Page last updated: 2024-09-03

pd-117596 and norfloxacin

pd-117596 has been researched along with norfloxacin in 6 studies

Compound Research Comparison

Studies
(pd-117596)
Trials
(pd-117596)
Recent Studies (post-2010)
(pd-117596)
Studies
(norfloxacin)
Trials
(norfloxacin)
Recent Studies (post-2010) (norfloxacin)
21003,077280912

Protein Interaction Comparison

ProteinTaxonomypd-117596 (IC50)norfloxacin (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.02
DNA gyrase subunit AEscherichia coli K-120.6
DNA gyrase subunit BEscherichia coli K-120.6
DNA topoisomerase 4 subunit AStaphylococcus aureus3.5
Cytochrome P450 2C9 Homo sapiens (human)2.56
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.02
Cytochrome P450 2J2Homo sapiens (human)2.56
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.02
GABA theta subunitRattus norvegicus (Norway rat)0.02
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.02

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (83.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cohen, MA; Domagala, JM; Mailloux, GB; Roland, GE; Suto, MJ1
Bridges, AJ; Bucsh, R; Domagala, JM; Gogliotti, RD; Hagen, SE; Heifetz, CL; Joannides, ET; Sanchez, JP; Sesnie, JC; Shapiro, MA1
Bridges, AJ; Culbertson, TP; Domagala, JM; Gambino, L; Hagen, SE; Karrick, G; Porter, K; Sanchez, JP; Sesnie, JA; Spense, FG1
Domagala, JM; Hagen, SE; Heifetz, CL; Johnson, J1
Culbertson, TP; Gambino, L; Sanchez, JP; Sesnie, JA1
García-March, FJ; Jaén-Oltra, J; Pérez-Giménez, F; Salabert-Salvador, MT; Tomás-Vert, F1

Other Studies

6 other study(ies) available for pd-117596 and norfloxacin

ArticleYear
Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity.
    Journal of medicinal chemistry, 1992, Dec-11, Volume: 35, Issue:25

    Topics: Animals; Anti-Infective Agents; Cricetinae; Cricetulus; Fluoroquinolones; Microbial Sensitivity Tests; Structure-Activity Relationship

1992
New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.
    Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2

    Topics: 4-Quinolones; Administration, Oral; Animals; Anti-Infective Agents; Bacterial Infections; Female; Injections, Subcutaneous; Mice; Microbial Sensitivity Tests; Photosensitivity Disorders; Structure-Activity Relationship

1992
Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: Alkylation; Aminoquinolines; Animals; Anti-Bacterial Agents; Bacterial Infections; Chemical Phenomena; Chemistry; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydroxyquinolines; Mice; Microbial Sensitivity Tests; Molecular Structure; Piperazines; Pyrrolidines; Structure-Activity Relationship; Topoisomerase II Inhibitors

1991
Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: 4-Quinolones; Anti-Infective Agents; Chemical Phenomena; Chemistry; Gram-Negative Bacteria; Gram-Positive Bacteria; Methylation; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship

1991
Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Bacteria; Chemical Phenomena; Chemistry; Gram-Negative Bacteria; Gram-Positive Bacteria; Molecular Structure; Piperazines; Pyrrolidines; Quinolines; Spiro Compounds; Structure-Activity Relationship

1990
Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods.
    Journal of medicinal chemistry, 2000, Mar-23, Volume: 43, Issue:6

    Topics: Algorithms; Anti-Infective Agents; Fluoroquinolones; Microbial Sensitivity Tests; Neural Networks, Computer; Structure-Activity Relationship

2000