paxilline has been researched along with tyrosine in 310 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 120 (38.71) | 18.2507 |
| 2000's | 151 (48.71) | 29.6817 |
| 2010's | 35 (11.29) | 24.3611 |
| 2020's | 4 (1.29) | 2.80 |
| Authors | Studies |
|---|---|
| Burridge, K; Romer, LH; Turner, CE | 1 |
| Turner, CE | 2 |
| Chen, LB; de Jong, R; Druker, B; Heisterkamp, N; Li, JL; Okuda, K; Pisick, E; Salgia, R; Sattler, M; Uemura, N | 1 |
| Chang, P; Greenberg, S; Silverstein, SC | 1 |
| Birge, RB; Fajardo, JE; Glassman, R; Hanafusa, H; Hempstead, BL; Kraemer, R; Mahadeo, D | 1 |
| Rozengurt, E; Seufferlein, T | 2 |
| Hanafusa, H; Hata, A; Nakagawa, H; Okada, M; Sabe, H | 1 |
| Morii, N; Narumiya, S; Rankin, S; Rozengurt, E | 1 |
| Anderson, DC; Brown, EJ; Graham, IL; Holers, VM | 1 |
| Fuortes, M; Jin, WW; Nathan, C | 1 |
| Miller, JT; Turner, CE | 1 |
| Charonis, AS; Hasegawa, G; Hunter, AJ | 1 |
| Adam, LP; Gunst, SJ; Pavalko, FM; Walker, TL; Wu, MF | 1 |
| Hall, A; Nobes, CD | 1 |
| Khan, MA; Kobayashi, S; Nakagawa, H; Okada, M; Okumura, N | 1 |
| Molloy, CJ; Pietras, KM; Taylor, DS; Turner, CE | 1 |
| Parsons, JT; Schaller, MD | 1 |
| Abedi, H; Dawes, KE; Zachary, I | 1 |
| Corvaia, N; Coutant, KD; Ryder, NS | 1 |
| Bhattacharya, J; Bhattacharya, S; Fu, C; Greenberg, S | 1 |
| Mercurio, AM; Shaw, LM; Turner, CE | 1 |
| Brunkhorst, B; Chen, LB; Griffin, JD; Li, JL; Lo, SH; Pisick, E; Salgia, R | 1 |
| Bellis, SL; Miller, JT; Turner, CE | 1 |
| Birge, RB; Cantley, LC; Fajardo, JE; Hanafusa, H; Reichman, C; Shoelson, SE; Songyang, Z | 1 |
| Leduc, I; Meloche, S | 1 |
| Morii, N; Narumiya, S; Rozengurt, E; Seckl, MJ | 1 |
| Leeb-Lundberg, LM; Mathis, SA; Song, XH | 1 |
| Hatanaka, M; Maki, M; Sabe, H; Yamaguchi, R | 1 |
| Rankin, S; Rozengurt, E | 1 |
| Brugge, JS; Seidel-Dugan, C; Taylor, JA; Turner, CE; Weng, Z | 1 |
| Rozengurt, E; Sinnett-Smith, J; Turner, CE; Zachary, I | 1 |
| Parsons, JT; Schaller, MD; Turner, CE | 1 |
| Lacerda, HM; Lax, AJ; Rozengurt, E | 1 |
| Broad, S; Lach, EB; Rozengurt, E | 1 |
| Parsons, T; Richardson, A | 1 |
| Feldman, EL; Leventhal, PS | 1 |
| Claesson-Welsh, L; Hooshmand-Rad, R; Rankin, S; Rozengurt, E | 1 |
| Hazeki, K; Hazeki, O; Katada, T; Sasaki, T; Ui, M | 1 |
| Broad, S; Charlesworth, A; Rozengurt, E | 1 |
| Khan, MA; Okada, M; Okumura, N | 1 |
| Bao, Z; Li, J; Zhu, Z | 1 |
| Chan-Hui, PY; Frisch, SM; Ruoslahti, E; Vuori, K | 1 |
| Haneda, M; Kikkawa, R; Shikano, T; Togawa, M | 1 |
| Geibel, J; Sumpio, BE; Yano, Y | 1 |
| Han, JD; Rubin, CS | 1 |
| Becker, E; Bershadsky, A; Chausovsky, A; Geiger, B; Lyubimova, A | 1 |
| Gunst, SJ; Pavalko, FM; Wang, Z | 1 |
| Lee, KM; Villereal, ML | 1 |
| Healy, JM; Sabe, H; Sekiguchi, K; Tanaka, T; Yamaguchi, R | 1 |
| Dolfi, F; Martin, SS; Ojaniemi, M; Olefsky, JM; Vuori, K | 1 |
| de Curtis, I; Malanchini, B | 1 |
| Feldman, EL; Kim, B; Leventhal, PS; Shelden, EA | 1 |
| Broxmeyer, HE; Gotoh, A; Ritchie, A; Takahira, H | 1 |
| Lacerda, HM; Lax, AJ; Pullinger, GD; Rozengurt, E | 1 |
| Earp, HS; Li, X | 1 |
| Cairo, S; Cattelino, A; de Curtis, I; Malanchini, B | 1 |
| Abedi, H; Zachary, I | 1 |
| Adamson, P; Cazaubon, S; Chaverot, N; Couraud, PO; Girault, JA; Romero, IA; Strosberg, AD | 1 |
| Feltkamp, CA; McCarthy, JB; Meijne, AM; Roos, E; Ruuls-Van Stalle, L | 1 |
| Jarvis, LJ; LeBien, TW; Maguire, JE | 1 |
| Garcia, LJ; Jensen, RT; Rosado, JA; Tsuda, T | 1 |
| Blakesley, VA; Butler, AA; deJong, R; Groffen, J; Koval, A; LeRoith, D | 1 |
| García, LJ; González, A; Jensen, RT; Rosado, JA | 1 |
| Bisogno, L; Frati, L; Gismondi, A; Mainiero, F; Palmieri, G; Piccoli, M; Santoni, A | 1 |
| Hildebrand, JD; Malik, RK; Parsons, JT; Richardson, A | 1 |
| Darbon, JM; Malecaze, F; Manenti, S | 1 |
| Batt, DB; Roberts, TM | 1 |
| Iwata, S; Morimoto, C; Tachibana, K | 1 |
| Fisher, SK; Linseman, DA; McEwen, EL; Sorensen, SD | 1 |
| Rodríguez-Fernández, JL; Rozengurt, E | 1 |
| Gunst, SJ; Mehta, D; Wang, Z; Wu, MF | 1 |
| Goh, EL; Lobie, PE; Zhu, T | 1 |
| Love, DC; Mentink Kane, M; Mosser, DM | 1 |
| Hunter, T; Jones, KC; Schlaepfer, DD | 1 |
| Fernandez, R; Suchard, SJ | 1 |
| Chambaz, EM; Chinn, A; Feige, JJ; Gaillard, I; Vilgrain, I | 1 |
| Haq, F; Trinkaus-Randall, V | 1 |
| Ganju, RK; Gill, P; Groopman, JE; Liu, ZY; Munshi, N; Nair, BC | 1 |
| Slack, BE | 1 |
| Hao, Q; Inagami, T; Kerins, DM; Tang, H; Vaughan, DE | 1 |
| Burridge, K; Gilmore, AP; Lohse, DL; Romer, LH; Schneider, GB | 1 |
| Bondada, S; Gao, LY; Kwaik, YA; Venkataraman, C | 1 |
| Rozengurt, E | 1 |
| Garcia, LJ; Jensen, RT; Rosado, JA; Salido, GM | 1 |
| Casamassima, A; Rozengurt, E | 1 |
| Lacoste, J; Ma, A; Parsons, JT | 1 |
| Cho, D; Fujita, H; Kamiguchi, K; Morimoto, C; Shibanuma, M; Tachibana, K | 1 |
| Anfosso, F; Bardin, N; Camoin-Jau, L; Dignat-George, F; Francès, V; Sampol, J; Vivier, E | 1 |
| Dutt, P; Groopman, JE; Wang, JF | 1 |
| Arregui, CO; Balsamo, J; Lilien, J | 1 |
| Adamson, P; Cazaubon, S; Couraud, PO; Etienne, S; Greenwood, J; Strosberg, AD | 1 |
| Goh, EL; LeRoith, D; Lobie, PE; Zhu, T | 1 |
| Bannerman, DD; Goldblum, SE; Sathyamoorthy, M | 1 |
| Hioki, K; Kameshita, I; Mohri, T; Suzuki, S; Takatani, S; Tokunaga, R | 1 |
| Bartholomew, PJ; DePasquale, JA; Vinci, JM | 1 |
| Gunst, SJ; Mehta, D; Tang, D | 1 |
| Nagai, K; Okada, M; Takayama, Y; Tanaka, S | 1 |
| Amin, S; Chandraratna, RA; De Luca, LM; Haque, M; Jones, CS; Matsukuma, K; Vuligonda, V; Zhu, WY | 1 |
| Camello, C; García, LJ; Jensen, RT; Tapia, JA | 1 |
| Nohara, K; Olivera, A; Spiegel, S; Thompson, EW; Wang, F | 1 |
| Harris, RC; Ishida, M; Kondo, S; Owada, S; Yasuda, T | 1 |
| Asai, N; Iwashita, T; Iwata, Y; Murakami, H; Narumiya, S; Takahashi, M | 1 |
| Altman, A; Deckert, M; Munshi, A; Reff, ME; Schwartz, MA; Yron, I | 1 |
| Aoki, J; Hasegawa, H; Ichikawa, A; Katoh, H; Nakamura, K; Negishi, M; Yamaguchi, Y; Yasui, H | 1 |
| Clayton, D; Padmanabhan, J; Shelanski, ML | 1 |
| Hung, MC; Lo, SH; Lo, SS; Wang, SC | 1 |
| English, D; Garcia, JG; Natarajan, V; Parinandi, NL; Scribner, WM; Vepa, S | 1 |
| Emmanouel, DS; Koukouritaki, SB; Lianos, E; Papakonstanti, EA; Stournaras, C; Vardaki, EA | 1 |
| Fuortes, M; Han, H; Lyon, GJ; Melchior, M; Nathan, C | 1 |
| Schaller, MD; Shen, Y | 1 |
| Koukouritaki, SB; Lianos, EA; Tamizuddin, A | 1 |
| Ofuji, K | 1 |
| Carbajal, JM; Schaeffer, RC | 1 |
| Chang, JS; Iwashita, S; Kim, MJ; Lee, YH; Ryu, SH; Suh, PG | 1 |
| Broome, JM; Cooley, MA; Griffin, JD; Lombardo, CR; Salgia, R; Schaller, MD; Thomas, JW | 1 |
| Ginsberg, MH; Kiosses, WB; Liu, S; Pfaff, M; Rose, DM; Thomas, SM; Woodside, DG | 1 |
| Armulik, A; Fässler, R; Johansson, S; Svineng, G; Wennerberg, K | 1 |
| Shur, BD; Wassler, MJ | 1 |
| Fukunaga, K; Horikawa, T; Ichihashi, M; Inagaki, K; Kasuga, M; Matozaki, T; Noguchi, T; Tsuda, M | 1 |
| Gravanis, A; Koukouritaki, SB; Stournaras, C | 1 |
| Ridley, AJ; Williams, LM | 1 |
| Boyer, B; Lentz, D; Petit, V; Thiery, JP; Turner, CE; Vallés, AM | 1 |
| García, LJ; Rosado, JA; Salido, GM | 1 |
| Leopoldt, D; Rozengurt, E; Saab, S; Yee, HF | 1 |
| Groopman, JE; Park, IW; Wang, JF | 1 |
| Avraham, H; Avraham, S; Park, SY | 1 |
| Byron, KL; Eble, DM; Govindarajan, G; Lou, J; Samarel, AM; Strait, JB | 1 |
| Bailey, D; Chen, LM; Fernandez-Valle, C | 1 |
| Ahn, BC; Chae, SW; Kim, HG; Kim, I; Koh, GY; Koh, KN; Moon, SO; So, JN | 1 |
| Hashimoto, S; Nakamura, K; Sabe, H; Schaefer, E; Uchida, H; Yano, H | 1 |
| Birge, RB; Chin, WG; Courtney, J; Escalante, M; Fajardo, JE; Hempstead, BL; Kim, JI; Mayer, BJ; Teng, KK | 1 |
| Basson, MD; Sanders, MA; Yu, CF | 1 |
| Armulik, A; Fässler, R; Johansson, S; Karlsson, M; Mosher, DF; Sakai, T; Schaefer, EM; Wennerberg, K | 1 |
| Carbajal, JM; Gratrix, ML; Schaeffer, RC; Yu, CH | 1 |
| Cornell-Bell, A; Kewalramani, R; Payne, J; Trinkaus-Randall, V | 1 |
| Atkinson, S; Gunst, SJ; Mehta, D; Tang, DD; Wu, MF | 1 |
| Akedo, H; Hashimoto, S; Iwasaki, T; Mukai, M; Nakamura, K; Sabe, H; Uchida, H; Yano, H | 1 |
| Calvo, JJ; García-Benito, M; García-Marín, LJ; López, MA; San Román, JI | 1 |
| Chung, HT; Jeong, SM; Kim, KS; Kim, PH; Lee, JH; Ryu, H | 1 |
| Baron, R; Horne, WC; Zhang, Z | 1 |
| Kwaik, YA; Venkataraman, C | 1 |
| Akedo, H; Ayaki, M; Imamura, F; Mukai, M | 1 |
| Howe, AK; Juliano, RL | 1 |
| Brümmer, J; Ebrahimnejad, A; Flayeh, R; Unteregger, G; Wagener, C | 1 |
| Baba, A; Hashimoto, H; Koyama, Y; Matsuda, T; Yoshioka, Y | 1 |
| da Costa, SR; Hamm-Alvarez, SF; Schönthal, AH; Vilalta, PM; Wang, Y | 1 |
| Bett, AJ; Duong, LT; Lakkakorpi, PT; Lipfert, L; Nakamura, I; Rodan, GA | 1 |
| Duong, LT; Lakkakorpi, PT; Lipfert, L; Nakamura, I; Rodan, GA; Young, M | 1 |
| Garcia-Marin, LJ; Jensen, RT; Leyton, J; Moody, TW; Tapia, JA | 1 |
| Ballard, G; Harrington, EO; Newton, J; Rounds, S; Smeglin, A | 1 |
| Al-Okla, S; Chatenay-Rivauday, C; Klein, JP; Wachsmann, D | 1 |
| Condeelis, JS; Lee, PS; Pixley, FJ; Stanley, ER | 1 |
| Hosogaya, S; Ohmori, T; Osada, M; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Arai, H; Ashida, N; Ishii, K; Kita, T; Yamasaki, M | 1 |
| Guan, JL; Han, DC; Rodriguez, LG | 1 |
| Burns, KD; Chen, JK; Harris, RC; Zimpelmann, J | 1 |
| Davis, GE; Davis, MJ; Meininger, GA; Wilson, E; Wu, X | 1 |
| Nakamura, K; Sabe, H; Schaefer, E; Yano, H | 1 |
| Davies, G; Jiang, WG; Mason, MD; Matsumoto, K; Nakamura, T; Parr, C | 1 |
| Gunst, SJ; Tang, DD | 1 |
| Berrou, E; Bryckaert, M | 1 |
| Aoyagi, K; Kondo, S; Ohnishi, H; Ono, K; Takahashi, M; Yamamori, S | 1 |
| Jope, RS; Tucholski, J; Watcharasit, P | 1 |
| Kucik, DF; Li, J; Zhou, X | 1 |
| Ebner, S; Kruse, FE; You, L | 1 |
| Maddala, RL; Rao, PV; Reddy, VN | 1 |
| Jurdic, P; Pfaff, M | 1 |
| Begg, D; Berthiaume, LG; Bourgoin, S; Brindley, DN; Hanna, AN; Kikuchi, Y | 1 |
| Schaefer, EM; Schaller, MD | 1 |
| Akedo, H; Iwasaki, T; Kakishita, E; Mukai, M; Nakata, A; Sabe, H; Schaefer, E; Shinkai, K; Tatsuta, M; Terada, N; Tsujimura, T; Yano, H | 1 |
| Panetti, TS | 1 |
| Cantley, LG; Liu, ZX; Nickel, C; Thomas, S; Yu, CF | 1 |
| George, EL; Hagel, M; Imamoto, A; Kim, A; Opitz, SL; Tamimi, R; Thomas, SM; Turner, CE | 1 |
| Hanks, SK; Roy, S; Ruest, PJ | 1 |
| Crowe, SM; Ellery, P; Jaworowski, A; Kedzierska, K; Lewin, SR; Mak, J | 1 |
| Gabarra-Niecko, V; Keely, PJ; Schaller, MD | 1 |
| Arold, ST; Hoellerer, MK; Noble, ME | 1 |
| Du, ZY; Jin, YP; Rajasekaran, AK; Reed, EF; Rozengurt, E; Singh, RP | 1 |
| Avraham, H; Avraham, S; Fu, Y; McShan, GD; Park, SY; Zagozdzon, R; Zrihan-Licht, S | 1 |
| Jin, T; Li, J | 1 |
| Carter, N; Hirai, H; Hunter, T; Nakamoto, T | 1 |
| Abassi, YA; Vuori, K | 1 |
| Itoh, H; Kent, KC; Kubota, K; Liu, B; Louie, O | 1 |
| Ikebuchi, Y; Kawagishi, R; Morishige, K; Murata, Y; Sawada, K; Tahara, M; Tasaka, K | 1 |
| Mazaki, Y; Sabe, H; Sakakura, J; Schaefer, E; Tsubouchi, A; Yagi, R; Yano, H | 1 |
| Ikebuchi, Y; Kawagishi, R; Morishige, Ki; Murata, Y; Sawada, K; Tahara, M; Tasaka, K | 1 |
| Bhattacharya, J; Bhattacharya, S; Issekutz, AC; Parthasarathi, K; Patel, R; Quadri, S; Sen, N; Yiming, MT | 1 |
| Hunger-Glaser, I; Rozengurt, E; Salazar, EP | 1 |
| Bershadsky, AD; Geiger, B; Kam, Z; Kirchner, J; Tzur, G | 1 |
| Akira, S; Funami, K; Hazeki, K; Hazeki, O; Masuda, N; Matsumoto, M; Seya, T; Sukenobu, N; Takeda, K | 1 |
| Ahn, BH; Chang, JS; Choi, KS; Jo, YH; Kim, EH; Kim, MS; Kim, SY; Kwon, TK; Lee, YH; Min, DS | 1 |
| Aiso, S; Hiraoka, Y; Ogawa, M | 1 |
| Aingorn, H; Cohen, I; Cohen, M; Geiger, B; Goldshmidt, O; Katz, BZ; Nadav, L; Vlodavsky, I; Zcharia, E | 1 |
| Bill, HM; Galante, LM; Mack, CP; Sundberg, LJ; Taylor, JM | 1 |
| Araki, M; Matsumoto, K; Miyamori, H; Sato, H; Takino, T; Tamura, M; Yamada, KM | 1 |
| Davies, G; Jiang, WG; Lane, J; Mansel, RE; Martin, TA; Matsumoto, K; Nakamura, T; Parr, C; Watkins, G | 1 |
| Avraham, HK; Avraham, S; Jiang, S; Kim, TA; Koh, Y; Lee, TH; Samarel, AM; Sussman, M | 1 |
| Burkin, D; Kaufman, SJ; Li, J; Rao, H; Wu, C | 1 |
| Gunst, SJ; Tang, DD; Turner, CE | 1 |
| Alimenti, E; Della Morte, R; Ferrante, MC; Lucisano, A; Naso, B; Scibelli, A; Staiano, N; Tafuri, S | 1 |
| Berenstein, E; da Silva Trindade, E; Jamur, MC; Oliver, C; Pastor, MV; Siraganian, RP; Vial, D; Zhang, J | 1 |
| Avraham, HK; Avraham, S; Fu, Y; Jiang, S; Zrihan-Licht, S | 1 |
| Birukov, KG; Birukova, AA; Garcia, JG; Shikata, Y; Verin, A | 1 |
| Otte, JM; Schmidt, WE; Schmitz, F; Schrader, H; Yu, HG | 1 |
| Beinke, C; Cordes, N; Van Beuningen, D | 1 |
| Birukov, KG; Bochkov, VN; Garcia, JG; Leitinger, N | 1 |
| Claesson-Welsh, L; Cross, MJ; Hägerkvist, R; Holmqvist, K; Matsumoto, T; Rahimi, N; Rolny, C; Welsh, M | 1 |
| Cerretti, DP; Huynh-Do, U; Teli, T; Turner, CE; Vindis, C | 1 |
| Kobayashi, H; Matozaki, T; Ohe, Y; Ohnishi, H; Okazawa, H; Sato, R; Tomizawa, K | 1 |
| Hirakawa, M; Ito, Y; Karashima, Y; Oike, M | 1 |
| Avraham, HK; Avraham, S; Park, SY | 1 |
| Cartwright, CA; Chang, BY; Harte, RA; Lee, KC; Mamidipudi, V | 1 |
| Nomoto, A; Oda, T; Ohka, S | 1 |
| Houle, F; Huot, J; Le Boeuf, F | 1 |
| Blagosklonny, MV; Chay, KO; Hashimoto, S; Mushinski, JF; Romanova, LY; Sabe, H | 1 |
| Lunn, JA; Rozengurt, E | 1 |
| Beuvin, M; Boyer, B; Vallés, AM | 1 |
| Cordes, N | 1 |
| Avraham, H; Melendez, J; Schaefer, E; Steinberg, SF; Sussman, MA; Turner, C | 1 |
| Barwe, SP; Jin, YP; Lepin, EJ; Reed, EF; Rozengurt, E | 1 |
| Chen, GY; Maeda, N; Muramatsu, H; Muramatsu, T; Noda, M; Oda, Y; Sakaguchi, N; Sakuma, S; Suzuki, H; Takada, Y; Zou, P | 1 |
| Cohen, LA; Guan, JL | 1 |
| Enns, A; Fisch, KM; Gassmann, P; Haier, J; Nicolson, GL; von Sengbusch, A | 1 |
| Chiariotti, L; Florio, T; Fusco, A; Iuliano, R; Pera, IL; Santoro, M; Schettini, G; Susini, C; Trapasso, F; Viglietto, G | 1 |
| Basson, MD; Sanders, MA | 1 |
| Gunst, SJ; Tang, DD; Zhang, W | 1 |
| Chang, WK; Cho, DY; Han, JW; Jung, ID; Kim, YK; Lee, HW; Lee, HY; Lee, J; Park, CG; Seo, DW; Shin, EY | 1 |
| Cramer, T; Herzig, KH; Höcker, M; Mergler, S; Müerköster, S; Schäfer, H; Schmidt, WE; Schmitz, F; Yu, HG | 1 |
| Brábek, J; Constancio, SS; Hanks, SK; Pozzi, A; Shin, NY; Siesser, PF | 1 |
| Chen, TC; Markland, FS; Schmitmeier, S; Schönthal, AH | 1 |
| Brown, MC; Cary, LA; Cooper, JA; Jamieson, JS; Turner, CE | 1 |
| Furukawa, K; Hamamura, K; Hattori, H; Hattori, T; Hayashi, T; Lloyd, KO; Mizutani, H; Nakano, J; Nakashima, H; Okuda, T; Ueda, M; Urano, T | 1 |
| Chang, LC; Chen, BH; Chen, HC; Cheng, CH; Huang, CH | 1 |
| Hetey, SE; Lalonde, DP; Turner, CE | 1 |
| Avraham, S; Park, SY; Schinkmann, KA | 1 |
| Chow, CW; Downey, GP; Herrera Abreu, MT; Hong, O; McCulloch, CA; Suzuki, T; Vachon, E; Villar, J; Wang, Q; Wang, Y | 1 |
| Brame, CJ; Horwitz, AR; Hunt, DF; Schroeder, MJ; Shabanowitz, J; Webb, DJ; Whitmore, L | 1 |
| Kannicht, C; Klaile, E; Lucka, L; Müller, MM; Singer, BB | 1 |
| Ascoli, M; Mizutani, T; Shiraishi, K; Welsh, T | 1 |
| Böcker, U; Feick, P; Haas, SR; Singer, MV | 1 |
| Addadi, L; Geiger, B; Luxenburg, C | 1 |
| Ballestrem, C; Bershadsky, A; Erez, N; Geiger, B; Kam, Z; Kirchner, J | 1 |
| Chang, H; Diaz, T; Noda, M; Oh, J; Stetler-Stevenson, WG; Wei, B | 1 |
| Chen, M; Chen, SC; Pallen, CJ | 1 |
| Cai, X; Li, M; Schaller, MD; Vrana, J | 1 |
| Elkaim, R; Obrecht-Pflumio, S; Tenenbaum, H | 1 |
| Cave, CM; Lentsch, AB; Matlin, K; Robinson, CT; Solomkin, JS; Umanskiy, K; Williams, MA | 1 |
| Yano, H | 1 |
| Achuthan, A; Elsegood, C; Hamilton, JA; Masendycz, P; Scholz, GM | 1 |
| Hao, Q; Low, B; Rutherford, SA; Tang, H | 1 |
| Chien, S; Haga, JH; Hu, YL; Li, YS; Miao, H; Wang, Y | 1 |
| Gomez, TM; Robles, E | 1 |
| Geiger, B; Kam, Z; Milo, R; Zaidel-Bar, R | 1 |
| Aixinjueluo, W; Furukawa, K; Hamamura, K | 1 |
| Hattori, A; Kawamoto, K; Kimura, K; Kitazawa, K; Naganuma, M; Nishida, T; Nomizu, M; Teranishi, S; Usui, Y | 1 |
| Chen, HI; Jen, CJ; Su, WH | 1 |
| Han, S; Rembold, CM; Ripley, ML; Tejani, AD | 1 |
| Alderliesten, M; de Graauw, M; Oldenampsen, J; Pont, C; Qin, Y; van Buren, L; van de Water, B | 1 |
| Bell, SA; Goss, JL; Khoury, JBE; Moore, KJ; Richard, J; Silver, JM; Stewart, CR; Stuart, LM; Tseng, AA; Zhang, A | 1 |
| Alpern, RJ; Huang, HC; Preisig, PA; Yang, X; Yin, H | 1 |
| Baran, J; Hancock, JF; Hill, MM; Huber, LA; Parat, MO; Parton, RG; Scherbakov, N; Schiefermeier, N | 1 |
| Bernard-Trifilo, JA; Bokoch, G; Canete-Soler, R; Chen, XL; Gardel, M; Ilic, D; Lim, ST; Lim, Y; Lin, H; Nalbant, P; Schlaepfer, DD; Schlaepfer, WW; Tomar, A; Uryu, SA; Waterman-Storer, C; Zhai, J | 1 |
| Basson, MD; Craig, DH; Downey, C | 1 |
| Barlati, S; Colombi, M; Zoppi, N | 1 |
| Brown, CM; Easley, CA; Horwitz, AF; Tombes, RM | 1 |
| Albitar, L; Aponte, M; Cramer, DW; Edwards, D; Jiang, W; Lakkis, M; Li, MJ; Mok, SC; Vitonis, A; Ye, B | 1 |
| Das, A; Mehta, D; Shah, VH; Yaqoob, U | 1 |
| Chan, KT; Cortesio, CL; Huttenlocher, A | 1 |
| Chu, PY; Guan, JL; Hsu, CH; Huang, LY; Hung, TH; Liang, CC; Shen, TL | 1 |
| Miyasaka, M; Moriwaki, K; Murata, S; Tanaka, T | 1 |
| Fujinaka, H; Harita, Y; Ikeda, T; Magdeldin, S; Mohamed, SM; Nameta, M; Taguchi, I; Tsukaguchi, H; Xu, B; Yamamoto, T; Yaoita, E; Yoshida, Y; Zhang, Y | 1 |
| Asano, M; Dawson, D; Guda, K; Iwakura, Y; Lawrence, E; Markowitz, SD; Satake, M; Sun, Q; Wang, Z; Watanabe, T; Wei, L; Willis, J; Yang, Z; Zhang, X; Zhao, Y; Zheng, W | 1 |
| Chacón, MR; Fernández, G; Rico, B | 1 |
| Basuroy, S; Dunagan, M; Rao, RK; Seth, A; Sheth, P | 1 |
| Bartelt, RR; Collins, M; Houtman, JC | 1 |
| Cheng, L; Cheng, R; Hu, T; Shao, MY; Wang, FM; Yang, H; Zhou, XD | 1 |
| Kasahara, K; Sekino-Suzuki, N; Yamamoto, N; Yuyama, K | 1 |
| Long, EO; March, ME | 1 |
| De Mey, J; Deramaudt, TB; Dujardin, D; Hamadi, A; Kolli, K; Noulet, F; Rondé, P; Takeda, K | 1 |
| Jensen, RT; Leyton, J; Moody, TW | 1 |
| Brimer, N; Lyons, C; Pol, SV; Wade, R | 1 |
| Chang, JL; Chang, SW; Chen, TC; Lai, CH | 1 |
| Furukawa, K; Hamamura, K; Hattori, H; Hotta, H; Matsumoto, Y; Nishida, Y; Shibuya, H; Ueda, M | 1 |
| Bristow, JM; Gonias, SL; Jo, M; Klemke, RL; Reno, TA | 1 |
| Augustin, H; Ditkowski, B; Eble, JA; Niland, S; Parrandier, D; Roth, L | 1 |
| Alford, SK; Feng, Y; Longmore, GD; Ngu, H; Ward, M; Yin, F | 1 |
| Cheng, HY; Cioce, M; Gokhan, S; Halenbeck, R; Hsu, AW; Lin, H; Mehler, MF; Nandi, S; Nieves, E; Stanley, ER; Tesfa, L; Yeung, YG | 1 |
| Cheng, SY; Pallen, CJ; Schlaepfer, DD; Sun, G | 1 |
| Cheong, C; Reizis, B; Rhee, I; Veillette, A; Zhong, MC | 1 |
| Astro, V; de Curtis, I; Tonoli, D; Totaro, A | 1 |
| Bálint, Z; Dahal, BK; Kwapiszewska, G; Murmann, K; Schermuly, RT; Seeger, W; Veith, C; Weissmann, N; Wygrecka, M; Zakrzewicz, D | 1 |
| Guan, JL; Qu, H; Tu, Y; Wu, C; Xiao, G | 1 |
| De Las Casas, LE; Diakonova, M; Hammer, A; Oladimeji, P | 1 |
| Fujikawa, A; Kuboyama, K; Matsumoto, M; Noda, M; Suzuki, R | 1 |
| Aragay, AM; Cordomí, A; Garrido, G; Gigoux, V; Izquierdo, I; Masià-Balagué, M; Miller, NL; Pérez-Benito, L; Schlaepfer, DD | 1 |
| Ding, S; Ma, P; Shen, D; Wei, C; Wu, Y; Yang, X; Yuan, J; Zhao, Y | 1 |
| Chen, RQ; Gao, CQ; Jin, CL; Li, HC; Wang, D; Wang, XQ; Yan, HC | 1 |
| Cai, QQ; Chen, Q; Deng, NH; Dong, YW; Jin, YT; Li, C; Qi, B; Wang, R; Wu, XZ | 1 |
| Fermin, Y; Grecco, HE; Harizanova, J; Ickstadt, K; Malik-Sheriff, RS; Wieczorek, J; Zamir, E | 1 |
| Maddala, R; Rao, PV; Skiba, NP | 1 |
| Dai, C; Xiao, J; Yu, Z; Zhong, R | 1 |
| Chao, WT; Chen, HY; Chen, YR; Chou, HC; Chuang, HC; Lin, TY; Liu, YW; Tan, TH; Tsou, HH; Yang, CH; Yeh, CL | 1 |
| Baruzzi, A; Ferrarini, F; Liboi, E; Lievens, PM; Montone, R; Romanelli, MG | 1 |
| Baumgart, T; Blumenthal, D; Burkhardt, JK; Chandra, V; Jankowska, KI; Roy, NH; Williamson, EK | 1 |
| Bello-Alvarez, C; Camacho-Arroyo, I; González-Arenas, A; Moral-Morales, AD | 1 |
| Cress, AE; Epshtein, Y; Fu, P; Garcia, JGN; Jacobson, J; Mascarenhas, JB; Natarajan, V; Ramchandran, R | 1 |
| Diop, A; Gianni, S; Malagrinò, F; Marcocci, L; Nardella, C; Pagano, L; Pennacchietti, V; Pietrangeli, P; Santorelli, D; Toto, A | 1 |
| Kishi, H; Kobayashi, S; Maeda, N; Nagano, H; Tsunedomi, R; Xu, M; Zhang, Y; Zheng, H | 1 |
7 review(s) available for paxilline and tyrosine
| Article | Year |
|---|---|
Paxillin: a cytoskeletal target for tyrosine kinases.
Topics: Animals; Cell Adhesion; Cytoskeletal Proteins; Cytoskeleton; Embryonic and Fetal Development; Extracellular Matrix; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vinculin | 1994 |
VLA-4-mediated signaling.
Topics: Amino Acid Sequence; Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin alpha4beta1; Integrins; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptors, Lymphocyte Homing; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Signal Transduction; T-Lymphocytes; Tyrosine | 1998 |
Tyrosine phosphorylation in the action of neuropeptides and growth factors.
Topics: Animals; Cell Adhesion Molecules; Cell Division; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Substances; Humans; Lysophospholipids; Neuropeptides; Paxillin; Phosphoproteins; Phosphorylation; Phosphorylcholine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Sphingosine; Tyrosine | 1997 |
V. Gastrointestinal peptide signaling through tyrosine phosphorylation of focal adhesion proteins.
Topics: Animals; Cell Adhesion Molecules; Cell Division; Cell Movement; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Digestive System Physiological Phenomena; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrointestinal Hormones; GTP-Binding Proteins; Humans; Models, Biological; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine | 1998 |
Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration.
Topics: Animals; Cell Movement; Cell Size; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Tyrosine | 2002 |
[Signal crosstalk between cell-substratum adhesion and cell-cell adhesion].
Topics: Animals; Cell Adhesion; Crk-Associated Substrate Protein; Focal Adhesion Kinase 1; Humans; Paxillin; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; rap1 GTP-Binding Proteins; Signal Transduction; Tyrosine | 2006 |
Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy.
Topics: Anoikis; Antibodies, Monoclonal; Carcinoma, Small Cell; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Glycosphingolipids; Humans; Lung Neoplasms; Melanoma; Neoplasm Invasiveness; Paxillin; Phosphorylation; Tyrosine | 2006 |
303 other study(ies) available for paxilline and tyrosine
| Article | Year |
|---|---|
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.
Topics: 3T3 Cells; Animals; Benzoquinones; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Lactams, Macrocyclic; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1992 |
Paxillin is a major phosphotyrosine-containing protein during embryonic development.
Topics: Animals; Chick Embryo; Cytoskeletal Proteins; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Tissue Distribution; Tyrosine | 1991 |
CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cytoskeletal Proteins; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nuclear Proteins; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.
Topics: Actins; Animals; Chromatography, Affinity; Cytochalasin D; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Macromolecular Substances; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Models, Biological; Molecular Weight; Paxillin; Phagocytosis; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Tyrosine | 1994 |
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cytoskeletal Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Insulin; Membrane Proteins; Molecular Weight; Nerve Growth Factors; Neurons; Oncogene Protein v-crk; Paxillin; PC12 Cells; Phosphoproteins; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptors, Nerve Growth Factor; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 1994 |
Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1994 |
Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.
Topics: Animals; Base Sequence; Cell Adhesion Molecules; Cell Line; Chick Embryo; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; DNA Primers; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; src-Family Kinases; Structure-Activity Relationship; Tyrosine | 1994 |
Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin.
Topics: 3T3 Cells; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Base Sequence; Bombesin; Botulinum Toxins; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Mice; Molecular Sequence Data; Molecular Weight; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; rho GTP-Binding Proteins; Signal Transduction; Tyrosine | 1994 |
Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intercellular Junctions; Mice; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Sphingosine; Terpenes; Thapsigargin; Tyrosine | 1994 |
Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils.
Topics: Adolescent; Adult; CD18 Antigens; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Extracellular Matrix Proteins; Female; Humans; In Vitro Techniques; Integrins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Paxillin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Complement; Signal Transduction; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor.
Topics: CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Child; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Neutrophils; Paxillin; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Adhesion Molecules; Chick Embryo; Consensus Sequence; Cytoskeletal Proteins; DNA, Complementary; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes; Microscopy, Fluorescence; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine; Vinculin | 1994 |
Matrix nonenzymatic glycosylation leads to altered cellular phenotype and intracellular tyrosine phosphorylation.
Topics: Animals; Basement Membrane; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycosylation; Humans; Kinetics; Mice; Mice, Inbred BALB C; Microcirculation; Neoplasms, Experimental; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Skin; Tyrosine | 1995 |
Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction.
Topics: Acetylcholine; Animals; Binding Sites; Cytoskeletal Proteins; Dogs; Immunosorbent Techniques; Muscle Contraction; Muscle, Smooth; Paxillin; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Talin; Trachea; Tyrosine; Vinculin | 1995 |
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.
Topics: 3T3 Cells; Actins; Animals; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fungal Proteins; GTP Phosphohydrolases; GTP-Binding Proteins; Membrane Proteins; Mice; Microinjections; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pseudopodia; rac GTP-Binding Proteins; Recombinant Fusion Proteins; rhoB GTP-Binding Protein; Signal Transduction; Tyrosine; Vinculin | 1995 |
Nerve growth factor stimulates tyrosine phosphorylation of paxillin in PC12h cells.
Topics: Animals; Blotting, Western; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Immunosorbent Techniques; Kinetics; Nerve Growth Factors; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Signal Transduction; Tyrosine | 1995 |
Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Becaplermin; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rats; Receptor, Insulin; Recombinant Proteins; Stress, Mechanical; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1995 |
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Adhesion Molecules; Chick Embryo; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Models, Molecular; Molecular Sequence Data; Oncogene Protein v-crk; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins, Oncogenic; Substrate Specificity; Tyrosine | 1995 |
Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Actins; Animals; Aorta; Becaplermin; Cell Adhesion Molecules; Cell Division; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kinetics; Mice; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rabbits; Receptor, Insulin; Recombinant Proteins; Tunica Media; Tyrosine | 1995 |
Bradykinin induces tyrosine phosphorylation of epidermal growth factor-receptor and focal adhesion proteins in human keratinocytes.
Topics: Alkaloids; Bradykinin; Cell Adhesion Molecules; Cell Line; Chromatography, Affinity; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Immunoblotting; Indoles; Isoflavones; Keratinocytes; Maleimides; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Bradykinin; Staurosporine; Tyrosine | 1995 |
Soluble ligands of the alpha v beta 3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Complement Membrane Attack Complex; Cytoskeletal Proteins; Endothelium, Vascular; Glycoproteins; Heparin; Integrins; Oligopeptides; Paxillin; Phosphoproteins; Phosphorylation; Pulmonary Artery; Receptors, Cytoadhesin; Receptors, Vitronectin; Tyrosine; Vitronectin | 1995 |
The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cytoplasm; Cytoskeletal Proteins; Genetic Variation; Humans; Integrin alpha6beta1; Integrins; Laminin; Mice; Paxillin; Phosphoproteins; Phosphorylation; Proteins; Signal Transduction; Transfection; Tyrosine | 1995 |
Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fusion Proteins, bcr-abl; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Microfilament Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rabbits; Talin; Tensins; Tyrosine; Vinculin | 1995 |
Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Adhesion Molecules; Chick Embryo; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine | 1995 |
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Blotting, Western; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; In Vitro Techniques; Molecular Sequence Data; Oligopeptides; Oncogene Protein v-crk; Oncogenes; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Binding; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Tyrosine; Vanadates | 1993 |
Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells.
Topics: Angiotensin I; Angiotensin II; Animals; Aorta; Cell Adhesion Molecules; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Male; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Rats; Receptors, Angiotensin; Tyrosine | 1995 |
Guanosine 5'-3-O-(thio)triphosphate stimulates tyrosine phosphorylation of p125FAK and paxillin in permeabilized Swiss 3T3 cells. Role of p21rho.
Topics: 3T3 Cells; Animals; Base Sequence; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Magnesium; Mice; Molecular Sequence Data; Molecular Weight; Paxillin; Permeability; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Tyrosine | 1995 |
Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bradykinin; Calcium; Cell Adhesion Molecules; Chelating Agents; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTPase-Activating Proteins; Isoquinolines; Mice; Paxillin; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Unphosphorylated and tyrosine-phosphorylated forms of a focal adhesion protein, paxillin, are substrates for calpain II in vitro: implications for the possible involvement of calpain II in mitosis-specific degradation of paxillin.
Topics: 3T3 Cells; Animals; Calpain; Cell Adhesion Molecules; Cytoskeletal Proteins; Humans; Mice; Mitosis; Paxillin; Phosphoproteins; Phosphorylation; Tyrosine | 1994 |
Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.
Topics: 3T3 Cells; Actins; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Drug Interactions; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTPase-Activating Proteins; Mice; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; Type C Phospholipases; Tyrosine | 1994 |
Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Cell Line, Transformed; Cytoskeletal Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oncogene Protein pp60(v-src); Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Tyrosine | 1993 |
Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium; Cytochalasin D; Cytoskeletal Proteins; Endothelins; Enzyme Activation; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Signal Transduction; Tyrosine; Vasopressins | 1993 |
Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Chick Embryo; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Time Factors; Tissue Distribution; Tyrosine | 1993 |
Pasteurella multocida toxin, a potent intracellularly acting mitogen, induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.
Topics: 3T3 Cells; Actins; ADP Ribose Transferases; Animals; Bacterial Proteins; Bacterial Toxins; Botulinum Toxins; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Microinjections; Mitogens; Pasteurella multocida; Paxillin; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Tyrosine | 1996 |
Mitogenic signaling by transfected neuromedin B receptors in Rat-1 cells.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Division; Cell Line; Cytoskeletal Proteins; DNA; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mitogens; Myristoylated Alanine-Rich C Kinase Substrate; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Rats; Receptor, Insulin; Receptors, Bombesin; Signal Transduction; Transfection; Tyrosine | 1995 |
A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.
Topics: Animals; Binding, Competitive; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chickens; Cytoskeletal Proteins; Enzyme Activation; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Microfilament Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tensins; Transfection; Tyrosine | 1996 |
Tyrosine phosphorylation and enhanced expression of paxillin during neuronal differentiation in vitro.
Topics: Actins; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cell Line; Cytoskeletal Proteins; Humans; In Vitro Techniques; Laminin; Neurites; Neurons; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Tyrosine | 1996 |
Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mutagenesis, Site-Directed; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 1996 |
Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Androstadienes; Animals; Cell Adhesion Molecules; Ceramides; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Signal Transduction; Sphingomyelin Phosphodiesterase; Substrate Specificity; Tyrosine; Wortmannin | 1996 |
The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation, tyrosine phosphorylation of p125FAK and paxillin and cell proliferation.
Topics: Animals; Bombesin; Cell Adhesion Molecules; Cell Division; Cells, Cultured; Cytoskeletal Proteins; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptors, Bombesin; Signal Transduction; Stimulation, Chemical; Transfection; Type C Phospholipases; Tyrosine | 1996 |
Depolarization-induced tyrosine phosphorylation of paxillin in PC12h cells.
Topics: Animals; Blotting, Western; Cytochalasin D; Cytoskeletal Proteins; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Potassium Chloride; Rats; Tyrosine | 1996 |
Role of MacMARCKS in integrin-dependent macrophage spreading and tyrosine phosphorylation of paxillin.
Topics: Amino Acid Sequence; CD18 Antigens; Cell Line; Cell Membrane; Cell Movement; Cytoskeletal Proteins; Macrophages; Membrane Proteins; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Proteins; Tyrosine | 1996 |
Control of adhesion-dependent cell survival by focal adhesion kinase.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; CD2 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Dogs; Enzyme Activation; Epithelial Cells; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kidney; Mice; Mice, Nude; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Recombinant Fusion Proteins; Tyrosine | 1996 |
[Tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin in glomeruli from diabetic rats].
Topics: Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Mesangium; Male; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain.
Topics: Animals; Aorta; Cattle; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Isoflavones; Nitriles; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Stress, Mechanical; Tissue Distribution; Tyrosine; Tyrphostins | 1996 |
Regulation of cytoskeleton organization and paxillin dephosphorylation by cAMP. Studies on murine Y1 adrenal cells.
Topics: Actins; Adrenal Cortex Neoplasms; Animals; Cell Adhesion Molecules; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Isoflavones; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine; Vanadates | 1996 |
Involvement of microtubules in the control of adhesion-dependent signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actin Cytoskeleton; Alkaloids; Animals; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; DNA; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Indoles; Integrins; Isoflavones; Mice; Microtubules; Myosin-Light-Chain Kinase; Nocodazole; Paclitaxel; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vinblastine | 1996 |
Tyrosine phosphorylation of the dense plaque protein paxillin is regulated during smooth muscle contraction.
Topics: Acetylcholine; Analysis of Variance; Animals; Blotting, Western; Cytoskeletal Proteins; Dogs; Genistein; In Vitro Techniques; Isoflavones; Isometric Contraction; Kinetics; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Serotonin; Trachea; Tyrosine | 1996 |
Tyrosine phosphorylation and activation of pp60c-src and pp125FAK in bradykinin-stimulated fibroblasts.
Topics: Bradykinin; Cell Adhesion Molecules; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Oncogene Protein pp60(v-src); Paxillin; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Time Factors; Tyrosine | 1996 |
Paxillin association in vitro with integrin cytoplasmic domain peptides.
Topics: Amino Acid Sequence; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cytoplasm; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Molecular Sequence Data; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Tyrosine | 1996 |
The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.
Topics: Animals; Cell Adhesion; Cytoskeletal Proteins; Genes, src; Integrins; Mice; Microfilament Proteins; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; src Homology Domains; Tensins; Tyrosine; Ubiquitin-Protein Ligases | 1997 |
Integrin-mediated tyrosine phosphorylation and redistribution of paxillin during neuronal adhesion.
Topics: Animals; Antibodies; Cell Adhesion; Cell Adhesion Molecules; Cell Extracts; Cells, Cultured; Chick Embryo; Cross-Linking Reagents; Cytoskeletal Proteins; Cytoskeleton; Digitonin; Integrin beta1; Integrins; Laminin; Neurites; Neurons; Paxillin; Phosphoproteins; Phosphorylation; Receptors, Laminin; Retina; Saponins; Signal Transduction; Tyrosine | 1997 |
Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance.
Topics: Cell Adhesion Molecules; Cell Size; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor I; Neuroblastoma; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1997 |
Steel factor enhances integrin-mediated tyrosine phosphorylation of focal adhesion kinase (pp125FAK) and paxillin.
Topics: Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Stem Cell Factor; Tyrosine | 1997 |
Cytotoxic necrotizing factor 1 from Escherichia coli and dermonecrotic toxin from Bordetella bronchiseptica induce p21(rho)-dependent tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 cells.
Topics: 3T3 Cells; Actins; Animals; Bacterial Toxins; Bordetella; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytotoxins; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Inositol Phosphates; Mice; Mitogen-Activated Protein Kinase 1; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; rho GTP-Binding Proteins; Transglutaminases; Tyrosine; Virulence Factors, Bordetella | 1997 |
Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells.
Topics: Amino Acid Sequence; Animals; Calcium; Cells, Cultured; Cytoskeletal Proteins; Epithelium; Liver; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Tyrosine | 1997 |
Preferential localization of tyrosine-phosphorylated paxillin in focal adhesions.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Chick Embryo; Cytoskeletal Proteins; Focal Adhesion Protein-Tyrosine Kinases; Integrin beta1; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine | 1997 |
Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells.
Topics: Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Lymphokines; Maleimides; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways.
Topics: Actins; Adaptor Proteins, Signal Transducing; Aluminum Compounds; Animals; Astrocytes; Cell Adhesion Molecules; Cell Division; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Cytoskeletal Proteins; Cytoskeleton; DNA; Endothelin-1; ErbB Receptors; Fetus; Fluorides; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; GTP-Binding Proteins; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Rabbits; Rats; rho GTP-Binding Proteins; Signal Transduction; src Homology Domains; src-Family Kinases; Stress, Mechanical; Tyrosine | 1997 |
v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions.
Topics: Actin Cytoskeleton; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Size; Cell Transformation, Neoplastic; Cytoskeletal Proteins; DNA-Binding Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fusion Proteins, gag-onc; Guanine Nucleotide Exchange Factors; Mutation; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Oncogene Protein pp60(v-src); Paxillin; Phosphoproteins; Phosphorylation; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; Repressor Proteins; RNA-Binding Proteins; Temperature; Transcription, Genetic; Tyrosine | 1997 |
Contact between human bone marrow stromal cells and B lymphocytes enhances very late antigen-4/vascular cell adhesion molecule-1-independent tyrosine phosphorylation of focal adhesion kinase, paxillin, and ERK2 in stromal cells.
Topics: B-Lymphocytes; Bone Marrow Cells; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin alpha4beta1; Integrins; Lymphoma, B-Cell; Mitogen-Activated Protein Kinase 1; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Lymphocyte Homing; Stromal Cells; Tumor Cells, Cultured; Tyrosine; Vascular Cell Adhesion Molecule-1 | 1997 |
CCK causes rapid tyrosine phosphorylation of p125FAK focal adhesion kinase and paxillin in rat pancreatic acini.
Topics: Animals; Cell Adhesion Molecules; Cholecystokinin; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Male; Pancreas; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tyrosine | 1997 |
In vivo regulation of CrkII and CrkL proto-oncogenes in the uterus by insulin-like growth factor-I. Differential effects on tyrosine phosphorylation and association with paxillin.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cytoskeletal Proteins; Estrogens; Female; Gene Expression Regulation, Developmental; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Mice; Nuclear Proteins; Ovariectomy; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Tyrosine; Uterus | 1997 |
Cholecystokinin-stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho.
Topics: Actins; Animals; Calcimycin; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Indoles; Inositol Phosphates; Kinetics; Male; Maleimides; Models, Biological; Pancreas; Paxillin; Phospholipases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; rho GTP-Binding Proteins; Sincalide; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Proline-rich tyrosine kinase-2 activation by beta 1 integrin fibronectin receptor cross-linking and association with paxillin in human natural killer cells.
Topics: Animals; Antigen-Antibody Complex; Calcium; Cytoskeletal Proteins; Focal Adhesion Kinase 2; Humans; Integrin alpha4beta1; Integrins; Jurkat Cells; Killer Cells, Natural; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Receptors, Fibronectin; Receptors, Lymphocyte Homing; Tyrosine | 1997 |
Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation.
Topics: Animals; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Models, Biological; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Tyrosine | 1997 |
The major myristoylated PKC substrate (MARCKS) is involved in cell spreading, tyrosine phosphorylation of paxillin, and focal contact formation.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cell Size; Choroid Neoplasms; Cytoskeletal Proteins; Humans; Intracellular Signaling Peptides and Proteins; Melanoma; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Paxillin; Phosphoproteins; Phosphorylation; Proteins; Transfection; Tumor Cells, Cultured; Tyrosine; Vinculin | 1997 |
Cell density modulates protein-tyrosine phosphorylation.
Topics: 3T3 Cells; Animals; Cell Adhesion Molecules; Cell Communication; Cell Division; Cell Movement; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Mice, Inbred BALB C; Paxillin; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Tyrosine | 1998 |
Cytoskeletal and phosphoinositide requirements for muscarinic receptor signaling to focal adhesion kinase and paxillin.
Topics: Actins; Androstadienes; Cell Adhesion; Cell Adhesion Molecules; Chromones; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Humans; Lovastatin; Morpholines; Muscarinic Agonists; Neuroblastoma; Nucleic Acid Synthesis Inhibitors; Paxillin; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Muscarinic; Second Messenger Systems; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
Relationship between paxillin and myosin phosphorylation during muscarinic stimulation of smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Dogs; Muscle, Smooth; Myosin Light Chains; Paxillin; Phosphoproteins; Phosphorylation; Tyrosine | 1998 |
Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription.
Topics: Animals; Cell Adhesion Molecules; CHO Cells; Cricetinae; Cytoskeletal Proteins; DNA-Binding Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Janus Kinase 2; Milk Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Tyrosine | 1998 |
Leishmania amazonensis: the phagocytosis of amastigotes by macrophages.
Topics: Actins; Animals; Antimetabolites; Blotting, Western; Cytochalasin B; Cytoskeletal Proteins; Deoxyglucose; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Genistein; Humans; Leishmania mexicana; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Paxillin; Phagocytosis; Phosphoproteins; Phosphorylation; Talin; Tyrosine | 1998 |
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Movement; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; GRB2 Adaptor Protein; Integrins; Mice; Mitogen-Activated Protein Kinase 1; Models, Biological; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); Receptors, Fibronectin; Retinoblastoma-Like Protein p130; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1998 |
Syk activation is required for spreading and H2O2 release in adherent human neutrophils.
Topics: Cell Adhesion Molecules; Cytoskeletal Proteins; Enzyme Activation; Enzyme Precursors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Stilbenes; Syk Kinase; Tyrosine | 1998 |
Hormonal regulation of focal adhesions in bovine adrenocortical cells: induction of paxillin dephosphorylation by adrenocorticotropic hormone.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cattle; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Colforsin; CSK Tyrosine-Protein Kinase; Cyclic AMP; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Immunohistochemistry; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine; Vanadates | 1998 |
Injury of stromal fibroblasts induces phosphorylation of focal adhesion proteins.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Corneal Stroma; Cortactin; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Fluorescent Antibody Technique, Indirect; Focal Adhesion Protein-Tyrosine Kinases; Microfilament Proteins; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rabbits; Tyrosine; Wound Healing | 1998 |
Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 2; Gene Products, tat; HIV-1; Humans; Oligopeptides; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retinoblastoma-Like Protein p130; Sarcoma, Kaposi; tat Gene Products, Human Immunodeficiency Virus; Tumor Cells, Cultured; Tyrosine | 1998 |
Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Tyrosine | 1998 |
The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Adhesion Molecules; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Paxillin; Phosphoproteins; Phosphorylation; Plasminogen Activators; Protein-Tyrosine Kinases; Proteins; Pyrazoles; Pyrimidines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Retinoblastoma-Like Protein p130; src-Family Kinases; Tyrosine; Urokinase-Type Plasminogen Activator | 1998 |
Microinjection of protein tyrosine phosphatases into fibroblasts disrupts focal adhesions and stress fibers.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Microinjections; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; rho GTP-Binding Proteins; Stress, Mechanical; Tyrosine | 1998 |
Identification of putative cytoskeletal protein homologues in the protozoan host Hartmannella vermiformis as substrates for induced tyrosine phosphatase activity upon attachment to the Legionnaires' disease bacterium, Legionella pneumophila.
Topics: Actins; Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Detergents; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hartmannella; Humans; Legionella pneumophila; Legionnaires' Disease; Octoxynol; Paxillin; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Substrate Specificity; Tyrosine; Vinculin | 1998 |
Are tyrosine phosphorylation of p125(FAK) and paxillin or the small GTP binding protein, rho, needed for CCK-stimulated pancreatic amylase secretion?
Topics: ADP Ribose Transferases; Amylases; Animals; Botulinum Toxins; Cell Adhesion Molecules; Cells, Cultured; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; GTP-Binding Proteins; Male; Pancreas; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction; Sincalide; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex.
Topics: 3T3 Cells; Actins; Androstadienes; Animals; Cell Adhesion Molecules; Chromones; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Wortmannin | 1998 |
Assay and purification and focal adhesion kinase.
Topics: Animals; Antibodies; Baculoviridae; Blotting, Western; Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Recombinant Proteins; Tyrosine | 1998 |
Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.
Topics: Amino Acid Sequence; Animals; Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; DNA-Binding Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Substrate Specificity; Tyrosine | 1998 |
Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK).
Topics: Antigens, CD; Antigens, Surface; CD146 Antigen; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Membrane Glycoproteins; Neural Cell Adhesion Molecules; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Tyrosine | 1998 |
Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis.
Topics: Antigens, CD34; Bone Marrow Cells; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chemokine CXCL12; Chemokines, CXC; Chemotaxis, Leukocyte; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 2; Hematopoietic Stem Cells; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Stem Cell Factor; Tyrosine | 1998 |
Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B.
Topics: Animals; Catalysis; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; L Cells; Lysophospholipids; Mice; Mutagenesis; Paxillin; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Subcellular Fractions; Tyrosine | 1998 |
ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Line, Transformed; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP Phosphohydrolases; GTP-Binding Proteins; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Microcirculation; Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Rats; Retinoblastoma-Like Protein p130; rho GTP-Binding Proteins; Signal Transduction; Tyrosine | 1998 |
Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Activation; Growth Hormone; Humans; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Microfilament Proteins; Mitogen-Activated Protein Kinases; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-fyn; Rats; Recombinant Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tensins; Tyrosine | 1998 |
Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins.
Topics: Animals; Antigens, CD; Apoptosis; beta Catenin; Biological Transport; Cadherins; Caspase Inhibitors; Caspases; Cattle; Cell Adhesion Molecules; Cytoskeletal Proteins; Desmoplakins; Dose-Response Relationship, Drug; Endothelium, Vascular; Focal Adhesion Protein-Tyrosine Kinases; gamma Catenin; Intercellular Junctions; Lipopolysaccharides; Models, Biological; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Serum Albumin, Bovine; Signal Transduction; Trans-Activators; Tyrosine | 1998 |
Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A.
Topics: Adenocarcinoma; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; Cyclosporine; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosuppressive Agents; Indole Alkaloids; Indoles; Integrins; Neoplasm Metastasis; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Sulfonamides; Tacrolimus; Tumor Cells, Cultured; Tyrosine | 1998 |
Decreased tyrosine phosphorylation of focal adhesion kinase after estradiol treatment of MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Dimethyl Sulfoxide; Estradiol; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Tyrosine | 1998 |
Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle.
Topics: Acetylcholine; Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Dogs; Focal Adhesion Protein-Tyrosine Kinases; In Vitro Techniques; Isometric Contraction; Mechanoreceptors; Muscle Contraction; Muscle, Smooth; Paxillin; Phosphoproteins; Phosphorylation; Potassium Chloride; Protein-Tyrosine Kinases; Reference Values; Trachea; Tyrosine | 1999 |
Adenovirus-mediated overexpression of C-terminal Src kinase (Csk) in type I astrocytes interferes with cell spreading and attachment to fibronectin. Correlation with tyrosine phosphorylations of paxillin and FAK.
Topics: Adenoviridae; Animals; Astrocytes; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Mice, Inbred ICR; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine | 1999 |
Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Adhesion Molecules; Cytoskeletal Proteins; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Retinoic Acid; Signal Transduction; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1999 |
EGF stimulates tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on phosphatidylinositol 3-kinase, the small GTP-binding protein, p21rho, and the integrit
Topics: Actins; Animals; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; In Vitro Techniques; Kinetics; Male; Pancreas; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Type C Phospholipases; Tyrosine | 1999 |
Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cell Movement; Chemotaxis; Collagen; Cytoskeletal Proteins; Drug Combinations; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gelatinases; Humans; Laminin; Lysophospholipids; Matrix Metalloproteinase 2; Metalloendopeptidases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Sphingosine; Tumor Cells, Cultured; Tyrosine | 1999 |
Integrins and the cytoskeleton: focal adhesion kinase and paxillin.
Topics: Animals; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerular Mesangium; Integrins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Stress, Mechanical; Tyrosine | 1999 |
Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase.
Topics: Actins; ADP Ribose Transferases; Botulinum Toxins; Cell Adhesion Molecules; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Cytoskeleton; Drosophila Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; GTP-Binding Proteins; Humans; Intracellular Fluid; Nerve Growth Factors; Nerve Tissue Proteins; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Retinoblastoma-Like Protein p130; rho GTP-Binding Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1999 |
Integrin-dependent tyrosine phosphorylation and growth regulation by Vav.
Topics: Actins; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Division; CHO Cells; Cricetinae; Cytoskeletal Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Jurkat Cells; Kinetics; Oncogene Proteins; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-vav; Time Factors; Transfection; Tyrosine | 1999 |
Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases.
Topics: Alprostadil; Animals; Blotting, Western; Cytoskeletal Proteins; Enzyme Inhibitors; Genistein; Neurites; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Precipitin Tests; Prostaglandins E, Synthetic; Protein-Tyrosine Kinases; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Recombinant Proteins; Signal Transduction; Tyrosine; Tyrphostins | 1999 |
Dibutyryl cyclic AMP-induced process formation in astrocytes is associated with a decrease in tyrosine phosphorylation of focal adhesion kinase and paxillin.
Topics: Actins; Animals; Astrocytes; Bucladesine; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tyrosine; Vinculin | 1999 |
Inhibition of focal contact formation in cells transformed by p185neu.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, erbB-2; Integrins; Mice; Paxillin; Phosphoproteins; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine | 1999 |
Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells.
Topics: Actins; Animals; Calcium; Cattle; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Drug Resistance; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Hydrogen Peroxide; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pulmonary Artery; Tyrosine | 1999 |
TNF-alpha induces actin cytoskeleton reorganization in glomerular epithelial cells involving tyrosine phosphorylation of paxillin and focal adhesion kinase.
Topics: Actins; Animals; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kidney Glomerulus; Paxillin; Phosphoproteins; Phosphorylation; Polymers; Protein-Tyrosine Kinases; Rats; rhoB GTP-Binding Protein; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.
Topics: Androstadienes; Cell Adhesion; Cell Size; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 2; Humans; Integrins; Neutrophil Activation; Neutrophils; Nitriles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins; Wortmannin | 1999 |
Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation.
Topics: Animals; Catalytic Domain; Cell Adhesion; Cell Adhesion Molecules; Chick Embryo; Cytoskeletal Proteins; Extracellular Matrix; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Tyrosine; Vinculin | 1999 |
Enhanced expression of the cytoskeleton-associated proteins paxillin and focal adhesion kinase in glomerular immune injury.
Topics: Animals; Anti-Glomerular Basement Membrane Disease; Antibodies; Autoantibodies; Basement Membrane; Blotting, Western; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Immunization; Immunoglobulin G; Kidney Glomerulus; Male; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rabbits; Rats; Rats, Inbred Lew; Tyrosine | 1999 |
[Differential tyrosine phosphorylation of paxillin in human corneal epithelial cells on extracellular matrix proteins].
Topics: Cells, Cultured; Collagen; Cytoskeletal Proteins; Epithelium, Corneal; Fibronectins; Humans; Laminin; Paxillin; Phosphoproteins; Phosphorylation; Tyrosine | 1999 |
RhoA inactivation enhances endothelial barrier function.
Topics: Actins; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; beta Catenin; Biological Transport; Botulinum Toxins; Cattle; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Fluorescent Antibody Technique; Hemostatics; Image Processing, Computer-Assisted; Intercellular Junctions; Myosins; Paxillin; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pulmonary Artery; rhoA GTP-Binding Protein; Stress, Mechanical; Thrombin; Trans-Activators; Tyrosine | 1999 |
Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin.
Topics: Animals; Cell Adhesion; Cell Size; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Fibroblasts; Fibronectins; Isoenzymes; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Rats; Type C Phospholipases; Tyrosine | 1999 |
The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Signal Transduction; Tyrosine | 1999 |
Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses.
Topics: Animals; Antigens, CD; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; CHO Cells; Cricetinae; Cytoskeletal Proteins; DNA-Binding Proteins; Humans; Integrin alpha4; Intracellular Signaling Peptides and Proteins; Jurkat Cells; LIM Domain Proteins; Mice; Molecular Mimicry; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Recombinant Fusion Proteins; Transcription Factors; Tyrosine | 1999 |
Expression of integrin subunit beta1B in integrin beta1-deficient GD25 cells does not interfere with alphaVbeta3 functions.
Topics: Actins; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cell Line; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Epitopes, B-Lymphocyte; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Integrin beta1; Manganese; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Rabbits; Receptors, Vitronectin; Retinoblastoma-Like Protein p130; Tyrosine; Vitronectin | 2000 |
Clustering of cell surface (beta)1,4-galactosyltransferase I induces transient tyrosine phosphorylation of focal adhesion kinase and loss of stress fibers.
Topics: 3T3 Cells; Acetylglucosamine; Animals; Cell Adhesion Molecules; Cell Membrane; Cytoskeletal Proteins; Cytoskeleton; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Galactosyltransferases; Laminin; Mice; Paxillin; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 2000 |
Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant.
Topics: Animals; Cell Adhesion; Cell Movement; CHO Cells; Cricetinae; Cytoskeletal Proteins; Cytoskeleton; Insulin; Integrins; Intracellular Signaling Peptides and Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Rats; Tyrosine | 2000 |
Tyrosine phosphorylation of focal adhesion kinase and paxillin regulates the signaling mechanism of the rapid nongenomic action of dexamethasone on actin cytoskeleton.
Topics: Actins; Cell Adhesion Molecules; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Cytosol; Dexamethasone; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Polymers; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; rhoB GTP-Binding Protein; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine | 1999 |
Lipopolysaccharide induces actin reorganization and tyrosine phosphorylation of Pyk2 and paxillin in monocytes and macrophages.
Topics: Actins; Animals; Cell Line; Cell Movement; Chromones; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 2; Humans; Lipopolysaccharides; Macrophages; Mice; Monocytes; Morpholines; Paxillin; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; src-Family Kinases; Tyrosine | 2000 |
Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Clone Cells; Collagen; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mutagenesis, Site-Directed; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Rats; src Homology Domains; Tumor Cells, Cultured; Tyrosine; Urinary Bladder Neoplasms | 2000 |
A role for phosphoinositides in tyrosine phosphorylation of p125 focal adhesion kinase in rat pancreatic acini.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Cell Adhesion Molecules; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Male; Pancreas; Paxillin; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Rats; Rats, Wistar; Retinoblastoma-Like Protein p130; Sincalide; Tyrosine | 2000 |
Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor.
Topics: 3T3 Cells; Actins; Animals; Bombesin; Butadienes; Cell Adhesion Molecules; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Paxillin; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine | 2000 |
Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C.
Topics: Animals; Cell Line; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 2; Growth Substances; Hematopoietic Stem Cells; Humans; Mice; Mice, Knockout; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Receptors, CXCR4; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine | 2000 |
Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation.
Topics: Actins; Animals; Calcium; Carrier Proteins; Cell Adhesion; Cell Differentiation; Cell Membrane; Culture Media, Serum-Free; Cytoplasm; Cytoskeletal Proteins; Cytoskeleton; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Isoenzymes; Membrane Proteins; Models, Biological; Nerve Growth Factor; Neurons; Paxillin; PC12 Cells; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor, trkA; Time Factors; Transfection; Type C Phospholipases; Tyrosine | 2000 |
Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase.
Topics: Adenoviridae; Animals; Calcium Channel Blockers; Cardiomegaly; Cell Adhesion; Cells, Cultured; Cytoskeletal Proteins; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Heart; Myocardium; Myosin Heavy Chains; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 2000 |
Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells.
Topics: Animals; Animals, Newborn; Antibodies; Axons; Cell Communication; Cell Differentiation; Cells, Cultured; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrin beta1; Neurons, Afferent; Nucleic Acid Synthesis Inhibitors; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Schwann Cells; Signal Transduction; Tyrosine | 2000 |
Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion.
Topics: Angiopoietin-1; Animals; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Fibrinolysin; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Matrix Metalloproteinases; Membrane Glycoproteins; Neoplasm Proteins; Paxillin; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pulmonary Artery; Receptor, TIE-2; Swine; Tyrosine | 2000 |
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
Topics: Actins; Cell Line; Cell Movement; Cytoskeletal Proteins; Fluorescent Antibody Technique, Indirect; Focal Adhesion Protein-Tyrosine Kinases; Green Fluorescent Proteins; Luminescent Proteins; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Recombinant Fusion Proteins; Retinoblastoma-Like Protein p130; Tyrosine | 2000 |
Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis.
Topics: Animals; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, abl; Humans; Kidney; Mice; Mice, Knockout; Morphogenesis; Mutagenesis, Site-Directed; Nerve Growth Factor; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Point Mutation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-crk; Rats; Recombinant Proteins; Transfection; Tyrosine | 2000 |
Human caco-2 motility redistributes FAK and paxillin and activates p38 MAPK in a matrix-dependent manner.
Topics: Caco-2 Cells; Cell Differentiation; Cell Division; Cell Membrane; Cell Movement; Cytoskeletal Proteins; Cytoskeleton; Cytosol; Enzyme Activation; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrointestinal Motility; Humans; Intestinal Mucosa; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paxillin; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Subcellular Fractions; Tyrosine | 2000 |
The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation.
Topics: Amino Acid Substitution; Crk-Associated Substrate Protein; Cytoplasm; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Integrin beta1; Microfilament Proteins; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; src-Family Kinases; Tensins; Tyrosine | 2000 |
ROCK mediates thrombin's endothelial barrier dysfunction.
Topics: Actins; Amides; Animals; Capillary Permeability; Cattle; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; Myosin Light Chains; Myosins; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; rho-Associated Kinases; Thrombin; Tissue Adhesions; Tyrosine | 2000 |
Calcium signaling induced by adhesion mediates protein tyrosine phosphorylation and is independent of pHi.
Topics: Animals; Calcium Signaling; Cell Adhesion; Cytoskeletal Proteins; Epithelium, Corneal; Focal Adhesion Protein-Tyrosine Kinases; Hydrogen-Ion Concentration; In Vitro Techniques; Integrins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Rabbits; Tyrosine | 2000 |
Role of Rho in Ca(2+)-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle.
Topics: ADP Ribose Transferases; Animals; Botulinum Toxins; Clostridium botulinum; Cytochalasin D; Cytoskeletal Proteins; Dogs; Muscle Contraction; Muscle, Smooth; Nucleic Acid Synthesis Inhibitors; Paxillin; Phosphoproteins; Phosphorylation; rho GTP-Binding Proteins; Signal Transduction; Trachea; Tyrosine | 2000 |
Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation.
Topics: Animals; Cell Division; Cell Line; Cell Movement; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Paxillin; Phosphoproteins; Phosphorylation; Proteins; Rats; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine | 2000 |
Nitric oxide stimulates tyrosine phosphorylation of p125(FAK) and paxillin in rat pancreatic acini.
Topics: Animals; Cyclic GMP; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pancreas; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Tyrosine | 2000 |
Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.
Topics: Actins; Adult; Cell Adhesion; Cytoskeletal Proteins; DNA-Binding Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Human Growth Hormone; Humans; Janus Kinase 2; Neutrophils; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation.
Topics: Actins; Adaptor Proteins, Signal Transducing; Calcitonin; Cell Adhesion; Cells, Cultured; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Integrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine | 2000 |
Signal transduction in the protozoan host Hartmannella vermiformis upon attachment to Legionella pneumophila.
Topics: Actin Cytoskeleton; Animals; Cytochalasin D; Cytoskeletal Proteins; Hartmannella; Lectins; Legionella pneumophila; Ligands; Paxillin; Phosphoproteins; Phosphorylation; Receptors, Mitogen; Signal Transduction; Tyrosine | 2000 |
Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase.
Topics: Actins; Amides; Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cytoskeletal Proteins; Drug Interactions; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; rho-Associated Kinases; Tumor Cells, Cultured; Tyrosine | 2000 |
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cyclic AMP-Dependent Protein Kinases; Cytochalasin D; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p21-Activated Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 2000 |
Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells.
Topics: Adenosine Triphosphatases; Animals; Antigens, CD; Antigens, Differentiation; Binding Sites; Carcinoembryonic Antigen; Cell Adhesion Molecules; Cell Extracts; Cytoplasm; Cytoskeletal Proteins; Endothelium, Vascular; Epithelial Cells; Glycoproteins; Granulocytes; HT29 Cells; Humans; Mice; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Tyrosine | 2000 |
Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components.
Topics: Androstadienes; Angiotensin II; Animals; Animals, Newborn; Astrocytes; Bradykinin; Bucladesine; Cerebral Cortex; Chelating Agents; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Paxillin; Pertussis Toxin; Phosphoproteins; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Endothelin; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases.
Topics: Actins; Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Benzoquinones; Cell Line; Cell Line, Transformed; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Fibroblasts; Focal Adhesions; Lactams, Macrocyclic; Mice; Microscopy, Fluorescence; Microtubules; Nocodazole; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Phosphatase 2; Quinones; Rifabutin; src-Family Kinases; Stress Fibers; Tyrosine; Vimentin | 2000 |
Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2.
Topics: Actins; Adenoviridae; Animals; Apoptosis; Bone and Bones; Bone Resorption; Cell Adhesion; Cell Movement; Cells, Cultured; Coculture Techniques; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 2; Mice; Microscopy, Fluorescence; Oligonucleotides, Antisense; Osteoclasts; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); Receptors, Vitronectin; Retinoblastoma-Like Protein p130; Signal Transduction; Time Factors; Tyrosine | 2001 |
Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts.
Topics: Animals; Bone Matrix; Bone Resorption; Cell Adhesion; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Focal Adhesion Kinase 2; Mice; Mice, Knockout; Osteoclasts; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptors, Vitronectin; src-Family Kinases; Tyrosine; Tyrphostins | 2001 |
Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bombesin; Carcinoma, Non-Small-Cell Lung; Cell Division; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrin-Releasing Peptide; Genistein; Humans; Lung Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 2001 |
Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis.
Topics: Adenosine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cattle; Crk-Associated Substrate Protein; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Endothelium, Vascular; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Homocysteine; Hydrolysis; Paxillin; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Tyrosine; Vanadates; Vinculin | 2001 |
Involvement of alpha5beta1 integrins in interleukin 8 production induced by oral viridans streptococcal protein I/IIf in cultured endothelial cells.
Topics: Adhesins, Bacterial; Animals; Apigenin; Bacterial Proteins; Benzoquinones; Cells, Cultured; CHO Cells; Cricetinae; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Guanosine Diphosphate; Humans; Immunoblotting; Integrins; Interleukin-8; Isoenzymes; Lactams, Macrocyclic; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Quinones; Receptors, Vitronectin; Rifabutin; Streptococcus mutans; Thionucleotides; Type C Phospholipases; Tyrosine | 1999 |
Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages.
Topics: Blotting, Western; Brain; Catalytic Domain; Cell Adhesion; Cell Division; Cell Line; Cell Movement; Cell Survival; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kidney; Macrophage Colony-Stimulating Factor; Macrophages; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Models, Biological; Mutagenesis, Site-Directed; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Time Factors; Tyrosine; Wound Healing | 2001 |
Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2.
Topics: Blood Platelets; Cytoskeletal Proteins; Cytoskeleton; DNA-Binding Proteins; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Paxillin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein-Tyrosine Kinases; Tyrosine | 2001 |
Monocyte chemoattractant protein 1 causes differential signalling mediated by proline-rich tyrosine kinase 2 in THP-1 cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Chemokine CCL2; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 2; GRB2 Adaptor Protein; Humans; Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 2001 |
Identification of a novel interaction between integrin beta1 and 14-3-3beta.
Topics: 14-3-3 Proteins; 3T3 Cells; Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; COS Cells; Cricetinae; Crk-Associated Substrate Protein; Cytoplasm; Cytoskeletal Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Mice; Molecular Sequence Data; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Polylysine; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Two-Hybrid System Techniques; Tyrosine; Tyrosine 3-Monooxygenase | 2001 |
Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells.
Topics: Angiotensin II; Animals; Binding, Competitive; Calcium; Cyclic AMP; Cyclic GMP; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Focal Adhesion Protein-Tyrosine Kinases; Iodine Radioisotopes; Kidney Tubules, Proximal; LLC-PK1 Cells; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Renin-Angiotensin System; Signal Transduction; Swine; Thymidine; Tritium; Tyrosine | 2001 |
Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins.
Topics: Actinin; Animals; Antibodies, Monoclonal; Binding Sites; Calcium Channels, L-Type; Cell Adhesion; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Ligands; Male; Microscopy, Fluorescence; Myocardium; Patch-Clamp Techniques; Paxillin; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Fibronectin; Signal Transduction; Stilbenes; Time Factors; Tyrosine; Vinculin | 2001 |
Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites; Cell Adhesion; Cell Differentiation; Cell Movement; Crk-Associated Substrate Protein; Cytoplasm; Cytoskeletal Proteins; Enzyme Activation; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine | 2001 |
The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant.
Topics: Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Extracellular Matrix; Fluorescent Antibody Technique; Hepatocyte Growth Factor; Humans; Male; Mitogens; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Prostatic Neoplasms; Tumor Cells, Cultured; Tyrosine | 2001 |
Selected contribution: roles of focal adhesion kinase and paxillin in the mechanosensitive regulation of myosin phosphorylation in smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Cell Membrane Permeability; Cytoskeletal Proteins; Cytoskeleton; Dogs; Focal Adhesion Protein-Tyrosine Kinases; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Trachea; Type C Phospholipases; Tyrosine; Vasodilator Agents | 2001 |
Platelet-derived growth factor inhibits smooth muscle cell adhesion to fibronectin by ERK-dependent and ERK-independent pathways.
Topics: Animals; Aorta; Cell Adhesion; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Flavonoids; Immunoblotting; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Muscle, Smooth; Oligonucleotides, Antisense; Oligopeptides; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Precipitin Tests; src-Family Kinases; Swine; Time Factors; Tyrosine | 2001 |
A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Size; Cells, Cultured; Cerebellum; Cytoskeletal Proteins; Dopamine; Focal Adhesion Kinase 2; Gene Expression; Glutamic Acid; Humans; Neurons; Oncogene Protein pp60(v-src); Paxillin; PC12 Cells; Phalloidine; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Wistar; src-Family Kinases; Thiazoles; Thiazolidines; Tyrosine | 2001 |
Src family kinase involvement in muscarinic receptor-induced tyrosine phosphorylation in differentiated SH-SY5Y cells.
Topics: Carbachol; Cell Differentiation; Cellular Apoptosis Susceptibility Protein; Cholinergic Agonists; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Neurons; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Receptors, Muscarinic; Signal Transduction; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 2001 |
The microtubule cytoskeleton participates in control of beta2 integrin avidity.
Topics: Animals; Antineoplastic Agents; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Line; Cell Line, Transformed; Colchicine; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Gout Suppressants; Humans; Integrins; Macrophages; Mice; Microscopy, Video; Microtubules; Models, Statistical; Nocodazole; Paclitaxel; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 2001 |
Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells.
Topics: Blotting, Western; Cell Movement; Cells, Cultured; Cornea; Cytoskeletal Proteins; Drosophila Proteins; Enzyme Inhibitors; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Nerve Tissue Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrosine | 2001 |
Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases.
Topics: Actins; Animals; beta Catenin; Blotting, Western; Cadherins; Cell Adhesion; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Epithelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lens, Crystalline; Lovastatin; Paxillin; Phosphoproteins; Phosphorylation; Protein Prenylation; rac GTP-Binding Proteins; rho GTP-Binding Proteins; Swine; Trans-Activators; Tyrosine; Vinculin | 2001 |
Podosomes in osteoclast-like cells: structural analysis and cooperative roles of paxillin, proline-rich tyrosine kinase 2 (Pyk2) and integrin alphaVbeta3.
Topics: Actins; Amino Acid Sequence; Animals; Carrier Proteins; Cell Adhesion; Cells, Cultured; Chickens; Cytoskeletal Proteins; Cytoskeleton; Fluorescent Antibody Technique; Focal Adhesion Kinase 2; Macrophages; Membrane Glycoproteins; Molecular Sequence Data; Monocytes; Osteoclasts; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Vitronectin; Tyrosine | 2001 |
Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; rac GTP-Binding Proteins; ras Proteins; Rats; rhoA GTP-Binding Protein; Sphingomyelin Phosphodiesterase; Sphingosine; Stress Fibers; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin.
Topics: Animals; Binding Sites; Cell Adhesion; Chick Embryo; Culture Media, Serum-Free; Cytoskeletal Proteins; DNA, Complementary; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Signal Transduction; src Homology Domains; Tyrosine | 2001 |
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
Topics: Amiloride; Animals; Blotting, Western; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibronectins; Immunoblotting; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pseudopodia; Rats; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine | 2002 |
Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association.
Topics: Animals; Butadienes; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Escherichia coli; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Hepatocyte Growth Factor; Kidney Tubules; MAP Kinase Signaling System; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nitriles; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Serine; Threonine; Time Factors; Tyrosine | 2002 |
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.
Topics: Animals; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Embryonic and Fetal Development; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gene Expression Regulation, Developmental; Gene Targeting; Mesoderm; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Fibronectin; Signal Transduction; Tyrosine | 2002 |
FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation.
Topics: Animals; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Mice; Oncogene Protein pp60(v-src); Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine | 2002 |
HIV-1 down-modulates gamma signaling chain of Fc gamma R in human macrophages: a possible mechanism for inhibition of phagocytosis.
Topics: Cells, Cultured; Cyclic AMP; Cytoskeletal Proteins; Down-Regulation; Enzyme Precursors; HIV Infections; HIV-1; Humans; Intracellular Signaling Peptides and Proteins; Macrophages; Monocytes; Paxillin; Phagocytosis; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Receptors, IgG; Signal Transduction; Syk Kinase; Tyrosine | 2002 |
Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Molecular Sequence Data; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Tyrosine | 2002 |
The structural basis of localization and signaling by the focal adhesion targeting domain.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Crystallography, X-Ray; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; Humans; Models, Molecular; Molecular Sequence Data; Paxillin; Phosphoproteins; Protein Structure, Secondary; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proteins; Sequence Alignment; Signal Transduction; src Homology Domains; Tyrosine | 2002 |
Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actin-dependent manner.
Topics: Actins; Biological Transport; Cytoskeletal Proteins; Endothelium, Vascular; Fibroblast Growth Factor 2; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Histocompatibility Antigens Class I; Humans; Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; src-Family Kinases; Tyrosine | 2002 |
Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration.
Topics: Blotting, Western; Breast Neoplasms; Cell Movement; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Down-Regulation; Female; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Megakaryocytes; Neoplasm Invasiveness; Neuregulin-1; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, ErbB-2; Recombinant Proteins; Signal Transduction; src-Family Kinases; Transfection; Tumor Cells, Cultured; Tyrosine | 2002 |
Dynamitin controls Beta 2 integrin avidity by modulating cytoskeletal constraint on integrin molecules.
Topics: Animals; Calmodulin-Binding Proteins; CD18 Antigens; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Dynactin Complex; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Integrins; Intracellular Signaling Peptides and Proteins; Ligands; Luminescent Proteins; Membrane Proteins; Mice; Microfilament Proteins; Microscopy, Fluorescence; Microscopy, Video; Microtubule-Associated Proteins; Microtubules; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Recombinant Fusion Proteins; rhoA GTP-Binding Protein; Staurosporine; Time Factors; Transfection; Tyrosine | 2002 |
EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).
Topics: 3T3 Cells; Actins; Animals; Cell Adhesion; Cell Line; Cell Movement; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Cytoskeleton; Ephrin-A1; Ephrin-A2; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Mice, Knockout; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptor Protein-Tyrosine Kinases; Receptor, EphA2; Retinoblastoma-Like Protein p130; Signal Transduction; Transcription Factors; Tyrosine | 2002 |
Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.
Topics: Amino Acid Motifs; Animals; Cell Adhesion; Cell Membrane; Cell Movement; Cell Surface Extensions; Chlorocebus aethiops; COS Cells; Cytoskeletal Proteins; Fibronectins; Guanine Nucleotide-Releasing Factor 2; Guanosine Triphosphate; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinases; p21-Activated Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Transport; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; rac GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Tyrosine | 2002 |
The signaling protein Rho is necessary for vascular smooth muscle migration and survival but not for proliferation.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Apoptosis; Blotting, Western; Botulinum Toxins; Cell Division; Cell Movement; Cell Survival; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Microfilament Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; rho GTP-Binding Proteins; Tensins; Tyrosine | 2002 |
Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho.
Topics: Alendronate; Cell Movement; Cell Survival; Cytoskeletal Proteins; Diterpenes; Drug Interactions; Enzyme Activation; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lysophospholipids; Myosin Light Chains; Ovarian Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Tumor Cells, Cultured; Tyrosine | 2002 |
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.
Topics: Cell Adhesion; Cell Membrane; Cell Movement; Cytoskeletal Proteins; Focal Adhesions; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Immunohistochemistry; Mutation; Nuclear Proteins; p120 GTPase Activating Protein; Paxillin; Peptides; Phenotype; Phosphoproteins; Phosphorylation; Protein Binding; Recombinant Fusion Proteins; Repressor Proteins; rhoA GTP-Binding Protein; RNA, Small Interfering; src Homology Domains; Tyrosine | 2002 |
Lysophosphatidic acid induces focal adhesion assembly through Rho/Rho-associated kinase pathway in human ovarian cancer cells.
Topics: Cell Movement; Cytoskeletal Proteins; Enzyme Inhibitors; Female; Focal Adhesions; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Ovarian Neoplasms; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Stress Fibers; Tumor Cells, Cultured; Tyrosine | 2002 |
High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium.
Topics: Animals; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesions; In Vitro Techniques; Inflammation; Inflammation Mediators; Lung; P-Selectin; Paxillin; Perfusion; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Tidal Volume; Tyrosine | 2003 |
Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Bradykinin; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Stress Fibers; Tyrosine; Tyrphostins; Vasoconstrictor Agents; Vasopressins | 2003 |
Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption.
Topics: Amino Acid Sequence; Antineoplastic Agents; Cell Line; Cytological Techniques; Cytoskeletal Proteins; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Genes, Reporter; Microtubules; Molecular Sequence Data; Nocodazole; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); src Homology Domains; Tyrosine; Vinculin | 2003 |
Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation; COS Cells; Cytoskeletal Proteins; Drosophila Proteins; Focal Adhesion Kinase 2; Interleukin-1 Receptor-Associated Kinases; Lipopeptides; Macrophages; Membrane Glycoproteins; Myeloid Differentiation Factor 88; Oligopeptides; Paxillin; Phosphoproteins; Protein Kinases; Protein-Tyrosine Kinases; Pyrimidines; Rats; Receptors, Cell Surface; Receptors, Immunologic; src-Family Kinases; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Tyrosine | 2003 |
Transmodulation between phospholipase D and c-Src enhances cell proliferation.
Topics: Animals; Carcinoma, Squamous Cell; Catalytic Domain; Cell Division; Cells, Cultured; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Mutation; Paxillin; Phospholipase D; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Tyrosine | 2003 |
Nuclear translocation of Xenopus laevis paxillin.
Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apigenin; Cell Cycle; Cell Fractionation; Cell Line; Cytoskeletal Proteins; Fibronectins; Flavonoids; Integrins; Laminin; Mitogen-Activated Protein Kinases; Models, Biological; Paxillin; Phosphoproteins; Phosphorylation; Serine; Tyrosine; Vitronectin; Xenopus laevis; Xenopus Proteins | 2003 |
Heparanase mediates cell adhesion independent of its enzymatic activity.
Topics: Animals; Cell Adhesion; Cell Membrane; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Endothelium; Extracellular Matrix; Glucuronidase; Lymphoma; Mice; Neoplasm Invasiveness; Oligopeptides; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2003 |
An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells.
Topics: Adenoviridae; Angiotensin II; Animals; Aorta, Thoracic; Becaplermin; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Membrane; Cell Movement; Cells, Cultured; Cellular Apoptosis Susceptibility Protein; COS Cells; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Green Fluorescent Proteins; Immunohistochemistry; Luminescent Proteins; Mitogen-Activated Protein Kinases; Models, Biological; Muscle, Smooth; Paxillin; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; rac1 GTP-Binding Protein; Rats; Recombinant Fusion Proteins; Tetrazolium Salts; Time Factors; Transfection; Tyrosine | 2003 |
Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration.
Topics: Cell Movement; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Fibronectins; Green Fluorescent Proteins; Humans; Luminescent Proteins; Microscopy, Fluorescence; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Recombinant Proteins; Retinoblastoma-Like Protein p130; RNA, Small Interfering; Tyrosine | 2003 |
Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.
Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Mitogens; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-met; Survival Rate; Tumor Cells, Cultured; Tyrosine | 2003 |
Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase.
Topics: Adenoviridae; Blotting, Western; Brain; Cell Line; Cell Movement; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Enzyme Activation; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Genes, Dominant; Genetic Vectors; Green Fluorescent Proteins; Humans; Immunoblotting; Immunohistochemistry; Integrins; Laminin; Luminescent Proteins; Microcirculation; Microscopy, Confocal; Models, Biological; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proteins; Receptors, Vitronectin; Recombinant Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine; Vascular Endothelial Growth Factor A | 2003 |
The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cell Adhesion; Cell Differentiation; Cell Line; Cytoskeletal Proteins; Extracellular Matrix; Fibronectins; Integrin alpha5beta1; Integrins; Laminin; Mice; Molecular Sequence Data; Muscle Proteins; Myoblasts; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Signal Transduction; Tyrosine | 2003 |
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development.
Topics: Acetylcholine; Actins; Animals; Chickens; Creatine Kinase; Cytoskeletal Proteins; DNA, Complementary; Dogs; Focal Adhesion Protein-Tyrosine Kinases; Muscle Contraction; Muscle, Smooth; Mutation; Myosin Light Chains; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein-Tyrosine Kinases; Recombinant Proteins; Trachea; Tyrosine | 2003 |
Ochratoxin A affects COS cell adhesion and signaling.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Adhesion; Cell Adhesion Molecules; Cell Survival; Chlorocebus aethiops; COS Cells; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Focal Adhesion Protein-Tyrosine Kinases; Mycotoxins; Ochratoxins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 2003 |
Alterations in granule matrix and cell surface of focal adhesion kinase-deficient mast cells.
Topics: Animals; Cell Differentiation; Cell Membrane; Cells, Cultured; Cytoplasmic Granules; Cytoskeletal Proteins; Embryo, Mammalian; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycosaminoglycans; Immunoglobulin E; Integrin beta Chains; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Scanning; Microvilli; Paxillin; Phosphoproteins; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptors, IgE; Signal Transduction; Tyrosine | 2003 |
Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells.
Topics: Breast Neoplasms; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Focal Adhesion Kinase 2; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Humans; Mutation; Neuregulin-1; Nuclear Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-abl; Repressor Proteins; Retinoblastoma-Like Protein p130; Tyrosine | 2004 |
Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT.
Topics: Adaptor Proteins, Signal Transducing; Cell Cycle Proteins; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; GTPase-Activating Proteins; Humans; Lysophospholipids; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Sphingosine; Thrombin; Tyrosine | 2003 |
Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells.
Topics: Colonic Neoplasms; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Densitometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Humans; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptor, Cholecystokinin B; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured; Tyrosine | 2004 |
Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro.
Topics: Cell Line, Tumor; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Dose-Response Relationship, Radiation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; Humans; Lung Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Radiation Dosage; Radiation, Ionizing; Retinoblastoma-Like Protein p130; Tyrosine; X-Rays | 2003 |
Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins.
Topics: Actins; Blotting, Western; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Cytoskeleton; Endothelial Cells; Endothelium, Vascular; Humans; Lipid Metabolism; Lipoproteins; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; Oxygen; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphatidylcholines; Phosphoproteins; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Time Factors; Tyrosine | 2004 |
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Aorta; Cell Movement; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Glutathione Transferase; Humans; Immunoblotting; Microscopy, Fluorescence; Mutation; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; RNA, Small Interfering; Swine; Telomerase; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118.
Topics: Amino Acid Motifs; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Movement; CHO Cells; Cricetinae; Cytoskeletal Proteins; Genes, Dominant; Ligands; Mice; Models, Biological; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Receptor, EphB1; Signal Transduction; Time Factors; Transfection; Tyrosine | 2004 |
Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Carrier Proteins; CD47 Antigen; Cell Adhesion; Cell Line; Cell Movement; CHO Cells; Concanavalin A; Cricetinae; Culture Media; Cytoplasm; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Immunoblotting; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinases; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Neural Cell Adhesion Molecule L1; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; ras Proteins; Receptors, Immunologic; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Temperature; Time Factors; Tyrosine | 2004 |
Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium.
Topics: Actins; Adenosine Triphosphate; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Activators; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lysophospholipids; Osmotic Pressure; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; Tyrosine; Umbilical Veins | 2004 |
RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner.
Topics: Animals; Chromatography, Affinity; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Focal Adhesion Kinase 2; Humans; Immunosorbent Techniques; Mice; Mutagenesis, Site-Directed; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Signal Transduction; Transcriptional Activation; Transfection; Tyrosine | 2004 |
RACK1 inhibits the serum- and anchorage-independent growth of v-Src transformed cells.
Topics: Actins; Animals; Cell Adhesion; Cell Count; Cell Division; Cell Line, Transformed; Culture Media; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; NIH 3T3 Cells; Oncogene Protein pp60(v-src); Paxillin; Peptides; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptors for Activated C Kinase; Serum; Transfection; Transformation, Genetic; Tyrosine | 2004 |
Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Line; Cell Movement; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Membrane Proteins; Mice; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Point Mutation; Protein Isoforms; Protein Phosphatase 2; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Virus; Sequence Alignment; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Tyrosine | 2004 |
Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities.
Topics: Amides; Benzoquinones; CD18 Antigens; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; DNA, Complementary; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Gene Transfer Techniques; Genes, Dominant; Green Fluorescent Proteins; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Luminescent Proteins; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Pyridines; Quinones; rhoA GTP-Binding Protein; src-Family Kinases; Time Factors; Tyrosine; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-2; Vinculin | 2004 |
Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive.
Topics: Actins; Animals; B-Lymphocytes; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Genetic Vectors; Humans; Immunohistochemistry; Immunoprecipitation; Interleukin-3; Lymphocytes; Mice; Microscopy, Fluorescence; Mutation; Paxillin; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases.
Topics: 3T3 Cells; Actins; Animals; Apoptosis; Bacterial Toxins; Bombesin; cdc42 GTP-Binding Protein; Clostridioides difficile; Cytoskeletal Proteins; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP Phosphohydrolases; Immunoprecipitation; In Situ Nick-End Labeling; Kinetics; Lipids; Mice; Microscopy, Fluorescence; Mutation; Osmosis; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 2; Protein-Tyrosine Kinases; Proteins; rac1 GTP-Binding Protein; Retinoblastoma-Like Protein p130; rhoA GTP-Binding Protein; src-Family Kinases; Stress, Physiological; Sucrose; Time Factors; Transgenes; Tyrosine | 2004 |
Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Movement; Collagen; Cytoskeletal Proteins; Down-Regulation; Epithelial Cells; GTP Phosphohydrolases; Immunoprecipitation; Mutation; Paxillin; Phosphoproteins; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rats; Signal Transduction; Time Factors; Transfection; Tyrosine | 2004 |
Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity.
Topics: Actins; Cell Line, Tumor; Cyclin D1; Cytoskeletal Proteins; Extracellular Matrix Proteins; Focal Adhesions; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Integrin beta1; Lung Neoplasms; MAP Kinase Signaling System; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Retinoblastoma Protein; Subcellular Fractions; Transfection; Tyrosine | 2004 |
Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin.
Topics: Adenoviridae; Animals; Animals, Newborn; Apoptosis; Binding Sites; Caspase 3; Caspases; Cell Adhesion; Cell Cycle Proteins; Cells, Cultured; Cytoplasm; Cytoskeletal Proteins; Cytoskeleton; DNA; DNA Fragmentation; DNA, Complementary; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Focal Adhesion Kinase 2; Genes, Dominant; Immediate-Early Proteins; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Microscopy, Fluorescence; Models, Biological; Mutation; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Paxillin; Phenotype; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Staurosporine; Time Factors; Tyrosine; Vinculin | 2004 |
HLA class I signal transduction is dependent on Rho GTPase and ROK.
Topics: Actins; Cell Division; Cells, Cultured; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Histocompatibility Antigens Class I; Humans; Hybridomas; Intracellular Signaling Peptides and Proteins; Muscle, Smooth; Myocytes, Smooth Muscle; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Tyrosine | 2004 |
alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
Topics: Alleles; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; COS Cells; Cytokines; Cytoskeletal Proteins; Drosophila melanogaster; Embryo, Nonmammalian; Gene Deletion; Growth Substances; Heparin; Immunoprecipitation; Integrin alpha4beta1; Integrin alpha6beta1; Low Density Lipoprotein Receptor-Related Protein-1; Mice; Midkine; Mutation; Neurons; Paxillin; Phosphoproteins; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Time Factors; Tyrosine | 2004 |
Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.
Topics: Alanine; Amino Acid Sequence; Animals; Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Movement; CHO Cells; Cricetinae; Cytoskeletal Proteins; DNA; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Lysine; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; NIH 3T3 Cells; Paxillin; Phosphoproteins; Phosphorylation; Point Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyrimidines; Sequence Homology, Amino Acid; src-Family Kinases; Time Factors; Transfection; Tyrosine | 2005 |
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids.
Topics: Animals; Carcinoma; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Collagen; Colon; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoprecipitation; Liver; Liver Neoplasms; Male; Microcirculation; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms; Oligonucleotides; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Time Factors; Transfection; Tyrosine | 2005 |
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.
Topics: Animals; Blotting, Western; Cell Adhesion; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Humans; Immunoblotting; Immunoprecipitation; Mutation; Neoplasms; Paxillin; Peptides; Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 3; src-Family Kinases; Thyroid Gland; Thyroid Neoplasms; Transfection; Tyrosine | 2005 |
p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV.
Topics: Animals; Caco-2 Cells; Cell Movement; Collagen Type IV; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intestinal Mucosa; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); Retinoblastoma-Like Protein p130; Tyrosine | 2005 |
The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle.
Topics: Acetylcholine; Actin-Related Protein 2; Actin-Related Protein 3; Actins; Animals; Calcium; cdc42 GTP-Binding Protein; Cytoskeletal Proteins; Dogs; Gene Expression Regulation; Immunoprecipitation; Models, Biological; Muscle Contraction; Muscle, Smooth; Muscles; Mutation; Myosin Light Chains; Neurons; Oligonucleotides, Antisense; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Protein Binding; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Recombinant Proteins; Signal Transduction; src Homology Domains; Trachea; Tyrosine; Wiskott-Aldrich Syndrome Protein | 2005 |
p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase.
Topics: Animals; Cell Cycle Proteins; Cell Membrane; Cell Movement; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Immunologic Factors; Lysophospholipids; Mice; Mutation; Neuropeptides; NIH 3T3 Cells; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rho Guanine Nucleotide Exchange Factors; Transfection; Tyrosine | 2005 |
Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclic AMP; Focal Adhesion Kinase 1; Gastrins; Genes, Immediate-Early; Humans; Inositol 1,4,5-Trisphosphate; Paxillin; Phosphorylation; Point Mutation; Protein Structure, Secondary; Receptor, Cholecystokinin B; RNA, Messenger; Signal Transduction; Transfection; Tyrosine; Up-Regulation; Valine | 2005 |
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.
Topics: Animals; Binding Sites; Cell Line, Transformed; Cell Movement; Cells, Cultured; Collagen; Cytoskeletal Proteins; Drug Combinations; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Injections, Subcutaneous; Laminin; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Oncogene Protein v-crk; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Retroviridae Proteins, Oncogenic; src Homology Domains; Tyrosine | 2005 |
Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin.
Topics: Actins; Blotting, Western; Cell Count; Cell Death; Cell Line, Tumor; Cell Movement; Culture Media, Serum-Free; Disintegrins; Drug Interactions; Fibronectins; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Gene Expression; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunoprecipitation; Integrins; Paxillin; Signal Transduction; Subcellular Fractions; Time Factors; Tyrosine | 2005 |
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Line; Cell Movement; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Genes, Reporter; GTPase-Activating Proteins; Intercellular Signaling Peptides and Proteins; Mice; Oncogene Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Recombinant Fusion Proteins; src-Family Kinases; Structure-Activity Relationship; Tyrosine | 2005 |
Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.
Topics: Cell Division; Cell Line, Tumor; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Gangliosides; Humans; Melanoma; Neoplasm Invasiveness; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; RNA, Small Interfering; Sialyltransferases; Transfection; Tyrosine | 2005 |
Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.
Topics: Actins; Agar; Androstadienes; Animals; Anoikis; Binding Sites; Cell Adhesion; Cell Cycle; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Collagen; Crk-Associated Substrate Protein; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gelatin; Genes, Dominant; Immunoblotting; Immunoprecipitation; Laminin; Matrix Metalloproteinase 2; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Paxillin; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Talin; Time Factors; Transfection; Tyrosine; Vinculin; Wortmannin | 2005 |
Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation.
Topics: Actins; Animals; Chlorocebus aethiops; COS Cells; Cytoskeletal Proteins; DNA-Binding Proteins; Epidermal Growth Factor; Focal Adhesions; Humans; LIM Domain Proteins; Mice; Mutation; Paxillin; Phosphorylation; Pseudopodia; rac GTP-Binding Proteins; Tyrosine | 2005 |
RAFTK/Pyk2 mediates LPA-induced PC12 cell migration.
Topics: Animals; Calcium; Cell Movement; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Lysophospholipids; Paxillin; PC12 Cells; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Rats; Receptors, Lysophosphatidic Acid; Tyrosine | 2006 |
Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions.
Topics: Actinin; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cells, Cultured; Collagen; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Focal Adhesions; Humans; Interleukin-1; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Paxillin; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; RNA, Small Interfering; Signal Transduction; Transfection; Tyrosine; Vanadates | 2006 |
Paxillin phosphorylation sites mapped by mass spectrometry.
Topics: Animals; Cell Line; Chickens; Chromatography, High Pressure Liquid; Humans; Mice; Paxillin; Phosphorylation; Serine; Spectrometry, Mass, Electrospray Ionization; Threonine; Transfection; Tyrosine | 2005 |
CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration.
Topics: Animals; Antigens, CD; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Contractile Proteins; Cytoskeleton; Filamins; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Humans; Microfilament Proteins; Paxillin; Phosphorylation; Protein Binding; Rats; Two-Hybrid System Techniques; Tyrosine | 2005 |
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases.
Topics: Animals; Chorionic Gonadotropin; Enzyme Inhibitors; Focal Adhesion Kinase 1; GTP-Binding Proteins; Humans; Leydig Cell Tumor; Male; Mice; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Pyrimidines; Receptors, LH; Recombinant Proteins; Signal Transduction; src-Family Kinases; Testicular Neoplasms; Tumor Cells, Cultured; Tyrosine | 2006 |
Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin.
Topics: Alkaline Phosphatase; Blotting, Western; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; HT29 Cells; Humans; Immunoprecipitation; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphorylation; Serine; Signal Transduction; Threonine; Tyrosine | 2006 |
The molecular dynamics of osteoclast adhesions.
Topics: Actin Cytoskeleton; Actinin; Animals; Cell Adhesion; Immunohistochemistry; Mice; Mice, Inbred BALB C; Osteoclasts; Paxillin; Phosphorylation; Tyrosine | 2006 |
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer.
Topics: Animals; Crk-Associated Substrate Protein; Fluorescence Resonance Energy Transfer; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Mice; NIH 3T3 Cells; Paxillin; Phosphorylation; Protein Interaction Mapping; src Homology Domains; Tyrosine | 2006 |
TIMP-2 upregulates RECK expression via dephosphorylation of paxillin tyrosine residues 31 and 118.
Topics: Cells, Cultured; GPI-Linked Proteins; Humans; Membrane Glycoproteins; Paxillin; Phosphorylation; rac1 GTP-Binding Protein; rap1 GTP-Binding Proteins; Signal Transduction; src-Family Kinases; Tissue Inhibitor of Metalloproteinase-2; Tyrosine; Up-Regulation | 2006 |
Integrin-induced tyrosine phosphorylation of protein-tyrosine phosphatase-alpha is required for cytoskeletal reorganization and cell migration.
Topics: Actins; Animals; Cell Adhesion; Cell Movement; Cytoskeleton; Embryo, Mammalian; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Ligands; Mice; Mice, Knockout; Paxillin; Peptide Fragments; Phosphorylation; Protein Tyrosine Phosphatases; Rabbits; Signal Transduction; src-Family Kinases; Tyrosine | 2006 |
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Topics: Animals; Cell Movement; Cytoskeleton; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Glycogen Synthase Kinase 3; Humans; Lipopolysaccharides; Macrophages; Mice; Nerve Growth Factors; Neurites; Paxillin; PC12 Cells; Phosphorylation; Protein Transport; Rats; Serine; Tyrosine | 2006 |
Paxillin phosphorylation and integrin expression in osteoblasts infected by Porphyromonas gingivalis.
Topics: Bacterial Adhesion; Bacteroidaceae Infections; Blotting, Western; Cells, Cultured; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin alpha3; Integrin beta1; Integrins; Osteoblasts; Paxillin; Phosphorylation; Porphyromonas gingivalis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2006 |
Formation of focal adhesion-like structures in circulating human neutrophils after severe injury: triggering of a tissue-phase response in the vascular space.
Topics: Adult; Detergents; Female; Fibronectins; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Male; Middle Aged; Neutrophils; Paxillin; Phosphotyrosine; Proto-Oncogene Proteins; src-Family Kinases; Tyrosine; Wounds and Injuries | 2006 |
CpG DNA enhances macrophage cell spreading by promoting the Src-family kinase-mediated phosphorylation of paxillin.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Cell Movement; Cells, Cultured; CpG Islands; Female; Humans; Immunoprecipitation; Macrophages; Mice; Mice, Inbred C57BL; Oligonucleotides; Paxillin; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-hck; src Homology Domains; src-Family Kinases; Tyrosine | 2006 |
Selective regulation of hydrogen peroxide signaling by receptor tyrosine phosphatase-alpha.
Topics: Cells, Cultured; Crk-Associated Substrate Protein; Humans; Hydrogen Peroxide; Paxillin; Phosphorylation; Protein Tyrosine Phosphatases; Reactive Oxygen Species; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Signal Transduction; Tyrosine | 2006 |
Roles of microfilaments and microtubules in paxillin dynamics.
Topics: Actin Cytoskeleton; Animals; Cattle; Cell Movement; Cells, Cultured; Colchicine; Cytochalasin D; Endothelium, Vascular; Focal Adhesions; Microtubules; Paclitaxel; Paxillin; Phosphorylation; Tubulin Modulators; Tyrosine | 2006 |
Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding.
Topics: Animals; Axons; Blastomeres; Blotting, Western; Cell Adhesion; Cell Movement; Cells, Cultured; Embryo, Nonmammalian; Extracellular Matrix Proteins; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Green Fluorescent Proteins; Growth Cones; Integrins; Neurons; Paxillin; Phosphorylation; Signal Transduction; Spinal Cord; Time Factors; Tyrosine; Xenopus laevis | 2006 |
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.
Topics: Animals; Antibodies; Aorta; Cell Adhesion; Endothelial Cells; Extracellular Matrix; Fibroblasts; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Models, Biological; Mutagenesis; Paxillin; Phosphorylation; Pseudopodia; Rats; Stress, Mechanical; Swine; Transfection; Tyrosine | 2007 |
Stimulation of corneal epithelial migration by a synthetic peptide (PHSRN) corresponding to the second cell-binding site of fibronectin.
Topics: Actins; Animals; Cell Line, Transformed; Cell Movement; Cell Proliferation; Cell Transformation, Viral; Dose-Response Relationship, Drug; Epithelium, Corneal; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunoprecipitation; Microscopy, Fluorescence; Organ Culture Techniques; Paxillin; Peptide Fragments; Phosphorylation; Photography; Rabbits; Tyrosine; Up-Regulation; Wound Healing | 2007 |
Polymorphonuclear leukocyte transverse migration induces rapid alterations in endothelial focal contacts.
Topics: Actins; Animals; Aorta; Calcium; Calcium Signaling; Carotid Arteries; Cell Adhesion; Cell Movement; Chemotaxis, Leukocyte; Endothelium, Vascular; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Neutrophils; Paxillin; Phosphorylation; Rabbits; Rats; Tyrosine; Umbilical Veins | 2007 |
Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction.
Topics: Actin Cytoskeleton; Actins; Animals; Artifacts; Carotid Artery, Common; Histamine; Histamine Agents; In Vitro Techniques; Paxillin; Phosphorylation; Polymers; Potassium; Rheology; Stress, Mechanical; Swine; Temperature; Tyrosine; Vasoconstriction | 2007 |
Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury.
Topics: Actins; Animals; Blotting, Western; Butadienes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunohistochemistry; Kidney; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Paxillin; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Wistar; Reperfusion Injury; Stress Fibers; Talin; Time Factors; Tyrosine | 2007 |
CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.
Topics: Actins; Amyloid beta-Peptides; Animals; CD36 Antigens; Cell Movement; Crk-Associated Substrate Protein; Cytoskeleton; Focal Adhesion Kinase 2; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Microglia; Paxillin; Phosphorylation; Signal Transduction; Toll-Like Receptors; Tyrosine | 2007 |
RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3.
Topics: Amides; Animals; Benzoquinones; Cell Line; Enzyme Inhibitors; Exocytosis; Focal Adhesion Kinase 1; Hydrochloric Acid; Hydrogen-Ion Concentration; Lactams, Macrocyclic; Opossums; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; rhoA GTP-Binding Protein; Rifabutin; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Stress Fibers; Tyrosine | 2007 |
Reassessing the role of phosphocaveolin-1 in cell adhesion and migration.
Topics: Animals; Blotting, Western; Cattle; Caveolin 1; Cell Adhesion; Cell Line; Cell Movement; Immunoblotting; Microscopy, Fluorescence; Models, Biological; Paxillin; Phosphorylation; Sucrose; Tyrosine | 2007 |
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
Topics: Animals; Cell Movement; Cell Proliferation; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesions; Gene Expression Regulation; Mice; Paxillin; Phosphorylation; ras-GRF1; rhoA GTP-Binding Protein; Tyrosine | 2008 |
Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1.
Topics: Actinin; Cell Adhesion; Cell Line, Tumor; Colonic Neoplasms; Crk-Associated Substrate Protein; Humans; Neoplasm Metastasis; Paxillin; Phosphorylation; Pressure; Proto-Oncogene Proteins c-crk; rac1 GTP-Binding Protein; RNA Interference; Tumor Cells, Cultured; Tyrosine | 2008 |
FAK-independent alphavbeta3 integrin-EGFR complexes rescue from anoikis matrix-defective fibroblasts.
Topics: Actins; Anoikis; Caspases; Cell Adhesion; Cell Membrane; Cells, Cultured; Cytoskeleton; Ehlers-Danlos Syndrome; ErbB Receptors; Extracellular Matrix; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Humans; Integrin alpha5beta1; Integrin alphaVbeta3; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Skin; Talin; Tyrosine; Vinculin | 2008 |
CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunoblotting; Mice; Microscopy, Fluorescence; NIH 3T3 Cells; Paxillin; Phosphoproteins; Protein Kinase Inhibitors; Sulfonamides; Tyrosine | 2008 |
Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer.
Topics: Cell Line, Tumor; Disease Progression; ErbB Receptors; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Models, Biological; Neoplasm Invasiveness; Ovarian Neoplasms; Paxillin; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; src-Family Kinases; Tyrosine | 2008 |
FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.
Topics: Cell Line, Tumor; Cell Movement; Cells, Cultured; Chenodeoxycholic Acid; DNA-Binding Proteins; Endothelial Cells; Focal Adhesion Kinase 1; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinase 9; Mutation; Neovascularization, Physiologic; Paxillin; Phosphorylation; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation; Transfection; Tyrosine | 2009 |
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Neoplasm Invasiveness; Paxillin; Recombinant Fusion Proteins; RNA, Small Interfering; src-Family Kinases; Tyrosine | 2009 |
Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.
Topics: Animals; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; GRB7 Adaptor Protein; Humans; Integrins; Mice; NIH 3T3 Cells; Paxillin; Phosphorylation; Point Mutation; Proto-Oncogene Proteins c-akt; Tyrosine | 2009 |
LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.
Topics: Animals; Cell Adhesion Molecules; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Integrins; K562 Cells; Mice; NIH 3T3 Cells; Paxillin; Phosphoproteins; Phosphorylation; Transcription Factors; Tyrosine | 2010 |
Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney.
Topics: Animals; Binding Sites; Blotting, Western; Cell Adhesion Molecules; Electrophoresis, Gel, Two-Dimensional; Focal Adhesion Kinase 1; Immunohistochemistry; Immunoprecipitation; Kidney; Kidney Glomerulus; Male; Mass Spectrometry; Membrane Proteins; Microscopy, Immunoelectron; Paxillin; Phosphorylation; Podocytes; Proteins; Proteomics; Rats; Rats, Wistar; Receptors, Immunologic; Tyrosine | 2010 |
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Topics: Animals; Azoxymethane; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Female; HCT116 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mutation; Neoplasms, Experimental; Paxillin; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Substrate Specificity; Transfection; Transplantation, Heterologous; Tyrosine | 2010 |
Focal adhesion kinase functions downstream of Sema3A signaling during axonal remodeling.
Topics: Actinin; Animals; Axons; Brain; Cell Adhesion; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Mice; Mice, Knockout; Mice, Transgenic; Paxillin; Phosphorylation; Protein Structure, Tertiary; Semaphorin-3A; Tyrosine | 2010 |
Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers.
Topics: Animals; Caco-2 Cells; Cell Movement; Chickens; Crk-Associated Substrate Protein; Dose-Response Relationship, Drug; Enzyme Activation; Focal Adhesion Kinase 1; Humans; Hydrogen Peroxide; Intestinal Mucosa; Mice; Mutation; Oxidants; Oxidative Stress; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); RNA Interference; Signal Transduction; Time Factors; Tyrosine; Vinculin; Xanthine; Xanthine Oxidase | 2010 |
T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.
Topics: Actins; Cell Line, Tumor; Cells, Cultured; Cytoskeleton; Enzyme Activation; Focal Adhesion Kinase 2; Humans; Immunoblotting; Jurkat Cells; Kinetics; Paxillin; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, Antigen, T-Cell; src-Family Kinases; T-Lymphocytes; Time Factors; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 2010 |
The effect of lysophosphatidic acid and Rho-associated kinase patterning on adhesion of dental pulp cells.
Topics: Adult; Amides; Cell Movement; Cells, Cultured; Dental Pulp; Focal Adhesion Kinase 1; Focal Adhesions; Humans; Lysophospholipids; Paxillin; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Tyrosine; Young Adult | 2011 |
Ganglioside GD3 monoclonal antibody-induced paxillin tyrosine phosphorylation and filamentous actin assembly in cerebellar growth cones.
Topics: Actins; Animals; Animals, Newborn; Antibodies, Monoclonal; Cells, Cultured; Cerebellum; Gangliosides; Growth Cones; Neurons; Paxillin; Phosphorylation; Rats; Time Factors; Tyrosine | 2011 |
β2 integrin induces TCRζ-Syk-phospholipase C-γ phosphorylation and paxillin-dependent granule polarization in human NK cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium Signaling; CD18 Antigens; Cell Degranulation; Cell Line; Cell Polarity; Cells, Cultured; Cytoplasmic Granules; Drosophila melanogaster; GPI-Linked Proteins; Humans; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lymphocyte Activation; Membrane Proteins; Paxillin; Perforin; Phospholipase C gamma; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, IgG; Syk Kinase; Tyrosine | 2011 |
FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion.
Topics: Animals; Cell Surface Extensions; Cells, Cultured; Crk-Associated Substrate Protein; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Mice; Mice, Knockout; Paxillin; Phosphorylation; rac1 GTP-Binding Protein; Signal Transduction; Tyrosine | 2011 |
Pituitary adenylate cyclase-activating polypeptide causes increased tyrosine phosphorylation of focal adhesion kinase and paxillin.
Topics: Cell Line, Tumor; Focal Adhesion Kinase 1; Humans; Paxillin; Phosphorylation; Pituitary Adenylate Cyclase-Activating Polypeptide; Signal Transduction; Tyrosine; Up-Regulation | 2012 |
Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.
Topics: Actins; Animals; Cell Adhesion; Cell Proliferation; Cytoskeletal Proteins; Cytoskeleton; DNA-Binding Proteins; Enzyme Activation; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Mice; Mutation; Paxillin; Phosphorylation; ras Proteins; Signal Transduction; Tyrosine | 2011 |
Mitomycin C retardation of corneal fibroblast migration via sustained dephosphorylation of paxillin at tyrosine 118.
Topics: Cell Movement; Epithelium, Corneal; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Humans; Immunoblotting; Mitomycin; Nucleic Acid Synthesis Inhibitors; Paxillin; Phosphorylation; Real-Time Polymerase Chain Reaction; Tyrosine; Wound Healing | 2012 |
Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Kinase 1; Gangliosides; Gene Expression; Gene Silencing; Humans; Osteosarcoma; Paxillin; Phosphorylation; Sialyltransferases; Signal Transduction; src-Family Kinases; Tyrosine | 2012 |
Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen; Drug Combinations; Focal Adhesions; Gene Expression Regulation; Humans; Laminin; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; src-Family Kinases; Time Factors; Tyrosine | 2013 |
Rhodocetin-αβ-induced neuropilin-1-cMet association triggers restructuring of matrix contacts in endothelial cells.
Topics: Binding, Competitive; Cell Movement; Cell-Matrix Junctions; Cells, Cultured; Cortactin; Crotalid Venoms; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; Integrin alpha2beta1; Neuropilin-1; Paxillin; Phosphorylation; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pseudopodia; Signal Transduction; Stress Fibers; Tyrosine; Vascular Endothelial Growth Factor A; Zyxin | 2013 |
α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.
Topics: Actinin; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cell Line, Tumor; Focal Adhesion Kinase 1; Focal Adhesions; HEK293 Cells; Humans; Microfilament Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Stress Fibers; Tyrosine; Zyxin | 2013 |
Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Brain; Cell Line, Tumor; Cell Proliferation; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Interleukins; Mass Spectrometry; Mice; Microscopy, Fluorescence; Molecular Sequence Data; NIH 3T3 Cells; Paxillin; Phosphorylation; Protein Binding; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Interleukin; RNA Interference; Tyrosine | 2013 |
Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Focal Adhesion Kinase 1; GRB2 Adaptor Protein; Immunoblotting; Integrins; Mice; Mice, Knockout; Paxillin; Phosphorylation; Protein Binding; Receptor-Like Protein Tyrosine Phosphatases, Class 4; RNA Interference; Signal Transduction; src Homology Domains; Tyrosine | 2014 |
Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.
Topics: Animals; Antigen Presentation; Autoimmunity; Cell Differentiation; Cell Movement; Cells, Cultured; Cytokines; Dendritic Cells; Focal Adhesion Kinase 2; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Paxillin; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 12; T-Lymphocytes; Tyrosine | 2014 |
Identification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cell Adhesion; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Chlorocebus aethiops; COS Cells; Humans; Mutation; Paxillin; Phosphorylation; Protein Binding; Tyrosine; Wound Healing | 2014 |
Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.
Topics: Active Transport, Cell Nucleus; Animals; Antihypertensive Agents; Apoptosis; Becaplermin; Benzamides; Cell Adhesion; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paxillin; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; Signal Transduction; Time Factors; Transfection; Tyrosine; Vascular Remodeling | 2014 |
Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.
Topics: Animals; Cell Adhesion; Cell Movement; Cell Proliferation; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Extracellular Matrix; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Humans; Integrins; Kidney Glomerulus; Membrane Proteins; Mice; Muscle Proteins; Neoplasm Proteins; Paxillin; Phosphorylation; Podocytes; Protein Binding; Recombinant Proteins; Signal Transduction; src Homology Domains; src-Family Kinases; Tyrosine | 2014 |
Phosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnover.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Female; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Immunoprecipitation; p21-Activated Kinases; Paxillin; Phosphorylation; Protein Binding; Rho Guanine Nucleotide Exchange Factors; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2015 |
Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Line; Cell Movement; Cytoskeletal Proteins; GTPase-Activating Proteins; HEK293 Cells; Humans; Male; Mice; Muscle Cells; Muscle, Smooth; Paxillin; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Tyrosine | 2015 |
Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.
Topics: Cell Line, Tumor; Colonic Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Paxillin; Phosphorylation; Receptor, Cholecystokinin B; Rho Guanine Nucleotide Exchange Factors; Tyrosine | 2015 |
Formaldehyde-induced paxillin-tyrosine phosphorylation and paxillin and P53 downexpression in Hela cells.
Topics: Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Environmental Pollutants; Formaldehyde; HeLa Cells; Humans; Paxillin; Phosphorylation; Tumor Suppressor Protein p53; Tyrosine | 2016 |
Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells.
Topics: Actins; Animals; Cell Adhesion; Cell Movement; Fibronectins; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Focal Adhesions; Muscle, Skeletal; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinolones; Regeneration; Satellite Cells, Skeletal Muscle; Signal Transduction; Sulfones; Sus scrofa; Swine; Tyrosine | 2016 |
Sulfatide interacts with and activates integrin αVβ3 in human hepatocellular carcinoma cells.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Humans; Integrin alphaVbeta3; Liver Neoplasms; Paxillin; Phosphorylation; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; src-Family Kinases; Sulfoglycosphingolipids; Tyrosine | 2016 |
Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions.
Topics: Bacterial Proteins; Cell-Matrix Junctions; Cytoskeletal Proteins; Focal Adhesions; Humans; Image Processing, Computer-Assisted; Integrins; Luminescent Proteins; Microscopy, Fluorescence; Paxillin; Phosphorylation; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Tyrosine; Zyxin | 2016 |
Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells.
Topics: Adult; Aged; Aqueous Humor; Cell Adhesion; Cell Shape; Cells, Cultured; Culture Media, Conditioned; Dexamethasone; Extracellular Matrix Proteins; Focal Adhesions; Glaucoma; Humans; Intraocular Pressure; Mechanotransduction, Cellular; Middle Aged; Mutation; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; RNA Interference; Stress Fibers; Time Factors; Trabecular Meshwork; Transfection; Transforming Growth Factor beta2; Tyrosine; Young Adult | 2017 |
[Regulation of paxillin tyrosine phosphorylation via inhibition of c-Abl kinase to protect ventilator induce lung injury in vivo in rats].
Topics: Animals; Male; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-abl; Rats, Sprague-Dawley; Tyrosine; Ventilator-Induced Lung Injury | 2017 |
Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Movement; Dual Specificity Phosphatase 3; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesions; Gene Knockout Techniques; Humans; Integrins; Mice; Mice, Inbred C57BL; Mice, Knockout; Paxillin; Phosphorylation; Tyrosine | 2017 |
Mutant FGFR3 associated with SADDAN disease causes cytoskeleton disorganization through PLCγ1/Src-mediated paxillin hyperphosphorylation.
Topics: Achondroplasia; Amino Acid Substitution; Animals; Cell Line, Transformed; Cell Line, Tumor; Chondrocytes; Cytoskeleton; Humans; Mice; Mutation; Paxillin; Phospholipase C gamma; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Transport; Receptor, Fibroblast Growth Factor, Type 3; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Thanatophoric Dysplasia; Tyrosine | 2018 |
Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse.
Topics: Actins; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Humans; Immunological Synapses; Integrin alpha4beta1; Intercellular Adhesion Molecule-1; Jurkat Cells; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Paxillin; Phosphorylation; Receptors, Antigen, T-Cell; Signal Transduction; Talin; Tyrosine; Vascular Cell Adhesion Molecule-1; Vinculin | 2018 |
Intracellular Progesterone Receptor and cSrc Protein Working Together to Regulate the Activity of Proteins Involved in Migration and Invasion of Human Glioblastoma Cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; CSK Tyrosine-Protein Kinase; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Glioblastoma; Humans; Neoplasm Invasiveness; Paxillin; Phosphorylation; Progesterone; Protein-Tyrosine Kinases; Receptors, Progesterone; RNA, Small Interfering; Signal Transduction; Tyrosine | 2021 |
Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss.
Topics: Cell Line; Endothelial Cells; Humans; Lipopolysaccharides; Lung; Mitochondrial Dynamics; Paxillin; Phosphorylation; Reactive Oxygen Species; Tyrosine | 2021 |
Folding and Binding Mechanisms of the SH2 Domain from Crkl.
Topics: Nuclear Proteins; Oncogenes; Paxillin; Phosphorylation; Protein Binding; src Homology Domains; Tyrosine | 2022 |
Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
Topics: Breast Neoplasms; Cell Movement; Female; Humans; Paxillin; Phosphorylation; Tyrosine | 2023 |