Compounds > parthenolide

parthenolide and sesquiterpenes

parthenolide has been researched along with sesquiterpenes in 527 studies

Research

Studies (527)

TimeframeStudies, this research(%)All Research%
pre-19909 (1.71)18.7374
1990's24 (4.55)18.2507
2000's187 (35.48)29.6817
2010's240 (45.54)24.3611
2020's67 (12.71)2.80

Authors

AuthorsStudies
Chan, YM; el-Feraly, FS1
Cole, JR; Hoffmann, JJ; Torrance, SJ; Widehopf, RM1
Hausen, BM; Schmidt-Löffler, P; Schulz, KH; Wallhöfer, L1
Hoult, JR; Knight, DW; Salan, U; Sumner, H1
Awang, DV; Dawson, BA; Heptinstall, S; Kindack, D; Knight, DW; May, J1
Barsby, RW; Hoult, JR; Knight, DW; Salan, U1
Groenewegen, WA; Heptinstall, S1
Hausen, BM1
Che, CT; Farnsworth, NR; Fong, HH; Mondranondra, IO; Rimando, AM; Vajrodaya, S1
Groenewegen, WA; Heptinstall, S; Loesche, W; Spangenberg, P1
Pugh, WJ; Sambo, K1
Barrett, ML; Lewis, GP; O'Neill, LA1
Hausen, BM; Osmundsen, PE1
Atal, CK; Dhar, KL; Sethi, VK; Thappa, RK1
Konopa, J; Woynarowski, JM1
Hamburger, M; Hay, AJ; Hostettmann, K; Hoult, JR1
Castañeda-Acosta, J; Fischer, NH; Vargas, D1
Béjar, E1
Fischer, NH; Hwang, D; Jang, BC; Kim, JK; Lee, W; Tak, H1
Carty, HC1
Hayataka, K; O'Connor, MF; Parker, KK; Weber, JT1
Colson, N; Hayataka, K; Medora, R; O'Connor, MF; Parker, KK; Russo, EB; Weber, JT1
Andersen, KE; Menné, T; Orion, E; Paulsen, E1
Cantrell, CL; Castañeda-Acosta, J; Fischer, NH; Franzblau, SG; Lu, T; Quijano, L1
Giner, RM; Máñez, S; Mordujovich de Buschiazzo, P; Recio, MC; Ríos, JL; Schinella, GR1
Arnason, JT; Birnboim, HC; Ross, JJ1
Buschiazzo, H; de Balsa, EM; Mañez, S; Mordujovich de Buschiazzo, P; Schinella, G; Tournier, H1
Menendez, IY; Wong, HR1
Kou, X; Stevenson, D; Zhou, JZ1
Castellano, D; Galindo, JC; Macías, FA; Velasco, RF1
Dröge, W; Hehner, SP; Hofmann, TG; Schmitz, ML1
Bugno, M; Kasza, A; Kordula, T; Sobota, R; Szwed, M1
Jain, NK; Kulkarni, SK1
Dietrich, JB; Kuchler-Bopp, S; Zaepfel, M2
Fiedler, MA; Mazor, RL; Menendez, IY; Ryan, MA; Wong, HR1
Doppler, W; Geymayer, S1
Lentsch, AB; Miller, RD; Molestina, RE; Ramirez, JA; Summersgill, JT1
Akao, S; Fujiwara, H; Fukuda, K; Hibiya, Y; Mutoh, M; Ohno, Y; Yamashita, K1
Bhat-Nakshatri, P; Boswell, SH; Gelfanov, V; Goulet, RJ; Nakshatri, H; Newton, TR; Nozaki, S; Patel, NM; Rice, S; Shortle, NH; Sledge, GW1
Bonilla, LE; Cutlan, AR; Erwin, JE; Simon, JE1
Hong, YS; Kim, HS; Kim, KW; Koo, TH; Lee, JH; Lee, JJ; Park, YJ1
Nakshatri, H; Nozaki, S; Sledge, GW1
Chung, SW; Kang, BY; Kim, TS1
Liu, X; Piela-Smith, TH1
Blum, D; Nissou, MF; Torch, S; Verna, JM1
Castro, V; García-Piñeres, AJ; Merfort, I; Mora, G; Pahl, HL; Schmidt, TJ; Strunck, E1
Crews, CM; Elofsson, M; Koh, B; Kwok, BH; Ndubuisi, MI1
Cabrini, G; Melotti, P; Nicolis, E; Pavirani, A; Rolfini, R; Tamanini, A1
Datta, A; Mittra, S; Singh, A; Singh, SK1
Cai, Y; Liu, XY; Lu, Y; Song, XK; Tu, PF; Wu, LJ; Zheng, QT; Zhu, H1
Abourashed, EA; Khan, IA1
Denenberg, A; Hake, PW; Wong, HR; Zingarelli, B1
Chung, SW; Kang, SN; Kim, HJ; Kim, SH; Kim, TS; Lee, MH1
Bolay, H; Chiarugi, A; Moskowitz, MA; Reuter, U1
Bömmel, H; Duschl, A; Heim, M; Moser, R; Panski, A; Schnyder, B; Schnyder-Candrian, S1
Hake, PW; Malhotra, V; O'Connor, M; Sheehan, M; Wong, HR; Zingarelli, B1
Crews, CM; Elofsson, M; Koh, BD; Kwok, BH; Ndubuisil, MI; Vervoort, J1
Choi, YK; Kim, DG; Liu, MJ; Won, YS; You, KR1
Kim, DG; Lee, SY; Song, CH; Wen, J; You, KR1
Arrighi, JF; Aubry, JP; Furue, M; Hauser, C; Uchi, H1
Cobb, SE; Nelson, MH; Shelton, J1
Blanco, J; Egido, J; Gómez-Guerrero, C; Hernández-Vargas, P; Kopp, J; López-Franco, O; Sanjuán, G; Suzuki, Y; Yo, Y1
Baumann, S; Giaisi, M; Krammer, PH; Li-Weber, M; Treiber, MK1
Engels, S; Fiebich, BL; Heinrich, M; Lieb, K1
Bogdanowicz, P; Dudhia, J; Legendre, F; Pujol, JP1
Giaisi, M; Krammer, PH; Li-Weber, M; Treiber, MK1
Chiarugi, A1
Beranek, JT1
D'Ambrosio, M; Guerriero, A; Kaneider, NC; Neukirch, H; Wiedermann, CJ1
Cory, AH; Cory, JG; Edwards, CC; Hall, JG1
Egido, J; Esbrit, P; Hernández-Presa, MA; Martín-Ventura, JL; Ortega, L; Ortego, M1
Darzynkiewicz, Z; Halicka, DH; Pozarowski, P1
Pestka, JJ; Smolinski, AT1
Hake, PW; Sheehan, M; Wong, HR; Zingarelli, B1
Fink, MP1
Aldieri, E; Atragene, D; Bergandi, L; Bosia, A; Costamagna, C; Ghigo, D; Riganti, C1
Koj, A; Witek-Zawada, B1
Abourashed, EA; Khan, IA; Khan, SI; Walker, LA1
Arribas, A; Blanco-Colio, LM; Egido, J; Gómez-Hernández, A; Martín-Ventura, JL; Muñoz-García, B; Ortega, L; Tuñón, J1
Devaraj, S; Jialal, I; Kumaresan, PR1
Chung, KS; Hoe, KL; Jang, YJ; Kim, DU; Maeng, PJ; Oh, GT; Park, SK; Ryoo, SW; Won, M; Yoo, HS1
Ong, CN; Shen, HM; Shi, X; Won, YK1
Armstrong, V; Curry, EA; Fife, K; Murry, DJ; Nakshatri, H; O'Connell, M; Sweeney, CJ; Yoder, C1
Fu, GS; Lin, XX; Shan, J; Weng, SX1
Ong, CN; Shen, HM; Zhang, S2
Chandrasekar, B; deGraffenried, LA; Donzis, E; Freeman, JW; Friedrichs, WE; Hidalgo, M; Silva, J; Weiss, GR1
Chilvers, ER; Cowburn, AS; Deighton, J; Walmsley, SR1
García-Piñeres, AJ; Lindenmeyer, MT; Merfort, I1
Groesdonk, HV; Senftleben, U1
Lin, ZN; Ong, CN; Shen, HM; Shi, X; Yang, CF; Zhang, S1
Bhat-Nakshatri, P; Nakshatri, H; Rice, SE1
An, W; Chen, L; Cui, W; Du, J; Hao, YM; Li, YJ; Liu, F; Liu, SY; Tian, ZJ; Zhang, H; Zu, XG1
Feng, HT; Joyce, DA; Steer, JH; Xu, J; Yip, KH; Zheng, MH1
Feltenstein, MW; Fischer, NH; Schühly, W; Sufka, KJ; Warnick, JE1
Bocca, C; Bozzo, F; Gabriel, L; Miglietta, A1
de Souza, W; Dias Filho, BP; Garcia Cortez, DA; Morgado-Díaz, JA; Nakamura, CV; Tiuman, TS; Ueda-Nakamura, T1
Chilvers, ER; Condliffe, AM; Cowburn, AS; Cramer, T; Farahi, N; Johnson, N; Johnson, RS; Peyssonnaux, C; Print, C; Sobolewski, A; Walmsley, SR1
Clarke, R; Nehra, R; Riggins, RB; Zwart, A1
Chiao, P; Su, H; Xiao, Y; Zhong, G; Zhong, Y; Zhou, Z1
Guzman, ML; Howard, DS; Jordan, CT; Karnischky, L; Li, X; Peterson, DR; Rossi, RM1
Giaisi, M; Krammer, PH; Li-Weber, M; Palfi, K1
Akao, Y; Iinuma, M; Matsuura, N; Nakagawa, Y; Nakayama, T; Naoi, M; Nozawa, Y; Yi, K1
Jang, JH; Surh, YJ1
Guzdek, A; Koj, A; Rokicki, M; Stalińska, K1
Kim, DG; Kim, IH; Kim, JH; Liu, L; Park, JH; You, KR1
Chen, C; Jain, MR; Jeong, WS; Keum, YS; Kim, JH; Kong, AN; Li, W; Shen, G1
Marshall, MS; Nakshatri, H; Schmidt, CM; Sweeney, CJ; Wiebke, EA; Yip-Schneider, MT1
Antolín, I; García-Santos, G; Herrera, F; Martin, V; Rodriguez, C; Rodriguez-Blanco, J1
D'Arcangelo, C; Di Primio, R; Mazzanti, L; Salvolini, E; Trubiani, O; Vignini, A1
Fonseca, JM; Rajapakse, NC; Riley, MB; Rushing, JW; Thomas, RL1
Badve, S; Campbell, RA; Kumar, S; Mehrotra, S; Murry, DJ; Nakshatri, H; Roman, Y; Sadaria, MR; Sheridan, C; Shortle, NH; Sweeney, CJ1
Bogdanowicz, P; Boumediene, K; Legendre, F; Pujol, JP1
Kim, DG; Kim, JH; Kim, YT; Lee, SO; Liu, L; You, KR1
Asamitsu, K; Hasegawa, J; Okamoto, T; Tanaka, K1
Greco, R; Morazzoni, P; Nappi, G; Riva, A; Sandrini, G; Tassorelli, C1
Jia, Y; Turek, JJ1
Ong, CN; Shen, HM; Won, YK1
Hanakawa, Y; Hashimoto, K; Kagami, S; Kakinuma, T; Komine, M; Tamaki, K1
Guzman, ML; Jordan, CT1
Laguna, JC; Merlos, M; Planavila, A; Sánchez, RM; Vázquez-Carrera, M1
Jové, M; Laguna, JC; Merlos, M; Planavila, A; Sánchez, RM; Vázquez-Carrera, M1
Frankfater, C; Fronczek, FR; Schühly, W; Slattery, M1
Kozak, A; Kozak, W; Wrotek, S1
Asahina, A; Kagami, S; Kakinuma, T; Komine, M; Nakamura, K; Saeki, H; Sasaki, K; Tamaki, K; Tsunemi, Y1
Zhong, D; Zhong, M; Zhu, R1
Asaba, K; Hashimoto, K; Iwasaki, Y; Nishiyama, M; Taguchi, T; Takao, T1
Chen, F; Haley-Zitlin, V; He, G; Huang, G; Kim, HJ; Rushing, JW; Wang, X; Wu, C1
Duke, VM; Ganeshaguru, K; Hoffbrand, AV; Jones, DT; Kottaridis, PD; Lowdell, MW; Mehta, AB; North, JM; Prentice, AG; Steele, AJ; Wickremasinghe, RG; Yogashangary, BC1
Bruze, M; Gruvberger, B; Hindsén, M; Lundh, K; Möller, H; Svensson, A1
Choi, JH; Heon Seo, K; Im, SY; Jun Park, S; Kim, HA; Kim, KJ; Ko, HM; Lee, HK1
Crews, CM; Gough, JD1
Cui, X; Eichacker, PQ; Fitz, Y; Hsu, L; Li, X; Li, Y1
Blanco, J; Egido, J; Gómez-Guerrero, C; Hernández-Vargas, P; López-Franco, O; Ortega, L; Ortiz-Muñoz, G; Sanjuán, G; Suzuki, Y1
Gage, EA; Klein, PJ; Ralstin, MC; Schmidt, CM; Wiebke, EA; Yip-Schneider, MT1
Baguley, BC; Ching, LM; Wang, LC; Woon, ST1
Crawford, S; Kraak, MM; Nobert, GS1
Avula, B; Joshi, VC; Khan, IA; Navarrete, A1
Chung, EY; Kim, BH; Kim, Y; Kim, YS; Lee, CK; Lee, JY; Min, KR; Reddy, AM; Ryu, SY; Seo, JH1
Bhat-Nakshatri, P; Cheng, L; DeGrado, T; Gokmen-Polar, Y; Hutchins, GD; Jayaprakasan, V; Kelich, S; Miller, KD; Miller, MA; Nakshatri, H; Shanmugam, R; Sledge, GW; Sweeney, CJ; Yip-Schneider, M; Zheng, QH1
Basalo, C; Hamburger, M; Mohn, T1
Adachi, M; Hayashi, T; Imai, K; Ishida, T; Kawamura, R; Sakamoto, H; Shinomura, Y; Wang, W1
Chen, ZC; Li, QB; Lü, J; Shao, J; You, Y; Zhong, ZD; Zou, P1
Coimbra, TM; Costa, RS; Francescato, HD; Scavone, C1
Figulla, HR; Foerster, M; Fritzenwanger, M; Krack, A; Kuethe, F; Meusel, K1
Kishida, Y; Myoui, A; Yoshikawa, H1
El Mabrouk, M; Sylvester, J; Zafarullah, M1
Berger, M; DiDonato, J; Li, J; Masters, S; Saadane, A1
Booz, GW; Bowers, MC; Dado, J; Kurdi, M1
Hamilton, T; Mandal, P1
Cho, ML; Jhun, JY; Jung, YO; Kang, CM; Kim, HY; Min, JK; Oh, HJ; Park, JS; Park, SH1
Arai, Y; Inoue, H; Nakai, Y; Nakayama, M; Nishimura, K; Nonomura, N; Oka, D; Okuyama, A; Shiba, M; Takayama, H1
Andersen, KE; Christensen, LP; Paulsen, E1
Jordan, CT1
Feng, L; Shao, X; Tang, X; Wu, N; Yao, H; Yao, K1
Donauer, J; Kern, C; Kreutz, C; Lindenmeyer, MT; Merfort, I; Porath, D; Schwager, J; Sparna, T; Timmer, J; Wilpert, J1
Auh, S; Blokh, L; Gagnon, I; Hamann, KJ; Long, C; Qin, Y1
Booz, GW; Kurdi, M1
Kobori, H; Ozawa, Y1
Ausseil, F; Barette, C; Cintrat, JC; David, B; Fonrose, X; Lafanechère, L; Massiot, G; Masson, V; Pouny, I; Rousseau, B; Soleilhac, E1
Ducore, JM; Storms, DH; Zunino, SJ2
Crooks, PA; Nakshatri, H; Neelakantan, S; Noble, S; Ralstin, M; Schmidt, CM; Sweeney, CJ; Wu, H; Yiannoutsos, C; Yip-Schneider, MT1
Czyz, M; Duechler, M; Stańczyk, M; Stepnik, M1
Arora, TS; Gopal, YN; Van Dyke, MW1
Becker, MW; Bennett, JM; Carroll, M; Corbett, CA; Crooks, PA; Guzman, ML; Hassane, DC; Jordan, CT; Lachowicz, JL; Li, X; Liesveld, JL; Matthews, W; Neelakantan, S; Rossi, RM; Sullivan, E; Sweeney, CJ; Vaughan, A1
Crooks, PA; Fang, F; Rangnekar, VM; St Clair, DK; St Clair, WH; Sun, Y; Warren, GW1
Pajak, B1
Cortez, DA; Ferreira, IC; Filho, BP; Izumi, E; Morello, LG; Morgado-Díaz, JA; Nakamura, CV; Ueda-Nakamura, T; Yamada-Ogatta, SF1
Bai, J; Gu, P; Margolick, JB; Zhang, H; Zhang, Y; Zhou, J1
Inman, AO; Monteiro-Riviere, NA; Riviere, JE1
Ahlborg, N; Bruze, M; Gruvberger, B; Karlberg, AT; Masjedi, K; Wahlkvist, H; Zuber, B1
Anthonavage, M; Garay, M; Liebel, F; Lyte, P; Martin, K; Oddos, T; Shapiro, S; Southall, M; Sur, R; Tierney, N1
Benjamin, L; Chin-Sinex, H; Comerford, K; Datzman, N; Gomez-Millan, J; Hardacre, M; Mehta, S; Mendonca, MS; Nakshatri, H; Nye, M; Patino, F; Sweeney, C1
Augsburger, LL; Jin, P; Madieh, S1
Afshari, LK; Azam, M; Bidja, AH; Feeney, RB; Pagán, OR; Rowlands, AL; Roy, DM; Urban, KR1
Pagán, OR; Rowlands, AL1
Anderson, KN; Bejcek, BE1
Akao, Y; Fujita, Y; Hamada, N; Iinuma, M; Ito, M; Itoh, T; Matsuura, N; Nozawa, Y; Umemura, K1
Abboud, R; Carroll, M; Corbett, C; Guzman, ML; Hassane, DC; Jordan, CT; Li, X; Liesveld, JL; Young, F1
Abonour, R; Boswell, HS; Crean, CD; Farag, SS; Nakshatri, H; Shanmugam, R; Suvannasankha, A1
Hatashita, M; Hayashi, A; Hayashi, S; Kitai, R; Matsumoto, H; Shioura, H1
Endo, D; Gon, Y; Hashimoto, S; Matsumoto, K; Miyata, N; Nunomura, S; Ra, C; Yamashita, K1
Du, J; Guo, J; Li, T; Liu, Y; Lu, WL; Wang, GL; Wang, JC; Wu, JW; Zhang, Q; Zhang, X1
Breger, JC; Durfor, CN; Hitchins, VM; Langone, JJ; Lyle, DB; Shallcross, JC1
Berry, PA; Birnie, R; Bryce, SD; Collins, AT; Droop, A; Dussupt, V; Hyde, CF; Lang, SH; Lewis, JL; Maitland, NJ; Roome, C; Stower, MJ1
Diamandis, EP; Paliouras, M1
Gajkowska, B; Orzechowski, A; Pajak, B1
Brzana, W; Jabłoński, M; Majdan, M; Mitura, A; Parada-Turska, J; Rzeski, W1
Crooks, PA; Nasim, S1
Rk, W; Zhang, FC; Zhou, HQ1
Hashizume, M; Hayakawa, N; Mihara, M1
Chen, Z; Kong, F; Li, Q; Tian, X; You, Y; Yu, K; Zhao, J; Zou, P1
Mahesh, R; Pandey, DK; Radha, R; Rajkumar, R1
Bae, YM; Choi, MH; Hong, ST; Kim, YJ1
Limon-Flores, AY; Ramos, G; Ullrich, SE1
Liebel, F; Lyte, P; Martin, K; Shapiro, S; Southall, M; Sur, R1
Cortez, DA; Dias Filho, BP; Nakamura, CV; Onozato, T; Ueda-Nakamura, T1
Figulla, HR; Foerster, M; Fritzenwanger, M; Jung, C; Meusel, K1
Aimiuwu, J; Bhasin, D; Chan, KK; Chen, P; Fuchs, JR; Huang, TH; Li, C; Li, PK; Liu, S; Liu, Z; Marcucci, G; Neviani, P; Pang, J; Pavlovicz, RE; Perrotti, D; Plass, C; Rush, L; Wang, H; Wu, J; Wu, LC; Xie, Z1
Alvarez, LD; Clarêncio, J; Costa, MF; Costa, SL; El-Bachá, RS; Lima, RM1
Duhagon, MA; Farrar, WL; Hurt, EM; Kalathur, M; Kawasaki, BT; Kim, YS; Milner, JA1
Tallman, M1
Choudary, A; Ghosh, S; Hu, Y; Li, R; Musi, N1
Bosisio, E; D'Ambrosio, M; Dell'Agli, M; Galli, GV1
Chanchorn, E; Gopal, YN; Van Dyke, MW1
Bosia, A; Doublier, S; Ghigo, D; Miraglia, E; Pescarmona, G; Riganti, C; Viarisio, D1
Kiuchi, H; Miyagawa, Y; Nakayama, J; Nonomura, N; Okuyama, A; Takao, T; Tsujimura, A; Yamamoto, K1
Adachi, M; Wang, W; Zhang, R; Zhou, J; Zhu, D1
Chin-Sinex, H; Hughes, W; Losch, A; Mendonca, MS; Miller, DA; Sweeney, C; Watson, C1
Aroeira, LS; Carvajal, G; Egido, J; Mezzano, SA; Ortiz, A; Rayego, S; Rodrigues-Díez, R; Rodriguez, JS; Rodríguez-Vita, J; Ruiz-Ortega, M; Sánchez-López, E; Selgas, R1
Konia, MR; Liu, H; Schaefer, S1
Crooks, PA; Guzman, ML; Jordan, CT; Nasim, S; Neelakantan, S1
Barochia, A; Cui, X; Eichacker, PQ; Li, X; Li, Y; Su, J1
Guo, C; Guo, Z; Jin, X; Qiu, L; Zhang, D1
Chen, S; Fang, L; Ma, J; Shan, J; Sui, MH; Wang, JA; Weng, SX; Xu, G1
Altuwaijri, S; Bhanot, UK; Chang, C; Chen, L; Deng, F; Gerald, WL; Korets, R; Lal, P; Lilja, HG; Scher, HI; Wenske, S; Zhang, L1
Li, Y; Xu, YH; Zhao, LJ1
Fang, LJ; Lu, GH; Shao, XT; Wang, S; Xu, T; Zhou, JY1
Lei, ZN; Li, T; Wang, L; Zeng, SL; Zhu, JB1
Cho, ML; Ju, JH; Kang, CM; Kim, HY; Kim, KW; Lee, SH; Li, X; Min, JK; Oh, HJ; Park, SH1
Czyz, M; Düchler, M; Koprowska, K; Lesiak, K; Nejc, D; Zalesna, I1
Bernstein, SH; Briehl, MM; Brookes, PS; Guzman, ML; Hilchey, SP; Jordan, CT; Maggirwar, SB; Nadtochiy, SM; Skalska, J1
Hatashita, M; Hayashi, A; Hayashi, S; Sakurai, H; Shioura, H; Tanaka, Y1
Bui-Nguyen, TM; Kumar, R; Martin, E; Murad, F; Pakala, SB; Sirigiri, DR1
Cureton, E; Curran, B; Dozier, K; Kwan, RO; Sadjadi, J; Victorino, GP1
Alnemri, ES; Datta, P; Fernandes-Alnemri, T; Juliana, C; Latz, E; Meng, R; Quong, AA; Scott, CP; Solorzano, L; Wu, J; Yu, JW1
Fleming, A; Goldsmith, P; Jankowski, J1
Fu, ZQ; Shao, QL; Shen, JL; Yao, L; Zhang, YJ; Zhao, XX1
Crooks, PA; St Clair, DK; St Clair, WH; Sun, Y; Xu, Y1
Czyz, M; Koprowska, K1
Chen, J; Shi, J; Sun, J; Wei, H; Yi, J1
Abdul-Sater, AA; Ojcius, DM; Padilla, EV; Saïd-Sadier, N1
Gao, L; Mitra, AK; Zucker, IH1
Gao, ZW; Guo, CB; Zhang, DL1
Deck, LM; Ferguson, JE; Hunsaker, LA; Shah, VO; Vander Jagt, DL1
Czyz, M; Koprowska, K; Lesiak-Mieczkowska, K; Szulawska-Mroczek, A; Wozniak, M1
Bedirli, A; Ofluoglu, E; Pasaoglu, H; Sakrak, O; Salman, B1
de las Pozas, A; Parrondo, R; Perez-Stable, C; Rai, P; Reiner, T1
Idris, AI; Krishnan, M; Landao-Bassonga, E; Mollat, P; Ralston, SH; Simic, P; Vukicevic, S1
Appaiah, H; Cheng, L; Crooks, P; Klaunig, J; Kusumanchi, P; Matthews, W; Nakshatri, H; Neelakantan, S; Peat, T; Shanmugam, R; Sweeney, CJ1
Andersen, KE; Christensen, LP; Fretté, XC; Paulsen, E1
Cai, MX; Huang, DS; Liu, JW; Ma, J; Wu, QS; Xie, HY; Xin, Y; Yang, P1
Cheong, JW; Eom, JI; Jeung, HK; Kim, JS; Kim, SJ; Kim, YR; Min, YH1
Chen, S; Dai, Y; Dent, P; Grant, S; Guzman, ML; Jordan, CT; Pei, XY; Wang, L; Yeung, SK1
Bommana, A; Bui-Nguyen, TM; Kumar, R; Pakala, SB; Rangparia, SS; Reddy, SDN1
Aoyama, S; Hashida, C; Hirasawa, N; Hong, J; Ishihara, K; Kimura, M; Ohuchi, K; Seyama, T; Zee, O1
Dyugovskaya, L; Ginsberg, D; Lavie, L; Lavie, P; Polyakov, A1
Balys, M; Corbett, CA; Crooks, PA; Guzman, ML; Hassane, DC; Jordan, CT; Minhajuddin, M; Rossi, RM; Sen, S; Wei, L1
Kim, DG; Kim, IH; Kim, JH; Lee, MJ; Yu, GR; Yun, BR1
Dias Filho, BP; Izumi, E; Nakamura, CV; Pelizzaro-Rocha, KJ; Tiuman, TS; Ueda-Nakamura, T1
Battastini, AM; Braganhol, E; Dalmolin, RJ; de Souza, LH; Gelain, DP; Moreira, JC; Pasquali, MA; Schröder, R; Zanotto-Filho, A1
Antoine, B; Capeau, J; Chapron, C; Kadiri, S; Leroyer, S; Quette, J; Vatier, C1
Andersen, KE; Paulsen, E4
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Arndt, HD; Fischer, D; Freund, RRA; Gobrecht, P1
Chen, Y; Gong, W; Huang, Q; Li, S; Long, H; Luo, C; Peng, F; Peng, X; Wang, Y; Wu, J; Xiao, J; Yin, B; Zhang, Y; Zhou, W1
Cai, N; Jin, X; Yang, Q; Zhang, Z1
Bedi, K; Caporizzo, MA; Chen, CY; Margulies, KB; Prosser, BL1
Chen, Y; Ding, Y; Ge, W; Guo, H; Hao, X; Hu, K; Li, A; Li, J; Li, Y; Liu, S; Wang, D; Wang, T; Xue, Q; Zhang, Q; Zhang, Y1
An, T; Cai, B; Chen, L; Duan, A; Ju, X; Kong, L; Li, X; Li, Y; Yang, Q1
Cong, C; Gao, D; Gao, W; He, Y; Li, L; Luo, L; Zhang, X1
Chai, Z; Li, J; Lu, L; Lu, W; Mao, J; Ran, D; Wu, S; Xie, C; Zhan, C; Zhang, Y; Zhou, J1
Contreras, JI; Karpf, AR; Kizhake, S; Kour, S; Natarajan, A; Rana, S; Robb, CM; Sonawane, YA; Zahid, M1
Jiang, S; Liang, P; Lv, H; Wu, H; Zhang, Z1
Gao, D; Gao, W; Li, C; Li, L; Li, Z; Wei, S; Zhang, X1
Jin, X; Lu, X; Lv, H; Zhang, Z1
Bahrami, M; Dadmehr, M; Kamalinejad, M; Latifi, SA; Seif, F1
Wang, J; Wang, Z; Yuan, L; Zhang, D1
Du, G; Jia, X; Li, Y; Liu, Q; Wang, S; Zeng, B; Zhang, C1
Chen, Y; Li, Q; Sun, S; Wang, J; Yu, L; Zhang, C1
Aghaee, A; Ahmadi, SZ; Ghorbanpour, M; Hadian, J1
Ghorbani-Abdi-Saedabad, A; Hanafi-Bojd, MY; Hoshyar, R; Mollaei, H; Parsamanesh, N; Tayarani-Najaran, Z1
Chen, C; Gan, X; Sun, L; Tang, J; Wen, G; Xu, F; Yu, B; Yuan, W; Zeng, Q; Zhang, W; Zhu, L1
Botha, CJ; Ferreira, GCH; Mathe, YZ; Venter, EA1
Chen, H; Hu, W; Ou, Y; Sun, P; Wu, D; Wu, N; Yang, Z1
Byun, JH; Hwang, SC; Kang, YH; Oh, SH; Park, JH1
Bajrami, B; Deng, B; Howell, AR; Riel, LP; Wang, L; Yao, X1
Mehri, S; Mohammadi, S; Nikbakht, M; Sahmani, M; Zahedpanah, M1
Cao, Y; Li, Y; Liu, D; Liu, M; Yang, Y1
Fan, S; Han, Y; Li, L; Liu, D; Liu, L; Qin, T; Ren, X; Zhang, H1
Glaspole, I; Jaffar, J; Symons, K; Westall, G1
Krzyściak, W; Papież, MA; Siodłak, O1
He, Y; Liu, Q; Wang, W1
Cheng, Y; Hu, J; Li, Y; Liu, S; Pan, X; Shen, L; Zeng, B; Zheng, K1
Fan, D; Ju, X; Kong, L; Li, Y; Su, G; Yang, Q; Zhang, S; Zhu, Y1
Cui, ZY; Dou, JY; Jiang, YC; Lian, LH; Nan, JX; Song, J; Wang, G; Wu, YL; Zhang, J1
Brodowski, L; Meyer, N; Schröder-Heurich, B; von Kaisenberg, C; von Versen-Höynck, F1
Fontes-Ribeiro, CA; Leitão, RA; Silva, AP1
Chinta, PK; Nandave, M; Pal, AK; Tambe, S; Umrani, D1
Darbahani, M; Ebrahimi, A; Khosrowshahli, M; Rahaie, M1
Cui, M; Huang, LT; Wang, JH; Wang, Z1
Cao, Y; Chen, Y; Feng, X; Hu, J; Jia, Y; Li, L; Liu, F; Qiao, S; Wang, B; Xu, S; Zhou, Q; Zhou, Y1
Zhang, K; Zhang, M; Zhang, R; Zhang, X; Zhang, Z1
An, T; Liu, F; Lu, Y; Yin, H1
Al-Harrasi, A; Gollahon, LS; Halim, SA; Hussain, F; Khan, A; Khan, ZS; Munir, MT; Rahman, SM; Santos, JM; Sufian, HB; Zahid, MK1
Dong, T; Shi, Y; Wang, Y; Xiao, W; Xie, Z; Yao, M; Yuan, Y; Zeng, B1
Cai, C; Ding, W; Jiang, Q; Wang, J; Zhu, X1
Lei, H; Shan, H; Shi, Y; Sun, D; Wan, J; Wu, Y; Xia, L; Xu, H; Xu, Z; Zhou, A; Zou, Z1
Dong, Y; Li, J; Qian, X1
Deng, Y; Gao, W; Gu, H; Jiang, X; Li, A; Wen, J; Zhang, X; Zhu, Y1
Fan, X; Liu, G; Liu, J; Miao, L; Peng, Q; Song, W; Yang, B; Zhang, P; Zhang, Y1
Chang, J; Han, N; Hu, X; Li, H; Li, J; Liang, B; Liu, W; Lu, C; Meng, J; Shi, L; Wang, C; Wang, X; Xing, D; Yang, S; Zeng, J; Zhang, R1
Bouwmeester, H; Kashkooli, AB; van der Krol, A; van Dijk, ADJ1
Gao, Z; Liu, X; Shen, Y; Wang, X1
Liu, X; Wang, X1
Linares-González, L; Navarro-Triviño, FJ; Prados-Carmona, Á; Ruiz-Villaverde, R; Velasco-Amador, JP1
Albalawi, RS; Bagher, AM; Binmahfouz, LS; Hareeri, RH; Shaik, RA1
Choi, JS; Jung, J; Kim, JM; Kim, SH; Yeo, SG1
Feng, L; Gao, J; Hu, J; Li, A; Liu, L; Qiu, B; Shen, Z; Zhang, C; Zhu, Y1
Alves, R; Geraldes, C; Gonçalves, AC; Jorge, J; Neves, J; Sarmento-Ribeiro, AB1
Bayram, C; Budak, H; Hacımüftüoğlu, A; Özkaraca, M; Sezen, S; Toraman, E1
Bouchal, P; Bouchalova, P; Janacova, L; Jilkova, K; Lapcik, P; Müller, P; Potesil, D; Sulc, P1
Elwany, NE; Kabil, SL; Mohamed, NM; Rashed, HE1
Ávila-Gálvez, MÁ; Bosch, D; Brito, MA; Cankar, K; Dos Santos, CN; Figueira, I; Marques, D1

Reviews

21 review(s) available for parthenolide and sesquiterpenes

ArticleYear
Probing protein function with small molecules.
    Ernst Schering Research Foundation workshop, 2006, Issue:58

    Topics: Animals; Biotinylation; Combinatorial Chemistry Techniques; Drug Design; Drug Evaluation, Preclinical; Genomics; Green Fluorescent Proteins; Humans; Ketones; Models, Chemical; Molecular Probe Techniques; Nanotechnology; Oligopeptides; Phosphorylation; Protein Binding; Proteins; Receptors, Androgen; Recombinant Fusion Proteins; Serine; Sesquiterpenes; Signal Transduction; Ubiquitin-Protein Ligases

2006
The leukemic stem cell.
    Best practice & research. Clinical haematology, 2007, Volume: 20, Issue:1

    Topics: Antineoplastic Agents; Drug Evaluation, Preclinical; Humans; Leukemia; Neoplastic Stem Cells; Sesquiterpenes; Thiadiazoles

2007
Antiapoptotic proteins as targets for bioactive compounds.
    Polish journal of veterinary sciences, 2007, Volume: 10, Issue:2

    Topics: Butyrates; Colonic Neoplasms; Fatty Acids; Humans; Immunotherapy; Phytotherapy; Sesquiterpenes; Tanacetum parthenium

2007
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
    Folia histochemica et cytobiologica, 2008, Volume: 46, Issue:2

    Topics: Animals; Apoptosis; Humans; Mitochondria; Neoplasms; NF-kappa B; Sesquiterpenes; STAT Transcription Factors

2008
Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate.
    Expert opinion on investigational drugs, 2009, Volume: 18, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Humans; Mice; NF-kappa B; Pyruvates; Sepsis; Sesquiterpenes

2009
[Molecular mechanisms of parthenolide's action: Old drug with a new face].
    Postepy higieny i medycyny doswiadczalnej (Online), 2010, Mar-16, Volume: 64

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Neoplasms; Neoplastic Stem Cells; Sesquiterpenes

2010
Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities.
    Inflammation, 2012, Volume: 35, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Cytochromes c; Humans; I-kappa B Kinase; Inflammation; Neoplasms; NF-kappa B; Plant Extracts; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; STAT Transcription Factors; Tanacetum parthenium; Transcription, Genetic

2012
Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide.
    Anti-cancer drugs, 2012, Volume: 23, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Humans; Molecular Structure; Neoplasms; NF-kappa B; Plants, Medicinal; Quantitative Structure-Activity Relationship; Sesquiterpenes; Xenograft Model Antitumor Assays

2012
Parthenium dermatitis.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, Volume: 12, Issue:1

    Topics: Allergens; Asteraceae; Dermatitis, Allergic Contact; DNA Adducts; Humans; Lactones; Sesquiterpenes; Thymidine; Ultraviolet Rays

2013
How close are we to targeting the leukemia stem cell?
    Best practice & research. Clinical haematology, 2012, Volume: 25, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Drug Delivery Systems; Glutathione; Humans; Leukemia; Neoplastic Stem Cells; Oxidative Stress; Sesquiterpenes

2012
Parthenolide: from plant shoots to cancer roots.
    Drug discovery today, 2013, Volume: 18, Issue:17-18

    Topics: Animals; Antineoplastic Agents, Phytogenic; Humans; Molecular Structure; Neoplastic Stem Cells; Phytotherapy; Plant Shoots; Plants, Medicinal; Sesquiterpenes; Structure-Activity Relationship; Tanacetum parthenium

2013
Sesquiterpene lactones: adverse health effects and toxicity mechanisms.
    Critical reviews in toxicology, 2013, Volume: 43, Issue:7

    Topics: Animals; Anti-Infective Agents; Antimalarials; Artemisinins; Cardiovascular System; Central Nervous System; DNA Damage; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Tract; Insecta; Kidney; Lactones; Liver; Mammals; Plant Extracts; Plant Leaves; Sesquiterpenes; Skin Diseases; Teratogenesis

2013
Combined effect of parthenolide and various anti-cancer drugs or anticancer candidate substances on malignant cells in vitro and in vivo.
    Mini reviews in medicinal chemistry, 2014, Volume: 14, Issue:3

    Topics: Animals; Antineoplastic Agents; Drug Interactions; Humans; Neoplasms; Sesquiterpenes

2014
α-Methylene-γ-lactones as a novel class of anti-leukemic agents.
    Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:5

    Topics: Animals; Antineoplastic Agents; Humans; Lactones; Leukemia; Neoplastic Stem Cells; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Guaiane

2014
Parthenolide could become a promising and stable drug with anti-inflammatory effects.
    Natural product research, 2015, Volume: 29, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Humans; Inflammation; Sesquiterpenes

2015
Sesquiterpene lactone engineering in microbial and plant platforms: parthenolide and artemisinin as case studies.
    Applied microbiology and biotechnology, 2016, Volume: 100, Issue:3

    Topics: Artemisinins; Bacteria; Biosynthetic Pathways; Metabolic Engineering; Plants; Sesquiterpenes

2016
Parthenolide and its Analogues: A New Potential Strategy for the Treatment of Triple-Negative Breast Tumors.
    Current medicinal chemistry, 2020, Volume: 27, Issue:39

    Topics: Apoptosis; Cell Line, Tumor; Humans; Neoplasm Recurrence, Local; Sesquiterpenes; Triple Negative Breast Neoplasms

2020
Advances in chemistry and bioactivity of parthenolide.
    Natural product reports, 2020, 04-01, Volume: 37, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Carboxypeptidases; Cyclization; Humans; Mitochondria; Molecular Structure; Sesquiterpenes; Sesquiterpenes, Germacrane; Stereoisomerism

2020
The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Antineoplastic Agents; Cell Line, Tumor; Neoplastic Stem Cells; Sesquiterpenes

2022
Sesquiterpene Lactones and Cancer: New Insight into Antitumor and Anti-inflammatory Effects of Parthenolide-Derived Dimethylaminomicheliolide and Micheliolide.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Anti-Inflammatory Agents; Humans; Lactones; Neoplasms; Sesquiterpenes; Sesquiterpenes, Guaiane

2022
Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents.
    Chinese journal of natural medicines, 2022, Volume: 20, Issue:11

    Topics: Antineoplastic Agents; Neoplasms; Plant Extracts; Sesquiterpenes; Tanacetum parthenium

2022

Trials

5 trial(s) available for parthenolide and sesquiterpenes

ArticleYear
Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.
    Investigational new drugs, 2004, Volume: 22, Issue:3

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Mass Spectrometry; Middle Aged; Neoplasms; Phytotherapy; Plant Preparations; Sesquiterpenes; Tanacetum parthenium

2004
Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium).
    Inflammopharmacology, 2009, Volume: 17, Issue:1

    Topics: Adult; Animals; Anti-Inflammatory Agents; Cells, Cultured; Dermatitis; Erythema; Female; Humans; Inflammation; Inflammation Mediators; Keratinocytes; Leukocytes, Mononuclear; Macrophages; Male; Mice; Middle Aged; Plant Extracts; Sesquiterpenes; Tanacetum parthenium; Young Adult

2009
TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes.
    Biochimica et biophysica acta, 2012, Volume: 1821, Issue:9

    Topics: Active Transport, Cell Nucleus; Adipocytes; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Cells, Cultured; Female; Gene Expression Regulation, Enzymologic; Humans; Inflammation; Interleukin-6; Intra-Abdominal Fat; Male; Metabolic Syndrome; Middle Aged; Obesity; PPAR delta; PPAR-beta; Sesquiterpenes; Sirtuin 1; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2012
Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
    Experimental hematology, 2013, Volume: 41, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Cell Line, Tumor; Ciclopirox; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Pyridones; Sesquiterpenes; TOR Serine-Threonine Kinases

2013
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
    The Journal of biological chemistry, 2013, Nov-22, Volume: 288, Issue:47

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD34; Dioxolanes; Female; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leukemia, Myeloid, Acute; Male; Oxidation-Reduction; Oxidative Stress; Sesquiterpenes; Tumor Cells, Cultured

2013

Other Studies

501 other study(ies) available for parthenolide and sesquiterpenes

ArticleYear
Isolation and characterization of the sesquiterpene lactones costunolide, parthenolide, costunolide diepoxide, santamarine, and reynosin from Magnolia grandiflora L.
    Journal of pharmaceutical sciences, 1978, Volume: 67, Issue:3

    Topics: Cyclization; Epoxy Compounds; Lactones; Oxidation-Reduction; Plant Extracts; Sesquiterpenes

1978
Cytotoxic agents from Michelia champaca and Talauma ovata: parthenolide and costunolide.
    Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cell Survival; Cells, Cultured; Humans; Neoplasms, Experimental; Phytotherapy; Plants, Medicinal; Sesquiterpenes

1977
Chrysanthemum allergy. Pt. II: Experimental studies on the causative agents.
    Archiv fur dermatologische Forschung, 1975, Volume: 251, Issue:3

    Topics: Adjuvants, Immunologic; Allergens; Animals; Benzofurans; Chromatography, Thin Layer; Chrysanthemum cinerariifolium; Dermatitis, Contact; Guinea Pigs; Humans; Immunologic Techniques; Injections, Intradermal; Insecticides; Lactones; Male; Plant Extracts; Plants; Sesquiterpenes; Skin Tests; Turpentine

1975
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components.
    Biochemical pharmacology, 1992, Jun-09, Volume: 43, Issue:11

    Topics: Animals; Cyclooxygenase Inhibitors; Cysteine; Lactones; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; Sesquiterpenes; Tanacetum parthenium; Thromboxane B2

1992
Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.). Estimation of commercial and authenticated feverfew products.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:5

    Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Plant Extracts; Plants, Medicinal; Quality Control; Sesquiterpenes; Tablets; Tanacetum parthenium

1992
Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:9

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Plant Extracts; Plants, Medicinal; Rabbits; Sesquiterpenes

1992
A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:8

    Topics: Blood Platelets; Calcimycin; Humans; Plant Extracts; Plants, Medicinal; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Serotonin Antagonists; Sesquiterpenes; Tanacetum parthenium

1990
A simple method of isolating parthenolide from Tanacetum and other sensitizing plants.
    Contact dermatitis, 1991, Volume: 24, Issue:2

    Topics: Humans; Plants, Medicinal; Sesquiterpenes; Solubility

1991
Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda.
    Pharmaceutical research, 1990, Volume: 7, Issue:12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Aporphines; Glucosides; Lactones; Phenylpropionates; Plant Extracts; Sesquiterpenes; Tumor Cells, Cultured

1990
Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups.
    The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:6

    Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Protein Electrophoresis; Cysteine; Humans; In Vitro Techniques; Indicators and Reagents; Plant Extracts; Plants, Medicinal; Platelet Aggregation; Sesquiterpenes; Sulfhydryl Compounds

1987
Prostaglandin synthetase inhibitors in feverfew.
    The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:10

    Topics: Bridged Bicyclo Compounds; Cyclooxygenase Inhibitors; Monoterpenes; Plants, Medicinal; Prostaglandins; Sesquiterpenes

1988
Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect.
    British journal of clinical pharmacology, 1987, Volume: 23, Issue:1

    Topics: Drug Antagonism; Humans; In Vitro Techniques; Interleukin-1; Interleukin-2; Lymphocyte Activation; Lymphocytes; Mitogens; Plants, Medicinal; Sesquiterpenes; Synovial Membrane; Tanacetum parthenium

1987
Contact allergy to parthenolide in Tanacetum parthenium (L.) Schulz-Bip. (feverfew, Asteraceae) and cross-reactions to related sesquiterpene lactone containing Compositae species.
    Acta dermato-venereologica, 1983, Volume: 63, Issue:4

    Topics: Animals; Cross Reactions; Dermatitis, Contact; Female; Guinea Pigs; Humans; Male; Middle Aged; Plant Extracts; Plants, Medicinal; Sesquiterpenes; Tanacetum parthenium

1983
Constituents of Michelia champaca and Lewis acid catalysed transformations of parthenolide into guaianolides.
    Planta medica, 1984, Volume: 50, Issue:4

    Topics: Chemical Phenomena; Chemistry; Lactones; Plants, Medicinal; Sesquiterpenes

1984
Inhibition of DNA biosynthesis in HeLa cells by cytotoxic and antitumor sesquiterpene lactones.
    Molecular pharmacology, 1981, Volume: 19, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; DNA Replication; DNA, Neoplasm; HeLa Cells; Humans; Phosphorylation; Sesquiterpenes; Thymidine; Time Factors; Uridine

1981
Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Cysteine; In Vitro Techniques; Lactones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phorbols; Plants; Rabbits; Sesquiterpenes

1994
Biomimetic transformations of parthenolide.
    Journal of natural products, 1993, Volume: 56, Issue:1

    Topics: Cyclization; Magnetic Resonance Spectroscopy; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship

1993
Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin.
    Journal of ethnopharmacology, 1996, Volume: 50, Issue:1

    Topics: Animals; Dextroamphetamine; Fenfluramine; Gastric Fundus; In Vitro Techniques; Muscle Contraction; Plants, Medicinal; Prazosin; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Antagonists; Sesquiterpenes

1996
Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases.
    Biochemical and biophysical research communications, 1996, Sep-24, Volume: 226, Issue:3

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclooxygenase 2; Cytokines; Enzyme Induction; Enzyme Inhibitors; Gene Expression; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Macrophages, Alveolar; Male; Mice; Mitogen-Activated Protein Kinases; Molecular Structure; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

1996
Herbal preparations under scientific scrutiny.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1996, Nov-01, Volume: 155, Issue:9

    Topics: Canada; Drug Approval; Humans; Migraine Disorders; Phytotherapy; Sesquiterpenes

1996
Rabbit cerebral cortex 5HT1a receptors.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1997, Volume: 117, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Dioxanes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Propranolol; Rabbits; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Sesquiterpenes; Spiro Compounds; Tritium

1997
Activity of Parthenolide at 5HT2A receptors.
    Journal of natural products, 1997, Volume: 60, Issue:6

    Topics: Animals; Binding, Competitive; Brain Chemistry; Cells, Cultured; In Vitro Techniques; Ketanserin; Kinetics; Rabbits; Rats; Receptors, Serotonin; Serotonin Antagonists; Sesquiterpenes

1997
Comparison of simultaneous patch testing with parthenolide and sesquiterpene lactone mix.
    Contact dermatitis, 1998, Volume: 38, Issue:4

    Topics: Asteraceae; Dermatitis, Allergic Contact; Humans; Patch Tests; Plants, Medicinal; Sesquiterpenes

1998
Antimycobacterial evaluation of germacranolides.
    Phytochemistry, 1998, Volume: 49, Issue:2

    Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Mycobacterium avium; Mycobacterium tuberculosis; Sesquiterpenes

1998
Anti-inflammatory effects of South American Tanacetum vulgare.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Carcinogens; Edema; Female; Flavonoids; Mice; Plant Extracts; Sesquiterpenes; South America; Structure-Activity Relationship; Tetradecanoylphorbol Acetate

1998
Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion.
    Planta medica, 1999, Volume: 65, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Humans; Mice; Sesquiterpenes; Tumor Cells, Cultured

1999
Effect of the chloroform extract of Tanacetum vulgare and one of its active principles, parthenolide, on experimental gastric ulcer in rats.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:2

    Topics: Animals; Chloroform; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Severity of Illness Index; Solvents; Stomach Ulcer; Sulfhydryl Compounds

1999
Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells.
    Biochemical and biophysical research communications, 1999, Aug-27, Volume: 262, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Aorta; Cell Compartmentation; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Interferon-gamma; Lactones; Lipopolysaccharides; Muscle, Smooth, Vascular; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Sesquiterpenes

1999
Rapid extraction and high-performance liquid chromatographic determination of parthenolide in feverfew (Tanacetum parthenium).
    Journal of agricultural and food chemistry, 1999, Volume: 47, Issue:3

    Topics: Chromatography, High Pressure Liquid; Indicators and Reagents; Plant Extracts; Plants, Medicinal; Sesquiterpenes; Tanacetum parthenium

1999
Sesquiterpene lactones with potential use as natural herbicide models (I): trans,trans-germacranolides.
    Journal of agricultural and food chemistry, 1999, Volume: 47, Issue:10

    Topics: Herbicides; Humans; Lactones; Plants, Edible; Sesquiterpenes

1999
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Nov-15, Volume: 163, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Enzyme Activation; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; NF-kappa B; NF-kappaB-Inducing Kinase; Phosphorylation; Protein Serine-Threonine Kinases; Sesquiterpenes; Signal Transduction; Tumor Necrosis Factor-alpha

1999
Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family.
    Biochemical and biophysical research communications, 2000, Jan-07, Volume: 267, Issue:1

    Topics: Acute-Phase Proteins; alpha 1-Antichymotrypsin; Carcinoma, Hepatocellular; Cytokines; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1; Interleukin-6; Liver Neoplasms; NF-kappa B; Oncostatin M; Peptides; Recombinant Fusion Proteins; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured

2000
Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats.
    Journal of ethnopharmacology, 1999, Dec-15, Volume: 68, Issue:1-3

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Body Temperature; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Edema; Female; Foot; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Plant Extracts; Plants, Medicinal; Rats; Sesquiterpenes; Sleep; Tanacetum parthenium; Time Factors

1999
Dexamethasone represses 3,5,3'-triiodothyronine-stimulated expression of intercellular adhesion molecule-1 in the human cell line ECV 304.
    Cell biology and toxicology, 1999, Volume: 15, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cell Line; Dexamethasone; Gene Expression Regulation; Humans; Inflammation; Intercellular Adhesion Molecule-1; Kinetics; Microscopy, Immunoelectron; Sesquiterpenes; Triiodothyronine

1999
Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium.
    Cytokine, 2000, Volume: 12, Issue:3

    Topics: Anti-Inflammatory Agents; Biological Transport; DNA-Binding Proteins; Epithelium; Gene Expression Regulation; Humans; I-kappa B Proteins; Interleukin-8; Lung; NF-kappa B; NF-KappaB Inhibitor alpha; Plants, Medicinal; Promoter Regions, Genetic; RNA, Messenger; Sesquiterpenes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2000
Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:9

    Topics: Animals; Caseins; Cell Line; Cell Nucleus; DNA; DNA-Binding Proteins; Female; Gene Expression Regulation, Developmental; Janus Kinase 2; Lactation; Mammary Glands, Animal; Mice; Milk Proteins; NF-kappa B; NF-kappa B p50 Subunit; Phosphorylation; Phosphotyrosine; Pregnancy; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Sesquiterpenes; STAT5 Transcription Factor; Trans-Activators; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha

2000
Requirement for NF-kappaB in transcriptional activation of monocyte chemotactic protein 1 by Chlamydia pneumoniae in human endothelial cells.
    Infection and immunity, 2000, Volume: 68, Issue:7

    Topics: Arteriosclerosis; Base Sequence; Cells, Cultured; Chemokine CCL2; Chlamydia trachomatis; Chlamydophila pneumoniae; DNA Primers; Endothelium, Vascular; Humans; NF-kappa B; RNA, Messenger; Sesquiterpenes; Signal Transduction; Transcriptional Activation

2000
Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1.
    Biochemical pharmacology, 2000, Aug-15, Volume: 60, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Drug Interactions; Humans; Monocytes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sesquiterpenes; Tetradecanoylphorbol Acetate; Transcriptional Activation

2000
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.
    Oncogene, 2000, Aug-24, Volume: 19, Issue:36

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Northern; Blotting, Western; Breast Neoplasms; Caenorhabditis elegans Proteins; DNA; DNA-Binding Proteins; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Proteins; Inhibitor of Apoptosis Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Paclitaxel; Plants, Medicinal; Protein Binding; Proteins; Repressor Proteins; Sesquiterpenes; Superoxide Dismutase; TNF Receptor-Associated Factor 1; Tumor Cells, Cultured

2000
Expression of intercellular adhesion molecule-1 in C6 glioma cells is up-regulated by thyroid hormone.
    Neuroreport, 2000, Sep-11, Volume: 11, Issue:13

    Topics: Actins; Animals; Blood-Brain Barrier; Cell Division; Dexamethasone; Encephalitis; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Glioma; Intercellular Adhesion Molecule-1; Interleukin-1; Lipopolysaccharides; Models, Animal; Neuroglia; Rats; Sesquiterpenes; Triiodothyronine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation; Vimentin

2000
Intra-specific variability of feverfew: correlations between parthenolide, morphological traits and seed origin.
    Planta medica, 2000, Volume: 66, Issue:7

    Topics: Plants, Medicinal; Seeds; Sesquiterpenes; Species Specificity; Tanacetum parthenium

2000
A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation.
    Planta medica, 2001, Volume: 67, Issue:2

    Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation; I-kappa B Proteins; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Plant Leaves; Plants, Medicinal; Sesquiterpenes

2001
Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.
    Oncogene, 2001, 04-19, Volume: 20, Issue:17

    Topics: Animals; Apoptosis; Breast Neoplasms; Calcimycin; CCAAT-Enhancer-Binding Proteins; Endoplasmic Reticulum; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Ionophores; Mice; NF-kappa B; Sesquiterpenes; Stress, Physiological; Transcription Factor CHOP; Transcription Factors; Transfection; Tumor Cells, Cultured; Tunicamycin

2001
Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by parthenolide, a predominant sesquiterpene lactone in Tanacetum parthenium: involvement of nuclear factor-kappaB.
    Immunology letters, 2001, Jul-02, Volume: 77, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Line; Female; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred DBA; NF-kappa B; Plants, Medicinal; Promoter Regions, Genetic; Sesquiterpenes; Tanacetum parthenium; Transfection

2001
Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts.
    Cellular immunology, 2001, May-01, Volume: 209, Issue:2

    Topics: Anti-Inflammatory Agents; Cell Adhesion; Drug Antagonism; Fibroblasts; Gene Expression; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1; Lactones; Plant Extracts; Plants, Medicinal; Sesquiterpenes; Synovial Membrane; Tanacetum parthenium; Tumor Necrosis Factor-alpha

2001
6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.
    Biochemical pharmacology, 2001, Aug-15, Volume: 62, Issue:4

    Topics: Animals; Apoptosis; Drug Interactions; Minor Histocompatibility Antigens; Nerve Degeneration; NF-kappa B; Oxidative Stress; Oxidopamine; PC12 Cells; Plant Extracts; Protective Agents; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Sesquiterpenes

2001
Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones.
    The Journal of biological chemistry, 2001, Oct-26, Volume: 276, Issue:43

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cysteine; DNA-Binding Proteins; Drug Design; I-kappa B Proteins; Lactones; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Binding; Protein Subunits; Quercetin; Sesquiterpenes; Transcription Factor RelA

2001
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.
    Chemistry & biology, 2001, Volume: 8, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Biotinylation; Edema; HeLa Cells; Humans; I-kappa B Kinase; Luciferases; Mice; Mutation; NF-kappa B; Plants, Medicinal; Protein Serine-Threonine Kinases; Sesquiterpenes; Structure-Activity Relationship; Tanacetum parthenium; Transfection; Tumor Necrosis Factor-alpha

2001
Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector.
    Gene therapy, 2001, Volume: 8, Issue:18

    Topics: Acetylcysteine; Adenoviridae; Antioxidants; Cell Line; Chloramphenicol O-Acetyltransferase; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Intercellular Adhesion Molecule-1; Lung; NF-kappa B; Peptides; Pyrrolidines; RNA, Messenger; Sesquiterpenes; Thiocarbamates; Translocation, Genetic

2001
5-Hydroxytryptamine-inhibiting property of Feverfew: role of parthenolide content.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:12

    Topics: Drug Stability; Gastric Fundus; Ileum; Muscle Contraction; Plant Extracts; Plants, Medicinal; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Antagonists; Sesquiterpenes; Tanacetum parthenium

2000
A new sesquiterpene lactone from Tsoongiodendron odorum Chun.
    Journal of Asian natural products research, 2001, Volume: 3, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Chromatography, Gel; Crystallography, X-Ray; Formazans; Gas Chromatography-Mass Spectrometry; HeLa Cells; HL-60 Cells; Humans; KB Cells; Lactones; Magnetic Resonance Spectroscopy; Magnoliaceae; Models, Molecular; Plant Roots; Sesquiterpenes; Sesquiterpenes, Eudesmane; Terpenes; Tetrazolium Salts

2001
GC determination of parthenolide in feverfew products.
    Die Pharmazie, 2001, Volume: 56, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chromatography, Gas; Chromatography, High Pressure Liquid; Quality Control; Sesquiterpenes; Tablets; Tanacetum parthenium

2001
Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury.
    Shock (Augusta, Ga.), 2002, Volume: 17, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA-Binding Proteins; Hemodynamics; I-kappa B Proteins; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Neutrophil Infiltration; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Wistar; Sesquiterpenes

2002
Enhancement of 1 alpha,25-dihydroxyvitamin D(3)-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-kappa B activity.
    British journal of pharmacology, 2002, Volume: 135, Issue:5

    Topics: Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; HL-60 Cells; Humans; Monocytes; NF-kappa B; Santonin; Sesquiterpenes; Time Factors; Vitamin D

2002
Nuclear factor-kappaB as a molecular target for migraine therapy.
    Annals of neurology, 2002, Volume: 51, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA-Binding Proteins; Dura Mater; I-kappa B Proteins; Macrophages; Male; Migraine Disorders; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroglycerin; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sesquiterpenes; Vasodilator Agents

2002
Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1.
    Biochemical and biophysical research communications, 2002, Apr-12, Volume: 292, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; B-Lymphocytes; Cell Line; DNA; Dose-Response Relationship, Drug; Endothelium, Vascular; Genes, Reporter; Humans; Integrin alpha4beta1; Integrins; Interleukin-4; Janus Kinase 2; Leukocytes; Mice; NF-kappa B; Phosphorylation; Plant Extracts; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Lymphocyte Homing; Sesquiterpenes; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Vascular Cell Adhesion Molecule-1

2002
Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.
    Molecular pharmacology, 2002, Volume: 61, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Apoptosis; Disease Models, Animal; DNA; DNA-Binding Proteins; Endotoxins; Enzyme Activation; Hypertension; I-kappa B Proteins; Lung; Male; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sesquiterpenes; Shock, Septic; Tyrosine

2002
Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13.
    Biochemistry, 2002, Jun-18, Volume: 41, Issue:24

    Topics: 4-Nitrophenylphosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotin; Cations, Divalent; Cations, Monovalent; Cell Line; Enzyme Activation; Enzyme Inhibitors; Fungal Proteins; HeLa Cells; Homeodomain Proteins; Humans; Metals; Mice; NF-kappa B; Phosphoprotein Phosphatases; Saccharomyces cerevisiae Proteins; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid; Sesquiterpenes; Substrate Specificity; Trans-Activators; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vanadates

2002
GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.
    The Journal of biological chemistry, 2002, Oct-11, Volume: 277, Issue:41

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Cycle; DNA Fragmentation; Fenretinide; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Humans; Neoplasms; NF-kappa B; Sesquiterpenes; Transcription Factor CHOP; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured

2002
Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide.
    The Journal of biological chemistry, 2002, Oct-11, Volume: 277, Issue:41

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma, Hepatocellular; Caspases; CCAAT-Enhancer-Binding Proteins; Cell Cycle; Cell Division; Cytochrome c Group; Flow Cytometry; Glutathione; Humans; Membrane Potentials; Oxidative Stress; Sesquiterpenes; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured

2002
The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway.
    The Journal of allergy and clinical immunology, 2002, Volume: 110, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, CD1; B7-1 Antigen; B7-2 Antigen; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; CD40 Antigens; CD83 Antigen; Cell Differentiation; Cells, Cultured; Dendritic Cells; Down-Regulation; Endocytosis; Histocompatibility Antigens Class II; Humans; I-kappa B Proteins; Immunoglobulins; Interleukin-12; Lipopolysaccharides; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Sesquiterpenes; Tumor Necrosis Factor-alpha; Up-Regulation

2002
Variations in parthenolide content and daily dose of feverfew products.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002, Aug-15, Volume: 59, Issue:16

    Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Product Labeling; Quality Control; Sesquiterpenes; Tablets; Tanacetum parthenium

2002
Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis.
    The American journal of pathology, 2002, Volume: 161, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cells, Cultured; Chemokine CCL2; Disease Progression; Gene Expression Regulation; Gliotoxin; Glomerular Mesangium; Glomerulonephritis, IGA; Glomerulonephritis, Membranoproliferative; Humans; Inflammation; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proteinuria; Rats; Sesquiterpenes

2002
The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells.
    Cell death and differentiation, 2002, Volume: 9, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; fas Receptor; Humans; Jurkat Cells; NF-kappa B; Promoter Regions, Genetic; Sesquiterpenes; T-Lymphocytes

2002
Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells.
    Journal of neuroimmunology, 2002, Volume: 132, Issue:1-2

    Topics: Animals; Cells, Cultured; Enzyme Activation; I-kappa B Proteins; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Wistar; Sesquiterpenes; Transcription Factor RelA

2002
JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression.
    The Journal of biological chemistry, 2003, Jan-31, Volume: 278, Issue:5

    Topics: Aggrecans; Animals; Base Sequence; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Collagen Type II; Extracellular Matrix Proteins; Gene Expression Regulation; High Mobility Group Proteins; Humans; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Kinetics; Lectins, C-Type; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Probes; Phosphotyrosine; Proteins; Proteoglycans; Receptors, Interleukin-6; Recombinant Proteins; Sesquiterpenes; Signal Transduction; SOX9 Transcription Factor; Transcription Factors; Transcription, Genetic

2003
The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T.
    European journal of immunology, 2002, Volume: 32, Issue:12

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Down-Regulation; Humans; In Vitro Techniques; Interferon-gamma; Interleukin-2; Interleukin-4; Jurkat Cells; Lymphocyte Activation; NF-kappa B; Plants, Medicinal; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Sesquiterpenes; T-Lymphocytes; Transcription, Genetic

2002
Characterization of the molecular events following impairment of NF-kappaB-driven transcription in neurons.
    Brain research. Molecular brain research, 2002, Dec-30, Volume: 109, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Caspases; Cells, Cultured; Cerebral Cortex; Cytochrome c Group; DNA; DNA-Binding Proteins; Homeostasis; Mitochondria; Neurons; NF-kappa B; Nitriles; Organic Chemicals; Peptides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Precursors; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Replication Protein C; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfones; Transcription, Genetic

2002
Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury. Shock 17(2):127-134, 2002.
    Shock (Augusta, Ga.), 2003, Volume: 19, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; I-kappa B Kinase; Myocardial Reperfusion Injury; Myocardium; NF-kappa B; Protein Serine-Threonine Kinases; Rats; Sesquiterpenes

2003
Parthenolide and its photochemically synthesized 1(10)Z isomer: chemical reactivity and structure-activity relationship studies in human leucocyte chemotaxis.
    Bioorganic & medicinal chemistry, 2003, Apr-03, Volume: 11, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Catalysis; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Indicators and Reagents; Isomerism; Models, Molecular; Molecular Conformation; Photochemistry; Sesquiterpenes; Structure-Activity Relationship

2003
Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation.
    Advances in enzyme regulation, 2003, Volume: 43

    Topics: Androstadienes; Animals; Annexin A5; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butyrates; Caspase 3; Caspases; Cell Cycle; Cell Line, Tumor; Coloring Agents; Deoxyadenosines; DNA Damage; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Genistein; Isoxazoles; Leflunomide; Mice; Models, Biological; Purines; RNA, Messenger; Roscovitine; Sesquiterpenes; Time Factors; Tumor Suppressor Protein p53; Wortmannin

2003
Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis.
    Stroke, 2003, Volume: 34, Issue:7

    Topics: Aged; Animals; Arteriosclerosis; Carotid Artery Diseases; Cells, Cultured; Chemokine CCL2; Cytokines; Electrophoretic Mobility Shift Assay; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Inflammation Mediators; Male; Muscle, Smooth, Vascular; NF-kappa B; Parathyroid Hormone-Related Protein; Peptide Fragments; Peptide Hormones; Precipitin Tests; Proteins; Rats; Receptor, Parathyroid Hormone, Type 1; Receptors, Parathyroid Hormone; RNA, Messenger; Sesquiterpenes

2003
NF-kappaB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: difficulties in identification of dead cells in such cultures.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2003, Volume: 54, Issue:2

    Topics: Acridine Orange; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspases; Cell Membrane; Coloring Agents; DNA; Flow Cytometry; HL-60 Cells; Humans; Immunohistochemistry; Necrosis; NF-kappa B; Propidium; RNA; Sesquiterpenes; Time Factors

2003
Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2003, Volume: 41, Issue:10

    Topics: Animals; Apigenin; Cell Line; Chamomile; Cytokines; Enzyme-Linked Immunosorbent Assay; Flavonoids; Ginsenosides; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Panax; Sesquiterpenes; Tanacetum parthenium; Tumor Necrosis Factor-alpha

2003
Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis.
    Critical care medicine, 2003, Volume: 31, Issue:9

    Topics: Animals; Biopsy, Needle; Disease Models, Animal; Hemodynamics; Immunohistochemistry; Inflammation Mediators; Injections, Intraperitoneal; Male; Multiple Organ Failure; NF-kappa B; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sepsis; Sesquiterpenes; Survival Rate; Treatment Outcome

2003
Nuclear factor-kappaB: is it a therapeutic target for the adjuvant treatment of sepsis?
    Critical care medicine, 2003, Volume: 31, Issue:9

    Topics: Animals; Chemotherapy, Adjuvant; Clinical Trials as Topic; Critical Care; Disease Models, Animal; Female; Humans; Male; Mice; NF-kappa B; Prognosis; Rats; Sepsis; Sesquiterpenes; Severity of Illness Index; Treatment Outcome

2003
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.
    FEBS letters, 2003, Sep-25, Volume: 552, Issue:2-3

    Topics: Animals; Antimalarials; Artemisinins; Base Sequence; Cell Line; Cytokines; DNA, Complementary; Enzyme Inhibitors; Humans; Lipopolysaccharides; Mice; Neuroglia; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sesquiterpenes

2003
Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2003, Volume: 54, Issue:4

    Topics: Animals; Astrocytes; Brain; Brain Chemistry; Cell Culture Techniques; Curcumin; Cytokines; Drug Synergism; Epidermal Growth Factor; Gene Expression Regulation; Inflammation Mediators; Interferon-gamma; Interleukin-1; Matrix Metalloproteinase 3; Mice; NF-kappa B; Pyrrolidines; RNA, Messenger; Sesquiterpenes; Thiocarbamates; Time Factors; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2003
Transport of parthenolide across human intestinal cells (Caco-2).
    Planta medica, 2003, Volume: 69, Issue:11

    Topics: Biological Transport, Active; Caco-2 Cells; Chromatography, High Pressure Liquid; Humans; Intestinal Mucosa; Phytotherapy; Sesquiterpenes; Tanacetum parthenium

2003
NF-kappaB activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability.
    Stroke, 2004, Volume: 35, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carotid Artery Diseases; Caspase 3; Caspases; Cells, Cultured; Cytotoxicity Tests, Immunologic; Fas Ligand Protein; Gene Expression Regulation; Genes, Reporter; Humans; Jurkat Cells; Leukocytes, Mononuclear; Membrane Glycoproteins; Mice; NF-kappa B; RNA, Messenger; Sesquiterpenes; T-Lymphocytes; Transfection

2004
Effect of C-reactive protein on chemokine expression in human aortic endothelial cells.
    Journal of molecular and cellular cardiology, 2004, Volume: 36, Issue:3

    Topics: Aorta; Arteriosclerosis; C-Reactive Protein; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Endothelial Cells; Gene Expression Regulation; Humans; Interleukin-8; NF-kappa B; Peptides; RNA, Messenger; Sesquiterpenes

2004
Native LDL induces interleukin-8 expression via H2O2, p38 Kinase, and activator protein-1 in human aortic smooth muscle cells.
    Cardiovascular research, 2004, Apr-01, Volume: 62, Issue:1

    Topics: Aorta; Caffeic Acids; Cells, Cultured; Coronary Vessels; Dactinomycin; Dose-Response Relationship, Drug; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Interleukin-8; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; Pyridines; Sesquiterpenes; Time Factors; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2004
Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms.
    Carcinogenesis, 2004, Volume: 25, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Celecoxib; Cell Death; Cyclooxygenase 2; Dinoprostone; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Cells; Female; Immunohistochemistry; Isoenzymes; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Hairless; Mitogen-Activated Protein Kinases; Models, Chemical; Neoplasms, Radiation-Induced; p38 Mitogen-Activated Protein Kinases; Papilloma; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrazoles; Sesquiterpenes; Skin Neoplasms; Sulfonamides; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Ultraviolet Rays

2004
[Sbudies on the effect of parthenolide on the proliferation of rat vascular smooth muscle cells and the mechanism].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2003, Volume: 28, Issue:7

    Topics: Animals; Aorta, Thoracic; Asteraceae; Cell Cycle; Cell Division; Cells, Cultured; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Plants, Medicinal; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Sesquiterpenes

2003
Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells.
    Cancer letters, 2004, May-28, Volume: 208, Issue:2

    Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Buthionine Sulfoximine; Calcium; Cell Line, Tumor; Colorectal Neoplasms; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Humans; Oxidation-Reduction; Reactive Oxygen Species; Sesquiterpenes; Sulfhydryl Compounds

2004
NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; I-kappa B Proteins; NF-kappa B; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; Tamoxifen

2004
The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release.
    European journal of immunology, 2004, Volume: 34, Issue:6

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Western; Cell Communication; Cell Survival; Chromones; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; I-kappa B Proteins; Interleukin-8; Morpholines; Neutrophils; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Sulfones; Tumor Necrosis Factor-alpha

2004
Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential.
    Life sciences, 2004, Jul-02, Volume: 75, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Binding Proteins; Cysteine; DNA-Binding Proteins; Ethylmaleimide; HeLa Cells; Humans; I-kappa B Kinase; Jurkat Cells; Macrophages; Membrane Glycoproteins; Mice; Mutation; Nerve Tissue Proteins; NF-kappa B; Protein Serine-Threonine Kinases; Sesquiterpenes; Synaptotagmin I; Synaptotagmins; Transcription Factor RelA; Transcriptional Activation; Transfection

2004
Modulation of inhibitor kappaB kinase/ nuclear factor kappaB signaling during critical illness: a double-edged sword.
    Critical care medicine, 2004, Volume: 32, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Critical Care; Critical Illness; Disease Models, Animal; Humans; Inflammation; Multiple Organ Failure; NF-kappa B; Sepsis; Sesquiterpenes; Signal Transduction

2004
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.
    Cancer letters, 2004, Aug-10, Volume: 211, Issue:2

    Topics: Apoptosis; Caspase 8; Caspases; Colorectal Neoplasms; Genes, bcl-2; Humans; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Signal Transduction; Tanacetum parthenium; Tumor Cells, Cultured; Up-Regulation

2004
Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells.
    Carcinogenesis, 2004, Volume: 25, Issue:11

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; Female; Humans; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; NF-kappa B; Sesquiterpenes; Tumor Necrosis Factor-alpha

2004
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.
    Oncogene, 2004, Sep-23, Volume: 23, Issue:44

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Fibroblasts; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Glycoproteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidative Stress; Sesquiterpenes; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2004
Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:9

    Topics: Androstadienes; Animals; Animals, Newborn; Butadienes; Cardiomegaly; Cell Size; Cells, Cultured; Cytokines; DNA-Binding Proteins; Heart Ventricles; Leucine; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Wortmannin

2004
Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2004, Volume: 19, Issue:11

    Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Western; Bone and Bones; Bone Resorption; Cell Differentiation; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Genes, Reporter; Glycoproteins; Green Fluorescent Proteins; Interleukin-1; Lactones; Lipopolysaccharides; Luciferases; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Confocal; NF-kappa B; Osteoclasts; Osteolysis; Osteoprotegerin; Protein Transport; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Time Factors; TNF Receptor-Associated Factor 6; Transcription, Genetic; Tumor Necrosis Factor-alpha

2004
Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 79, Issue:2

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Carrageenan; Indomethacin; Inflammation; Lactones; Magnolia; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Sesquiterpenes

2004
Microtubule-interfering activity of parthenolide.
    Chemico-biological interactions, 2004, Oct-15, Volume: 149, Issue:2-3

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Colchicine; Cytoskeleton; Dose-Response Relationship, Drug; Female; Humans; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Paclitaxel; Plant Extracts; Sesquiterpenes; Tanacetum parthenium; Tubulin

2004
Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:1

    Topics: Animals; Antiprotozoal Agents; Cell Line; Lactones; Leishmania; Macrophages; Mice; Parasitic Sensitivity Tests; Plant Extracts; Sesquiterpenes; Tanacetum parthenium

2005
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.
    The Journal of experimental medicine, 2005, Jan-03, Volume: 201, Issue:1

    Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Chemokine CCL4; Cytokines; DNA Primers; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Gliotoxin; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophage Inflammatory Proteins; Mice; Mice, Knockout; Mixed Function Oxygenases; Neutrophils; NF-kappa B p50 Subunit; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Polymerase Chain Reaction; Protein Binding; Repressor Proteins; Sesquiterpenes; Transcription Factors

2005
The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Humans; NF-kappa B; Sesquiterpenes

2005
NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Feb-01, Volume: 174, Issue:3

    Topics: Apoptosis; Chlamydia trachomatis; Cycloheximide; Diterpenes; Epithelial Cells; Gene Deletion; HeLa Cells; Humans; Immunity, Innate; NF-kappa B; Sesquiterpenes; Signal Transduction; Staurosporine; Transcription Factor RelA

2005
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
    Blood, 2005, Jun-01, Volume: 105, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blast Crisis; Cells, Cultured; Humans; Lactones; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes; Transplantation, Heterologous; Tumor Stem Cell Assay; Tumor Suppressor Protein p53

2005
Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide.
    Cell death and differentiation, 2005, Volume: 12, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Humans; Jurkat Cells; Oxidative Stress; Sesquiterpenes

2005
A potent apoptosis-inducing activity of a sesquiterpene lactone, arucanolide, in HL60 cells: a crucial role of apoptosis-inducing factor.
    Journal of pharmacological sciences, 2005, Volume: 97, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Asteraceae; Cell Line, Tumor; Flavoproteins; Growth Inhibitors; HL-60 Cells; Humans; Lactones; Membrane Potentials; Membrane Proteins; Mitochondria; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Germacrane

2005
Possible role of NF-kappaB in Bcl-X(L) protection against hydrogen peroxide-induced PC12 cell death.
    Redox report : communications in free radical research, 2004, Volume: 9, Issue:6

    Topics: Animals; Apoptosis; bcl-X Protein; Cell Death; DNA-Binding Proteins; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Oxygenases; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Sesquiterpenes; Tosylphenylalanyl Chloromethyl Ketone; Transfection

2004
Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2005, Volume: 56 Suppl 1

    Topics: Acetylcysteine; Anti-Inflammatory Agents; Cells, Cultured; Curcumin; Diet, Mediterranean; Electrophoretic Mobility Shift Assay; Endothelial Cells; Humans; Interleukin-1; Interleukin-6; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Plant Extracts; Quercetin; Sesquiterpenes; STAT Transcription Factors; Transcription Factor AP-1

2005
Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.
    Cancer research, 2005, Apr-01, Volume: 65, Issue:7

    Topics: Amino Acid Sequence; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Drug Synergism; Fenretinide; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Molecular Sequence Data; Muscle Proteins; NF-kappa B; Nuclear Proteins; Polymerase Chain Reaction; Repressor Proteins; RNA, Messenger; Sesquiterpenes; Up-Regulation

2005
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
    Journal of biochemistry and molecular biology, 2005, Mar-31, Volume: 38, Issue:2

    Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Liver Neoplasms; Membrane Proteins; NF-E2-Related Factor 2; Proteins; Sesquiterpenes; Sulfoxides; Thiocyanates; Trans-Activators; Transcriptional Activation

2005
Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Models, Biological; NF-kappa B; Pancreatic Neoplasms; Phosphorylation; Protein Binding; Sesquiterpenes; Sulindac; Transcription, Genetic; Transfection

2005
Intracellular redox state regulation by parthenolide.
    Biochemical and biophysical research communications, 2005, Jul-01, Volume: 332, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Glutathione; Hippocampus; Homeostasis; Intracellular Fluid; Mice; Neurons; Oxidation-Reduction; Sesquiterpenes

2005
NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis.
    Cell biology international, 2005, Volume: 29, Issue:7

    Topics: Apoptosis; Biological Transport; Cell Line, Tumor; Cell Nucleus; Dimethyl Sulfoxide; Flow Cytometry; Humans; Microscopy, Electron; NF-kappa B; Nitric Oxide Synthase; Nitrites; Sesquiterpenes; Time Factors

2005
Parthenolide and abscisic acid synthesis in feverfew are associated but environmental factors affect them dissimilarly.
    Journal of plant physiology, 2005, Volume: 162, Issue:5

    Topics: Abscisic Acid; Carotenoids; Circadian Rhythm; Flowers; Light; Sesquiterpenes; Tanacetum parthenium; Time Factors; Water

2005
The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:6

    Topics: Adipocytes; Animals; Breast Neoplasms; Cell Death; Cell Line, Tumor; Disease Models, Animal; Docetaxel; Humans; Interferon-gamma; Interleukin-6; Interleukin-8; Lactones; Mice; Mice, Nude; Neoplasm Metastasis; Sesquiterpenes; Survival Rate; Taxoids; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2005
Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.
    The Journal of rheumatology, 2005, Volume: 32, Issue:7

    Topics: ADAM Proteins; ADAMTS4 Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Collagenases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Interleukin-6; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Matrix Metalloproteinases; Metalloendopeptidases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Procollagen N-Endopeptidase; Receptors, Interleukin-6; Sesquiterpenes; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation; Up-Regulation

2005
Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis.
    Cancer research, 2005, Jul-15, Volume: 65, Issue:14

    Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Cytochromes c; Drug Resistance, Neoplasm; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Membrane Potentials; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sesquiterpenes; Tumor Suppressor Protein p53

2005
Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor kappaB inhibitor, parthenolide.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cell Division; Cell Proliferation; Cells, Cultured; Fibroblast Growth Factor 2; Fibroblasts; Genes, Reporter; Humans; Luciferases; Matrix Metalloproteinase 1; Melanocytes; Mice; Mice, Inbred DBA; NF-kappa B; Plasmids; Sesquiterpenes; Skin Aging; Transfection; Ultraviolet Rays

2005
Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine.
    Cephalalgia : an international journal of headache, 2005, Volume: 25, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Immunohistochemistry; Male; Migraine Disorders; Neurons; NF-kappa B; Nitroglycerin; Oncogene Proteins v-fos; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tanacetum parthenium; Vasodilator Agents

2005
Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids.
    The Journal of nutritional biochemistry, 2005, Volume: 16, Issue:8

    Topics: Animals; Arachidonic Acid; Collagen; Eicosapentaenoic Acid; Gene Expression; Gene Expression Profiling; Lipopolysaccharides; Mice; NF-kappa B; Sesquiterpenes; Swiss 3T3 Cells

2005
Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways.
    Carcinogenesis, 2005, Volume: 26, Issue:12

    Topics: Animals; Apoptosis; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis; Genes, Dominant; Mice; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Sesquiterpenes; Signal Transduction; Ultraviolet Rays

2005
Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.
    The Journal of investigative dermatology, 2005, Volume: 125, Issue:3

    Topics: Anti-Bacterial Agents; Cells, Cultured; Chemokine CCL17; Chemokines, CC; ErbB Receptors; Humans; Interferon-gamma; Keratinocytes; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Quinazolines; Roxithromycin; Sesquiterpenes; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha

2005
Feverfew: weeding out the root of leukaemia.
    Expert opinion on biological therapy, 2005, Volume: 5, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; NF-kappa B; Plants, Medicinal; Sesquiterpenes; Tanacetum parthenium; Xenograft Model Antitumor Assays

2005
Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.
    Biochimica et biophysica acta, 2005, Sep-15, Volume: 1736, Issue:2

    Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cell Line; Chemokine CCL2; Down-Regulation; Fatty Acids; Heptanoic Acids; Lipopolysaccharides; Muscle Cells; NF-kappa B; PPAR gamma; PPAR-beta; Protein Binding; Protein Kinases; Pyrroles; Rats; Sesquiterpenes; Transcription Factors; Transcriptional Activation

2005
Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation.
    Endocrinology, 2006, Volume: 147, Issue:1

    Topics: Alkaloids; Animals; Benzophenanthridines; Biological Transport; Cell Line; Enzyme Inhibitors; Glucose; Mice; Muscle, Skeletal; Naphthalenes; NF-kappa B; Palmitic Acid; Phenanthridines; Protein Kinase C; Pyrrolidines; Sesquiterpenes; Thiocarbamates; Tumor Necrosis Factor-alpha

2006
Processing of a sesquiterpene lactone by Papilio glaucus caterpillars.
    Journal of chemical ecology, 2005, Volume: 31, Issue:11

    Topics: Adaptation, Physiological; Animals; Lactones; Larva; Lepidoptera; Magnetic Resonance Spectroscopy; Plant Leaves; Plants, Toxic; Sesquiterpenes

2005
Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:4

    Topics: Animals; CpG Islands; Dinoprostone; DNA; Fever; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Pyrogens; Sesquiterpenes; Signal Transduction; Temperature; Toll-Like Receptors

2006
CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27.
    Experimental dermatology, 2006, Volume: 15, Issue:2

    Topics: Cell Line; Chemokine CCL27; Chemokines; Chemokines, CC; Dermatitis; Humans; Imidazoles; Interleukin-1; Keratinocytes; Ligands; MAP Kinase Signaling System; NF-kappa B; Pyridines; Receptors, CCR10; Receptors, Chemokine; Sesquiterpenes; Signal Transduction; Tumor Necrosis Factor-alpha

2006
[Effects of parthenolide on the activity and expression of urokinase type plasminogen activator in PGCL3 cells].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2005, Volume: 28, Issue:9

    Topics: Actins; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; NF-kappa B; Plants, Medicinal; Sesquiterpenes; Tanacetum; Urokinase-Type Plasminogen Activator

2005
Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo.
    The Journal of endocrinology, 2006, Volume: 188, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Corticosterone; Dehydroepiandrosterone; Estradiol; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; NF-kappa B; Pituitary Neoplasms; Pro-Opiomelanocortin; Repressor Proteins; RNA, Messenger; RNA, Neoplasm; Sesquiterpenes; Survivin; Testosterone; Transcription, Genetic; Tumor Cells, Cultured

2006
Antiproliferative activities of parthenolide and golden feverfew extract against three human cancer cell lines.
    Journal of medicinal food, 2006,Spring, Volume: 9, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Breast Neoplasms; Camphor; Cell Division; Cell Line, Tumor; Drug Synergism; Female; Humans; Luteolin; Neoplasms; Plant Extracts; Sesquiterpenes; Tanacetum parthenium; Uterine Cervical Neoplasms

2006
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro.
    Leukemia, 2006, Volume: 20, Issue:6

    Topics: Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Mitochondria; NF-kappa B; Sesquiterpenes; T-Lymphocytes; Tumor Suppressor Protein p53; Up-Regulation

2006
Contact allergy to herbal teas derived from Asteraceae plants.
    Contact dermatitis, 2006, Volume: 54, Issue:4

    Topics: Adult; Aged; Asteraceae; Case-Control Studies; Dermatitis, Allergic Contact; Female; Humans; Lactones; Male; Middle Aged; Patch Tests; Plant Extracts; Sesquiterpenes; Time Factors

2006
Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation.
    Cancer research, 2006, May-01, Volume: 66, Issue:9

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; bcl-X Protein; Caspase Inhibitors; Caspases; Cell Line, Tumor; Drug Interactions; Etoposide; Female; Melanoma, Experimental; Mice; Mice, Inbred C57BL; NF-kappa B; Platelet Activating Factor; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sesquiterpenes; Up-Regulation

2006
Parthenolide has limited effects on nuclear factor-kappa beta increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice.
    Cytokine, 2006, Mar-21, Volume: 33, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cytokines; Disease Models, Animal; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Sesquiterpenes; Shock, Septic; Signal Transduction; Survival Rate

2006
Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:8

    Topics: Animals; Apoptosis; Atherosclerosis; Cell Division; Cells, Cultured; Dietary Fats; Humans; Inflammation; Mice; NF-kappa B; Sesquiterpenes

2006
Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest.
    Molecular cancer research : MCR, 2006, Volume: 4, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Cyclooxygenase Inhibitors; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Humans; I-kappa B Proteins; Interphase; NF-kappa B; Nitrobenzenes; Sesquiterpenes; Sulfonamides; Transcription, Genetic

2006
Inhibition of DMXAA-induced tumor necrosis factor production in murine splenocyte cultures by NF-kappaB inhibitors.
    Oncology research, 2006, Volume: 16, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cells, Cultured; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Salicylates; Sesquiterpenes; Spleen; Tumor Necrosis Factor-alpha; Xanthones

2006
Estrogen dependent growth inhibitory effects of tamoxifen but not genistein in solid tumors derived from estrogen receptor positive (ER+) primary breast carcinoma MCF7: single agent and novel combined treatment approaches.
    Bulletin du cancer, 2006, Volume: 93, Issue:7

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estradiol; Female; Genistein; Humans; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Sesquiterpenes; Spheroids, Cellular; Tamoxifen; Tretinoin

2006
Quantification of parthenolide in Tanacetum species by LC-UV/LC-MS and microscopic comparison of Mexican/US feverfew samples.
    Die Pharmazie, 2006, Volume: 61, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Calibration; Chromatography, High Pressure Liquid; Mass Spectrometry; Mexico; Microscopy, Fluorescence; Reference Standards; Sesquiterpenes; Spectrophotometry, Ultraviolet; Tanacetum; Tanacetum parthenium; United States

2006
Artemisolide from Artemisia asiatica: nuclear factor-kappaB (NF-kappaB) inhibitor suppressing prostaglandin E2 and nitric oxide production in macrophages.
    Archives of pharmacal research, 2006, Volume: 29, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Artemisia; Cell Line; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Genes, Reporter; Lipopolysaccharides; Macrophages; Mice; NF-kappa B p50 Subunit; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Components, Aerial; Sesquiterpenes; Transcription Factor RelA; Transfection; Triterpenes

2006
Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model.
    The Prostate, 2006, Oct-01, Volume: 66, Issue:14

    Topics: Androgen Antagonists; Anilides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Cell Line, Tumor; Docetaxel; Drug Synergism; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Nitriles; Prostatic Neoplasms; Radionuclide Imaging; Sesquiterpenes; Taxoids; TNF Receptor-Associated Factor 1; TNF Receptor-Associated Factor 2; Tosyl Compounds; Umbilical Veins; Vascular Endothelial Growth Factor A

2006
Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.
    Planta medica, 2006, Volume: 72, Issue:12

    Topics: Aporphines; Atropa belladonna; Atropine; Caffeine; Chemistry Techniques, Analytical; Cola; Flavonoids; Peumus; Pharmacopoeias as Topic; Plant Extracts; Sesquiterpenes; Tanacetum parthenium; Vitex

2006
Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:12

    Topics: Acetylcysteine; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Catalase; Cell Survival; Enzyme Inhibitors; Humans; Multiple Myeloma; Onium Compounds; Oxidative Stress; Reactive Oxygen Species; Sesquiterpenes

2006
[Proliferation inhibiting and apoptosis inducing effects of parthenolide on human multiple myeloma cells].
    Zhonghua yi xue za zhi, 2006, Jul-25, Volume: 86, Issue:28

    Topics: Actihaemyl; Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Humans; Multiple Myeloma; Sesquiterpenes

2006
Parthenolide reduces cisplatin-induced renal damage.
    Toxicology, 2007, Jan-25, Volume: 230, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Cell Nucleus; Cisplatin; Electrophoretic Mobility Shift Assay; Glomerular Filtration Rate; Immunohistochemistry; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Kidney Diseases; Kidney Function Tests; Kidney Medulla; Kidney Tubules; Lipid Peroxidation; Lipid Peroxides; Male; NF-kappa B; Nuclear Proteins; Oxidative Stress; Rats; Rats, Wistar; Sesquiterpenes; Superoxides

2007
Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.
    Cytokine, 2006, Volume: 36, Issue:3-4

    Topics: Antibodies, Monoclonal; Cells, Cultured; Cycloheximide; Cytokines; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Imidazoles; Interleukin-6; Janus Kinase 2; Kinetics; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; STAT3 Transcription Factor; Stilbenes; Tyrphostins; Umbilical Cord

2006
Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jan-01, Volume: 13, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Luciferases; Male; Mice; Mice, Inbred C3H; Neoplasm Metastasis; NF-kappa B; Osteosarcoma; Protein Binding; Sesquiterpenes

2007
Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes.
    Biochimica et biophysica acta, 2007, Volume: 1773, Issue:3

    Topics: ADAM Proteins; ADAMTS4 Protein; Arteries; Cartilage; Cells, Cultured; Chondrocytes; DNA; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Janus Kinases; Matrix Metalloproteinase 13; Oncostatin M; Phosphatidylinositol 3-Kinases; Procollagen N-Endopeptidase; Protein Binding; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; STAT Transcription Factors

2007
Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.
    American journal of respiratory cell and molecular biology, 2007, Volume: 36, Issue:6

    Topics: Active Transport, Cell Nucleus; Animals; Bronchoalveolar Lavage Fluid; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; I-kappa B Kinase; Inflammation; Interleukin-1beta; Interleukin-8; Lipopolysaccharides; Lung; Male; Mice; Mice, Knockout; NF-kappa B; Sesquiterpenes; Tumor Necrosis Factor-alpha

2007
Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes.
    Free radical biology & medicine, 2007, Feb-15, Volume: 42, Issue:4

    Topics: Animals; Enzyme Activation; Glutathione; Membrane Potentials; Mitogen-Activated Protein Kinases; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sesquiterpenes; STAT3 Transcription Factor

2007
Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Feb-15, Volume: 178, Issue:4

    Topics: 3' Untranslated Regions; Androstadienes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell-Free System; Chromones; Female; Gene Expression Regulation; I-kappa B Kinase; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Formyl Peptide; Ribosomal Protein S6 Kinases, 70-kDa; RNA Stability; RNA, Messenger; Sesquiterpenes; Signal Transduction; Toll-Like Receptor 4; TOR Serine-Threonine Kinases; Wortmannin

2007
Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts.
    Immunology letters, 2007, Mar-15, Volume: 109, Issue:1

    Topics: Antibodies; Arthritis, Rheumatoid; Fibroblasts; Humans; Interleukin-15; NF-kappa B; Sesquiterpenes; Synovial Membrane; Toll-Like Receptor 2; Toll-Like Receptor 4; Up-Regulation

2007
Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB.
    International journal of cancer, 2007, Jun-15, Volume: 120, Issue:12

    Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Interleukin-8; Lactones; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; NF-kappa B; Phosphorylation; Sesquiterpenes; Time Factors; Tumor Burden; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2007
Compositae dermatitis from airborne parthenolide.
    The British journal of dermatology, 2007, Volume: 156, Issue:3

    Topics: Adult; Aged; Air Pollutants; Allergens; Dermatitis, Allergic Contact; Environmental Monitoring; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Patch Tests; Sesquiterpenes; Tanacetum parthenium; Volatilization

2007
Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9.
    Cell research, 2007, Volume: 17, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspase 9; Caspase Inhibitors; Cells, Cultured; Enzyme Activation; Epithelial Cells; Humans; Lens, Crystalline; Oxidative Stress; Rabbits; Sesquiterpenes

2007
Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells.
    Life sciences, 2007, Apr-03, Volume: 80, Issue:17

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Sesquiterpenes; Transcription, Genetic; Tumor Necrosis Factor-alpha

2007
TNF-alpha induces transient resistance to Fas-induced apoptosis in eosinophilic acute myeloid leukemia cells.
    Cellular & molecular immunology, 2007, Volume: 4, Issue:1

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Apoptosis; Electrophoretic Mobility Shift Assay; Eosinophils; Fas Ligand Protein; Humans; I-kappa B Kinase; Leukemia, Myeloid; NF-kappa B; Nitriles; Sesquiterpenes; Sulfones; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; X-Linked Inhibitor of Apoptosis Protein

2007
Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS.
    Journal of cellular physiology, 2007, Volume: 212, Issue:2

    Topics: Acetylcysteine; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokine Receptor gp130; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Heart Ventricles; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; Myocytes, Cardiac; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor

2007
Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:1

    Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Blotting, Western; Body Weight; Chemokine CCL2; Collagen; Electrophoretic Mobility Shift Assay; Hypertension, Renal; Kidney; Macrophages; Male; Monocytes; NF-kappa B; Proteinuria; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rho Factor; RNA, Messenger; Sesquiterpenes; Transcription Factor RelA; Transforming Growth Factor beta1; Vasoconstrictor Agents

2007
Parthenolide inhibits tubulin carboxypeptidase activity.
    Cancer research, 2007, Apr-01, Volume: 67, Issue:7

    Topics: Carboxypeptidases; Drug Interactions; HeLa Cells; Humans; NF-kappa B; Paclitaxel; Sesquiterpenes; Structure-Activity Relationship; Tubulin

2007
Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells.
    Cancer letters, 2007, Aug-28, Volume: 254, Issue:1

    Topics: Apoptosis; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Nitric Oxide; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Reactive Oxygen Species; Risk Factors; Sesquiterpenes; Tumor Cells, Cultured

2007
Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cyclin D1; Humans; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Prostaglandin-Endoperoxide Synthases; Sesquiterpenes; Sulindac

2007
Potentiation of arsenic trioxide cytotoxicity by Parthenolide and buthionine sulfoximine in murine and human leukemic cells.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:5

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; DNA Fragmentation; Drug Synergism; Flow Cytometry; Glutamate-Cysteine Ligase; Glutathione; Humans; Leukemia; Mice; Microscopy, Fluorescence; NF-kappa B; Oxides; Reactive Oxygen Species; Sesquiterpenes

2008
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated.
    Chemistry & biology, 2007, Volume: 14, Issue:7

    Topics: Acetylation; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Histone Deacetylases; Histones; Humans; Hydrolysis; Phosphatidylinositol 3-Kinases; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2007
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
    Blood, 2007, Dec-15, Volume: 110, Issue:13

    Topics: Animals; Biological Availability; Dogs; Drug Design; Humans; Leukemia, Myeloid, Acute; Mice; Neoplastic Stem Cells; NF-kappa B; Oxidative Stress; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2007
The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:9

    Topics: Blotting, Western; Electrophoretic Mobility Shift Assay; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Male; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Radiation Tolerance; Sesquiterpenes; Signal Transduction; Superoxide Dismutase; Tumor Cells, Cultured

2007
Trypanosoma cruzi: antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms.
    Experimental parasitology, 2008, Volume: 118, Issue:3

    Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Hemolysis; Inhibitory Concentration 50; Macaca mulatta; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Plant Extracts; Sesquiterpenes; Tanacetum parthenium; Trypanosoma cruzi

2008
NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells.
    Breast cancer research and treatment, 2008, Volume: 111, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Female; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; NF-kappa B; Paclitaxel; Pyrrolidines; Sesquiterpenes; Spheroids, Cellular; Thiocarbamates; Time Factors; Xenograft Model Antitumor Assays

2008
Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:4

    Topics: Alkanes; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Cytokines; Humans; Hydrocarbons; Imidazoles; Interleukin-10; Irritants; Keratinocytes; NF-kappa B; Protein Kinase Inhibitors; Pyridines; Recombinant Proteins; Sesquiterpenes; Substance P; Time Factors

2008
The lipophilic hapten parthenolide induces interferon-gamma and interleukin-13 production by peripheral blood-derived CD8+ T cells from contact allergic subjects in vitro.
    The British journal of dermatology, 2008, Volume: 158, Issue:1

    Topics: Adult; CD8-Positive T-Lymphocytes; Cells, Cultured; Dermatitis, Allergic Contact; Dose-Response Relationship, Immunologic; Enzyme-Linked Immunosorbent Assay; Female; Haptens; Humans; Immunophenotyping; Interferon-gamma; Interleukin-13; Lymphocyte Activation; Male; Middle Aged; Patch Tests; Sesquiterpenes

2008
Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression.
    Archives of dermatological research, 2008, Volume: 300, Issue:2

    Topics: Administration, Topical; Animals; Case-Control Studies; Cells, Cultured; DNA Repair; Environmental Exposure; Erythema; Female; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hyperplasia; Inflammation; Male; Mice; Mice, Hairless; Plant Extracts; Reactive Oxygen Species; Sesquiterpenes; Skin; Skin Aging; Smoking; Swine; Tanacetum parthenium; Ultraviolet Rays

2008
Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair.
    Radiation research, 2007, Volume: 168, Issue:6

    Topics: Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Humans; NF-kappa B; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Tubulin; Tumor Suppressor Protein p53; X-Rays

2007
The solution and solid state stability and excipient compatibility of parthenolide in feverfew.
    AAPS PharmSciTech, 2007, Dec-14, Volume: 8, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Compounding; Drug Stability; Drug Storage; Excipients; Humidity; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Plant Preparations; Powders; Sesquiterpenes; Solutions; Tanacetum parthenium; Technology, Pharmaceutical; Temperature; Water

2007
Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:2

    Topics: Algorithms; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hyperkinesis; Mass Spectrometry; Motor Activity; Planarians; Santonin; Sesquiterpenes; Sesquiterpenes, Eudesmane; Spectrometry, Mass, Electrospray Ionization

2008
Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cocaine; Planarians; Sesquiterpenes; Stereotyped Behavior; Substance Withdrawal Syndrome

2008
Parthenolide induces apoptosis in glioblastomas without affecting NF-kappaB.
    Journal of pharmacological sciences, 2008, Volume: 106, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Glioblastoma; Humans; NF-kappa B; Sesquiterpenes

2008
Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.
    Biochemical and biophysical research communications, 2008, Apr-18, Volume: 368, Issue:4

    Topics: Animals; Antioxidants; Asteraceae; Enhancer Elements, Genetic; Genes, Reporter; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; Lactones; NF-E2-Related Factor 2; PC12 Cells; Rats; Response Elements; Sesquiterpenes

2008
Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
    Blood, 2008, Jun-15, Volume: 111, Issue:12

    Topics: Aldehydes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Death; Cysteine Proteinase Inhibitors; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Models, Genetic; Neoplastic Stem Cells; Oligonucleotide Array Sequence Analysis; Pentacyclic Triterpenes; Sesquiterpenes; Terpenes; Triterpenes; Xenograft Model Antitumor Assays

2008
Antimyeloma effects of a sesquiterpene lactone parthenolide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Mar-15, Volume: 14, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Insulin-Like Growth Factor I; Interleukin-6; Lactones; Leukocytes; Multiple Myeloma; NF-kappa B; Sesquiterpenes; Tumor Necrosis Factor-alpha

2008
Thermosensitization by parthenolide in human lung adenocarcinoma A549 cells and p53- and hsp72-independent apoptosis induction via the nuclear factor-kappaB signal pathway.
    International journal of molecular medicine, 2008, Volume: 21, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Hot Temperature; HSP72 Heat-Shock Proteins; Humans; Lung Neoplasms; NF-kappa B; Sesquiterpenes; Signal Transduction; Tumor Suppressor Protein p53

2008
Inhibitory effects of parthenolide on antigen-induced microtubule formation and degranulation in mast cells.
    International immunopharmacology, 2008, Volume: 8, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Cell Line; Cells, Cultured; I-kappa B Kinase; Immunoglobulin E; Mast Cells; Mice; Mice, Inbred C57BL; Microtubules; NF-kappa B; Nocodazole; Passive Cutaneous Anaphylaxis; Receptors, IgE; Sesquiterpenes; Tubulin Modulators

2008
A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes.
    Journal of controlled release : official journal of the Controlled Release Society, 2008, Jul-02, Volume: 129, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Compounding; Female; Humans; Lipids; Liposomes; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Sesquiterpenes; Technology, Pharmaceutical; Time Factors; Vinblastine; Vinorelbine; Xenograft Model Antitumor Assays

2008
Screening biomaterials for stimulation of nitric oxide-mediated inflammation.
    Journal of biomedical materials research. Part A, 2009, Volume: 90, Issue:1

    Topics: 2-Naphthylamine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Materials; Cell Line; Humans; Hyaluronic Acid; Inflammation; Interferon-gamma; Lipopolysaccharides; Macrophages; Materials Testing; Mice; Nitric Oxide; Nitrites; Sesquiterpenes

2009
Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.
    Genome biology, 2008, Volume: 9, Issue:5

    Topics: Aged; Extracellular Matrix; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Male; Microarray Analysis; Middle Aged; Neoplastic Stem Cells; NF-kappa B; Prostate; Prostatic Neoplasms; Sesquiterpenes

2008
Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2008, Volume: 29, Issue:2

    Topics: Androgens; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Kallikreins; MAP Kinase Kinase Kinases; NF-kappa B; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Prostate-Specific Antigen; Proto-Oncogene Proteins c-myc; Receptors, Androgen; Serine Endopeptidases; Sesquiterpenes; Signal Transduction; Transcriptional Activation

2008
Parthenolide inhibits proliferation of fibroblast-like synoviocytes in vitro.
    Inflammation, 2008, Volume: 31, Issue:4

    Topics: Animals; Arthritis, Rheumatoid; Bromodeoxyuridine; Cell Line; Cell Proliferation; Fibroblasts; Humans; Hyperplasia; Phytotherapy; Rabbits; Sesquiterpenes; Synovial Membrane; Tanacetum parthenium; Tetrazolium Salts; Thiazoles

2008
Antileukemic activity of aminoparthenolide analogs.
    Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14

    Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Lymphoma, Large-Cell, Anaplastic; Models, Chemical; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sesquiterpenes

2008
[Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes].
    Zhonghua yi xue za zhi, 2008, Mar-18, Volume: 88, Issue:11

    Topics: Aggrecans; Arthroplasty, Replacement, Knee; Cells, Cultured; Chondrocytes; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Femur; Glycosaminoglycans; Humans; Isoenzymes; Osteoarthritis; Postoperative Period; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Spectrophotometry; Tumor Necrosis Factor-alpha

2008
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.
    Rheumatology (Oxford, England), 2008, Volume: 47, Issue:11

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Blotting, Western; Cell Proliferation; Cells, Cultured; Fibroblasts; Flavonoids; Humans; Immunohistochemistry; Interleukin-17; Interleukin-1beta; Interleukin-6; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Interleukin-6; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Stimulation, Chemical; Synovial Membrane; Tumor Necrosis Factor-alpha

2008
Inhibitory effects of parthenolide on the angiogenesis induced by human multiple myeloma cells and the mechanism.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2008, Volume: 28, Issue:5

    Topics: Cell Line, Tumor; Endothelial Cells; Humans; Interleukin-6; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Multiple Myeloma; Neovascularization, Pathologic; NF-kappa B; RNA, Messenger; Sesquiterpenes; Umbilical Veins; Vascular Endothelial Growth Factor A

2008
Depressant-like effects of parthenolide in a rodent behavioural antidepressant test battery.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:12

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Maze Learning; Mice; Motor Activity; Olfactory Bulb; Rats; Rats, Wistar; Serotonin Antagonists; Sesquiterpenes; Social Behavior; Swimming

2008
Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis.
    Parasitology research, 2009, Volume: 104, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Clonorchis sinensis; Cyclooxygenase 2; Drug Resistance; Helminth Proteins; Humans; Sesquiterpenes

2009
JP-8 induces immune suppression via a reactive oxygen species NF-kappabeta-dependent mechanism.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 108, Issue:1

    Topics: Administration, Cutaneous; Analysis of Variance; Animals; Carrier Proteins; Cell Line; Cyclooxygenase 2; Female; Gene Expression; Hydrocarbons; Immune Tolerance; Mice; Neoplasm Proteins; NF-kappa B; Reactive Oxygen Species; RNA, Small Interfering; Sesquiterpenes; Superoxide Dismutase; Transcription Factor RelA

2009
Tanacetum vulgare: antiherpes virus activity of crude extract and the purified compound parthenolide.
    Phytotherapy research : PTR, 2009, Volume: 23, Issue:6

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Herpesvirus 1, Human; Molecular Structure; Plant Extracts; Sesquiterpenes; Tanacetum; Vero Cells

2009
Cardiotrophin-1 induces intercellular adhesion molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells.
    Chinese medical journal, 2008, Dec-20, Volume: 121, Issue:24

    Topics: Anthracenes; Butadienes; Cells, Cultured; Cytokines; Electrophoretic Mobility Shift Assay; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gene Expression; Humans; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Sesquiterpenes; Umbilical Veins

2008
Modulation of DNA methylation by a sesquiterpene lactone parthenolide.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:2

    Topics: Alkylation; Animals; Antineoplastic Agents; Apoptosis; Catalytic Domain; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Cysteine; Cytokines; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electrophoretic Mobility Shift Assay; Female; Humans; Immunoblotting; Lactones; Mice; Mice, Nude; Models, Molecular; Neoplasms; Promoter Regions, Genetic; Sesquiterpenes; Sp1 Transcription Factor; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2009
Cytotoxic effects of catechol to neuroblastoma N2a cells.
    General physiology and biophysics, 2008, Volume: 27, Issue:4

    Topics: Animals; Antioxidants; Apoptosis; Ascorbic Acid; Catechols; Cell Line, Tumor; Cell Survival; Curcumin; Cysteine; Cytotoxins; Deferoxamine; Glutathione; Mice; Neuroblastoma; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes; Superoxide Dismutase

2008
Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach.
    The Prostate, 2009, Jun-01, Volume: 69, Issue:8

    Topics: Animals; Antigens, CD; Cell Line, Tumor; Flow Cytometry; Gene Expression Profiling; Humans; Hyaluronan Receptors; Male; Mice; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Prostate; Prostatic Neoplasms; RNA, Neoplasm; Sesquiterpenes; Transcription, Genetic

2009
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
    Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:11

    Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin

2008
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells.
    Molecular endocrinology (Baltimore, Md.), 2009, Volume: 23, Issue:5

    Topics: Adipose Tissue; Anti-Inflammatory Agents, Non-Steroidal; Aromatase; Cell Line, Tumor; Cell Shape; Cell Survival; Cells, Cultured; Chromatin Immunoprecipitation; Estrogens; Flow Cytometry; Gene Expression Regulation, Enzymologic; Genetic Vectors; Humans; I-kappa B Kinase; Immunoblotting; Lentivirus; Nitriles; Promoter Regions, Genetic; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sesquiterpenes; Stromal Cells; Sulfones

2009
Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives.
    Bioorganic & medicinal chemistry letters, 2009, Apr-01, Volume: 19, Issue:7

    Topics: 4-Butyrolactone; Cell Line; Cyclobutanes; Down-Regulation; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase 9; NF-kappa B; Sesquiterpenes; Transcription, Genetic

2009
Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:3

    Topics: Antineoplastic Agents; Cell Proliferation; HCT116 Cells; Histone Deacetylase 1; Histone Deacetylases; Humans; Imidazoles; Models, Biological; Piperazines; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-mdm2; Sesquiterpenes; Transcription, Genetic; Tumor Suppressor Protein p53; Ubiquitination; Up-Regulation

2009
Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.
    British journal of pharmacology, 2009, Volume: 156, Issue:7

    Topics: Antimalarials; Antimetabolites, Antineoplastic; Artemisinins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colonic Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Phosphorylation; Protein Transport; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sesquiterpenes

2009
Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation.
    The Journal of urology, 2009, Volume: 181, Issue:5

    Topics: Analysis of Variance; Animals; Biopsy, Needle; Cyclophosphamide; Cystitis; Disease Models, Animal; Female; Immunohistochemistry; Male; NF-kappa B; Phosphorylation; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sesquiterpenes; Urinary Bladder, Overactive

2009
A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.
    Pancreas, 2009, Volume: 38, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Growth Inhibitors; Humans; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Oxides; Pancreatic Neoplasms; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays

2009
Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells.
    Radiation research, 2009, Volume: 171, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Radiation; Humans; Male; Models, Biological; NF-kappa B; Prostatic Neoplasms; Radiation Tolerance; RNA, Small Interfering; Sesquiterpenes; Transcription Factor RelA; Tumor Suppressor Protein p53; X-Rays

2009
CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.
    Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Movement; Cells, Cultured; Chemokines; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Epithelial Cells; Inflammation; Kidney Tubules; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Sesquiterpenes; Signal Transduction; T-Lymphocytes

2009
Nuclear factor-[kappa]B inhibition provides additional protection against ischaemia/reperfusion injury in delayed sevoflurane preconditioning.
    European journal of anaesthesiology, 2009, Volume: 26, Issue:6

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Clinical Protocols; Ischemic Preconditioning, Myocardial; Male; Methyl Ethers; Myocardial Reperfusion Injury; NF-kappa B; Random Allocation; Rats; Rats, Inbred F344; Sesquiterpenes; Sevoflurane; Ventricular Function, Left; Ventricular Function, Right

2009
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
    Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

    Topics: Animals; Antineoplastic Agents; Cell Death; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Myeloid, Acute; Models, Chemical; NF-kappa B; Rats; Sesquiterpenes; Solubility; Water

2009
Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo.
    Molecular cancer research : MCR, 2009, Volume: 7, Issue:7

    Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Survival; Cytochromes c; Drug Synergism; Histocytochemistry; I-kappa B Kinase; Kaplan-Meier Estimate; Lung Neoplasms; Mice; Mitochondrial Membranes; NF-kappa B; Paclitaxel; Sesquiterpenes; Xenograft Model Antitumor Assays

2009
Parthenolide inhibits proliferation of vascular smooth muscle cells through induction of G0/G1 phase cell cycle arrest.
    Journal of Zhejiang University. Science. B, 2009, Volume: 10, Issue:7

    Topics: Animals; Cell Proliferation; Cells, Cultured; G1 Phase; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Resting Phase, Cell Cycle; Sesquiterpenes

2009
NF-kappaB regulates androgen receptor expression and prostate cancer growth.
    The American journal of pathology, 2009, Volume: 175, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; NF-kappa B; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Sesquiterpenes; Transcription Factor RelA; Xenograft Model Antitumor Assays

2009
Effect of parthenolide on proliferation and apoptosis in gastric cancer cell line SGC7901.
    Journal of digestive diseases, 2009, Volume: 10, Issue:3

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Humans; NF-kappa B; Sesquiterpenes; Stomach Neoplasms

2009
Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis.
    Planta medica, 2010, Volume: 76, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Lactones; Lung Neoplasms; NF-kappa B; Organoplatinum Compounds; Oxaliplatin; Phytotherapy; Plant Extracts; Sesquiterpenes; Tanacetum

2010
[Parthenolide inhibits neuroinflammation and promotes neurogenesis in the ischemic striatum following transient middle cerebral artery occlusion in the adult rat brain].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2009, Volume: 25, Issue:11

    Topics: Animals; Bromodeoxyuridine; Doublecortin Protein; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Inflammation; Ischemia; Male; Neostriatum; Neurogenesis; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tumor Necrosis Factor-alpha

2009
IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways.
    Immunology letters, 2010, Jan-04, Volume: 127, Issue:2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Cell Differentiation; Female; Fibroblasts; Gene Expression Regulation; Humans; Interleukin-23; Male; Middle Aged; NF-kappa B; Osteoarthritis; Osteoclasts; RANK Ligand; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Synovial Membrane; Tyrphostins

2010
Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro.
    Melanoma research, 2010, Volume: 20, Issue:1

    Topics: Acetylcysteine; Adult; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Drug Interactions; Female; Flow Cytometry; Humans; Male; Melanoma; Membrane Potential, Mitochondrial; Mice; Middle Aged; Reactive Oxygen Species; Sesquiterpenes; Skin Neoplasms; Tanacetum parthenium

2010
Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.
    PloS one, 2009, Dec-02, Volume: 4, Issue:12

    Topics: Antioxidants; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Activation; Extracellular Space; Flow Cytometry; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Lymphoma; NF-kappa B; Sesquiterpenes; Sulfhydryl Compounds; Thioredoxins

2009
Inhibition of NF-kappaB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell cycle arrest in human lung adenocarcinoma cells.
    International journal of molecular medicine, 2010, Volume: 25, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Combined Modality Therapy; Humans; Hyperthermia, Induced; Lung Neoplasms; NF-kappa B; Sesquiterpenes

2010
Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator.
    The Journal of biological chemistry, 2010, Mar-05, Volume: 285, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Liver Neoplasms; Mice; Mice, Knockout; MicroRNAs; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; RNA, Small Interfering; Sesquiterpenes; Trans-Activators; Transcription Factors; Transcription, Genetic; Viral Regulatory and Accessory Proteins

2010
Ghrelin decreases microvascular leak during inflammation.
    The Journal of trauma, 2010, Volume: 68, Issue:5

    Topics: Animals; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Ghrelin; Lipopolysaccharides; Mesentery; NF-kappa B; Obesity; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Sesquiterpenes; Signal Transduction; Substance P; Systemic Inflammatory Response Syndrome; Venules; Wounds and Injuries

2010
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
    The Journal of biological chemistry, 2010, Mar-26, Volume: 285, Issue:13

    Topics: Animals; Anti-Inflammatory Agents; Bone Marrow Cells; Caspase 1; Cell Death; Humans; Immunoblotting; Inflammation; L-Lactate Dehydrogenase; Macrophages; Mice; NF-kappa B; Nitriles; Sesquiterpenes; Sulfones

2010
In vivo analysis of gut function and disease changes in a zebrafish larvae model of inflammatory bowel disease: a feasibility study.
    Inflammatory bowel diseases, 2010, Volume: 16, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Embryo, Nonmammalian; Feasibility Studies; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Intestinal Mucosa; Larva; Mesalamine; Prednisolone; Sesquiterpenes; Thalidomide; Zebrafish

2010
Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.
    Journal of neuroimmunology, 2010, Apr-15, Volume: 221, Issue:1-2

    Topics: Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cells, Cultured; Cytokines; Embryonic Stem Cells; Epidermal Growth Factor; Erythropoietin; Fetus; Fibroblast Growth Factor 2; Flow Cytometry; Gene Expression Regulation, Developmental; Histocompatibility Antigens; Humans; Immunosuppressive Agents; Nerve Tissue Proteins; Neurites; Neurons; Sesquiterpenes; Wortmannin

2010
A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells.
    Cancer research, 2010, Apr-01, Volume: 70, Issue:7

    Topics: Catalase; Cell Line, Tumor; Enzyme Activation; Forkhead Box Protein O3; Forkhead Transcription Factors; Glutathione; Humans; Male; NADPH Oxidases; Oncogene Protein v-akt; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Radiation-Sensitizing Agents; Sesquiterpenes; Signal Transduction; Superoxide Dismutase; Thioredoxins

2010
[Effect of parthenolide on leukemia K562 cells and its leukemia stem cells].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:2

    Topics: Apoptosis; Cell Proliferation; Humans; K562 Cells; Leukemia; Neoplastic Stem Cells; Plant Extracts; Sesquiterpenes

2010
Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.
    Microbes and infection, 2010, Volume: 12, Issue:8-9

    Topics: Carrier Proteins; Caspase 1; Cell Line; Chlamydia muridarum; Chlamydia trachomatis; Enzyme Inhibitors; Humans; Interleukin-1beta; Monocytes; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; Sesquiterpenes; Sulfones

2010
Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons.
    American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:3

    Topics: Angiotensin II; Animals; Cell Line; DNA; ets-Domain Protein Elk-1; Mice; Neurons; NF-kappa B; Protein Binding; Receptor, Angiotensin, Type 1; RNA, Small Interfering; Sesquiterpenes; Transcription Factor RelA; Transcription, Genetic; Up-Regulation

2010
Paclitaxel efficacy is increased by parthenolide via nuclear factor-kappaB pathways in in vitro and in vivo human non-small cell lung cancer models.
    Current cancer drug targets, 2010, Volume: 10, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; Cell Survival; Drug Synergism; Humans; I-kappa B Proteins; Lung Neoplasms; Mice; Mice, Nude; NF-kappa B; Paclitaxel; Phosphorylation; Protein Transport; Random Allocation; Sesquiterpenes; Survival Analysis; Xenograft Model Antitumor Assays

2010
Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.
    Natural product research, 2010, Volume: 24, Issue:12

    Topics: Anti-Inflammatory Agents; Curcumin; Cytokines; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Resveratrol; Sesquiterpenes; Stilbenes; Tumor Necrosis Factor-alpha

2010
Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells.
    British journal of pharmacology, 2010, Volume: 160, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Drug Screening Assays, Antitumor; Humans; Melanoma; Neoplasm Metastasis; Neoplasm Proteins; NF-kappa B; Sesquiterpenes

2010
Effects of nuclear factor-κB inhibitors on colon anastomotic healing in rats.
    The Journal of surgical research, 2011, Volume: 171, Issue:1

    Topics: Anastomosis, Surgical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Enteritis; Hydroxyproline; Interleukin-6; Laparotomy; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Animal; NF-kappa B; Rats; Rats, Wistar; Resveratrol; Sesquiterpenes; Stilbenes; Wound Healing

2011
NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.
    Molecular cancer, 2010, Jul-09, Volume: 9

    Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Base Sequence; Betulinic Acid; Blotting, Western; Cell Line, Tumor; DNA Primers; Docetaxel; Estradiol; Flow Cytometry; Humans; Immunohistochemistry; Male; Mitosis; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Sesquiterpenes; Taxoids; Triterpenes

2010
Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Cell Differentiation; Cell Survival; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Humans; I-kappa B Kinase; Imidazoles; Inhibitory Concentration 50; Mice; Osteoclasts; Ovariectomy; Pentacyclic Triterpenes; Quinoxalines; Sesquiterpenes; Signal Transduction; Triterpenes

2010
A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species.
    International journal of cancer, 2011, May-15, Volume: 128, Issue:10

    Topics: Animals; Base Sequence; Carcinogens; Cell Cycle; Cell Division; DNA Primers; Electrophoretic Mobility Shift Assay; Flow Cytometry; Lung Neoplasms; Male; Mice; Mice, Nude; NF-kappa B; Nicotiana; Nitrosamines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sesquiterpenes; Urinary Bladder Neoplasms

2011
Patch test reactivity to feverfew-containing creams in feverfew-allergic patients.
    Contact dermatitis, 2010, Volume: 63, Issue:3

    Topics: Adult; Aged; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Ointments; Patch Tests; Plant Extracts; Sesquiterpenes; Tanacetum parthenium

2010
Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro.
    Journal of experimental & clinical cancer research : CR, 2010, Aug-10, Volume: 29

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caspase 3; Cell Proliferation; Flow Cytometry; Humans; Immunoenzyme Techniques; In Vitro Techniques; Neoplasm Invasiveness; NF-kappa B; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Tumor Cells, Cultured

2010
Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Flow Cytometry; Glutathione; Humans; Leukemia, Myeloid, Acute; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Neoplastic Stem Cells; Peroxidase; Reactive Oxygen Species; RNA, Small Interfering; Sesquiterpenes; Transfection; Xenograft Model Antitumor Assays

2010
The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.
    British journal of haematology, 2010, Volume: 151, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Activation; Histone Deacetylase Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid, Acute; NF-kappa B; Sesquiterpenes; Signal Transduction; Tumor Cells, Cultured

2010
MTA1 coregulator regulates LPS response via MyD88-dependent signaling.
    The Journal of biological chemistry, 2010, Oct-22, Volume: 285, Issue:43

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cytokines; Gene Expression Regulation; Inflammation Mediators; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Myeloid Differentiation Factor 88; Repressor Proteins; Response Elements; Sesquiterpenes; Signal Transduction; Trans-Activators; Transcription Factor RelA; Transcription Factors; Transcription, Genetic

2010
Suppression of intracellular calcium levels and inhibition of degranulation in RBL-2H3 mast cells by the sesquiterpene lactone parthenolide.
    Planta medica, 2011, Volume: 77, Issue:3

    Topics: Animals; Antigens; Calcium; Cell Degranulation; Cell Line, Tumor; Immunologic Factors; Inhibitory Concentration 50; Ionomycin; Mast Cells; Plant Extracts; Rats; Sesquiterpenes; Tanacetum

2011
Molecular pathways of spontaneous and TNF-{alpha}-mediated neutrophil apoptosis under intermittent hypoxia.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Hypoxia; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Female; Gene Expression Regulation; Gliotoxin; Humans; Imidazoles; Immunosuppressive Agents; Interleukin-8; Male; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Interleukin-8B; Receptors, Tumor Necrosis Factor, Type II; Sesquiterpenes; Tumor Necrosis Factor-alpha

2011
Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11).
    International journal of oncology, 2010, Volume: 37, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Separation; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Flow Cytometry; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sesquiterpenes; Signal Transduction; Translocation, Genetic

2010
Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.
    Blood, 2010, Dec-23, Volume: 116, Issue:26

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Blotting, Western; Bone Marrow; Cell Proliferation; Cells, Cultured; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Gene Expression Profiling; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases

2010
Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells.
    Experimental & molecular medicine, 2010, Nov-30, Volume: 42, Issue:11

    Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cholangiocarcinoma; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Heme Oxygenase-1; Humans; Lactones; NF-E2-Related Factor 2; Protein Kinase C-alpha; RNA, Small Interfering; Sesquiterpenes; Signal Transduction

2010
Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Dec-15, Volume: 18, Issue:1

    Topics: Cell Culture Techniques; Drug Synergism; Herb-Drug Interactions; Inhibitory Concentration 50; Nitroimidazoles; Plant Leaves; Sesquiterpenes; Trypanocidal Agents; Trypanosoma cruzi

2010
NFκB inhibitors induce cell death in glioblastomas.
    Biochemical pharmacology, 2011, Feb-01, Volume: 81, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Astrocytes; Brain Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Cisplatin; Curcumin; Doxorubicin; Drug Synergism; Glioblastoma; Humans; Leupeptins; Molecular Targeted Therapy; NF-kappa B; Nitriles; Oxides; Rats; Sesquiterpenes; Signal Transduction; Sulfones

2011
Glyceroneogenesis is inhibited through HIV protease inhibitor-induced inflammation in human subcutaneous but not visceral adipose tissue.
    Journal of lipid research, 2011, Volume: 52, Issue:2

    Topics: Adult; Atazanavir Sulfate; Carrier Proteins; Female; Gene Expression; HIV Protease Inhibitors; Humans; Inflammation; Interleukin-6; Intra-Abdominal Fat; Lopinavir; Male; Nelfinavir; Oligopeptides; Perilipin-1; Phosphoenolpyruvate Carboxykinase (GTP); Phosphoproteins; Pyridines; Pyrimidinones; Ritonavir; Sesquiterpenes; Subcutaneous Fat; Triglycerides; Tumor Necrosis Factor-alpha

2011
Screening for Compositae sensitization with pure allergens: implications of molecular structure, strength of reaction, and time of testing.
    Contact dermatitis, 2011, Volume: 64, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Asteraceae; Child; Dermatitis, Allergic Contact; Female; Humans; Lactones; Male; Middle Aged; Patch Tests; Prevalence; Sesquiterpenes; Young Adult

2011
In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: an approach to their mechanisms of action.
    Phytotherapy research : PTR, 2011, Volume: 25, Issue:2

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Herpesvirus 1, Human; Herpesvirus 2, Human; Plant Extracts; Sesquiterpenes; Tanacetum; Vero Cells

2011
Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity.
    Journal of molecular and cellular cardiology, 2011, Volume: 50, Issue:4

    Topics: Angiotensin II; Animals; Blotting, Western; Echocardiography; Electrophoretic Mobility Shift Assay; Fibroblasts; Hemodynamics; Hypertrophy, Left Ventricular; Immunohistochemistry; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor

2011
The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition.
    Thrombosis research, 2011, Volume: 127, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cell Line; Humans; Megakaryocyte Progenitor Cells; Mice; Mice, Inbred C57BL; NF-kappa B; Platelet Activation; Sesquiterpenes; Tanacetum parthenium

2011
Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cells.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:3

    Topics: Angiotensinogen; Binding Sites; Blotting, Western; Cells, Cultured; Cloning, Organism; Humans; Kidney Tubules, Proximal; NF-kappa B; Promoter Regions, Genetic; Sesquiterpenes

2011
Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4

    Topics: Androgens; Animals; Blood Pressure; Dihydrotestosterone; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; I-kappa B Kinase; Rats; Rats, Sprague-Dawley; Renal Artery; Sesquiterpenes; Vasoconstriction

2011
The NFĸB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011, Volume: 27, Issue:1

    Topics: Aniline Compounds; Annexin A5; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Cell Size; Erythrocytes; Glutathione; Humans; I-kappa B Kinase; NF-kappa B; Nitriles; Phosphatidylserines; Protein Binding; Sesquiterpenes; Signal Transduction; Sulfones; Xanthenes

2011
Parthenolide inhibits TRIF-dependent signaling pathway of Toll-like receptors in RAW264.7 macrophages.
    Molecules and cells, 2011, Volume: 31, Issue:3

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Chemokine CXCL10; Interferon Regulatory Factor-3; Lipopolysaccharides; Luciferases; Macrophages; Mice; NF-kappa B; Peptide Fragments; Poly I-C; Sesquiterpenes; Signal Transduction; Toll-Like Receptors

2011
Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation.
    Journal of cellular physiology, 2011, Volume: 226, Issue:6

    Topics: Apoptosis; Carcinoma, Hepatocellular; Caspases; Down-Regulation; Drug Screening Assays, Antitumor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Janus Kinases; Liver Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-mdm2; Receptors, Death Domain; Sesquiterpenes; STAT3 Transcription Factor; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53

2011
The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:6

    Topics: Andrographis; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Humans; Molecular Structure; Multiple Myeloma; Neoplastic Stem Cells; NF-kappa B; Plant Extracts; Sesquiterpenes; Tanacetum parthenium

2011
Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.
    Biochimica et biophysica acta, 2011, Volume: 1813, Issue:6

    Topics: Amino Acid Chloromethyl Ketones; Anthracenes; Antithrombins; Blotting, Western; Butadienes; Cell Line; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Enzyme Inhibitors; Flavonoids; Gene Expression; Glycoproteins; Hirudins; Humans; JNK Mitogen-Activated Protein Kinases; Lipoproteins, VLDL; Macrophages; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Signal Transduction; Sulfonamides; Thrombin; Time Factors

2011
Biosynthesis and localization of parthenolide in glandular trichomes of feverfew (Tanacetum parthenium L. Schulz Bip.).
    Phytochemistry, 2011, Volume: 72, Issue:14-15

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; DNA, Complementary; Escherichia coli; Flowers; Fruit; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Organ Specificity; Phylogeny; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plant Stems; Plants, Medicinal; Recombinant Proteins; RNA, Messenger; RNA, Plant; Sequence Alignment; Sesquiterpenes; Tanacetum parthenium

2011
Involvement of endoplasmic reticulum stress-mediated CHOP (GADD153) induction in the cytotoxicity of 2-aminophenoxazine-3-one in cancer cells.
    International journal of oncology, 2011, Volume: 39, Issue:4

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum; Gene Expression Profiling; HL-60 Cells; Humans; Mice; Mice, Knockout; NF-kappa B; Nitriles; Oxazines; Sesquiterpenes; Sulfones; Thapsigargin; Transcription Factor CHOP; Tunicamycin; Up-Regulation

2011
Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer androgen-independent cell lines.
    International journal of molecular medicine, 2011, Volume: 28, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor; Combined Modality Therapy; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; G2 Phase Cell Cycle Checkpoints; Hot Temperature; Humans; Hyperthermia, Induced; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Prostatic Neoplasms; Sesquiterpenes

2011
Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro.
    Molecules (Basel, Switzerland), 2011, Aug-09, Volume: 16, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcinoma; Cell Line, Tumor; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 2; Diffusion Chambers, Culture; Flow Cytometry; G1 Phase; Humans; Microscopy; Neoplasm Invasiveness; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Signal Transduction; Tanacetum parthenium; Urinary Bladder Neoplasms

2011
Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo.
    Journal of biochemical and molecular toxicology, 2012, Volume: 26, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cyclin D1; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Nuclear Receptor Co-Repressor 2; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays

2012
Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.
    Leukemia, 2012, Volume: 26, Issue:4

    Topics: Acetyltransferases; Animals; Cell Line; Cell Proliferation; Chickens; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Lactones; Leukemia, Myeloid, Acute; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myb; Sesquiterpenes

2012
Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines.
    Chemical biology & drug design, 2012, Volume: 79, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Humans; Isoxazoles; Lactones; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Sesquiterpenes; Urokinase-Type Plasminogen Activator

2012
Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats.
    Cytokine, 2011, Volume: 56, Issue:3

    Topics: Animals; Biomarkers; Body Temperature; CCAAT-Enhancer-Binding Protein-beta; Cells, Cultured; Cytokines; Encephalitis; Fever; Gene Expression Regulation; Hypothalamus; Injections, Intraperitoneal; Interleukin-6; Lipopolysaccharides; Male; Mitochondria; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Sesquiterpenes; Signal Transduction; Tumor Necrosis Factor-alpha

2011
Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments.
    Journal of medicinal chemistry, 2011, Nov-24, Volume: 54, Issue:22

    Topics: Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Deuterium; Drug Screening Assays, Antitumor; Fluorine; Glutathione; Humans; Lactones; Magnetic Resonance Spectroscopy; Molecular Probes; Molecular Structure; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship

2011
Targeting radioresistant osteosarcoma cells with parthenolide.
    Journal of cellular biochemistry, 2012, Volume: 113, Issue:4

    Topics: Blotting, Western; Bone Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Neoplastic Stem Cells; NF-kappa B; Osteosarcoma; Radiation Tolerance; Radiation, Ionizing; Reactive Oxygen Species; Sesquiterpenes

2012
9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity.
    Planta medica, 2012, Volume: 78, Issue:3

    Topics: Animals; Antiprotozoal Agents; Esters; Flowers; Inula; Leishmania donovani; Models, Animal; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plasmodium falciparum; Rats; Sesquiterpenes; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Turkey

2012
Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis.
    Cancer letters, 2012, May-01, Volume: 318, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-X Protein; Blotting, Western; Cell Proliferation; DNA-Binding Proteins; DNA, Neoplasm; Electrophoretic Mobility Shift Assay; Humans; Lymphoma, B-Cell; NF-kappa B; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-rel; Sesquiterpenes; Tumor Cells, Cultured

2012
Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates dextran sulfate sodium-induced colitis in mice.
    International immunopharmacology, 2012, Volume: 12, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; I-kappa B Proteins; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Peroxidase; Sesquiterpenes

2012
TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation.
    Kidney international, 2012, Volume: 81, Issue:11

    Topics: Adult; Animals; Antibodies, Neutralizing; Biopsy; Cell Line; Chemokine CXCL16; Chemokine CXCL6; Chemokines, CXC; Chemotaxis; Cytokine TWEAK; Disease Models, Animal; Female; Folic Acid; Gene Expression Profiling; Humans; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nephritis, Interstitial; NF-kappa B; Receptors, Scavenger; Receptors, Tumor Necrosis Factor; Recombinant Proteins; RNA, Messenger; Sesquiterpenes; T-Lymphocytes; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factors; TWEAK Receptor; Up-Regulation

2012
HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes.
    Antiviral therapy, 2012, Volume: 17, Issue:3

    Topics: Adipocytes; Adipogenesis; Cytokines; Gene Expression Regulation; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Inflammation; Resveratrol; Rosiglitazone; Sesquiterpenes; Stilbenes; tat Gene Products, Human Immunodeficiency Virus; Thiazolidinediones; Tumor Necrosis Factor-alpha

2012
Parthenolide inhibits the LPS-induced secretion of IL-6 and TNF-α and NF-κB nuclear translocation in BV-2 microglia.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:9

    Topics: Animals; Cell Line; Interleukin-6; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Protein Transport; Sesquiterpenes; Tanacetum parthenium; Tumor Necrosis Factor-alpha

2012
Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, May-12, Volume: 46, Issue:1-2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Carriers; Humans; Inhibitory Concentration 50; Lung Neoplasms; Magnetic Resonance Spectroscopy; Micelles; Paclitaxel; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Sesquiterpenes; Vitamin E

2012
Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Benzoquinones; Blotting, Western; Carcinoma, Ovarian Epithelial; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Survival; Cytochromes c; Female; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Mitochondria; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Reactive Oxygen Species; Sesquiterpenes; Tumor Suppressor Protein p53

2012
Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina.
    The International journal of developmental biology, 2012, Volume: 56, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Methamphetamine; N-Methylaspartate; Nicotine; Nicotinic Agonists; Planarians; Regeneration; Seizures; Sesquiterpenes

2012
Patch testing with constituents of Compositae mixes.
    Contact dermatitis, 2012, Volume: 66, Issue:5

    Topics: Allergens; Asteraceae; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Patch Tests; Plant Extracts; Sesquiterpenes

2012
Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model.
    Experimental & molecular medicine, 2012, Jul-31, Volume: 44, Issue:7

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Gene Expression; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Membrane Potential, Mitochondrial; NF-kappa B; Oxidative Stress; Rats; Reactive Oxygen Species; Sesquiterpenes; Thioacetamide; Tumor Necrosis Factor-alpha

2012
Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells.
    Journal of cellular physiology, 2013, Volume: 228, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis Inducing Factor; Caspase Inhibitors; Caspases; Cell Death; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Melanoma; NADPH Oxidases; NF-kappa B; Osteosarcoma; Reactive Oxygen Species; Sesquiterpenes

2013
Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma.
    Molecular medicine reports, 2012, Volume: 6, Issue:3

    Topics: Antiviral Agents; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Epstein-Barr Virus Infections; Ganciclovir; Herpesvirus 4, Human; Humans; Immediate-Early Proteins; NF-kappa B; Plants, Medicinal; Sesquiterpenes; Tanacetum parthenium; Trans-Activators

2012
Biomimetic semisynthesis of arglabin from parthenolide.
    The Journal of organic chemistry, 2012, Aug-17, Volume: 77, Issue:16

    Topics: Antineoplastic Agents; Biomimetics; Humans; Models, Molecular; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism

2012
Culture supernatants of breast cancer cell line MDA-MB-231 treated with parthenolide inhibit the proliferation, migration, and lumen formation capacity of human umbilical vein endothelial cells.
    Chinese medical journal, 2012, Volume: 125, Issue:12

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-8; Matrix Metalloproteinase 9; Sesquiterpenes; Vascular Endothelial Growth Factor A

2012
Parthenolide suppresses tumor growth in a xenograft model of colorectal cancer cells by inducing mitochondrial dysfunction and apoptosis.
    International journal of oncology, 2012, Volume: 41, Issue:4

    Topics: Apoptosis; Carcinogenesis; Colorectal Neoplasms; Cytochromes c; Genes, bcl-2; HT29 Cells; Humans; Mitochondria; Neovascularization, Pathologic; Sesquiterpenes; Signal Transduction; Xenograft Model Antitumor Assays

2012
Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21.
    Cancer prevention research (Philadelphia, Pa.), 2012, Volume: 5, Issue:11

    Topics: Animals; Animals, Newborn; Antineoplastic Agents, Phytogenic; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Neoplasms; Sesquiterpenes; Xenograft Model Antitumor Assays

2012
Involvement of Akt/NF-κB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo.
    BMC cancer, 2012, Oct-05, Volume: 12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis Regulatory Proteins; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Signal Transduction; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2012
Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines.
    Molecular biology reports, 2013, Volume: 40, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cell Shape; DNA Replication; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles; Lipid Peroxidation; MCF-7 Cells; Oxidative Stress; Sesquiterpenes; Transcription, Genetic

2013
Role of NF-κB activation in matrix metalloproteinase 9, vascular endothelial growth factor and interleukin 8 expression and secretion in human breast cancer cells.
    Cell biochemistry and function, 2013, Volume: 31, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; DNA; Electrophoretic Mobility Shift Assay; Female; Gene Expression; Humans; Interleukin-8; Matrix Metalloproteinase 9; NF-kappa B; Protein Binding; Sesquiterpenes; Vascular Endothelial Growth Factor A

2013
Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres.
    Cancer biology & therapy, 2013, Volume: 14, Issue:2

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Melanoma; Neoplastic Stem Cells; Sesquiterpenes; Spheroids, Cellular; Tumor Cells, Cultured

2013
Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia.
    Blood, 2013, Feb-21, Volume: 121, Issue:8

    Topics: Adolescent; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bone Marrow Cells; Cell Survival; Child; Child, Preschool; Disease Models, Animal; Female; Humans; Infant; Male; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Neoplasm Transplantation; NF-kappa B; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Secondary Prevention; Sesquiterpenes; Transplantation, Heterologous

2013
Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.
    Leukemia, 2013, Volume: 27, Issue:6

    Topics: Cell Line, Tumor; Dipeptidases; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Humans; Leukemia; Real-Time Polymerase Chain Reaction; Sesquiterpenes

2013
Biofilm inhibitors that target amyloid proteins.
    Chemistry & biology, 2013, Jan-24, Volume: 20, Issue:1

    Topics: Amyloidogenic Proteins; Anti-Bacterial Agents; Bacillus cereus; Bacillus subtilis; Bacterial Proteins; Benzoquinones; Biofilms; Escherichia coli; Humans; Sesquiterpenes

2013
Epidermal growth factor protects squamous cell carcinoma against cisplatin-induced cytotoxicity through increased interleukin-1β expression.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Biomarkers, Tumor; Blotting, Western; Carcinoma, Squamous Cell; Chromones; Cisplatin; Cytotoxins; DNA Primers; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1beta; Morpholines; NF-kappa B; Oncogene Protein v-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Sesquiterpenes; Signal Transduction

2013
Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer.
    Cancer letters, 2013, Jul-28, Volume: 335, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspase 9; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Cytochromes c; Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Mice; Mice, Nude; Mitochondria; Neoplasm Transplantation; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Xenograft Model Antitumor Assays

2013
Reversing resistance of multidrug-resistant hepatic carcinoma cells with parthenolide.
    Future oncology (London, England), 2013, Volume: 9, Issue:4

    Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorouracil; Humans; Liver Neoplasms; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Tumor Suppressor Protein p53; Wnt1 Protein

2013
NF-κB pathway contributes to cadmium-induced apoptosis of porcine granulosa cells.
    Biological trace element research, 2013, Volume: 153, Issue:1-3

    Topics: Animals; Apoptosis; Cadmium; Female; Granulosa Cells; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes; Swine

2013
Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates LPS-induced IFN-β and NO production in macrophages.
    Innate immunity, 2014, Volume: 20, Issue:1

    Topics: Animals; Cell Line; Gene Expression Regulation; Inflammation; Interferon Regulatory Factor-1; Interferon-beta; Lipopolysaccharides; Macrophages, Peritoneal; Mice; NF-kappa B; Nitric Oxide; Nuclear Proteins; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; STAT1 Transcription Factor; TNF Receptor-Associated Factor 6

2014
KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells.
    Cancer research, 2013, Jul-15, Volume: 73, Issue:14

    Topics: Animals; Antioxidants; bcl-X Protein; Carrier Proteins; Cell Line; Cell Line, Tumor; Epithelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Male; Mice; Mice, Nude; Mitochondrial Proteins; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Phosphoprotein Phosphatases; Prostatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Reactive Oxygen Species; Sesquiterpenes; Thioredoxins; Ubiquitin; Xenograft Model Antitumor Assays

2013
Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation.
    Journal of medicinal chemistry, 2013, Jun-13, Volume: 56, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; NF-kappa B; Paclitaxel; Polymerization; Sesquiterpenes; Structure-Activity Relationship; Taxoids; Tubulin; Tubulin Modulators

2013
Parthenolide from Parthenium integrifolium reduces tumor burden and alleviate cachexia symptoms in the murine CT-26 model of colorectal carcinoma.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Aug-15, Volume: 20, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Body Weight; Cachexia; Colorectal Neoplasms; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Muscle Proteins; Muscle, Skeletal; Neoplasm Transplantation; Organ Size; Phytotherapy; Plant Extracts; Sesquiterpenes; Tripartite Motif Proteins; Tumor Burden; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases

2013
Lipopolysaccharide prevents valproic acid-induced apoptosis via activation of nuclear factor-κB and inhibition of p53 activation.
    Cellular immunology, 2013, Volume: 282, Issue:2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Dose-Response Relationship, Drug; Immunoblotting; Lipopeptides; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitriles; Oligodeoxyribonucleotides; Poly I-C; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Sulfones; Toll-Like Receptor 9; Toll-Like Receptors; Tumor Suppressor Protein p53; Valproic Acid

2013
Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-κB activation and HSP70 up-regulation.
    Toxicology letters, 2013, Aug-14, Volume: 221, Issue:2

    Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; HSP70 Heat-Shock Proteins; Humans; In Situ Nick-End Labeling; Lung Neoplasms; Microscopy, Confocal; NF-kappa B; Sesquiterpenes; Signal Transduction; Up-Regulation

2013
Parthenolide enhances dacarbazine activity against melanoma cells.
    Anti-cancer drugs, 2013, Volume: 24, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Interleukin-8; Melanoma; NF-kappa B; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Skin Neoplasms; Vascular Endothelial Growth Factor A

2013
Parthenolide reduces cell proliferation and prostaglandin E2 [corrected] in human endometriotic stromal cells and inhibits development of endometriosis in the murine model.
    Fertility and sterility, 2013, Volume: 100, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endometriosis; Endometrium; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Gene Expression Regulation, Enzymologic; Humans; I-kappa B Proteins; Inflammation Mediators; Interleukin-8; Ki-67 Antigen; Mice; Mice, Inbred BALB C; Phosphorylation; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Signal Transduction; Stromal Cells; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2013
Parthenolide complements the cell death-inducing activity of doxorubicin in melanoma cells.
    Anticancer research, 2013, Volume: 33, Issue:8

    Topics: Cell Death; Cell Line, Tumor; Cell Survival; Doxorubicin; Humans; Melanoma; NF-kappa B; Sesquiterpenes; Tumor Suppressor Protein p53

2013
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
    Pain, 2013, Volume: 154, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cricetulus; Drug Delivery Systems; Flowers; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Plant Extracts; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tanacetum parthenium; Transient Receptor Potential Channels; Trigeminal Ganglion; Trigeminal Nerve; TRPA1 Cation Channel; Vasodilation

2013
Parthenolide is neuroprotective in rat experimental stroke model: downregulating NF-κB, phospho-p38MAPK, and caspase-1 and ameliorating BBB permeability.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Caspase 1; Claudin-5; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stroke

2013
In human retinoblastoma Y79 cells okadaic acid-parthenolide co-treatment induces synergistic apoptotic effects, with PTEN as a key player.
    Cancer biology & therapy, 2013, Oct-01, Volume: 14, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Shape; Cell Survival; Drug Screening Assays, Antitumor; Drug Synergism; Gene Expression; Glutathione; Humans; Okadaic Acid; Oxidative Stress; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; PTEN Phosphohydrolase; Reactive Oxygen Species; Retinoblastoma; Sesquiterpenes; Tumor Suppressor Protein p53

2013
Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition.
    Breast cancer research : BCR, 2013, Volume: 15, Issue:5

    Topics: Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; Female; Humans; Microtubules; NF-kappa B; Protein Processing, Post-Translational; Sesquiterpenes; Signal Transduction; Tubulin

2013
Protection-group-free semisyntheses of parthenolide and its cyclopropyl analogue.
    The Journal of organic chemistry, 2013, Oct-18, Volume: 78, Issue:20

    Topics: Apoptosis; Cell Line, Tumor; Cyclopropanes; Humans; Sesquiterpenes

2013
Parthenolide induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits FAK-mediated cell invasion.
    Molecular and cellular biochemistry, 2014, Volume: 385, Issue:1-2

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; DNA Damage; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Invasiveness; Oxidants; Reactive Oxygen Species; Receptors, Death Domain; Sesquiterpenes; Signal Transduction

2014
Age sensitivity of NFκB abundance and programmed cell death in erythrocytes induced by NFκB inhibitors.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 32, Issue:4

    Topics: Aging; Apoptosis; Cells, Cultured; Erythrocytes; Humans; NF-kappa B; Nitriles; Sesquiterpenes; Sulfones; Time Factors

2013
St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes.
    Fitoterapia, 2014, Volume: 92

    Topics: Animals; Anthracenes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Flowers; Hyperalgesia; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Seeds; Sesquiterpenes; Tanacetum parthenium; Terpenes

2014
Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.
    International journal of oncology, 2013, Volume: 43, Issue:6

    Topics: Acetophenones; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; NADPH Oxidases; NF-kappa B; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Sesquiterpenes; Superoxides; Tyrphostins

2013
[Effects of parthenolide on high glucose-induced cell proliferation, NF-κB activation and MCP-1 expression in rat mesangial cells].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2013, Volume: 33, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Glucose; I-kappa B Proteins; Mesangial Cells; NF-kappa B; NF-KappaB Inhibitor alpha; Plants, Medicinal; Rats; Sesquiterpenes

2013
Synthetic α-(aminomethyl)-γ-butyrolactones and their anti-pancreatic cancer activities.
    Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24

    Topics: 4-Butyrolactone; Amination; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Pancreatic Neoplasms; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship

2013
Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer.
    Cell death & disease, 2013, Oct-31, Volume: 4

    Topics: Animals; Autophagy; Breast Neoplasms; Calcium; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Fas-Associated Death Domain Protein; Female; Humans; Membrane Potential, Mitochondrial; Mice; NF-kappa B; Nuclear Pore Complex Proteins; Reactive Oxygen Species; RNA-Binding Proteins; Sesquiterpenes; Xenograft Model Antitumor Assays

2013
Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
    ACS chemical biology, 2014, Jan-17, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Biocatalysis; Cytochrome P-450 Enzyme System; Drug Discovery; Humans; Leukemia, Myeloid, Acute; Models, Molecular; Oxidation-Reduction; Sesquiterpenes; Tumor Cells, Cultured

2014
Parthenolide inhibits polyethylene particle-induced mouse calvarial osteolysis in vivo.
    The Journal of surgical research, 2014, Volume: 187, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Lactones; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Osteolysis; Polyethylene; Prosthesis Failure; Sesquiterpenes; Skull; X-Ray Microtomography

2014
Parthenolide inhibits osteoclast differentiation and bone resorbing activity by down-regulation of NFATc1 induction and c-Fos stability, during RANKL-mediated osteoclastogenesis.
    BMB reports, 2014, Volume: 47, Issue:8

    Topics: Animals; Bone Marrow Cells; Bone Resorption; Cathepsin K; Cell Differentiation; Cells, Cultured; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Macrophages; Male; Mice; Mice, Inbred ICR; NFATC Transcription Factors; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Stability; Proto-Oncogene Proteins c-fos; RANK Ligand; Sesquiterpenes

2014
Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells.
    Journal of experimental & clinical cancer research : CR, 2014, Jan-06, Volume: 33

    Topics: Activating Transcription Factor 4; Antineoplastic Agents; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression; Humans; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Neoplastic Stem Cells; Proto-Oncogene Proteins c-bcl-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sesquiterpenes; Transcription Factor CHOP; Up-Regulation

2014
Analysis of gene profiles involved in the enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by sesquiterpene lactones identifies asparagine synthetase as a novel target for differentiation-inducing therapy.
    International journal of oncology, 2014, Volume: 44, Issue:3

    Topics: Asparagine; Aspartate-Ammonia Ligase; Cell Differentiation; Culture Media; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Oligonucleotide Array Sequence Analysis; Receptors, Retinoic Acid; Sesquiterpenes; Sesquiterpenes, Guaiane; Tretinoin

2014
ROCK/NF-κB axis-dependent augmentation of angiotensinogen by angiotensin II in primary-cultured preglomerular vascular smooth muscle cells.
    American journal of physiology. Renal physiology, 2014, Mar-15, Volume: 306, Issue:6

    Topics: Angiotensin II; Angiotensinogen; Animals; Cells, Cultured; Male; Muscle, Smooth, Vascular; NF-kappa B; Rats; rho-Associated Kinases; Sesquiterpenes

2014
[Effect of parthenolide on serum expressions of interleukin-1beta and tumor necrosis factor-alpha in rabbits with knee osteoarthritis].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2013, Volume: 33, Issue:10

    Topics: Animals; Female; Interleukin-1beta; Male; Osteoarthritis, Knee; Phytotherapy; Rabbits; Sesquiterpenes; Tumor Necrosis Factor-alpha

2013
Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer.
    International journal of molecular medicine, 2014, Volume: 33, Issue:5

    Topics: Cell Movement; Cell Survival; Colorectal Neoplasms; HCT116 Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Pathologic; Receptors, Vascular Endothelial Growth Factor; Sesquiterpenes; Vascular Endothelial Growth Factor A

2014
New cassane-type diterpenoids of Caesalpinia echinata (Leguminosae) exhibiting NF-κB inhibitory activities.
    Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:3

    Topics: Caesalpinia; Diterpenes; Gene Expression; Genes, Reporter; HeLa Cells; Humans; Molecular Structure; NF-kappa B; Plant Extracts; Plant Stems; Sesquiterpenes; Structure-Activity Relationship

2014
Parthenium dermatitis: is parthenolide an effective choice for patch testing?
    Contact dermatitis, 2014, Volume: 70, Issue:6

    Topics: Adolescent; Adult; Asteraceae; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Parthenogenesis; Patch Tests; Plant Extracts; Prospective Studies; Sesquiterpenes; Young Adult

2014
Inhibition of AMPK/autophagy potentiates parthenolide-induced apoptosis in human breast cancer cells.
    Journal of cellular biochemistry, 2014, Volume: 115, Issue:8

    Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Breast Neoplasms; Cell Cycle Checkpoints; Female; Humans; MCF-7 Cells; Reactive Oxygen Species; Sesquiterpenes

2014
Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.
    Bioorganic & medicinal chemistry letters, 2014, Apr-15, Volume: 24, Issue:8

    Topics: Animals; Dose-Response Relationship, Drug; G2 Phase; Heterocyclic Compounds; Mitosis; Molecular Structure; Oocytes; Sesquiterpenes; Xenopus

2014
Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway.
    Metabolic engineering, 2014, Volume: 23

    Topics: Metabolomics; Nicotiana; Plant Proteins; Plants, Genetically Modified; Sesquiterpenes; Tanacetum parthenium

2014
The oxygen radicals involved in the toxicity induced by parthenolide in MDA-MB-231 cells.
    Oncology reports, 2014, Volume: 32, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Humans; Hydrogen Peroxide; Mitochondria; NADPH Oxidases; Sesquiterpenes; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides

2014
RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation.
    Acta pharmacologica Sinica, 2014, Volume: 35, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Sesquiterpenes; Up-Regulation

2014
Cell death in amastigote forms of Leishmania amazonensis induced by parthenolide.
    BMC microbiology, 2014, Jun-10, Volume: 14

    Topics: Animals; Antiprotozoal Agents; Cell Death; Cell Membrane; Female; Inhibitory Concentration 50; Leishmania mexicana; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Organelles; Sesquiterpenes

2014
Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:8

    Topics: Animals; Antineoplastic Agents; Caspases; Cell Survival; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Lethal Dose 50; Leukemia, Myeloid, Acute; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Phenylbutyrates; Sesquiterpenes; Transcriptome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2014
Synthesis and biological evaluation of 9α- and 9β-hydroxyamino-parthenolides as novel anticancer agents.
    Bioorganic & medicinal chemistry letters, 2014, Aug-15, Volume: 24, Issue:16

    Topics: Amines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mice; Molecular Conformation; Sesquiterpenes; Structure-Activity Relationship

2014
Parthenolide-induced apoptosis, autophagy and suppression of proliferation in HepG2 cells.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Fluorescent Antibody Technique; Hep G2 Cells; Humans; Liver Neoplasms; Sesquiterpenes

2014
Total syntheses of parthenolide and its analogues with macrocyclic stereocontrol.
    Journal of medicinal chemistry, 2014, Aug-28, Volume: 57, Issue:16

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Neoplasms; Sesquiterpenes; Structure-Activity Relationship

2014
Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression.
    European journal of medicinal chemistry, 2014, Oct-06, Volume: 85

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Humans; Oocytes; Sesquiterpenes; Structure-Activity Relationship; Xenopus

2014
Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Animals; Butadienes; Disease Models, Animal; Drug Synergism; Hyperalgesia; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Morphine; Neuralgia; NF-kappa B; Nitriles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sciatic Nerve; Sesquiterpenes; Signal Transduction

2014
PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL.
    Journal of leukocyte biology, 2014, Volume: 96, Issue:6

    Topics: Anthracenes; Apoptosis; bcl-X Protein; Caffeic Acids; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Regulation, Developmental; Hematopoiesis; Humans; Macrophage Colony-Stimulating Factor; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; Tetradecanoylphorbol Acetate

2014
[Shenkang pill down-regulates AOPP-induced expression of inflammatory factor MCP-1 via a p38MAPK/NF-κB-dependent mechanism].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014, Volume: 34, Issue:9

    Topics: Advanced Oxidation Protein Products; Animals; Cell Line; Cell Proliferation; Chemokine CCL2; Down-Regulation; Drugs, Chinese Herbal; I-kappa B Proteins; Imidazoles; Mice; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Serum; Sesquiterpenes; Transcription Factor RelA

2014
Effect of parthenolide on growth and apoptosis regulatory genes of human cancer cell lines.
    Pharmaceutical biology, 2015, Volume: 53, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Cell Culture Techniques; Cell Proliferation; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Gene Expression; Humans; MCF-7 Cells; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Tanacetum parthenium

2015
The synergistic effect of SAHA and parthenolide in MDA-MB231 breast cancer cells.
    Journal of cellular physiology, 2015, Volume: 230, Issue:6

    Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Drug Synergism; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; NF-kappa B; Sesquiterpenes; Vorinostat

2015
Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model.
    Scandinavian journal of rheumatology, 2015, Volume: 44, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Interleukin-1beta; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; NF-kappa B; Nitric Oxide Synthase Type II; Rats; RNA, Messenger; Sesquiterpenes; Synovial Membrane; Tumor Necrosis Factor-alpha

2015
Parthenolide induces autophagy via the depletion of 4E-BP1.
    Biochemical and biophysical research communications, 2015, Jan-02, Volume: 456, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Autophagy; Carrier Proteins; Cell Cycle Proteins; Eukaryotic Initiation Factors; Fibroblasts; HEK293 Cells; HeLa Cells; HL-60 Cells; Humans; Mice; Phagosomes; Phosphoproteins; Phosphorylation; Plasmids; Reactive Oxygen Species; RNA, Small Interfering; Sesquiterpenes; Signal Transduction

2015
Parthenolide enhances sensitivity of colorectal cancer cells to TRAIL by inducing death receptor 5 and promotes TRAIL-induced apoptosis.
    International journal of oncology, 2015, Volume: 46, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Cells, Cultured; Colorectal Neoplasms; Drug Synergism; HCT116 Cells; HT29 Cells; Humans; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sesquiterpenes; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation

2015
Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway.
    Theranostics, 2015, Volume: 5, Issue:3

    Topics: Antineoplastic Agents; Blotting, Western; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Gene Expression Profiling; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplastic Stem Cells; NF-kappa B; Real-Time Polymerase Chain Reaction; Sesquiterpenes; Signal Transduction

2015
Suppression of tubulin detyrosination by parthenolide recruits the plant-specific kinesin KCH to cortical microtubules.
    Journal of experimental botany, 2015, Volume: 66, Issue:7

    Topics: Carboxypeptidases; Cell Line; Cells, Cultured; Genes, Reporter; Kinesins; Microtubules; Nicotiana; Peptide Synthases; Plant Proteins; Plants, Genetically Modified; Sesquiterpenes; Tubulin; Tyrosine

2015
Induction of apoptosis by parthenolide in human oral cancer cell lines and tumor xenografts.
    Oral oncology, 2015, Volume: 51, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Caspase 8; Cell Line, Tumor; Female; Humans; Membrane Proteins; Mice; Mice, Nude; Mitochondria; Mouth Neoplasms; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Messenger; RNA, Small Interfering; Sesquiterpenes

2015
Parthenolide inhibits LPS-induced inflammatory cytokines through the toll-like receptor 4 signal pathway in THP-1 cells.
    Acta biochimica et biophysica Sinica, 2015, Volume: 47, Issue:5

    Topics: Cell Line; Cytokines; Humans; Inflammation Mediators; Lipopolysaccharides; Sesquiterpenes; Signal Transduction; Toll-Like Receptor 4

2015
The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation.
    Aging cell, 2015, Volume: 14, Issue:4

    Topics: Acetylcysteine; Antioxidants; Autophagy; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cellular Senescence; Gene Expression Regulation; Humans; Interleukin-6; Interleukin-8; Mesenchymal Stem Cells; Mitochondria; nef Gene Products, Human Immunodeficiency Virus; NF-kappa B; Osteoblasts; Osteocalcin; Oxidative Stress; Primary Cell Culture; Recombinant Proteins; Sesquiterpenes; Signal Transduction; Sirolimus; tat Gene Products, Human Immunodeficiency Virus

2015
Induction of survivin inhibition, G₂/M cell cycle arrest and autophagic on cell death in human malignant glioblastoma cells.
    The Chinese journal of physiology, 2015, Apr-30, Volume: 58, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; M Phase Cell Cycle Checkpoints; Sesquiterpenes; Survivin; Treatment Outcome

2015
Covalent modification of human serum albumin by the natural sesquiterpene lactone parthenolide.
    Molecules (Basel, Switzerland), 2015, Apr-09, Volume: 20, Issue:4

    Topics: Cysteine; Humans; Plant Extracts; Serum Albumin; Sesquiterpenes; Tanacetum parthenium

2015
Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis.
    Journal of biomedical materials research. Part A, 2015, Volume: 103, Issue:11

    Topics: Animals; Bone Resorption; Collagen Type I; Humans; Mice; Models, Animal; Organ Size; Osteoarthritis; Osteoclasts; Osteolysis; Peptides; Polyethylene; Prostheses and Implants; Receptors, Cell Surface; Sesquiterpenes; Skull; Solubility; X-Ray Microtomography

2015
Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-κB pathways.
    Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:9

    Topics: Humans; Inflammation Mediators; Keratinocytes; Lipopolysaccharides; NF-kappa B; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Toll-Like Receptor 4; TOR Serine-Threonine Kinases

2015
Parthenolide prodrug LC-1 slows growth of intracranial glioma.
    Bioorganic & medicinal chemistry letters, 2015, Jun-15, Volume: 25, Issue:12

    Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Glioma; Half-Life; Kaplan-Meier Estimate; Mice; Prodrugs; Sesquiterpenes

2015
Inhibitory effects of parthenolide on the activity of NF-κB in multiple myeloma via targeting TRAF6.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2015, Volume: 35, Issue:3

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Multiple Myeloma; NF-kappa B; Sesquiterpenes; TNF Receptor-Associated Factor 6; Transcription Factor RelA; Ubiquitination

2015
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
    Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

    Topics: Alkenes; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Conformation; Neoplastic Stem Cells; Reactive Oxygen Species; Sesquiterpenes

2015
Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy.
    Neural plasticity, 2015, Volume: 2015

    Topics: Analgesics; Animals; Cell Polarity; Cells, Cultured; Chronic Disease; Hyperalgesia; Macrophages; Male; Microglia; Neuralgia; Rats; Rats, Wistar; Sciatic Neuropathy; Sesquiterpenes; Signal Transduction

2015
Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium.
    Plant cell reports, 2015, Volume: 34, Issue:11

    Topics: Acetates; Cyclopentanes; Gene Expression Regulation, Plant; Oxylipins; Plant Growth Regulators; Salicylic Acid; Sesquiterpenes; Tanacetum parthenium

2015
Syntheses and Biological Evaluation of Costunolide, Parthenolide, and Their Fluorinated Analogues.
    Journal of medicinal chemistry, 2015, Sep-10, Volume: 58, Issue:17

    Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Fluorine; Half-Life; Halogenation; Humans; Microsomes, Liver; Rats; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship

2015
The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment.
    Oncotarget, 2015, Oct-20, Volume: 6, Issue:32

    Topics: Animals; Apoptosis; Base Sequence; Cell Differentiation; Erythropoiesis; HEK293 Cells; Humans; Leukemia; Mice; Mice, Inbred C57BL; MicroRNAs; Molecular Sequence Data; Promoter Regions, Genetic; Sesquiterpenes; Transcription Factor RelA; Up-Regulation

2015
Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.
    Journal of medicinal chemistry, 2015, Nov-25, Volume: 58, Issue:22

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Dimerization; Drug Screening Assays, Antitumor; Gliosarcoma; Hematologic Neoplasms; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Neoplasms; Primary Cell Culture; Rats; Sesquiterpenes; Structure-Activity Relationship; Tumor Stem Cell Assay

2015
Repressed Ca(2+) clearance in parthenolide-treated murine brain bEND.3 endothelial cells.
    European journal of pharmacology, 2015, Dec-15, Volume: 769

    Topics: Animals; Calcium; Calcium Signaling; Cell Line; Cell Membrane; Cytoprotection; Endoplasmic Reticulum Stress; Endothelial Cells; Homeostasis; Mice; Microvessels; Sesquiterpenes

2015
In vivo targeting of leukemia stem cells by directing parthenolide-loaded nanoparticles to the bone marrow niche.
    Leukemia, 2016, Volume: 30, Issue:7

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Drug Delivery Systems; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; Neoplastic Stem Cells; Sesquiterpenes; Stem Cell Niche; Xenograft Model Antitumor Assays

2016
Determination of parthenolide in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 2016, Feb-05, Volume: 119

    Topics: Administration, Oral; Animals; Calibration; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; In Vitro Techniques; Injections, Intravenous; Limit of Detection; Male; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Tandem Mass Spectrometry

2016
Ruscogenin exerts beneficial effects on monocrotaline-induced pulmonary hypertension by inhibiting NF-κB expression.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:10

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Platelet-Derived Growth Factor; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spirostans

2015
The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:4

    Topics: Animals; Anopheles; Antimalarials; Artemisinins; Drug Resistance; Erythrocytes; Female; Gene Expression; Genes, Reporter; Green Fluorescent Proteins; Humans; Inhibitory Concentration 50; Life Cycle Stages; Malaria; Male; Mice; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes

2016
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations.
    Oncotarget, 2016, Feb-23, Volume: 7, Issue:8

    Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Histone Deacetylase 1; Humans; MAP Kinase Signaling System; Melanoma; Microphthalmia-Associated Transcription Factor; Myeloid Cell Leukemia Sequence 1 Protein; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Sesquiterpenes; Transcription Factor RelA; Tumor Cells, Cultured

2016
Anticancer activity and radiosensitization effect of methyleneisoxazolidin-5-ones in hepatocellular carcinoma HepG2 cells.
    Chemico-biological interactions, 2016, Mar-25, Volume: 248

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Cell Survival; DNA Damage; Hep G2 Cells; Humans; Isoxazoles; Membrane Potential, Mitochondrial; Radiation-Sensitizing Agents; Reactive Oxygen Species; Sesquiterpenes

2016
Relative In Vitro Potentials of Parthenolide to Induce Apoptosis and Cell Cycle Arrest in Skin Cancer Cells.
    Current drug discovery technologies, 2016, Volume: 13, Issue:1

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Sesquiterpenes; Skin Neoplasms

2016
Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells.
    The Journal of biological chemistry, 2016, May-06, Volume: 291, Issue:19

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; HeLa Cells; Humans; NADPH Oxidases; Neoplasm Proteins; Neoplasms; Sesquiterpenes; Superoxides; Tanacetum parthenium; Thioredoxin Reductase 1; Thioredoxin Reductase 2

2016
Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Apr-06, Volume: 36, Issue:14

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Axons; Dose-Response Relationship, Drug; Gene Knock-In Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL; Microtubules; Nerve Regeneration; Nocodazole; Paclitaxel; Peripheral Nerves; Phosphorylation; Sciatic Nerve; Sesquiterpenes; Tyrosine

2016
Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells.
    Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4

    Topics: Antineoplastic Agents; Asteraceae; Blotting, Western; Drug Screening Assays, Antitumor; Ecuador; HeLa Cells; HL-60 Cells; Humans; Lactones; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Medicine, Traditional; Molecular Structure; Sesquiterpenes

2016
Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis.
    Cell death & disease, 2016, Apr-14, Volume: 7

    Topics: Acetophenones; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Fluorescent Dyes; Humans; Membrane Potential, Mitochondrial; Mitochondria; NADPH Oxidases; Neoplastic Stem Cells; NF-E2-Related Factor 2; Oligopeptides; Onium Compounds; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Sesquiterpenes; Transcription Factors

2016
Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer.
    Biotechnology letters, 2016, Volume: 38, Issue:8

    Topics: Apoptosis; Autophagy; Female; HeLa Cells; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Uterine Cervical Neoplasms

2016
Parthenolide ameliorates Concanavalin A-induced acute hepatitis in mice and modulates the macrophages to an anti-inflammatory state.
    International immunopharmacology, 2016, Volume: 38

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Concanavalin A; Cytokines; Disease Models, Animal; Hepatitis; Humans; Immunity, Cellular; Inflammation Mediators; Liver; Macrophages; Male; Mice; p38 Mitogen-Activated Protein Kinases; RAW 264.7 Cells; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Tumor Suppressor Protein p53

2016
Pharmacological targeting of glucose-6-phosphate dehydrogenase in human erythrocytes by Bay 11-7082, parthenolide and dimethyl fumarate.
    Scientific reports, 2016, 06-29, Volume: 6

    Topics: Dimethyl Fumarate; Eryptosis; Erythrocytes; Glucosephosphate Dehydrogenase; Humans; Nitriles; Sesquiterpenes; Sulfones

2016
Magnesium and manganese interactively modulate parthenolide accumulation and the antioxidant defense system in the leaves of Tanacetum parthenium.
    Journal of plant physiology, 2016, Sep-01, Volume: 202

    Topics: Antioxidants; Biosynthetic Pathways; Gene Expression Regulation, Plant; Magnesium; Malondialdehyde; Manganese; Metabolic Networks and Pathways; Pigments, Biological; Plant Leaves; Plant Roots; Plant Shoots; Proline; Sesquiterpenes; Tanacetum parthenium

2016
Parthenolide, an NF-κB Inhibitor Ameliorates Diabetes-Induced Behavioural Deficit, Neurotransmitter Imbalance and Neuroinflammation in Type 2 Diabetes Rat Model.
    Neuromolecular medicine, 2017, Volume: 19, Issue:1

    Topics: Acetylcholinesterase; Animals; Avoidance Learning; Behavior, Animal; Blood Glucose; Brain Chemistry; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Exploratory Behavior; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Interleukin-6; Maze Learning; Neurotransmitter Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Streptozocin; Tumor Necrosis Factor-alpha

2017
Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
    The Journal of biological chemistry, 2016, Oct-14, Volume: 291, Issue:42

    Topics: Antineoplastic Combined Chemotherapy Protocols; Deoxyglucose; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Male; NADP; Neoplasm Proteins; Neoplastic Stem Cells; NF-E2-Related Factor 2; Sesquiterpenes; Sirolimus; Up-Regulation

2016
Synthesis of (±)-4,5-dia-Parthenolide, an Unnatural Parthenolide Stereoisomer.
    The Journal of organic chemistry, 2016, 11-18, Volume: 81, Issue:22

    Topics: Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Chromatography, High Pressure Liquid; Cyclization; Esterification; Hydroxylation; Proton Magnetic Resonance Spectroscopy; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

2016
Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury.
    Archives of pharmacal research, 2016, Volume: 39, Issue:12

    Topics: A549 Cells; Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Humans; Lactones; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Protective Agents; Sesquiterpenes

2016
Parthenolide Induces Reactive Oxygen Species-Mediated Autophagic Cell Death in Human Osteosarcoma Cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 40, Issue:1-2

    Topics: Autophagy; Caspase 3; Cell Line, Tumor; Humans; Mitophagy; Osteosarcoma; Reactive Oxygen Species; Sesquiterpenes

2016
Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives.
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Sesquiterpenes; Structure-Activity Relationship

2017
Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation.
    Molecular cancer research : MCR, 2017, Volume: 15, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinogenesis; Cell Proliferation; Colitis; Colorectal Neoplasms; Drug Synergism; Female; Humans; Mesalamine; Mice; Mice, Inbred BALB C; NF-kappa B; Phenylhydrazines; Sesquiterpenes; Signal Transduction

2017
Functionalized Triblock Copolymer Vectors for the Treatment of Acute Lymphoblastic Leukemia.
    Molecular pharmaceutics, 2017, 03-06, Volume: 14, Issue:3

    Topics: Biocompatible Materials; Cells, Cultured; Drug Carriers; Drug Stability; Emulsions; Humans; Mesenchymal Stem Cells; Micelles; Polymers; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sesquiterpenes; Solubility; Solvents

2017
An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation.
    Transplantation, 2017, Volume: 101, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Arteries; Blood Coagulation; Blood Platelets; C-Reactive Protein; Heart Transplantation; Heterografts; Histones; Humans; Immunosuppressive Agents; Inflammation; Inflammation Mediators; Kidney Transplantation; Liver Transplantation; NF-kappa B; Papio; Platelet Aggregation; Platelet Count; Serum Amyloid A Protein; Sesquiterpenes; Sus scrofa; Time Factors; Triiodothyronine

2017
Synthesis of dual-action parthenolide prodrugs as potent anticancer agents.
    Bioorganic chemistry, 2017, Volume: 71

    Topics: Antineoplastic Agents; Apoptosis; Catalysis; Cell Line, Tumor; Chemistry Techniques, Synthetic; Cytarabine; Humans; Lactones; Melphalan; Neoplasms; Prodrugs; Sesquiterpenes

2017
Parthenolide inhibits the initiation of experimental autoimmune neuritis.
    Journal of neuroimmunology, 2017, 04-15, Volume: 305

    Topics: Analysis of Variance; Animals; Annexin A5; Anti-Inflammatory Agents; Apoptosis; CD4-Positive T-Lymphocytes; Cell Proliferation; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Forkhead Box Protein O3; Freund's Adjuvant; Lymph Nodes; Mycobacterium tuberculosis; Neuritis, Autoimmune, Experimental; Rats; Rats, Inbred Lew; Sciatic Nerve; Sesquiterpenes

2017
Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: Animals; Apoptosis; Brain Ischemia; Cell Line, Tumor; Glucose; Glycogen Synthase Kinase 3 beta; Neurons; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Oxygen; PC12 Cells; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury; Sesquiterpenes; Signal Transduction

2017
Parthenolide reduces gene transcription of prosurvival mediators in U937 cells.
    Experimental oncology, 2017, Volume: 39, Issue:1

    Topics: beta Catenin; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Osteopontin; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sesquiterpenes; TOR Serine-Threonine Kinases; Transcription Factor RelB; Transcription, Genetic; Tumor Stem Cell Assay; U937 Cells

2017
Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo.
    Radiation research, 2017, Volume: 187, Issue:5

    Topics: Animals; Antineoplastic Agents; Chemoradiotherapy; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Male; Mice; Mice, Transgenic; Organ Sparing Treatments; Organs at Risk; Prostatic Neoplasms; Radiation Injuries; Radiation Tolerance; Radiation-Sensitizing Agents; Sesquiterpenes; Treatment Outcome

2017
Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway.
    Oncotarget, 2017, Apr-04, Volume: 8, Issue:14

    Topics: A549 Cells; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Humans; Immunohistochemistry; Inhibitory Concentration 50; Lung Neoplasms; Male; MAP Kinase Signaling System; Middle Aged; Phosphorylation; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sesquiterpenes; STAT3 Transcription Factor

2017
Synergistic anti-cancer effects of epigenetic drugs on medulloblastoma cells.
    Cellular oncology (Dordrecht), 2017, Volume: 40, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Line, Tumor; Cerebellar Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Medulloblastoma; Sesquiterpenes

2017
Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia.
    Oncotarget, 2017, Jun-13, Volume: 8, Issue:24

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Mice; Mice, Inbred NOD; Mice, SCID; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays

2017
Hepatoprotective effect of parthenolide in rat model of nonalcoholic fatty liver disease.
    Immunopharmacology and immunotoxicology, 2017, Volume: 39, Issue:4

    Topics: Alanine Transaminase; Animals; Antioxidants; Diet, High-Fat; Disease Models, Animal; Liver; Male; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Sesquiterpenes; Superoxide Dismutase; Triglycerides; Tumor Necrosis Factor-alpha

2017
Parthenolide attenuates 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis.
    Molecular and cellular biochemistry, 2018, Volume: 440, Issue:1-2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis Regulatory Proteins; Benz(a)Anthracenes; Cheek; Cricetinae; Mouth Mucosa; Mouth Neoplasms; Neoplasm Proteins; Sesquiterpenes

2018
Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
    Bioorganic & medicinal chemistry, 2018, 04-01, Volume: 26, Issue:7

    Topics: Antineoplastic Agents; Cell Proliferation; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured

2018
Parthenolide Promotes Differentiation of Osteoblasts Through the Wnt/β-Catenin Signaling Pathway in Inflammatory Environments.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2017, Volume: 37, Issue:9

    Topics: Cell Differentiation; Cell Proliferation; Cells, Cultured; Humans; Inflammation; Osteoblasts; Sesquiterpenes; Wnt Signaling Pathway

2017
Smad4 re-expression increases the sensitivity to parthenolide in colorectal cancer.
    Oncology reports, 2017, Volume: 38, Issue:4

    Topics: Animals; Caco-2 Cells; Colorectal Neoplasms; Combined Modality Therapy; Drug Resistance, Neoplasm; Genetic Therapy; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Male; Mice; Mice, Inbred C3H; Random Allocation; Sesquiterpenes; Smad4 Protein; Transfection; Xenograft Model Antitumor Assays

2017
Pharmacological evidence for the bone-autonomous contribution of the NFκB/β-catenin axis to breast cancer related osteolysis.
    Cancer letters, 2017, 12-01, Volume: 410

    Topics: Animals; Apoptosis; beta Catenin; Bone Neoplasms; Breast Neoplasms; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Osteoblasts; Osteoclasts; Osteogenesis; Osteolysis; Sesquiterpenes; Signal Transduction; Time Factors

2017
Parthenolide suppresses hypoxia-inducible factor-1α signaling and hypoxia induced epithelial-mesenchymal transition in colorectal cancer.
    International journal of oncology, 2017, Volume: 51, Issue:6

    Topics: Animals; Cell Hypoxia; Colonic Neoplasms; Down-Regulation; Epithelial-Mesenchymal Transition; Female; HCT116 Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; NF-kappa B; Sesquiterpenes; Signal Transduction; Xenograft Model Antitumor Assays

2017
Schizonticidal antimalarial sesquiterpene lactones from Magnolia champaca (L.) Baill. ex Pierre: microwave-assisted extraction, HPTLC fingerprinting and computational studies.
    Natural product research, 2019, Volume: 33, Issue:4

    Topics: Antimalarials; Antiprotozoal Agents; Chromatography, High Pressure Liquid; Lactones; Magnolia; Microwaves; Molecular Docking Simulation; Plant Extracts; Sesquiterpenes; Spectrum Analysis

2019
LPS-induced Src family kinases activity mediates IL-10 production through activation of STAT3 in peripheral blood mononuclear cells of patients with Behçet's Disease.
    Cellular and molecular biology (Noisy-le-Grand, France), 2017, Oct-31, Volume: 63, Issue:10

    Topics: Adult; Behcet Syndrome; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-10; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Phosphorylation; Pyrimidines; Sesquiterpenes; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Toll-Like Receptor 4

2017
Protective effects of glutathione on oxidative injury induced by hydrogen peroxide in intestinal epithelial cells.
    The Journal of surgical research, 2018, Volume: 222

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Cell Line; Drug Evaluation, Preclinical; Glutathione; Hydrogen Peroxide; Interleukin-1beta; Intestinal Diseases; Intestinal Mucosa; MAP Kinase Signaling System; NF-kappa B; Oxidative Stress; Rats; Sesquiterpenes

2018
Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
    Journal of natural products, 2018, 03-23, Volume: 81, Issue:3

    Topics: Apoptosis; Asteraceae; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia, Myeloid, Acute; NF-kappa B; Sesquiterpenes

2018
The plant sesquiterpene lactone parthenolide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1.
    The Journal of biological chemistry, 2018, 04-06, Volume: 293, Issue:14

    Topics: beta Catenin; Cell Line, Tumor; HEK293 Cells; Humans; Lactones; Lymphoid Enhancer-Binding Factor 1; Promoter Regions, Genetic; Ribosomal Protein L10; Ribosomal Proteins; Sesquiterpenes; Signal Transduction; Transcription Factor 4; Transcription Factors; Transcriptional Activation; Wnt Signaling Pathway

2018
Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor α - 1 expression.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Mar-01, Volume: 41

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Death; Female; Humans; MCF-7 Cells; Peptide Elongation Factor 1; Sesquiterpenes; Tanacetum parthenium; Vimentin

2018
Exploring the impact of parthenolide as anti-quorum sensing and anti-biofilm agent against Pseudomonas aeruginosa.
    Life sciences, 2018, Apr-15, Volume: 199

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biofilms; Microbial Sensitivity Tests; Molecular Docking Simulation; Protein Structure, Secondary; Pseudomonas aeruginosa; Quorum Sensing; Sesquiterpenes

2018
Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis.
    Molecular medicine reports, 2018, Volume: 17, Issue:6

    Topics: Apoptosis; Cell Survival; Child; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Malondialdehyde; Osteoblasts; Oxidative Stress; Reactive Oxygen Species; Sesquiterpenes; Superoxide Dismutase

2018
Inhibition of NF-κB results in anti-glioma activity and reduces temozolomide-induced chemoresistance by down-regulating MGMT gene expression.
    Cancer letters, 2018, 08-01, Volume: 428

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Cell Line, Tumor; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Mice; Mice, SCID; Rats; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; Temozolomide; Transcription Factor RelA; Treatment Outcome; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2018
Investigating chemoresistance to improve sensitivity of childhood T-cell acute lymphoblastic leukemia to parthenolide.
    Haematologica, 2018, Volume: 103, Issue:9

    Topics: Adolescent; Biomarkers; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Coculture Techniques; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Male; Mesenchymal Stem Cells; Oxidative Stress; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Reactive Oxygen Species; Sesquiterpenes

2018
Crucial role of oxidative stress in bactericidal effect of parthenolide against Xanthomonas oryzae pv. oryzae.
    Pest management science, 2018, Volume: 74, Issue:12

    Topics: Anti-Bacterial Agents; Catalase; Glutathione; Glutathione Disulfide; Oxidative Stress; Reactive Oxygen Species; Sequence Deletion; Sesquiterpenes; Xanthomonas

2018
Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway.
    Respiratory research, 2018, 06-05, Volume: 19, Issue:1

    Topics: A549 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bleomycin; Humans; Male; Mice; Mice, Inbred ICR; NF-kappa B; Pulmonary Fibrosis; Sesquiterpenes; Signal Transduction; Snail Family Transcription Factors

2018
Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases.
    Molecules (Basel, Switzerland), 2018, Jun-19, Volume: 23, Issue:6

    Topics: HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Interleukin-6; Janus Kinases; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor

2018
Parthenolide in Danish biodynamic and organic milk: A new source of exposure to an allergenic sesquiterpene lactone.
    Contact dermatitis, 2018, Volume: 79, Issue:4

    Topics: Allergens; Animals; Asteraceae; Denmark; Dermatitis, Allergic Contact; Gas Chromatography-Mass Spectrometry; Humans; Milk; Organic Agriculture; Sesquiterpenes

2018
Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide.
    Clinical & experimental metastasis, 2018, Volume: 35, Issue:7

    Topics: Adenocarcinoma; Animals; Disease Progression; Drug Interactions; Ethanol; Female; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Metastasis; Prostatic Neoplasms; Sesquiterpenes

2018
Biodegradable, Drug-Loaded Nanovectors via Direct Hydration as a New Platform for Cancer Therapeutics.
    Small (Weinheim an der Bergstrasse, Germany), 2018, Volume: 14, Issue:32

    Topics: Antineoplastic Agents; Biocompatible Materials; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Nanoparticles; Polymers; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sesquiterpenes; Water

2018
Parthenolide Influences Herpes simplex virus 1 Replication in vitro.
    Intervirology, 2018, Volume: 61, Issue:1

    Topics: Animals; Antiviral Agents; Caspases; Cell Survival; Chlorocebus aethiops; Herpes Simplex; Herpesvirus 1, Human; Humans; NF-kappa B; Plant Components, Aerial; Sesquiterpenes; Tanacetum; Vero Cells; Viral Proteins; Virus Replication

2018
Inhibition of NF-κB Reduces Renal Inflammation and Expression of PEPCK in Type 2 Diabetic Mice.
    Inflammation, 2018, Volume: 41, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gluconeogenesis; Inflammation; Insulin Resistance; Kidney; Mice; NF-kappa B; Phosphoenolpyruvate Carboxykinase (GTP); Sesquiterpenes

2018
Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:10

    Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin D1; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Recurrence, Local; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction

2018
Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents.
    Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Esters; Heterografts; Humans; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Mice; Molecular Structure; Sesquiterpenes; Thiocarbamates

2018
Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 107

    Topics: A549 Cells; Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neovascularization, Pathologic; Nicotine; Real-Time Polymerase Chain Reaction; Sesquiterpenes; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A

2018
The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis.
    Artificial cells, nanomedicine, and biotechnology, 2018, Volume: 46, Issue:sup3

    Topics: A549 Cells; Animals; Apoptosis; Delayed-Action Preparations; Ginsenosides; Humans; Liposomes; Lung Neoplasms; Mice; Mice, Nude; Mitochondria; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays

2018
MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide.
    Anticancer research, 2018, Volume: 38, Issue:11

    Topics: 3' Untranslated Regions; A549 Cells; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cell Survival; Computational Biology; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Lung Neoplasms; MicroRNAs; Sesquiterpenes

2018
Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity.
    Nature communications, 2018, 11-07, Volume: 9, Issue:1

    Topics: Biosynthetic Pathways; Cyclization; Cytochrome P-450 Enzyme System; Hydroxylation; Molecular Docking Simulation; Nicotiana; Saccharomyces cerevisiae; Sesquiterpenes; Tanacetum

2018
Comparison of the inhibition potential of parthenolide and micheliolide on various UDP-glucuronosyltransferase isoforms.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:10

    Topics: Enzyme Inhibitors; Glucuronosyltransferase; Humans; Kinetics; Sesquiterpenes; Sesquiterpenes, Guaiane

2019
TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:3

    Topics: Analgesics; Animals; Calcium Channels; Cell Line; Crocus; Cyclohexenes; Ganglia, Spinal; HEK293 Cells; Humans; Isothiocyanates; Mice; Mice, Inbred C57BL; Neurons; Nociception; Sesquiterpenes; Terpenes; TRPA1 Cation Channel; TRPV Cation Channels

2019
Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents.
    European journal of medicinal chemistry, 2019, Mar-15, Volume: 166

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Chemistry Techniques, Synthetic; Humans; Sesquiterpenes; Structure-Activity Relationship; Triple Negative Breast Neoplasms

2019
Substrate promiscuity of enzymes from the sesquiterpene biosynthetic pathways from Artemisia annua and Tanacetum parthenium allows for novel combinatorial sesquiterpene production.
    Metabolic engineering, 2019, Volume: 54

    Topics: Artemisia annua; Metabolic Engineering; Oxidoreductases; Plant Proteins; Sesquiterpenes; Tanacetum parthenium

2019
Pharmacological Inhibition of NFκB Reduces Prostate Cancer Related Osteoclastogenesis In Vitro and Osteolysis Ex Vivo.
    Calcified tissue international, 2019, Volume: 105, Issue:2

    Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Survival; Coculture Techniques; DNA Fragmentation; Humans; Male; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; NF-kappa B p50 Subunit; Organ Culture Techniques; Osteoblasts; Osteoclasts; Osteogenesis; Prostatic Neoplasms; Rats; Sesquiterpenes; Signal Transduction; X-Ray Microtomography

2019
Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia.
    Bioorganic chemistry, 2019, Volume: 87

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Molecular Docking Simulation; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured; Vorinostat

2019
Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry.
    Journal of Asian natural products research, 2020, Volume: 22, Issue:5

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Sesquiterpenes; Thiazolidinediones

2020
Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2/Keap1 pathway.
    Pharmacological research, 2019, Volume: 145

    Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Diet, High-Fat; Heme Oxygenase-1; Kelch-Like ECH-Associated Protein 1; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Obesity; Phytochemicals; RAW 264.7 Cells; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Tanacetum parthenium

2019
Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.
    Cell chemical biology, 2019, 07-18, Volume: 26, Issue:7

    Topics: Biological Products; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lactones; Sesquiterpenes; Signal Transduction; Tanacetum parthenium

2019
Costunolide and parthenolide from Champi Sirindhorn (
    Natural product research, 2021, Volume: 35, Issue:6

    Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Humans; Inhibitory Concentration 50; K562 Cells; Magnolia; Plant Extracts; Sesquiterpenes; Thailand

2021
Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia.
    Molecules (Basel, Switzerland), 2019, Jun-03, Volume: 24, Issue:11

    Topics: Adolescent; Adult; Aged; Antigens, CD; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dynamic Light Scattering; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Nanoparticles; NF-kappa B; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Sesquiterpenes; Young Adult

2019
Screening for Compositae contact sensitization with sesquiterpene lactones and Compositae mix 2.5% pet.
    Contact dermatitis, 2019, Volume: 81, Issue:5

    Topics: Adolescent; Adult; Allergens; Asteraceae; Child; Child, Preschool; Dermatitis, Allergic Contact; Female; Humans; Lactones; Male; Middle Aged; Patch Tests; Plant Extracts; Sesquiterpenes; Young Adult

2019
A loop involving NRF2, miR-29b-1-5p and AKT, regulates cell fate of MDA-MB-231 triple-negative breast cancer cells.
    Journal of cellular physiology, 2020, Volume: 235, Issue:2

    Topics: Cell Line, Tumor; Cell Proliferation; Cyclin D2; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; NF-E2-Related Factor 2; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Triple Negative Breast Neoplasms; Tumor Suppressor Proteins

2020
Parthenolide ameliorates intracerebral hemorrhage-induced brain injury in rats.
    Phytotherapy research : PTR, 2020, Volume: 34, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Brain Injuries; Cerebral Hemorrhage; Disease Models, Animal; Mice; Oxidative Stress; Rats; Sesquiterpenes

2020
Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Nucleus; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neoplasms; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured

2019
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
    Behavioural brain research, 2020, 02-03, Volume: 379

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Apoptosis; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Inflammation; Levodopa; Male; Mice; Mice, Inbred BALB C; Nerve Degeneration; Parkinson Disease; Parkinsonian Disorders; Sesquiterpenes

2020
Synthesis and biological profiling of parthenolide ether analogs.
    Organic & biomolecular chemistry, 2019, 12-07, Volume: 17, Issue:45

    Topics: Adult; Carboxypeptidases; Enzyme Inhibitors; Ether; Humans; Microtubules; Molecular Structure; Neurons; Sesquiterpenes; Structure-Activity Relationship; Tanacetum parthenium

2019
The Anti-Serotonin Effect of Parthenolide Derivatives and Standardised Extract from the Leaves of
    Molecules (Basel, Switzerland), 2019, Nov-15, Volume: 24, Issue:22

    Topics: Animals; Asteraceae; Blood Platelets; Female; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Sesquiterpenes

2019
Parthenolide, an NF-κB inhibitor, alleviates peritoneal fibrosis by suppressing the TGF-β/Smad pathway.
    International immunopharmacology, 2020, Volume: 78

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Dialysis Solutions; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelial-Mesenchymal Transition; Female; Humans; Male; Mice; Peritoneal Dialysis; Peritoneal Fibrosis; Peritoneum; Phosphorylation; Sesquiterpenes; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1

2020
A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.
    Nanomedicine (London, England), 2020, Volume: 15, Issue:1

    Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Betulinic Acid; Biphenyl Compounds; Cell Proliferation; Cisplatin; Ginsenosides; Humans; Lignans; Liposomes; Lung Neoplasms; Mice; Neoplasm Invasiveness; Pentacyclic Triterpenes; Sesquiterpenes; Triterpenes; Xenograft Model Antitumor Assays

2020
Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium.
    Circulation, 2020, 03-17, Volume: 141, Issue:11

    Topics: Adult; Aged; Colchicine; Diastole; Elasticity; Female; Heart Failure; Humans; Male; Microtubules; Middle Aged; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Protein Processing, Post-Translational; Sesquiterpenes; Stress, Mechanical; Stroke Volume; Tyrosine; Ventricular Dysfunction, Left; Viscosity

2020
Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo.
    Journal of medicinal chemistry, 2020, 02-27, Volume: 63, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Prodrugs; Protein Kinase Inhibitors; Pyruvate Kinase; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays

2020
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth.
    The Journal of biological chemistry, 2020, 03-13, Volume: 295, Issue:11

    Topics: 4-Butyrolactone; Apoptosis; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Proteolysis; Sesquiterpenes; Ubiquitin-Specific Peptidase 7; Ubiquitination; Wnt Signaling Pathway

2020
Nanomagnetic liposome-encapsulated parthenolide and indocyanine green for targeting and chemo-photothermal antitumor therapy.
    Nanomedicine (London, England), 2020, Volume: 15, Issue:9

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Ferric Compounds; Indocyanine Green; Liposomes; Metal Nanoparticles; Photochemotherapy; Phototherapy; Sesquiterpenes

2020
All-stage precisional glioma targeted therapy enabled by a well-designed D-peptide.
    Theranostics, 2020, Volume: 10, Issue:9

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Carriers; Endoplasmic Reticulum Chaperone BiP; Glioma; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Micelles; Paclitaxel; Peptides; Polyethylene Glycols; Rats, Sprague-Dawley; Sesquiterpenes; Temozolomide

2020
Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK.
    Chemical biology & drug design, 2020, Volume: 96, Issue:2

    Topics: 4-Butyrolactone; Amines; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Female; Humans; Molecular Targeted Therapy; NF-kappa B; Ovarian Neoplasms; Piperazines; Piperidines; Prodrugs; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Sesquiterpenes; Signal Transduction; Structure-Activity Relationship

2020
Preparation and characterization of parthenolide nanocrystals for enhancing therapeutic effects of sorafenib against advanced hepatocellular carcinoma.
    International journal of pharmaceutics, 2020, Jun-15, Volume: 583

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Compounding; Drug Liberation; Drug Stability; Drug Synergism; Female; Hep G2 Cells; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Sesquiterpenes; Solubility; Sorafenib; Tumor Burden; Xenograft Model Antitumor Assays

2020
Nano magnetic liposomes-encapsulated parthenolide and glucose oxidase for ultra-efficient synergistic antitumor therapy.
    Nanotechnology, 2020, Aug-28, Volume: 31, Issue:35

    Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Compounding; Drug Synergism; Female; Glucose Oxidase; Glutathione; HeLa Cells; Humans; Liposomes; Magnetite Nanoparticles; Mice; Sesquiterpenes; Tumor Microenvironment; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2020
Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer.
    International journal of nanomedicine, 2020, Volume: 15

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Delivery Systems; Endocytosis; Female; Humans; Hydrodynamics; Indocyanine Green; Liposomes; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Photosensitizing Agents; Reactive Oxygen Species; Sesquiterpenes; Temperature; Tissue Distribution; Treatment Outcome; Triple Negative Breast Neoplasms; Tumor Burden

2020
Cytokine storm in COVID-19 and parthenolide: Preclinical evidence.
    Phytotherapy research : PTR, 2020, Volume: 34, Issue:10

    Topics: Anti-Inflammatory Agents; Betacoronavirus; Coronavirus; Coronavirus Infections; COVID-19; Cytokines; Humans; Inflammation; Pandemics; Phytotherapy; Plant Extracts; Pneumonia, Viral; SARS-CoV-2; Sesquiterpenes; Tanacetum parthenium

2020
Metabonomic study of the intervention effects of Parthenolide on anti-thyroid cancer activity.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Aug-01, Volume: 1150

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Metabolome; Metabolomics; Reactive Oxygen Species; Sesquiterpenes; Thyroid Neoplasms

2020
Compositae sensitization in Danish children and adolescents.
    Contact dermatitis, 2020, Volume: 83, Issue:4

    Topics: Adolescent; Allergens; Asteraceae; Child; Denmark; Dermatitis, Allergic Contact; Female; Humans; Male; Plant Extracts; Sesquiterpenes

2020
Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones.
    Bioorganic & medicinal chemistry, 2020, 07-01, Volume: 28, Issue:13

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carbamates; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Neoplasms, Experimental; NF-kappa B; Semicarbazones; Sesquiterpenes; Structure-Activity Relationship; Thiosemicarbazones

2020
Parthenolide ameliorates tweak-induced podocytes injury.
    Molecular biology reports, 2020, Volume: 47, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Chemokine CXCL16; Cholesterol; Mice; Podocytes; Sesquiterpenes; Tumor Necrosis Factor-alpha

2020
Deciphering morpho-physiological and phytochemical attributes of Tanacetum parthenium L. plants exposed to C60 fullerene and salicylic acid.
    Chemosphere, 2020, Volume: 259

    Topics: Chlorophyll A; Fullerenes; Oils, Volatile; Phytochemicals; Plant Leaves; Salicylic Acid; Sesquiterpenes; Tanacetum parthenium

2020
Anticancer and apoptotic activities of parthenolide in combination with epirubicin in mda-mb-468 breast cancer cells.
    Molecular biology reports, 2020, Volume: 47, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epirubicin; Female; Humans; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Topoisomerase II Inhibitors

2020
Parthenolide inhibits human lung cancer cell growth by modulating the IGF‑1R/PI3K/Akt signaling pathway.
    Oncology reports, 2020, Volume: 44, Issue:3

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Forkhead Box Protein O3; Humans; Insulin-Like Growth Factor I; Lung Neoplasms; Male; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Sesquiterpenes; Signal Transduction; Xenograft Model Antitumor Assays

2020
Cytotoxicity of the Sesquiterpene Lactones, Ivalin and Parthenolide in Murine Muscle Cell Lines and Their Effect on Desmin, a Cytoskeletal Intermediate Filament.
    Toxins, 2020, 07-18, Volume: 12, Issue:7

    Topics: Animals; Cell Line; Cell Survival; Cytoskeleton; Desmin; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Lactones; Mice; Myoblasts, Skeletal; Myocytes, Cardiac; Rats; Sesquiterpenes

2020
Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome.
    Bioorganic & medicinal chemistry letters, 2020, 09-01, Volume: 30, Issue:17

    Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Drug Design; Humans; Inflammasomes; Interleukin-1beta; Lipopolysaccharides; Mice; Neuroglia; NLR Family, Pyrin Domain-Containing 3 Protein; Sesquiterpenes; Signal Transduction

2020
Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling.
    International journal of molecular sciences, 2020, Jul-30, Volume: 21, Issue:15

    Topics: Asteraceae; Cell Differentiation; Gene Expression Regulation, Developmental; Humans; Hydrolases; Inflammation; JNK Mitogen-Activated Protein Kinases; Lactones; MAP Kinase Signaling System; NF-kappa B; Osteoblasts; Osteogenesis; Periosteum; Phenotype; Phosphorylation; Sesquiterpenes; Tumor Necrosis Factor-alpha

2020
α-Methylene-β-Lactone Scaffold for Developing Chemical Probes at the Two Ends of the Selectivity Spectrum.
    Chembiochem : a European journal of chemical biology, 2021, 02-02, Volume: 22, Issue:3

    Topics: Humans; Lactones; Molecular Probes; Molecular Structure; Orlistat; Proteomics; Sesquiterpenes; Tandem Mass Spectrometry

2021
Osteopontin siRNA does not confer resistance to toxic effects of parthenolide in Jurkat cells.
    Experimental oncology, 2020, Volume: 42, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression; Humans; Jurkat Cells; Osteopontin; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sesquiterpenes

2020
Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2020, Volume: 40, Issue:6

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cyclin D1; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Stomach Neoplasms

2020
Parthenolide inhibits the tumor characteristics of renal cell carcinoma.
    International journal of oncology, 2021, Volume: 58, Issue:1

    Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Neoplastic Stem Cells; Sesquiterpenes; Snail Family Transcription Factors

2021
Inhibition of NF-κB by ACT001 reduces fibroblast activity in idiopathic pulmonary fibrosis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 138

    Topics: Adult; Aged; Cell Survival; Dose-Response Relationship, Drug; Female; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Male; Middle Aged; NF-kappa B; Sesquiterpenes

2021
The role of oxidative stress in the cooperation of parthenolide and etoposide in HL-60 cells.
    Folia medica Cracoviensia, 2020, Volume: 60, Issue:4

    Topics: Apoptosis; Etoposide; HL-60 Cells; Humans; Oxidative Stress; Sesquiterpenes

2020
Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway.
    Molecular medicine reports, 2021, Volume: 24, Issue:1

    Topics: Animals; Disease Models, Animal; Fibrosis; Hippo Signaling Pathway; Inflammation; Lipid Metabolism; Male; Metabolic Diseases; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protective Agents; Protein Serine-Threonine Kinases; Sesquiterpenes; Signal Transduction

2021
Design, synthesis and in vivo anticancer activity of novel parthenolide and micheliolide derivatives as NF-κB and STAT3 inhibitors.
    Bioorganic chemistry, 2021, Volume: 111

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neoplasms, Experimental; NF-kappa B; Sesquiterpenes; Sesquiterpenes, Guaiane; STAT3 Transcription Factor; Structure-Activity Relationship; Tumor Cells, Cultured

2021
USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide.
    Biochemical and biophysical research communications, 2021, 07-12, Volume: 562

    Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Neoplastic Stem Cells; Prognosis; Protein Binding; Sesquiterpenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases; Up-Regulation

2021
Parthenolide, bioactive compound of Chrysanthemum parthenium L., ameliorates fibrogenesis and inflammation in hepatic fibrosis via regulating the crosstalk of TLR4 and STAT3 signaling pathway.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:10

    Topics: Inflammation; Liver Cirrhosis; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Tanacetum parthenium; Toll-Like Receptor 4

2021
Cyclosporine A and Tacrolimus Induce Functional Impairment and Inflammatory Reactions in Endothelial Progenitor Cells.
    International journal of molecular sciences, 2021, Sep-08, Volume: 22, Issue:18

    Topics: Cardiovascular Diseases; Cell Movement; Cell Proliferation; Chemotaxis; Cyclosporine; Cytokines; Endothelial Cells; Endothelial Progenitor Cells; Humans; Immunosuppressive Agents; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Neovascularization, Pathologic; NF-kappa B; NF-kappa B p50 Subunit; Sesquiterpenes; Signal Transduction; Stem Cells; Tacrolimus; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2021
The effect of parthenolide on methamphetamine-induced blood-brain barrier and astrocyte alterations.
    European journal of clinical investigation, 2022, Volume: 52, Issue:4

    Topics: Animals; Astrocytes; Blood-Brain Barrier; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Sesquiterpenes

2022
Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice.
    Canadian journal of physiology and pharmacology, 2022, Volume: 100, Issue:3

    Topics: Animals; Blood Glucose; Diet, High-Fat; Dose-Response Relationship, Drug; Insulin Resistance; Interleukin-1beta; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Obesity; Pioglitazone; Sesquiterpenes; Tumor Necrosis Factor-alpha

2022
The effects of several abiotic elicitors on the expression of genes of key enzymes involved in the parthenolide biosynthetic pathway and its content in feverfew plant (
    Natural product research, 2022, Volume: 36, Issue:23

    Topics: Biosynthetic Pathways; Plant Extracts; Salicylic Acid; Sesquiterpenes; Tanacetum parthenium

2022
Parthenolide leads to proteomic differences in thyroid cancer cells and promotes apoptosis.
    BMC complementary medicine and therapies, 2022, Apr-02, Volume: 22, Issue:1

    Topics: Apoptosis; Humans; Proteomics; Sesquiterpenes; Thyroid Neoplasms

2022
Mining and characterization of oxidative stress-related binding proteins of parthenolide in Xanthomonas oryzae pv. oryzae.
    Pest management science, 2022, Volume: 78, Issue:8

    Topics: Anti-Bacterial Agents; Carrier Proteins; Chromatography, Liquid; Oryza; Oxidative Stress; Plant Diseases; Reactive Oxygen Species; Sesquiterpenes; Tandem Mass Spectrometry; Xanthomonas

2022
Parthenolide Suppresses T Helper 17 and Alleviates Experimental Autoimmune Encephalomyelitis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; NF-kappa B; Nuclear Receptor Subfamily 1, Group F, Member 3; Sesquiterpenes; Th17 Cells

2022
Parthenolide reverses the epithelial to mesenchymal transition process in breast cancer by targeting TGFbeta1: In vitro and in silico studies.
    Life sciences, 2022, Jul-15, Volume: 301

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Female; Humans; Molecular Docking Simulation; Sesquiterpenes; Transforming Growth Factor beta1

2022
Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory.
    ACS synthetic biology, 2022, 07-15, Volume: 11, Issue:7

    Topics: Furans; Lactones; NADP; Plants; Saccharomyces cerevisiae; Sesquiterpenes

2022
Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3/NF-κB and inflammasome activation.
    International immunopharmacology, 2022, Volume: 108

    Topics: Animals; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Female; Inflammasomes; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroinflammatory Diseases; Neuroprotective Agents; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Sesquiterpenes

2022
Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV‑2 papain-like protease.
    Acta biochimica et biophysica Sinica, 2022, Aug-25, Volume: 54, Issue:8

    Topics: Antiviral Agents; Coronavirus Papain-Like Proteases; COVID-19 Drug Treatment; Humans; Interferons; Lactones; Molecular Docking Simulation; Papain; Peptide Hydrolases; SARS-CoV-2; Sesquiterpenes; Sesquiterpenes, Germacrane; Ubiquitin

2022
A dual-responsive "Yin-Yang" photothermal delivery system to accelerate Parthenolide anti-tumor efficacy.
    Biomaterials advances, 2022, Volume: 138

    Topics: Antineoplastic Agents; Gold; Humans; Hyperthermia, Induced; Liposomes; Neoplasms; Phototherapy; Sesquiterpenes; Tumor Microenvironment

2022
Parthenolide modulates cerebral ischemia-induced microglial polarization and alleviates neuroinflammatory injury via the RhoA/ROCK pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 105

    Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cerebral Infarction; Humans; Microglia; Rats; rhoA GTP-Binding Protein; Sesquiterpenes; Stroke

2022
First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor.
    Molecules (Basel, Switzerland), 2022, Sep-23, Volume: 27, Issue:19

    Topics: Anticholesteremic Agents; Cholesterol; Ezetimibe; Filipin; Humans; Hypercholesterolemia; Hyperlipidemias; Membrane Transport Proteins; Molecular Docking Simulation; Sesquiterpenes

2022
Individual lipid transfer proteins from Tanacetum parthenium show different specificity for extracellular accumulation of sesquiterpenes.
    Plant molecular biology, 2023, Volume: 111, Issue:1-2

    Topics: Lipids; Sesquiterpenes; Tanacetum parthenium

2023
Parthenolide targets NF-κB (P50) to inhibit HIF-1α-mediated metabolic reprogramming of HCC.
    Aging, 2022, 10-18, Volume: 14, Issue:20

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Hypoxia-Inducible Factor 1, alpha Subunit; Lactates; Liver Neoplasms; Mice; NF-kappa B; Sesquiterpenes

2022
Occupational protein contact dermatitis caused by lettuce and overlap allergic contact dermatitis by parthenolide: A diagnostic approach.
    The Australasian journal of dermatology, 2023, Volume: 64, Issue:2

    Topics: Dermatitis, Allergic Contact; Dermatitis, Occupational; Hand Dermatoses; Humans; Lactuca; Patch Tests; Sesquiterpenes

2023
Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis.
    Molecules (Basel, Switzerland), 2023, Mar-17, Volume: 28, Issue:6

    Topics: Animals; Antioxidants; Gentamicins; Kidney; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Phytosomes; Rats; Sesquiterpenes; Sirtuin 1

2023
Inhibitory effect of parthenolide on peripheral nerve degeneration.
    Anatomical science international, 2023, Volume: 98, Issue:4

    Topics: Axons; Humans; Nerve Degeneration; Nerve Regeneration; Peripheral Nervous System Diseases; Schwann Cells; Sciatic Nerve; Sesquiterpenes

2023
Parthenolide targets NLRP3 to treat inflammasome-related diseases.
    International immunopharmacology, 2023, Volume: 119

    Topics: Animals; Dextran Sulfate; Humans; Inflammasomes; Inflammation; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Sesquiterpenes

2023
Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies.
    International journal of molecular sciences, 2023, May-23, Volume: 24, Issue:11

    Topics: Apoptosis; Cell Line, Tumor; Humans; I-kappa B Proteins; Lymphoma; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes

2023
Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:12

    Topics: Analgesics; Animals; Neuralgia; Paclitaxel; Rats; Sesquiterpenes

2023
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide.
    Cellular & molecular biology letters, 2023, Aug-24, Volume: 28, Issue:1

    Topics: Chromatography, Liquid; Desmocollins; Humans; MCF-7 Cells; Neoplasms; Proteome; Sesquiterpenes; Tandem Mass Spectrometry

2023
Parthenolide repressed endometriosis induced surgically in rats: Role of PTEN/PI3Kinase/AKT/GSK-3β/β-catenin signaling in inhibition of epithelial mesenchymal transition.
    Life sciences, 2023, Oct-15, Volume: 331

    Topics: Animals; beta Catenin; Cadherins; Cell Movement; Endometriosis; Epithelial-Mesenchymal Transition; Female; Glycogen Synthase Kinase 3 beta; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Sesquiterpenes; Signal Transduction; Vimentin

2023
Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 167

    Topics: Blood-Brain Barrier; Endothelial Cells; Lactones; Sesquiterpenes

2023