Compounds > pca 4248

pca 4248 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

pca 4248 has been researched along with 1-hexadecyl-2-acetyl-glycero-3-phosphocholine in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (66.67)18.2507
2000's3 (14.29)29.6817
2010's4 (19.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Lima, MC; Martins, MA; Silva, AR; Silva, PM; Vargaftig, BB1
Achiwa, K; Ebiike, H; Maruyama, K1
Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Correia-Da-Silva, AC; Martins, MA; Morhy, L; Sousa, MV1
de Casa-Juana, MF; García, MC; Gijón, MA; Ortega, MP; Priego, JG; Sanchez Crespo, M; Sunkel, C1
de Casa-Juana, MF; Fernández-Gallardo, S; Ortega, MP; Priego, JG; Sánchez Crespo, M; Sunkel, C1
de Casa-Juana, MF; Gómez, MM; González-Morales, MA; Ortega, MP; Priego, JG; Santos, L; Sunkel, CE; Villarroya, M1
Aragonés, MD; Catalán, RE; Garde, E; Lombardía, M; Martínez, AM1
Desquand, S; Hatmi, M; Lefort, J; Pina, M; Priego, JG; Ruffié, C; Vargaftig, BB1
Aragonés, MD; Calcerrada, MC; Catalán, RE; Fernández, I; Martínez, AM; Miguel, BG; Pérez, MJ1
Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Larangeira, AP; Martins, MA; Silva, AR; Silva, PM1
Amorim, CZ; Cordeiro, RS; Vargaftig, BB1
Bozza, PT; Cordeiro, RS; Faria Neto, HC; Lima, MC; Martins, MA; Silva, PM; Sunkel, CE1
Calcerrada, MC; Catalán, RE; Hernández, F; Martínez, AM; Pérez, MJ1
Ferreira, MG; Fonteles, MC1
Bolsover, S; Ranasinghe, S1
Byrne, SN; Matsumura, Y; Miyahara, Y; Nghiem, DX; Ullrich, SE1
Bar-Eli, M; Melnikova, V1
Cassali, GD; Fagundes, CT; Garcia, CC; Guabiraba, R; Machado, AV; Polidoro, RB; Russo, RC; Salgado, AP; Sousa, LP; Tavares, LP; Teixeira, MM1
Bambach, I; Huettner, B; Koefeler, H; Mayer, G; Schön, MP; Singh, TP; Wallbrecht, K; Wolf, P1
Cunha, FQ; Cunha, TM; Ferreira, SH; Guerrero, AT; Pinto, LG; Verri, WA; Vieira, SM; Zaperlon, AC; Zarpelon, AC1
Borges, AF; de Oliveira, MAP; Dorta, ML; Gomes, RS; Morato, CI; Ribeiro-Dias, F1

Reviews

1 review(s) available for pca 4248 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

ArticleYear
Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor.
    Cancer metastasis reviews, 2007, Volume: 26, Issue:3-4

    Topics: Animals; Cyclic AMP Response Element-Binding Protein; Dihydropyridines; Humans; Inflammation; Lung Neoplasms; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Melanoma; Neovascularization, Pathologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteins; Receptors, G-Protein-Coupled; Signal Transduction

2007

Other Studies

20 other study(ies) available for pca 4248 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

ArticleYear
Interference of azelastine with anaphylaxis induced by ovalbumin challenge in actively sensitized rats.
    European journal of pharmacology, 1992, Mar-24, Volume: 213, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Dihydropyridines; Dose-Response Relationship, Drug; Hematocrit; Histamine H1 Antagonists; Leukocyte Count; Male; Meclizine; Ovalbumin; Phthalazines; Platelet Activating Factor; Platelet Count; Rats; Rats, Inbred Strains; Terfenadine; Triazoles

1992
Lipase-catalyzed enantioselective hydrolysis of 4-alkyl-1,4-dihydropyridine derivatives: synthesis of (+)- and (-)-methyl 2-(phenylthio)ethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (PCA 4248).
    Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:4

    Topics: Dihydropyridines; Hydrolysis; Lipase; Platelet Activating Factor; Stereoisomerism

1992
Enterolobin induces rat paw oedema independently of PAF-acether.
    Memorias do Instituto Oswaldo Cruz, 1991, Volume: 86 Suppl 2

    Topics: Animals; Azepines; Dihydropyridines; Diterpenes; Edema; Ginkgolides; Lactones; Male; Plant Proteins; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles

1991
1,4-Dihydropyridines, a new class of platelet-activating factor receptor antagonists: in vitro pharmacologic studies.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:1

    Topics: Animals; Blood Platelets; Dihydropyridines; Humans; In Vitro Techniques; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin

1990
Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:1

    Topics: Animals; Blood Pressure; Capillary Permeability; Dihydropyridines; Endotoxins; Male; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha

1990
4-Alkyl-1,4-dihydropyridines derivatives as specific PAF-acether antagonists.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:12

    Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Blood Platelets; Blood Pressure; Chemical Phenomena; Chemistry; Dihydropyridines; Heart Rate; Ileum; Male; Microsomes; Molecular Structure; Muscle Contraction; Myocardial Contraction; Nitrendipine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled

1990
PCA-4248, a PAF receptor antagonist, inhibits PAF-induced phosphoinositide turnover.
    European journal of pharmacology, 1995, Aug-15, Volume: 290, Issue:3

    Topics: Animals; Blood Platelets; Cell Membrane; Dihydropyridines; In Vitro Techniques; Kinetics; Phosphatidylinositols; Phosphorus Radioisotopes; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin

1995
Compound PCA-4248 interferes with bronchopulmonary anaphylaxis and with in vitro hyperresponsiveness to platelet-activating factor.
    European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1

    Topics: Anaphylaxis; Animals; Blood Cell Count; Bronchial Hyperreactivity; Bronchoconstriction; Dihydropyridines; Female; Guinea Pigs; Histamine Release; Immunization; In Vitro Techniques; Injections, Intravenous; Lung; Male; Platelet Activating Factor; Radioimmunoassay; Thromboxane B2

1993
Platelet-activating factor inhibits (Na+,K+) ATPase activity in rat brain.
    Neuroscience research, 1994, Volume: 19, Issue:2

    Topics: Animals; Brain; Calcium; Dihydropyridines; Egtazic Acid; In Vitro Techniques; Male; Platelet Activating Factor; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase

1994
Lipopolysaccharide-induced pleural neutrophil accumulation depends on marrow neutrophils and platelet-activating factor.
    European journal of pharmacology, 1994, Apr-04, Volume: 270, Issue:2-3

    Topics: Animals; Azepines; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cell Movement; Dihydropyridines; Escherichia coli; Injections; Kinetics; Leukocyte Count; Lipopolysaccharides; Male; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pleura; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thorax; Triazoles

1994
Interference of PCA 4248, a novel PAF receptor antagonist, with antigen-induced paw edema in mice.
    European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2

    Topics: Animals; Dihydropyridines; Edema; Injections, Intraperitoneal; Male; Mice; Ovalbumin; Platelet Activating Factor

1993
Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen.
    European journal of pharmacology, 1993, Jun-11, Volume: 237, Issue:1

    Topics: Allergens; Animals; Bradykinin; Dihydropyridines; Edema; Eosinophils; Exudates and Transudates; Female; Histamine; Hypersensitivity; Leukocyte Count; Male; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pleurisy; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin

1993
Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices.
    Biochemical and biophysical research communications, 1996, Sep-04, Volume: 226, Issue:1

    Topics: Animals; Arginine; Cyclic GMP; Dihydropyridines; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Platelet Activating Factor; Rats; Rats, Wistar

1996
Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney.
    Research communications in molecular pathology and pharmacology, 1996, Volume: 94, Issue:2

    Topics: Animals; Azepines; Dihydropyridines; Ginkgolides; In Vitro Techniques; Kidney; Lactones; Norepinephrine; Platelet Activating Factor; Rabbits; Tachyphylaxis; Triazoles; Vasoconstriction

1996
Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 95, Issue:2

    Topics: Aniline Compounds; Calcium; Calcium Signaling; Cell Line; Dihydropyridines; Diterpenes; Ginkgolides; Glyceryl Ethers; Humans; Lactones; Microglia; Platelet Activating Factor; United Kingdom; Xanthenes

2004
A role for inflammatory mediators in the induction of immunoregulatory B cells.
    Journal of immunology (Baltimore, Md. : 1950), 2006, Oct-01, Volume: 177, Issue:7

    Topics: Adoptive Transfer; Animals; Antigens, CD19; B-Lymphocytes; Dermatitis, Contact; Dihydropyridines; Flow Cytometry; Fluorescein-5-isothiocyanate; Immune Tolerance; Inflammation; Interleukin-10; Leukocyte Common Antigens; Lymphocyte Activation; Mice; Mice, Mutant Strains; Platelet Activating Factor; Serotonin; Serotonin Antagonists; Ultraviolet Rays

2006
Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice.
    PLoS pathogens, 2010, Nov-04, Volume: 6, Issue:11

    Topics: Animals; Apoptosis; Blotting, Western; Chickens; Dihydropyridines; Disease Models, Animal; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orthomyxoviridae Infections; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Toll-Like Receptors; Viral Load

2010
Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice.
    The American journal of pathology, 2011, Volume: 178, Issue:2

    Topics: Animals; Cytokines; Dihydropyridines; Disease Progression; Down-Regulation; Humans; Mice; Mice, Transgenic; Phenotype; Platelet Activating Factor; Platelet Membrane Glycoproteins; Psoriasis; PUVA Therapy; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Skin; STAT3 Transcription Factor; Th17 Cells; Transforming Growth Factor beta1; Up-Regulation

2011
The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:1

    Topics: Animals; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Immune System Diseases; Inflammation; Joint Diseases; Leukocyte Disorders; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandins; Receptors, G-Protein-Coupled; Time Factors; Zymosan

2013
Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis.
    Pathogens and disease, 2017, 09-29, Volume: 75, Issue:7

    Topics: Acetophenones; Dihydropyridines; Enzyme Inhibitors; Gene Expression; Humans; Leishmania braziliensis; Macrophages; NADPH Oxidases; Phagocytosis; Platelet Activating Factor; Primary Cell Culture; Reactive Oxygen Species; Respiratory Burst

2017