pd 81723 has been researched along with n(6)-cyclopentyladenosine in 9 studies
| Studies (pd 81723) | Trials (pd 81723) | Recent Studies (post-2010) (pd 81723) | Studies (n(6)-cyclopentyladenosine) | Trials (n(6)-cyclopentyladenosine) | Recent Studies (post-2010) (n(6)-cyclopentyladenosine) |
|---|---|---|---|---|---|
| 55 | 0 | 12 | 605 | 0 | 62 |
| Protein | Taxonomy | pd 81723 (IC50) | n(6)-cyclopentyladenosine (IC50) |
|---|---|---|---|
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | 0.2256 | |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | 1.16 | |
| Adenosine receptor A1 | Homo sapiens (human) | 0.0027 | |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | 1.16 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eglen, RM; Flippin, LA; Kim, EJ; Lazar, DA; Leung, E; Seran, CS; Walsh, LK; Wong, EH | 1 |
| Bruns, RF; Montamat, SC; Mudumbi, RV; Vestal, RE | 1 |
| Bhattacharya, S; Linden, J | 1 |
| IJzerman, AP; Kourounakis, AP; van der Klein, PA | 1 |
| de Ligt, RA; IJzerman, AP; Klaasse, E; Leurs, R; Lorenzen, A; Milligan, G; Roerink, SF | 1 |
| de Ligt, RA; IJzerman, AP; Leurs, R; Lorenzen, A; Rivkees, SA | 1 |
| Halenda, SP; Shen, J; Sturek, M; Wilden, PA | 1 |
| Beukers, MW; de Grip, WJ; Ijzerman, AP; Klaasse, EC; Roerink, SF; van den Hout, G | 1 |
| Bhattacharya, S; Ghartey, K; Leonard, M; Linden, J; Tucker, AL; Youkey, RL | 1 |
9 other study(ies) available for pd 81723 and n(6)-cyclopentyladenosine
| Article | Year |
|---|---|
Enhancement of adenosine A1 receptor functions by benzoylthiophenes in guinea pig tissues in vitro.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Electric Stimulation; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Contraction; Myocardial Contraction; Peptides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Ribonucleosides; Thienopyridines; Thiophenes; Wasp Venoms | 1995 |
Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor.
Topics: Adenosine; Allosteric Regulation; Animals; Atrial Function; Depression, Chemical; Drug Synergism; Heart; Heart Atria; Heart Rate; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Theophylline; Thiophenes; Xanthines | 1993 |
Effects of long-term treatment with the allosteric enhancer, PD81,723, on Chinese hamster ovary cells expressing recombinant human A1 adenosine receptors.
Topics: Adenosine; Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Kinetics; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes; Transfection | 1996 |
Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; Brain; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Thiophenes; Xanthines | 1999 |
Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi alpha-subunits.
Topics: Adenosine; Allosteric Site; Animals; Binding, Competitive; Cell Membrane; COS Cells; Cysteine; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mutation; Radioligand Assay; Receptor, Adenosine A1; Recombinant Fusion Proteins; Sodium Chloride; Sulfur Radioisotopes; Thiophenes; Transfection; Tritium; Xanthines | 2004 |
A "locked-on," constitutively active mutant of the adenosine A1 receptor.
Topics: Adenosine; Animals; Binding, Competitive; Cell Line; Cell Membrane; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Mutation; Plasmids; Radioligand Assay; Receptor, Adenosine A1; Sodium; Sulfur Radioisotopes; Theophylline; Thiophenes; Transfection; Tritium; Xanthines | 2005 |
Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Amino Acid Sequence; Animals; Cell Proliferation; Cells, Cultured; Cloning, Molecular; Coronary Vessels; DNA; Mitogens; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Organ Culture Techniques; Pertussis Toxin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptors, Purinergic P1; RNA, Messenger; Sus scrofa; Thiophenes | 2005 |
Allosteric modulators affect the internalization of human adenosine A1 receptors.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Endocytosis; Humans; Luminescent Proteins; Microscopy, Confocal; Radioligand Assay; Receptor, Adenosine A1; Recombinant Fusion Proteins; Thiadiazoles; Thiazoles; Thiophenes; Transfection; Tritium; Xanthines | 2005 |
The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Allosteric Regulation; Animals; Cell Line; Cyclic AMP; Dogs; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Iodobenzenes; Kidney; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Radioligand Assay; Receptor, Adenosine A1; Receptor, Adenosine A2A; Recombinant Fusion Proteins; Thiophenes; Transfection; Xanthines | 2006 |