pd-117596 has been researched along with ciprofloxacin in 14 studies
| Studies (pd-117596) | Trials (pd-117596) | Recent Studies (post-2010) (pd-117596) | Studies (ciprofloxacin) | Trials (ciprofloxacin) | Recent Studies (post-2010) (ciprofloxacin) |
|---|---|---|---|---|---|
| 21 | 0 | 0 | 16,060 | 1,331 | 6,092 |
| Protein | Taxonomy | pd-117596 (IC50) | ciprofloxacin (IC50) |
|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | 0.41 | |
| DNA gyrase subunit B | Bacillus subtilis subsp. subtilis str. 168 | 6.3 | |
| DNA gyrase subunit A | Bacillus subtilis subsp. subtilis str. 168 | 6.3 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.31 | |
| DNA gyrase subunit B | Staphylococcus aureus | 4.32 | |
| DNA gyrase subunit A | Escherichia coli K-12 | 0.6845 | |
| DNA gyrase subunit B | Escherichia coli K-12 | 0.5632 | |
| DNA topoisomerase 4 subunit B | Staphylococcus aureus | 6.485 | |
| DNA topoisomerase 4 subunit A | Staphylococcus aureus | 4.8011 | |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | 0.41 | |
| DNA gyrase subunit A | Staphylococcus aureus | 4.32 | |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.41 | |
| DNA topoisomerase 4 subunit A | Bacillus subtilis subsp. subtilis str. 168 | 1.7 | |
| DNA topoisomerase 4 subunit B | Bacillus subtilis subsp. subtilis str. 168 | 1.7 | |
| GABA theta subunit | Rattus norvegicus (Norway rat) | 0.41 | |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | 0.41 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (92.86) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cohen, MA; Domagala, JM; Mailloux, GB; Roland, GE; Suto, MJ | 1 |
| Bouzard, D; Coroneos, E; Ledoussal, B | 1 |
| Bridges, AJ; Bucsh, R; Domagala, JM; Gogliotti, RD; Hagen, SE; Heifetz, CL; Joannides, ET; Sanchez, JP; Sesnie, JC; Shapiro, MA | 1 |
| Bridges, AJ; Culbertson, TP; Domagala, JM; Gambino, L; Hagen, SE; Karrick, G; Porter, K; Sanchez, JP; Sesnie, JA; Spense, FG | 1 |
| Domagala, JM; Hagen, SE; Heifetz, CL; Johnson, J | 1 |
| Culbertson, TP; Gambino, L; Sanchez, JP; Sesnie, JA | 1 |
| Cohen, MA; Domagala, JM; Gogliotti, RD; Gracheck, SJ; Huband, MD; Sanchez, JP; Sesnie, JA; Shapiro, MA | 1 |
| Domagala, JM; Gracheck, SJ; Hagen, SE; Sesnie, JA; Stier, MA; Suto, MJ | 1 |
| Domagala, JM; Hagen, SE; Joannides, T; Kiely, JS; Laborde, E; Schroeder, MC; Sesnie, JA; Shapiro, MA; Suto, MJ; Vanderroest, S | 1 |
| García-March, FJ; Jaén-Oltra, J; Pérez-Giménez, F; Salabert-Salvador, MT; Tomás-Vert, F | 1 |
| Bailey, DL; Epling, GA; Kiely, JS; Robertson, DG; Song, B | 1 |
| Hall, MC; Piddock, LJ; Walters, RN | 1 |
| Bodey, GP; Ho, DH; LeBlanc, B; Rolston, KV | 1 |
| Amyes, SG; Barnes, AC; Hastings, TS; Lewin, CS | 1 |
14 other study(ies) available for pd-117596 and ciprofloxacin
| Article | Year |
|---|---|
Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity.
Topics: Animals; Anti-Infective Agents; Cricetinae; Cricetulus; Fluoroquinolones; Microbial Sensitivity Tests; Structure-Activity Relationship | 1992 |
Potent non-6-fluoro-substituted quinolone antibacterials: synthesis and biological activity.
Topics: 4-Quinolones; Anti-Infective Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydrocarbons, Fluorinated; Microbial Sensitivity Tests; Structure-Activity Relationship | 1992 |
New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.
Topics: 4-Quinolones; Administration, Oral; Animals; Anti-Infective Agents; Bacterial Infections; Female; Injections, Subcutaneous; Mice; Microbial Sensitivity Tests; Photosensitivity Disorders; Structure-Activity Relationship | 1992 |
Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.
Topics: Alkylation; Aminoquinolines; Animals; Anti-Bacterial Agents; Bacterial Infections; Chemical Phenomena; Chemistry; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydroxyquinolines; Mice; Microbial Sensitivity Tests; Molecular Structure; Piperazines; Pyrrolidines; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1991 |
Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids.
Topics: 4-Quinolones; Anti-Infective Agents; Chemical Phenomena; Chemistry; Gram-Negative Bacteria; Gram-Positive Bacteria; Methylation; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship | 1991 |
Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships.
Topics: Bacteria; Chemical Phenomena; Chemistry; Gram-Negative Bacteria; Gram-Positive Bacteria; Molecular Structure; Piperazines; Pyrrolidines; Quinolines; Spiro Compounds; Structure-Activity Relationship | 1990 |
The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents.
Topics: Animals; Anti-Bacterial Agents; Bacteria; CHO Cells; Cricetinae; Dermatitis, Phototoxic; Drug Design; Female; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Quinolones; Structure-Activity Relationship | 1995 |
Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential.
Topics: 4-Quinolones; Administration, Oral; Animals; Anti-Infective Agents; Cricetinae; Cricetulus; Female; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Microbial Sensitivity Tests; Naphthyridines; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship | 1994 |
Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Cricetinae; Cricetulus; Female; Fluoroquinolones; Mice; Microbial Sensitivity Tests; Naphthyridines; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1993 |
Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods.
Topics: Algorithms; Anti-Infective Agents; Fluoroquinolones; Microbial Sensitivity Tests; Neural Networks, Computer; Structure-Activity Relationship | 2000 |
Mechanistic studies of the phototoxic potential of PD 117596, a quinolone antibacterial compound.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Antioxidants; Ciprofloxacin; Dose-Response Relationship, Drug; Fluoroquinolones; Free Radical Scavengers; Hemolysis; Male; Mice; Mice, Inbred Strains; Nalidixic Acid; Nitroso Compounds; Oxygen; Photochemistry; Photolysis; Quinolones; Thiobarbiturates | 1991 |
Phenotypic characterization of quinolone-resistant mutants of Enterobacteriaceae selected from wild type, gyrA type and multiply-resistant (marA) type strains.
Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Enterobacter cloacae; Enterobacteriaceae; Escherichia coli; Fluoroquinolones; Klebsiella pneumoniae; Mutation; Nalidixic Acid; Phenotype; Quinolones; Serratia marcescens; Species Specificity | 1991 |
In-vitro activity of PD 117 596, a new quinolone, against bacterial isolates from cancer patients.
Topics: Anti-Infective Agents; Bacteria; Bacterial Infections; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Neoplasms; Quinolones | 1990 |
In vitro activities of 4-quinolones against the fish pathogen Aeromonas salmonicida.
Topics: Aeromonas; Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enrofloxacin; Fluoroquinolones; Microbial Sensitivity Tests; Osmolar Concentration; Oxolinic Acid; Quinolones; Sodium Chloride | 1990 |