pd-178390 and sulfamic-acid

pd-178390 has been researched along with sulfamic-acid* in 1 studies

Other Studies

1 other study(ies) available for pd-178390 and sulfamic-acid

Article	Year
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety. Bioorganic & medicinal chemistry letters, 1999, Aug-02, Volume: 9, Issue:15 Dihydropyran-2-ones possessing a sulfamate moiety at the 4-position of the thiophenyl ring were designed to reach S3' pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing 3-(2-t-butyl-5-methyl-4-sulfamate) phenylthio moiety were established. SAR of various sulfamate analogs including HIV protease binding affinities, antiviral activities and therapeutic indices will be described. Topics: Animals; Disulfides; HIV; HIV Protease Inhibitors; Mice; Models, Molecular; Pyrones; Structure-Activity Relationship; Sulfonic Acids	1999

Article

Year

Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety.

Bioorganic & medicinal chemistry letters, 1999, Aug-02, Volume: 9, Issue:15

Dihydropyran-2-ones possessing a sulfamate moiety at the 4-position of the thiophenyl ring were designed to reach S3' pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing 3-(2-t-butyl-5-methyl-4-sulfamate) phenylthio moiety were established. SAR of various sulfamate analogs including HIV protease binding affinities, antiviral activities and therapeutic indices will be described.

Topics: Animals; Disulfides; HIV; HIV Protease Inhibitors; Mice; Models, Molecular; Pyrones; Structure-Activity Relationship; Sulfonic Acids

1999