pc190723 and 2-6-difluorobenzamide

pc190723 has been researched along with 2-6-difluorobenzamide* in 1 studies

Other Studies

1 other study(ies) available for pc190723 and 2-6-difluorobenzamide

Article	Year
Benzodioxane-benzamides as new bacterial cell division inhibitors. European journal of medicinal chemistry, 2015, Jan-07, Volume: 89 A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds. Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzamides; Cell Division; Cell Survival; Chlorocebus aethiops; Cytoskeletal Proteins; Dioxanes; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Pyridines; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Vero Cells	2015

Article

Year

Benzodioxane-benzamides as new bacterial cell division inhibitors.

European journal of medicinal chemistry, 2015, Jan-07, Volume: 89

A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds.

Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzamides; Cell Division; Cell Survival; Chlorocebus aethiops; Cytoskeletal Proteins; Dioxanes; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Pyridines; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Vero Cells

2015