animals; Apoptosis; Blastocyst; Cattle; Chromones; Enzyme Inhibitors; Female; Fertilization in Vitro; Flavonoids; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Hot Temperature; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Signal Transduction | 2007 |
Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Cytokine Receptor gp130; Flavonoids; Gene Expression Regulation; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress.
Topics: Adenine Nucleotides; Adenosine; Androstadienes; Animals; Cells, Cultured; Cerebral Cortex; Chromones; Flavonoids; Glucose; Insulin; Lactic Acid; Morpholines; Neurons; Oxidative Stress; Phosphocreatine; Pyruvic Acid; Rats; Rats, Wistar; Thioinosine; Wortmannin | 2006 |
Signaling pathway of insulin-like growth factor-II as a target of molecular therapy for hepatoblastoma.
Topics: Androstadienes; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Wortmannin | 2006 |
A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells.
Topics: Base Sequence; Cell Line, Transformed; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Chromones; Cobalt; Endothelial Cells; Endothelium, Vascular; Flavonoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Imidazoles; Interleukin-8; Molecular Sequence Data; Morpholines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; RNA, Messenger | 2006 |
ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells: involvement of PI3K and Erk signaling.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Chromones; ErbB Receptors; Flavonoids; Genes, ras; Genes, Reporter; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neuregulin-1; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyridines; Rats; Reactive Oxygen Species; Receptor, ErbB-4; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Transfection | 2006 |
Mitofusin 2 (Mfn2): a key player in insulin-dependent myogenesis in vitro.
Topics: Animals; Cell Survival; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Electron Transport Complex I; Electron Transport Complex IV; Enzyme Inhibitors; Flavonoids; GTP Phosphohydrolases; Hypoglycemic Agents; Insulin; Membrane Proteins; Mice; Mitochondria; Mitochondrial Proteins; Morpholines; Myoblasts; Phosphoinositide-3 Kinase Inhibitors; Rats | 2007 |
[The anti-tumoral effect of PI3K inhibitor and MEK inhibitor combined with STI571 on chronic myeloid leukemia cells in a bone marrow stromal cell co-culture system].
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Bone Marrow Cells; Cell Proliferation; Chromones; Coculture Techniques; Flavonoids; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperazines; Pyrimidines; Stromal Cells | 2006 |
Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells.
Topics: Androstadienes; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Chloride Channels; Chromones; CLC-2 Chloride Channels; Female; Flavonoids; Insulin-Like Growth Factor I; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Swine; Wortmannin | 2007 |
Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro.
Topics: Animals; Aromatase; Blotting, Northern; Cattle; Cells, Cultured; Chromones; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Follicle Stimulating Hormone; Follicular Phase; Granulosa Cells; Indoles; Insulin; Isoquinolines; Maleimides; MAP Kinase Signaling System; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; RNA, Messenger; Sulfonamides | 2006 |
Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Cyclin D1; Drug Resistance, Neoplasm; Estrogen Antagonists; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; S Phase; Signal Transduction; Tamoxifen; Time Factors | 2006 |
Interleukin-1beta up-regulates inducible nitric oxide by way of phosphoinositide 3-kinase-dependent in a cochlear cell model.
Topics: Animals; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; Imidazoles; Interleukin-1beta; Mice; Morpholines; Nitric Oxide Synthase Type II; Organ of Corti; Phosphatidylinositol 3-Kinases; Pyridines; Signal Transduction; Transcriptional Activation; Up-Regulation | 2006 |
PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway.
Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Cell Survival; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Down-Regulation; Flavonoids; G1 Phase; Humans; MAP Kinase Kinase Kinases; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; U937 Cells | 2007 |
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Aorta, Thoracic; Apigenin; Cattle; Cells, Cultured; Chromones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epoxy Compounds; Flavonoids; Inositol; Male; MAP Kinase Signaling System; Morpholines; Nitric Oxide Synthase Type III; Oxygenases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rats; Serine | 2007 |
Angiotensin II does not stimulate proliferation of rat thyroid PC Cl3 cell line.
Topics: Angiotensin II; Animals; Cell Line; Cell Proliferation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Indoles; Insulin; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Rats; RNA Interference; Signal Transduction; Thyroid Gland | 2006 |
Detection of vascular endothelial growth factor (VEGF) and VEGF receptors Flt-1 and KDR in canine mastocytoma cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Blotting, Northern; Cell Line, Tumor; Chromones; Dog Diseases; Dogs; Female; Flavonoids; Flow Cytometry; Immunohistochemistry; Male; Mastocytoma; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel (ENaC) currents in HT-29 colonic epithelial cells.
Topics: Amiloride; Biotinylation; Chromones; Colon; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Exocytosis; Flavonoids; HT29 Cells; Humans; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Structure, Tertiary; Syntaxin 1 | 2006 |
Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Dactinomycin; Enzyme Activation; Fibroblast Growth Factor 2; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A; Wortmannin | 2007 |
Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.
Topics: Animals; Base Sequence; Benzodiazepinones; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Flavonoids; Gastric Mucosa; Gastrins; GC Rich Sequence; Genes, Reporter; Humans; Luciferases; MAP Kinase Kinase 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Morpholines; Mucins; Muscle Proteins; Mutation; Peptides; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Receptor, Cholecystokinin B; RNA, Messenger; Signal Transduction; Staurosporine; Stomach; Time Factors; Transcription, Genetic; Transfection; Trefoil Factor-2 | 2007 |
Culture of human fibrosarcoma HT-1080 cells in presence of fibronectin activates MMP-2.
Topics: Actin Cytoskeleton; Actins; Cell Adhesion; Cell Line, Tumor; Chromones; Culture Media; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Fibrosarcoma; Flavonoids; Focal Adhesion Kinase 1; Humans; Integrin alpha5beta1; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Morpholines; Signal Transduction | 2006 |
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
Topics: Blotting, Western; Calcium; Cell Line, Tumor; Cell Movement; Chemotaxis; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Lysophospholipids; Morpholines; Neoplasm Invasiveness; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine | 2007 |
Requirement of multiple signaling pathways for the augmented production of hyaluronan by v-Src.
Topics: Animals; Cell Line; Chromones; Dimethyl Sulfoxide; Enzyme Inhibitors; Flavonoids; Gene Expression; Glucuronosyltransferase; Hyaluronan Synthases; Hyaluronic Acid; Immunoblotting; Isoenzymes; Janus Kinase 2; MAP Kinase Kinase 1; Morpholines; Mutation; Oncogene Protein pp60(v-src); Polyenes; Polyunsaturated Alkamides; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tyrphostins | 2005 |
Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells.
Topics: Androstadienes; Animals; Cell Movement; Cell Proliferation; Chemokine CXCL12; Chemokines, CXC; Chromones; Flavonoids; Insulin-Like Growth Factor I; Mesenchymal Stem Cells; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Inbred Lew; Receptors, CXCR4; Signal Transduction; Wortmannin | 2007 |
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation | 2007 |
Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling.
Topics: Animals; Cell Line; Cell Proliferation; Chromones; Colitis; Dextran Sulfate; Electroporation; Female; Flavonoids; Genetic Therapy; Hepatocyte Growth Factor; Imidazoles; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyridines; Regeneration; RNA, Small Interfering; Signal Transduction | 2007 |
Activation of intracellular signaling pathways is necessary for an increase in VDR expression and its nuclear translocation.
Topics: Active Transport, Cell Nucleus; Calcitriol; Cell Nucleus; Cells, Cultured; Chromones; Enzyme Inhibitors; Fatty Acids, Unsaturated; Flavonoids; Gene Expression Regulation; HL-60 Cells; Humans; Imidazoles; Leukemia; Models, Biological; Morpholines; Protein Biosynthesis; Pyridines; Receptors, Calcitriol; Signal Transduction | 2007 |
Involvement of the ERK/MAP kinase signalling pathway in milli-calpain activation and myogenic cell migration.
Topics: Animals; Calpain; Cell Line; Cell Movement; Chromones; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation; Immunoblotting; Insulin; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Myoblasts; MyoD Protein; Myogenin; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1 | 2007 |
Subunit S5a of the 26S proteasome is regulated by antiapoptotic signals.
Topics: Apoptosis; beta Catenin; Cell Line; Chromones; Flavonoids; HeLa Cells; Humans; I-kappa B Proteins; Lymphoid Enhancer-Binding Factor 1; Morpholines; Proteasome Endopeptidase Complex; Pyrazoles; Pyrimidines; RNA-Binding Proteins; RNA, Small Interfering; src-Family Kinases; Up-Regulation | 2007 |
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
Topics: Anticarcinogenic Agents; Carcinoma; Chromones; Female; Flavonoids; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neovascularization, Pathologic; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Phosphoinositide-3 Kinase Inhibitors; Repressor Proteins; Resveratrol; RNA, Small Interfering; Stilbenes; Transcriptional Activation; Transfection; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A | 2007 |
Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin | 2007 |
Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes.
Topics: Cell Line; Cell Separation; Cell Survival; Chromones; Flavonoids; Flow Cytometry; Gene Expression Regulation; Humans; Kinetics; Monocytes; Morpholines; NG-Nitroarginine Methyl Ester; Reactive Oxygen Species; Receptors, CCR2; Resveratrol; RNA, Messenger; Stilbenes | 2007 |
Participation of phosphatidyl inositol 3-kinase/protein kinase B and ERK1/2 pathways in interleukin-1beta stimulation of lactate production in Sertoli cells.
Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Interleukin-1beta; L-Lactate Dehydrogenase; Lactates; Male; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Sirolimus; Stimulation, Chemical; Transferrin; Wortmannin | 2007 |
Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonate 12-Lipoxygenase; Blotting, Northern; Blotting, Western; Cell Line; Cell Line, Transformed; Cell Proliferation; Cell Survival; Chromones; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Insulin-Like Growth Factor II; Keratinocytes; Mice; Mice, Hairless; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin | 2007 |
IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
Topics: Androstadienes; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biological Transport; Cell Line; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Immunohistochemistry; Indoles; Insulin-Like Growth Factor I; Isoquinolines; Male; Maleimides; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neurons; Oligonucleotides, Antisense; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Recombinant Proteins; Stroke; Sulfonamides; Wortmannin | 2007 |
Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12.
Topics: Animals; Butadienes; Cells, Cultured; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Imidazoles; Interleukin-12; Interleukin-4; Mast Cells; Mice; Morpholines; Nitriles; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Proteinase-Activated; RNA, Messenger; Trypsin; Tryptases; Tyrphostins | 2007 |
Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity.
Topics: Actins; Calcium; Calpain; Cell Polarity; Cells, Cultured; Chromones; Cytoskeleton; Dipeptides; Endothelial Cells; Flavonoids; Focal Adhesions; Gadolinium; Humans; Microscopy, Confocal; Morpholines; Neomycin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pseudopodia; RNA, Small Interfering; Stress, Mechanical; Talin; Vinculin | 2007 |
The inflammatory cytokine oncostatin M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways.
Topics: Aorta; Cell Proliferation; Cells, Cultured; Chromones; Coronary Vessels; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle, Smooth, Vascular; Oncostatin M; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins c-akt; Signal Transduction; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2007 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Humans; Lymphocytes; Macrophages; Male; Middle Aged; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Osteoarthritis; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Signal Transduction; Synovial Membrane; Vascular Endothelial Growth Factor A; Young Adult | 2007 |
The mitogen-activated protein kinase pathway tonically inhibits both basal and IGF-I-stimulated IGF-binding protein-5 production in mammary epithelial cells.
Topics: Animals; Apoptosis; Cattle; Cell Line; Chromones; Epithelial Cells; Female; Flavonoids; Gene Expression; Immunoblotting; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Mammary Glands, Animal; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glyburide; Hydrogen Sulfide; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Channel Blockers; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfides; Time Factors | 2008 |
Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells.
Topics: Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Kinase 1; Morpholines; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Vascular Endothelial Growth Factor A | 2007 |
PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.
Topics: Analgesics, Non-Narcotic; Animals; Axons; Axotomy; Blotting, Western; Butadienes; Chromones; Clodronic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Immunohistochemistry; Janus Kinases; Macrophages; Morpholines; Neuroprotective Agents; Nitriles; Optic Nerve Injuries; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; Retinal Ganglion Cells; Signal Transduction; STAT Transcription Factors; Tyrphostins | 2007 |
Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation.
Topics: Animals; Cell Line; Cell Proliferation; Chromones; Cyclic N-Oxides; Endothelial Cells; Enzyme Inhibitors; Fetus; Fibroblast Growth Factor 2; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitric Oxide; omega-N-Methylarginine; Phosphatidylinositol 3-Kinases; Phosphorylation; Placenta; Proto-Oncogene Proteins c-akt; Sheep; Signal Transduction; Vascular Endothelial Growth Factor A | 2008 |
ICAM-1 and p38 MAPK mediate fibrinogen-induced migration of human vascular smooth muscle cells.
Topics: Abciximab; Antibodies, Blocking; Antibodies, Monoclonal; Cell Movement; Chemotaxis; Chromones; DNA; Enzyme Inhibitors; Fibrinogen; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Immunoglobulin Fab Fragments; Intercellular Adhesion Molecule-1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Pyridines | 2007 |
Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation.
Topics: Anticarcinogenic Agents; Catechin; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Activation; Epithelial Cells; Flavonoids; Humans; Inhibitory Concentration 50; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors | 2008 |
Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line; Cells, Cultured; Chondrocytes; Chromones; Enzyme Induction; Enzyme Inhibitors; Enzymes; Flavonoids; Humans; Imidazoles; Interferon-gamma; Leptin; MAP Kinase Kinase 1; Morpholines; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Wortmannin | 2007 |
Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors.
Topics: Anthracenes; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Line, Tumor; Chromones; Drug Screening Assays, Antitumor; Drug Synergism; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Imidazoles; Leukemia; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; U937 Cells | 2008 |
Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation.
Topics: Cell Hypoxia; Chemokine CXCL12; Chemotaxis; Chromones; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, CXCR4 | 2007 |
Tumour necrosis factor-alpha-mediated human polymeric immunoglobulin receptor expression is regulated by both mitogen-activated protein kinase and phosphatidylinositol-3-kinase in HT-29 cell line.
Topics: Blotting, Northern; Chromones; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HT29 Cells; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, Polymeric Immunoglobulin; Secretory Component; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway.
Topics: Acne Vulgaris; Cell Line, Transformed; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Lipogenesis; MAP Kinase Signaling System; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sebaceous Glands; Sebum; Sterol Regulatory Element Binding Protein 1 | 2008 |
Downregulation of melanin synthesis by haginin A and its application to in vivo lightening model.
Topics: Agaricales; Animals; Cells, Cultured; Chromones; Down-Regulation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Guinea Pigs; Isoflavones; Lespedeza; MAP Kinase Signaling System; Melanins; Melanocytes; Mice; Mice, Inbred C57BL; Microphthalmia-Associated Transcription Factor; Models, Animal; Monophenol Monooxygenase; Morpholines; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Skin Pigmentation; Streptomyces; Ultraviolet Rays; Zebrafish | 2008 |
FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1.
Topics: Animals; Base Sequence; Blotting, Western; Carcinogens; Cell Line, Tumor; Chromones; Cloning, Molecular; DNA Primers; Ethylnitrosourea; Female; Fibroblast Growth Factor 1; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 9; Morpholines; NF-kappa B; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1 | 2008 |
Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium.
Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunohistochemistry; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; NF-kappa B; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors | 2008 |
BDNF increases the phagocytic activity in cultured iris pigment epithelial cells.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cell Culture Techniques; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Epithelial Cells; Flavonoids; Fluorescent Antibody Technique; Iris; Microscopy, Fluorescence; Morpholines; Phagocytosis; Phosphorylation; Pigment Epithelium of Eye; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Long-Evans; Rod Cell Outer Segment; Swine | 2008 |
Brain derived neurotrophic factor induces endothelial cells angiogenesis through AKT and ERK1/2 signal pathway.
Topics: Angiogenesis Inducing Agents; Brain-Derived Neurotrophic Factor; Chromones; Endothelial Cells; Flavonoids; Humans; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 3; Morpholines; Proto-Oncogene Proteins c-akt; Signal Transduction; Umbilical Veins | 2008 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chromones; Down-Regulation; Flavonoids; Humans; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multiprotein Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Invasiveness; Niacinamide; Nitriles; Phenylurea Compounds; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction; Sirolimus; Skin Neoplasms; Sorafenib; TOR Serine-Threonine Kinases; Transcription Factors; Wortmannin | 2008 |
Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways.
Topics: Animals; Arachidonic Acid; Ascorbic Acid; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Embryonic Stem Cells; Flavonoids; G1 Phase; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation | 2008 |
Granule formation in NGF-cultured mast cells is associated with expressions of pyruvate kinase type M2 and annexin I proteins.
Topics: Androstadienes; Animals; Annexin A1; Carbazoles; Cell Line, Tumor; Chromones; Cytoplasmic Granules; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Female; Flavonoids; Humans; Immunoblotting; Indole Alkaloids; Mast Cells; Mice; Mice, Inbred BALB C; Microscopy, Electron; Morpholines; Nerve Growth Factor; Phosphorylation; Pyruvate Kinase; RNA, Small Interfering; Transfection; Tumor Necrosis Factor-alpha; Wortmannin | 2008 |
Estrogen and the Ca2+-mobilizing agonist ATP evoke acute NO synthesis via distinct pathways in an individual human vascular endothelium-derived cell.
Topics: Adenosine Triphosphate; Apamin; Calcium Signaling; Cell Line; Charybdotoxin; Chelating Agents; Chromones; Cytophotometry; Egtazic Acid; Endothelial Cells; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Flavonoids; Fulvestrant; Humans; Membrane Potentials; Mitogen-Activated Protein Kinases; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Protein Kinase Inhibitors; Time Factors; Up-Regulation | 2008 |
Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3'K and ERK1/2 MAPK signal transduction pathways.
Topics: Animals; Chemokine CCL11; Chromones; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NIH 3T3 Cells; Oncostatin M; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-jun; RNA Interference; Signal Transduction; Transcription Factor AP-1 | 2008 |
Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy.
Topics: Animals; Anthracenes; Chromones; Female; Flavonoids; Interleukin-10; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Morpholines; Placenta; Pregnancy; Pregnancy, Animal; Spleen; Thy-1 Antigens; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2009 |
Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.
Topics: Androstadienes; Cells, Cultured; Chemotaxis; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Isoxazoles; Killer Cells, Natural; Lysophospholipids; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Propionates; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid; Wortmannin | 2008 |
Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.
Topics: Benzazepines; beta Catenin; Cell Movement; Chromones; Epidermal Growth Factor; Female; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pregnancy; Pregnancy Trimester, First; Proto-Oncogene Proteins c-akt; Trophoblasts | 2008 |
A role for IL-18 in human neutrophil apoptosis.
Topics: Apoptosis; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-18; Kinetics; Lipopolysaccharides; Morpholines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Propidium; Pyridines; Receptors, Interleukin-18; Signal Transduction | 2008 |
Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells.
Topics: Androstadienes; Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Chromones; Flavonoids; Ghrelin; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Wortmannin | 2008 |
Vincristine attenuates doxorubicin cardiotoxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Chromones; Cytochromes c; Cytoprotection; Doxorubicin; Flavonoids; Humans; Male; Mice; Mice, Inbred C57BL; Morpholines; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Vincristine | 2008 |
TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.
Topics: Anthracenes; Antigens, CD; B7-H1 Antigen; Carcinoma, Transitional Cell; Cell Line, Tumor; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharide Receptors; Lipopolysaccharides; MAP Kinase Signaling System; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyridines; Toll-Like Receptor 4; Up-Regulation; Urinary Bladder Neoplasms | 2008 |
In vitro effects on MCF-7 breast cancer cells of signal transduction inhibitor/tamoxifen/eicosapentaenoic acid combinations and their simultaneous delivery across skin.
Topics: Administration, Cutaneous; Animals; Breast Neoplasms; Cell Line, Tumor; Chromones; Cyclooxygenase 2; Dimethyl Sulfoxide; Eicosapentaenoic Acid; Female; Fish Oils; Flavonoids; Humans; MAP Kinase Signaling System; Morpholines; Permeability; Pharmaceutical Vehicles; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin; Swine; Tamoxifen | 2008 |
The effect of serotonin on GABA synthesis in cultured rat spinal dorsal horn neurons.
Topics: Actins; Animals; Blotting, Western; Butadienes; Cell Death; Cell Differentiation; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; Mitogen-Activated Protein Kinase 1; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Posterior Horn Cells; Rats; Serotonin | 2008 |
The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.
Topics: Animals; Apoptosis; Cells, Cultured; Chromones; Corticosterone; Enzyme Inhibitors; Female; Flavonoids; Hippocampus; Insulin; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pregnancy; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction | 2008 |
Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Chromones; Ciliary Neurotrophic Factor; Dose-Response Relationship, Drug; Female; Flavonoids; Ganglia, Spinal; Immunohistochemistry; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Neuroprotective Agents; Phosphorylation; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Tyrphostins | 2008 |
Ras-mediated up-regulation of survivin expression in cytokine-dependent murine pro-B lymphocytic cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Carrier Proteins; Cell Cycle; Cell Line; Chromones; Enhancer Elements, Genetic; Flavonoids; Gene Expression Regulation; Genes, ras; Humans; Inhibitor of Apoptosis Proteins; Interleukin-3; MAP Kinase Signaling System; Mice; Microtubule-Associated Proteins; Morpholines; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Repressor Proteins; Signal Transduction; Sirolimus; Survivin; TOR Serine-Threonine Kinases; Transfection | 2008 |
Leptin protects hippocampal CA1 neurons against ischemic injury.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; In Situ Nick-End Labeling; Leptin; Male; Morpholines; Neurons; Neuroprotective Agents; Oncogene Protein v-akt; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Hemangiopoietin promotes endothelial cell proliferation through PI-3K/Akt pathway.
Topics: Bromodeoxyuridine; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Endothelial Cells; Enzyme Activation; Fibroblast Growth Factor 2; Flavonoids; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteoglycans; Proto-Oncogene Proteins c-akt; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A | 2008 |
Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling.
Topics: Anthracenes; Base Sequence; Cell Line, Tumor; Chromones; Cytochrome P450 Family 7; Elafin; Enzyme Activation; Estradiol; Estrogens; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Molecular Sequence Data; Morpholines; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Pyridines; Steroid Hydroxylases | 2008 |
Effect of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Chromones; Collagen; Electromagnetic Fields; Equipment Design; Flavonoids; Imidazoles; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction | 2008 |
Src activity alters alpha3 integrin expression in colon tumor cells.
Topics: Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Colonic Neoplasms; Down-Regulation; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Integrin alpha3; Matrix Metalloproteinase 7; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidines; src-Family Kinases | 2009 |
Hypothalamic preproghrelin gene expression is repressed by insulin via both PI3-K/Akt and ERK1/2 MAPK pathways in immortalized, hypothalamic neurons.
Topics: Animals; Cell Line; Chromones; Down-Regulation; Flavonoids; Ghrelin; Hypothalamus; Insulin; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin | 2009 |
Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway.
Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell Movement; Chromones; Flavonoids; Focal Adhesion Kinase 1; Humans; Integrin alphaVbeta3; Lung Neoplasms; Morpholines; NF-kappa B; Oncogene Protein v-akt; Osteopontin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proline; Signal Transduction; Thiocarbamates; Tosylphenylalanyl Chloromethyl Ketone | 2009 |
[Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells].
Topics: 8,11,14-Eicosatrienoic Acid; Apigenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2008 |
Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes, White; Adiponectin; Amino Acids; Animals; Carrier Proteins; Cell Differentiation; Chromones; Flavonoids; Hydrogen-Ion Concentration; Insulin; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2008 |
Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells.
Topics: Animals; Apoptosis; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoxia; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Stem Cells | 2008 |
HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling.
Topics: AIDS Dementia Complex; Blood-Brain Barrier; Brain; Cell Adhesion; Cell Movement; Cells, Cultured; Chromones; Cytokines; Endothelial Cells; Enzyme Inhibitors; Flavonoids; HIV Envelope Protein gp120; HIV-1; Humans; Interleukin-6; Interleukin-8; Microvessels; Mitogen-Activated Protein Kinase Kinases; Models, Neurological; Monocytes; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; STAT1 Transcription Factor; Vidarabine | 2009 |
Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent.
Topics: Acute Lung Injury; Animals; Antigen-Antibody Complex; Apoptosis; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Chromones; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Lipopolysaccharides; Male; Morpholines; Neutrophils; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, IgG; Tumor Necrosis Factor-alpha | 2009 |
Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Movement; Chalcones; Chromones; Flavonoids; Gene Expression Regulation, Developmental; Melanocytes; Mitogen-Activated Protein Kinases; Morpholines; Mutation; Papaverine; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-kit; Zebrafish | 2008 |
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.
Topics: Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Chromones; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Excitatory Amino Acid Transporter 2; Flavonoids; Glial Fibrillary Acidic Protein; Immunosuppressive Agents; Male; Monomeric GTP-Binding Proteins; Morpholines; Neuropeptides; Protein Kinases; Ras Homolog Enriched in Brain Protein; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sirolimus; Spinal Cord Injuries; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Up-Regulation; Vimentin | 2009 |
Intracellular signaling pathways involved in inhibition of PAI-1 expression by CNP in endothelial cells.
Topics: Blotting, Western; Cell Line; Cell Line, Tumor; Chromones; Cyclic GMP; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Natriuretic Agents; Natriuretic Peptide, C-Type; NF-kappa B; Phosphorylation; Plasminogen Activator Inhibitor 1; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.
Topics: Adult; Antigens, CD; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Resistance, Neoplasm; Estradiol; Female; Flavonoids; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Predictive Value of Tests; Proportional Hazards Models; Protein Kinase Inhibitors; Receptors, Estrogen; Receptors, Transferrin; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Risk Assessment; RNA, Messenger; Tamoxifen; Time Factors; Tissue Array Analysis; Transferrin; Treatment Outcome | 2010 |
Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells.
Topics: Anthracenes; Cell Line; Chromones; Colforsin; Corticotropin-Releasing Hormone; Dexamethasone; Flavonoids; Genes, Reporter; Humans; Hypothalamus; Imidazoles; Isoquinolines; Morpholines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Regulatory Elements, Transcriptional; Sequence Deletion; Sulfonamides; Transfection | 2008 |
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Chromones; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Endothelin-1; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hypoglycemic Agents; Immunoprecipitation; Male; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Myocytes, Cardiac; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polymerase Chain Reaction; Protein Binding; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium-Hydrogen Exchangers; Voltage-Dependent Anion Channels | 2009 |
Coordinated integrin and growth factor regulation of primary keratinocyte migration mediated through extracellular signal regulated kinase and phosphoinositide 3-kinase.
Topics: Animals; Antibodies, Blocking; Cell Culture Techniques; Cell Migration Inhibition; Cell-Matrix Junctions; Chemotaxis; Chromones; Collagen Type I; Epidermal Growth Factor; Fibronectins; Flavonoids; Hepatocyte Growth Factor; Integrin alpha2beta1; Integrin alpha5beta1; Keratinocytes; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Morpholines; Phosphatidylinositol 3-Kinases; Signal Transduction | 2009 |
PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bufanolides; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Flavonoids; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-cbl; Signal Transduction; Stomach Neoplasms; Time Factors | 2009 |
CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK.
Topics: Animals; B-Lymphocytes; Benzylamines; Bone Marrow; Cell Line, Tumor; Chemokine CXCL12; Chemotaxis, Leukocyte; Chromones; Cyclams; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heterocyclic Compounds; Humans; Imidazoles; Mice; Mice, Inbred NOD; Mice, SCID; Morpholines; Neoplastic Stem Cells; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Receptors, CXCR4 | 2009 |
Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia.
Topics: Adjuvants, Immunologic; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; Carrier Proteins; Cell Line; Cell Proliferation; Chromones; Enzyme Inhibitors; Flavonoids; Lectins, C-Type; Lymphocyte Activation; Macrophages; MAP Kinase Kinase Kinases; Mice; Morpholines; Naphthoquinones; NF-kappa B; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Polysaccharides; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Splenomegaly; Tinospora; Toll-Like Receptor 4; TOR Serine-Threonine Kinases | 2009 |
Interplay between MEK and PI3 kinase signaling regulates the subcellular localization of protein kinases ERK1/2 and Akt upon oxidative stress.
Topics: Chromones; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O3; Forkhead Transcription Factors; HeLa Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Morpholines; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Subcellular Fractions | 2009 |
Glucose regulated protein 78 prompts scavenger receptor A-mediated secretion of tumor necrosis factor-α by RAW 264.7 cells.
Topics: 6-Aminonicotinamide; Animals; Cell Line; Chromones; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Flavonoids; Heat-Shock Proteins; Lipoproteins, LDL; Macrophages; MAP Kinase Kinase Kinases; Mice; Morpholines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Scavenger Receptors, Class A; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.
Topics: Butadienes; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Chromones; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases | 2009 |
Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutant.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Cell Survival; Chromones; Dopamine; Enzyme Inhibitors; Flavonoids; Humans; Immunoprecipitation; Mesencephalon; Morpholines; Neurons; Nitriles; Nuclear Receptor Subfamily 4, Group A, Member 2; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Stability; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Common carp (Cyprinus carpio) insulin-like growth factor binding protein-2 (IGFBP-2): molecular cloning, expression profiles, and hormonal regulation in hepatocytes.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Carps; Cells, Cultured; Chromones; Cloning, Molecular; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation; Hepatocytes; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin-Like Growth Factor Binding Protein 2; Kidney; Liver; Male; Morpholines; Myocardium; Ovary; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Retina; RNA, Messenger; Testis | 2009 |
Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chick Embryo; Chickens; Chromones; Epithelium; Flavonoids; Humans; Immunoblotting; Mesoderm; Microscopy, Fluorescence; Morpholines; Oxygen; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Receptors, Urokinase Plasminogen Activator; RNA, Small Interfering; Signal Transduction; Tubulin; Urokinase-Type Plasminogen Activator; Vimentin | 2009 |
Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.
Topics: Antineoplastic Agents, Hormonal; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tamoxifen | 2010 |
Differential inhibition of single and cluster type tumor cell migration.
Topics: Adolescent; Bone Neoplasms; Cell Culture Techniques; Cell Movement; Cell Proliferation; Chromones; Deoxyuridine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Flavonoids; Humans; Imidazoles; Male; Morpholines; Okadaic Acid; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Tumor Cells, Cultured | 2009 |
Basic fibroblast growth factor increases intracellular magnesium concentration through the specific signaling pathways.
Topics: Androstadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Endothelial Cells; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Humans; Imidazoles; Intracellular Space; Magnesium; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrrolidinones; Signal Transduction; Tyrphostins; Wortmannin | 2009 |
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Hypoxia; Cells, Cultured; Chromones; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-1beta; Interleukin-6; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Synovial Membrane; Vascular Endothelial Growth Factor A | 2009 |
Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFbeta3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB si
Topics: Analysis of Variance; Animals; Astrocytes; Blotting, Western; Cells, Cultured; Chromones; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolysin; Fibrinolytic Agents; Fibroblast Growth Factors; Flavonoids; Immunohistochemistry; Microglia; Morpholines; Nerve Growth Factors; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta3 | 2009 |
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Chromones; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Heparin-binding EGF-like Growth Factor; Humans; Integrins; Intercellular Signaling Peptides and Proteins; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Signal Transduction | 2009 |
Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways.
Topics: Arteries; Butadienes; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Culture Media, Serum-Free; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Morpholines; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Placenta; Pregnancy; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Vascular Endothelial Growth Factor A | 2009 |
Targeting HER2 signaling pathway for radiosensitization: alternative strategy for therapeutic resistance.
Topics: Antineoplastic Agents; Breast Neoplasms; Butadienes; Cell Cycle; Cell Line, Tumor; Chromones; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Morpholines; Nitriles; Radiation-Sensitizing Agents; Receptor, ErbB-2; RNA Interference; Signal Transduction | 2009 |
Mitogenic regulation of p27(Kip1) gene is mediated by AP-1 transcription factors.
Topics: Blotting, Western; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromones; Computational Biology; Cyclin-Dependent Kinase Inhibitor p27; Electrophoretic Mobility Shift Assay; Flavonoids; Flow Cytometry; Humans; MAP Kinase Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Multimerization; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
A synthetic analog of 15-epi-lipoxin A4 inhibits human monocyte apoptosis: involvement of ERK-2 and PI3-kinase.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Humans; Inflammation; Lipoxins; Mitochondria; Mitogen-Activated Protein Kinase 1; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled | 2010 |
In vitro delivery of anti-breast cancer agents directly via the mammary papilla (nipple).
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chromatography, High Pressure Liquid; Chromones; Diffusion; Drug Delivery Systems; Excipients; Female; Flavonoids; Mammary Glands, Animal; Morpholines; Nipples; Permeability; Solvents; Swine; Tamoxifen | 2010 |
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Topics: Carcinoma; Caveolin 1; Cell Line, Tumor; Chromones; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neoplasm Invasiveness; Pancreatic Ducts; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Messenger; RNA, Small Interfering | 2010 |
EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor.
Topics: Amiloride; Amphiregulin; Animals; Benzothiazoles; Blotting, Western; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; EGF Family of Proteins; Epidermal Growth Factor; Epithelial Sodium Channels; Flavonoids; Glycoproteins; Heparin-binding EGF-like Growth Factor; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Ion Transport; Kidney Tubules, Collecting; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Sodium; Sodium Channel Blockers; Transforming Growth Factor alpha; Tyrphostins | 2010 |
Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Blotting, Western; Cell Survival; Chromones; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin-Like Growth Factor I; Lithium Chloride; Morpholines; Neurotoxins; Parkinson Disease; PC12 Cells; Protein Kinase Inhibitors; Rats; Recombinant Proteins | 2010 |
Lewis(y) antigen stimulates the growth of ovarian cancer cells via regulation of the epidermal growth factor receptor pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fucosyltransferases; Gefitinib; Humans; Lewis Blood Group Antigens; Morpholines; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines | 2010 |
Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia-reperfusion.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Guinea Pigs; Hemodynamics; Immunohistochemistry; Male; Methyl Ethers; Morpholines; Myocardium; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Sevoflurane | 2010 |
IL-29 and IFN-α regulate the expression of MxA, 2',5'-OAS and PKR genes in association with the activation of Raf-MEK-ERK and PI3K-AKT signal pathways in HepG2.2.15 cells.
Topics: 2',5'-Oligoadenylate Synthetase; Chromones; eIF-2 Kinase; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; GTP-Binding Proteins; Hep G2 Cells; Humans; Interferon-alpha; Interferons; Interleukins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Myxovirus Resistance Proteins; Phosphorylation; raf Kinases; RNA, Messenger; Signal Transduction; Up-Regulation | 2011 |
VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chromones; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mice; Morpholines; Neuroendocrine Tumors; Octreotide; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Sirolimus; Somatostatin; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2010 |
Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia.
Topics: Animals; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypoxia; Male; Morpholines; Oxygen; Perfusion; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2010 |
Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Animals; Antineoplastic Agents, Phytogenic; Chromones; Drug Interactions; Enzyme Activation; Flavonoids; Free Radical Scavengers; Mice; Mitogen-Activated Protein Kinase 1; Morpholines; Naphthoquinones; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Pyrimidines; src-Family Kinases; Superoxides | 2010 |
Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways.
Topics: Antithrombins; Cells, Cultured; Chromones; Endothelium, Vascular; Factor Xa; Flavonoids; Hirudins; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Sulfones; Thrombin; Thromboplastin; Up-Regulation | 2011 |
Proinflammatory effects of muramyldipeptide on human gingival fibroblasts.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adult; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemokine CCL2; Chemokine CXCL10; Chemokine CXCL11; Chromones; Chronic Periodontitis; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Gingiva; Humans; Imidazoles; Inflammation Mediators; Interferon-gamma; Interleukin-6; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Morpholines; Nod2 Signaling Adaptor Protein; Periodontal Attachment Loss; Periodontal Pocket; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Tumor Necrosis Factor-alpha | 2010 |
Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells.
Topics: alpha-MSH; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Chromones; Curcumin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Melanins; Melanoma; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Morpholines; Oxidoreductases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction | 2010 |
Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells.
Topics: Alkaline Phosphatase; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chromones; Core Binding Factor Alpha 1 Subunit; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Signal Transduction; Sp7 Transcription Factor; Transcription Factors; Up-Regulation | 2010 |
Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells.
Topics: Animals; Bone Morphogenetic Protein 4; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle Cells; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells | 2010 |
Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK.
Topics: Blotting, Western; Cell Differentiation; Cell Line; Cell- and Tissue-Based Therapy; Chromones; Diabetes Mellitus, Type 1; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Humans; Immunohistochemistry; Insulin-Secreting Cells; Laminin; Lentivirus; Mesenchymal Stem Cells; Morpholines; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2010 |
ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Morpholines; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.
Topics: Cell Proliferation; Cells, Cultured; Chromones; Fibroblast Growth Factor 2; Flavonoids; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Interferon-gamma; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Quinoxalines; Thiazolidinediones; Trans-Activators | 2010 |
Adropin is a novel regulator of endothelial function.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Gene Silencing; Humans; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; RNA, Messenger; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Insulin stimulates gene expression of ferritin light chain in osteoblast cells.
Topics: Animals; Apoferritins; Blotting, Western; Cell Line; Chromones; Dichlororibofuranosylbenzimidazole; Flavonoids; Gene Expression Regulation; Insulin; Iron; Morpholines; Osteoblasts; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Enhanced sensitivity to rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Cell Line, Tumor; Cell Proliferation; Chromones; Culture Media; Dose-Response Relationship, Drug; Estrogens; Flavonoids; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2011 |
Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (-)-Epigallocatechin gallate via ERK MAP kinase pathway.
Topics: Catechin; Cells, Cultured; Chromones; Connexin 43; Culture Media, Serum-Free; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gap Junctions; Humans; Imidazoles; Morpholines; NG-Nitroarginine Methyl Ester; Pyridines; RNA, Small Interfering; Signal Transduction | 2011 |
Protective effects of IGF-1 on neurons under condition of hypoxia and the role of PI3K signal pathway.
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Chromones; Flavonoids; Insulin-Like Growth Factor I; Morpholines; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2011 |
Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells.
Topics: Amino Acid Sequence; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Chromones; Cloning, Molecular; Cyclin B1; Cyclin D1; Down-Regulation; Epidermal Growth Factor; Flavonoids; Gene Knockdown Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Molecular Sequence Data; Morpholines; Neoplasm Proteins; Nerve Tissue Proteins; Phosphorylation; Prostate; Proto-Oncogene Proteins c-akt; Signal Transduction; Tetraploidy; Up-Regulation | 2011 |
p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.
Topics: Alkaline Phosphatase; Animals; Cell Differentiation; Chromones; Class Ia Phosphatidylinositol 3-Kinase; Cyclin D; Cyclin E; Enzyme Inhibitors; Flavonoids; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Morpholines; Osteoblasts; Proto-Oncogene Proteins c-akt | 2011 |
Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801.
Topics: 4-Butyrolactone; Animals; Cell Line; Chromones; Erythropoietin; Flavonoids; Gene Expression Regulation; Glucose; Imidazoles; L-Lactate Dehydrogenase; Male; Morpholines; Neurons; Oxygen; Plasmids; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Repressor Proteins; Transcription Factors | 2011 |
Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation; Chromones; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Mitogen-Activated Protein Kinases; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Tumor Cells, Cultured | 2011 |
Visfatin inhibits apoptosis of pancreatic β-cell line, MIN6, via the mitogen-activated protein kinase/phosphoinositide 3-kinase pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cell Proliferation; Chromones; Cytochromes c; Drug Synergism; Enzyme Activation; Flavonoids; Insulin-Secreting Cells; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Morpholines; Nicotinamide Phosphoribosyltransferase; Obesity; Palmitic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2 | 2011 |
Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.
Topics: 14-alpha Demethylase Inhibitors; 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Eicosanoids; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, Reporter; Humans; Isoquinolines; Ketoconazole; Luciferases; Mitogen-Activated Protein Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinidine; RNA; Sulfonamides; Transfection | 2011 |
Astaxanthin improves stem cell potency via an increase in the proliferation of neural progenitor cells.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neural Stem Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Xanthophylls | 2010 |
Phosphorylation of GSK-3β mediates intralipid-induced cardioprotection against ischemia/reperfusion injury.
Topics: Animals; Calcium; Chromones; Emulsions; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Ischemic Postconditioning; Male; Mice; Mice, Inbred C57BL; Morpholines; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Phosphorylation; Rats; Rats, Sprague-Dawley; Soybean Oil | 2011 |
Interleukin-6 up-regulates the expression of interleukin-15 is associated with MAPKs and PI3-K signaling pathways in the human keratinocyte cell line, HaCaT.
Topics: Cell Line; Chromones; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-15; Interleukin-6; Keratinocytes; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger; Up-Regulation | 2012 |
[Effects of PD98059 and LY294002 on subcutaneous xenograft of human endometrial carcinoma in nude mice].
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Synergism; Endometrial Neoplasms; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2011 |
Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.
Topics: Butadienes; Caco-2 Cells; Chromones; Enzyme Inhibitors; ErbB Receptors; Estrenes; Flavonoids; Focal Adhesion Kinase 2; Humans; Intestines; Lysophospholipids; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C beta; Pyrrolidinones; Receptors, Lysophosphatidic Acid; rho-Associated Kinases; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers | 2011 |
Stretch-inducible expression of connective tissue growth factor (CTGF) in human osteoblasts-like cells is mediated by PI3K-JNK pathway.
Topics: Anthracenes; Cell Line; Chromones; Connective Tissue Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; JNK Mitogen-Activated Protein Kinases; Morpholines; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Stress, Mechanical | 2011 |
Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides.
Topics: Aggrecans; Animals; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Chromones; Collagen Type II; Drug Therapy, Combination; Endopeptidases; Flavonoids; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Hyaluronan Receptors; Hyaluronic Acid; Imidazoles; Lactones; Morpholines; Oligosaccharides; Pyridines; Sesquiterpenes, Eudesmane; Signal Transduction; Viscosupplements | 2012 |
Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated.
Topics: Amides; Cell Movement; Cells, Cultured; Chemotaxis; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organophosphonates; Protein Folding; Pyridines; Pyrimidines; Signal Transduction; Thrombospondin 1 | 2011 |
Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of β-catenin and STAT1 in chronic myeloid leukemia cells.
Topics: Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Benzamides; beta Catenin; Cell Line, Tumor; Chromones; COP9 Signalosome Complex; Down-Regulation; Enzyme Inhibitors; Flavonoids; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Morpholines; Oncogene Protein v-akt; Peptide Hydrolases; Piperazines; Promoter Regions, Genetic; Pyrimidines; STAT1 Transcription Factor; Transcription Factor 4; Transcription Factors | 2011 |
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Ethanol; Flavonoids; Flowers; Genetic Vectors; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Morpholines; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Protein Transport; Prunella; Pyridines; Sepsis; Signal Transduction; Transfection | 2012 |
Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line, Tumor; Chromones; Cyclic AMP Response Element-Binding Protein; Deoxyadenosines; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Melanins; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2012 |
Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism.
Topics: Animals; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Hepatocytes; I-kappa B Proteins; Imidazoles; Insulin; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Morpholines; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Plasmids; Proto-Oncogene Proteins c-akt; Pyridines; Rats | 2012 |
Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells.
Topics: Angiogenesis Inducing Agents; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Endothelial Cells; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ghrelin; Heart Ventricles; Male; MAP Kinase Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Signal Transduction | 2012 |
The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study.
Topics: Adiponectin; Cell Line; Cell Movement; Cell Proliferation; Chromones; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Leptin; Microcirculation; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors | 2012 |
Lewis y regulate cell cycle related factors in ovarian carcinoma cell RMG-I in vitro via ERK and Akt signaling pathways.
Topics: Antibodies; Cell Line, Tumor; Chromones; Cyclin A; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fucosyltransferases; Humans; Lewis Blood Group Antigens; Morpholines; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction | 2012 |
Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; HEK293 Cells; Humans; Iodine Radioisotopes; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; RNA, Messenger; Sirolimus; Symporters; Thyroid Gland; Thyrotropin; TOR Serine-Threonine Kinases | 2012 |
Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.
Topics: Bone Morphogenetic Protein 4; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell Proliferation; Chromones; Colonic Neoplasms; Down-Regulation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Morpholines; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Transcription, Genetic | 2012 |
EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Chromones; Cystadenocarcinoma, Serous; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; Female; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Morpholines; Neoplasm Invasiveness; Ovarian Neoplasms | 2012 |
Cockroach allergen Per a 7 down-regulates expression of Toll-like receptor 9 and IL-12 release from P815 cells through PI3K and MAPK signaling pathways.
Topics: Allergens; Animals; Blotting, Western; Butadienes; Cell Line, Tumor; Chromones; Cockroaches; Down-Regulation; Flavonoids; Flow Cytometry; Gene Expression Regulation; Imidazoles; Insect Proteins; Interleukin-12; MAP Kinase Signaling System; Mast Cells; Mice; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Recombinant Proteins; RNA, Messenger; Time Factors; Toll-Like Receptor 9 | 2012 |
NGF promotes cell cycle progression by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation in human corneal epithelial cells.
Topics: Cell Cycle; Cell Proliferation; Chromones; Cornea; Cyclin D; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nerve Growth Factor; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors | 2012 |
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways.
Topics: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Chromones; Enzyme Inhibitors; Fibroblasts; Flavonoids; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury | 2012 |
[Effect of ischemic postconditioning on phosphatidylinositol-3-OH kinase and extracellular signal-regulated protein kinase in rats with hepatic ischemia-reperfusion injury].
Topics: Animals; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemic Postconditioning; Liver; Male; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Chromones; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Female; Flavonoids; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Morpholines; Ovarian Neoplasms; Phosphoinositide-3 Kinase Inhibitors; S Phase; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2012 |
L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation.
Topics: Apoptosis; Calcium; Cell Line; Cell Survival; Chromones; Endothelial Cells; Endothelium, Vascular; Flavonoids; Glutamates; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Ornithine; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction; Tea; Vasodilation | 2013 |
The release of glutamate from cortical neurons regulated by BDNF via the TrkB/Src/PLC-γ1 pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cerebral Cortex; Chromones; Embryo, Mammalian; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Glutamic Acid; Indole Alkaloids; Morpholines; Neurons; Phospholipase C gamma; Phosphorylation; Primary Cell Culture; Pyrimidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; src-Family Kinases | 2013 |
Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.
Topics: Adipose Tissue; Animals; Body Composition; Cell Line; Chromones; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein; Feedback, Physiological; Flavonoids; Gene Knock-In Techniques; Genotype; Growth Hormone; Growth Hormone-Releasing Hormone; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Rats; RNA, Messenger; Signal Transduction; Somatotrophs; Transcription Factor Pit-1; Weight Gain | 2012 |
Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Benzamides; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Flavonoids; Insulin-Like Growth Factor I; Isotope Labeling; Mice; Morpholines; Nucleosome Assembly Protein 1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Proteome; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Signal Transduction | 2012 |
Regulation of protease-activated receptor-1 expression in human buccal fibroblasts stimulated with arecoline.
Topics: Acetylcysteine; Arecoline; Blotting, Western; Cell Culture Techniques; Cholinergic Agonists; Chromones; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Immunohistochemistry; Morpholines; Mouth Mucosa; Nitrobenzenes; Oral Submucous Fibrosis; Receptor, PAR-1; Rifabutin; Sulfonamides | 2013 |
Alterations in tyrosine kinase receptor (Trk) expression induced by insulin-like growth factor-1 in cultured dorsal root ganglion neurons.
Topics: Analysis of Variance; Animals; Cells, Cultured; Chromones; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Flavonoids; Ganglia, Spinal; Gene Expression Regulation; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Microtubule-Associated Proteins; Morpholines; Neurons; Oncogene Protein v-akt; Rats; Receptor Protein-Tyrosine Kinases; RNA, Messenger | 2013 |
Insulin upregulates the expression of zinc finger and BTB domain-containing 7A in HepG2 cells.
Topics: Binding Sites; Chromones; DNA-Binding Proteins; Flavonoids; Hep G2 Cells; Humans; Insulin; Mitogen-Activated Protein Kinases; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins c-akt; RNA, Messenger; Sp1 Transcription Factor; Transcription Factors; Up-Regulation | 2012 |
Upregulation of macrophage-specific functions by oxidized LDL: lysosomal degradation-dependent and -independent pathways.
Topics: Acetylcysteine; Cell Differentiation; Cells, Cultured; Chloroquine; Chromones; Copper Sulfate; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression; Humans; Imidazoles; Leukocytes, Mononuclear; Lipoproteins, LDL; Lysosomes; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; Naphthalenes; NF-kappa B; Oxidation-Reduction; PPAR gamma; Proteolysis; Pyridines; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation; Up-Regulation | 2013 |
Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts.
Topics: Acetophenones; Benzopyrans; Cell Movement; Cell Proliferation; Chromones; Cyclooxygenase 2; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Inflammation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Morpholines; NF-kappa B; Protein Kinase C-delta; Transcription, Genetic | 2012 |
Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3, MAPK/ERK, and PI3K/AKT signaling pathways.
Topics: Animals; Antibodies, Monoclonal; Calcium; Cell Death; Chromones; Cytokine Receptor gp130; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Interleukin-6; Janus Kinases; MAP Kinase Signaling System; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Up-Regulation | 2013 |
The upregulation of transglutaminase-2 by cyclosporin a in human gingival fibroblasts is augmented by oxidative stress.
Topics: Acetylcysteine; Adult; Antioxidants; Catechin; Cell Culture Techniques; Cells, Cultured; Chromones; Curcumin; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Free Radical Scavengers; Gingiva; GTP-Binding Proteins; Humans; Imidazoles; Immunosuppressive Agents; Male; Morpholines; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protease Inhibitors; Protein Glutamine gamma Glutamyltransferase 2; Pyridines; Reactive Oxygen Species; Transglutaminases; Up-Regulation | 2013 |
(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells.
Topics: Antiviral Agents; Catechin; Cell Line, Tumor; Cell Survival; Chromones; DNA, Viral; Enzyme Activation; Epstein-Barr Virus Infections; Flavonoids; Herpesvirus 4, Human; Humans; Lymphoma; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Nasopharyngeal Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Viral Proteins; Virus Activation | 2013 |
KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin | 2013 |
TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Anthracenes; Cell Line, Tumor; Cell Movement; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioma; High-Throughput Screening Assays; Humans; Imidazoles; Macrophages; MAP Kinase Kinase 4; Morpholines; Neovascularization, Pathologic; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays; Zebrafish | 2013 |
Lipoic acid inhibits adiponectin production in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anthracenes; Chromones; Enzyme Inhibitors; Flavonoids; MAP Kinase Kinase 4; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Ribonucleotides; RNA, Messenger; Thioctic Acid | 2013 |
Ras activated ERK and PI3K pathways differentially affect directional movement of cultured fibroblasts.
Topics: Animals; Cell Line; Cell Movement; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Mice; Morpholines; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; ras Proteins; Signal Transduction; Time-Lapse Imaging | 2013 |
PDGF-BB-induced MT1-MMP expression regulates proliferation and invasion of mesenchymal stem cells in 3-dimensional collagen via MEK/ERK1/2 and PI3K/AKT signaling.
Topics: Animals; Becaplermin; Cell Culture Techniques; Cell Line; Cell Movement; Cell Proliferation; Chromones; Collagen; Flavonoids; Matrix Metalloproteinase 14; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Rats; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction | 2013 |
Increased expression of the antiapoptotic protein MCL1 in canine mast cell tumors.
Topics: Animals; Benzamides; Chromones; Dog Diseases; Dogs; Electrophoresis, Polyacrylamide Gel; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Imatinib Mesylate; Janus Kinases; Mastocytoma; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Piperazines; Pyrimidines; Sirolimus; Tyrphostins | 2013 |
Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo.
Topics: Animals; Blotting, Western; Calcium Chloride; Cell Movement; Cell Proliferation; Chromones; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Nude; Morpholines; Neovascularization, Physiologic; Platelet-Rich Plasma; Statistics, Nonparametric; Thrombin | 2014 |
Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.
Topics: Anthracenes; Chromones; Down-Regulation; Epithelial-Mesenchymal Transition; Flavonoids; HEK293 Cells; Homeodomain Proteins; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Signaling System; Membrane Glycoproteins; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Tight Junctions; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Suppressor Proteins; Zinc Finger E-box-Binding Homeobox 1 | 2013 |
Suppression of apoptosis by pseudorabies virus Us3 protein kinase through the activation of PI3-K/Akt and NF-κB pathways.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Dimethyl Sulfoxide; DNA Damage; Flavonoids; Herpesvirus 1, Suid; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pseudorabies; Signal Transduction; Swine; Viral Proteins; Wortmannin | 2013 |
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins | 2013 |
MAPK and PI3K pathways regulate hypoxia-induced atrial natriuretic peptide secretion by controlling HIF-1 alpha expression in beating rabbit atria.
Topics: Animals; Atrial Natriuretic Factor; Chromones; Female; Flavonoids; Heart Atria; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Male; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Rabbits; Signal Transduction | 2013 |
Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.
Topics: Apoptosis; Chromones; Flavonoids; HL-60 Cells; Humans; Leukemia; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Triterpenes | 2013 |
Cross-talk between integrin receptor and insulin-like growth factor receptor in regulation of collagen biosynthesis in cultured fibroblasts.
Topics: Butadienes; Cell Line; Chromones; Collagen; Dipeptidases; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Integrin beta1; Intercellular Signaling Peptides and Proteins; Morpholines; Nitriles; Peptides; Phosphorylation; Receptor Cross-Talk; Receptor, IGF Type 1; Signal Transduction; Skin; Thrombin | 2013 |
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Chromones; ErbB Receptors; Female; Flavonoids; Hair Follicle; Hyperplasia; Keratinocytes; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred ICR; Mice, Transgenic; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2014 |
Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways.
Topics: Animals; Carcinoma, Hepatocellular; Catheter Ablation; Cell Line, Tumor; Chromones; Disease Progression; Epithelial-Mesenchymal Transition; Flavonoids; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Nude; Morpholines; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt | 2013 |
[Salidroside via ERK1/2 and PI3K/AKT/mTOR signal pathway induces mouse bone marrow mesenchymal stem cells differentiation into neural cells].
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Glial Fibrillary Acidic Protein; Glucosides; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nestin; Neurons; Phenols; Phosphatidylinositol 3-Kinases; Phosphopyruvate Hydratase; Plants, Medicinal; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rhodiola; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Tubulin | 2013 |
LIM kinase 1 is required for insulin‑dependent cell growth of osteosarcoma cell lines.
Topics: Actin Depolymerizing Factors; Cell Line, Tumor; Cell Proliferation; Cholecalciferol; Chromones; Flavonoids; Humans; Insulin; Lim Kinases; Mitogen-Activated Protein Kinases; Morpholines; Osteosarcoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Signal Transduction | 2014 |
Endothelin-1 stimulates resistin gene expression.
Topics: 3T3-L1 Cells; Adipose Tissue; Androstadienes; Animals; Anthracenes; Butadienes; Chromones; Dactinomycin; Endothelin-1; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Morpholines; Nitriles; Oligopeptides; Piperidines; Proto-Oncogene Proteins c-akt; Resistin; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Wortmannin | 2014 |
TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dinoprostone; E1A-Associated p300 Protein; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Humans; Janus Kinase 2; Lung; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A2; Phosphorylation; Pneumonia; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrphostins | 2014 |
Angiotensin II-derived reactive oxygen species promote angiogenesis in human late endothelial progenitor cells through heme oxygenase-1 via ERK1/2 and AKT/PI3K pathways.
Topics: Angiotensin II; Antioxidants; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Endothelial Progenitor Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heme Oxygenase-1; Humans; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering | 2014 |
Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors.
Topics: Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Receptors, Proteinase-Activated; T-Lymphocyte Subsets; Thrombin; Trypsin; Tumor Necrosis Factor-alpha | 2013 |
Betulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt pathways in B16F10 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Betulinic Acid; Cell Line, Tumor; Cell Survival; Chromones; CREB-Binding Protein; Flavonoids; Hyperpigmentation; Interferon Type I; Intramolecular Oxidoreductases; Melanins; Mice; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinase Kinases; Morpholines; Oxidoreductases; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Plant Roots; Pregnancy Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes; Vitis | 2014 |
OVA66, a tumor associated protein, induces oncogenic transformation of NIH3T3 cells.
Topics: Animals; Antigens, Neoplasm; Cell Transformation, Neoplastic; Chromones; Flavonoids; HeLa Cells; Humans; Mice; Morpholines; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
Pentraxin 3 promotes oxLDL uptake and inhibits cholesterol efflux from macrophage-derived foam cells.
Topics: Apolipoprotein A-I; Atherosclerosis; ATP Binding Cassette Transporter 1; C-Reactive Protein; Cell Line, Tumor; Cholesterol; Chromones; Flavonoids; Foam Cells; Gene Expression; Gene Silencing; Humans; Imidazoles; Lipoproteins, LDL; Liver X Receptors; Mitogen-Activated Protein Kinase 3; Morpholines; Orphan Nuclear Receptors; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; PPAR gamma; Pyridines; Serum Amyloid P-Component; Signal Transduction | 2014 |
Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways.
Topics: Animals; Apoptosis; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Caspase 3; Chromones; Enzyme Activation; Flavonoids; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Male; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; Signal Transduction | 2014 |
API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Flavonoids; HCT116 Cells; HeLa Cells; Humans; Imidazoles; Lymphocyte Activation; MCF-7 Cells; Membrane Proteins; Mice; Morpholines; Neoplasms; Nuclear Proteins; Protein Kinase C-delta; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines; Receptor, Fibroblast Growth Factor, Type 1; RNA Interference; Signal Transduction; Tumor Escape | 2014 |
IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
Topics: Animals; Bone Marrow Cells; Brain; Cells, Cultured; Chromones; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Ischemia; Mesenchymal Stem Cells; Mice; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Vascular Endothelial Growth Factor A | 2014 |
SGK1 is involved in cardioprotection of urocortin-1 against hypoxia/reoxygenation in cardiomyocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Gene Knockdown Techniques; Hypoxia; Immediate-Early Proteins; Isoquinolines; Models, Animal; Morpholines; Myocytes, Cardiac; Peptide Fragments; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Real-Time Polymerase Chain Reaction; Receptors, Corticotropin-Releasing Hormone; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sulfonamides; Urocortins | 2014 |
Molecular ties between the cell cycle and differentiation in embryonic stem cells.
Topics: Animals; Cell Cycle; Cell Differentiation; Chromones; Cloning, Molecular; DNA Primers; Embryonic Development; Embryonic Stem Cells; Flavonoids; MAP Kinase Kinase 1; Mice; Microarray Analysis; Morpholines; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Purines; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine | 2014 |
ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Differentiation; Cell Survival; Chromones; Cytochromes c; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Glycyrrhizic Acid; MAP Kinase Signaling System; Mitochondria; Morpholines; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction | 2014 |
Induction of cysteine-rich motor neuron 1 mRNA expression in vascular endothelial cells.
Topics: Bone Morphogenetic Protein Receptors; Cell Culture Techniques; Chromones; Collagen; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesion Kinase 1; Gels; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Membrane Proteins; Morpholines; Neovascularization, Physiologic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Vascular Endothelial Growth Factor A | 2014 |
7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K/Akt and JNK pathways.
Topics: Animals; Apoptosis; Cell Survival; Chromones; Flavones; Flavonoids; MAP Kinase Signaling System; Morpholines; Neuroprotective Agents; Oxidopamine; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats | 2014 |
Anti-apoptotic signal transduction mechanism of electroacupuncture in acute spinal cord injury.
Topics: Animals; Apoptosis; Caspase 3; Chromones; Cytochromes c; Electroacupuncture; Female; Flavonoids; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rabbits; Random Allocation; Signal Transduction; Spinal Cord; Spinal Cord Injuries | 2014 |
PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL.
Topics: Anthracenes; Apoptosis; bcl-X Protein; Caffeic Acids; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Regulation, Developmental; Hematopoiesis; Humans; Macrophage Colony-Stimulating Factor; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; Tetradecanoylphorbol Acetate | 2014 |
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins | 2014 |
IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathway.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chromones; Female; Flavonoids; Hippocampus; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neural Stem Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; POU Domain Factors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation | 2014 |
bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathway.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Chromones; Endoplasmic Reticulum Stress; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Flavonoids; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitochondria; Morpholines; Myocardial Reperfusion Injury; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; tert-Butylhydroperoxide | 2015 |
Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells.
Topics: Adipose Tissue; Alzheimer Disease; Anthracenes; Cell Line, Tumor; Cell Survival; Chromones; Culture Media, Conditioned; Flavonoids; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2015 |
MiR-133b Promotes neurite outgrowth by targeting RhoA expression.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Chromones; Flavonoids; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurites; Neurons; Oligonucleotides, Antisense; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction | 2015 |
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Targeting Drugs in Prostate Cancer.
Topics: Cell Line, Tumor; Cell Survival; Chromones; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Humans; Male; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Tubulin Modulators; Up-Regulation | 2015 |
Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway.
Topics: Cell Line, Transformed; Cell Proliferation; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Lipogenesis; Morpholines; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Resveratrol; Sebaceous Glands; Signal Transduction; Stilbenes | 2015 |
Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol.
Topics: Animals; Cardiotonic Agents; Chromones; Drug Therapy, Combination; Female; Flavonoids; Flavonols; MAP Kinase Signaling System; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Prodrugs; Proto-Oncogene Proteins c-akt; Rats; Sheep; Signal Transduction | 2015 |
A soluble receptor for advanced glycation end-products inhibits myocardial apoptosis induced by ischemia/reperfusion via the JAK2/STAT3 pathway.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Chromones; Flavonoids; Gene Expression; Janus Kinase 2; Male; Mice, Inbred C57BL; Morpholines; Myocardium; Myocytes, Cardiac; Peptide Fragments; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Reperfusion Injury; Signal Transduction; STAT3 Transcription Factor; Tyrphostins | 2015 |
Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus.
Topics: Adult; Case-Control Studies; Cellular Senescence; Chromones; Cytokines; Enzyme Inhibitors; Female; Flavonoids; Humans; Janus Kinases; Leptin; Lupus Erythematosus, Systemic; MAP Kinase Signaling System; Mesenchymal Stem Cells; Morpholines; Peptides; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT Transcription Factors; Tyrphostins; Young Adult | 2015 |
Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells.
Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Disease Models, Animal; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Flavonoids; Male; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Retinal Detachment; Retinal Pigment Epithelium; Signal Transduction | 2015 |
Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.
Topics: Alkaloids; Animals; Bone Marrow Cells; Cell Division; Cells, Cultured; Chromones; Colony-Forming Units Assay; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Inbred CBA; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2015 |
Regulatory Roles of Endogenous Mitogen-Activated Protein Kinases and Tyrosine Kinases in the Pacemaker Activity of Colonic Interstitial Cells of Cajal.
Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin | 2015 |
Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways.
Topics: Aldosterone; Animals; Benzofurans; Calcium; Cell Communication; Cell Line; Cell Proliferation; Chromones; Connexin 43; Flavonoids; Fluorescent Dyes; Gap Junctions; Gene Expression Regulation; Indoles; Isoquinolines; Maleimides; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone | 2015 |
Apelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK and PI3-K/Akt pathways.
Topics: Adult; Alkaline Phosphatase; Aortic Valve; Aortic Valve Stenosis; Apelin; Calcinosis; Cell Differentiation; Cells, Cultured; Chromones; Core Binding Factor Alpha 1 Subunit; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Intercellular Signaling Peptides and Proteins; Morpholines; Muscle, Smooth, Vascular; Osteoblasts; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2015 |
HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-κB activation.
Topics: Acute-Phase Proteins; Cell Line; Cell Proliferation; Chromones; Flavonoids; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Imidazoles; Lipocalin-2; Lipocalins; Matrix Metalloproteinase 9; Morpholines; Neoplasm Metastasis; NF-kappa B; Proto-Oncogene Proteins; Pyridines; Signal Transduction; Stomach Neoplasms | 2015 |
The Interplay of Akt and ERK in Aβ Toxicity and Insulin-Mediated Protection in Primary Hippocampal Cell Culture.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Cells, Cultured; Chromones; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; Insulin; MAP Kinase Signaling System; Morpholines; Nerve Tissue Proteins; Neuroprotective Agents; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphorylation; Primary Cell Culture; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Signal Transduction | 2015 |
[Liraglutide promotes proliferation and migration of cardiac microvascular endothelial cells through PI3K/Akt and MAPK/ERK signaling pathways].
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Endothelial Cells; Flavonoids; Glucagon-Like Peptide 1; Liraglutide; MAP Kinase Signaling System; Morpholines; Myocardium; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley | 2015 |
Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity.
Topics: Animals; Apoptosis; Cerebral Cortex; Chromones; Dose-Response Relationship, Drug; Flavonoids; Hypoxia-Ischemia, Brain; MAP Kinase Signaling System; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neurons; Neuroprotective Agents; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Small Interfering; Transcription Factors; Transcriptional Activation; Up-Regulation | 2015 |
Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions.
Topics: Animals; Chromones; Erythropoiesis; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hematopoietic Stem Cells; Imidazoles; Immunomagnetic Separation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2015 |
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
Topics: Animals; Apelin; Autophagy; Cardiomegaly; Cell Line; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Enzymologic; Intercellular Signaling Peptides and Proteins; Morpholines; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Rats; Ribosomal Protein S6 Kinases, 70-kDa | 2015 |
Aspirin Inhibits LPS-Induced Expression of PI3K/Akt, ERK, NF-κB, CX3CL1, and MMPs in Human Bronchial Epithelial Cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bronchi; Cell Line; Chemokine CX3CL1; Chromones; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Lipopolysaccharides; Matrix Metalloproteinase 12; Matrix Metalloproteinase 7; Matrix Metalloproteinase 9; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrrolidines; Respiratory Mucosa; Thiocarbamates | 2016 |
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cadherins; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Chromones; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Humans; Intercellular Adhesion Molecule-1; Interleukins; Killer Cells, Natural; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Middle Aged; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polycyclic Compounds; Reverse Transcriptase Polymerase Chain Reaction; STAT3 Transcription Factor; Synovial Membrane | 2016 |
GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression.
Topics: Abortion, Legal; Adult; Cell Line, Transformed; Cell Movement; Chorionic Villi; Chromones; Core Binding Factor Alpha 1 Subunit; Decidua; Female; Flavonoids; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; Oligopeptides; Pregnancy; Pregnancy Trimester, First; Primary Cell Culture; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Trophoblasts | 2016 |
Genipin Derivatives Protect RGC-5 from Sodium Nitroprusside-Induced Nitrosative Stress.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chromones; Flavonoids; Gene Expression Regulation; Iridoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Retinal Ganglion Cells; Signal Transduction | 2016 |
Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats.
Topics: Animals; Antidepressive Agents; Chromones; Corticosterone; Depression; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Helplessness, Learned; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Locomotion; Male; Memory Disorders; Morpholines; Rats; Rats, Wistar; Recognition, Psychology; Stress, Psychological; Swimming; Time Factors | 2016 |
Brain-derived neurotrophic factor promotes vesicular glutamate transporter 3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Ganglia, Spinal; GAP-43 Protein; Gene Expression Regulation; MAP Kinase Signaling System; Morpholines; Neuronal Outgrowth; Neurons; Rats; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Statistics, Nonparametric; Trans-Activators; Transcription Factors; Transfection; Vesicular Glutamate Transport Proteins | 2016 |
The study of traditional Chinese medical elongated-needle therapy promoting neurological recovery mechanism after spinal cord injury in rats.
Topics: Acupuncture Therapy; Animals; bcl-2-Associated X Protein; Caspase 3; Chromones; Cytochromes c; Cytokines; Flavonoids; Male; Medicine, Chinese Traditional; Mitogen-Activated Protein Kinases; Morpholines; Needles; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2016 |
The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway.
Topics: Animals; Antipsychotic Agents; Apoptosis; Cell Death; Cell Nucleus; Cell Survival; Chromones; Clozapine; Corticosterone; Cytoprotection; Flavonoids; Forkhead Box Protein O3; Gene Knockdown Techniques; Morpholines; Neuroprotective Agents; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; RNA, Small Interfering; Signal Transduction | 2017 |
Artemisinin conferred ERK mediated neuroprotection to PC12 cells and cortical neurons exposed to sodium nitroprusside-induced oxidative insult.
Topics: Animals; Artemisinins; Cell Death; Cell Survival; Chromones; Flavonoids; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Morpholines; Nerve Degeneration; Neurons; Neuroprotection; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; PC12 Cells; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction | 2016 |
H4R activation utilizes distinct signaling pathways for the production of RANTES and IL-13 in human mast cells.
Topics: Chemokine CCL5; Chromones; Flavonoids; Gene Expression Regulation; Histamine; Histamine Antagonists; Humans; Interleukin-13; MAP Kinase Signaling System; Mast Cells; Methylhistamines; Morpholines; NF-kappa B; Oncogene Protein v-akt; Phosphorylation; Receptors, Histamine | 2017 |
Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies.
Topics: Androstadienes; Animals; Carrier Proteins; Chromones; Citrulline; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Malnutrition; Mechanistic Target of Rapamycin Complex 1; Mitogen-Activated Protein Kinases; Morpholines; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2017 |
Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.
Topics: Anemia; Animals; Bone Marrow Cells; Chromones; Disease Models, Animal; Erythropoiesis; Erythropoietin; Flavonoids; Gene Expression Regulation; Hemorrhage; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2016 |
Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Chromones; Flavonoids; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Imidazoles; Insulin-Like Growth Factor I; Melanoma; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcriptional Activation; Uveal Neoplasms | 2016 |
Repurposing ospemifene for potentiating an antigen-specific immune response.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Calmodulin; Cancer Vaccines; Carcinogenesis; Chromones; Cytokines; Drug Administration Schedule; Drug Repositioning; Female; Flavonoids; Gene Expression; Humans; Immunologic Factors; Interferon-gamma; Interleukin-2; Jurkat Cells; Lung Neoplasms; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Transgenic; Morpholines; Mucin-1; Phosphatidylinositol 3-Kinases; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tamoxifen; Trifluoperazine | 2017 |
Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation.
Topics: Animals; Butadienes; Cell Differentiation; Cell Proliferation; Chromones; Cyclic AMP-Dependent Protein Kinases; Embryo, Mammalian; Epithelial Cells; Epithelial-Mesenchymal Transition; Fixatives; Flavonoids; Formaldehyde; Gene Expression Regulation, Developmental; Isoquinolines; Ki-67 Antigen; Mice; Mice, Inbred ICR; Morpholines; Nitriles; Organ Culture Techniques; Paraffin Embedding; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polymers; Signal Transduction; Sulfonamides; Tongue | 2017 |
Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination.
Topics: A549 Cells; Animals; Cell Line, Tumor; Chromones; Down-Regulation; Epithelial-Mesenchymal Transition; Flavonoids; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Snail Family Transcription Factors; Ubiquitin-Protein Ligases; Ubiquitination | 2017 |
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromones; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drugs, Chinese Herbal; Enzyme Inhibitors; Epimedium; Female; Flavonoids; MAP Kinase Signaling System; Mice, Inbred C57BL; Morpholines; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinase; Phosphorylation; Phytotherapy; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine 3-Monooxygenase | 2017 |
Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.
Topics: Animals; Axons; Bone Marrow Cells; Cells, Cultured; Cerebral Hemorrhage; Chromones; Disease Models, Animal; Flavonoids; GAP-43 Protein; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Regeneration; Signal Transduction; Up-Regulation | 2017 |
Dual hypopigmentary effects of punicalagin via the ERK and Akt pathways.
Topics: Animals; Antioxidants; Cell Line, Transformed; Chromones; Enzyme Inhibitors; Flavonoids; Hydrolyzable Tannins; Hypopigmentation; Kinetics; MAP Kinase Signaling System; Melanins; Melanocytes; Mice; Microphthalmia-Associated Transcription Factor; Microscopy, Phase-Contrast; Monophenol Monooxygenase; Morpholines; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt | 2017 |
Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells.
Topics: Animals; Cells, Cultured; Chromones; Collagen Type III; Connective Tissue Growth Factor; Fibronectins; Flavonoids; Gene Expression; Gene Expression Regulation; Male; MAP Kinase Signaling System; Models, Animal; Morpholines; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats, Sprague-Dawley | 2017 |
Protective properties of Huperzine A through activation Nrf2/ARE-mediated transcriptional response in X-rays radiation-induced NIH3T3 cells.
Topics: Alkaloids; Animals; Antioxidant Response Elements; Apoptosis; Catalase; Cell Cycle; Chromones; Flavonoids; Gene Expression Regulation; Glutathione Peroxidase; Imidazoles; Kelch-Like ECH-Associated Protein 1; Lipid Peroxides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-E2-Related Factor 2; NIH 3T3 Cells; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Radiation-Protective Agents; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Superoxide Dismutase; X-Rays | 2018 |
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Disease Progression; Dose-Response Relationship, Drug; Female; Flavonoids; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Morpholines; Myeloid Cells; Philadelphia Chromosome; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Treatment Outcome; Vascular Endothelial Growth Factor A | 2018 |
Specific effects of neuregulin-1β on the communication between DRG neurons and skeletal muscle cells in vitro.
Topics: Animals; Chromones; Coculture Techniques; Flavonoids; Ganglia, Spinal; MAP Kinase Signaling System; Morpholines; Muscle Proteins; Muscle, Skeletal; Neuregulin-1; Rats; Rats, Wistar; Sensory Receptor Cells; Tyrphostins | 2018 |
Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Curcumin; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glucose; Humans; Hyperglycemia; Morpholines; Neoplasm Invasiveness; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction | 2019 |
Role of Signaling Molecules in the Regulation of Granulocytopoiesis during Stress-Inducing Stimulation.
Topics: Animals; Bone Marrow Cells; Chromones; Flavonoids; Gene Expression Regulation; Gold Sodium Thiomalate; Granulocyte Colony-Stimulating Factor; Granulocytes; Imidazoles; Immobilization; Leukopoiesis; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Psychological | 2019 |
RRM2 is a potential prognostic biomarker with functional significance in glioma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Flavonoids; Flow Cytometry; Glioma; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Mice; Mice, Nude; Morpholines; Ribonucleoside Diphosphate Reductase; Wound Healing | 2019 |
Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cerebral Cortex; Chromones; Cortical Excitability; Electric Stimulation; Flavonoids; GABAergic Neurons; Glucose; Inhibitory Postsynaptic Potentials; Janus Kinase 2; Leptin; Mitogen-Activated Protein Kinase Kinases; Morpholines; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Pyrazoles; Pyrimidines; Rats; Rats, Transgenic; Rotenone; Signal Transduction; Synaptic Transmission; Wortmannin | 2019 |
ZEB1 protects skeletal muscle from damage and is required for its regeneration.
Topics: Animals; Chemokine CCL2; Chromones; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Laminin; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle, Skeletal; Muscular Dystrophies; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Regeneration; RNA, Messenger; Satellite Cells, Skeletal Muscle; Signal Transduction; Zinc Finger E-box-Binding Homeobox 1 | 2019 |
Decellularized and solubilized pancreatic stroma promotes the in vitro proliferation, migration and differentiation of BMSCs into IPCs.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glucose; Homeodomain Proteins; Insulin; Islets of Langerhans; Mesenchymal Stem Cells; Morpholines; Pancreas; Rats; Rats, Sprague-Dawley; Regenerative Medicine; Signal Transduction; Tissue Scaffolds; Trans-Activators | 2019 |
Bisdemethoxycurcumin Protection of Cardiomyocyte Mainly Depends on Nrf2/HO-1 Activation Mediated by the PI3K/AKT Pathway.
Topics: Animals; Apoptosis; Cardiotonic Agents; Chromones; Diarylheptanoids; Flavonoids; Heme Oxygenase-1; Membrane Proteins; Mice; Morpholines; Myocytes, Cardiac; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Up-Regulation | 2019 |
Euscaphic acid and Tormentic acid protect vascular endothelial cells against hypoxia-induced apoptosis via PI3K/AKT or ERK 1/2 signaling pathway.
Topics: Apoptosis; Cell Hypoxia; Cell Line; Chromones; Endothelial Cells; Flavonoids; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinase; Potentilla; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes | 2020 |
Alteration in the expression of inflammatory cytokines in primary hippocampal astrocytes in response to MK-801 through ERK1/2 and PI3K signals.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Proliferation; Chromones; Cytokines; Dizocilpine Maleate; Flavonoids; Hippocampus; Inflammation; Interleukin-1beta; Interleukin-6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
The Effects of Insulin on Immortalized Rat Schwann Cells, IFRS1.
Topics: Animals; Cell Division; Cell Line, Transformed; Chromones; Diabetic Neuropathies; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Insulin; Mitogen-Activated Protein Kinase Kinases; Morpholines; Myelin Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; Receptor, Insulin; Schwann Cells; Signal Transduction | 2021 |
HGF-mediated Up-regulation of PHLDA2 Is Associated With Apoptosis in Gastric Cancer.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hepatocyte Growth Factor; Humans; Imidazoles; Morpholines; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Pyridines; Stomach Neoplasms; Up-Regulation | 2021 |
Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Movement; Chemokines; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Male; Morpholines; Myocardium; Naphthalenes; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quaternary Ammonium Compounds; Rats, Wistar; Reactive Oxygen Species; Receptors, Chemokine | 2021 |
Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis.
Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cell Survival; Chromones; Concanavalin A; Cyclin D1; Dose-Response Relationship, Drug; Flavonoids; Hindlimb; Human Umbilical Vein Endothelial Cells; Humans; Ischemia; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Morpholines; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt | 2022 |