pd 153035 has been researched along with rtki cpd in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 11 (57.89) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bridges, AJ; Cody, DR; Denny, WA; Fry, DW; Kraker, AJ; McMichael, A; Rewcastle, GW; Showalter, HD; Zhou, H | 1 |
| App, H; Chen, I; Chen, J; Gazit, A; Hirth, P; Levitzki, A; McMahon, G | 1 |
| Bauer, PH; Carlo, AA; Hageman, DL; Mathiowetz, AM; McClure, LD; Treadway, JL; Withka, JM; Wright, SW | 1 |
| Albarran, MI; Bischoff, JR; Corrionero, A; Fominaya, J; Mateos, G; Oyarzabal, J; Palacios, I; Pastor, J; Rabal, O; Reymundo, I; Salgado, A; Urbano-Cuadrado, M; Zarich, N | 1 |
| Baldeyrou, B; Bonte, JP; David-Cordonnier, MH; Depreux, P; Garofalo, A; Goossens, JF; Goossens, L; Lansiaux, A; Lemoine, A; Ravez, S; Six, P | 1 |
| Elmaghrabi, MR; Mubarak, MS; Tayyem, RF; Yousef, AM; Zalloum, HM | 1 |
| Egeblad, M; Jäättelä, M; Mortensen, OH; van Kempen, LC | 1 |
| Belt, A; Fisher, G; Voorhees, J; Wan, Y; Wang, Z | 1 |
| Bode, AM; Chen, N; Dong, Z; Liu, G; Ma, WY; She, QB; Wu, E | 1 |
| Baatar, D; Pai, R; Pavelka, M; Soreghan, B; Szabo, IL; Tarnawski, AS | 1 |
| Bode, AM; Chen, N; Dong, Z; Ma, WY; Zhang, Y | 1 |
| Chatziantoniou, C; Coffman, T; Dussaule, JC; Flamant, M; Henrion, D; Placier, S; Tharaux, PL | 1 |
| Hidaka, K; Morisaki, T; Suk Kim, H | 1 |
| Gaiger, A; Grunt, TW; Kainz, B; Köhler, G; Puckmair, K; Rünzler, D; Tomek, K; Wagner, R; Zielinski, CC | 1 |
| Breza, N; Keri, G; Orfi, L; Petak, I; Pinter, F; Robert, K; Schwab, R; Varkondi, E | 1 |
| Beales, IL; Ogunwobi, OO | 1 |
| Pick, A; Wiese, M | 1 |
| Chang, CM; Chang, WC; Chuang, HY; Hou, MF; Lee, YC; Lin, YC; Tsai, YT; Wang, JY; Wei, PL; Wong, JH | 1 |
| Angelini, M; Benaiteau, F; Fleury, F; Gyulkhandanyan, A; Gyulkhandanyan, L; Le Béchec, M; Lecocq, MF; Logé, C; Reiter, E; Roussakis, C; Rousseau, B; Sakanyan, V | 1 |
19 other study(ies) available for pd 153035 and rtki cpd
| Article | Year |
|---|---|
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
Topics: Aniline Compounds; Binding Sites; Blotting, Western; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Conformation; Molecular Structure; Phosphorylation; Protein Binding; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines.
Topics: Aniline Compounds; ErbB Receptors; Phosphorylation; Protein Kinase C; Quinazolines; Staurosporine; Structure-Activity Relationship | 1996 |
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.
Topics: Allosteric Regulation; Allosteric Site; Aniline Compounds; Animals; Drug Design; Enzyme Inhibitors; Fructose-Bisphosphatase; Humans; Inhibitory Concentration 50; Kidney; Liver; Models, Molecular; Molecular Structure; Quinazolines; Structure-Activity Relationship | 2001 |
Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Databases, Factual; Drug Screening Assays, Antitumor; Humans; Intracellular Signaling Peptides and Proteins; Models, Molecular; Protein Conformation; Protein Serine-Threonine Kinases; Quantitative Structure-Activity Relationship | 2010 |
Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives.
Topics: Aniline Compounds; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Circular Dichroism; DNA; Drug Screening Assays, Antitumor; Fluorescence; Humans; Intercalating Agents; Nucleic Acid Conformation; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Transition Temperature | 2010 |
Ligand-based designing, in silico screening, and biological evaluation of new potent fructose-1,6-bisphosphatase (FBPase) inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Fructose-Bisphosphatase; High-Throughput Screening Assays; Humans; Ligands; Liver; Models, Molecular; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship | 2012 |
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoblotting; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Organic Chemicals; Phosphorylation; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2001 |
Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
Topics: Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-1; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Models, Biological; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinazolines; Time Factors; Tyrphostins | 2001 |
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Ligands; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phenylalanine; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor AP-1; Transcriptional Activation; Tyrphostins | 2001 |
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
Topics: Animals; Cell Line; Colonic Neoplasms; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Gastric Mucosa; Genes, src; Humans; Hypertrophy; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Tyrphostins | 2002 |
Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.
Topics: Animals; Blotting, Western; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Ribosomal Protein S6 Kinases; Signal Transduction; Transfection; Tyrosine; Tyrphostins; Ultraviolet Rays | 2001 |
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Flavonoids; In Vitro Techniques; Luciferases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Quinazolines; Tyrphostins; Vasoconstriction | 2003 |
Expression of ErbB receptors in ES cell-derived cardiomyocytes.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Green Fluorescent Proteins; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Fluorescence; Myocardium; Neuregulin-1; Quinazolines; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tyrphostins; Xenopus Proteins | 2003 |
Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; CpG Islands; DNA Methylation; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Quinazolines; Receptors, Retinoic Acid; RNA Processing, Post-Transcriptional; Transcription, Genetic; Tyrphostins; Up-Regulation | 2007 |
Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.
Topics: Aminoquinolines; Aniline Compounds; Biological Assay; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Inhibitory Concentration 50; Morpholines; Mutant Proteins; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tyrphostins | 2008 |
Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.
Topics: Adenocarcinoma; Amphiregulin; Autoantibodies; Cell Line, Tumor; Cell Proliferation; EGF Family of Proteins; ErbB Receptors; Esophageal Neoplasms; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Leptin; Matrix Metalloproteinases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transforming Growth Factor alpha; Tyrphostins | 2008 |
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins | 2012 |
Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
Topics: Cell Line, Tumor; Environmental Pollutants; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Lead; Proto-Oncogene Proteins c-jun; Quinazolines; Stomach Neoplasms; Transcription Factor AP-1; Tyrphostins; Up-Regulation | 2015 |
Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
Topics: Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Neoplasms; Nitro Compounds; Oxadiazoles; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins | 2014 |