Page last updated: 2024-09-03

pd 117302 and thiophenes

pd 117302 has been researched along with thiophenes in 46 studies

Compound Research Comparison

Studies (pd 117302)	Trials (pd 117302)	Recent Studies (post-2010) (pd 117302)	Studies (thiophenes)	Trials (thiophenes)	Recent Studies (post-2010) (thiophenes)
48	0	2	17,012	1,961	8,038

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (19.57)	18.7374
1990's	31 (67.39)	18.2507
2000's	4 (8.70)	29.6817
2010's	2 (4.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Clifton, PG; Lee, MD	1
Bansinath, M; Puig, MM; Ramabadran, K; Turndorf, H	1
Cowan, A; Wheeler-Aceto, H	2
Bansinath, M; Ramabadran, K; Shukla, VK; Turndorf, H	1
Bianchi, G; Colombo, M; La Regina, A; Petrillo, P; Tavani, A	1
Baldwin, BA; Ebenezer, IS; Forsling, ML; Parrott, RF	1
Echevarria, E; Hughes, J; Hunter, JC; Robles, L; Tortella, FC	1
Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC	1
Cowan, A; Ianone, M; Porreca, F; Wheeler, H	1
Bianchi, G	1
Alvinerie, M; Buéno, L; Gué, M; Junien, JL	1
Boyle, SJ; Hughes, J; Hunter, JC; Meecham, KG	1
Hill, RG; Hughes, J; Johnson, MA; Leighton, GE; Meecham, KG	1
Hewson, G; Hill, RG; Hughes, J; Leighton, GE; Turner, WD	1
Birchmore, B; Clark, CR; Hill, RG; Hughes, J; Hunter, JC; Sharif, NA	1
Hill, RG; Hughes, J; Leighton, GE	2
Hayes, ES; Pugsley, MK; Saint, DA; Walker, MJ	1
Blanchard, JC; Carruette, A; Garret, C; Laduron, PM; Montier, F; Moussaoui, SM	1
Carruette, A; Garret, C; Moussaoui, S	1
Diop, L; Junien, JL; Langlois, A; Pascaud, X; Rivière, PJ	1
Coenen, A; Lasoń, W; Machelska, H; Przewłocka, B; Przewłocki, R; van Luijtelaar, G	1
Bansinath, M; Shukla, VK; Turndorf, H	1
Nagasaka, H; Yaksh, TL	1
Lasoń, W; Machelska, H; Przewłocka, B	1
Besley, W; Gray, G; Nolan, AM; Reid, J	1
Genovese, RF; Moreton, JE; Tortella, FC	1
Headley, PM; Herrero, JF	1
de Costa, BR; Haaseth, RC; Horan, PJ; Hruby, VJ; Porreca, F; Rice, K	1
Magyar, A; Medzihradszky, K; Rónai, AZ	1
Grouhel, A; Wettstein, JG	1
Walker, MJ; Walker, ML; Wall, RA	1
Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ	1
Hughes, J; Hunter, JC; Moreton, JE; Robles, L; Rose, J; Tortella, FC	1
DeCoster, MA; Tortella, FC	1
Antoon, JS; Perry, MA; Walker, JS; Wilson, JL	1
Goldin, AL; Pugsley, MK	2
Holtzman, SG; Powell, KR	1
Sheridan, RD	1
Bergman, J; Carey, GJ	1
Corso, G; de Nucci, G; Eberlin, MN; Ifa, DR; Moraes, LA; Ribeiro, W; Salmon, J	1
Gullapalli, S; Ramarao, P	1
Abraham, S; Hayes, ES; Pugsley, MK; Saint, DA; Walker, MJ	1
Abraham, S; Adaikan, G; Beatch, GN; Goldin, AL; Hayes, ES; MacLeod, BA; Pugsley, MK; Saint, DA; Walker, MJA; Wall, RA	1

Reviews

1 review(s) available for pd 117302 and thiophenes

Article	Year
Kappa opioids: therapeutic considerations in epilepsy and CNS injury. Clinical neuropharmacology, 1994, Volume: 17, Issue:5 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Benzofurans; Central Nervous System Diseases; Epilepsy; Humans; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Thiophenes	1994

Other Studies

45 other study(ies) available for pd 117302 and thiophenes

Article	Year
Free-feeding and free-drinking patterns of male rats following treatment with opiate kappa agonists. Physiology & behavior, 1992, Volume: 52, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Male; Pyrroles; Pyrrolidines; Rats; Receptors, Opioid, kappa; Thiophenes	1992
Kappa-opiate agonist-induced inhibition of gastrointestinal transit in different strains of mice. Pharmacology, 1991, Volume: 42, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Gastrointestinal Transit; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Species Specificity; Thiophenes	1991
Involvement of a peripheral component in the antinociceptive effects of opioids in a model of tonic pain. NIDA research monograph, 1990, Volume: 105 Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Morphine; Narcotics; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1990
Intracerebroventricular administration of kappa-agonists induces convulsions in mice. Brain research bulletin, 1991, Volume: 27, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Baclofen; Benzeneacetamides; Benzomorphans; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Injections, Intraventricular; Ketamine; Mice; Mice, Inbred Strains; Muscimol; Naloxone; Narcotic Antagonists; Narcotics; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Seizures; Stereoisomerism; Thiophenes	1991
In vitro binding profile and in vivo pharmacological properties of the K-opioid compound PD 117302. Research communications in chemical pathology and pharmacology, 1991, Volume: 72, Issue:3 Topics: Analgesia; Animals; Binding Sites; Brain; Culture Techniques; Diprenorphine; Diuresis; Dose-Response Relationship, Drug; Gastrointestinal Transit; Injections, Intravenous; Male; Naloxone; Pain Measurement; Pyrroles; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1991
Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology, 1991, Volume: 104, Issue:1 Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Decerebrate State; Foot; Formaldehyde; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reference Standards; Thiophenes	1991
Hormonal effects of apomorphine and cholecystokinin in pigs: modification of the response to cholecystokinin by a dopamine antagonist (metoclopramide) and a kappa opioid agonist (PD117302). Acta endocrinologica, 1991, Volume: 125, Issue:4 Topics: Animals; Apomorphine; Cholecystokinin; Dopamine Antagonists; Feeding Behavior; Female; Hydrocortisone; Lypressin; Male; Metoclopramide; Pyrroles; Swine; Thiophenes	1991
PD117302, a selective non-peptide opioid kappa agonist, protects against NMDA and maximal electroshock convulsions in rats. Life sciences, 1990, Volume: 46, Issue:17 Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Electroshock; Flurothyl; Male; N-Methylaspartate; Pyrroles; Random Allocation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes; Time Factors	1990
Characterization of kappa-opioid receptors in the guinea-pig ileum. European journal of pharmacology, 1990, Jun-21, Volume: 182, Issue:1 Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1990
Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats. Proceedings of the Western Pharmacology Society, 1989, Volume: 32 Topics: Animals; Colon; Dose-Response Relationship, Drug; Formaldehyde; Gastrointestinal Transit; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1989
High-performance liquid chromatographic assay of k-opioid selective benzeneacetamide derivatives (U50488, U69593 and PD117302) in rat plasma and brain. Journal of chromatography, 1989, Jul-21, Volume: 491, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Brain Chemistry; Chromatography, High Pressure Liquid; Male; Pyrroles; Pyrrolidines; Rats; Receptors, Opioid; Thiophenes	1989
Stimulation of kappa opiate receptors in intestinal wall affects stress-induced increase of plasma cortisol in dogs. Brain research, 1989, Nov-13, Volume: 502, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Administration, Oral; Animals; Corticotropin-Releasing Hormone; Dogs; Hydrocortisone; Injections, Intraventricular; Intestines; Male; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Thiophenes	1989
An in vitro profile of activity for the (+) and (-) enantiomers of spiradoline and PD117302. European journal of pharmacology, 1989, Dec-07, Volume: 173, Issue:2-3 Topics: Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Pyrroles; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Thiophenes; Vas Deferens	1989
Pharmacological profile of PD 117302, a selective kappa-opioid agonist. British journal of pharmacology, 1987, Volume: 92, Issue:4 Topics: Analgesics; Animals; Depression, Chemical; Diuretics; Gastrointestinal Motility; Injections, Intravenous; Male; Mice; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Respiration; Substance-Related Disorders; Thiophenes	1987
The kappa agonists PD117302 and U50488 produce a biphasic effect on 24 hour food intake in the rat. Neuropharmacology, 1987, Volume: 26, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Eating; Male; Narcotics; Pyrroles; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1987
PD117302: a selective agonist for the kappa-opioid receptor. British journal of pharmacology, 1988, Volume: 93, Issue:3 Topics: Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Pyrroles; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes; Vas Deferens	1988
The effects of the kappa agonist PD-117302 on feeding behaviour in obese and lean Zucker rats. Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:2 Topics: Animals; Eating; Feeding Behavior; Hyperphagia; Male; Obesity; Pyrroles; Rats; Rats, Zucker; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1988
Effects of 5-HT and alpha 1 adrenoceptor antagonists on kappa opioid-induced sedation. Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Brain Chemistry; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Motor Activity; Prazosin; Pyrroles; Pyrrolidines; Receptors, Opioid; Serotonin; Serotonin Antagonists; Thiophenes	1988
Do related kappa agonists produce similar effects on cardiac ion channels? Proceedings of the Western Pharmacology Society, 1995, Volume: 38 Topics: Animals; Anti-Arrhythmia Agents; Benzofurans; Blood Pressure; Electric Stimulation; Electrocardiography; Heart; Heart Rate; Heart Ventricles; Ion Channels; Male; Myocardium; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereoisomerism; Thiophenes	1995
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically. British journal of pharmacology, 1993, Volume: 109, Issue:1 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Capsaicin; Electric Stimulation; Indoles; Inflammation; Injections, Intravenous; Isoindoles; Male; Morphine; Mucus; Nasal Mucosa; Pyrroles; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Synapses; Thiophenes; Xylenes	1993
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists. Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2 Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes	1993
Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat. European journal of pharmacology, 1994, Dec-27, Volume: 271, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Acetic Acid; Amino Acid Sequence; Anesthesia; Animals; Benzyl Compounds; Blood Pressure; Colon; Dose-Response Relationship, Drug; Male; Molecular Sequence Data; Pain; Propylamines; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reflex; Thiophenes	1994
Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats. Neuroscience letters, 1995, Feb-17, Volume: 186, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Absence; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Naltrexone; Pyrroles; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1995
Pertussis and cholera toxins modulate kappa-opioid receptor agonists-induced hypothermia and gut inhibition. European journal of pharmacology, 1995, Mar-16, Volume: 292, Issue:3-4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Body Temperature; Cholera Toxin; Digestive System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Injections, Intraventricular; Male; Mice; Pertussis Toxin; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Thiophenes; Virulence Factors, Bordetella	1995
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats. Anesthesia and analgesia, 1995, Volume: 80, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes	1995
Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1994, Volume: 4, Issue:4 Topics: Analgesics; Animals; Benzeneacetamides; Brain; Injections, Intraperitoneal; Mice; Naltrexone; Pilocarpine; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Seizures; Thiophenes	1994
The effects of butorphanol on locomotor activity in ponies: a preliminary study. Journal of veterinary pharmacology and therapeutics, 1994, Volume: 17, Issue:4 Topics: Animals; Butorphanol; Drug Combinations; Female; Horses; Male; Motor Activity; Naloxone; Pyrroles; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1994
Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia. Brain research bulletin, 1994, Volume: 34, Issue:2 Topics: Animals; Cell Death; Conditioning, Operant; Ischemic Attack, Transient; Male; Prosencephalon; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement Schedule; Thiophenes	1994
Functional evidence for multiple receptor activation by kappa-ligands in the inhibition of spinal nociceptive reflexes in the rat. British journal of pharmacology, 1993, Volume: 110, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Benzofurans; Blood Pressure; Decerebrate State; Male; Naloxone; Nociceptors; Piperazines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord; Thiophenes	1993
Differential antagonism of bremazocine- and U69,593-induced antinociception by quadazocine: further functional evidence of opioid kappa receptor multiplicity in the mouse. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2 Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzodiazepines; Benzomorphans; Cyclohexanes; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship; Thiophenes	1993
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens. Neuropeptides, 1993, Volume: 25, Issue:2 Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens	1993
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay. Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1996
Determination of an arylacetamide antiarrhythmic in rat blood and tissues using reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications, 1996, Jan-26, Volume: 675, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Pyrroles; Rats; Reproducibility of Results; Spectrophotometry, Ultraviolet; Thiophenes	1996
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats. Life sciences, 1997, Volume: 60, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1997
EEG spectral analysis of the neuroprotective kappa opioids enadoline and PD117302. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: Animals; Benzofurans; Electroencephalography; Male; Narcotics; Neuroprotective Agents; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Thiophenes	1997
Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: inhibition by kappa-opioid agonist but not by NSAID. The Journal of rheumatology, 1998, Volume: 25, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Female; Intercellular Adhesion Molecule-1; Naproxen; Narcotics; Pyrroles; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Thiophenes	1998
Time- and voltage-dependent block of sodium channels expressed in Xenopus oocytes by RSD 921, a novel class I antiarrhythmic drug. Proceedings of the Western Pharmacology Society, 1998, Volume: 41 Topics: Animals; Anti-Arrhythmia Agents; Brain; Dose-Response Relationship, Drug; Electric Conductivity; Heart; In Vitro Techniques; Neurons; Pyrroles; Rats; Sodium Channel Blockers; Thiophenes; Time Factors; Xenopus laevis	1998
Molecular analysis of the Na+ channel blocking actions of the novel class I anti-arrhythmic agent RSD 921. British journal of pharmacology, 1999, Volume: 127, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Electric Stimulation; In Vitro Techniques; Ion Channel Gating; Muscle, Skeletal; Mutation; Myocardium; Neurons; Oocytes; Patch-Clamp Techniques; Pyrroles; Rats; RNA; Sodium Channel Blockers; Sodium Channels; Thiophenes; Transcription, Genetic; Xenopus laevis	1999
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine. European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes	1999
Quantification of state-dependent drug interactions with the sodium channel. British journal of pharmacology, 2000, Volume: 129, Issue:2 Topics: Anti-Arrhythmia Agents; Humans; Pyrroles; Sodium Channels; Thiophenes	2000
Enadoline discrimination in squirrel monkeys: effects of opioid agonists and antagonists. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Animals; Benzofurans; Discrimination Learning; Dose-Response Relationship, Drug; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Thiophenes	2001
Determination of RSD921 in human plasma by high-performance liquid chromatography-tandem mass spectrometry using tri-deuterated RSD921 as internal standard: application to a phase I clinical trial. Journal of mass spectrometry : JMS, 2001, Volume: 36, Issue:10 Topics: Anesthetics, Local; Anti-Arrhythmia Agents; Calibration; Chromatography, High Pressure Liquid; Clinical Trials, Phase I as Topic; Deuterium; Humans; Indicators and Reagents; Mass Spectrometry; Pyrroles; Quality Control; Reference Standards; Thiophenes	2001
L-type Ca2+ channel modulation by dihydropyridines potentiates kappa-opioid receptor agonist induced acute analgesia and inhibits development of tolerance in rats. Neuropharmacology, 2002, Volume: 42, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Benzeneacetamides; Calcium Channels, L-Type; Cannabinoids; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Male; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Thiophenes	2002
An examination of the cardiac actions of PD117,302, a κ-opioid receptor agonist. European journal of pharmacology, 2015, Aug-15, Volume: 761 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Binding, Competitive; Cardiac Pacing, Artificial; Cerebellum; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart Conduction System; Heart Rate; Heart Ventricles; Isolated Heart Preparation; Ligands; Male; Mice, Inbred BALB C; Myocardial Contraction; Pain; Pain Threshold; Potassium Channel Blockers; Potassium Channels; Protein Binding; Pyrroles; Radioligand Assay; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium Channel Blockers; Sodium Channels; Thiophenes; Ventricular Function, Left; Ventricular Pressure	2015
Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106 Topics: Action Potentials; Administration, Intravenous; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Humans; Injections, Intradermal; Isolated Heart Preparation; Male; Mice; Myocytes, Cardiac; Neural Conduction; Pain Threshold; Papio; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Thiophenes; Time Factors; Xenopus laevis	2018