Page last updated: 2024-09-03

pd 81723 and thiophenes

pd 81723 has been researched along with thiophenes in 36 studies

Compound Research Comparison

Studies (pd 81723)	Trials (pd 81723)	Recent Studies (post-2010) (pd 81723)	Studies (thiophenes)	Trials (thiophenes)	Recent Studies (post-2010) (thiophenes)
55	0	12	17,012	1,961	8,038

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (52.78)	18.2507
2000's	12 (33.33)	29.6817
2010's	5 (13.89)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berman, RF; Bruns, RF; Janusz, CA	1
Eglen, RM; Flippin, LA; Kim, EJ; Lazar, DA; Leung, E; Seran, CS; Walsh, LK; Wong, EH	1
Bhattacharya, S; Linden, J	2
Belardinelli, L; Bruns, RF; Dennis, D; Kollias-Baker, C; Linden, J; Ruble, J	1
Belardinelli, L; Kollias-Baker, C; Pelleg, A; Xu, J	1
Amoah-Apraku, B; Belardinelli, L; Bruns, RF; Lu, JY; Pelleg, A; Xu, J	1
Berman, RF; Janusz, CA	1
Bruns, RF; Montamat, SC; Mudumbi, RV; Vestal, RE	1
Daly, JW; Moni, RW; Romero, FS	1
Cao, X; Phillis, JW	1
Auchampach, JA; Bruns, RF; Gross, GJ; Linden, J; Mizumura, T	1
Belardinelli, L; Dennis, DM; Martens, JR; Raatikainen, MJ	1
Belardinelli, L; Harrison, JK; Jacobson, M; Kollias-Baker, CA; Ozeck, M; Ruble, J; Shryock, JC	1
Brandts, B; Bünemann, M; Hluchy, J; Pott, L; Sabin, GV	1
Liu, J; Mudumbi, RV; Musser, B; Olson, RD; Vestal, RE	1
Richardt, G; Schreieck, J	1
IJzerman, AP; Kourounakis, AP; van der Klein, PA	1
Cox, BF; Gessner, G; Jarvis, MF; Martin, GE; Merkel, L; Myers, M; Shapiro, G	1
Baraldi, PG; Fruttarolo, F; Lampronti, I; Leung, E; Pavani, MG; Romagnoli, R; Shryock, JC; Tabrizi, MA; Zaid, AN	1
de Groote, M; IJzerman, AP; Kourounakis, A; Visser, C	1
Belardinelli, L; Dennis, DM; Martynyuk, AE; Morey, TE; Seubert, CN; Zima, A	1
Bueters, TJ; Danhof, M; IJzerman, AP; van Helden, HP	1
Cambray, AJ; D'Ambrosio, R; Higashi, H; Meno, JR; Winn, HR; Zhou, J	1
Chordia, MD; Joshi, E; Linden, J; Macdonald, TL; Olsson, R	1
de Ligt, RA; IJzerman, AP; Klaasse, E; Leurs, R; Lorenzen, A; Milligan, G; Roerink, SF	1
de Ligt, RA; IJzerman, AP; Leurs, R; Lorenzen, A; Rivkees, SA	1
Halenda, SP; Shen, J; Sturek, M; Wilden, PA	1
Beukers, MW; de Grip, WJ; Ijzerman, AP; Klaasse, EC; Roerink, SF; van den Hout, G	1
Bhattacharya, S; Ghartey, K; Leonard, M; Linden, J; Tucker, AL; Youkey, RL	1
Baker, SP; Baraldi, PG; Borea, PA; Cara, CL; Carrion, MD; Fruttarolo, F; Iaconinoto, MA; Moorman, AR; Preti, D; Romagnoli, R; Tabrizi, MA; Varani, K	1
Brussee, J; Doddareddy, M; Ijzerman, AP; Lane, JR; Lin, J; Narlawar, R	1
Bianucci, AM; Borghini, A; Breschi, MC; Pietra, D	1
Dinaj, A; Ijzerman, AP; Peeters, MC; Vriend, G; Vroling, B; Wisse, LE	1
Brown, KM; D'Agati, VD; Ham, A; Kim, JY; Kim, M; Lee, HT; Park, SW	1
Baraldi, PG; Borea, PA; Gessi, S; Merighi, S; Romagnoli, R; Targa, M; Varani, K; Vincenzi, F	1

Other Studies

36 other study(ies) available for pd 81723 and thiophenes

Article	Year
Functional activity of the adenosine binding enhancer, PD 81,723, in the in vitro hippocampal slice. Brain research, 1991, Dec-20, Volume: 567, Issue:2 Topics: Adenosine; Animals; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Neural Pathways; Neurons; Pyramidal Tracts; Rats; Receptors, Purinergic; Thiophenes	1991
Enhancement of adenosine A1 receptor functions by benzoylthiophenes in guinea pig tissues in vitro. Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:2 Topics: Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Electric Stimulation; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Contraction; Myocardial Contraction; Peptides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Ribonucleosides; Thienopyridines; Thiophenes; Wasp Venoms	1995
The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins. Biochimica et biophysica acta, 1995, Feb-16, Volume: 1265, Issue:1 Topics: Allosteric Regulation; Animals; Cell Membrane; CHO Cells; Cricetinae; GTP-Binding Proteins; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes	1995
Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. Circulation research, 1994, Volume: 75, Issue:6 Topics: Adenosine; Allosteric Regulation; Animals; Binding Sites; Brain; Bundle of His; Drug Synergism; Female; Guinea Pigs; Heart; Humans; In Vitro Techniques; Male; Membranes; Myocardium; Piperazines; Radioligand Assay; Receptors, Purinergic P1; Thiophenes	1994
Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine. Circulation research, 1994, Volume: 75, Issue:6 Topics: Adenosine; Animals; Atrioventricular Node; Bundle of His; Coronary Vessels; Female; Guinea Pigs; Hypoxia; In Vitro Techniques; Male; Piperazines; Receptors, Purinergic P1; Thiophenes; Tubercidin; Vasodilation	1994
Selective potentiation by an A1 adenosine receptor enhancer of the negative dromotropic action of adenosine in the guinea pig heart. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2 Topics: Adenosine; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; Female; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Receptors, Purinergic; Thiophenes	1993
The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice. Brain research, 1993, Aug-13, Volume: 619, Issue:1-2 Topics: Adenosine; Animals; Axons; Electric Stimulation; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; Neurons; Pyramidal Tracts; Rats; Thiophenes	1993
Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor. The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 2 Topics: Adenosine; Allosteric Regulation; Animals; Atrial Function; Depression, Chemical; Drug Synergism; Heart; Heart Atria; Heart Rate; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Theophylline; Thiophenes; Xanthines	1993
The amphiphilic peptide adenoregulin enhances agonist binding to A1-adenosine receptors and [35S]GTP gamma S to brain membranes. Cellular and molecular neurobiology, 1995, Volume: 15, Issue:4 Topics: Adenosine; Adrenergic alpha-Agonists; Amphibian Proteins; Animals; Antimicrobial Cationic Peptides; Brain; Cell Line; Cell Membrane; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Magnesium Chloride; Peptides; Purinergic P1 Receptor Agonists; Ranidae; Rats; Receptors, Purinergic P1; Sodium Chloride; Sulfur Radioisotopes; Thiophenes; Tritium; Xanthines	1995
Adenosine A1 receptor enhancer, PD 81,723, and cerebral ischemia/reperfusion injury in the gerbil. General pharmacology, 1995, Volume: 26, Issue:7 Topics: Animals; Brain Ischemia; Gerbillinae; Male; Receptors, Purinergic P1; Reperfusion Injury; Thiophenes	1995
Effects of long-term treatment with the allosteric enhancer, PD81,723, on Chinese hamster ovary cells expressing recombinant human A1 adenosine receptors. Molecular pharmacology, 1996, Volume: 50, Issue:1 Topics: Adenosine; Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Kinetics; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes; Transfection	1996
PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circulation research, 1996, Volume: 79, Issue:3 Topics: Allosteric Regulation; Animals; Binding, Competitive; Differential Threshold; Dogs; Female; Glyburide; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion; Radioligand Assay; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes	1996
Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart. Circulation, 1996, Nov-15, Volume: 94, Issue:10 Topics: Adenosine; Allosteric Regulation; Animals; Atrioventricular Node; Biological Transport; Body Fluids; Enzyme Inhibitors; Guinea Pigs; Heart; Heart Conduction System; In Vitro Techniques; Myocardium; Nucleosides; Pericardium; Piperazines; Platelet Aggregation Inhibitors; Thiophenes; Tubercidin	1996
Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2 Topics: Adenosine; Adenosine Deaminase; Allosteric Regulation; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes; Xanthines	1997
Inhibition of muscarinic K+ current in guinea-pig atrial myocytes by PD 81,723, an allosteric enhancer of adenosine binding to A1 receptors. British journal of pharmacology, 1997, Volume: 121, Issue:6 Topics: Adenosine; Allosteric Regulation; Animals; Cells, Cultured; Female; Guinea Pigs; Heart Atria; Male; Potassium Channel Blockers; Receptors, Muscarinic; Receptors, Purinergic P1; Thiophenes	1997
Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2 Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adjuvants, Immunologic; Animals; Brain; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cyclic AMP; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Kinetics; Magnesium; Membranes; Pertussis Toxin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptors, Purinergic P1; Stimulation, Chemical; Thiophenes; Transfection; Virulence Factors, Bordetella	1999
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1 Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines	1999
Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding. Journal of medicinal chemistry, 1999, Sep-09, Volume: 42, Issue:18 Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; Brain; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Thiophenes; Xanthines	1999
Differential effects of the adenosine A(1) receptor allosteric enhancer PD 81,723 on agonist binding to brain and adipocyte membranes. Brain research, 1999, Sep-04, Volume: 840, Issue:1-2 Topics: Adenosine; Adipocytes; Allosteric Regulation; Animals; Brain; Dogs; Guinea Pigs; Kinetics; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Thiophenes	1999
Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor. Bioorganic & medicinal chemistry letters, 2000, Sep-04, Volume: 10, Issue:17 Topics: Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cyclic AMP; Humans; Receptors, Purinergic P1; Structure-Activity Relationship; Thiophenes	2000
Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor. Biochemical pharmacology, 2001, Jan-15, Volume: 61, Issue:2 Topics: Alanine; Allosteric Regulation; Binding, Competitive; Cells, Cultured; Cyclic AMP; Humans; Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Thiophenes; Threonine	2001
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism. Basic research in cardiology, 2002, Volume: 97, Issue:4 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Atrioventricular Node; Drug Synergism; Electric Stimulation; Guinea Pigs; Heart Rate; Membrane Potentials; Myocytes, Cardiac; Potassium; Potassium Channels; Thiophenes	2002
Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release. European journal of pharmacology, 2002, Nov-15, Volume: 454, Issue:2-3 Topics: Acetylcholine; Allosteric Regulation; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Thiophenes	2002
Hippocampal injury and neurobehavioral deficits are improved by PD 81,723 following hyperglycemic cerebral ischemia. Experimental neurology, 2003, Volume: 183, Issue:1 Topics: Animals; Behavior, Animal; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Hyperglycemia; Ischemic Attack, Transient; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P1; Thiophenes	2003
Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO. Bioorganic & medicinal chemistry letters, 2004, Feb-23, Volume: 14, Issue:4 Topics: Dimethyl Sulfoxide; Molecular Structure; Oxidation-Reduction; Thiophenes	2004
Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi alpha-subunits. European journal of pharmacology, 2004, Sep-19, Volume: 499, Issue:1-2 Topics: Adenosine; Allosteric Site; Animals; Binding, Competitive; Cell Membrane; COS Cells; Cysteine; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mutation; Radioligand Assay; Receptor, Adenosine A1; Recombinant Fusion Proteins; Sodium Chloride; Sulfur Radioisotopes; Thiophenes; Transfection; Tritium; Xanthines	2004
A "locked-on," constitutively active mutant of the adenosine A1 receptor. European journal of pharmacology, 2005, Mar-07, Volume: 510, Issue:1-2 Topics: Adenosine; Animals; Binding, Competitive; Cell Line; Cell Membrane; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Mutation; Plasmids; Radioligand Assay; Receptor, Adenosine A1; Sodium; Sulfur Radioisotopes; Theophylline; Thiophenes; Transfection; Tritium; Xanthines	2005
Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor. Circulation research, 2005, May-13, Volume: 96, Issue:9 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Amino Acid Sequence; Animals; Cell Proliferation; Cells, Cultured; Cloning, Molecular; Coronary Vessels; DNA; Mitogens; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Organ Culture Techniques; Pertussis Toxin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptors, Purinergic P1; RNA, Messenger; Sus scrofa; Thiophenes	2005
Allosteric modulators affect the internalization of human adenosine A1 receptors. European journal of pharmacology, 2005, Oct-17, Volume: 522, Issue:1-3 Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Endocytosis; Humans; Luminescent Proteins; Microscopy, Confocal; Radioligand Assay; Receptor, Adenosine A1; Recombinant Fusion Proteins; Thiadiazoles; Thiazoles; Thiophenes; Transfection; Tritium; Xanthines	2005
The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs. The Biochemical journal, 2006, May-15, Volume: 396, Issue:1 Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Allosteric Regulation; Animals; Cell Line; Cyclic AMP; Dogs; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Iodobenzenes; Kidney; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Radioligand Assay; Receptor, Adenosine A1; Receptor, Adenosine A2A; Recombinant Fusion Proteins; Thiophenes; Transfection; Xanthines	2006
Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor. Bioorganic & medicinal chemistry letters, 2006, Nov-01, Volume: 16, Issue:21 Topics: Allosteric Regulation; Microwaves; Pyridines; Receptor, Adenosine A1; Thiophenes	2006
Hybrid ortho/allosteric ligands for the adenosine A(1) receptor. Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8 Topics: Adenosine; Adenosine A1 Receptor Agonists; Allosteric Site; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Molecular; Phosphorylation; Radioligand Assay; Receptor, Adenosine A1; Structure-Activity Relationship; Thiophenes	2010
Enhancer and competitive allosteric modulation model for G-protein-coupled receptors. Journal of theoretical biology, 2010, Dec-21, Volume: 267, Issue:4 Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Biological Assay; Computer Simulation; Kinetics; Models, Biological; Radioligand Assay; Rats; Receptor, Adenosine A1; Receptors, G-Protein-Coupled; Thermodynamics; Thiophenes	2010
The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation. Biochemical pharmacology, 2012, Jul-01, Volume: 84, Issue:1 Topics: Alanine; Allosteric Regulation; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Glutamic Acid; Humans; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Receptor, Adenosine A1; Saccharomyces cerevisiae; Sequence Alignment; Thiophenes; Tryptophan	2012
A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. American journal of physiology. Renal physiology, 2012, Volume: 303, Issue:5 Topics: Acute Kidney Injury; Animals; Apoptosis; Cells, Cultured; Humans; Kidney; Kidney Tubules, Proximal; Male; Mice; Phosphotransferases (Alcohol Group Acceptor); Receptor, Adenosine A1; Receptors, Lysosphingolipid; Reperfusion Injury; Thiophenes; Xanthines	2012
TRR469, a potent A(1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice. Neuropharmacology, 2014, Volume: 81 Topics: Acetic Acid; Allosteric Regulation; Analgesics; Animals; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Piperazines; Protein Binding; Purinergic Agents; Thiophenes	2014