pasireotide has been researched along with 1-4-7-10-tetraazacyclododecane--1-4-7-10-tetraacetic-acid* in 2 studies
2 other study(ies) available for pasireotide and 1-4-7-10-tetraazacyclododecane--1-4-7-10-tetraacetic-acid
| Article | Year |
|---|---|
Design, Synthesis, and Biological Evaluation of
Most of the radiolabeled somatostatin analogues (SSAs) are specific for subtype somatostatin receptor 2 (SSTR Topics: Animals; Cell Line, Tumor; Drug Design; Female; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Somatostatin; Somatostatin; Xenograft Model Antitumor Assays | 2018 |
Medicinal chemistry of somatostatin analogs leading to the DTPA and DOTA conjugates of the multi-receptor-ligand SOM230.
The somatostatin field has been a success story in terms of medicinal chemistry and drug discovery offering a variety of therapeutic opportunities. A rational medicinal chemistry approach capitalising on structure activity relationships has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin analog which exhibits multi-receptor binding to human somatostatin receptor (SSTR) subtypes (SSTR 1-5). Recently, we extended this research utilising the hydroxproline urethane extension of SOM230 for the attachment of the chelators DTPA and DOTA, which enable early diagnosis of SSTR positive tumors and radiotherapy. Topics: Chelating Agents; Heterocyclic Compounds, 1-Ring; Humans; Hydroxyproline; Isotope Labeling; Neoplasms; Pentetic Acid; Receptors, Somatostatin; Somatostatin; Technology, Pharmaceutical; Urethane | 2005 |