pd 81723 has been researched along with adenosine in 22 studies
| Studies (pd 81723) | Trials (pd 81723) | Recent Studies (post-2010) (pd 81723) | Studies (adenosine) | Trials (adenosine) | Recent Studies (post-2010) (adenosine) |
|---|---|---|---|---|---|
| 55 | 0 | 12 | 32,536 | 1,075 | 8,930 |
| Protein | Taxonomy | pd 81723 (IC50) | adenosine (IC50) |
|---|---|---|---|
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | 0.3851 | |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | 5.5 | |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | 5.5 | |
| Adenosine receptor A3 | Homo sapiens (human) | 0.0011 | |
| Adenosine receptor A1 | Homo sapiens (human) | 0.0023 | |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | 63 | |
| Solute carrier family 28 member 3 | Homo sapiens (human) | 3.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (68.18) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berman, RF; Bruns, RF; Janusz, CA | 1 |
| Eglen, RM; Flippin, LA; Kim, EJ; Lazar, DA; Leung, E; Seran, CS; Walsh, LK; Wong, EH | 1 |
| Belardinelli, L; Bruns, RF; Dennis, D; Kollias-Baker, C; Linden, J; Ruble, J | 1 |
| Belardinelli, L; Kollias-Baker, C; Pelleg, A; Xu, J | 1 |
| Amoah-Apraku, B; Belardinelli, L; Bruns, RF; Lu, JY; Pelleg, A; Xu, J | 1 |
| Berman, RF; Janusz, CA | 1 |
| Bruns, RF; Montamat, SC; Mudumbi, RV; Vestal, RE | 1 |
| Daly, JW; Moni, RW; Romero, FS | 1 |
| Bhattacharya, S; Linden, J | 1 |
| Belardinelli, L; Dennis, DM; Martens, JR; Raatikainen, MJ | 1 |
| Belardinelli, L; Harrison, JK; Jacobson, M; Kollias-Baker, CA; Ozeck, M; Ruble, J; Shryock, JC | 1 |
| Brandts, B; Bünemann, M; Hluchy, J; Pott, L; Sabin, GV | 1 |
| Richardt, G; Schreieck, J | 1 |
| IJzerman, AP; Kourounakis, AP; van der Klein, PA | 1 |
| Cox, BF; Gessner, G; Jarvis, MF; Martin, GE; Merkel, L; Myers, M; Shapiro, G | 1 |
| Belardinelli, L; Dennis, DM; Martynyuk, AE; Morey, TE; Seubert, CN; Zima, A | 1 |
| de Ligt, RA; IJzerman, AP; Klaasse, E; Leurs, R; Lorenzen, A; Milligan, G; Roerink, SF | 1 |
| de Ligt, RA; IJzerman, AP; Leurs, R; Lorenzen, A; Rivkees, SA | 1 |
| Halenda, SP; Shen, J; Sturek, M; Wilden, PA | 1 |
| Beukers, MW; de Grip, WJ; Ijzerman, AP; Klaasse, EC; Roerink, SF; van den Hout, G | 1 |
| Bhattacharya, S; Ghartey, K; Leonard, M; Linden, J; Tucker, AL; Youkey, RL | 1 |
| Brussee, J; Doddareddy, M; Ijzerman, AP; Lane, JR; Lin, J; Narlawar, R | 1 |
22 other study(ies) available for pd 81723 and adenosine
| Article | Year |
|---|---|
Functional activity of the adenosine binding enhancer, PD 81,723, in the in vitro hippocampal slice.
Topics: Adenosine; Animals; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Neural Pathways; Neurons; Pyramidal Tracts; Rats; Receptors, Purinergic; Thiophenes | 1991 |
Enhancement of adenosine A1 receptor functions by benzoylthiophenes in guinea pig tissues in vitro.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Electric Stimulation; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Contraction; Myocardial Contraction; Peptides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Ribonucleosides; Thienopyridines; Thiophenes; Wasp Venoms | 1995 |
Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine.
Topics: Adenosine; Allosteric Regulation; Animals; Binding Sites; Brain; Bundle of His; Drug Synergism; Female; Guinea Pigs; Heart; Humans; In Vitro Techniques; Male; Membranes; Myocardium; Piperazines; Radioligand Assay; Receptors, Purinergic P1; Thiophenes | 1994 |
Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine.
Topics: Adenosine; Animals; Atrioventricular Node; Bundle of His; Coronary Vessels; Female; Guinea Pigs; Hypoxia; In Vitro Techniques; Male; Piperazines; Receptors, Purinergic P1; Thiophenes; Tubercidin; Vasodilation | 1994 |
Selective potentiation by an A1 adenosine receptor enhancer of the negative dromotropic action of adenosine in the guinea pig heart.
Topics: Adenosine; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; Female; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Receptors, Purinergic; Thiophenes | 1993 |
The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice.
Topics: Adenosine; Animals; Axons; Electric Stimulation; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; Neurons; Pyramidal Tracts; Rats; Thiophenes | 1993 |
Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor.
Topics: Adenosine; Allosteric Regulation; Animals; Atrial Function; Depression, Chemical; Drug Synergism; Heart; Heart Atria; Heart Rate; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Theophylline; Thiophenes; Xanthines | 1993 |
The amphiphilic peptide adenoregulin enhances agonist binding to A1-adenosine receptors and [35S]GTP gamma S to brain membranes.
Topics: Adenosine; Adrenergic alpha-Agonists; Amphibian Proteins; Animals; Antimicrobial Cationic Peptides; Brain; Cell Line; Cell Membrane; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Magnesium Chloride; Peptides; Purinergic P1 Receptor Agonists; Ranidae; Rats; Receptors, Purinergic P1; Sodium Chloride; Sulfur Radioisotopes; Thiophenes; Tritium; Xanthines | 1995 |
Effects of long-term treatment with the allosteric enhancer, PD81,723, on Chinese hamster ovary cells expressing recombinant human A1 adenosine receptors.
Topics: Adenosine; Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Kinetics; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes; Transfection | 1996 |
Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart.
Topics: Adenosine; Allosteric Regulation; Animals; Atrioventricular Node; Biological Transport; Body Fluids; Enzyme Inhibitors; Guinea Pigs; Heart; Heart Conduction System; In Vitro Techniques; Myocardium; Nucleosides; Pericardium; Piperazines; Platelet Aggregation Inhibitors; Thiophenes; Tubercidin | 1996 |
Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor.
Topics: Adenosine; Adenosine Deaminase; Allosteric Regulation; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes; Xanthines | 1997 |
Inhibition of muscarinic K+ current in guinea-pig atrial myocytes by PD 81,723, an allosteric enhancer of adenosine binding to A1 receptors.
Topics: Adenosine; Allosteric Regulation; Animals; Cells, Cultured; Female; Guinea Pigs; Heart Atria; Male; Potassium Channel Blockers; Receptors, Muscarinic; Receptors, Purinergic P1; Thiophenes | 1997 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines | 1999 |
Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; Brain; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Thiophenes; Xanthines | 1999 |
Differential effects of the adenosine A(1) receptor allosteric enhancer PD 81,723 on agonist binding to brain and adipocyte membranes.
Topics: Adenosine; Adipocytes; Allosteric Regulation; Animals; Brain; Dogs; Guinea Pigs; Kinetics; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Thiophenes | 1999 |
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Atrioventricular Node; Drug Synergism; Electric Stimulation; Guinea Pigs; Heart Rate; Membrane Potentials; Myocytes, Cardiac; Potassium; Potassium Channels; Thiophenes | 2002 |
Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi alpha-subunits.
Topics: Adenosine; Allosteric Site; Animals; Binding, Competitive; Cell Membrane; COS Cells; Cysteine; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mutation; Radioligand Assay; Receptor, Adenosine A1; Recombinant Fusion Proteins; Sodium Chloride; Sulfur Radioisotopes; Thiophenes; Transfection; Tritium; Xanthines | 2004 |
A "locked-on," constitutively active mutant of the adenosine A1 receptor.
Topics: Adenosine; Animals; Binding, Competitive; Cell Line; Cell Membrane; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Mutation; Plasmids; Radioligand Assay; Receptor, Adenosine A1; Sodium; Sulfur Radioisotopes; Theophylline; Thiophenes; Transfection; Tritium; Xanthines | 2005 |
Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Amino Acid Sequence; Animals; Cell Proliferation; Cells, Cultured; Cloning, Molecular; Coronary Vessels; DNA; Mitogens; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Organ Culture Techniques; Pertussis Toxin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptors, Purinergic P1; RNA, Messenger; Sus scrofa; Thiophenes | 2005 |
Allosteric modulators affect the internalization of human adenosine A1 receptors.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Endocytosis; Humans; Luminescent Proteins; Microscopy, Confocal; Radioligand Assay; Receptor, Adenosine A1; Recombinant Fusion Proteins; Thiadiazoles; Thiazoles; Thiophenes; Transfection; Tritium; Xanthines | 2005 |
The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Allosteric Regulation; Animals; Cell Line; Cyclic AMP; Dogs; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Iodobenzenes; Kidney; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Radioligand Assay; Receptor, Adenosine A1; Receptor, Adenosine A2A; Recombinant Fusion Proteins; Thiophenes; Transfection; Xanthines | 2006 |
Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Allosteric Site; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Molecular; Phosphorylation; Radioligand Assay; Receptor, Adenosine A1; Structure-Activity Relationship; Thiophenes | 2010 |